Publications by authors named "Guowang Xu"

100Publications

Multiplatform Metabolomics Reveals Novel Serum Metabolite Biomarkers in Diabetic Retinopathy Subjects.

Adv Sci (Weinh) 2020 Nov 1;7(22):2001714. Epub 2020 Oct 1.

CAS Key Laboratory of Separation Science for Analytical Chemistry Dalian Institute of Chemical Physics Chinese Academy of Sciences 457 Zhongshan Road Dalian 116023 China.

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http://dx.doi.org/10.1002/advs.202001714DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7675050PMC
November 2020

A graph density-based strategy for features fusion from different peak extract software to achieve more metabolites in metabolic profiling from high-resolution mass spectrometry.

Anal Chim Acta 2020 Dec 16;1139:8-14. Epub 2020 Sep 16.

CAS Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, 116023, China. Electronic address:

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http://dx.doi.org/10.1016/j.aca.2020.09.029DOI Listing
December 2020

Rational Synthesis of Aptamer-Functionalized Polyethylenimine-Modified Magnetic Graphene Oxide Composites for Highly Efficient Enrichment and Comprehensive Metabolomics Analysis of Exosomes.

Anal Chem 2020 Nov 11. Epub 2020 Nov 11.

CAS Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China.

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http://dx.doi.org/10.1021/acs.analchem.0c03374DOI Listing
November 2020

Recent advances in analytical strategies for mass spectrometry-based lipidomics.

Anal Chim Acta 2020 Nov 30;1137:156-169. Epub 2020 Sep 30.

CAS Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, 116023, China; University of Chinese Academy of Sciences, Beijing, 100049, China. Electronic address:

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http://dx.doi.org/10.1016/j.aca.2020.09.060DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7525665PMC
November 2020

Serum Metabolomics for Biomarker Screening of Esophageal Squamous Cell Carcinoma and Esophageal Squamous Dysplasia Using Gas Chromatography-Mass Spectrometry.

ACS Omega 2020 Oct 12;5(41):26402-26412. Epub 2020 Oct 12.

Department of Cancer Epidemiology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, 17 South Panjiayuan Lane, Beijing 100021, China.

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http://dx.doi.org/10.1021/acsomega.0c02600DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7581083PMC
October 2020

Comparison of Erythrocyte Membrane Lipid Profiles between NAFLD Patients with or without Hyperlipidemia.

Int J Endocrinol 2020 16;2020:9501826. Epub 2020 Sep 16.

Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China.

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http://dx.doi.org/10.1155/2020/9501826DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7519187PMC
September 2020

A rapid GC method coupled with quadrupole or time of flight mass spectrometry for metabolomics analysis.

J Chromatogr B Analyt Technol Biomed Life Sci 2020 Dec 2;1160:122355. Epub 2020 Sep 2.

CAS Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China. Electronic address:

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http://dx.doi.org/10.1016/j.jchromb.2020.122355DOI Listing
December 2020

Lipid alterations and subtyping maker discovery of lung cancer based on nontargeted tissue lipidomics using liquid chromatography-mass spectrometry.

J Pharm Biomed Anal 2020 Oct 4;190:113520. Epub 2020 Aug 4.

CAS Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China; University of Chinese Academy of Sciences, Beijing 100049, China. Electronic address:

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http://dx.doi.org/10.1016/j.jpba.2020.113520DOI Listing
October 2020

Liquid Chromatography-Mass Spectrometry-Based Tissue Metabolic Profiling Reveals Major Metabolic Pathway Alterations and Potential Biomarkers of Lung Cancer.

J Proteome Res 2020 Sep 31;19(9):3750-3760. Epub 2020 Jul 31.

CAS Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China.

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http://dx.doi.org/10.1021/acs.jproteome.0c00285DOI Listing
September 2020

Alternate reversed-phase and hydrophilic interaction liquid chromatography coupled with mass spectrometry for broad coverage in metabolomics analysis.

J Chromatogr B Analyt Technol Biomed Life Sci 2020 Sep 14;1152:122266. Epub 2020 Jul 14.

CAS Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China. Electronic address:

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http://dx.doi.org/10.1016/j.jchromb.2020.122266DOI Listing
September 2020

Human Prostate Cancer is Characterized by an Increase in Urea Cycle Metabolites.

Cancers (Basel) 2020 07 6;12(7). Epub 2020 Jul 6.

