Guowang Xu

Guowang Xu

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Removal of false positive features to generate authentic peak table for high-resolution mass spectrometry-based metabolomics study.

Anal Chim Acta 2019 Aug 10;1067:79-87. Epub 2019 Apr 10.

CAS Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, 116023, China. Electronic address:

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http://dx.doi.org/10.1016/j.aca.2019.04.011DOI Listing
August 2019

Linking bioenergetic function of mitochondria to tissue-specific molecular fingerprints

Am J Physiol Endocrinol Metab 2019 06 18. Epub 2019 Jun 18.

Institute for Clinical Chemistry and Pathobiochemistry, Department for Diagnostic Laboratory Medicine, University Hospital Tuebingen, Tuebingen. Institute for Diabetes Research and Metabolic Diseases of the Helmholtz Center Munich at the University of Tuebingen, Tuebingen, Germany. German Center for Diabetes Research (DZD), Germany.

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http://dx.doi.org/10.1152/ajpendo.00088.2019DOI Listing
June 2019

Serum Metabolomics Study of Nonsmoking Female Patients with Non-Small Cell Lung Cancer Using Gas Chromatography-Mass Spectrometry.

J Proteome Res 2019 May 29;18(5):2175-2184. Epub 2019 Mar 29.

CAS Key Laboratory of Separation Science for Analytical Chemistry , Dalian Institute of Chemical Physics, Chinese Academy of Sciences , Dalian 116023 , China.

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http://dx.doi.org/10.1021/acs.jproteome.9b00069DOI Listing
May 2019

Comprehensive Profiling by Non-targeted Stable Isotope Tracing Capillary Electrophoresis-Mass Spectrometry: A New Tool Complementing Metabolomic Analyses of Polar Metabolites.

Chemistry 2019 Apr 25;25(21):5427-5432. Epub 2019 Mar 25.

CAS Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, 116023, China.

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http://dx.doi.org/10.1002/chem.201900539DOI Listing
April 2019

Integrated Metabolomics and Lipidomics Analyses Reveal Metabolic Reprogramming in Human Glioma with IDH1 Mutation.

J Proteome Res 2019 Mar 9;18(3):960-969. Epub 2019 Jan 9.

CAS Key Laboratory of Separation Science for Analytical Chemistry , Dalian Institute of Chemical Physics, Chinese Academy of Sciences , Dalian 116023 , P. R. China.

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http://pubs.acs.org/doi/10.1021/acs.jproteome.8b00663
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http://dx.doi.org/10.1021/acs.jproteome.8b00663DOI Listing
March 2019

A comprehensive strategy for studying protein-metabolite interactions by metabolomics and native mass spectrometry.

Talanta 2019 Mar 10;194:63-72. Epub 2018 Oct 10.

CAS Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China. Electronic address:

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http://dx.doi.org/10.1016/j.talanta.2018.10.010DOI Listing
March 2019

Metabolic phenotypes and the gut microbiota in response to dietary resistant starch type 2 in normal-weight subjects: a randomized crossover trial.

Sci Rep 2019 Mar 20;9(1):4736. Epub 2019 Mar 20.

Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People's Hospital; Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Clinical Center of Diabetes, Shanghai, 200233, China.

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http://dx.doi.org/10.1038/s41598-018-38216-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6426958PMC
March 2019

Metabolomics profiling of metformin-mediated metabolic reprogramming bypassing AMPKα.

Metabolism 2019 02 20;91:18-29. Epub 2018 Nov 20.

CAS Key Laboratory of Separation Science for Analytical Chemistry, Scientific Research Center for Translational Medicine, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China; University of Chinese Academy of Sciences, Beijing 100049, China. Electronic address:

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http://dx.doi.org/10.1016/j.metabol.2018.11.010DOI Listing
February 2019

Carboxymethylated polyethylenimine modified magnetic nanoparticles specifically for purification of His-tagged protein.

J Sep Sci 2019 Feb 13;42(3):744-753. Epub 2018 Dec 13.

CAS Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, P. R. China.

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http://dx.doi.org/10.1002/jssc.201800969DOI Listing
February 2019

ORP4L Extracts and Presents PIP from Plasma Membrane for PLCβ3 Catalysis: Targeting It Eradicates Leukemia Stem Cells.

Cell Rep 2019 Feb;26(8):2166-2177.e9

Key Laboratory of Functional Protein Research of Guangdong Higher Education Institutes, Department of Biology, Jinan University, Guangzhou 510632, China. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2019.01.082DOI Listing
February 2019

Modified metabolites mapping by liquid chromatography-high resolution mass spectrometry using full scan/all ion fragmentation/neutral loss acquisition.

