Publications by authors named "Guosheng Li"

89 Publications

Evaluating ZEBRA Battery Module under the Peak-Shaving Duty Cycles.

Materials (Basel) 2021 Apr 28;14(9). Epub 2021 Apr 28.

Battery Materials & System Group, Pacific Northwest National Laboratory, Richland, WA 99352, USA.

With the recent rapid increase in demand for reliable, long-cycle life, and safe battery technologies for large-scale energy-storage applications, a battery module based on ZEBRA battery chemistry is extensively evaluated for its application in peak shaving duty cycles. First, this module is tested with a full capacity cycle consisting of a charging process (factory default) and a discharging process with a current of 40 A. The battery energy efficiency (discharge vs. charge) is about 90%, and the overall energy efficiency is 80.9%, which includes the auxiliary power used to run the battery management system electronics and self-heating to maintain the module operating temperature (265 °C). Generally, because of the increased self-heating during the holding times that exist for the peak shaving duty cycles, the overall module efficiency decreases slightly for the peak-shaving duty cycles (70.7-71.8%) compared to the full-capacity duty cycle. With a 6 h, peak-shaving duty cycle, the overall energy efficiency increases from 71.8% for 7.5 kWh energy utilization to 74.1% for 8.5 kWh. We conducted long-term cycling tests of the module at a 6 h, peak-shaving duty cycle with 7.5 kWh energy utilization, and the module exhibited a capacity degradation rate of 0.0046%/cycle over 150 cycles (>150 days).
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http://dx.doi.org/10.3390/ma14092280DOI Listing
April 2021

Low-dose decitabine modulates T cell homeostasis and restores immune tolerance in immune thrombocytopenia.

Blood 2021 Apr 19. Epub 2021 Apr 19.

Qilu hospital, Cheeloo College of Medicine, Shandong University, Jinan, China.

Our previous clinical study demonstrated that low-dose decitabine showed sustained responses in nearly half of refractory immune thrombocytopenia (ITP) patients. The long-term efficacy of decitabine in ITP is not likely due to its simple role in increasing platelet production. Whether decitabine has the potential to restore immune tolerance in ITP is unknown. In this study, we analyzed the effect of decitabine on T cell subpopulations in ITP in vitro and in vivo. We found that low-dose decitabine promoted the generation and differentiation of regulatory T (Treg) cells, and augmented their immunosuppressive function. Splenocytes from CD61 knockout mice immunized with CD61+ platelets were transferred into severe combined immunodeficient (SCID) mouse recipients to induce a murine model of ITP. Low-dose decitabine alleviated thrombocytopenia and restored the balance between Treg and helper T (Th) cells in active ITP mice. Treg deletion and depletion offset the effect of decitabine in restoring CD4+ T cell subpopulations in ITP mice. For patients who received low-dose decitabine, the quantity and function of Treg cells were substantially improved, whereas Th1 and Th17 cells were suppressed compared with the pretreatment levels. Next-generation RNA sequencing and cytokine analysis showed that low-dose decitabine rebalanced T cell homeostasis, decreased proinflammatory cytokines, and down-regulated phosphorylated STAT3 in ITP patients. STAT3 inhibition analysis suggested that low-dose decitabine might restore Treg cells by inhibiting STAT3 activation. In conclusion, our data indicated that the immunomodulatory effect of decitabine provided one possible mechanistic explanation for the sustained response achieved by low-dose decitabine in ITP.
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http://dx.doi.org/10.1182/blood.2020008477DOI Listing
April 2021

Galectin-9 expression correlates with therapeutic effect in rheumatoid arthritis.

Sci Rep 2021 Mar 10;11(1):5562. Epub 2021 Mar 10.

Department of Rheumatology, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, 250012, Shandong, China.

Galectin-9 (Gal-9) is a multifunctional immunomodulatory factor highly expressed in RA. This study aimed to investigate the expression of Gal-9 and its correlation with disease activity and therapeutic response in RA patients. Active RA patients were enrolled and treated with tacrolimus (TAC) alone or in combination therapy for 12 weeks in a prospective cohort study. Clinical and immunological parameters were recorded at baseline and week 12. We measured Gal-9 expression in different T cell subsets and in plasma. The disease activity of RA patients decreased after treatment. At baseline, the Gal-9 expression percentage was higher in the group with severe disease than in mild or moderate groups. After treatment, the Gal-9 expression in CD3, CD4, CD8 and CD4CD8 cell subsets decreased, as well as Gal-9 mean fluorescence intensity in CD3, CD4 and CD8 T cells. Similarly, plasma Gal-9 levels were lower at week 12 than at baseline. Good responders showed significantly lower Gal-9 expression on CD3 and CD4 T cell subsets and lower plasma Gal-9 levels than poor responders. Gal-9 expression positively correlates with disease activity in RA patients. Gal-9 can be regarded as a new biomarker for evaluating RA activity and therapeutic effect, including TAC.
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http://dx.doi.org/10.1038/s41598-021-85152-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7946964PMC
March 2021

Low-Dose Decitabine Inhibits Cytotoxic T Lymphocytes-Mediated Platelet Destruction Modulating PD-1 Methylation in Immune Thrombocytopenia.

Front Immunol 2021 17;12:630693. Epub 2021 Feb 17.

Department of Hematology, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China.

Cytotoxic T lymphocytes (CTLs)-mediated platelet destruction plays an important role in the pathogenesis of primary immune thrombocytopenia (ITP). The programmed cell death protein 1 (PD-1) signaling can turn off autoreactive T cells and induce peripheral tolerance. Herein, we found that the expression of PD-1 and its ligand PD-L1 on CD8 T cells from ITP patients was decreased. Activating PD-1 pathway by PD-L1-Fc fusion protein inhibited CTLs-mediated platelet destruction in ITP . PD-1 promoter hypermethylation in CD8 T cells was found in ITP patients, resulting in decreased PD-1 expression. The demethylating agent decitabine at a low dose was proved to restore the methylation level and expression of PD-1 on CD8 T cells and reduce the cytotoxicity of CTLs of ITP patients. The phosphorylation levels of phosphatidylinositol 3-kinase (PI3K) and AKT in CD8 T cells were significantly downregulated by low-dose decitabine. Furthermore, blocking PD-1 could counteract the effect of low-dose decitabine on CTLs from ITP patients. Therefore, our data suggest that the aberrant PD-1/PD-L1 pathway is involved in the pathophysiology of ITP and enhancing PD-1/PD-L1 signaling is a promising therapeutic approach for ITP management. Our results reveal the immunomodulatory mechanism of low-dose decitabine in ITP by inhibiting CTLs cytotoxicity to autologous platelets through PD-1 pathway.
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http://dx.doi.org/10.3389/fimmu.2021.630693DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7925841PMC
February 2021

Oxytocin signalling in dendritic cells regulates immune tolerance in the intestine and alleviates DSS-induced colitis.

