Guy A Rutter

Guy A Rutter

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Guy A Rutter

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Effects on pancreatic Beta and other Islet cells of the glucose-dependent insulinotropic polypeptide.

Peptides 2019 Nov 18:170201. Epub 2019 Nov 18.

Section of Cell Biology and Functional Genomics, Division of Diabetes, Endocrinology and Metabolism, Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK.

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http://dx.doi.org/10.1016/j.peptides.2019.170201DOI Listing
November 2019

Metabolic and Functional Heterogeneity in Pancreatic β Cells.

J Mol Biol 2019 Aug 13. Epub 2019 Aug 13.

Section of Cell Biology and Functional Genomics, Department of Medicine, Imperial College London, Hammersmith Hospital, Du Cane Road, London, W12 0NN, United Kingdom; Lee Kong Chian School of Medicine, Nan Yang Technological University, Singapore.

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http://dx.doi.org/10.1016/j.jmb.2019.08.005DOI Listing
August 2019

Zn-transporters ZIP7 and ZnT7 play important role in progression of cardiac dysfunction via affecting sarco(endo)plasmic reticulum-mitochondria coupling in hyperglycemic cardiomyocytes.

Mitochondrion 2019 01 4;44:41-52. Epub 2018 Jan 4.

Departments of Biophysics, Ankara University Faculty of Medicine, 06100 Ankara, Turkey. Electronic address:

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http://dx.doi.org/10.1016/j.mito.2017.12.011DOI Listing
January 2019

Manipulation and Measurement of AMPK Activity in Pancreatic Islets.

Methods Mol Biol 2018 ;1732:413-431

Section of Cell Biology and Functional Genomics, Division of Diabetes, Endocrinology and Metabolism, Imperial College London, London, UK.

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http://dx.doi.org/10.1007/978-1-4939-7598-3_26DOI Listing
January 2019

The α-cell in diabetes mellitus.

Nat Rev Endocrinol 2018 12;14(12):694-704

Section of Cell Biology and Functional Genomics, Division of Diabetes, Endocrinology and Metabolism, Department of Medicine, Imperial College London, Hammersmith Hospital Campus, London, UK.

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http://dx.doi.org/10.1038/s41574-018-0097-yDOI Listing
December 2018

Hypothalamic arcuate nucleus glucokinase regulates insulin secretion and glucose homeostasis.

Diabetes Obes Metab 2018 09 12;20(9):2246-2254. Epub 2018 Jun 12.

Section of Endocrinology and Investigative Medicine, Division of Diabetes, Endocrinology and Metabolism, Imperial College London, London, UK.

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http://dx.doi.org/10.1111/dom.13359DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6099255PMC
September 2018

Transcription factor-7-like 2 () gene acts downstream of the / kinase to control mTOR signaling, β cell growth, and insulin secretion.

J Biol Chem 2018 09 2;293(36):14178-14189. Epub 2018 Jul 2.

From the Section of Cell Biology and Functional Genomics and Pancreatic Islet and Diabetes Consortium, Division of Diabetes, Endocrinology and Metabolism, Imperial Centre for Translational and Experimental Medicine, Department of Medicine, Imperial College London, London W12 0NN, United Kingdom

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http://dx.doi.org/10.1074/jbc.RA118.003613DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6130960PMC
September 2018

The Impact of Pancreatic Beta Cell Heterogeneity on Type 1 Diabetes Pathogenesis.

Curr Diab Rep 2018 09 24;18(11):112. Epub 2018 Sep 24.

Section of Cell Biology and Functional Genomics, Department of Medicine, Imperial College London, London, W12 0NN, UK.

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http://dx.doi.org/10.1007/s11892-018-1085-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6153573PMC
September 2018

MiR-184 expression is regulated by AMPK in pancreatic islets.

FASEB J 2018 05 8;32(5):2587-2600. Epub 2018 Jan 8.

Section of Cell Biology and Functional Genomics Division of Diabetes, Endocrinology, and Metabolism, Department of Medicine, Imperial College London, London, United Kingdom.