Department of Internal Medicine, Division of Endocrinology, Diabetology and Nephrology, University Hospital Tübingen, 72076 Tübingen, Germany.

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http://dx.doi.org/10.3390/cancers12071814DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7408908PMC
July 2020

Liquid Chromatography-Mass Spectrometry-Based Nontargeted Metabolomics Predicts Prognosis of Hepatocellular Carcinoma after Curative Resection.

J Proteome Res 2020 08 17;19(8):3533-3541. Epub 2020 Jul 17.

CAS Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China.

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http://dx.doi.org/10.1021/acs.jproteome.0c00344DOI Listing
August 2020

Development of a plasma pseudotargeted metabolomics method based on ultra-high-performance liquid chromatography-mass spectrometry.

Nat Protoc 2020 08 24;15(8):2519-2537. Epub 2020 Jun 24.

CAS Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, China.

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http://dx.doi.org/10.1038/s41596-020-0341-5DOI Listing
August 2020

Synthesis of metal-organic framework-5@chitosan material for the analysis of microcystins and nodularin based on ultra-performance liquid chromatography-tandem mass spectrometry.

J Chromatogr A 2020 Jul 8;1623:461198. Epub 2020 May 8.

CAS Key Laboratory of Separation Sciences for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China.

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http://dx.doi.org/10.1016/j.chroma.2020.461198DOI Listing
July 2020

Untargeted Defining Protein-Metabolites Interaction Based on Label-Free Kinetic Size Exclusion Chromatography-Mass Spectrometry.

Anal Chem 2020 06 21;92(11):7657-7665. Epub 2020 May 21.

CAS Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China.

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http://dx.doi.org/10.1021/acs.analchem.0c00495DOI Listing
June 2020

Rapid lipidomic profiling based on ultra-high performance liquid chromatography-mass spectrometry and its application in diabetic retinopathy.

Anal Bioanal Chem 2020 Jun 24;412(15):3585-3594. Epub 2020 Apr 24.

CAS Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, 457 Zhongshan Road, Dalian, 116023, Liaoning, China.

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http://dx.doi.org/10.1007/s00216-020-02632-6DOI Listing
June 2020

Triptolide suppresses IDH1-mutated malignancy via Nrf2-driven glutathione metabolism.

Proc Natl Acad Sci U S A 2020 05 20;117(18):9964-9972. Epub 2020 Apr 20.

Neuro-Oncology Branch, Center for Cancer Research, National Cancer Institute, MD 20892;

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http://dx.doi.org/10.1073/pnas.1913633117DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7211987PMC
May 2020

Pseudotargeted Method Based on Parallel Column Two-Dimensional Liquid Chromatography-Mass Spectrometry for Broad Coverage of Metabolome and Lipidome.

Anal Chem 2020 04 9;92(8):6043-6050. Epub 2020 Apr 9.

CAS Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China.

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http://dx.doi.org/10.1021/acs.analchem.0c00372DOI Listing
April 2020

Serum lipidomic biomarkers for non-small cell lung cancer in nonsmoking female patients.

J Pharm Biomed Anal 2020 Jun 29;185:113220. Epub 2020 Feb 29.

CAS Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, 116023, China.

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http://dx.doi.org/10.1016/j.jpba.2020.113220DOI Listing
June 2020

Which is the urine sample material of choice for metabolomics-driven biomarker studies?

Anal Chim Acta 2020 Apr 16;1105:120-127. Epub 2020 Jan 16.

CAS Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, 16023, Dalian, China. Electronic address:

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http://dx.doi.org/10.1016/j.aca.2020.01.028DOI Listing
April 2020

Identification and regulation of the xenometabolite derivatives - and -3,4-methylene-heptanoylcarnitine in plasma and skeletal muscle of exercising humans.

Am J Physiol Endocrinol Metab 2020 05 26;318(5):E701-E709. Epub 2020 Feb 26.

Institute for Clinical Chemistry and Pathobiochemistry, University Hospital, Tuebingen, Germany.

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http://dx.doi.org/10.1152/ajpendo.00510.2019DOI Listing
May 2020

A multi-omics investigation of the molecular characteristics and classification of six metabolic syndrome relevant diseases.

Theranostics 2020 12;10(5):2029-2046. Epub 2020 Jan 12.

Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Key Clinical Center for Metabolic Diseases, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, 600 Yishan Road, Shanghai, 200233, People's Republic of China.