Clin Sci (Lond) 2021 Feb;135(4):597-611

Department of Physiology, School of Basic Medical Sciences, Cheeloo College of Medicine, Shandong University, Jinan 250012, China.

Background: Ulcerative colitis (UC) is a type of inflammatory bowel disease (IBD) that is associated with immune dysfunction. Recent studies have indicated that the neurosecretory hormone oxytocin (OXT) has been proven to alleviate experimental colitis.

Methods: We investigated the role of OXT/OXT receptor (OXTR) signalling in dendritic cells (DCs) using mice with specific OXTR deletion in CD11c+ cells (OXTRflox/flox×CD11c-cre mice) and a dextran sulfate sodium (DSS)-induced colitis model.

Results: The level of OXT was abnormal in the serum or colon tissue of DSS-induced colitis mice or the plasma of UC patients. Both bone marrow-derived DCs (BMDCs) and lamina propria DCs (LPDCs) express OXTR. Knocking out OXTR in DCs exacerbated DSS-induced acute and chronic colitis in mice. In contrast, the injection of OXT-pretreated DCs significantly ameliorated colitis. Mechanistically, OXT prevented DC maturation through the phosphatidylinositol 4,5-bisphosphate 3-kinase (Pi3K)/AKT pathway and promoted phagocytosis, adhesion and cytokine modulation in DCs. Furthermore, OXT pre-treated DCs prevent CD4+ T cells differentiation to T helper 1 (Th1) and Th17.

Conclusions: Our results suggest that OXT-induced tolerogenic DCs efficiently protect against experimental colitis via Pi3K/AKT pathway. Our work provides evidence that the nervous system participates in the immune regulation of colitis by modulating DCs. Our findings suggest that generating ex vivo DCs pretreated with OXT opens new therapeutic perspectives for the treatment of UC in humans.
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http://dx.doi.org/10.1042/CS20201438DOI Listing
February 2021

Tumor Necrosis Factor-α Blockade Corrects Monocyte/Macrophage Imbalance in Primary Immune Thrombocytopenia.

Thromb Haemost 2021 Jan 14. Epub 2021 Jan 14.

Department of Haematology, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China.

Primary immune thrombocytopenia (ITP) is an acquired autoimmune bleeding disorder. Monocytes and macrophages are the major cells involved in autoantibody-mediated platelet clearance in ITP. In the present study, we found increased percentages of peripheral blood proinflammatory CD16 monocytes and elevated frequencies of splenic tumor necrosis factor-α (TNF-α)-expressing macrophages in ITP patients compared with healthy controls. Concurrently, we observed elevated TNF-α secretion in plasma as well as higher TNF-α mRNA expression in total peripheral blood mononuclear cells and CD14 monocytes of ITP patients. Of note, in vitro TNF-α blockade with neutralizing antibody remarkably reduced polarization to M1 macrophages by inhibiting the nuclear factor kappa B (NF-κB) signaling pathway. Moreover, TNF-α blockade dampened macrophage phagocytosis and T cell stimulatory capacity. Finally, in passive and active murine models of ITP, anti-TNF-α therapy reduced the number of nonclassical monocytes and M1 macrophages, ameliorated the retention of platelets in spleen and liver, and increased the platelet count of ITP mice. Taken together, TNF-α blockade decreased the number and function of proinflammatory subsets of monocytes and macrophages by inhibiting the NF-κB signaling pathway, leading to remarkable attenuation of antibody-mediated platelet destruction. Thus, TNF-α blockade may be a promising therapeutic strategy for the management of ITP.
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http://dx.doi.org/10.1055/s-0040-1722186DOI Listing
January 2021

Multi Cytogenetic Changes in a Patient as Co-Existing MDS and CLL Progresses.

Onco Targets Ther 2021 8;14:177-186. Epub 2021 Jan 8.

Department of Hematology, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, People's Republic of China.

Background: Chronic lymphocytic leukemia (CLL) and myelodysplastic syndrome (MDS) existing simultaneously in untreated patients is extremely rare. There have only been nine cases of untreated CLL concurrent with or followed by the development of MDS. Of all nine cases, four patients exhibited results of cytogenetic phonotypes all showing more than one abnormal chromosome karyotype. It is unknown whether or not these abnormal chromosome karyotypes change during the development of the disease. Meanwhile, the optimal treatment for the concurrence of CLL with MDS has yet to be identified.

Case Presentation: A 69-year-old Chinese man diagnosed with co-existing CLL with MDS was observed from diagnosis, treatment, relapse to death during an admission period of a total of 158 days. Since being diagnosed with CLL and MDS, he was treated by decitabine and his condition went into remission for three months. Four laboratory tests showed an abnormal chromosome cytogenetic karyotype successively changed during the progression of the disease.

Conclusion: It is the first time the abnormal chromosome karyotype variation significantly associated with the change of the illness was discovered. In the relapse and deterioration stages of the disease, there was t(9;22)(q24; q11.2); add(11)(p15) and other chromosome translocation. Repeated occurrence of TET2 mutation is special at this stage of the disease. Furthermore, decitabine could be beneficial for the treatment of the disease.
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http://dx.doi.org/10.2147/OTT.S281800DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7802771PMC
January 2021

Radiomic signature based on CT imaging to distinguish invasive adenocarcinoma from minimally invasive adenocarcinoma in pure ground-glass nodules with pleural contact.

