Guosheng Liang

Guosheng Liang

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Guosheng Liang

Guosheng Liang

Publications by authors named "Guosheng Liang"

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Growth hormone acts on liver to stimulate autophagy, support glucose production, and preserve blood glucose in chronically starved mice.

Proc Natl Acad Sci U S A 2019 04 25;116(15):7449-7454. Epub 2019 Mar 25.

Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX 75390.

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http://www.pnas.org/lookup/doi/10.1073/pnas.1901867116
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http://dx.doi.org/10.1073/pnas.1901867116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6462072PMC
April 2019

DHHC4 and DHHC5 Facilitate Fatty Acid Uptake by Palmitoylating and Targeting CD36 to the Plasma Membrane.

Cell Rep 2019 01;26(1):209-221.e5

State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Xiamen University, Xiamen, Fujian, China, 361102. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2018.12.022DOI Listing
January 2019

Developmental and extrahepatic physiological functions of SREBP pathway genes in mice.

Semin Cell Dev Biol 2018 09 20;81:98-109. Epub 2017 Jul 20.

Departments of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX, USA. Electronic address:

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http://dx.doi.org/10.1016/j.semcdb.2017.07.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5775927PMC
September 2018

Interplay between ChREBP and SREBP-1c coordinates postprandial glycolysis and lipogenesis in livers of mice.

J Lipid Res 2018 03 15;59(3):475-487. Epub 2018 Jan 15.

Departments of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX 75390

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http://dx.doi.org/10.1194/jlr.M081836DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5832931PMC
March 2018

Intestinal, but not hepatic, ChREBP is required for fructose tolerance.

JCI Insight 2017 12 21;2(24). Epub 2017 Dec 21.

Division of Endocrinology and Metabolism, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1172/jci.insight.96703DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5752301PMC
December 2017

Cartilage-specific ablation of site-1 protease in mice results in the endoplasmic reticulum entrapment of type IIb procollagen and down-regulation of cholesterol and lipid homeostasis.

PLoS One 2014 22;9(8):e105674. Epub 2014 Aug 22.

Department of Orthopaedic Surgery, Washington University School of Medicine, St. Louis, Missouri, United States of America; Department of Cell Biology and Physiology, Washington University School of Medicine, St. Louis, Missouri, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0105674PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4141819PMC
November 2015

Scap is required for sterol synthesis and crypt growth in intestinal mucosa.

J Lipid Res 2015 Aug 20;56(8):1560-71. Epub 2015 Apr 20.

Department of Molecular Genetics University of Texas Southwestern Medical Center, Dallas, TX 75390-9046 Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390-9046.

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http://dx.doi.org/10.1194/jlr.M059709DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4513997PMC
August 2015

Inflammation. 25-Hydroxycholesterol suppresses interleukin-1-driven inflammation downstream of type I interferon.

Science 2014 Aug;345(6197):679-84

Howard Hughes Medical Institute, Department of Microbiology and Immunology, University of California, San Francisco, CA 94143, USA.

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http://dx.doi.org/10.1126/science.1254790DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4289637PMC
August 2014

Insig proteins mediate feedback inhibition of cholesterol synthesis in the intestine.

J Biol Chem 2014 Jan 11;289(4):2148-56. Epub 2013 Dec 11.

From the Departments of Molecular Genetics and.

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http://dx.doi.org/10.1074/jbc.M113.524041DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3900961PMC
January 2014

The Xbp1s/GalE axis links ER stress to postprandial hepatic metabolism.

J Clin Invest 2013 Jan 21;123(1):455-68. Epub 2012 Dec 21.

Touchstone Diabetes Center, Department of Internal Medicine, UT Southwestern Medical Center, Dallas, Texas 75390, USA.

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http://dx.doi.org/10.1172/JCI62819DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3533268PMC
January 2013

Insulin stimulation of SREBP-1c processing in transgenic rat hepatocytes requires p70 S6-kinase.

Proc Natl Acad Sci U S A 2012 Oct 27;109(40):16184-9. Epub 2012 Aug 27.

Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.

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http://dx.doi.org/10.1073/pnas.1213343109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3479583PMC
October 2012

Blockade of cholesterol absorption by ezetimibe reveals a complex homeostatic network in enterocytes.

J Lipid Res 2012 Jul 22;53(7):1359-68. Epub 2012 Apr 22.

Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX, USA.

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http://dx.doi.org/10.1194/jlr.M027599DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3371247PMC
July 2012

Amino acid substitution in NPC1 that abolishes cholesterol binding reproduces phenotype of complete NPC1 deficiency in mice.

Proc Natl Acad Sci U S A 2011 Sep 6;108(37):15330-5. Epub 2011 Sep 6.

Departments of Molecular Genetics and Pathology, University of Texas Southwestern Medical Center, Dallas, TX 75390-9046, USA.