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http://dx.doi.org/10.7150/thno.41106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7019171PMC
January 2020

Protein profiling analysis based on matrix-assisted laser desorption/ionization-Fourier transform ion cyclotron resonance mass spectrometry and its application in typing Streptomyces isolates.

Talanta 2020 Feb 4;208:120439. Epub 2019 Oct 4.

CAS Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, 116023, China. Electronic address:

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http://dx.doi.org/10.1016/j.talanta.2019.120439DOI Listing
February 2020

Nanoparticle Conjugation of Ginsenoside Rg3 Inhibits Hepatocellular Carcinoma Development and Metastasis.

Small 2020 01 9;16(2):e1905233. Epub 2019 Dec 9.

Department of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital, School of Medicine, Zhejiang University, Key Laboratory of Combined Multi-organ Transplantation, Ministry of Public Health, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Hangzhou, 310003, China.

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http://dx.doi.org/10.1002/smll.201905233DOI Listing
January 2020

Parallel derivatization strategy coupled with liquid chromatography-mass spectrometry for broad coverage of steroid hormones.

J Chromatogr A 2020 Mar 13;1614:460709. Epub 2019 Nov 13.

CAS Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China. Electronic address:

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http://dx.doi.org/10.1016/j.chroma.2019.460709DOI Listing
March 2020

Metabolomics of lung cancer: Analytical platforms and their applications.

J Sep Sci 2020 Jan 10;43(1):120-133. Epub 2019 Dec 10.

CAS Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, P. R. China.

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http://dx.doi.org/10.1002/jssc.201900736DOI Listing
January 2020

[Identification of speckle type BTB/POZ protein mutation regulated key metabolic pathways by cell based proteomics and metabolomics].

Se Pu 2019 Aug;37(8):887-896

Chinese Academy of Sciecne Key Laboratory of Separation Sciences for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China.

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http://dx.doi.org/10.3724/SP.J.1123.2018.07008DOI Listing
August 2019

Untargeted Lipidomics Reveals Specific Lipid Abnormalities in Nonfunctioning Human Pituitary Adenomas.

J Proteome Res 2020 01 25;19(1):455-463. Epub 2019 Oct 25.

CAS Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics , Chinese Academy of Sciences , Dalian 116023 , China.

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http://dx.doi.org/10.1021/acs.jproteome.9b00637DOI Listing
January 2020

Sex-specific plasma metabolome signatures in major depressive disorder.

Psychiatry Clin Neurosci 2019 Nov 11;73(11):713-714. Epub 2019 Sep 11.

Department of Neurology, First Affiliated Hospital of Chongqing Medical University, Chongqing, China.

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http://dx.doi.org/10.1111/pcn.12925DOI Listing
November 2019

A novel analysis method for biomarker identification based on horizontal relationship: identifying potential biomarkers from large-scale hepatocellular carcinoma metabolomics data.

Anal Bioanal Chem 2019 Sep 5;411(24):6377-6386. Epub 2019 Aug 5.

CAS Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, 116023, China.

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http://dx.doi.org/10.1007/s00216-019-02011-wDOI Listing
September 2019

Synthesis of Polydopamine Hollow Capsules via a Polydopamine Mediated Silica Water Dissolution Process and Its Application for Enzyme Encapsulation.

Front Chem 2019 3;7:468. Epub 2019 Jul 3.

Department of Chemistry and Biotechnology, Faculty of Science, Engineering and Technology, Swinburne University of Technology, Hawthorn, VIC, Australia.

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http://dx.doi.org/10.3389/fchem.2019.00468DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6616115PMC
July 2019

Linking bioenergetic function of mitochondria to tissue-specific molecular fingerprints.

Am J Physiol Endocrinol Metab 2019 08 18;317(2):E374-E387. Epub 2019 Jun 18.

Institute for Clinical Chemistry and Pathobiochemistry, Department for Diagnostic Laboratory Medicine, University Hospital Tuebingen, Tuebingen, Germany.

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http://dx.doi.org/10.1152/ajpendo.00088.2019DOI Listing
August 2019

Removal of false positive features to generate authentic peak table for high-resolution mass spectrometry-based metabolomics study.

Anal Chim Acta 2019 Aug 10;1067:79-87. Epub 2019 Apr 10.

CAS Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, 116023, China. Electronic address:

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http://dx.doi.org/10.1016/j.aca.2019.04.011DOI Listing
August 2019

Metabolic phenotypes and the gut microbiota in response to dietary resistant starch type 2 in normal-weight subjects: a randomized crossover trial.

