Dr Gurudeeban Selvaraj, PhD - Henan University of Technology - Faculty

Dr Gurudeeban Selvaraj

PhD

Henan University of Technology

Faculty

Zhengzhou, Henan | China

Main Specialties: Biotechnology, Endocrinology Diabetes & Metabolism, Infectious Disease, Oncology, Pharmacology

Additional Specialties: Network Pharmacology

ORCID logohttps://orcid.org/0000-0002-7223-3853

Dr Gurudeeban Selvaraj, PhD - Henan University of Technology - Faculty

Dr Gurudeeban Selvaraj

PhD

Introduction

Dr. Gurudeeban Selvaraj, M.Sc., Ph.D., PDF. is an Interdisciplinary Sciences-Computational Life Sciences researcher from INDIA. Currently concentrating application of network pharmacology especially on gene expression of coding and noncoding RNAs, gene regulatory networks, protein-protein interaction network on lung cancer research. In addition, working on data science related to clinical data with statistical analysis.

Primary Affiliation: Henan University of Technology - Zhengzhou, Henan , China

Specialties:

Additional Specialties:

Research Interests:

Education

Dec 2009 - Apr 2014
Annamalai University Faculty of Marine Sciences
Ph.D. in Marine Biotechnology
Centre of Advanced Study in Marine Biology
Jul 2006 - May 2008
Annamalai University Faculty of Marine Sciences
M.Sc. in Marine Biotechnology
Centre of Advanced Study in Marine Biology
Jun 2003 - May 2006
Bharathidasn College of Arts & Science (Bharathiar University)
B.Sc. in Biochemistry
Biochemistry

Experience

Jul 2017 - Jul 2017
Henan University of Technology
Faculty
Centre for Interdisciplinary Sciences-Computational Life Sciences College of Food Science and Technology
Sep 2014 - Apr 2016
Istanbul Medeniyet Universitesi
Postdoctoral Research Associate
Molecular Biology & Genetics
Dec 2009 - Apr 2014
Annamalai University Faculty of Marine Sciences
Project Fellow
Faculty of Marine Science
Jun 2008 - Nov 2009
Bannari Amman Group
Chemist (Trainee)
Distillery

Publications

32Publications

1374Reads

119Profile Views

41PubMed Central Citations

Molecular docking and molecular dynamics simulation studies to identify potent AURKA inhibitors: assessing the performance of density functional theory, MM-GBSA and mass action kinetics calculations.

J Biomol Struct Dyn 2019 Oct 14:1-11. Epub 2019 Oct 14.

State Key Laboratory of Microbial Metabolism, School of Life Sciences and Biotechnology, and Joint Laboratory of International Cooperation in Metabolic and Developmental Sciences, Ministry of Education, Shanghai Jiao Tong University , Shanghai , China.

View Article

Download full-text PDF

Source
https://www.tandfonline.com/doi/full/10.1080/07391102.2019.1
Publisher Site
http://dx.doi.org/10.1080/07391102.2019.1674695DOI Listing
October 2019
2 Reads
2.983 Impact Factor

Ion channels as therapeutic targets for type 1 diabetes mellitus.

Curr Drug Targets 2019 09 20. Epub 2019 Sep 20.

Department of Bioinformatics, Computer Aided Drug Design, and Molecular Modeling Lab, Science Block, Alagappa University, Karaikudi, Tamil Nadu, , 630004 India

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2174/1389450119666190920152249DOI Listing
September 2019
2 Reads
3.021 Impact Factor

Viewing the Emphasis on State-of-the-Art Magnetic Nanoparticles: Synthesis, Physical Properties, and Applications in Cancer Theranostics.

Curr Pharm Des 2019 ;25(13):1505-1523

Center of Interdisciplinary Sciences-Computational Life Sciences, College of Food Science and Engineering, Henan University of Technology, Zhengzhou High-tech Industrial Development Zone, 100 Lianhua Street, Zhengzhou, Henan 450001, China.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2174/1381612825666190523105004DOI Listing
January 2019
7 Reads
3.452 Impact Factor

Exploring the Papillomaviral Proteome to Identify Potential Candidates for a Chimeric Vaccine against Cervix Papilloma Using Immunomics and Computational Structural Vaccinology.

Viruses 2019 01 15;11(1). Epub 2019 Jan 15.

Center of Interdisciplinary Science-Computational Life Sciences, College of Food Science and Engineering, Henan University of Technology, Zhengzhou 450001, China.