J Chromatogr A 2019 Jan 11;1583:80-87. Epub 2018 Nov 11.

CAS Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China.

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https://linkinghub.elsevier.com/retrieve/pii/S00219673183139
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http://dx.doi.org/10.1016/j.chroma.2018.11.014DOI Listing
January 2019

Preface.

Anal Chim Acta 2018 Dec;1037:1-2

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https://linkinghub.elsevier.com/retrieve/pii/S00032670183113
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http://dx.doi.org/10.1016/j.aca.2018.09.046DOI Listing
December 2018

Serum or plasma, what is the difference? Investigations to facilitate the sample material selection decision making process for metabolomics studies and beyond.

Anal Chim Acta 2018 Dec 21;1037:293-300. Epub 2018 Mar 21.

Division of Clinical Chemistry and Pathobiochemistry (Central Laboratory), University Hospital Tübingen, 72076 Tübingen, Germany; Core Facility DZD Clinical Chemistry Laboratory, Institute for Diabetes Research and Metabolic Diseases of the Helmholtz Center Munich at the University of Tuebingen, Tübingen, Germany; German Center for Diabetes Research (DZD), Germany. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00032670183037
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http://dx.doi.org/10.1016/j.aca.2018.03.009DOI Listing
December 2018

Recent advances in using mass spectrometry for mitochondrial metabolomics and lipidomics - A review.

Anal Chim Acta 2018 Dec 19;1037:3-12. Epub 2017 Dec 19.

CAS Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China. Electronic address:

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http://dx.doi.org/10.1016/j.aca.2017.11.080DOI Listing
December 2018

Current and future perspectives of functional metabolomics in disease studies-A review.

Authors:
Min Yan Guowang Xu

Anal Chim Acta 2018 Dec 17;1037:41-54. Epub 2018 Apr 17.

CAS Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, 116023, China; University of Chinese Academy of Sciences, Beijing, 100049, China. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00032670183048
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http://dx.doi.org/10.1016/j.aca.2018.04.006DOI Listing
December 2018

Deep Annotation of Hydroxycinnamic Acid Amides in Plants Based on Ultra-High-Performance Liquid Chromatography-High-Resolution Mass Spectrometry and Its In Silico Database.

Anal Chem 2018 12 4;90(24):14321-14330. Epub 2018 Dec 4.

CAS Key Laboratory of Separation Science for Analytical Chemistry , Dalian Institute of Chemical Physics, Chinese Academy of Sciences , Dalian 116023 , China.

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http://dx.doi.org/10.1021/acs.analchem.8b03654DOI Listing
December 2018

Plasma bile acid changes in type 2 diabetes correlated with insulin secretion in two-step hyperglycemic clamp.

J Diabetes 2018 Nov 28;10(11):874-885. Epub 2018 May 28.

Shanghai National Research Centre for Endocrine and Metabolic Diseases, State Key Laboratory of Medical Genomics, Shanghai Institute for Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

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http://doi.wiley.com/10.1111/1753-0407.12771
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http://dx.doi.org/10.1111/1753-0407.12771DOI Listing
November 2018

USP10 suppresses tumor progression by inhibiting mTOR activation in hepatocellular carcinoma.

Cancer Lett 2018 Nov 26;436:139-148. Epub 2018 Jul 26.

The First Affiliated Hospital of Dalian Medical University, Dalian Medical University, Dalian, 116000, China. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S03043835183049
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http://dx.doi.org/10.1016/j.canlet.2018.07.032DOI Listing
November 2018

Integration of Proteomics and Metabolomics Revealed Metabolite-Protein Networks in ACTH-Secreting Pituitary Adenoma.

Front Endocrinol (Lausanne) 2018 23;9:678. Epub 2018 Nov 23.

Beijing Neurosurgical Institute, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.

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http://dx.doi.org/10.3389/fendo.2018.00678DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6266547PMC
November 2018

Ion-Pair Selection Method for Pseudotargeted Metabolomics Based on SWATH MS Acquisition and Its Application in Differential Metabolite Discovery of Type 2 Diabetes.

Anal Chem 2018 10 10;90(19):11401-11408. Epub 2018 Sep 10.

CAS Key Laboratory of Separation Science for Analytical Chemistry , Dalian Institute of Chemical Physics, Chinese Academy of Sciences , 457 Zhongshan Road , Dalian 116023 , P. R. China.

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http://dx.doi.org/10.1021/acs.analchem.8b02377DOI Listing
October 2018

A high throughput metabolomics method and its application in female serum samples in a normal menstrual cycle based on liquid chromatography-mass spectrometry.