Sci Rep 2019 03 20;9(1):4736. Epub 2019 Mar 20.

Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People's Hospital; Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Clinical Center of Diabetes, Shanghai, 200233, China.

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http://dx.doi.org/10.1038/s41598-018-38216-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6426958PMC
March 2019

Serum Metabolomics Study of Nonsmoking Female Patients with Non-Small Cell Lung Cancer Using Gas Chromatography-Mass Spectrometry.

J Proteome Res 2019 05 29;18(5):2175-2184. Epub 2019 Mar 29.

CAS Key Laboratory of Separation Science for Analytical Chemistry , Dalian Institute of Chemical Physics, Chinese Academy of Sciences , Dalian 116023 , China.

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http://dx.doi.org/10.1021/acs.jproteome.9b00069DOI Listing
May 2019

Comprehensive Profiling by Non-targeted Stable Isotope Tracing Capillary Electrophoresis-Mass Spectrometry: A New Tool Complementing Metabolomic Analyses of Polar Metabolites.

Chemistry 2019 Apr 25;25(21):5427-5432. Epub 2019 Mar 25.

CAS Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, 116023, China.

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http://dx.doi.org/10.1002/chem.201900539DOI Listing
April 2019

ORP4L Extracts and Presents PIP from Plasma Membrane for PLCβ3 Catalysis: Targeting It Eradicates Leukemia Stem Cells.

Cell Rep 2019 02;26(8):2166-2177.e9

Key Laboratory of Functional Protein Research of Guangdong Higher Education Institutes, Department of Biology, Jinan University, Guangzhou 510632, China. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2019.01.082DOI Listing
February 2019

A comprehensive strategy for studying protein-metabolite interactions by metabolomics and native mass spectrometry.

Talanta 2019 Mar 10;194:63-72. Epub 2018 Oct 10.

CAS Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China. Electronic address:

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http://dx.doi.org/10.1016/j.talanta.2018.10.010DOI Listing
March 2019

Integrated Metabolomics and Lipidomics Analyses Reveal Metabolic Reprogramming in Human Glioma with IDH1 Mutation.

J Proteome Res 2019 03 9;18(3):960-969. Epub 2019 Jan 9.

CAS Key Laboratory of Separation Science for Analytical Chemistry , Dalian Institute of Chemical Physics, Chinese Academy of Sciences , Dalian 116023 , P. R. China.

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http://pubs.acs.org/doi/10.1021/acs.jproteome.8b00663
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http://dx.doi.org/10.1021/acs.jproteome.8b00663DOI Listing
March 2019

Integration of Proteomics and Metabolomics Revealed Metabolite-Protein Networks in ACTH-Secreting Pituitary Adenoma.

Front Endocrinol (Lausanne) 2018 23;9:678. Epub 2018 Nov 23.

Beijing Neurosurgical Institute, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.

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http://dx.doi.org/10.3389/fendo.2018.00678DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6266547PMC
November 2018

Carboxymethylated polyethylenimine modified magnetic nanoparticles specifically for purification of His-tagged protein.

J Sep Sci 2019 Feb 13;42(3):744-753. Epub 2018 Dec 13.

CAS Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, P. R. China.

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http://dx.doi.org/10.1002/jssc.201800969DOI Listing
February 2019

Modified metabolites mapping by liquid chromatography-high resolution mass spectrometry using full scan/all ion fragmentation/neutral loss acquisition.

J Chromatogr A 2019 Jan 11;1583:80-87. Epub 2018 Nov 11.

CAS Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China.

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https://linkinghub.elsevier.com/retrieve/pii/S00219673183139
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http://dx.doi.org/10.1016/j.chroma.2018.11.014DOI Listing
January 2019

Metabolomics profiling of metformin-mediated metabolic reprogramming bypassing AMPKα.

Metabolism 2019 02 20;91:18-29. Epub 2018 Nov 20.

CAS Key Laboratory of Separation Science for Analytical Chemistry, Scientific Research Center for Translational Medicine, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China; University of Chinese Academy of Sciences, Beijing 100049, China. Electronic address:

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http://dx.doi.org/10.1016/j.metabol.2018.11.010DOI Listing
February 2019

Deep Annotation of Hydroxycinnamic Acid Amides in Plants Based on Ultra-High-Performance Liquid Chromatography-High-Resolution Mass Spectrometry and Its In Silico Database.

Anal Chem 2018 12 4;90(24):14321-14330. Epub 2018 Dec 4.