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http://dx.doi.org/10.1096/fj.201701100RDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6207280PMC
May 2018

Author Correction: Beta cell connectivity in pancreatic islets: a type 2 diabetes target?

Cell Mol Life Sci 2018 04;75(7):1303-1305

Section of Cell Biology, Department of Medicine, Imperial College London, Imperial Centre for Translational and Experimental Medicine, Hammersmith Hospital, Du Cane Road, London, W12 0NN, UK.

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http://dx.doi.org/10.1007/s00018-018-2767-2DOI Listing
April 2018

A Targeted RNAi Screen Identifies Endocytic Trafficking Factors That Control GLP-1 Receptor Signaling in Pancreatic β-Cells.

Diabetes 2018 Mar 28;67(3):385-399. Epub 2017 Dec 28.

Section of Cell Biology and Functional Genomics and Pancreatic Islet Biology and Diabetes Consortium, Imperial College London, London, U.K.

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http://dx.doi.org/10.2337/db17-0639DOI Listing
March 2018

Control of insulin secretion by GLP-1.

Peptides 2018 02;100:75-84

Section of Cell Biology and Functional Genomics & Imperial Consortium for Islet Biology and Diabetes, Division of Diabetes, Endocrinology and Metabolism, Department of Medicine, Imperial College London, Hammersmith Campus, Du Cane Road, London, W12 0NN, UK. Electronic address:

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http://dx.doi.org/10.1016/j.peptides.2017.12.013DOI Listing
February 2018

Sensors for measuring subcellular zinc pools.

Metallomics 2018 02;10(2):229-239

Imperial College London, Hammersmith Hospital Campus, Du Cane Road, London, W12 0NN, UK.

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http://dx.doi.org/10.1039/c7mt00336fDOI Listing
February 2018

Local and regional control of calcium dynamics in the pancreatic islet.

Diabetes Obes Metab 2017 09;19 Suppl 1:30-41

Section of Cell Biology and Functional Genomics, Division of Diabetes, Endocrinology and Metabolism, Department of Medicine, and the Imperial Pancreatic Islet Biology and Diabetes Consortium, Hammersmith Hospital, Imperial College London, London, UK.

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http://dx.doi.org/10.1111/dom.12990DOI Listing
September 2017

Hyperglycemia-Induced Changes in ZIP7 and ZnT7 Expression Cause Zn Release From the Sarco(endo)plasmic Reticulum and Mediate ER Stress in the Heart.

Diabetes 2017 05 23;66(5):1346-1358. Epub 2017 Feb 23.

Department of Biophysics, Faculty of Medicine, Ankara University, Ankara, Turkey

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http://dx.doi.org/10.2337/db16-1099DOI Listing
May 2017

The transcription factor is required for pancreatic β cell identity, glucose-regulated ATP synthesis, and Ca dynamics in adult mice.

J Biol Chem 2017 05 4;292(21):8892-8906. Epub 2017 Apr 4.

From the Section of Cell Biology and Functional Genomics, Division of Diabetes, Endocrinology, and Metabolism, Imperial College London, Du Cane Road, London W12 0NN, United Kingdom,

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http://dx.doi.org/10.1074/jbc.M117.784629DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5448123PMC
May 2017

The Role of Oxidative Stress and Hypoxia in Pancreatic Beta-Cell Dysfunction in Diabetes Mellitus.

Antioxid Redox Signal 2017 04 30;26(10):501-518. Epub 2016 Jun 30.

2 Section of Cell Biology and Functional Genomics, Department of Medicine, Imperial College London , London, United Kingdom .

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http://dx.doi.org/10.1089/ars.2016.6755DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5372767PMC
April 2017

SLC30A9 mutation affecting intracellular zinc homeostasis causes a novel cerebro-renal syndrome.

Brain 2017 Apr;140(4):928-939

The Morris Kahn Laboratory of Human Genetics, National Institute for Biotechnology in the Negev and Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva 84105, Israel.