The human papillomavirus (HPV) 58 is considered to be the second most predominant genotype in cervical cancer incidents in China. HPV type-restriction, non-targeted delivery, and the highcost of existing vaccines necessitate continuing research on the HPV vaccine. We aimed to explore the papillomaviral proteome in order to identify potential candidates for a chimeric vaccine against cervix papilloma using computational immunology and structural vaccinology approaches. Two overlapped epitope segments (23?36) and (29?42) from the N-terminal region of the HPV58 minor capsid protein L2 are selected as capable of inducing both cellular and humoral immunity. In total, 318 amino acid lengths of the vaccine construct SGD58 contain adjuvants (Flagellin and RS09), two Th epitopes, and linkers. SGD58 is a stable protein that is soluble, antigenic, and non-allergenic. Homology modeling and the structural refinement of the best models of SGD58 and TLR5 found 96.8% and 93.9% favored regions in Rampage, respectively. The docking results demonstrated a HADDOCK score of -62.5 ± 7.6, the binding energy (-30 kcal/mol) and 44 interacting amino acid residues between SGD58-TLR5 complex. The docked complex are stable in 100 ns of simulation. The coding sequences of SGD58 also show elevated gene expression in with 1.0 codon adaptation index and 59.92% glycine-cysteine content. We conclude that SGD58 may prompt the creation a vaccine against cervix papilloma.

View Article

Download full-text PDF

Source
http://www.mdpi.com/1999-4915/11/1/63
Publisher Site
http://dx.doi.org/10.3390/v11010063DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6357041PMC
January 2019
69 Reads
3.761 Impact Factor

Designing of CD8 and CD8-overlapped CD4 epitope vaccine by targeting late and early proteins of human papillomavirus.

Biologics 2018 2;12:107-125. Epub 2018 Oct 2.

Centre of Interdisciplinary Science - Computational Life Sciences, College of Food Science and Engineering, Henan University of Technology, Zhengzhou, China,

View Article

Download full-text PDF

Source
https://www.dovepress.com/designing-of-cd8-and-cd8-overlappe
Publisher Site
http://dx.doi.org/10.2147/BTT.S177901DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6174296PMC
October 2018
75 Reads

Identification of target gene and prognostic evaluation for lung adenocarcinoma using gene expression meta-analysis, network analysis and neural network algorithms.

J Biomed Inform 2018 10 6;86:120-134. Epub 2018 Sep 6.

Center of Interdisciplinary Sciences-Computational Life Sciences, College of Food Science and Engineering, Henan University of Technology, Zhengzhou, China; College of Science, Henan University of Technology, Zhengzhou, China; Department of Bioinformatics, The State Key Laboratory of Microbial Metabolism, College of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, China. Electronic address:

Background: Lung adenocarcinoma (LUAD) is a heterogeneous disease with poor survival in the advanced stage and a high incidence rate in the world. Novel drug targets are urgently required to improve patient treatment. Therefore, we aimed to identify therapeutic targets for LUAD based on protein-protein and protein-drug interaction network analysis with neural network algorithms using mRNA expression profiles.

Results: A comprehensive meta-analysis of selective non-small cell lung cancer (NSCLC) mRNA expression profile datasets from Gene Expression Omnibus were used to identify potential biomarkers and the molecular mechanisms related to the prognosis of NSCLC patients. Using the Network Analyst tool, based on combined effect size (ES) methods, we recognized 6566 differentially expressed genes (DEGs), which included 3036 downregulated and 3530 upregulated genes linked to NSCLC patient survival. ClueGO, a Cytoscape plugin, was exploited to complete the function and pathway enrichment analysis, which disclosed "regulated exocytosis", "purine nucleotide binding", "pathways in cancer", and "cell cycle" between exceptionally supplemented terms. Enrichr, a web tool examination, demonstrated "early growth response protein 1 (EGR-1)", "hepatocyte nuclear factor 4? (HNF4A)", "mitogen-activated protein kinase 14 (MAP3K14)", and "cyclin-dependent kinase 1 (CDK1)" to be among the most prevalent TFs and kinases associated with NSCLC. Our meta-analysis identified that MAPK1 and aurora kinase (AURKA) are the most obvious class of hub nodes. Furthermore, protein-drug interaction network and neural network algorithms identified candidate drugs such as phosphothreonine and 4-(4-methylpiperazin-1-yl)-n-[5-(2-thienylacetyl)-1,5-dihydropyrrolo[3,4-c]pyrazol-3-yl] benzamide and for the targets MAPK1 and AURKA, respectively.

