Publications by authors named "Gustavo Leone"

100Publications

Evaluating the efficacy of enzalutamide and the development of resistance in a preclinical mouse model of type-I endometrial carcinoma.

Neoplasia 2020 10 17;22(10):484-496. Epub 2020 Aug 17.

Department of Biochemistry and Molecular Biology, Hollings Cancer Center, Medical University of South Carolina, Charleston, SC, USA; Hollings Cancer Center, Medical University of South Carolina, Charleston, SC, USA. Electronic address:

View Article and Find Full Text PDF
October 2020

Cyclin D-CDK4/6 functions in cancer.

Adv Cancer Res 2020 2;148:147-169. Epub 2020 Apr 2.

Department of Cell and Molecular Pharmacology & Experimental Therapeutics, Medical University of South Carolina, Charleston, SC, United States; Hollings Cancer Center, Medical University of South Carolina, Charleston, SC, United States. Electronic address:

View Article and Find Full Text PDF
September 2020

PTEN in the Stroma.

Cold Spring Harb Perspect Med 2019 10 1;9(10). Epub 2019 Oct 1.

Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Hollings Cancer Center, Charleston, South Carolina 29425, USA.

View Article and Find Full Text PDF
October 2019

Modeling Human Cancer-induced Cachexia.

Cell Rep 2019 08;28(6):1612-1622.e4

Arthur G. James Comprehensive Cancer Center Cancer Cachexia Program, The Ohio State University, Columbus, OH 43210, USA; Department of Pediatrics, Medical University of South Carolina, Charleston, SC 29425, USA; Hollings Cancer Center, Medical University of South Carolina, Charleston, SC 29425, USA. Electronic address:

View Article and Find Full Text PDF
August 2019

Loss of PTEN Accelerates NKX3.1 Degradation to Promote Prostate Cancer Progression.

Cancer Res 2019 08 18;79(16):4124-4134. Epub 2019 Jun 18.

Departments of Medicine and of Pathology and Cell Biology, Columbia University Medical Center, Herbert Irving Comprehensive Cancer Center, Columbia University, New York, New York.

View Article and Find Full Text PDF
August 2019

Two Distinct E2F Transcriptional Modules Drive Cell Cycles and Differentiation.

Cell Rep 2019 06 23;27(12):3547-3560.e5. Epub 2019 May 23.

Department of Biochemistry and Molecular Biology, Hollings Cancer Center, Medical University of South Carolina, Charleston, SC 29425, USA. Electronic address:

View Article and Find Full Text PDF
June 2019

Cyclin F Controls Cell-Cycle Transcriptional Outputs by Directing the Degradation of the Three Activator E2Fs.

Mol Cell 2019 06 23;74(6):1264-1277.e7. Epub 2019 May 23.

Department of Biochemistry and Molecular Pharmacology, New York University School of Medicine, New York, NY 10016, USA; Perlmutter NYU Cancer Center, New York University School of Medicine, New York, NY 10016, USA; Howard Hughes Medical Institute, New York University School of Medicine, New York, NY 10016, USA. Electronic address:

View Article and Find Full Text PDF
June 2019

The broken cycle: E2F dysfunction in cancer.

Nat Rev Cancer 2019 06;19(6):326-338

Department of Biochemistry and Molecular Biology, Hollings Cancer Center, Medical University of South Carolina, Charleston, SC, USA.

View Article and Find Full Text PDF
June 2019

Sex-specific regulation of stress-induced fetal glucocorticoid surge by the mouse placenta.

Am J Physiol Endocrinol Metab 2019 07 16;317(1):E109-E120. Epub 2019 Apr 16.

Department for Obstetrics and Fetal Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

View Article and Find Full Text PDF
July 2019

Periostin/β1integrin interaction regulates p21-activated kinases in valvular interstitial cell survival and in actin cytoskeleton reorganization.

Biochim Biophys Acta Gen Subj 2019 05 10;1863(5):813-829. Epub 2019 Feb 10.