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http://dx.doi.org/10.1093/brain/awx013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5837213PMC
April 2017

Analysis of Purified Pancreatic Islet Beta and Alpha Cell Transcriptomes Reveals 11β-Hydroxysteroid Dehydrogenase (Hsd11b1) as a Novel Disallowed Gene.

Front Genet 2017 10;8:41. Epub 2017 Apr 10.

Section of Cell Biology and Functional Genomics, Department of Medicine, Imperial College LondonLondon, UK.

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http://dx.doi.org/10.3389/fgene.2017.00041DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5385341PMC
April 2017

Diabetes: Controlling the identity of the adult pancreatic β cell.

Authors:
Guy A Rutter

Nat Rev Endocrinol 2017 03 20;13(3):129-130. Epub 2017 Jan 20.

Section of Cell Biology and Functional Genomics, Division of Diabetes, Endocrinology and Metabolism, Imperial College London, Du Cane Road, London, W12 0NN, UK.

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http://dx.doi.org/10.1038/nrendo.2017.1DOI Listing
March 2017

GABA signaling: A route to new pancreatic β cells.

Authors:
Guy A Rutter

Cell Res 2017 03 10;27(3):309-310. Epub 2017 Feb 10.

Cell Biology and Functional Genomics, Division of Diabetes, Endocrinology and Metabolism, Imperial College London, Du Cane Road, London, W12 0NN, UK.

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http://dx.doi.org/10.1038/cr.2017.20DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5339837PMC
March 2017

Remote control of glucose homeostasis in vivo using photopharmacology.

Sci Rep 2017 03 22;7(1):291. Epub 2017 Mar 22.

Institute of Metabolism and Systems Research (IMSR) and Centre of Membrane Proteins and Receptors (COMPARE), University of Birmingham, Edgbaston, B15 2TT, UK.

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http://dx.doi.org/10.1038/s41598-017-00397-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5428208PMC
March 2017

MiRNAs in β-Cell Development, Identity, and Disease.

Front Genet 2016 11;7:226. Epub 2017 Jan 11.

Cellular Identity and Metabolism Group, MRC London Institute of Medical SciencesLondon, UK; Institute of Clinical Sciences, Faculty of Medicine, Imperial College LondonLondon, UK.

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http://dx.doi.org/10.3389/fgene.2016.00226DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5225124PMC
January 2017

Zinc and diabetes.

Arch Biochem Biophys 2016 Dec 1;611:79-85. Epub 2016 Jun 1.

Section of Cell Biology and Functional Genomics, Department of Medicine, Imperial College London, London, W120NN, UK. Electronic address:

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http://dx.doi.org/10.1016/j.abb.2016.05.022DOI Listing
December 2016

Lipid-tuned Zinc Transport Activity of Human ZnT8 Protein Correlates with Risk for Type-2 Diabetes.

J Biol Chem 2016 12 8;291(53):26950-26957. Epub 2016 Nov 8.

From the Department of Physiology, The Johns Hopkins School of Medicine, Baltimore, Maryland 21205 and

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http://www.jbc.org/lookup/doi/10.1074/jbc.M116.764605
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http://dx.doi.org/10.1074/jbc.M116.764605DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5207130PMC
December 2016

Changes in microRNA expression during differentiation of embryonic and induced pluripotent stem cells to definitive endoderm.

Gene Expr Patterns 2015 Sep-Nov;19(1-2):70-82. Epub 2015 Aug 13.

Endocrinology Section, Biotherapeutics Department, National Institute of Biological Standards and Control, Blanche Lane, South Mimms, Hertfordshire, EN6 3QG, UK. Electronic address:

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http://dx.doi.org/10.1016/j.gep.2015.08.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6101203PMC
September 2016

Cell type-specific deletion in mice reveals roles for PAS kinase in insulin and glucagon production.

Diabetologia 2016 09 24;59(9):1938-47. Epub 2016 Jun 24.

Section of Cell Biology and Functional Genomics, Division of Diabetes, Endocrinology and Metabolism, Department of Medicine, Imperial College London, Imperial Centre for Translational and Experimental Medicine, Hammersmith Hospital, du Cane Road, London, W12 0NN, UK.