Cancer Imaging 2021 Jan 6;21(1). Epub 2021 Jan 6.

Department of Radiology, The First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning Province, People's Republic of China.

Background: Pure ground-glass nodules (pGGNs) with pleural contact (P-pGGNs) comprise not only invasive adenocarcinoma (IAC), but also minimally invasive adenocarcinoma (MIA). Radiomics recognizes complex patterns in imaging data by extracting high-throughput features of intra-tumor heterogeneity in a non-invasive manner. In this study, we sought to develop and validate a radiomics signature to identify IAC and MIA presented as P-pGGNs.

Methods: In total, 100 patients with P-pGGNs (69 training samples and 31 testing samples) were retrospectively enrolled from December 2012 to May 2018. Imaging and clinical findings were also analyzed. In total, 106 radiomics features were extracted from the 3D region of interest (ROI) using computed tomography (CT) imaging. Univariate analyses were used to identify independent risk factors for IAC. The least absolute shrinkage and selection operator (LASSO) method with 10-fold cross-validation was used to generate predictive features to build a radiomics signature. Receiver-operator characteristic (ROC) curves and calibration curves were used to evaluate the predictive accuracy of the radiomics signature. Decision curve analyses (DCA) were also conducted to evaluate whether the radiomics signature was sufficiently robust for clinical practice.

Results: Univariate analysis showed significant differences between MIA (N = 47) and IAC (N = 53) groups in terms of patient age, lobulation signs, spiculate margins, tumor size, CT values and relative CT values (all P < 0.05). ROC curve analysis showed, when MIA was identified from IAC, that the critical value of tumor length diameter (TLD) was1.39 cm and the area under the ROC curve (AUC) was 0.724 (sensitivity = 0.792, specificity = 0.553). The critical CT value on the largest axial plane (CT-LAP) was - 597.45 HU, and the AUC was 0.666 (sensitivity = 0.698, specificity= 0.638). The radiomics signature consisted of seven features and exhibited a good discriminative performance between IAC and MIA, with an AUC of 0.892 (sensitivity = 0.811, specificity 0.719), and 0.862 (sensitivity = 0.625, specificity = 0.800) in training and testing samples, respectively.

Conclusions: Our radiomics signature exhibited good discriminative performance in differentiating IAC from MIA in P-pGGNs, and may offer a crucial reference point for follow-up and selective surgical management.
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http://dx.doi.org/10.1186/s40644-020-00376-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7788838PMC
January 2021

Reduced intracellular antioxidant capacity in platelets contributes to primary immune thrombocytopenia via ROS-NLRP3-caspase-1 pathway.

Thromb Res 2021 03 16;199:1-9. Epub 2020 Dec 16.

Department of Hematology, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China; Shandong Provincial Key Laboratory of Immunohematology, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China. Electronic address:

Primary immune thrombocytopenia (ITP) is a common acquired autoimmune hemorrhagic disease characterized by a low platelet count and increased risk of bleeding. However, some patients do not respond well to current therapeutic approaches. Further studies on pathogenesis and pathophysiology of ITP are needed to discover new therapeutic targets. We explored the role of enhanced intracellular oxidative stress and NLRP3 inflammasome activation of platelets in ITP. The expression of NLRP3 inflammasome was assessed in platelets from active ITP patients and healthy donors. Both the mRNA and protein expression level of platelet NLRP3 inflammasome was upregulated in ITP patients compared with healthy donors. Besides, the elevated caspase-1 activity and increased co-localization of NLRP3 and its adaptor molecule ASC indicated activation of NLRP3 inflammasome in ITP platelets. Significantly decreased intracellular antioxidant capacity was observed in ITP platelets. HO supplementation elevated the expression of NLRP3 inflammasome and increased IL-1β secretion in ITP platelets. Preincubating ITP platelets with NAC down-regulated the expression of NLRP3 inflammasome. Pretreating ITP platelets with NLRP3 inhibitor MCC950 or caspase-1 inhibitor Z-YVAD-FMK significantly reduced the proportion of pyroptotic cells in HO-treated ITP platelets and suppressed IL-1β secretion in supernatants. Hence, platelet NLRP3 inflammasome activation resulted from reduced intracellular antioxidant capacity plays a critical role in ITP and might have potential diagnostic or therapeutic implications.
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http://dx.doi.org/10.1016/j.thromres.2020.12.008DOI Listing
March 2021

High performance sodium-sulfur batteries at low temperature enabled by superior molten Na wettability.

Chem Commun (Camb) 2021 Jan;57(1):45-48

Electrochemical Materials and Systems Group, Pacific Northwest National Laboratory, Richland, WA 99352, USA.

Reducing the operating temperature of conventional molten sodium-sulfur batteries (∼350 °C) is critical to create safe and cost-effective large-scale storage devices. By raising the surface treatment temperature of lead acetate trihydrate, the sodium wettability on β''-Al2O3 improved significantly at 120 °C. The low temperature Na-S cell can reach a capacity as high as 520.2 mA h g-1 and stable cycling over 1000 cycles.
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http://dx.doi.org/10.1039/d0cc06987fDOI Listing
January 2021

NLRP3 inflammasome upregulates PD-L1 expression and contributes to immune suppression in lymphoma.

Cancer Lett 2021 01 19;497:178-189. Epub 2020 Oct 19.

Department of Hematology, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, 250012, PR China. Electronic address:

The NLRP3 inflammasome plays a pro-tumorigenic role in various malignancies. However, its potential role in lymphomagenesis remains unclear. In this study, we identified an immunosuppressive state in patients with diffuse large B cell lymphoma (DLBCL), which was characterized by markedly elevated interleukin (IL)-18 levels in lymphoma tissues and positive correlation with programmed death ligand 1 (PD-L1) expression. Furthermore, NLRP3 inflammasome activation in DLBCL cell lines upregulated PD-L1 and reduced the proportion of cytotoxic T cells. NLRP3 inflammasome blockade in vivo suppressed lymphoma growth and ameliorated anti-tumor immunity by downregulating PD-L1 in the tumor microenvironment and decreasing the proportion of PD-1/TIM-3-expressing T cells, myeloid-derived suppressor cells, tumor-associated macrophages, and regulatory T cells. Further in vivo studies revealed IL-18 as the main effector cytokine involved in the negative regulation of anti-lymphoma immunity. Interestingly, NLRP3 blockers combined with anti-PD-L1 treatment exerted antagonistic effects during lymphoma therapy. Altogether, our findings indicate that NLRP3 inflammasome promotes immunosuppression by modulating PD-L1 and immune cells. Accordingly, this study highlights the prognostic and therapeutic values of the NLRP3 inflammasome in lymphoma.
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http://dx.doi.org/10.1016/j.canlet.2020.10.024DOI Listing
January 2021

Levels and Clinical Significance of Regulatory B Cells and T Cells in Acute Myeloid Leukemia.