Department of Regenerative Medicine and Cell Biology, Medical University of South Carolina, Charleston, SC 29425, USA.. Electronic address:

View Article and Find Full Text PDF
May 2019

Crosstalk between PKCα and PI3K/AKT Signaling Is Tumor Suppressive in the Endometrium.

Cell Rep 2018 07;24(3):655-669

Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE 68198, USA. Electronic address:

View Article and Find Full Text PDF
July 2018

Endoreduplication of the mouse genome in the absence of ORC1.

Genes Dev 2018 07;32(13-14):978-990

Department of Biochemistry and Molecular Biology, Hollings Cancer Center, Medical University of South Carolina, Charleston, South Carolina 29425, USA.

View Article and Find Full Text PDF
July 2018

-mediated regulation of E2F1 is required for CML stem/progenitor cell survival.

Blood 2018 04 5;131(14):1532-1544. Epub 2018 Feb 5.

Paul O'Gorman Leukaemia Research Centre, Institute of Cancer Sciences, College of Medical, Veterinary, and Life Sciences, University of Glasgow, Glasgow, United Kingdom.

View Article and Find Full Text PDF
April 2018

Generation of a pancreatic cancer model using a Pdx1-Flp recombinase knock-in allele.

PLoS One 2017 21;12(9):e0184984. Epub 2017 Sep 21.

Hollings Cancer Center, Medical University of South Carolina, Charleston, South Carolina, United States of America.

View Article and Find Full Text PDF
October 2017

Discovery of Stromal Regulatory Networks that Suppress Ras-Sensitized Epithelial Cell Proliferation.

Dev Cell 2017 05;41(4):392-407.e6

Solid Tumor Biology Program, Comprehensive Cancer Center, The Ohio State University, Columbus, OH 43210, USA; Department of Molecular Genetics, The Ohio State University, 484 West 12th Avenue, Columbus, OH 43210, USA; Department of Cancer Biology and Genetics, McGill University, Montreal, QC H3A 1A1, Canada; Hollings Cancer Center, Medical University of South Carolina, Hollings Cancer Center 124J, 86 Jonathan Lucas Street, Charleston, SC 29425, USA. Electronic address:

View Article and Find Full Text PDF
May 2017

Stromal PDGFR-α Activation Enhances Matrix Stiffness, Impedes Mammary Ductal Development, and Accelerates Tumor Growth.

Neoplasia 2017 Jun 11;19(6):496-508. Epub 2017 May 11.

The Comprehensive Cancer Center, The Ohio State University, Columbus, OH 43210, USA; Department of Cancer Biology and Genetics, The Ohio State University, Columbus, OH 43210, USA. Electronic address:

View Article and Find Full Text PDF
June 2017

annoPeak: a web application to annotate and visualize peaks from ChIP-seq/ChIP-exo-seq.

Bioinformatics 2017 May;33(10):1570-1571

Department of Molecular Virology, Immunology and Medical Genetics College of Medicine, The Ohio State University, Columbus, OH, USA.

View Article and Find Full Text PDF
May 2017

Transcriptome regulation and chromatin occupancy by E2F3 and MYC in mice.

Sci Data 2016 Feb 16;3:160008. Epub 2016 Feb 16.

Department of Molecular Virology, Immunology and Medical Genetics, College of Medicine, Columbus, Ohio 43210, USA.

View Article and Find Full Text PDF
February 2016

FGFR and PTEN signaling interact during lens development to regulate cell survival.

Dev Biol 2016 Feb 5;410(2):150-163. Epub 2016 Jan 5.

Department of Biology, Cell Molecular and Structural Biology Graduate Program, Miami University, Oxford, OH, USA. Electronic address:

View Article and Find Full Text PDF
February 2016

The Spectrum of E2F in Liver Disease--Mediated Regulation in Biology and Cancer.

J Cell Physiol 2016 Jul 2;231(7):1438-49. Epub 2016 Feb 2.

Department of Molecular Virology, Immunology and Medical Genetics, College of Medicine, Columbus, Ohio.

View Article and Find Full Text PDF
July 2016

WWP2 and its association with PTEN in endometrial cancer.

Gynecol Oncol Rep 2015 Aug 3;13:26-9. Epub 2015 Jun 3.