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http://dx.doi.org/10.1007/s00125-016-4025-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4969360PMC
September 2016

Beta Cell Hubs Dictate Pancreatic Islet Responses to Glucose.

Cell Metab 2016 09 21;24(3):389-401. Epub 2016 Jul 21.

Section of Cell Biology and Functional Genomics, Division of Diabetes, Endocrinology and Metabolism, Department of Medicine, Imperial College London, London W12 0NN, UK; Institute of Metabolism and Systems Research (IMSR) and Centre of Membrane Proteins and Receptors (COMPARE), University of Birmingham, Birmingham B15 2TT, UK; Centre for Endocrinology, Diabetes and Metabolism, Birmingham Health Partners, Birmingham B15 2TH, UK. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2016.06.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5031557PMC
September 2016

Photoswitchable diacylglycerols enable optical control of protein kinase C.

Nat Chem Biol 2016 09 25;12(9):755-62. Epub 2016 Jul 25.

Department of Chemistry and Center for Integrated Protein Science, Ludwig Maximilians University Munich, Munich, Germany.

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http://dx.doi.org/10.1038/nchembio.2141DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6101201PMC
September 2016

Modeling Type 2 Diabetes GWAS Candidate Gene Function in hESCs.

Authors:
Guy A Rutter

Cell Stem Cell 2016 09;19(3):281-2

Section of Cell Biology and Functional Genomics, Department of Medicine, Imperial Centre for Translational and Experimental Medicine, Hammersmith Hospital Campus, Imperial College London, Du Cane Road, London, W12 0NN, UK. Electronic address:

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http://dx.doi.org/10.1016/j.stem.2016.08.010DOI Listing
September 2016

Proglucagon-Derived Peptides Do Not Significantly Affect Acute Exocrine Pancreas in Rats.

Pancreas 2016 08;45(7):967-73

From the Sections of *Investigative Medicine and †Cell Biology and Functional Genomics, Division of Diabetes, Endocrinology and Metabolism, Department of Medicine, Imperial College London, Hammersmith Hospital, London, United Kingdom.

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http://dx.doi.org/10.1097/MPA.0000000000000585DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4820085PMC
August 2016

Over-expression of Slc30a8/ZnT8 selectively in the mouse α cell impairs glucagon release and responses to hypoglycemia.

Nutr Metab (Lond) 2016 7;13:46. Epub 2016 Jul 7.

Section of Cell Biology and Functional Genomics, Division of Diabetes Endocrinology and Metabolism, Department of Medicine, Imperial College London, Imperial Centre for Translational and Experimental Medicine, Hammersmith Hospital, du Cane Road, London, W12 0NN UK.

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http://dx.doi.org/10.1186/s12986-016-0104-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4936320PMC
July 2016

Disallowance of Acot7 in β-Cells Is Required for Normal Glucose Tolerance and Insulin Secretion.

Diabetes 2016 05 9;65(5):1268-82. Epub 2016 Feb 9.

Section of Cell Biology and Functional Genomics, Division of Diabetes, Endocrinology and Metabolism, Imperial Centre for Translational and Experimental Medicine, Imperial College London, London, U.K.

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http://dx.doi.org/10.2337/db15-1240DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6101210PMC
May 2016

Calcium-insensitive splice variants of mammalian E1 subunit of 2-oxoglutarate dehydrogenase complex with tissue-specific patterns of expression.

Biochem J 2016 05 2;473(9):1165-78. Epub 2016 Mar 2.

Section of Cell Biology and Functional Genomics, Department of Medicine, ICTEM Building, Hammersmith Campus, Imperial College, du Cane Road, London W12 ONN, U.K.

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http://dx.doi.org/10.1042/BCJ20160135DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6101200PMC
May 2016

Allosteric Optical Control of a Class B G-Protein-Coupled Receptor.

Angew Chem Int Ed Engl 2016 05 5;55(19):5865-8. Epub 2016 Apr 5.

