Guoxun Chen

Guoxun Chen

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Guoxun Chen

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Vitamin A Status Affects Weight Gain and Hepatic Glucose Metabolism in Rats Fed a High-Fat Diet.

Biochem Cell Biol 2019 Feb 25. Epub 2019 Feb 25.

The University of Tennessee at Knoxville, Nutrition , Room 229, Jessie Harris Building , 1215 West Cumberland Avenue , Knoxville, Tennessee, United States , 37996 ;

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http://dx.doi.org/10.1139/bcb-2018-0284DOI Listing
February 2019

Dietary DHA/EPA Ratio Changes Fatty Acid Composition and Attenuates Diet-Induced Accumulation of Lipid in the Liver of ApoE Mice.

Oxid Med Cell Longev 2018 14;2018:6256802. Epub 2018 Nov 14.

Key Laboratory for Deep Processing of Major Grain and Oil, Ministry of Education, Wuhan 430023, China.

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https://www.hindawi.com/journals/omcl/2018/6256802/
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http://dx.doi.org/10.1155/2018/6256802DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6261399PMC
January 2019

Eating Frequency Is Not Associated with Obesity in Chinese Adults.

Int J Environ Res Public Health 2018 11 15;15(11). Epub 2018 Nov 15.

Department of Family & Community Medicine, Wake Forest School of Medicine, Wake Forest Baptist Medical Center, Medical Center Boulevard, Winston-Salem, NC 27157, USA.

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http://www.mdpi.com/1660-4601/15/11/2561
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http://dx.doi.org/10.3390/ijerph15112561DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6266818PMC
November 2018

Long sleep duration predicts a higher risk of obesity in adults: a meta-analysis of prospective cohort studies.

J Public Health (Oxf) 2018 Aug 13. Epub 2018 Aug 13.

Department of Family & Community Medicine, Wake Forest School of Medicine, Medical Center Boulevard, Winston-Salem, NC, USA.

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http://dx.doi.org/10.1093/pubmed/fdy135DOI Listing
August 2018

The Impact of Egg Nutrient Composition and Its Consumption on Cholesterol Homeostasis.

Cholesterol 2018 23;2018:6303810. Epub 2018 Aug 23.

Department of Nutrition, University of Tennessee at Knoxville, Knoxville, Tennessee, USA.

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http://dx.doi.org/10.1155/2018/6303810DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6126094PMC
August 2018

Body Weight Misperception and Its Association with Unhealthy Eating Behaviors among Adolescents in China.

Int J Environ Res Public Health 2018 05 8;15(5). Epub 2018 May 8.

Department of Family & Community Medicine, Wake Forest School of Medicine, Medical Center Boulevard, Winston-Salem, NC 27157, USA.

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http://dx.doi.org/10.3390/ijerph15050936DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5981975PMC
May 2018

Genomics Approach of the Natural Product Pharmacology for High Impact Diseases.

Int J Genomics 2018 8;2018:9468912. Epub 2018 Apr 8.

Department of Nutrition, University of Tennessee, Knoxville, TN, USA.

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http://dx.doi.org/10.1155/2018/9468912DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5911340PMC
April 2018

Fatty acids modulate the expression levels of key proteins for cholesterol absorption in Caco-2 monolayer.

Lipids Health Dis 2018 Feb 20;17(1):32. Epub 2018 Feb 20.

National Research and Development Center for Egg Processing, College of Food Science and Technology, Huazhong Agricultural University, 430070, Wuhan, Hubei, People's Republic of China.

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http://dx.doi.org/10.1186/s12944-018-0675-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5819267PMC
February 2018

Egg-Yolk Sphingomyelin and Phosphatidylcholine Attenuate Cholesterol Absorption in Caco-2 Cells.

Lipids 2018 02 22;53(2):217-233. Epub 2018 Mar 22.

National Research and Development Center for Egg Processing, College of Food Science and Technology, Huazhong Agricultural University, Wuhan, 430070, China.

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http://dx.doi.org/10.1002/lipd.12018DOI Listing
February 2018

The Effect of Vitamin A on Fracture Risk: A Meta-Analysis of Cohort Studies.

Int J Environ Res Public Health 2017 09 10;14(9). Epub 2017 Sep 10.