Conclusion: Our study has identified novel candidate biomarkers, pathways, transcription factors (TFs), and kinases associated with NSCLC prognosis, as well as drug candidates, which may assist treatment strategy for NSCLC patients.

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S15320464183017
Publisher Site
http://dx.doi.org/10.1016/j.jbi.2018.09.004DOI Listing
October 2018
89 Reads
3.120 Impact Factor

Prognostic Impact of Tissue Inhibitor of Metalloproteinase-1 in Non-Small Cell Lung Cancer: Systematic Review and Meta-Analysis.

Curr Med Chem 2018 09 3. Epub 2018 Sep 3.

Center of Interdisciplinary Sciences-Computational Life Sciences, College of Food Science and Engineering, Henan University of Technology, Zhengzhou High-tech Industrial Development Zone, 100 Lianhua Street, Zhengzhou, Henan 450001, China.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2174/0929867325666180904114455DOI Listing
September 2018
44 Reads
3.853 Impact Factor

Towards the low-sensitive and high-energetic co-crystal explosive CL-20/TNT: from intermolecular interactions to structures and properties.

Phys Chem Chem Phys 2018 Jun;20(25):17253-17261

National Key Laboratory for Shock Wave and Detonation Physics Research, Institute of Fluid Physics, Chinese Academy of Engineering Physics, Mianyang 621999, China.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1039/c8cp01841cDOI Listing
June 2018
44 Reads
4.493 Impact Factor

Detoxification of aflatoxins on prospective approach: effect on structural, mechanical, and optical properties under pressures.

Interdiscip Sci 2018 Jun 27;10(2):311-319. Epub 2017 Dec 27.

Centre of Food Science and Engineering, School of Chemistry, Henan University of Technology, Zhengzhou, 450001, China.

Aflatoxins are sequential of derivatives of coumarin and dihydrofuran with similar chemical structures and well-known carcinogenic agent. Many studies performed to detoxify aflatoxins, but the result is not ideal. Therefore, we studied structural, infrared spectrum, mechanical, and optical properties of these compounds in the aim of perspective physics. Mulliken charge distributions and infrared spectral analysis performed to understand the structural difference between the basic types of aflatoxins. In addition, the effect of pressure, different polarized, and incident directions on their structural changes was determined. It is found that AFB is most stable structure among four basic types aflatoxins (AFB, AFB, AFG, and AFG), and IR spectra are analyzed to exhibit the difference on structures of them. The mechanical properties of AFB indicate that the structure of this toxin can be easily changed by pressure. The real [Formula: see text] and imaginary [Formula: see text] parts of the dielectric function, and the absorption coefficient [Formula: see text] and energy loss spectrum [Formula: see text] were also obtained under different polarized and incident directions. Furthermore, biological experiments needed to support the toxic level of AFB using optical technologies.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s12539-017-0278-8DOI Listing
June 2018
237 Reads
0.796 Impact Factor

Cancer Immunoinformatics: A Promising Era in the Development of Peptide Vaccines for Human Papillomavirus-induced Cervical Cancer.

Curr Pharm Des 2018 ;24(32):3791-3817

Center of Interdisciplinary Sciences-Computational Life Sciences, College of Food Science and Engineering, Henan University of Technology, Zhengzhou High-tech Industrial Development Zone, 100 Lianhua Street, Zhengzhou, Henan 450001, China.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2174/1381612824666181106094133DOI Listing
January 2018
76 Reads
3.452 Impact Factor

Effect of Glycosin alkaloid from Rhizophora apiculata in non-insulin dependent diabetic rats and its mechanism of action: In vivo and in silico studies.

Phytomedicine 2016 Jun 24;23(6):632-40. Epub 2016 Mar 24.

Centre of Advanced Study in Marine Biology, Faculty of Marine Sciences, Annamalai University, Parangipettai 608502, Tamil Nadu, India.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.phymed.2016.03.004DOI Listing
June 2016
229 Reads
3.126 Impact Factor

Influence of Rhizophora apiculata Blume extracts on α-glucosidase: Enzyme kinetics and molecular docking studies

Biocatalysis and Agricultural Biotechnology Volume 4, Issue 4, October 2015, Pages 653-660

Biocatalysis and Agricultural Biotechnology

https://doi.org/10.1016/j.bcab.2015.07.005

View Article
October 2015
51 Reads

Molecular docking studies on potential PPAR-γ agonist from Rhizophora apiculata

Bangladesh Journal of Pharmacology, 9(3), 298-302.