Imperial College London, Section of Cell Biology and Functional Genomics, Division of Diabetes, Endocrinology and Metabolism, Department of Medicine, Hammersmith Hospital, Du Cane Road, London, W12 0NN, UK.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5031193PMC
http://dx.doi.org/10.1002/anie.201600957DOI Listing
May 2016

Chronic Activation of γ2 AMPK Induces Obesity and Reduces β Cell Function.

Cell Metab 2016 May 28;23(5):821-36. Epub 2016 Apr 28.

Experimental Therapeutics, Radcliffe Department of Medicine, University of Oxford, Oxford, OX3 9DU, UK; Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, OX3 9DU, UK; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK; Experimental Therapeutics, Clinical Science Group, New Medicines, UCB Pharma S.A., Slough, Berkshire SL1 3WE, UK. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2016.04.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4873618PMC
May 2016

Sorcin Links Pancreatic β-Cell Lipotoxicity to ER Ca2+ Stores.

Diabetes 2016 04 28;65(4):1009-21. Epub 2016 Jan 28.

Section of Cell Biology and Functional Genomics, Division of Diabetes, Endocrinology & Metabolism, Department of Medicine, Imperial College London, London, U.K.

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http://dx.doi.org/10.2337/db15-1334DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4806657PMC
April 2016

Intracellular zinc in insulin secretion and action: a determinant of diabetes risk?

Proc Nutr Soc 2016 Feb 14;75(1):61-72. Epub 2015 Sep 14.

Section of Cell Biology and Functional Genomics,Division of Diabetes, Endocrinology and Metabolism,Imperial Centre for Translational and Experimental Medicine,Imperial College London,Du Cane Road,London W12 0NN,UK.

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http://dx.doi.org/10.1017/S0029665115003237DOI Listing
February 2016

Role of microRNAs in the age-associated decline of pancreatic beta cell function in rat islets.

Diabetologia 2016 Jan;59(1):161-169

Department of Fundamental Neurosciences, University of Lausanne, Rue du Bugnon 9, CH-1005, Lausanne, Switzerland.

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http://dx.doi.org/10.1007/s00125-015-3783-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4670458PMC
January 2016

Molecular Genetic Regulation of Slc30a8/ZnT8 Reveals a Positive Association With Glucose Tolerance.

Mol Endocrinol 2016 Jan 19;30(1):77-91. Epub 2015 Nov 19.

Section of Cell Biology and Functional Genomics (R.K.M., M.H., P.L.C., M.C.C., G.M., E.A.B., D.J.H., G.A.R.), Division of Diabetes, Endocrinology and Metabolism, Imperial Centre for Translational and Experimental Medicine, Imperial College London, London W12 0NN, United Kingdom; Electron Microscopy Unit (R.C., L.M.C.), Francis Crick Institute, Lincoln's Inn Fields, London WC2A 3LY, United Kingdom; and Department of Cell Biology and Biochemistry (W.-H.L.), The University of Texas Southwestern Medical Center, Dallas, Texas 75390.

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https://academic.oup.com/mend/article-lookup/doi/10.1210/me.
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http://dx.doi.org/10.1210/me.2015-1227DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4995240PMC
January 2016

The two pore channel TPC2 is dispensable in pancreatic β-cells for normal Ca²⁺ dynamics and insulin secretion.

Cell Calcium 2016 Jan 23;59(1):32-40. Epub 2015 Dec 23.

Section of Cell Biology and Functional Genomics, Imperial College London, Du Cane Road, W12 0NN London, UK. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S01434160150017
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http://dx.doi.org/10.1016/j.ceca.2015.12.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4751975PMC
January 2016

Optical Control of Insulin Secretion Using an Incretin Switch.

Angew Chem Int Ed Engl 2015 Dec 2;54(51):15565-9. Epub 2015 Nov 2.

LMU Munich, Department of Chemistry and Centre for Integrated Protein Science (CIPSM), Butenandtstrasse 5-13, 81377 Munich (Germany).