Human Cancer Genetics, The Ohio State University College of Medicine, United States.

View Article and Find Full Text PDF
August 2015

Noncatalytic PTEN missense mutation predisposes to organ-selective cancer development in vivo.

Genes Dev 2015 Aug;29(16):1707-20

Solid Tumor Biology Program, James Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio 43210, USA; Department of Molecular Genetics, College of Arts and Sciences, The Ohio State University, Columbus, Ohio 43210, USA; Department of Molecular Virology, Immunology, and Medical Genetics, College of Medicine, The Ohio State University, Columbus, Ohio 43210, USA;

View Article and Find Full Text PDF
August 2015

Redeployment of Myc and E2f1-3 drives Rb-deficient cell cycles.

Nat Cell Biol 2015 Aug 20;17(8):1036-48. Epub 2015 Jul 20.

1] Department of Molecular Virology, Immunology and Medical Genetics, College of Medicine, The Ohio State University, Columbus, Ohio 43210, USA [2] Department of Molecular Genetics, College of Biological Sciences, The Ohio State University, Columbus, Ohio 43210, USA [3] Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio 43210, USA.

View Article and Find Full Text PDF
August 2015

PTEN is a negative regulator of NK cell cytolytic function.

J Immunol 2015 Feb 16;194(4):1832-40. Epub 2015 Jan 16.

Medical Scientist Training Program and Biomedical Sciences Graduate Program, The Ohio State University, Columbus, OH 43210; The Comprehensive Cancer Center and Arthur G. James Cancer Hospital and Richard J. Solove Research Institute, The Ohio State University, Columbus, OH 43210; Department of Molecular Virology, Immunology, and Medical Genetics, The Ohio State University, Columbus, OH 43210; and Division of Hematology, Department of Internal Medicine, The Ohio State University, Columbus, OH 43210.

View Article and Find Full Text PDF
February 2015

Cited2 is required in trophoblasts for correct placental capillary patterning.

Dev Biol 2014 Aug 5;392(1):62-79. Epub 2014 May 5.

Developmental and Stem Cell Biology Division, Victor Chang Cardiac Research Institute, Sydney, Australia; St. Vincent׳s Clinical School, Faculty of Medicine, University of New South Wales, Sydney, Australia; School of Biotechnology and Biomolecular Sciences, Faculty of Science, University of New South Wales, Sydney, Australia. Electronic address:

View Article and Find Full Text PDF
August 2014

HO-3867, a safe STAT3 inhibitor, is selectively cytotoxic to ovarian cancer.

Cancer Res 2014 Apr 3;74(8):2316-27. Epub 2014 Mar 3.

Authors' Affiliations: Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, Comprehensive Cancer Center; Center for Childhood Cancer, Nationwide Children's Hospital; Department of Molecular Virology, Immunology and Medical Genetics, The Ohio State University Wexner Medical Center; EPR Imaging Center, Geisel School of Medicine, Dartmouth, New Hampshire; and Institute of Organic and Medicinal Chemistry, University of Pécs, Pécs, Hungary.

View Article and Find Full Text PDF
April 2014

Stat5 regulates the phosphatidylinositol 3-kinase/Akt1 pathway during mammary gland development and tumorigenesis.

Mol Cell Biol 2014 Apr 27;34(7):1363-77. Epub 2014 Jan 27.

Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, Nebraska, USA.

View Article and Find Full Text PDF
April 2014

Opposing regulation of Sox2 by cell-cycle effectors E2f3a and E2f3b in neural stem cells.

Cell Stem Cell 2013 Apr 14;12(4):440-52. Epub 2013 Mar 14.

Department of Cellular and Molecular Medicine, University of Ottawa, 451 Smyth Road, Ottawa, ON K1H 8M5, Canada.

View Article and Find Full Text PDF
April 2013

Loss of fibroblast HIF-1α accelerates tumorigenesis.

Cancer Res 2012 Jul 3;72(13):3187-95. Epub 2012 May 3.

Molecular Biology Section, Division of Biological Sciences, Department of Medicine, University of California, San Diego, La Jolla, California, USA.