CAS Key Laboratory of Separation Science for Analytical Chemistry , Dalian Institute of Chemical Physics, Chinese Academy of Sciences , Dalian 116023 , China.

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http://dx.doi.org/10.1021/acs.analchem.8b03654DOI Listing
December 2018

Current and future perspectives of functional metabolomics in disease studies-A review.

Authors:
Min Yan Guowang Xu

Anal Chim Acta 2018 Dec 17;1037:41-54. Epub 2018 Apr 17.

CAS Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, 116023, China; University of Chinese Academy of Sciences, Beijing, 100049, China. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00032670183048
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http://dx.doi.org/10.1016/j.aca.2018.04.006DOI Listing
December 2018

Recent advances in using mass spectrometry for mitochondrial metabolomics and lipidomics - A review.

Anal Chim Acta 2018 Dec 19;1037:3-12. Epub 2017 Dec 19.

CAS Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China. Electronic address:

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http://dx.doi.org/10.1016/j.aca.2017.11.080DOI Listing
December 2018

Serum or plasma, what is the difference? Investigations to facilitate the sample material selection decision making process for metabolomics studies and beyond.

Anal Chim Acta 2018 Dec 21;1037:293-300. Epub 2018 Mar 21.

Division of Clinical Chemistry and Pathobiochemistry (Central Laboratory), University Hospital Tübingen, 72076 Tübingen, Germany; Core Facility DZD Clinical Chemistry Laboratory, Institute for Diabetes Research and Metabolic Diseases of the Helmholtz Center Munich at the University of Tuebingen, Tübingen, Germany; German Center for Diabetes Research (DZD), Germany. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00032670183037
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http://dx.doi.org/10.1016/j.aca.2018.03.009DOI Listing
December 2018

Preface.

Anal Chim Acta 2018 Dec;1037:1-2

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https://linkinghub.elsevier.com/retrieve/pii/S00032670183113
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http://dx.doi.org/10.1016/j.aca.2018.09.046DOI Listing
December 2018

Ion-Pair Selection Method for Pseudotargeted Metabolomics Based on SWATH MS Acquisition and Its Application in Differential Metabolite Discovery of Type 2 Diabetes.

Anal Chem 2018 10 10;90(19):11401-11408. Epub 2018 Sep 10.

CAS Key Laboratory of Separation Science for Analytical Chemistry , Dalian Institute of Chemical Physics, Chinese Academy of Sciences , 457 Zhongshan Road , Dalian 116023 , P. R. China.

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http://dx.doi.org/10.1021/acs.analchem.8b02377DOI Listing
October 2018

USP10 suppresses tumor progression by inhibiting mTOR activation in hepatocellular carcinoma.

Cancer Lett 2018 11 26;436:139-148. Epub 2018 Jul 26.

The First Affiliated Hospital of Dalian Medical University, Dalian Medical University, Dalian, 116000, China. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S03043835183049
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http://dx.doi.org/10.1016/j.canlet.2018.07.032DOI Listing
November 2018

Screening and Determination of Potential Risk Substances Based on Liquid Chromatography-High-Resolution Mass Spectrometry.

Anal Chem 2018 07 26;90(14):8454-8461. Epub 2018 Jun 26.

CAS Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics , Chinese Academy of Sciences , Dalian 116023 , China.

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http://dx.doi.org/10.1021/acs.analchem.8b01153DOI Listing
July 2018

Development of a High Coverage Pseudotargeted Lipidomics Method Based on Ultra-High Performance Liquid Chromatography-Mass Spectrometry.

Anal Chem 2018 06 8;90(12):7608-7616. Epub 2018 Jun 8.

CAS Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics , Chinese Academy of Sciences , Dalian , Liaoning , 116023 , China.

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http://dx.doi.org/10.1021/acs.analchem.8b01331DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6242181PMC
June 2018

Comprehensive Strategy to Construct In-House Database for Accurate and Batch Identification of Small Molecular Metabolites.

Anal Chem 2018 06 8;90(12):7635-7643. Epub 2018 Jun 8.

CAS Key Laboratory of Separation Science for Analytical Chemistry , Dalian Institute of Chemical Physics, Chinese Academy of Science , Dalian 116023 , China.

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http://pubs.acs.org/doi/10.1021/acs.analchem.8b01482
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http://dx.doi.org/10.1021/acs.analchem.8b01482DOI Listing
June 2018

Synthesis of magnetic mesoporous metal-organic framework-5 for the effective enrichment of malachite green and crystal violet in fish samples.

