Guri Giaever

Guri Giaever

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Interactively AUDIT Your Growth Curves with a Suite of R Packages.

G3 (Bethesda) 2020 Jan 23. Epub 2020 Jan 23.

University of British Columbia

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http://dx.doi.org/10.1534/g3.119.400898DOI Listing
January 2020

Network dynamics of the yeast methyltransferome.

Microb Cell 2019 Jul 9;6(8):356-369. Epub 2019 Jul 9.

Department of Pharmaceutical Sciences, University of British Columbia, Vancouver, BC, Canada V6T 1Z3.

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http://dx.doi.org/10.15698/mic2019.08.687DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6685046PMC
July 2019

Physical Forces Modulate Oxidative Status and Stress Defense Meditated Metabolic Adaptation of Yeast Colonies: Spaceflight and Microgravity Simulations.

Microgravity Sci Technol 2018 29;30(3):195-208. Epub 2017 Dec 29.

3Space Policy Institute, Elliott School of International Affairs, George Washington University, Washington, DC 20052 USA.

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http://dx.doi.org/10.1007/s12217-017-9588-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6560652PMC
December 2017

Genome-Wide Screen Reveals Mutants of Are Methotrexate-Resistant.

G3 (Bethesda) 2017 04 3;7(4):1251-1257. Epub 2017 Apr 3.

Department of Pharmaceutical Sciences, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada

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http://dx.doi.org/10.1534/g3.116.038117DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5386873PMC
April 2017

Signaling pathways coordinating the alkaline pH response confer resistance to the hevein-type plant antimicrobial peptide Pn-AMP1 in Saccharomyces cerevisiae.

Planta 2016 Dec 10;244(6):1229-1240. Epub 2016 Aug 10.

Division of Science Education and Institute of Science Education, Chonbuk National University, Jeonju, 761-756, Republic of Korea.

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http://dx.doi.org/10.1007/s00425-016-2579-2DOI Listing
December 2016

Functional Profiling Using the Saccharomyces Genome Deletion Project Collections.

Cold Spring Harb Protoc 2016 09 1;2016(9). Epub 2016 Sep 1.

Department of Pharmaceutical Sciences, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada.

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http://dx.doi.org/10.1101/pdb.prot088039DOI Listing
September 2016

Identification of Chemical-Genetic Interactions via Parallel Analysis of Barcoded Yeast Strains.

Cold Spring Harb Protoc 2016 09 1;2016(9). Epub 2016 Sep 1.

Stanford Genome Technology Center, Department of Biochemistry, Stanford University, Palo Alto, California 94304;

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http://dx.doi.org/10.1101/pdb.prot088054DOI Listing
September 2016

Systematic Mapping of Chemical-Genetic Interactions in Saccharomyces cerevisiae.

Cold Spring Harb Protoc 2016 09 1;2016(9). Epub 2016 Sep 1.

Stanford Genome Technology Center, Department of Biochemistry, Stanford University, Palo Alto, California 94304;

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http://dx.doi.org/10.1101/pdb.top077701DOI Listing
September 2016

Functional Genomics Using the Saccharomyces cerevisiae Yeast Deletion Collections.

Cold Spring Harb Protoc 2016 09 1;2016(9). Epub 2016 Sep 1.

Department of Pharmaceutical Sciences, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada.

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http://dx.doi.org/10.1101/pdb.top080945DOI Listing
September 2016

Reverse Chemical Genetics: Comprehensive Fitness Profiling Reveals the Spectrum of Drug Target Interactions.

PLoS Genet 2016 09 2;12(9):e1006275. Epub 2016 Sep 2.

Department of Pharmaceutical Sciences, University of British Columbia, Vancouver, Canada.

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http://dx.doi.org/10.1371/journal.pgen.1006275DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5010250PMC
September 2016

Chromosome-wide histone deacetylation by sirtuins prevents hyperactivation of DNA damage-induced signaling upon replicative stress.