Talanta 2018 Aug 28;185:483-490. Epub 2018 Mar 28.

CAS Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00399140183032
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http://dx.doi.org/10.1016/j.talanta.2018.03.087DOI Listing
August 2018

Surface-bonded amide-functionalized imidazolium ionic liquid as stationary phase for hydrophilic interaction liquid chromatography.

J Chromatogr A 2018 Jul 12;1559:141-148. Epub 2017 Jul 12.

CAS Key Laboratory of Separation Sciences for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, 116023, China. Electronic address:

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http://dx.doi.org/10.1016/j.chroma.2017.07.037DOI Listing
July 2018

Metabolomics and transcriptomics profiles reveal the dysregulation of the tricarboxylic acid cycle and related mechanisms in prostate cancer.

Int J Cancer 2018 07 6;143(2):396-407. Epub 2018 Mar 6.

CAS Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, 457 Zhongshan Road, Dalian, China.

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http://doi.wiley.com/10.1002/ijc.31313
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http://dx.doi.org/10.1002/ijc.31313DOI Listing
July 2018

Synthesis of magnetic mesoporous metal-organic framework-5 for the effective enrichment of malachite green and crystal violet in fish samples.

J Chromatogr A 2018 Jul 9;1560:19-25. Epub 2018 May 9.

CAS Key Laboratory of Separation Sciences for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China.

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http://dx.doi.org/10.1016/j.chroma.2018.05.016DOI Listing
July 2018

Screening and Determination of Potential Risk Substances Based on Liquid Chromatography-High-Resolution Mass Spectrometry.

Anal Chem 2018 07 26;90(14):8454-8461. Epub 2018 Jun 26.

CAS Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics , Chinese Academy of Sciences , Dalian 116023 , China.

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http://dx.doi.org/10.1021/acs.analchem.8b01153DOI Listing
July 2018

Reply.

Hepatology 2018 06 27;67(6):2483-2484. Epub 2018 Apr 27.

CAS Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, China.

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http://dx.doi.org/10.1002/hep.29868DOI Listing
June 2018

Activation of choline kinase drives aberrant choline metabolism in esophageal squamous cell carcinomas.

J Pharm Biomed Anal 2018 Jun 31;155:148-156. Epub 2018 Mar 31.

CAS Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China. Electronic address:

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http://dx.doi.org/10.1016/j.jpba.2018.03.062DOI Listing
June 2018

Comprehensive Strategy to Construct In-House Database for Accurate and Batch Identification of Small Molecular Metabolites.

Anal Chem 2018 06 8;90(12):7635-7643. Epub 2018 Jun 8.

CAS Key Laboratory of Separation Science for Analytical Chemistry , Dalian Institute of Chemical Physics, Chinese Academy of Science , Dalian 116023 , China.

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http://pubs.acs.org/doi/10.1021/acs.analchem.8b01482
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http://dx.doi.org/10.1021/acs.analchem.8b01482DOI Listing
June 2018

Development of a High Coverage Pseudotargeted Lipidomics Method Based on Ultra-High Performance Liquid Chromatography-Mass Spectrometry.

Anal Chem 2018 06 8;90(12):7608-7616. Epub 2018 Jun 8.

CAS Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics , Chinese Academy of Sciences , Dalian , Liaoning , 116023 , China.

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http://dx.doi.org/10.1021/acs.analchem.8b01331DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6242181PMC
June 2018

Strategy for Comprehensive Identification of Acylcarnitines Based on Liquid Chromatography-High-Resolution Mass Spectrometry.

Anal Chem 2018 05 20;90(9):5712-5718. Epub 2018 Apr 20.

CAS Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics , Chinese Academy of Sciences , Dalian 116023 , China.

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http://dx.doi.org/10.1021/acs.analchem.7b05471DOI Listing
May 2018

Serum Metabolomics Study of Gliclazide-Modified-Release-Treated Type 2 Diabetes Mellitus Patients Using a Gas Chromatography-Mass Spectrometry Method.

J Proteome Res 2018 04 28;17(4):1575-1585. Epub 2018 Feb 28.

CAS Key Laboratory of Separation Science for Analytical Chemistry , Dalian Institute of Chemical Physics, Chinese Academy of Sciences , Dalian 116023 , China.

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http://dx.doi.org/10.1021/acs.jproteome.7b00866DOI Listing
April 2018

Metabolomics Toward Biomarker Discovery.

Methods Mol Biol 2017 ;1619:467-475

Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, 457 Zhongshan Road, 16023, Dalian, China.

