Publications


Structural determination of lipid antigens captured at the CD1d-T-cell receptor interface.
Proc Natl Acad Sci U S A 2017 Jul 17. Epub 2017 Jul 17.
Department of Medicine, Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115;

Fluorescent mannosides serve as acceptor substrates for glycosyltransferase and sugar-1-phosphate transferase activities in Euglena gracilis membranes.
Carbohydr Res 2017 Jan 30;438:26-38. Epub 2016 Nov 30.
Department of Biological Chemistry, John Innes Centre, Norwich Research Park, Norwich NR4 7UH, UK. Electronic address:



Identification of a Desaturase Involved in Mycolic Acid Biosynthesis in Mycobacterium smegmatis.
PLoS One 2016 14;11(10):e0164253. Epub 2016 Oct 14.
School of Biosciences and Institute of Microbiology and Infection, University of Birmingham, Edgbaston, Birmingham, B15 2TT, United Kingdom.


The actin cytoskeleton modulates the activation of iNKT cells by segregating CD1d nanoclusters on antigen-presenting cells.
Proc Natl Acad Sci U S A 2016 Feb 21;113(6):E772-81. Epub 2016 Jan 21.
ICFO-Institut de Ciencies Fotoniques, The Barcelona Institute of Science and Technology, 08860 Barcelona, Spain; Institució Catalana de Recerca i Estudis Avançats (ICREA), 08010 Barcelona, Spain

Atypical natural killer T-cell receptor recognition of CD1d-lipid antigens.
Nat Commun 2016 Feb 15;7:10570. Epub 2016 Feb 15.
Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, Victoria 3000, Australia.

"Endocytic pH regulates cell surface localization of glycolipid antigen loaded CD1d complexes".
Chem Phys Lipids 2016 Jan 6;194:49-57. Epub 2015 Nov 6.
Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA; Department of Medicine, Albert Einstein College of Medicine, Bronx, NY 10461, USA. Electronic address:

Human autoreactive T cells recognize CD1b and phospholipids.
Proc Natl Acad Sci U S A 2016 Jan 30;113(2):380-5. Epub 2015 Nov 30.
Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115;



Antigen Specificity of Type I NKT Cells Is Governed by TCR β-Chain Diversity.
J Immunol 2015 Nov 30;195(10):4604-14. Epub 2015 Sep 30.
Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne, Parkville, Victoria 3010, Australia; Australian Research Council Centre of Excellence in Advanced Molecular Imaging, University of Melbourne, Parkville, Victoria 3010, Australia;

Endocytic pH regulates cell surface localization of glycolipid antigen loaded CD1d complexes.
Chem Phys Lipids 2015 Oct 22;191:75-83. Epub 2015 Aug 22.
Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA; Department of Medicine, Albert Einstein College of Medicine, Bronx, NY 10461, USA. Electronic address:

Identification of a Potent Microbial Lipid Antigen for Diverse NKT Cells.
J Immunol 2015 Sep 7;195(6):2540-51. Epub 2015 Aug 7.
Division of Rheumatology, Immunology, and Allergy, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115;

A Novel Glycolipid Antigen for NKT Cells That Preferentially Induces IFN-γ Production.
J Immunol 2015 Aug 15;195(3):924-33. Epub 2015 Jun 15.
Division of Developmental Immunology, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037; Division of Biological Sciences, University of California, San Diego, La Jolla, CA 92037;

A Subset of CD8αβ+ Invariant NKT Cells in a Humanized Mouse Model.
J Immunol 2015 Aug 8;195(4):1459-69. Epub 2015 Jul 8.
Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033;

Morphological and biomolecular evidence for tuberculosis in 8th century AD skeletons from Bélmegyer-Csömöki domb, Hungary.
Tuberculosis (Edinb) 2015 Jun 13;95 Suppl 1:S35-41. Epub 2015 Feb 13.
Department of Biological Anthropology, University of Szeged, Szeged, Hungary. Electronic address:

Human tuberculosis predates domestication in ancient Syria.
Tuberculosis (Edinb) 2015 Jun 26;95 Suppl 1:S4-S12. Epub 2015 Feb 26.
Laboratoire d'Anthropologie biologique Paul Broca, Ecole Pratique des Hautes Etudes, Paris, France; De la Préhistoire à l'Actuel: Culture, Environnement, Anthropologie (PACEA, UMR 5199, CNRS, Université de Bordeaux, Ministère de la Culture et de la Communication), Allée Geoffroy St Hilaire, CS 50023, 33615 Pessac Cedex, France; Department of Anthropology, University of Western Ontario, London, Canada. Electronic address:

Osteological, biomolecular and geochemical examination of an early anglo-saxon case of lepromatous leprosy.
PLoS One 2015 13;10(5):e0124282. Epub 2015 May 13.
Department of Microbial and Cellular Sciences, School of Biosciences and Medicine, University of Surrey, Guildford, GU2 7TE, United Kingdom.

A migration-driven model for the historical spread of leprosy in medieval Eastern and Central Europe.
Infect Genet Evol 2015 Apr 11;31:250-6. Epub 2015 Feb 11.
Centre for Clinical Microbiology, Division of Infection and Immunity, University College London, UK; Department of Anatomy and Anthropology Sackler Medical School, Tel Aviv University, Israel.

In contrast to other species, α-Galactosylceramide (α-GalCer) is not an immunostimulatory NKT cell agonist in horses.
Dev Comp Immunol 2015 Mar 10;49(1):49-58. Epub 2014 Nov 10.
Department of Veterinary Microbiology and Pathology, Washington State University, College of Veterinary Medicine, P.O. Box 647040, Pullman, WA 99164-7040, USA. Electronic address:

Mycobacterial dihydrofolate reductase inhibitors identified using chemogenomic methods and in vitro validation.
PLoS One 2015 23;10(3):e0121492. Epub 2015 Mar 23.
Institute of Microbiology and Infection (IMI), School of Biosciences, University of Birmingham, Edgbaston, Birmingham, United Kingdom.

Gal-3 regulates the capacity of dendritic cells to promote NKT-cell-induced liver injury.
Eur J Immunol 2015 Feb 27;45(2):531-43. Epub 2014 Nov 27.
Centre for Molecular Medicine and Stem Cell Research, Faculty of Medical Sciences, University of Kragujevac, Kragujevac, Serbia.

Cytotoxic mediators in paradoxical HIV-tuberculosis immune reconstitution inflammatory syndrome.
J Immunol 2015 Feb 14;194(4):1748-54. Epub 2015 Jan 14.
Clinical Infectious Diseases Research Initiative, University of Cape Town, Cape Town, 7925 South Africa; Department of Medicine, University of Cape Town, Cape Town, 7925 South Africa; Medical Research Council National Institute for Medical Research, London NW7 1AA, United Kingdom; Division of Medicine, Imperial College London, London W2 1PG, United Kingdom;

The C-type lectin receptor CLECSF8/CLEC4D is a key component of anti-mycobacterial immunity.
Cell Host Microbe 2015 Feb;17(2):252-9
Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD, UK; Division of Immunology, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, 792 Cape Town, South Africa. Electronic address:

Essential role for autophagy during invariant NKT cell development.
Proc Natl Acad Sci U S A 2014 Dec 15;111(52):E5678-87. Epub 2014 Dec 15.
Medical Research Council Human Immunology Unit, Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford, Headington, Oxford OX3 9DS, United Kingdom;

Selectfluor and NFSI exo-glycal fluorination strategies applied to the enhancement of the binding affinity of galactofuranosyltransferase GlfT2 inhibitors.
Chemistry 2014 Nov 24;20(46):15208-15. Epub 2014 Sep 24.
University of Namur (UNamur), Département de Chimie, Laboratoire de Chimie Bio-Organique rue de Bruxelles 61, B-5000 Namur (Belgium), Fax: (+32) 81-72-45-17.


Activation of iNKT cells by a distinct constituent of the endogenous glucosylceramide fraction.
Proc Natl Acad Sci U S A 2014 Sep 2;111(37):13433-8. Epub 2014 Sep 2.
Department of Medicine, Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115;


Benzothiazinones mediate killing of Corynebacterineae by blocking decaprenyl phosphate recycling involved in cell wall biosynthesis.
J Biol Chem 2014 Feb 20;289(9):6177-87. Epub 2014 Jan 20.
From the School of Biosciences, Institute of Microbiology and Infection, University of Birmingham, Edgbaston, Birmingham B15 2TT, United Kingdom and.