Nucleic Acids Res 2016 Apr 8;44(6):2706-26. Epub 2016 Jan 8.

Maisonneuve-Rosemont Hospital Research Center, 5415 Assomption boulevard, Montreal, H1T 2M4, Canada Department of Medicine, Université de Montréal, Montreal, H3T 1J4, Canada

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http://dx.doi.org/10.1093/nar/gkv1537DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4824096PMC
April 2016

A Signaling Lipid Associated with Alzheimer's Disease Promotes Mitochondrial Dysfunction.

Sci Rep 2016 Jan 13;6:19332. Epub 2016 Jan 13.

Ottawa Institute of Systems Biology, Department of Biochemistry, Microbiology, and Immunology, University of Ottawa, Ottawa, Ontario, KlH 8M5 Canada.

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http://dx.doi.org/10.1038/srep19332DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4725818PMC
January 2016

Genes required for survival in microgravity revealed by genome-wide yeast deletion collections cultured during spaceflight.

Biomed Res Int 2015 13;2015:976458. Epub 2015 Jan 13.

Durham VA Medical Center, Research & Development Service, Durham, NC 27705, USA ; Department of Veterans Affairs Office of Research and Development, Washington, DC 20420, USA ; Nephrology Division, Department of Internal Medicine, Duke University School of Medicine, Durham, NC 27705, USA ; Nephrology Section, Department of Internal Medicine, George Washington University School of Medicine, Washington, DC 20052, USA.

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http://dx.doi.org/10.1155/2015/976458DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4309212PMC
November 2015

An Updated Collection of Sequence Barcoded Temperature-Sensitive Alleles of Yeast Essential Genes.

G3 (Bethesda) 2015 Jul 14;5(9):1879-87. Epub 2015 Jul 14.

Terry Fox Laboratory, BC Cancer Research Centre, Vancouver, Canada Department of Medical Genetics, University of British Columbia, Vancouver V6T 1Z4, Canada

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http://dx.doi.org/10.1534/g3.115.019174DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4555224PMC
July 2015

The yeast deletion collection: a decade of functional genomics.

Genetics 2014 Jun 17;197(2):451-65. Epub 2014 Jun 17.

University of British Columbia, Vancouver, British Columbia, Canada V6T1Z3.

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http://genetics.org/content/197/2/451.full-text.pdf
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http://www.genetics.org/cgi/doi/10.1534/genetics.114.161620
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http://dx.doi.org/10.1534/genetics.114.161620DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4063906PMC
June 2014

A genome scale overexpression screen to reveal drug activity in human cells.

Genome Med 2014 29;6(4):32. Epub 2014 Apr 29.

Department of Molecular Genetics, University of Toronto, Toronto, M5S 3E1, Canada ; Banting and Best Department of Medical Research, University of Toronto, Toronto, M5S 3E1, Canada ; Terrence Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, 160 College Street, Toronto, Ontario M5S 3E1, Canada ; Donnelly Sequencing Center, University of Toronto, 160 College Street, Toronto, Ontario M5S 3E1, Canada ; Department of Pharmaceutical Sciences, University of British Columbia, 6619-2405 Wesbrook Mall, Vancouver, BC V6T 1Z3, Canada.

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http://dx.doi.org/10.1186/gm549DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4062067PMC
June 2014

Large-scale identification and analysis of suppressive drug interactions.

Chem Biol 2014 Apr 3;21(4):541-551. Epub 2014 Apr 3.

Donnelly Centre, University of Toronto, Toronto, ON M5S 3E1, Canada; Center for Cancer Systems Biology, Dana-Farber Cancer Institute, One Jimmy Fund Way, Boston, MA 02215, USA; Lunenfeld-Tanenbaum Research Institute, Mt. Sinai Hospital, Toronto, ON M5G 1X5, Canada; Departments of Molecular Genetics and Computer Science, University of Toronto, Toronto, ON M5S 3E1, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.chembiol.2014.02.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4281482PMC
April 2014

PITPs as targets for selectively interfering with phosphoinositide signaling in cells.