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http://dx.doi.org/10.1007/978-1-4939-7057-5_32DOI Listing
March 2018

A High-Fat Diet Rich in Saturated and Mono-Unsaturated Fatty Acids Induces Disturbance of Thyroid Lipid Profile and Hypothyroxinemia in Male Rats.

Mol Nutr Food Res 2018 03 28;62(6):e1700599. Epub 2018 Feb 28.

Department of Endocrinology, Shandong Provincial Hospital affiliated to Shandong University, Ji-nan, China.

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http://dx.doi.org/10.1002/mnfr.201700599DOI Listing
March 2018

Molecular interaction study of flavonoids with human serum albumin using native mass spectrometry and molecular modeling.

Anal Bioanal Chem 2018 Jan 24;410(3):827-837. Epub 2017 Aug 24.

CAS Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, Liaoning, 116023, China.

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http://dx.doi.org/10.1007/s00216-017-0564-7DOI Listing
January 2018

Metabolic changes in primary, secondary, and lipid metabolism in tobacco leaf in response to topping.

Anal Bioanal Chem 2018 Jan 19;410(3):839-851. Epub 2017 Sep 19.

CAS Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, 457 Zhongshan Road, Dalian, Liaoning, 116023, China.

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http://dx.doi.org/10.1007/s00216-017-0596-zDOI Listing
January 2018

Global Metabolic Profiling Identifies a Pivotal Role of Proline and Hydroxyproline Metabolism in Supporting Hypoxic Response in Hepatocellular Carcinoma.

Clin Cancer Res 2018 01 30;24(2):474-485. Epub 2017 Oct 30.

Scientific Research Center for Translational Medicine, Department of Biotechnology, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, China.

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http://clincancerres.aacrjournals.org/lookup/doi/10.1158/107
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http://dx.doi.org/10.1158/1078-0432.CCR-17-1707DOI Listing
January 2018

Controlling electronic properties of MoS/graphene oxide heterojunctions for enhancing photocatalytic performance: the role of oxygen.

Phys Chem Chem Phys 2018 Jan;20(3):1974-1983

School of Science, Hubei University of Technology, Wuhan 430068, China.

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http://dx.doi.org/10.1039/c7cp07303hDOI Listing
January 2018

Determination of candidate metabolite biomarkers associated with recurrence of HCV-related hepatocellular carcinoma.

Oncotarget 2018 Jan 15;9(5):6245-6258. Epub 2017 Dec 15.

CAS Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, China.

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http://dx.doi.org/10.18632/oncotarget.23500DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5814209PMC
January 2018

Comprehensive Analysis of Short-, Medium-, and Long-Chain Acyl-Coenzyme A by Online Two-Dimensional Liquid Chromatography/Mass Spectrometry.

Anal Chem 2017 12 15;89(23):12902-12908. Epub 2017 Nov 15.

CAS Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences , Dalian 116023, China.

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http://dx.doi.org/10.1021/acs.analchem.7b03659DOI Listing
December 2017

Analyses of gut microbiota and plasma bile acids enable stratification of patients for antidiabetic treatment.

Nat Commun 2017 11 27;8(1):1785. Epub 2017 Nov 27.

Shanghai National Research Centre for Endocrine and Metabolic Diseases, State Key Laboratory of Medical Genomics, Shanghai Institute for Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, 200025, Shanghai, China.

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http://dx.doi.org/10.1038/s41467-017-01682-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5702614PMC
November 2017

Identification of related metabolic pathways in prostate cancer.

Oncotarget 2017 Nov 3;8(61):103032-103046. Epub 2017 Oct 3.

CAS Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China.

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http://dx.doi.org/10.18632/oncotarget.21460DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5732708PMC
November 2017

Metabolic profiling analysis of Siraitia grosvenorii revealed different characteristics of green fruit and saccharified yellow fruit.

J Pharm Biomed Anal 2017 Oct 20;145:158-168. Epub 2017 Jun 20.

CAS Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China; University of Chinese Academy of Sciences, Beijing 100049, China. Electronic address:

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http://dx.doi.org/10.1016/j.jpba.2017.06.046DOI Listing
October 2017

An alignment algorithm for LC-MS-based metabolomics dataset assisted by MS/MS information.

Anal Chim Acta 2017 Oct 4;990:96-102. Epub 2017 Aug 4.

CAS Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China.

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http://dx.doi.org/10.1016/j.aca.2017.07.058DOI Listing
October 2017

Next-generation transgenic cotton: pyramiding RNAi and Bt counters insect resistance.

Plant Biotechnol J 2017 Sep 16;15(9):1204-1213. Epub 2017 Mar 16.