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http://dx.doi.org/10.1002/anie.201506384DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4736448PMC
December 2015

eZinCh-2: A Versatile, Genetically Encoded FRET Sensor for Cytosolic and Intraorganelle Zn(2+) Imaging.

ACS Chem Biol 2015 Sep 20;10(9):2126-34. Epub 2015 Jul 20.

Laboratory of Chemical Biology and Institute of Complex Molecular Systems (ICMS), Department of Biomedical Engineering, Eindhoven University of Technology , Eindhoven, The Netherlands.

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http://dx.doi.org/10.1021/acschembio.5b00211DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4577962PMC
September 2015

Limited impact on glucose homeostasis of leptin receptor deletion from insulin- or proglucagon-expressing cells.

Mol Metab 2015 Sep 25;4(9):619-30. Epub 2015 Jun 25.

Section of Cell Biology and Functional Genomics, Division of Diabetes, Endocrinology and Metabolism, Department of Medicine, Imperial College London, du Cane Road, London W12 0NN, UK.

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http://dx.doi.org/10.1016/j.molmet.2015.06.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4563029PMC
September 2015

Loss of Liver Kinase B1 (LKB1) in Beta Cells Enhances Glucose-stimulated Insulin Secretion Despite Profound Mitochondrial Defects.

J Biol Chem 2015 Aug 2;290(34):20934-46. Epub 2015 Jul 2.

From the Department of Developmental Biology and Cancer Research, The Institute for Medical Research Israel-Canada, The Hebrew University-Hadassah Medical School, Jerusalem 91120, Israel,

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http://dx.doi.org/10.1074/jbc.M115.639237DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4543653PMC
August 2015

The Zinc Transporter Slc30a8/ZnT8 Is Required in a Subpopulation of Pancreatic α-Cells for Hypoglycemia-induced Glucagon Secretion.

J Biol Chem 2015 Aug 15;290(35):21432-42. Epub 2015 Jul 15.

From the Section of Cell Biology and Functional Genomics, Division of Diabetes Endocrinology and Metabolism, Department of Medicine, Imperial College London, London W12 0NN, United Kingdom,

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http://dx.doi.org/10.1074/jbc.M115.645291DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4571871PMC
August 2015

DICER Inactivation Identifies Pancreatic β-Cell "Disallowed" Genes Targeted by MicroRNAs.

Mol Endocrinol 2015 Jul 3;29(7):1067-79. Epub 2015 Jun 3.

Section of Cell Biology and Functional Genomics, Division of Diabetes, Endocrinology and Metabolism, Department of Medicine, Imperial College London, London W12 0NN, United Kingdom.

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http://dx.doi.org/10.1210/me.2015-1059DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4484783PMC
July 2015

Use of genetically encoded sensors to monitor cytosolic ATP/ADP ratio in living cells.

Methods Enzymol 2014 ;542:289-311

Section of Cell Biology, Department of Medicine, Imperial College London, London, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/B978-0-12-416618-9.00015-7DOI Listing
May 2015

Metformin activates a duodenal Ampk-dependent pathway to lower hepatic glucose production in rats.

Nat Med 2015 May 6;21(5):506-11. Epub 2015 Apr 6.

1] Toronto General Research Institute and Department of Medicine, University Health Network, Toronto, Ontario, Canada. [2] Department of Physiology, University of Toronto, Toronto, Ontario, Canada. [3] Department of Medicine, University of Toronto, Toronto, Ontario, Canada. [4] Banting and Best Diabetes Centre, University of Toronto, Toronto, Ontario, Canada.

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http://www.nature.com/doifinder/10.1038/nm.3787
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http://dx.doi.org/10.1038/nm.3787DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6104807PMC
May 2015

The role of microRNAs in the pancreatic differentiation of pluripotent stem cells.

Microrna 2014 ;3(1):54-63

Endocrinology Section, Biotherapeutics Department, National Institute of Biological Standards and Control, Blanche Lane, South Mimms, Hertfordshire, EN6 3QG, UK.

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http://dx.doi.org/10.2174/2211536603666140522003220DOI Listing
March 2015

Pancreatic β-cell identity, glucose sensing and the control of insulin secretion.