Biomed Res Int 2020 6;2020:7023168. Epub 2020 Oct 6.

Department of Hematology, Qilu Hospital, Shandong University, Jinan 250012, China.

Acute myeloid leukemia (AML) is a heterogeneous hematological malignancy, whose immunological mechanisms are still partially uncovered. Regulatory B cells (Bregs) and CD4+ regulatory T cells (Tregs) are subgroups of immunoregulatory cells involved in modulating autoimmunity, inflammation, and transplantation reactions. Herein, by studying the number and function of Breg and Treg cell subsets in patients with AML, we explored their potential role in the pathogenesis of AML. Newly diagnosed AML patients, AML patients in complete remission, and healthy controls were enrolled. Flow cytometry was used to detect percentages of Bregs and Tregs. ELISA was conducted to detect IL-10 and TGF- in plasma. The mRNA levels of IL-10 and Foxp3 were measured with RT-qPCR. The relationship of Bregs and Tregs with the clinicopathological parameters was analyzed. There was a significant reduction in the frequencies of Bregs and an increase of Tregs in newly diagnosed AML patients compared with healthy controls. Meanwhile, patients in complete remission exhibited levels of Bregs and Tregs comparable to healthy controls. Furthermore, compared with healthy controls and AML patients in complete remission, newly diagnosed AML patients had increased plasma IL-10 but reduced TGF-. IL-10 and Foxp3 mRNA levels were upregulated in the newly diagnosed AML patients. However, there were no significant differences in IL-10 and Foxp3 mRNA levels between patients in complete remission and healthy controls. Bregs and Tregs have abnormal distribution in AML patients, suggesting that they might play an important role in regulating immune responses in AML.
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http://dx.doi.org/10.1155/2020/7023168DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7557919PMC
May 2021

Asymmetric Acceptor-Donor-Acceptor Polymers with Fast Charge Carrier Transfer for Solar Hydrogen Production.

Chemistry 2021 Jan 15;27(3):939-943. Epub 2020 Dec 15.

State Key Laboratory of Photocatalysis on Energy and Environment, and, Key Laboratory of Molecule Synthesis and Function Discovery, College of Chemistry, Fuzhou University, Fuzhou, 350116, P. R. China.

Construction of local donor-acceptor architecture is one of the valid means for facilitating the intramolecular charge transfer in organic semiconductors. To further accelerate the interface charge transfer, a ternary acceptor-donor-acceptor (A -D-A ) molecular junction is established via gradient nitrogen substituting into the polymer skeleton. Accordingly, the exciton splitting and interface charge transfer could be promptly liberated because of the strong attracting ability of the two different electron acceptors. Both DFT calculations and photoluminescence spectra elucidate the swift charge transfer at the donor-acceptor interface. Consequently, the optimum polymer, N -CP, undergoes a remarkable photocatalytic property in terms of hydrogen production with AQY =26.6 % by the rational design of asymmetric molecular junctions on organic semiconductors.
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http://dx.doi.org/10.1002/chem.202003856DOI Listing
January 2021

Elastic NaMoS-Carbon-BASE Triple Interface Direct Robust Solid-Solid Interface for All-Solid-State Na-S Batteries.

Nano Lett 2020 Sep 27;20(9):6837-6844. Epub 2020 Aug 27.

Department of Chemistry and Biochemistry, Northern Illinois University, DeKalb, Illinois 60115. United States.

The developments of all-solid-state sodium batteries are severely constrained by poor Na-ion transport across incompatible solid-solid interfaces. We demonstrate here a triple NaMoS-carbon-BASE nanojunction interface strategy to address this challenge using the β″-AlO solid electrolyte (BASE). Such an interface was constructed by adhering ternary Na electrodes containing 3 wt % MoS and 3 wt % carbon on BASE and reducing contact angles of molten Na to ∼45°. The ternary Na electrodes exhibited twice improved elasticity for flexible deformation and intimate solid contact, whereas NaMoS and carbon synergistically provide durable ionic/electronic diffusion paths, which effectively resist premature interface failure due to loss of contact and improved Na stripping utilization to over 90%. Na metal hosted via triple junctions exhibited much smaller charge-transfer resistance and 200 h of stable cycling. The novel interface architecture enabled 1100 mAh/g cycling of all-solid-state Na-S batteries when using advanced sulfur cathodes with Na-ion conductive PEO-NaFSI binder and NaMoS redox catalytic mediator.
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http://dx.doi.org/10.1021/acs.nanolett.0c02871DOI Listing
September 2020

Heavy metal pollution and the risk from tidal flat reclamation in coastal areas of Jiangsu, China.

Mar Pollut Bull 2020 Sep 3;158:111427. Epub 2020 Jul 3.

Key Laboratory of Land Surface Pattern and Simulation, Institute of Geographical Sciences and Natural Resources Research, Chinese Academy of Sciences, Beijing 100101, China.