J Chromatogr A 2018 Jul 9;1560:19-25. Epub 2018 May 9.

CAS Key Laboratory of Separation Sciences for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China.

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http://dx.doi.org/10.1016/j.chroma.2018.05.016DOI Listing
July 2018

A high throughput metabolomics method and its application in female serum samples in a normal menstrual cycle based on liquid chromatography-mass spectrometry.

Talanta 2018 Aug 28;185:483-490. Epub 2018 Mar 28.

CAS Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00399140183032
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http://dx.doi.org/10.1016/j.talanta.2018.03.087DOI Listing
August 2018

Plasma bile acid changes in type 2 diabetes correlated with insulin secretion in two-step hyperglycemic clamp.

J Diabetes 2018 Nov 28;10(11):874-885. Epub 2018 May 28.

Shanghai National Research Centre for Endocrine and Metabolic Diseases, State Key Laboratory of Medical Genomics, Shanghai Institute for Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

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http://doi.wiley.com/10.1111/1753-0407.12771
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http://dx.doi.org/10.1111/1753-0407.12771DOI Listing
November 2018

Strategy for Comprehensive Identification of Acylcarnitines Based on Liquid Chromatography-High-Resolution Mass Spectrometry.

Anal Chem 2018 05 20;90(9):5712-5718. Epub 2018 Apr 20.

CAS Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics , Chinese Academy of Sciences , Dalian 116023 , China.

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http://dx.doi.org/10.1021/acs.analchem.7b05471DOI Listing
May 2018

Activation of choline kinase drives aberrant choline metabolism in esophageal squamous cell carcinomas.

J Pharm Biomed Anal 2018 Jun 31;155:148-156. Epub 2018 Mar 31.

CAS Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China. Electronic address:

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http://dx.doi.org/10.1016/j.jpba.2018.03.062DOI Listing
June 2018

Reply.

Hepatology 2018 06 27;67(6):2483-2484. Epub 2018 Apr 27.

CAS Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, China.

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http://dx.doi.org/10.1002/hep.29868DOI Listing
June 2018

Determination of candidate metabolite biomarkers associated with recurrence of HCV-related hepatocellular carcinoma.

Oncotarget 2018 Jan 15;9(5):6245-6258. Epub 2017 Dec 15.

CAS Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, China.

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http://dx.doi.org/10.18632/oncotarget.23500DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5814209PMC
January 2018

Serum Metabolomics Study of Gliclazide-Modified-Release-Treated Type 2 Diabetes Mellitus Patients Using a Gas Chromatography-Mass Spectrometry Method.

J Proteome Res 2018 04 28;17(4):1575-1585. Epub 2018 Feb 28.

CAS Key Laboratory of Separation Science for Analytical Chemistry , Dalian Institute of Chemical Physics, Chinese Academy of Sciences , Dalian 116023 , China.

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http://dx.doi.org/10.1021/acs.jproteome.7b00866DOI Listing
April 2018

Metabolomics and transcriptomics profiles reveal the dysregulation of the tricarboxylic acid cycle and related mechanisms in prostate cancer.

Int J Cancer 2018 07 6;143(2):396-407. Epub 2018 Mar 6.

CAS Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, 457 Zhongshan Road, Dalian, China.

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http://doi.wiley.com/10.1002/ijc.31313
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http://dx.doi.org/10.1002/ijc.31313DOI Listing
July 2018

A High-Fat Diet Rich in Saturated and Mono-Unsaturated Fatty Acids Induces Disturbance of Thyroid Lipid Profile and Hypothyroxinemia in Male Rats.

Mol Nutr Food Res 2018 03 28;62(6):e1700599. Epub 2018 Feb 28.

Department of Endocrinology, Shandong Provincial Hospital affiliated to Shandong University, Ji-nan, China.

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http://dx.doi.org/10.1002/mnfr.201700599DOI Listing
March 2018

Controlling electronic properties of MoS/graphene oxide heterojunctions for enhancing photocatalytic performance: the role of oxygen.

Phys Chem Chem Phys 2018 Jan;20(3):1974-1983

School of Science, Hubei University of Technology, Wuhan 430068, China.

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http://dx.doi.org/10.1039/c7cp07303hDOI Listing
January 2018

Identification of related metabolic pathways in prostate cancer.