Nat Chem Biol 2014 Jan 24;10(1):76-84. Epub 2013 Nov 24.

1] Department of Molecular and Cellular Medicine, Texas A&M University College Station, Texas, USA. [2] Department of Biochemistry and Biophysics, Texas A&M University College Station, Texas, USA. [3] Department of Chemistry, Texas A&M University College Station, Texas, USA. [4] Department of Cell and Developmental Biology, Lineberger Comprehensive Cancer Center, University of North Carolina School of Medicine, Chapel Hill, North Carolina, USA.

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http://dx.doi.org/10.1038/nchembio.1389DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4059020PMC
January 2014

A novel small molecule methyltransferase is important for virulence in Candida albicans.

ACS Chem Biol 2013 Dec 16;8(12):2785-93. Epub 2013 Oct 16.

Department of Molecular Genetics, Terrence Donnelly Centre for Cellular and Biomolecular Research, University of Toronto , 160 College St., Toronto, M5S 3E1, Canada.

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http://dx.doi.org/10.1021/cb400607hDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3928151PMC
December 2013

Barcode sequencing for understanding drug-gene interactions.

Methods Mol Biol 2012 ;910:55-69

Donnelly Centre, University of Toronto, Toronto, ON, Canada.

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http://dx.doi.org/10.1007/978-1-61779-965-5_4DOI Listing
September 2013

Miniature short hairpin RNA screens to characterize antiproliferative drugs.

G3 (Bethesda) 2013 Aug 7;3(8):1375-87. Epub 2013 Aug 7.

Department of Molecular Genetics, University of Toronto, Toronto, Ontario M5S 3E1, Canada.

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http://dx.doi.org/10.1534/g3.113.006437DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3737177PMC
August 2013

A high-throughput yeast assay identifies synergistic drug combinations.

Assay Drug Dev Technol 2013 Jun;11(5):299-307

Donnelly Centre, University of Toronto, Toronto, Canada.

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http://dx.doi.org/10.1089/adt.2012.503DOI Listing
June 2013

DNA-damaging agents in cancer chemotherapy: serendipity and chemical biology.

Chem Biol 2013 May;20(5):648-59

Department of Molecular Genetics and the Donnelly Centre, University of Toronto, Toronto, ON M5S 3E1, Canada.

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http://dx.doi.org/10.1016/j.chembiol.2013.04.007DOI Listing
May 2013

Chromatin is an ancient innovation conserved between Archaea and Eukarya.

Elife 2012 Dec 13;1:e00078. Epub 2012 Dec 13.

Department of Molecular Genetics , University of Toronto , Toronto , Canada ; Donnelly Centre , University of Toronto , Toronto , Canada.

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http://dx.doi.org/10.7554/eLife.00078DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3510453PMC
December 2012

Comparative chemogenomics to examine the mechanism of action of dna-targeted platinum-acridine anticancer agents.

ACS Chem Biol 2012 Nov 5;7(11):1892-901. Epub 2012 Sep 5.

Department of Molecular Genetics and the Donnelly Centre, University of Toronto, Toronto, ON, M5S3E1 Canada.

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http://dx.doi.org/10.1021/cb300320dDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3500413PMC
November 2012

A novel calcineurin-independent activity of cyclosporin A in Saccharomyces cerevisiae.

Mol Biosyst 2012 Oct;8(10):2575-84

Department of Molecular Genetics, University of Toronto, 1 King's College Circle, Medical Sciences Building, Room 4368, Toronto, Ontario M5S 1A8, Canada.

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http://xlink.rsc.org/?DOI=c2mb25107h
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http://dx.doi.org/10.1039/c2mb25107hDOI Listing
October 2012

An algorithm for chemical genomic profiling that minimizes batch effects: bucket evaluations.

BMC Bioinformatics 2012 Sep 25;13:245. Epub 2012 Sep 25.