Department of Nutrition, The University of Tennessee, Knoxville, TN 37996, USA.

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http://dx.doi.org/10.3390/ijerph14091043DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5615580PMC
September 2017

Vitamin A status affects the plasma parameters and regulation of hepatic genes in streptozotocin-induced diabetic rats.

Biochimie 2017 Jun 24;137:1-11. Epub 2017 Feb 24.

Department of Nutrition, University of Tennessee at Knoxville, Knoxville, TN, USA. Electronic address:

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http://dx.doi.org/10.1016/j.biochi.2017.02.012DOI Listing
June 2017

Associations among Screen Time and Unhealthy Behaviors, Academic Performance, and Well-Being in Chinese Adolescents.

Int J Environ Res Public Health 2017 06 4;14(6). Epub 2017 Jun 4.

Wake Forest Baptist Medical Center, Department of Family & Community Medicine, Wake Forest School of Medicine, Medical Center Boulevard, Winston-Salem, NC 27157, USA.

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http://dx.doi.org/10.3390/ijerph14060596DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5486282PMC
June 2017

Danshen (Salvia miltiorrhiza Bunge): A Prospective Healing Sage for Cardiovascular Diseases.

Curr Pharm Des 2017 ;23(34):5125-5135

Department of Nutrition, University of Tennessee at Knoxville, Knoxville, 37996, United States.

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http://dx.doi.org/10.2174/1381612823666170822101112DOI Listing
January 2017

The link between Hepatic Vitamin A Metabolism and Nonalcoholic Fatty Liver Disease.

Authors:
Guoxun Chen

Curr Drug Targets 2015 ;16(12):1281-92

229 Jessie Harris Building, 1215 West Cumberland Avenue, Knoxville, Tennessee 37996, USA.

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August 2016

Roles of Vitamin A Metabolism in the Development of Hepatic Insulin Resistance.

Authors:
Guoxun Chen

ISRN Hepatol 2013 30;2013:534972. Epub 2013 Sep 30.

Department of Nutrition, University of Tennessee at Knoxville, Knoxville, TN 37996, USA.

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http://dx.doi.org/10.1155/2013/534972DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4890907PMC
June 2016

Gentiopicroside and sweroside from Veratrilla baillonii Franch. induce phosphorylation of Akt and suppress Pck1 expression in hepatoma cells.

Biochem Cell Biol 2016 06 18;94(3):270-8. Epub 2016 Feb 18.

b Department of Nutrition, University of Tennessee at Knoxville, 229 Jessie Harris Building, 1215 West Cumberland Avenue, Knoxville, TN 37996, USA.

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http://dx.doi.org/10.1139/bcb-2015-0173DOI Listing
June 2016

Higher protein kinase C ζ in fatty rat liver and its effect on insulin actions in primary hepatocytes.

PLoS One 2015 30;10(3):e0121890. Epub 2015 Mar 30.

Department of Nutrition, University of Tennessee at Knoxville, Knoxville, Tennessee, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0121890PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4379029PMC
April 2016

Vitamin A status and its metabolism contribute to the regulation of hepatic genes during the cycle of fasting and refeeding in rats.

J Nutr Biochem 2016 Apr 11;30:33-43. Epub 2015 Dec 11.

Department of Nutrition, University of Tennessee at Knoxville, Knoxville, TN, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jnutbio.2015.11.012DOI Listing
April 2016

Eating Frequency, Food Intake, and Weight: A Systematic Review of Human and Animal Experimental Studies.

Front Nutr 2015 18;2:38. Epub 2015 Dec 18.

Department of Nutrition, University of Tennessee , Knoxville, TN , USA.

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http://dx.doi.org/10.3389/fnut.2015.00038DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4683169PMC
January 2016

Transcriptional Factors Mediating Retinoic Acid Signals in the Control of Energy Metabolism.

Int J Mol Sci 2015 Jun 23;16(6):14210-44. Epub 2015 Jun 23.

Department of Nutrition, University of Tennessee at Knoxville, 1215 West Cumberland Avenue, Knoxville, TN 37996, USA.

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http://dx.doi.org/10.3390/ijms160614210DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4490549PMC
June 2015

Vitamin A and feeding statuses modulate the insulin-regulated gene expression in Zucker lean and fatty primary rat hepatocytes.