Tidal flat is an important supplementary land resource. However, increasing tidal flat reclamation in China has resulted in severe environmental issues. Using single-metal pollution index and multi-metal Nemerow pollution index, this study aimed to evaluate the risks of heavy metal pollution among different tidal flat use types, including fish farm, farmland, pastoral land, industrial land, forest and unutilized land. The results indicated that, concentrations of all elements were higher than geochemical values; Cd posed the highest risk, followed by As and Ni. Fish farm created the highest risk, followed by farmland. Every one year increase in fish farming led to increases in sediment concentrations of Cu, Cr, Ni, Pb, Zn and As by 0.73, 1.25, 0.68, 0.41, 1.22 and 0.20 mg.kg, respectively. Tidal flat reclamation in Jiangsu Province creates the risk of heavy metal pollution, and specific attention should be paid to the fodders and additives used in fish farming.
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http://dx.doi.org/10.1016/j.marpolbul.2020.111427DOI Listing
September 2020

Myeloid-Derived Suppressor Cells and γδT17 Cells Contribute to the Development of Gastric MALT Lymphoma in -Infected Mice.

Front Immunol 2019 28;10:3104. Epub 2020 Jan 28.

Department of Hematology, Qilu Hospital of Shandong University, Jinan, China.

-induced chronic inflammation and immune disorders are closely associated with the development of gastric mucosa-associated lymphoid tissue (MALT) lymphoma. Myeloid-derived suppressor cells (MDSCs) exhibit strong immunosuppressive properties and promote the growth of various solid tumors. However, the role of MDSCs in the development of MALT lymphoma has not been elucidated so far. We detected significant infiltration and enrichment of MDSCs in patients with MALT lymphoma, as well in -infected mouse model of gastric MALT lymphoma. In addition, the expression of arginase-1 and inducible nitric oxide synthase was significantly elevated both in gastric MALT lymphoma tissues and -infected stomach. Persistent infection closely reproduced the development of gastric MALT lymphoma and was accompanied by increased numbers of γδT17 cells. Accumulation of γδT17 cells was also validated in the human gastric MALT lymphoma tissues. Furthermore, the elevated cytokines interleukin-23 and interleukin-1β, as well as chemokines CCL20/CCR6, may be involved in the accumulation of γδT17 cells and the subsequent immunosuppression. These findings highlight the role of MDSCs and γδT17 cells in immune dysregulation during gastric MALT lymphoma development and their potential as therapeutic targets.
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http://dx.doi.org/10.3389/fimmu.2019.03104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6998799PMC
November 2020

Supramolecular Alternating Donor-Acceptor Assembly toward Intercalated Covalent Organic Frameworks.

J Am Chem Soc 2020 Feb 13;142(8):3712-3717. Epub 2020 Feb 13.

Department of Chemistry, College of Chemistry and Chemical Engineering , Xiamen University , Xiamen 361005 , P. R. China.

Conventionally, -direction modulation of two-dimensional covalent organic frameworks (2D-COFs) is difficult to achieve because they rely on spontaneous π-π interactions to form 3D architectures. Herein, we report a facile construction of a novel intercalated covalent organic framework (Intercalated-COF) by synchronizing operations of supramolecular donor-acceptor (D-A) interactions (A unit: 2,5,8,11-tetra(-formylphenyl)-perylene diimide (PDI) ; D unit: perylene , as intercalator) in the vertical directions, with polymerizations (by only reacting with -phenylenediamine ) in the lateral directions. In this Intercalated-COF, the PDI-based covalent 2D layers are uniformly separated by perylene guest layers. This supramolecular strategy opens the possibility for -direction modulation of 2D-COFs through "intercalating" various guest molecules and thus may contribute to the exploration of advanced applications of these porous and crystalline frameworks.
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http://dx.doi.org/10.1021/jacs.9b13559DOI Listing
February 2020

Corrigendum: Qualitative and Quantitative NAD Metabolomics Lead to Discovery of Multiple Functional Nicotinate -Glycosyltransferase In .

Front Plant Sci 2019;10:1648. Epub 2020 Jan 8.

State Key Laboratory of Plant Genomics and National Center for Plant Gene Research (Beijing), Institute of Genetics and Developmental Biology, The Innovative Academy of Seed Design, Chinese Academy of Sciences, Beijing, China.

[This corrects the article DOI: 10.3389/fpls.2019.01164.].
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http://dx.doi.org/10.3389/fpls.2019.01648DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6960205PMC
January 2020

Expression of Galectin-9 and correlation with disease activity and vascular endothelial growth factor in rheumatoid arthritis.

Clin Exp Rheumatol 2020 Jul-Aug;38(4):654-661. Epub 2019 Nov 16.

Department of Rheumatology, Qilu Hospital of Shandong University, Ji'nan, Shandong, and Shenzhen Research Institute of Shandong University, Shenzhen, Guangdong, China.

Objectives: Despite the important role of Galectin-9 (Gal-9) in inflammation and angiogenesis, only a few studies on Galectin-9 expression have been performed in rheumatoid arthritis (RA) patients. The present study aimed to identify the concentration of Galectin-9 in plasma, its expression in peripheral blood T cell subsets in RA patients, and the association between Galectin-9 and vascular endothelial growth factor (VEGF) in RA.

Methods: One hundred and five active RA patients and 52 age- and sex-matched healthy controls (HCs) were enrolled in the study. Gal-9, vascular endothelial growth factor (VEGF), and tumour necrosis factor (TNF)-α level in plasma were determined by ELISA. The intracellular positive expression rates and medium fluorescence intensity (MFI) of Gal-9 and VEGF in T cell subsets, were examined by flow cytometry.

Results: Plasma Gal-9, TNF-α, and VEGF levels were higher in the RA group than in the HCs group. The plasma Gal-9 level positively correlated with Gal-9 expression in the total lymphocyte and CD3+ T cell, CRP, SDAI, and CDAI of RA patients. The Gal-9 expressions in the cytoplasm of CD4+ T, CD8+ T, Treg, and DNT cells positively correlated with plasma TNF-α levels in RA patients. The Gal-9 expressions in CD4+ T and CD8+ T subsets also positively correlated with plasma VEGF levels. The plasma VEGF levels and VEGF expressions in CD4+ T, CD8+ T, and Treg subsets positively correlated with SDAI and CRP in RA patients.

Conclusions: Gal-9 can be a potential biomarker for RA disease activity. Gal-9 is probably associated with angiogenesis processing in RA.
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September 2020

Qualitative and Quantitative NAD Metabolomics Lead to Discovery of Multiple Functional Nicotinate -Glycosyltransferase in .