Oncotarget 2017 Nov 3;8(61):103032-103046. Epub 2017 Oct 3.

CAS Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China.

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http://dx.doi.org/10.18632/oncotarget.21460DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5732708PMC
November 2017

Analyses of gut microbiota and plasma bile acids enable stratification of patients for antidiabetic treatment.

Nat Commun 2017 11 27;8(1):1785. Epub 2017 Nov 27.

Shanghai National Research Centre for Endocrine and Metabolic Diseases, State Key Laboratory of Medical Genomics, Shanghai Institute for Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, 200025, Shanghai, China.

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http://dx.doi.org/10.1038/s41467-017-01682-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5702614PMC
November 2017

Comprehensive Analysis of Short-, Medium-, and Long-Chain Acyl-Coenzyme A by Online Two-Dimensional Liquid Chromatography/Mass Spectrometry.

Anal Chem 2017 12 15;89(23):12902-12908. Epub 2017 Nov 15.

CAS Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences , Dalian 116023, China.

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http://dx.doi.org/10.1021/acs.analchem.7b03659DOI Listing
December 2017

Global Metabolic Profiling Identifies a Pivotal Role of Proline and Hydroxyproline Metabolism in Supporting Hypoxic Response in Hepatocellular Carcinoma.

Clin Cancer Res 2018 01 30;24(2):474-485. Epub 2017 Oct 30.

Scientific Research Center for Translational Medicine, Department of Biotechnology, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, China.

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http://clincancerres.aacrjournals.org/lookup/doi/10.1158/107
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http://dx.doi.org/10.1158/1078-0432.CCR-17-1707DOI Listing
January 2018

An alignment algorithm for LC-MS-based metabolomics dataset assisted by MS/MS information.

Anal Chim Acta 2017 Oct 4;990:96-102. Epub 2017 Aug 4.

CAS Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China.

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http://dx.doi.org/10.1016/j.aca.2017.07.058DOI Listing
October 2017

A Large-scale, multicenter serum metabolite biomarker identification study for the early detection of hepatocellular carcinoma.

Hepatology 2018 02 2;67(2):662-675. Epub 2018 Jan 2.

CAS Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, China.

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http://dx.doi.org/10.1002/hep.29561DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6680350PMC
February 2018

Metabolic changes in primary, secondary, and lipid metabolism in tobacco leaf in response to topping.

Anal Bioanal Chem 2018 Jan 19;410(3):839-851. Epub 2017 Sep 19.

CAS Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, 457 Zhongshan Road, Dalian, Liaoning, 116023, China.

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http://dx.doi.org/10.1007/s00216-017-0596-zDOI Listing
January 2018

Molecular interaction study of flavonoids with human serum albumin using native mass spectrometry and molecular modeling.

Anal Bioanal Chem 2018 Jan 24;410(3):827-837. Epub 2017 Aug 24.

CAS Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, Liaoning, 116023, China.

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http://dx.doi.org/10.1007/s00216-017-0564-7DOI Listing
January 2018

Altered Lipid Metabolism in Recovered SARS Patients Twelve Years after Infection.

Sci Rep 2017 08 22;7(1):9110. Epub 2017 Aug 22.

Key Research Laboratory for Infectious Disease Prevention for State Administration of Traditional Chinese Medicine, Tianjin Institute of Respiratory Diseases, Haihe Clinical College of Tianjin Medical University, Tianjin, China.

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http://dx.doi.org/10.1038/s41598-017-09536-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5567209PMC
August 2017

Plasma metabolomics profiling of maintenance hemodialysis based on capillary electrophoresis - time of flight mass spectrometry.

Sci Rep 2017 08 15;7(1):8150. Epub 2017 Aug 15.

CAS Key Laboratory of Separation Sciences for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, 457 Zhongshan Road, Dalian, 116023, China.

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http://dx.doi.org/10.1038/s41598-017-08327-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5557835PMC
August 2017

Surface-bonded amide-functionalized imidazolium ionic liquid as stationary phase for hydrophilic interaction liquid chromatography.

J Chromatogr A 2018 Jul 12;1559:141-148. Epub 2017 Jul 12.

CAS Key Laboratory of Separation Sciences for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, 116023, China. Electronic address:

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http://dx.doi.org/10.1016/j.chroma.2017.07.037DOI Listing
July 2018

Metabolomics Toward Biomarker Discovery.

Methods Mol Biol 2017 ;1619:467-475

Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, 457 Zhongshan Road, 16023, Dalian, China.