View Article and Find Full Text PDF
July 2012

Atypical E2F repressors and activators coordinate placental development.

Dev Cell 2012 Apr;22(4):849-62

Solid Tumor Biology Program, Department of Molecular Virology, Immunology and Medical Genetics, Human Cancer Genetics Program, Comprehensive Cancer Center, College of Medicine and Public Health, The Ohio State University, Columbus, OH 43210, USA.

View Article and Find Full Text PDF
April 2012

The retinoblastoma tumor suppressor regulates a xenobiotic detoxification pathway.

PLoS One 2011 12;6(10):e26019. Epub 2011 Oct 12.

Department of Biological Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America.

View Article and Find Full Text PDF
February 2012

Non-parametric population analysis of cellular phenotypes.

Med Image Comput Comput Assist Interv 2011 ;14(Pt 2):343-51

Dept. of Computer Science and Eng., The Ohio State University, USA.

View Article and Find Full Text PDF
November 2011

Identifying nuclear phenotypes using semi-supervised metric learning.

Inf Process Med Imaging 2011 ;22:398-410

Dept. of Computer Science and Engg., The Ohio State University, USA.

View Article and Find Full Text PDF
August 2011

Pten in the breast tumor microenvironment: modeling tumor-stroma coevolution.

Cancer Res 2011 Feb 8;71(4):1203-7. Epub 2011 Feb 8.

Department of Molecular and Cellular Biochemistry, College of Medicine, The Ohio State University, Columbus, Ohio, USA.

View Article and Find Full Text PDF
February 2011

Cell proliferation in the absence of E2F1-3.

Dev Biol 2011 Mar 23;351(1):35-45. Epub 2010 Dec 23.

Department of Molecular Virology, Immunology and Medical Genetics, Comprehensive Cancer Center, College of Medicine, The Ohio State University, Columbus, OH 43210, USA.

View Article and Find Full Text PDF
March 2011

E2f1-3 are critical for myeloid development.

J Biol Chem 2011 Feb 28;286(6):4783-95. Epub 2010 Nov 28.

College of Medicine and Public Health, Ohio State University, Columbus, Ohio 43210, USA.

View Article and Find Full Text PDF
February 2011

Allele-specific tumor spectrum in pten knockin mice.

Proc Natl Acad Sci U S A 2010 Mar 1;107(11):5142-7. Epub 2010 Mar 1.

Department of Molecular Genetics, College of Biological Sciences, Comprehensive Cancer Center, Ohio State University, Columbus, OH 43210, USA.

View Article and Find Full Text PDF
March 2010

An ets2-driven transcriptional program in tumor-associated macrophages promotes tumor metastasis.

Cancer Res 2010 Feb 9;70(4):1323-33. Epub 2010 Feb 9.

Department of Molecular and Cellular Biochemistry, Center for Biostatistics, College of Public Health, and Tumor Microenvironment Program, Comprehensive Cancer Center, Ohio State University, Columbus, Ohio 43210, USA.

View Article and Find Full Text PDF
February 2010

Division and apoptosis of E2f-deficient retinal progenitors.

Nature 2009 Dec;462(7275):925-9

Toronto Western Research Institute, University Health Network, Department of Ophthalmology, and Laboratory Medicine and Pathobiology, University of Toronto, Ontario M5T 2S8, Canada.

View Article and Find Full Text PDF
December 2009

Erk1 and Erk2 regulate endothelial cell proliferation and migration during mouse embryonic angiogenesis.

PLoS One 2009 Dec 14;4(12):e8283. Epub 2009 Dec 14.

Department of Molecular and Cellular Biochemistry, The Ohio State University, Columbus, Ohio, United States of America.

View Article and Find Full Text PDF
December 2009

E2F3 is a mediator of DNA damage-induced apoptosis.

Mol Cell Biol 2010 Jan 16;30(2):524-36. Epub 2009 Nov 16.

Department of Biochemistry, University of Mississippi Medical Center, 2500 North State Street, Jackson, MS 39216, USA.