Front Plant Sci 2019 27;10:1164. Epub 2019 Sep 27.

State Key Laboratory of Plant Genomics and National Center for Plant Gene Research (Beijing), Institute of Genetics and Developmental Biology, The Innovative Academy of Seed Design, Chinese Academy of Sciences, Beijing, China.

The Preiss-Handler pathway, which salvages nicotinate (NA) for NAD synthesis, is a conserved biochemical pathway in land plants. We previously demonstrated that various NA conjugations (mainly methylation and glycosylation) shared the NA detoxification function in all tested plants. It remains unclear whether other NA conjugates with low abundance exist in plants. In this study, we discovered at least two additional NA -glycosides in , which was tentatively elucidated as nicotinate -pentoside (NaP) and NA -rhamoside (NaRha), using liquid chromatography triple-quadrupole mass spectrometry (LC-QQQ-MS) with precursor ion-scanning (PreIS). We further quantitatively profile the NAD-related metabolites in 24 tissues of . Biochemical assays of UGT76C family revealed that UGT76C5 (encoded by , previously identified as NaGT) was a multiple functional nicotinate -glycosyltransferase, with high preference to UDP-xylose and UDP-arabinose. The deficiency of NaP and NaRha in mutant suggested that UGT76C5 is responsible for biosynthesis of NaP and NaRha . We also identify one amino acid difference in PSPG (plant secondary product glycosyltransferase) motif is responsible for the divergence of NaGT (UGT76C4) and UGT76C5. Taken together, our study not only identifies a novel nicotinate -glycosyltransferase but also paves the way for investigations of the physiological functions of various NA conjugations.
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http://dx.doi.org/10.3389/fpls.2019.01164DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6776627PMC
September 2019

Interleukin-37 reduces inflammation and impairs phagocytosis of platelets in immune thrombocytopenia (ITP).

Cytokine 2020 01 23;125:154853. Epub 2019 Sep 23.

Department of Hematology, Qilu Hospital, Shandong University, Jinan, China; Shandong Provincial Key Laboratory of Immunohematology, Qilu Hospital, Shandong University, Jinan, China. Electronic address:

Immune thrombocytopenia (ITP) is an autoimmune disease characterized by low platelet count with heterogeneous bleeding manifestations. Severe bleeding in ITP is not completely related with low platelet count. Fcγ receptor (FcγR)-mediated platelet destruction is one of the major mechanisms of ITP. Interleukin-37 (IL-37) is a fundamental natural suppressor of innate immunity and inflammatory responses in several autoimmune diseases. However, the role of IL-37 in the pathogenesis of ITP is unknown. In the present study, we identified that IL-37 expression was elevated in ITP patients, which was correlated with platelet count and the severity of bleeding in ITP, indicating that IL-37 could be a candidate in evaluating disease severity of ITP. In the in vitro study, IL-37 initiated an anti-inflammatory effect on monocytes/macrophages from ITP patients by down-regulating the phosphorylation of MAPK, AKT, and NF-κB signaling pathways. Moreover, IL-37 restored the balance of activating and inhibitory FcγRs and decreased antibody-mediated platelet phagocytosis by monocytes/macrophages. Our findings suggest that IL-37 may be a promising indicator of the disease severity and supplementation of IL-37 may be therapeutically beneficial for ITP patients.
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http://dx.doi.org/10.1016/j.cyto.2019.154853DOI Listing
January 2020

An Intermediate-Temperature High-Performance Na-ZnCl Battery.

ACS Omega 2018 Nov 16;3(11):15702-15708. Epub 2018 Nov 16.

Electrochemical Materials and Systems Group, Pacific Northwest National Laboratory, Richland, Washington 99352, United States.

The Na-β-alumina battery (NBB) is one of the most promising energy storage technologies for integrating renewable energy resources into the grid. In the family of NBBs, Na-NiCl battery has been extensively studied during the past decade because it has a lower operating temperature, better safety, and good battery performance. One of the major issues with the Na-NiCl battery is material cost, which is primarily from Ni metal in the battery cathode. As an alternative, Zn is much cheaper than Ni, and replacing Ni with Zn in the cathode can significantly reduce the cost. In this work, we investigate the performance and reaction mechanism for a Na-ZnCl battery at 190 °C. Two-step reversible reactions are identified. During the first step of charging, NaCl reacts with Zn to produce a ribbon-type NaZnCl layer. This layer is formed at the NaCl-Zn interface rather than covering the surface of the Zn particles, which leads to an excellent cell rate capability. During the second step, the produced NaZnCl is gradually consumed to form ZnCl on the surface of Zn particles. The formed ZnCl covers most of the surface area of the Zn particles and shows a limited rate capability compared to that of the first step. We conclude that this limited performance of the second step is due to the passivation of Zn particles by ZnCl, which blocks the electron pathway of the NaCl-Zn cathodes.
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http://dx.doi.org/10.1021/acsomega.8b02112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6644324PMC
November 2018

Humic Acid Fertilizer Improved Soil Properties and Soil Microbial Diversity of Continuous Cropping Peanut: A Three-Year Experiment.

Sci Rep 2019 08 19;9(1):12014. Epub 2019 Aug 19.

Institute of Agricultural Resources and Environment, Shandong Academy of Agricultural Sciences, Ji'nan, 250100, China.