State Key Laboratory of Plant Genomics and National Center for Plant Gene Research (Beijing), Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, China.

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http://dx.doi.org/10.1111/pbi.12709DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5552478PMC
September 2017

High-throughput metabolic profiling based on small amount of hepatic cells.

Electrophoresis 2017 09 30;38(18):2296-2303. Epub 2017 May 30.

Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, P. R. China.

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http://dx.doi.org/10.1002/elps.201600539DOI Listing
September 2017

A Large-scale, multicenter serum metabolite biomarker identification study for the early detection of hepatocellular carcinoma.

Hepatology 2017 Sep 28. Epub 2017 Sep 28.

CAS Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, China.

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http://dx.doi.org/10.1002/hep.29561DOI Listing
September 2017

Plasma metabolomics profiling of maintenance hemodialysis based on capillary electrophoresis - time of flight mass spectrometry.

Sci Rep 2017 08 15;7(1):8150. Epub 2017 Aug 15.

CAS Key Laboratory of Separation Sciences for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, 457 Zhongshan Road, Dalian, 116023, China.

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http://dx.doi.org/10.1038/s41598-017-08327-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5557835PMC
August 2017

Altered Lipid Metabolism in Recovered SARS Patients Twelve Years after Infection.

Sci Rep 2017 08 22;7(1):9110. Epub 2017 Aug 22.

Key Research Laboratory for Infectious Disease Prevention for State Administration of Traditional Chinese Medicine, Tianjin Institute of Respiratory Diseases, Haihe Clinical College of Tianjin Medical University, Tianjin, China.

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http://dx.doi.org/10.1038/s41598-017-09536-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5567209PMC
August 2017

Simultaneous metabolomics and lipidomics analysis based on novel heart-cutting two-dimensional liquid chromatography-mass spectrometry.

Anal Chim Acta 2017 May 20;966:34-40. Epub 2017 Mar 20.

CAS Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China. Electronic address:

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http://dx.doi.org/10.1016/j.aca.2017.03.004DOI Listing
May 2017

Discovery and validation of potential urinary biomarkers for bladder cancer diagnosis using a pseudotargeted GC-MS metabolomics method.

Oncotarget 2017 Mar;8(13):20719-20728

Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China.

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http://dx.doi.org/10.18632/oncotarget.14988DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5400539PMC
March 2017

Online Three Dimensional Liquid Chromatography/Mass Spectrometry Method for the Separation of Complex Samples.

Anal Chem 2017 02 10;89(3):1433-1438. Epub 2017 Jan 10.

CAS Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences , Dalian 116023, China.

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http://dx.doi.org/10.1021/acs.analchem.6b04401DOI Listing
February 2017

Lysophosphatidylcholines activate PPARδ and protect human skeletal muscle cells from lipotoxicity.

Biochim Biophys Acta 2016 12 30;1861(12 Pt A):1980-1992. Epub 2016 Sep 30.

Division of Pathobiochemistry and Clinical Chemistry, University Tübingen, Otfried-Müller-Strasse 10, 72076 Tübingen, Germany; Institute for Diabetes Research and Metabolic Diseases of the Helmholtz Zentrum München at the University of Tübingen, Otfried-Müller-Strasse 10, 72076 Tübingen, Germany; German Center for Diabetes Research (DZD), Ingolstädter Landstrasse 1, 85764 München-Neuherberg, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.bbalip.2016.09.020DOI Listing
December 2016

Application of LC-MS-based metabolomics method in differentiating septic survivors from non-survivors.

Anal Bioanal Chem 2016 Nov 10;408(27):7641-7649. Epub 2016 Sep 10.

Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, 457 Zhongshan Road, Dalian, Liaoning, 116023, China.

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http://dx.doi.org/10.1007/s00216-016-9845-9DOI Listing
November 2016

Comprehensive investigation of tobacco leaves during natural early senescence via multi-platform metabolomics analyses.

Sci Rep 2016 11 29;6:37976. Epub 2016 Nov 29.

Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China.

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http://dx.doi.org/10.1038/srep37976DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5126694PMC
November 2016

Plasma lipidomics reveals potential lipid markers of major depressive disorder.

Anal Bioanal Chem 2016 Sep 25;408(23):6497-507. Epub 2016 Jul 25.

Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, 457 Zhongshan Road, Dalian, Liaoning, 116023, China.

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http://dx.doi.org/10.1007/s00216-016-9768-5DOI Listing
September 2016

The development of plasma pseudotargeted GC-MS metabolic profiling and its application in bladder cancer.