Department of Cell and Systems Biology and the Donnelly Centre, University of Toronto, Toronto, ON, Canada.

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http://dx.doi.org/10.1186/1471-2105-13-245DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3780717PMC
September 2012

Genome-wide analysis of intracellular pH reveals quantitative control of cell division rate by pH(c) in Saccharomyces cerevisiae.

Genome Biol 2012 Sep 10;13(9):R80. Epub 2012 Sep 10.

Molecular Biology and Microbial Food Safety, Swammerdam Institute for Life Sciences, University of Amsterdam, Science Park 904, 1098 XH Amsterdam, the Netherlands.

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http://genomebiology.biomedcentral.com/articles/10.1186/gb-2
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http://dx.doi.org/10.1186/gb-2012-13-9-r80DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3506951PMC
September 2012

Displaying chemical information on a biological network using Cytoscape.

Methods Mol Biol 2011 ;781:363-76

Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada.

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http://dx.doi.org/10.1007/978-1-61779-276-2_18DOI Listing
January 2012

Bugs, drugs and chemical genomics.

Nat Chem Biol 2011 Dec 15;8(1):46-56. Epub 2011 Dec 15.

Department of Infectious Disease, Merck, Kenilworth, New Jersey, USA.

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http://dx.doi.org/10.1038/nchembio.744DOI Listing
December 2011

Curcumin inhibits growth of Saccharomyces cerevisiae through iron chelation.

Eukaryot Cell 2011 Nov 9;10(11):1574-81. Epub 2011 Sep 9.

Department of Biology, Stanford University, Stanford, CA 94305-5020, USA.

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http://dx.doi.org/10.1128/EC.05163-11DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3209049PMC
November 2011

Dafadine inhibits DAF-9 to promote dauer formation and longevity of Caenorhabditis elegans.

Nat Chem Biol 2011 Nov 6;7(12):891-3. Epub 2011 Nov 6.

Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1038/nchembio.698DOI Listing
November 2011

Systematic exploration of synergistic drug pairs.

Mol Syst Biol 2011 Nov 8;7:544. Epub 2011 Nov 8.

Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1038/msb.2011.71DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3261710PMC
November 2011

Multiple means to the same end: the genetic basis of acquired stress resistance in yeast.

PLoS Genet 2011 Nov 10;7(11):e1002353. Epub 2011 Nov 10.

Laboratory of Genetics, University of Wisconsin-Madison, Madison, Wisconsin, United States of America.

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http://dx.doi.org/10.1371/journal.pgen.1002353DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3213159PMC
November 2011

New azole antifungal agents with novel modes of action: synthesis and biological studies of new tridentate ligands based on pyrazole and triazole.

Eur J Med Chem 2011 Sep 17;46(9):4117-24. Epub 2011 Jun 17.

Laboratoire de Chimie Appliquée et Environnement, Département de Chimie, Faculté des Sciences, Université Mohamed Premier, BP 524, 60000 Oujda, Morocco.

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http://linkinghub.elsevier.com/retrieve/pii/S022352341100488
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http://dx.doi.org/10.1016/j.ejmech.2011.06.012DOI Listing
September 2011

Competitive genomic screens of barcoded yeast libraries.

J Vis Exp 2011 Aug 11(54). Epub 2011 Aug 11.

Banting and Best Department of Medical Research and Department of Molecular Genetics, University of Toronto, Canada.

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http://www.jove.com/details.php?id=2864
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http://dx.doi.org/10.3791/2864DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3211125PMC
August 2011

The synthetic genetic interaction network reveals small molecules that target specific pathways in Sacchromyces cerevisiae.

Mol Biosyst 2011 Jun 12;7(6):2019-30. Epub 2011 Apr 12.

Department of Chemistry and Biochemistry, University of California Santa Cruz, 1156 High St., Santa Cruz, CA 95064, USA.

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http://dx.doi.org/10.1039/c0mb00298dDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4653045PMC
June 2011

Exploring gene function and drug action using chemogenomic dosage assays.