A single subset of dendritic cells controls the cytokine bias of natural killer T cell responses to diverse glycolipid antigens.
Immunity 2014 Jan 9;40(1):105-16. Epub 2014 Jan 9.
Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA; Department of Medicine, Albert Einstein College of Medicine, Bronx, NY 10461, USA. Electronic address:

Mannan core branching of lipo(arabino)mannan is required for mycobacterial virulence in the context of innate immunity.
Cell Microbiol 2013 Dec 22;15(12):2093-108. Epub 2013 Aug 22.
Department of Medical Microbiology and Infection Control, VU University Medical Center, van der Boechorststraat 7, 1081 BT, Amsterdam, The Netherlands.

Saposins modulate human invariant Natural Killer T cells self-reactivity and facilitate lipid exchange with CD1d molecules during antigen presentation.
Proc Natl Acad Sci U S A 2013 Dec 18;110(49):E4753-61. Epub 2013 Nov 18.
Medical Research Council Human Immunology Unit, Radcliffe Department of Medicine, Medical Research Council Weatherall Institute of Molecular Medicine, University of Oxford, Headington, Oxford OX3 9DS, United Kingdom.

Osteological and biomolecular evidence of a 7000-year-old case of hypertrophic pulmonary osteopathy secondary to tuberculosis from neolithic hungary.
PLoS One 2013 30;8(10):e78252. Epub 2013 Oct 30.
Archaeology, University of Edinburgh, Edinburgh, Scotland, United Kingdom ; Department of Biological Anthropology, University of Szeged, Szeged, Hungary.

Gram-positive bacterial lipoglycans based on a glycosylated diacylglycerol lipid anchor are microbe-associated molecular patterns recognized by TLR2.
PLoS One 2013 21;8(11):e81593. Epub 2013 Nov 21.
CNRS; IPBS (Institut de Pharmacologie et de Biologie Structurale); 205 route de Narbonne, F-31077 Toulouse, France ; Université de Toulouse; UPS; IPBS; F-31077 Toulouse, France.



Cord factor and peptidoglycan recapitulate the Th17-promoting adjuvant activity of mycobacteria through mincle/CARD9 signaling and the inflammasome.
J Immunol 2013 Jun 29;190(11):5722-30. Epub 2013 Apr 29.
Immunobiology Section, Laboratory of Parasitic Diseases, National Institute for Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

Detection and strain typing of ancient Mycobacterium leprae from a medieval leprosy hospital.
PLoS One 2013 30;8(4):e62406. Epub 2013 Apr 30.
Department of Microbial and Cellular Science, Faculty of Health and Medical Sciences, University of Surrey, Guildford, Surrey, United Kingdom.



Recognition of microbial and mammalian phospholipid antigens by NKT cells with diverse TCRs.
Proc Natl Acad Sci U S A 2013 Jan 10;110(5):1827-32. Epub 2013 Jan 10.
Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.

Human and mouse type I natural killer T cell antigen receptors exhibit different fine specificities for CD1d-antigen complex.
J Biol Chem 2012 Nov 20;287(46):39139-48. Epub 2012 Sep 20.
Australian Research Council (ARC) Centre of Excellence in Structural and Functional Microbial Genomics, Department of Biochemistry and Molecular Biology, School of Biomedical Sciences, Monash University, Clayton, Victoria 3800, Australia.


SAP expression in invariant NKT cells is required for cognate help to support B-cell responses.
Blood 2012 Jul 21;120(1):122-9. Epub 2012 May 21.
Division of Immunology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA.

Unexpected link between lipooligosaccharide biosynthesis and surface protein release in Mycobacterium marinum.
J Biol Chem 2012 Jun 13;287(24):20417-29. Epub 2012 Apr 13.
Department of Medical Microbiology and Infection Control, VU University Medical Center, 1081 HV Amsterdam, The Netherlands.


Saposins utilize two strategies for lipid transfer and CD1 antigen presentation.
Proc Natl Acad Sci U S A 2012 Mar 13;109(12):4357-64. Epub 2012 Feb 13.
Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.

Innate recognition of cell wall β-glucans drives invariant natural killer T cell responses against fungi.
Cell Host Microbe 2011 Nov;10(5):437-50
Department of Medicine, Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.

OF