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http://dx.doi.org/10.1007/978-1-4939-7057-5_32DOI Listing
March 2018

Metabolic profiling analysis of Siraitia grosvenorii revealed different characteristics of green fruit and saccharified yellow fruit.

J Pharm Biomed Anal 2017 Oct 20;145:158-168. Epub 2017 Jun 20.

CAS Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China; University of Chinese Academy of Sciences, Beijing 100049, China. Electronic address:

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http://dx.doi.org/10.1016/j.jpba.2017.06.046DOI Listing
October 2017

High-throughput metabolic profiling based on small amount of hepatic cells.

Electrophoresis 2017 09 30;38(18):2296-2303. Epub 2017 May 30.

Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, P. R. China.

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http://dx.doi.org/10.1002/elps.201600539DOI Listing
September 2017

Simultaneous metabolomics and lipidomics analysis based on novel heart-cutting two-dimensional liquid chromatography-mass spectrometry.

Anal Chim Acta 2017 May 20;966:34-40. Epub 2017 Mar 20.

CAS Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China. Electronic address:

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http://dx.doi.org/10.1016/j.aca.2017.03.004DOI Listing
May 2017

Online Three Dimensional Liquid Chromatography/Mass Spectrometry Method for the Separation of Complex Samples.

Anal Chem 2017 02 10;89(3):1433-1438. Epub 2017 Jan 10.

CAS Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences , Dalian 116023, China.

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http://dx.doi.org/10.1021/acs.analchem.6b04401DOI Listing
February 2017

Next-generation transgenic cotton: pyramiding RNAi and Bt counters insect resistance.

Plant Biotechnol J 2017 Sep 16;15(9):1204-1213. Epub 2017 Mar 16.

State Key Laboratory of Plant Genomics and National Center for Plant Gene Research (Beijing), Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, China.

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http://dx.doi.org/10.1111/pbi.12709DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5552478PMC
September 2017

Discovery and validation of potential urinary biomarkers for bladder cancer diagnosis using a pseudotargeted GC-MS metabolomics method.

Oncotarget 2017 Mar;8(13):20719-20728

Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China.

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http://dx.doi.org/10.18632/oncotarget.14988DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5400539PMC
March 2017

Comprehensive investigation of tobacco leaves during natural early senescence via multi-platform metabolomics analyses.

Sci Rep 2016 11 29;6:37976. Epub 2016 Nov 29.

Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China.

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http://dx.doi.org/10.1038/srep37976DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5126694PMC
November 2016

Lysophosphatidylcholines activate PPARδ and protect human skeletal muscle cells from lipotoxicity.

Biochim Biophys Acta 2016 12 30;1861(12 Pt A):1980-1992. Epub 2016 Sep 30.

Division of Pathobiochemistry and Clinical Chemistry, University Tübingen, Otfried-Müller-Strasse 10, 72076 Tübingen, Germany; Institute for Diabetes Research and Metabolic Diseases of the Helmholtz Zentrum München at the University of Tübingen, Otfried-Müller-Strasse 10, 72076 Tübingen, Germany; German Center for Diabetes Research (DZD), Ingolstädter Landstrasse 1, 85764 München-Neuherberg, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.bbalip.2016.09.020DOI Listing
December 2016

Application of LC-MS-based metabolomics method in differentiating septic survivors from non-survivors.

Anal Bioanal Chem 2016 Nov 10;408(27):7641-7649. Epub 2016 Sep 10.

Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, 457 Zhongshan Road, Dalian, Liaoning, 116023, China.

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http://dx.doi.org/10.1007/s00216-016-9845-9DOI Listing
November 2016

High-sensitivity detection of biogenic amines with multiple reaction monitoring in fish based on benzoyl chloride derivatization.

J Chromatogr A 2016 Sep 30;1465:30-7. Epub 2016 Aug 30.

Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China; University of Chinese Academy of Sciences, Beijing 100049, China. Electronic address:

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http://dx.doi.org/10.1016/j.chroma.2016.08.067DOI Listing
September 2016

Nontargeted Screening Method for Illegal Additives Based on Ultrahigh-Performance Liquid Chromatography-High-Resolution Mass Spectrometry.

Anal Chem 2016 09 12;88(17):8870-7. Epub 2016 Aug 12.

Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Science , Dalian 116023, China.

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http://dx.doi.org/10.1021/acs.analchem.6b02482DOI Listing
September 2016