Methods Enzymol 2010 1;470:233-55. Epub 2010 Mar 1.

Department of Pharmaceutical Sciences, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1016/S0076-6879(10)70010-0DOI Listing
January 2011

Gene annotation and drug target discovery in Candida albicans with a tagged transposon mutant collection.

PLoS Pathog 2010 Oct 7;6(10):e1001140. Epub 2010 Oct 7.

Department of Genetics, Stanford University, Palo Alto, California, United States of America.

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http://dx.doi.org/10.1371/journal.ppat.1001140DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2951378PMC
October 2010

Systematic analysis of genome-wide fitness data in yeast reveals novel gene function and drug action.

Genome Biol 2010 12;11(3):R30. Epub 2010 Mar 12.

Biomedical Informatics, 251 Campus Drive, MSOB, Stanford University, Stanford, CA 94305, USA.

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http://dx.doi.org/10.1186/gb-2010-11-3-r30DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2864570PMC
September 2010

A universal TagModule collection for parallel genetic analysis of microorganisms.

Nucleic Acids Res 2010 Aug 21;38(14):e146. Epub 2010 May 21.

Department of Genetics, Stanford University, Palo Alto, CA 94305, USA.

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http://dx.doi.org/10.1093/nar/gkq419DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2919733PMC
August 2010

A survey of yeast genomic assays for drug and target discovery.

Pharmacol Ther 2010 Aug 28;127(2):156-64. Epub 2010 May 28.

Department of Molecular Genetics, University of Toronto, 1 King's College Circle, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1016/j.pharmthera.2010.04.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2923554PMC
August 2010

Highly-multiplexed barcode sequencing: an efficient method for parallel analysis of pooled samples.

Nucleic Acids Res 2010 Jul 11;38(13):e142. Epub 2010 May 11.

Department of Molecular Genetics, University of Toronto, 1 King's College Circle, Toronto, Ontario M5S 1A8, Canada.

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http://dx.doi.org/10.1093/nar/gkq368DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2910071PMC
July 2010

A predictive model for drug bioaccumulation and bioactivity in Caenorhabditis elegans.

Nat Chem Biol 2010 Jul 30;6(7):549-57. Epub 2010 May 30.

Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1038/nchembio.380DOI Listing
July 2010

Genome-wide screen in Saccharomyces cerevisiae identifies vacuolar protein sorting, autophagy, biosynthetic, and tRNA methylation genes involved in life span regulation.

PLoS Genet 2010 Jul 15;6(7):e1001024. Epub 2010 Jul 15.

Andrus Gerontology Center and Department of Biological Sciences, University of Southern California, Los Angeles, California, United States of America.

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http://dx.doi.org/10.1371/journal.pgen.1001024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2904796PMC
July 2010

Genotype to phenotype: a complex problem.

Science 2010 Apr;328(5977):469

Computer Science and Artificial Intelligence Laboratory, Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology (MIT), Cambridge, MA 02139, USA.

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http://dx.doi.org/10.1126/science.1189015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4412269PMC
April 2010

Quantitative phenotyping via deep barcode sequencing.

Genome Res 2009 Oct 21;19(10):1836-42. Epub 2009 Jul 21.

Department of Molecular Genetics, University of Toronto, Ontario, Canada.

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http://dx.doi.org/10.1101/gr.093955.109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2765281PMC
October 2009

A comparative analysis of DNA barcode microarray feature size.

BMC Genomics 2009 Oct 13;10:471. Epub 2009 Oct 13.

Department of Molecular Genetics, University of Toronto, 1 King's College Circle, Toronto, Ontario M5S 1A8, Canada.

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http://dx.doi.org/10.1186/1471-2164-10-471DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2765990PMC
October 2009

Chemogenomic approaches to elucidation of gene function and genetic pathways.

Methods Mol Biol 2009 ;548:115-43

Department of Pharmaceutical Sciences, University of Toronto, Toronto, ON, Canada M5S 3E1.