Anal Bioanal Chem 2016 Sep 29;408(24):6741-9. Epub 2016 Jul 29.

Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, 457 Zhongshan Road, Dalian, Liaoning, 116023, China.

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http://dx.doi.org/10.1007/s00216-016-9797-0DOI Listing
September 2016

Nontargeted Screening Method for Illegal Additives Based on Ultrahigh-Performance Liquid Chromatography-High-Resolution Mass Spectrometry.

Anal Chem 2016 09 12;88(17):8870-7. Epub 2016 Aug 12.

Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Science , Dalian 116023, China.

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http://dx.doi.org/10.1021/acs.analchem.6b02482DOI Listing
September 2016

High-sensitivity detection of biogenic amines with multiple reaction monitoring in fish based on benzoyl chloride derivatization.

J Chromatogr A 2016 Sep 30;1465:30-7. Epub 2016 Aug 30.

Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China; University of Chinese Academy of Sciences, Beijing 100049, China. Electronic address:

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http://dx.doi.org/10.1016/j.chroma.2016.08.067DOI Listing
September 2016

Exploration of the serum metabolite signature in patients with rheumatoid arthritis using gas chromatography-mass spectrometry.

J Pharm Biomed Anal 2016 Aug 4;127:60-7. Epub 2016 Feb 4.

Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, 457 Zhongshan Road, Dalian 116023, China. Electronic address:

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http://dx.doi.org/10.1016/j.jpba.2016.02.004DOI Listing
August 2016

Oral secretions from Mythimna separata insects specifically induce defence responses in maize as revealed by high-dimensional biological data.

Plant Cell Environ 2016 08 5;39(8):1749-1766. Epub 2016 May 5.

Department of Economic Plants and Biotechnology, Yunnan Key Laboratory for Wild Plant Resources, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China.

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http://dx.doi.org/10.1111/pce.12735DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5295635PMC
August 2016

Effect of a traditional Chinese medicine prescription Quzhuotongbi decoction on hyperuricemia model rats studied by using serum metabolomics based on gas chromatography-mass spectrometry.

J Chromatogr B Analyt Technol Biomed Life Sci 2016 Jul 21;1026:272-278. Epub 2015 Nov 21.

Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, 457 Zhongshan Road, Dalian 116023, China. Electronic address:

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http://dx.doi.org/10.1016/j.jchromb.2015.10.031DOI Listing
July 2016

Exercise-Induced Secretion of FGF21 and Follistatin Are Blocked by Pancreatic Clamp and Impaired in Type 2 Diabetes.

J Clin Endocrinol Metab 2016 07 10;101(7):2816-25. Epub 2016 May 10.

The Centre of Inflammation and Metabolism and the Centre for Physical Activity Research (J.S.H., B.K.P., P.P.) and Department of Clinical Biochemistry (J.S.H., P.P.), Rigshospitalet, University of Copenhagen, DK-2100 Copenhagen, Denmark; Key Laboratory of Separation Science for Analytical Chemistry (G.X.), Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China; Division of Pathobiochemistry and Clinical Chemistry (R.L., C.W.), Department of Internal Medicine IV and Institute for Diabetes Research and Metabolic Diseases (R.L., C.W.), Helmholtz Zentrum München, University Tuebingen, D-72074 Tuebingen, Germany; and German Center for Diabetes Research (R.L., C.W.), D-85764 Neuherberg, Germany.

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http://dx.doi.org/10.1210/jc.2016-1681DOI Listing
July 2016

Highly efficient solid-phase derivatization of sugar phosphates with titanium-immobilized hydrophilic polydopamine-coated silica.

J Chromatogr A 2016 Jul 16;1457:125-33. Epub 2016 Jun 16.

Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China. Electronic address:

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http://dx.doi.org/10.1016/j.chroma.2016.06.046DOI Listing
July 2016

A lipidomics study reveals hepatic lipid signatures associating with deficiency of the LDL receptor in a rat model.

Biol Open 2016 Jul 15;5(7):979-86. Epub 2016 Jul 15.

State Key Laboratory of Pharmaceutical Biotechnology and MOE Key Laboratory of Model Animal for Disease Study, Model Animal Research Center, Nanjing University, Pukou District, Nanjing 210061, China Collaborative Innovation Center of Genetics and Development, Shanghai 200438, China.

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http://dx.doi.org/10.1242/bio.019802DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4958281PMC
July 2016

Plasma Lipidomics Investigation of Hemodialysis Effects by Using Liquid Chromatography-Mass Spectrometry.

J Proteome Res 2016 06 19;15(6):1986-94. Epub 2016 May 19.

Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences , Dalian 116023, China.

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http://dx.doi.org/10.1021/acs.jproteome.6b00170DOI Listing
June 2016

Metabolomics Study of Roux-en-Y Gastric Bypass Surgery (RYGB) to Treat Type 2 Diabetes Patients Based on Ultraperformance Liquid Chromatography-Mass Spectrometry.

J Proteome Res 2016 Apr 25;15(4):1288-99. Epub 2016 Feb 25.

Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences , 457 Zhongshan Road, Dalian 116023, China.

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http://dx.doi.org/10.1021/acs.jproteome.6b00022DOI Listing
April 2016

Optimization of large-scale pseudotargeted metabolomics method based on liquid chromatography-mass spectrometry.

J Chromatogr A 2016 Mar 4;1437:127-136. Epub 2016 Feb 4.

Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China. Electronic address:

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http://dx.doi.org/10.1016/j.chroma.2016.01.078DOI Listing
March 2016

Hypotaurine evokes a malignant phenotype in glioma through aberrant hypoxic signaling.

Oncotarget 2016 Mar;7(12):15200-14

Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, China.

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http://dx.doi.org/10.18632/oncotarget.7710DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4924780PMC
March 2016

Serum metabolomics study of Traditional Chinese medicine formula intervention to polycystic ovary syndrome.

J Pharm Biomed Anal 2016 Feb 17;120:127-33. Epub 2015 Dec 17.

Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China.

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http://dx.doi.org/10.1016/j.jpba.2015.12.020DOI Listing
February 2016

A Novel Strategy for Large-Scale Metabolomics Study by Calibrating Gross and Systematic Errors in Gas Chromatography-Mass Spectrometry.

Anal Chem 2016 Feb 27;88(4):2234-42. Epub 2016 Jan 27.

Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences , Dalian 116023, China.

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http://dx.doi.org/10.1021/acs.analchem.5b03912DOI Listing
February 2016

Metabolic Profiling with Gas Chromatography-Mass Spectrometry and Capillary Electrophoresis-Mass Spectrometry Reveals the Carbon-Nitrogen Status of Tobacco Leaves Across Different Planting Areas.

J Proteome Res 2016 Feb 27;15(2):468-76. Epub 2016 Jan 27.

Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences , Dalian 116023, China.

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http://dx.doi.org/10.1021/acs.jproteome.5b00807DOI Listing
February 2016

Integration of lipidomics and transcriptomics unravels aberrant lipid metabolism and defines cholesteryl oleate as potential biomarker of prostate cancer.

Sci Rep 2016 Feb 11;6:20984. Epub 2016 Feb 11.

Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, 116023 Dalian, China.

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http://dx.doi.org/10.1038/srep20984DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4750101PMC
February 2016

Purity matters: A workflow for the valid high-resolution lipid profiling of mitochondria from cell culture samples.

Sci Rep 2016 Feb 19;6:21107. Epub 2016 Feb 19.

Division of Clinical Chemistry and Pathobiochemistry, Department of Diagnostic Laboratory Medicine, University Hospital Tuebingen, Tuebingen, Germany.

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http://www.nature.com/articles/srep21107
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http://dx.doi.org/10.1038/srep21107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4759577PMC
February 2016

Muscle and liver-specific alterations in lipid and acylcarnitine metabolism after a single bout of exercise in mice.

Sci Rep 2016 Feb 26;6:22218. Epub 2016 Feb 26.

Division of Clinical Chemistry and Pathobiochemistry, Department of Diagnostic Laboratory Medicine, University Hospital Tuebingen, Tuebingen, Germany.

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http://dx.doi.org/10.1038/srep22218DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4768182PMC
February 2016

Sample-directed pseudotargeted method for the metabolic profiling analysis of rice seeds based on liquid chromatography with mass spectrometry.

J Sep Sci 2016 Jan 7;39(2):247-55. Epub 2015 Dec 7.

Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, 116023, China.

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http://dx.doi.org/10.1002/jssc.201500858DOI Listing
January 2016

Integration of Metabolomics and Transcriptomics Reveals Major Metabolic Pathways and Potential Biomarker Involved in Prostate Cancer.

Mol Cell Proteomics 2016 Jan 6;15(1):154-63. Epub 2015 Nov 6.

From the ‡Department of Urology, Shanghai Changhai Hospital, Second Military Medical University, Shanghai, China,

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http://dx.doi.org/10.1074/mcp.M115.052381DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4762514PMC
January 2016

Multiple reaction monitoring-ion pair finder: a systematic approach to transform nontargeted mode to pseudotargeted mode for metabolomics study based on liquid chromatography-mass spectrometry.