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http://www.pnas.org/cgi/doi/10.1073/pnas.1112751108
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http://dx.doi.org/10.1073/pnas.1112751108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3174677PMC
September 2011

Ghrelin secretion stimulated by {beta}1-adrenergic receptors in cultured ghrelinoma cells and in fasted mice.

Proc Natl Acad Sci U S A 2010 Sep 16;107(36):15868-73. Epub 2010 Aug 16.

Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, 75390, USA.

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http://www.pnas.org/cgi/doi/10.1073/pnas.1011116107
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http://dx.doi.org/10.1073/pnas.1011116107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2936616PMC
September 2010

Hair growth defects in Insig-deficient mice caused by cholesterol precursor accumulation and reversed by simvastatin.

J Invest Dermatol 2010 May 21;130(5):1237-48. Epub 2010 Jan 21.

Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, Texas, USA.

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http://dx.doi.org/10.1038/jid.2009.442DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2929004PMC
May 2010

LXR-SREBP-1c-phospholipid transfer protein axis controls very low density lipoprotein (VLDL) particle size.

J Biol Chem 2010 Feb 27;285(9):6801-10. Epub 2009 Dec 27.

Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, Texas 75390-9046, USA.

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http://dx.doi.org/10.1074/jbc.M109.079459DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2825474PMC
February 2010

Accelerated fatty acid oxidation in muscle averts fasting-induced hepatic steatosis in SJL/J mice.

J Biol Chem 2009 Sep 6;284(36):24644-52. Epub 2009 Jul 6.

Department of Molecular Genetics, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390-9046, USA.

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http://dx.doi.org/10.1074/jbc.M109.034397DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2782053PMC
September 2009

25-Hydroxycholesterol secreted by macrophages in response to Toll-like receptor activation suppresses immunoglobulin A production.

Proc Natl Acad Sci U S A 2009 Sep 15;106(39):16764-9. Epub 2009 Sep 15.

Department of Molecular Genetics and The Cancer Immunobiology Center, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.

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http://dx.doi.org/10.1073/pnas.0909142106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2757821PMC
September 2009

Identification of the acyltransferase that octanoylates ghrelin, an appetite-stimulating peptide hormone.

Cell 2008 Feb;132(3):387-96

Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.

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http://dx.doi.org/10.1016/j.cell.2008.01.017DOI Listing
February 2008

Severe facial clefting in Insig-deficient mouse embryos caused by sterol accumulation and reversed by lovastatin.

J Clin Invest 2006 Sep;116(9):2356-65

Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, Texas 75390-9046, USA.

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http://dx.doi.org/10.1172/JCI28988DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1555642PMC
September 2006

Schoenheimer effect explained--feedback regulation of cholesterol synthesis in mice mediated by Insig proteins.

J Clin Invest 2005 Sep 11;115(9):2489-98. Epub 2005 Aug 11.

Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, Texas 75390-9046, USA.

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http://www.jci.org/cgi/doi/10.1172/JCI25614
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http://dx.doi.org/10.1172/JCI25614DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1184040PMC
September 2005

Compensatory increase in fatty acid synthesis in adipose tissue of mice with conditional deficiency of SCAP in liver.

Cell Metab 2005 Jan;1(1):41-51

Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA.

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http://dx.doi.org/10.1016/j.cmet.2004.11.004DOI Listing
January 2005

Central role for liver X receptor in insulin-mediated activation of Srebp-1c transcription and stimulation of fatty acid synthesis in liver.

Proc Natl Acad Sci U S A 2004 Aug 20;101(31):11245-50. Epub 2004 Jul 20.

Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX 75390-9046, USA.

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http://dx.doi.org/10.1073/pnas.0404297101DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC509189PMC
August 2004

Deficiency of carbohydrate response element-binding protein (ChREBP) reduces lipogenesis as well as glycolysis.

Proc Natl Acad Sci U S A 2004 May 26;101(19):7281-6. Epub 2004 Apr 26.

Department of Biochemistry, University of Texas Southwestern Medical Center and Dallas Veterans Affairs Medical Center, 4500 South Lancaster Road, Dallas, TX 75216, USA.

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http://www.pnas.org/cgi/doi/10.1073/pnas.0401516101
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http://dx.doi.org/10.1073/pnas.0401516101DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC409910PMC
May 2004

Liver-specific mRNA for Insig-2 down-regulated by insulin: implications for fatty acid synthesis.

Proc Natl Acad Sci U S A 2003 Mar 6;100(6):3155-60. Epub 2003 Mar 6.

Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX 75390-9046, USA.

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http://dx.doi.org/10.1073/pnas.0130116100DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC152262PMC
March 2003

Diminished hepatic response to fasting/refeeding and liver X receptor agonists in mice with selective deficiency of sterol regulatory element-binding protein-1c.

J Biol Chem 2002 Mar 8;277(11):9520-8. Epub 2002 Jan 8.

Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, Texas 75390-9046, USA.

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http://dx.doi.org/10.1074/jbc.M111421200DOI Listing
March 2002