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http://dx.doi.org/10.1007/978-1-59745-540-4_7DOI Listing
July 2009

Precise gene-dose alleles for chemical genetics.

Genetics 2009 Jun 30;182(2):623-6. Epub 2009 Mar 30.

Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Ontario M5S 3E1, Canada.

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http://dx.doi.org/10.1534/genetics.109.103036DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2691769PMC
June 2009

Knocking sense into regulatory pathways.

Nat Biotechnol 2009 Feb;27(2):149-50

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http://dx.doi.org/10.1038/nbt0209-149DOI Listing
February 2009

Combination chemical genetics.

Nat Chem Biol 2008 Nov;4(11):674-81

CombinatoRx Incorporated, 245 First Street, Cambridge, Massachusetts 02142, USA.

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http://www.nature.com/articles/nchembio.120
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http://dx.doi.org/10.1038/nchembio.120DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2712875PMC
November 2008

Yeast chemical genomics and drug discovery: an update.

Trends Pharmacol Sci 2008 Oct 26;29(10):499-504. Epub 2008 Aug 26.

Department of Genetics, Stanford University, Palo Alto, CA 94305, USA.

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http://dx.doi.org/10.1016/j.tips.2008.07.006DOI Listing
October 2008

An integrated platform of genomic assays reveals small-molecule bioactivities.

Nat Chem Biol 2008 Aug 11;4(8):498-506. Epub 2008 Jul 11.

Department of Genetics, Stanford University, Mail Stop-5120, Palo Alto, California 94305, USA.

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http://dx.doi.org/10.1038/nchembio.100DOI Listing
August 2008

Yeast Barcoders: a chemogenomic application of a universal donor-strain collection carrying bar-code identifiers.

Nat Methods 2008 Aug 11;5(8):719-25. Epub 2008 Jul 11.

Terrence Donnelly Center for Cellular and Biomolecular Research, University of Toronto, 160 College Street, Toronto, Ontario M5S 3E1, Canada.

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http://www.nature.com/articles/nmeth.1231
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http://dx.doi.org/10.1038/nmeth.1231DOI Listing
August 2008

Off-target effects of psychoactive drugs revealed by genome-wide assays in yeast.

PLoS Genet 2008 Aug 8;4(8):e1000151. Epub 2008 Aug 8.

Department of Pharmaceutical Sciences, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1371/journal.pgen.1000151DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2483942PMC
August 2008

The extensive and condition-dependent nature of epistasis among whole-genome duplicates in yeast.

Genome Res 2008 Jul 7;18(7):1092-9. Epub 2008 May 7.

Banting and Best Department of Medical Research, Terrence Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Ontario M5S 3E1, Canada.

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http://www.genome.org/cgi/doi/10.1101/gr.076174.108
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http://dx.doi.org/10.1101/gr.076174.108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2493398PMC
July 2008

Chemical-genetic approaches for exploring the mode of action of natural products.

Prog Drug Res 2008 ;66:237, 239-71

Banting and Best Department of Medical Research and Department of Medical Genetics and Microbiology, Terrence Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, 160 College Street, Toronto, Canada.

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http://dx.doi.org/10.1007/978-3-7643-8595-8_5DOI Listing
May 2008

Defining genetic interaction.

Proc Natl Acad Sci U S A 2008 Mar 27;105(9):3461-6. Epub 2008 Feb 27.

Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, 250 Longwood Avenue, Boston, MA 02115, USA.

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http://www.pnas.org/cgi/doi/10.1073/pnas.0712255105
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http://dx.doi.org/10.1073/pnas.0712255105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2265146PMC
March 2008

Genome-wide analysis of barcoded Saccharomyces cerevisiae gene-deletion mutants in pooled cultures.

Nat Protoc 2007 ;2(11):2958-74

Department of Genetics, Stanford Genome Technology Center, 855 S California Ave, Palo Alto, CA 94304, USA.

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http://dx.doi.org/10.1038/nprot.2007.427DOI Listing
February 2008