Although humic acid has been demonstrated to improve the quality of some soil types, the long-term effects of humic acid on soil under continuous cropping peanut are not fully understood. This study aimed to investigate the continuous effects of humic acid on the physicochemical properties, microbial diversity, and enzyme activities of soil under continuous cropping peanut. In this study, a three-year consecutive experiment of cropping peanut was conducted in the North China Plain. In addition to the equal nitrogen, phosphorus, and potassium inputs, humic acid treatment was applied with inorganic fertilizers. Compared with control experiments, humic acid increased the yield and quality of continuous cropping peanut. To elucidate the mechanism of humic acid affecting the soil quality, various soil quality indicators were evaluated and compared in this study. It was found that humic acid increased soil nutrient contents, including the total soil nitrogen, total phosphorus, total potassium, available nitrogen, available phosphorus, available potassium, and organic matter contents, which exhibited the maximum effect in the third year. Meanwhile, the urease, sucrase, and phosphatase activities in the soil significantly increased after treated with humic acid, of which the maturity period increased most significantly. The same results were observed for three consecutive years. Microbial diversity varied considerably according to the high throughput sequencing analysis. Specifically, the number of bacteria decreased while that of fungi increased after humic acid treatment. The abundance of Firmicutes in bacteria, Basidiomycota, and Mortierellomycota in fungi all increased, which have been reported as being beneficial to plant growth. In contrast, the abundance of Ascomycota in fungi was reduced, and most of the related genera identified are pathogenic to plants. In conclusion, humic acid improved the yield and quality of continuous cropping peanut because of improved physicochemical properties, enzymatic activities, and microbial diversity of soil, which is beneficial for alleviating the obstacles of continuous cropping peanut.
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http://dx.doi.org/10.1038/s41598-019-48620-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6700118PMC
August 2019

Cs and Pu in the Bohai Sea of China: Comparison in distribution and source identification between the inner bay and the tidal flat.

Mar Pollut Bull 2019 Jan 17;138:604-617. Epub 2018 Dec 17.

State Key Laboratory of Radiation Medicine and Protection, School for Radiological and Interdisciplinary Sciences (RAD-X), Collaborative Innovation Center of Radiological Medicine of Jiangsu Higher Education Institutions and School of Radiation Medicine and Protection, Soochow University, Suzhou 215123, China. Electronic address:

We investigated artificial radionuclides (Pu and Cs) in surface sediments and sediment cores collected from the Bohai Bay and the tidal flat of the Liaodong Bay, China. Increasing trends for Pu activities and Pu/Pu atom ratios (˃0.18) were observed from land to sea and from north to south in the Bohai Bay. This spatial pattern implied that the scavenging process between riverine sediments and Pacific Proving Ground (PPG) source Pu transported by the currents such as Yellow Sea Warm Current had occurred in the Bohai Bay. In contrast, relatively lower Pu/Pu atom ratios in the tidal flat of Liaodong Bay were due to the mixing process between more global out and less PPG source Pu. The riverine Pu contributions to the total global fallout Pu in the Haihe River (32.8%) were much lower than those in the Yangtze River estuary (77%-80%), indicating better soil conservation in the Haihe River Catchment.
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http://dx.doi.org/10.1016/j.marpolbul.2018.12.005DOI Listing
January 2019

Tailoring the Grain Boundary Chemistry of Polymeric Carbon Nitride for Enhanced Solar Hydrogen Production and CO Reduction.

Angew Chem Int Ed Engl 2019 Mar 12;58(11):3433-3437. Epub 2019 Feb 12.

State Key Laboratory of Photocatalysis on Energy and Environment, College of Chemistry, Fuzhou University, Fuzhou, 350116, China.

Photocatalytic water splitting is a promising and clean way to mimic plant photosynthesis in a sustainable manner. Improvements of the quantum efficiency and optical absorption in the relevant range are necessary steps to approach practicality. Herein, we reported that these issues can be readily addressed when 5-aminotetrazole, a monomer with high nitrogen content, is used for the synthesis of carbon nitride. The molten salt mixture NaCl/KCl is used as a high-temperature solvent to tailor the grain boundary structure and chemistry. Visible light quantum efficiency for H production of 0.65 could be obtained in the presence of K HPO as a double layer modifier. This value is very high, considering that this number depends on light to charge couple conversion, charge localization, as well as a successful oxidation and reduction reaction.
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http://dx.doi.org/10.1002/anie.201811938DOI Listing
March 2019

Bismuth Islands for Low-Temperature Sodium-Beta Alumina Batteries.

ACS Appl Mater Interfaces 2019 Jan 8;11(3):2917-2924. Epub 2019 Jan 8.

Department of Materials Science and Engineering , Yonsei University , Seoul 03722 , Korea.

Wetting of the liquid metal on the solid electrolyte of a liquid metal battery controls the operating temperature and performance of the battery. Liquid sodium electrodes are particularly attractive because of their low cost, natural abundance, and geological distribution. However, they wet poorly on a solid electrolyte near its melting temperature, limiting their widespread suitability for low-temperature batteries to be used for large-scale energy storage systems. Herein, we develop an isolated metal-island strategy that can improve sodium wetting in sodium-beta alumina batteries that allows operation at lower temperatures. Our results suggest that in situ heat treatment of a solid electrolyte followed by bismuth deposition effectively eliminates oxygen and moisture from the surface of the solid electrolyte, preventing the formation of an oxide layer on the liquid sodium, leading to enhanced wetting. We also show that employing isolated bismuth islands significantly improves cell performance, with cells retaining 94% of their charge after the initial cycle, an improvement over cells without bismuth islands. These results suggest that coating isolated metal islands is a promising and straightforward strategy for the development of low-temperature sodium-β alumina batteries.
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http://dx.doi.org/10.1021/acsami.8b13954DOI Listing
January 2019

Effect of recombinant human thrombopoietin on immune thrombocytopenia in pregnancy in a murine model.

Int Immunopharmacol 2019 Feb 17;67:287-293. Epub 2018 Dec 17.