Biochem J 2015 Mar;466(2):203-18

*Section of Cell Biology, Division of Diabetes, Endocrinology and Metabolism, Imperial Centre for Translational and Experimental Medicine, Imperial College London, Du Cane Road, London W12 0NN, U.K.

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http://www.biochemj.org/content/ppbiochemj/466/2/203.full.pd
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http://biochemj.org/lookup/doi/10.1042/BJ20141384
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http://dx.doi.org/10.1042/BJ20141384DOI Listing
March 2015

Beta cell connectivity in pancreatic islets: a type 2 diabetes target?

Cell Mol Life Sci 2015 Feb 17;72(3):453-467. Epub 2014 Oct 17.

Section of Cell Biology, Department of Medicine, Imperial College London, Imperial Centre for Translational and Experimental Medicine, Hammersmith Hospital, Du Cane Road, London, W12 0NN, UK.

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http://dx.doi.org/10.1007/s00018-014-1755-4DOI Listing
February 2015

Cell biology. Pancreas micromanages autophagy.

Authors:
Guy A Rutter

Science 2015 Feb;347(6224):826-7

Section of Cell Biology and Functional Genomics, Division of Diabetes, Endocrinology and Metabolism, Imperial College London, Hammersmith Hospital, London W12 0NN, UK.

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http://dx.doi.org/10.1126/science.aaa6810DOI Listing
February 2015

SLC30A8 mutations in type 2 diabetes.

Diabetologia 2015 Jan 7;58(1):31-6. Epub 2014 Oct 7.

Section of Cell Biology, Division of Diabetes, Endocrinology and Metabolism, Department of Medicine, Imperial Centre for Translational and Experimental Medicine, Hammersmith Hospital, Imperial College London, Du Cane Road, London, W12 ONN, UK,

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http://link.springer.com/10.1007/s00125-014-3405-7
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January 2015

Rfx6 maintains the functional identity of adult pancreatic β cells.

Cell Rep 2014 Dec 11;9(6):2219-32. Epub 2014 Dec 11.

Institut de Génétique et de Biologie Moléculaire et Cellulaire, Institut National de la Santé et de la Recherche Médicale U964, Centre National de Recherche Scientifique UMR7104, Université de Strasbourg, Illkirch 67404, France. Electronic address:

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http://www.cell.com/cms/attachment/2033493489/2049507619/mmc
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http://linkinghub.elsevier.com/retrieve/pii/S221112471400999
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http://dx.doi.org/10.1016/j.celrep.2014.11.033DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4542305PMC
December 2014

Calcium signaling in pancreatic β-cells in health and in Type 2 diabetes.

Cell Calcium 2014 Nov 8;56(5):340-61. Epub 2014 Sep 8.

CNRS UMR-5203, Institut de Génomique Fonctionnelle, Montpellier, France; INSERM U661, Institut de Génomique Fonctionnelle, Montpellier, France; Institut de Génomique Fonctionnelle, Universités de Montpellier 1 et 2, Montpellier, France. Electronic address:

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http://dx.doi.org/10.1016/j.ceca.2014.09.001DOI Listing
November 2014

Mitochondria-associated endoplasmic reticulum membranes in insulin signaling.

Diabetes 2014 Oct;63(10):3163-5

Department of Morphology, Surgery and Experimental Medicine, Section of Pathology, Oncology and Experimental Biology, Laboratory for Technologies of Advanced Therapies, University of Ferrara, Ferrara, Italy

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http://dx.doi.org/10.2337/db14-0812DOI Listing
October 2014

Optical control of insulin release using a photoswitchable sulfonylurea.

Nat Commun 2014 Oct 14;5:5116. Epub 2014 Oct 14.

Department of Chemistry, Ludwig-Maximilians-Universität München, and Munich Center for Integrated Protein Science, Butenandtstrasse 5-13, 81377 München, Germany.