PLoS One 2014 8;9(8):e100868. Epub 2014 Aug 8.

Department of Nutrition, University of Tennessee at Knoxville, Knoxville, Tennessee, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0100868PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4126667PMC
April 2015

Effects of individual and multiple fatty acids (palmitate, oleate and docosahaexenoic acid) on cell viability and lipid metabolism in LO2 human liver cells.

Mol Med Rep 2014 Dec 18;10(6):3254-60. Epub 2014 Sep 18.

Department of Nutrition, The University of Tennessee at Knoxville, Knoxville, TN 37996, USA.

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http://dx.doi.org/10.3892/mmr.2014.2579DOI Listing
December 2014

A RARE of hepatic Gck promoter interacts with RARα, HNF4α and COUP-TFII that affect retinoic acid- and insulin-induced Gck expression.

J Nutr Biochem 2014 Sep 22;25(9):964-76. Epub 2014 May 22.

Department of Nutrition, University of Tennessee at Knoxville, Knoxville, TN 37996, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jnutbio.2014.04.009DOI Listing
September 2014

Factors affecting insulin-regulated hepatic gene expression.

Prog Mol Biol Transl Sci 2014 ;121:165-215

Department of Nutrition, University of Tennessee at Knoxville, Knoxville, Tennessee, USA.

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http://dx.doi.org/10.1016/B978-0-12-800101-1.00006-5DOI Listing
July 2014

The Roles of Vitamin A in the Regulation of Carbohydrate, Lipid, and Protein Metabolism.

J Clin Med 2014 May 7;3(2):453-79. Epub 2014 May 7.

Department of Nutrition, University of Tennessee at Knoxville, Knoxville, TN 37996, USA.

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http://dx.doi.org/10.3390/jcm3020453DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4449691PMC
May 2014

Zyflamend, a polyherbal mixture, down regulates class I and class II histone deacetylases and increases p21 levels in castrate-resistant prostate cancer cells.

BMC Complement Altern Med 2014 Feb 21;14:68. Epub 2014 Feb 21.

Department of Nutrition, University of Tennessee, 1215 West Cumberland Avenue, Room 229 Jessie Harris Building, Knoxville, TN 37996, USA.

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http://bmccomplementalternmed.biomedcentral.com/articles/10.
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http://dx.doi.org/10.1186/1472-6882-14-68DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3938081PMC
February 2014

Endocannabinoids and obesity.

Vitam Horm 2013 ;91:325-68

Department of Nutrition, University of Tennessee at Knoxville, Knoxville, Tennessee, USA.

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https://linkinghub.elsevier.com/retrieve/pii/B97801240776690
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http://dx.doi.org/10.1016/B978-0-12-407766-9.00014-6DOI Listing
December 2013

Activation of nucleotide oligomerization domain containing protein 1 induces lipolysis through NF-κB and the lipolytic PKA activation in 3T3-L1 adipocytes.

Biochem Cell Biol 2013 Dec 26;91(6):428-34. Epub 2013 Jun 26.

a Department of Nutrition, University of Tennessee, 1215 W. Cumberland Ave., Knoxville, TN, USA.

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http://dx.doi.org/10.1139/bcb-2013-0049DOI Listing
December 2013

Transparent dispersions of milk-fat-based nanostructured lipid carriers for delivery of β-carotene.

J Agric Food Chem 2013 Oct 19;61(39):9435-43. Epub 2013 Sep 19.

Department of Food Science and Technology, ‡Department of Biosystems Engineering and Soil Science, and §Department of Nutrition, University of Tennessee , Knoxville, Tennessee 37996, United States.

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http://dx.doi.org/10.1021/jf403512cDOI Listing
October 2013

Vitamin A status affects obesity development and hepatic expression of key genes for fuel metabolism in Zucker fatty rats.

Biochem Cell Biol 2012 Aug 3;90(4):548-57. Epub 2012 May 3.

The Diabetes Center at Wuhan Central Hospital, No. 26 Shengli Road, Jiangan District, Wuhan, Hubei 430014, China.

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http://dx.doi.org/10.1139/o2012-012DOI Listing
August 2012

Roles of vitamin A status and retinoids in glucose and fatty acid metabolism.