Department of Hematology, Qilu Hospital, Shandong University, Jinan, China; Shandong Provincial Key Laboratory of Immunohematology, Qilu Hospital, Shandong University, Jinan, China; Leading Research Group of Scientific Innovation, Department of Science and Technology of Shandong Province, Qilu Hospital, Shandong University, Jinan, China. Electronic address:

Primary immune thrombocytopenia (ITP) is a serious medical disorder that has the potential for maternal and fetal mortality. Corticosteroids, intravenous immunoglobulin, or both are the first-line treatments for ITP in pregnancy, but choices are limited if patients fail to respond. Recombinant human thrombopoietin (rhTPO) has been proved effective and safe in management of chronic ITP. However, the efficacy and safety of rhTPO for pregnant ITP patients still need to be explored. Here we developed an ideal murine model that simulated human ITP in pregnancy and evaluated the efficacy and safety of rhTPO in management of ITP in pregnancy. Model mice were subcutaneously administered with 0, 150, 1,500 and 15,000 U/kg rhTPO for 14 days. Significant higher platelet counts were noted in rhTPO-treated groups on Day 7, 10 and 14. On Day 20, half the maternal mice were sacrificed. Frequencies of Tregs in CD4 T cells in rhTPO-treated groups were statistically higher than control. Significant higher plasma levels of TGF-β1 were observed in rhTPO-treated groups than control. There was no significant abnormality in gross or visceral examination of fetuses. The remaining half maternal mice and their pups were observed for at least three weeks to assess vital signs. No abnormal signs were noted. Furthermore, we investigated the underlying mechanisms. Results showed that Tregs were negative for c-Mpl and rhTPO had no direct effect on Tregs. Additionally, the Treg frequency in splenic CD4 T cells in LY2109761-treated model mice was statistically lower than control. Thus, rhTPO may be a safe and effective option for treatment of pregnant ITP patients.
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http://dx.doi.org/10.1016/j.intimp.2018.12.032DOI Listing
February 2019

Opaque-2 Regulates a Complex Gene Network Associated with Cell Differentiation and Storage Functions of Maize Endosperm.

Plant Cell 2018 10 27;30(10):2425-2446. Epub 2018 Sep 27.

School of Plant Sciences, University of Arizona, Tucson, Arizona 85721

Development of the cereal endosperm involves cell differentiation processes that enable nutrient uptake from the maternal plant, accumulation of storage products, and their utilization during germination. However, little is known about the regulatory mechanisms that link cell differentiation processes with those controlling storage product synthesis and deposition, including the activation of zein genes by the maize () bZIP transcription factor Opaque-2 (O2). Here, we mapped in vivo binding sites of O2 in B73 endosperm and compared the results with genes differentially expressed in B73 and B73 We identified 186 putative direct O2 targets and 1677 indirect targets, encoding a broad set of gene functionalities. Examination of the temporal expression patterns of O2 targets revealed at least two distinct modes of O2-mediated gene activation. Two O2-activated genes, and (), encode transcription factors, which can in turn coactivate other O2 network genes with O2. NKD2 (with its paralog NKD1) was previously shown to be involved in regulation of aleurone development. Collectively, our results provide insights into the complexity of the O2-regulated network and its role in regulation of endosperm cell differentiation and function.
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http://dx.doi.org/10.1105/tpc.18.00392DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6241275PMC
October 2018

Proteasome Inhibition with Bortezomib Induces Apoptosis of Long-Lived Plasma Cells in Steroid-Resistant or Relapsed Immune Thrombocytopaenia.

Thromb Haemost 2018 Oct 20;118(10):1752-1764. Epub 2018 Sep 20.

Department of Haematology, Qilu Hospital, Shandong University, Jinan, China.

Primary immune thrombocytopaenia (ITP) is the most common haemorrhagic disease. Although most patients respond initially to mainstream therapies, such as corticosteroids, immunosuppressants or rituximab, a large proportion of patients fail to respond or relapse. These treatments only affect B lymphocytes or short-lived plasma cells, but not already existing long-lived plasma cells (LLPCs) which persistently secrete antibodies. We hypothesized that LLPCs may play a role in the corticosteroid-resistant or relapsed ITP patients, and bortezomib, a proteasome inhibitor, may act on plasma cells and offer a therapeutic effect. Although a significant difference in the proportion of CD19CD38CD138 total LLPCs was not observed by flow cytometry, a glycoprotein (GP) IIb/IIIa-specific enzyme-linked immunosorbent spot (ELISpot) assay of sorted CD19CD138 LLPCs confirmed the existence of anti-platelet antibody-secreting LLPCs in ITP patients in contrast to healthy controls. Moreover, the LLPCs could be eliminated in the presence of bortezomib by ELISpot assay, which was also confirmed by flow cytometry. Accordingly, a modified monoclonal antibody immobilization of platelet antigen assay of sorted CD19CD138 LLPCs revealed that the concentration of anti-platelet antibodies decreased remarkably when cultured with 0.25 ng/mL bortezomib for 5 days. The apoptosis assay demonstrated that bortezomib could induce apoptosis of LLPCs in a concentration-dependent manner. The proteasome activity assay showed that bortezomib significantly reduced the proteasome activity in sorted CD19CD138 LLPCs. Furthermore, in active ITP murine models, bortezomib eliminated LLPCs in vivo and alleviated thrombocytopaenia. We conclude that LLPCs participate in the pathogenesis of ITP and bortezomib may have potential as a novel therapeutic regimen.
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http://dx.doi.org/10.1055/s-0038-1669921DOI Listing
October 2018

Effect of inorganic salt ions on the adsorption of quinoline using coal powder.

Water Sci Technol 2018 Sep;78(3-4):496-505

Chinese National Engineering Research Center of Coal Preparation and Purification, Xuzhou 221116, Jiangsu, China E-mail:

In this study, coal powder was used as the adsorbent for quinoline. The effect of inorganic salt ions on the adsorption was explored, and the results suggest that the addition of inorganic salt ions can enhance both the removal rate and the amount of quinoline adsorbed. The removal rate and adsorbed amount of quinoline were 83.87% and 1.26 mg/g without inorganic salt ions. Under the same adsorption conditions, the removal rate and adsorbed amount of quinoline could reach 90.21% and 1.35 mg/g when Na was present in the solution, and 94.47% and 1.42 mg/g with the presence of Ca. In addition, the adsorption of quinoline using coal fitted the Freundlich isothermal adsorption model. Changes in the Gibbs free energy, entropy and heat of adsorption were all negative, indicating that the adsorption was spontaneous and exothermic. The changes in the absolute value of Gibbs free energy under both Na and Ca were higher than that in the blank(without inorganic salt ions). The pseudo-second-order kinetic model was found to fit the adsorption kinetic data well, and the activation energy of adsorption under Na and Ca were lower than that in the blank. These indicate that the addition of inorganic salt ions was beneficial to the adsorption process.
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http://dx.doi.org/10.2166/wst.2018.300DOI Listing
September 2018