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http://www.nature.com/articles/ncomms6116
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http://dx.doi.org/10.1038/ncomms6116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4208094PMC
October 2014

Mitochondrial and ER-targeted eCALWY probes reveal high levels of free Zn2+.

ACS Chem Biol 2014 Sep 17;9(9):2111-20. Epub 2014 Jul 17.

Section of Cell Biology, Division of Medicine, and ‡National Heart and Lung Institute, Imperial College London , London, United Kingdom.

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http://dx.doi.org/10.1021/cb5004064DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6101202PMC
September 2014

Hypoxia lowers SLC30A8/ZnT8 expression and free cytosolic Zn2+ in pancreatic beta cells.

Diabetologia 2014 Aug 28;57(8):1635-44. Epub 2014 May 28.

Section of Cell Biology, Division of Diabetes, Endocrinology and Metabolism, Department of Medicine, Imperial College London, London, W12 ONN, UK.

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http://link.springer.com/10.1007/s00125-014-3266-0
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4079946PMC
August 2014

Roles of lncRNAs in pancreatic beta cell identity and diabetes susceptibility.

Front Genet 2014 1;5:193. Epub 2014 Jul 1.

Section of Cell Biology, Department of Medicine, Imperial Centre for Translational and Experimental Medicine, Imperial College London London, UK.

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http://dx.doi.org/10.3389/fgene.2014.00193DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4076741PMC
July 2014

Incretin-modulated beta cell energetics in intact islets of Langerhans.

Mol Endocrinol 2014 Jun 25;28(6):860-71. Epub 2014 Apr 25.

Section of Cell Biology, Division of Diabetes, Endocrinology and Metabolism, Department of Medicine (D.J.H, A.I.T., S.G.B., R.K.M., N.R.J., S.H., M.C.C., G.A.R.), Imperial College London, London W12 0NN, United Kingdom; Department of Endocrinology and Metabolism (M.B., P.M.), University of Pisa, 56126 Pisa, Italy; Cell Isolation and Transplantation Center, Department of Surgery (D.B.), Geneva University Hospitals and University of Geneva, 1205 Geneva, Switzerland; Oxford Centre for Diabetes, Endocrinology, & Metabolism (P.R.J., S.J.H.), University of Oxford, Oxford OX3 7LE, United Kingdom; NIHR Oxford Biomedical Research Centre (P.R.J., S.J.H.), Churchill Hospital, Oxford OX3 7LE, United Kingdom; and Nuffield Department of Surgical Sciences (P.R.J., S.J.H.), University of Oxford, Oxford OX3 9DU, United Kingdom.

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http://dx.doi.org/10.1210/me.2014-1038DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4042069PMC
June 2014

Hypothalamic glucagon signals through the KATP channels to regulate glucose production.

Mol Metab 2014 Apr 28;3(2):202-8. Epub 2013 Nov 28.

Toronto General Research Institute, University Health Network, Toronto, Canada ; Departments of Physiology, University of Toronto, Toronto, Canada ; Departments of Medicine, University of Toronto, Toronto, Canada ; Banting and Best Diabetes Centre, University of Toronto, Toronto, Canada.

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http://dx.doi.org/10.1016/j.molmet.2013.11.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3953686PMC
April 2014

Minireview: intraislet regulation of insulin secretion in humans.

Mol Endocrinol 2013 Dec 15;27(12):1984-95. Epub 2013 Nov 15.

Section Cell Biology, Department of Medicine, Imperial College London, London SW7 2AZ, United Kingdom. or Professor Guy A. Rutter, Section of Cell Biology, Department of Medicine, Imperial College London, London SW7 2AZ, United Kingdom. E-mail:

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http://dx.doi.org/10.1210/me.2013-1278DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5426601PMC
December 2013

Lanthanide(III) complexes of rhodamine-DO3A conjugates as agents for dual-modal imaging.

Inorg Chem 2013 Dec 4;52(24):14284-93. Epub 2013 Dec 4.

Department of Chemistry, Imperial College London , South Kensington, London SW7 2AZ, U.K.

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http://dx.doi.org/10.1021/ic402233gDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4024063PMC
December 2013