View Article and Find Full Text PDF
January 2010

Synthetic cannabinoid receptor agonists inhibit tumor growth and metastasis of breast cancer.

Mol Cancer Ther 2009 Nov 3;8(11):3117-29. Epub 2009 Nov 3.

Department of Pathology, Ohio State University Medical Center, Columbus, OH 43210, USA.

View Article and Find Full Text PDF
November 2009

Emerging roles of E2Fs in cancer: an exit from cell cycle control.

Nat Rev Cancer 2009 Nov;9(11):785-97

Human Cancer Genetics Program, Department of Molecular Virology, Immunology and Medical Genetics and Department of Molecular Genetics, The Ohio State University, Columbus, Ohio 43210, USA.

View Article and Find Full Text PDF
November 2009

Genomic alterations in tumor stroma.

Cancer Res 2009 Sep 25;69(17):6759-64. Epub 2009 Aug 25.

Genomic Medicine Institute, Lerner Research Institute and Taussig Cancer Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA.

View Article and Find Full Text PDF
September 2009

Atypical E2Fs: new players in the E2F transcription factor family.

Trends Cell Biol 2009 Mar 7;19(3):111-8. Epub 2009 Feb 7.

Department of Plant Systems Biology, Flanders Institute for Biotechnology (VIB), 9052 Gent, Belgium.

View Article and Find Full Text PDF
March 2009

E2f3a and E2f3b contribute to the control of cell proliferation and mouse development.

Mol Cell Biol 2009 Jan 17;29(2):414-24. Epub 2008 Nov 17.

Human Cancer Genetics Program, Department of Molecular Virology, Immunology and Medical Genetics, The Ohio State University, Columbus, Ohio 43210, USA.

View Article and Find Full Text PDF
January 2009

Tensor classification of N-point correlation function features for histology tissue segmentation.

Med Image Anal 2009 Feb 25;13(1):156-66. Epub 2008 Jul 25.

Department of Computer Science and Engineering, The Ohio State University, Columbus, OH 43210, USA.

View Article and Find Full Text PDF
February 2009

Mouse development with a single E2F activator.

Nature 2008 Aug 25;454(7208):1137-41. Epub 2008 Jun 25.

Department of Molecular Genetics, College of Biological Sciences, The Ohio State University, Columbus, Ohio 43210, USA.

View Article and Find Full Text PDF
August 2008

An imaging workflow for characterizing phenotypical change in large histological mouse model datasets.

J Biomed Inform 2008 Dec 7;41(6):863-73. Epub 2008 Apr 7.

Department of Biomedical Informatics, The Ohio State University, 3190 Graves Hall, 333 West 10th Avenue, Columbus, OH 43210, USA.

View Article and Find Full Text PDF
December 2008

Reconstruction of cellular biological structures from optical microscopy data.

IEEE Trans Vis Comput Graph 2008 Jul-Aug;14(4):863-76

Department of Computer Science and Engineering, Ohio State University, Columbus, OH 43210, USA.

View Article and Find Full Text PDF
July 2008

Targeted deletion of Prkar1a reveals a role for protein kinase A in mesenchymal-to-epithelial transition.

Cancer Res 2008 Apr;68(8):2671-7

Human Cancer Genetics Program, Department of Molecular Virology, Immunology and Medical Genetics, The Ohio State University, Columbus, Ohio, USA.

View Article and Find Full Text PDF
April 2008

Identification of novel posttranscriptional targets of the BCR/ABL oncoprotein by ribonomics: requirement of E2F3 for BCR/ABL leukemogenesis.

Blood 2008 Jan 9;111(2):816-28. Epub 2007 Oct 9.

Human Cancer Genetics Program, Department of Molecular Virology, Immunology and Medical Genetics and Comprehensive Cancer Center, Ohio State University, Columbus, USA.

View Article and Find Full Text PDF
January 2008

Detection and visualization of surface-pockets to enable phenotyping studies.

IEEE Trans Med Imaging 2007 Sep;26(9):1283-90

Department of Computer Science and Engineering, The Ohio State University, Columbus, OH 43210, USA.