Anal Chem 2015 30;87(10):5050-5. Epub 2015 Apr 30.

Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, Liaoning 116023, China.

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http://dx.doi.org/10.1021/acs.analchem.5b00615DOI Listing
December 2015

Recent development of ionic liquid stationary phases for liquid chromatography.

J Chromatogr A 2015 Nov 9;1420:1-15. Epub 2015 Oct 9.

Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China. Electronic address:

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http://dx.doi.org/10.1016/j.chroma.2015.09.090DOI Listing
November 2015

A metabolomics study delineating geographical location-associated primary metabolic changes in the leaves of growing tobacco plants by GC-MS and CE-MS.

Sci Rep 2015 Nov 9;5:16346. Epub 2015 Nov 9.

Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China.

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http://dx.doi.org/10.1038/srep16346DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4637841PMC
November 2015

Facile synthesis of Fe₃O₄@polyethyleneimine modified with 4-formylphenylboronic acid for the highly selective extraction of major catecholamines from human urine.

J Sep Sci 2015 Aug 30;38(16):2857-64. Epub 2015 Jun 30.

Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, China.

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http://dx.doi.org/10.1002/jssc.201500377DOI Listing
August 2015

Type 2 diabetes alters metabolic and transcriptional signatures of glucose and amino acid metabolism during exercise and recovery.

Diabetologia 2015 Aug 12;58(8):1845-54. Epub 2015 Jun 12.

Centre of Inflammation and Metabolism, Centre for Physical Activity Research, Department of Infectious Diseases, Rigshospitalet, Blegdamsvej 9, 2100, Copenhagen, Denmark.

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http://dx.doi.org/10.1007/s00125-015-3584-xDOI Listing
August 2015

Retention Time Prediction Improves Identification in Nontargeted Lipidomics Approaches.

Anal Chem 2015 Aug 22;87(15):7698-704. Epub 2015 Jul 22.

†Applied Bioinformatics, Center for Bioinformatics, Quantitative Biology Center, and Department of Computer Science, University of Tuebingen, Sand 14, 72076 Tuebingen, Baden-Württemberg, Germany.

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http://dx.doi.org/10.1021/acs.analchem.5b01139DOI Listing
August 2015

Lipidome and metabolome analysis of fresh tobacco leaves in different geographical regions using liquid chromatography-mass spectrometry.

Anal Bioanal Chem 2015 Jul 21;407(17):5009-20. Epub 2015 Feb 21.

Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, 116023, China.

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http://dx.doi.org/10.1007/s00216-015-8522-8DOI Listing
July 2015

Effects of pre-analytical processes on blood samples used in metabolomics studies.

Anal Bioanal Chem 2015 Jul 4;407(17):4879-92. Epub 2015 Mar 4.

Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, 116023, China.

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http://dx.doi.org/10.1007/s00216-015-8565-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4471316PMC
July 2015

Preparation of mesoporous SiO2@azobenzene-COOH chemoselective nanoprobes for comprehensive mapping of amino metabolites in human serum.

Chem Commun (Camb) 2015 Jun;51(56):11321-4

Key Lab of Separation Sciences for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, 116023, China.

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http://dx.doi.org/10.1039/c5cc03756eDOI Listing
June 2015

Discovery and validation of plasma biomarkers for major depressive disorder classification based on liquid chromatography-mass spectrometry.

J Proteome Res 2015 May 26;14(5):2322-30. Epub 2015 Mar 26.

†Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, 457 Zhongshan Road, Dalian 116023, China.

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http://dx.doi.org/10.1021/acs.jproteome.5b00144DOI Listing
May 2015

Preparation and evaluation of surface-bonded tricationic ionic liquid silica as stationary phases for high-performance liquid chromatography.

J Chromatogr A 2015 May 4;1396:62-71. Epub 2015 Apr 4.

Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China. Electronic address:

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http://dx.doi.org/10.1016/j.chroma.2015.03.081DOI Listing
May 2015

A data preprocessing strategy for metabolomics to reduce the mask effect in data analysis.

Front Mol Biosci 2015 2;2. Epub 2015 Feb 2.

Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences Dalian, China.

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http://dx.doi.org/10.3389/fmolb.2015.00004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4428451PMC
May 2015

A weighted relative difference accumulation algorithm for dynamic metabolomics data: long-term elevated bile acids are risk factors for hepatocellular carcinoma.

Sci Rep 2015 Mar 11;5:8984. Epub 2015 Mar 11.

Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, China.

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http://dx.doi.org/10.1038/srep08984DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4355672PMC
March 2015