Biochem Cell Biol 2012 Apr 31;90(2):142-52. Epub 2012 Jan 31.

The Diabetes Center, Wuhan Central Hospital, Wuhan, Hubei 430014, China.

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http://dx.doi.org/10.1139/o11-079DOI Listing
April 2012

Insulin-regulated Srebp-1c and Pck1 mRNA expression in primary hepatocytes from zucker fatty but not lean rats is affected by feeding conditions.

PLoS One 2011 22;6(6):e21342. Epub 2011 Jun 22.

Department of Nutrition, University of Tennessee at Knoxville, Knoxville, Tennessee, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0021342PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3120864PMC
November 2011

Zyflamend reduces the expression of androgen receptor in a model of castrate-resistant prostate cancer.

Nutr Cancer 2011 Nov 29;63(8):1287-96. Epub 2011 Sep 29.

Department of Nutrition, University of Tennessee, Knoxville, Tennessee 37996-1920, USA.

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http://dx.doi.org/10.1080/01635581.2011.606956DOI Listing
November 2011

Berberine regulated Gck, G6pc, Pck1 and Srebp-1c expression and activated AMP-activated protein kinase in primary rat hepatocytes.

Int J Biol Sci 2011 24;7(5):673-84. Epub 2011 May 24.

College of Pharmacy, South-Central University for Nationalities, Wuhan, Hubei 430073, China.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3107476PMC
October 2011

Retinoids induced Pck1 expression and attenuated insulin-mediated suppression of its expression via activation of retinoic acid receptor in primary rat hepatocytes.

Mol Cell Biochem 2011 Sep 26;355(1-2):1-8. Epub 2011 Apr 26.

Department of Nutrition, University of Tennessee at Knoxville, 229 Jessie Harris Building, 1215 West Cumberland Avenue, Knoxville, TN 37996, USA.

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http://dx.doi.org/10.1007/s11010-011-0831-4DOI Listing
September 2011

Retinoids synergized with insulin to induce Srebp-1c expression and activated its promoter via the two liver X receptor binding sites that mediate insulin action.

Biochem Biophys Res Commun 2011 Mar 18;406(2):268-72. Epub 2011 Feb 18.

Department of Nutrition, University of Tennessee at Knoxville, Knoxville, TN 37996, USA.

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http://dx.doi.org/10.1016/j.bbrc.2011.02.031DOI Listing
March 2011

Retinoids synergize with insulin to induce hepatic Gck expression.

Biochem J 2009 May;419(3):645-53

Department of Nutrition, University of Tennessee at Knoxville, Knoxville, TN 37996, U.S.A.

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http://dx.doi.org/10.1042/BJ20082368DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3789248PMC
May 2009

Understanding of basic mechanisms of beta-cell function and survival: prelude to new diabetes therapies.

Cell Biochem Biophys 2004 ;40(3 Suppl):159-68

Sarah W. Stedman Nutrition and Metabolism Center, and Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC, USA.

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April 2009

Liver lipid molecules induce PEPCK-C gene transcription and attenuate insulin action.

Authors:
Guoxun Chen

Biochem Biophys Res Commun 2007 Sep 27;361(3):805-10. Epub 2007 Jul 27.

Department of Nutrition, The University of Tennessee at Knoxville, 229 Jessie Harris Building, 1215 West Cumberland Avenue, Knoxville, TN 37996, USA.

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http://dx.doi.org/10.1016/j.bbrc.2007.07.108DOI Listing
September 2007

Central role for liver X receptor in insulin-mediated activation of Srebp-1c transcription and stimulation of fatty acid synthesis in liver.

Proc Natl Acad Sci U S A 2004 Aug 20;101(31):11245-50. Epub 2004 Jul 20.

Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX 75390-9046, USA.

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http://dx.doi.org/10.1073/pnas.0404297101DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC509189PMC
August 2004

Discrete and complementary mechanisms of protection of beta-cells against cytokine-induced and oxidative damage achieved by bcl-2 overexpression and a cytokine selection strategy.

Diabetes 2003 Jun;52(6):1423-32

Touchstone Center for Diabetes Research, Department of Biochemistry and Biomedical Engineering Program, University of Texas Southwestern Medical Center, Dallas, TX, USA.

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June 2003