View Article and Find Full Text PDF
September 2007

Specific tumor suppressor function for E2F2 in Myc-induced T cell lymphomagenesis.

Proc Natl Acad Sci U S A 2007 Sep 19;104(39):15400-5. Epub 2007 Sep 19.

Human Cancer Genetics Program, Department of Molecular Virology, Immunology, and Medical Genetics, College of Medicine and Public Health, Ohio State University, Columbus, OH 43210, USA.

View Article and Find Full Text PDF
September 2007

Intestinal hyperplasia induced by simian virus 40 large tumor antigen requires E2F2.

J Virol 2007 Dec 12;81(23):13191-9. Epub 2007 Sep 12.

Department of Biological Sciences, University of Pittsburgh, Pittsburgh, PA 15260, USA.

View Article and Find Full Text PDF
December 2007

Rb-mediated neuronal differentiation through cell-cycle-independent regulation of E2f3a.

PLoS Biol 2007 Jul 3;5(7):e179. Epub 2007 Jul 3.

Genetics and Development Division, Toronto Western Research Institute, University Health Network, University of Toronto, Ontario, Canada.

View Article and Find Full Text PDF
July 2007

Unique requirement for Rb/E2F3 in neuronal migration: evidence for cell cycle-independent functions.

Mol Cell Biol 2007 Jul 23;27(13):4825-43. Epub 2007 Apr 23.

Department of Cellular and Molecular Medicine, Ottawa Health Research Institute, University of Ottawa, Ottawa, ON, Canada.

View Article and Find Full Text PDF
July 2007

Rb is critical in a mammalian tissue stem cell population.

Genes Dev 2007 Jan;21(1):85-97

Human Cancer Genetics Program, Department of Molecular Virology, Immunology and Medical Genetics, College of Medicine, The Ohio State University, Columbus, Ohio 43210, USA.

View Article and Find Full Text PDF
January 2007

E2f1, E2f2, and E2f3 control E2F target expression and cellular proliferation via a p53-dependent negative feedback loop.

Mol Cell Biol 2007 Jan;27(1):65-78

Human Cancer Genetics program, Department of Molecular Virology, Immunology and Medical Genetics, and Comprehensive Cancer Center, The Ohio State University, 410 W. 12th Avenue, Columbus, OH 43210, USA.

View Article and Find Full Text PDF
January 2007

Control of the p53-p21CIP1 Axis by E2f1, E2f2, and E2f3 is essential for G1/S progression and cellular transformation.

J Biol Chem 2006 Nov 27;281(47):36124-31. Epub 2006 Sep 27.

Human Cancer Genetics Program, Department of Molecular Virology, Immunology, and Medical Genetics, Comprehensive Cancer Center, Ohio State University, Columbus, Ohio 43210, USA.

View Article and Find Full Text PDF
November 2006

E2F-8: an E2F family member with a similar organization of DNA-binding domains to E2F-7.

Oncogene 2005 Jul;24(31):5000-4

Division of Biochemistry and Molecular Biology, University of Glasgow, Glasgow, G12 8QQ, UK.

View Article and Find Full Text PDF
July 2005

Cloning and characterization of mouse E2F8, a novel mammalian E2F family member capable of blocking cellular proliferation.

J Biol Chem 2005 May 18;280(18):18211-20. Epub 2005 Feb 18.

Human Cancer Genetics Program, Department of Molecular Virology, Immunology and Medical Genetics, and Department of Molecular Genetics, Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio 43210, USA.

View Article and Find Full Text PDF
May 2005

Retinoblastoma promotes definitive erythropoiesis by repressing Id2 in fetal liver macrophages.

Nature 2004 Dec;432(7020):1040-5

Institute for Cancer Genetics, College of Physicians and Surgeons of Columbia University, New York, New York 10032, USA.

View Article and Find Full Text PDF
December 2004

Aberrant regulation of survivin by the RB/E2F family of proteins.

J Biol Chem 2004 Sep 22;279(39):40511-20. Epub 2004 Jul 22.

Columbus Children's Research Institute, College of Medicine and Public Health, Ohio State University, 43210, USA.

View Article and Find Full Text PDF
September 2004