Bangladesh Journal of Pharmacology

https://doi.org/10.3329/bjp.v9i3.18915

View Article
May 2014

Impact Factor 1.031

11 Reads

Anti-nociceptive effect in mice of thillai flavonoid rutin.

Biomed Environ Sci 2014 Apr;27(4):295-9

Centre of Advanced Study in Marine Biology, Faculty of Marine Sciences, Annamalai University, Parangipettai 608502, Tamil Nadu, India.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3967/bes2014.052DOI Listing
April 2014
287 Reads
1.653 Impact Factor

Phylogeny of Indian rhizophoraceae based on the molecular data from chloroplast tRNA(LEU)UAA intergenic sequences.

Pak J Biol Sci 2013 Oct;16(20):1130-7

Marine Floral Biotechnology Laboratory, Centre of Advanced Study in Marine Biology, Faculty of Marine Sciences, Annamalai University, Parangipettai 608502, Tamil Nadu, India.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3923/pjbs.2013.1130.1137DOI Listing
October 2013
14 Reads

Direct organogenesis of seaside heliotrope (Heliotropium crassavicum) using stem explants.

Pak J Biol Sci 2013 Oct;16(20):1216-9

Marine Plant Biotechnology Laboratory, Centre of Advanced Study in Marine Biology, Faculty of Marine Sciences, Annamalai University, Parangipettai, Tamil Nadu, 608502, India.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3923/pjbs.2013.1216.1219DOI Listing
October 2013
56 Reads

Dipeptidyl peptidase IV inhibitors derived from a mangrove flora Rhizophora mucronata: An in silico approach

Bangladesh Journal of Pharmacology, 7(3), 203-210

Bangladesh J Pharmacol

https://doi.org/10.3329/bjp.v7i3.11636

View Article
October 2012

14 Citations

Impact Factor 1.050

7 Reads

Toxicity Study of Silver Nanoparticles Synthesized from Suaeda monoica on Hep-2 Cell Line.

Avicenna J Med Biotechnol 2012 Jan;4(1):35-9

Marine Medicinal Plant Biotechnology Laboratory, Faculty of Marine Sciences, Annamalai University, Parangipettai, Tamil Nadu, India.

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3558200PMC
January 2012
86 Reads

Antidiabetic effect of a black mangrove species Aegiceras corniculatum in alloxan-induced diabetic rats.

J Adv Pharm Technol Res 2012 Jan;3(1):52-6

Marine Medicinal Plant Biotechnology Laboratory, Centre of Advanced Study in Marine Biology, Faculty of Marine Sciences, Annamalai University, Parangipettai, Tamil Nadu, India.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4103/2231-4040.93560DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3312728PMC
January 2012
40 Reads

Biomedical potential of silver nanoparticles synthesized from calli cells of Citrullus colocynthis (L.) Schrad.

J Nanobiotechnology 2011 Sep 26;9:43. Epub 2011 Sep 26.

Centre of Advanced Study in Marine Biology, Faculty of Marine Sciences, Annamalai University, Parangipettai, India.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/1477-3155-9-43DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3203035PMC
September 2011
16 Reads
4.078 Impact Factor

Standardization of DNA isolation and PCR protocol for RAPD analysis of Suaeda sp

Asian Journal of Biotechnology, 3: 486-492.

Asian Journal of Biotechnology

10.3923/ajbkr.2011.486.492

View Article
July 2011

15 Citations

7 Reads

Top co-authors

Dong-Qing Wei
Dong-Qing Wei

Shanghai Jiaotong University

11
Satyavani Kaliamurthi
Satyavani Kaliamurthi

Henan University of Technology

11
Keren Gu
Keren Gu

Henan University of Technology

6
Abbas Khan
Abbas Khan

University of Peshawar

2
Guang-Fu Ji
Guang-Fu Ji

Institute of Fluid Physics

2
Sathishkumar Chinnasamy
Sathishkumar Chinnasamy

Alagappa University

2
Thangavel Balasubramanian
Thangavel Balasubramanian

Annamalai University

2