Publications by authors named "Guoqiang Zhong"

29 Publications

  • Page 1 of 1

Characteristics of the Dynamic Electrocardiogram in the Elderly with Nonvalvular Atrial Fibrillation Combined with Long R-R Intervals.

Evid Based Complement Alternat Med 2021 10;2021:4485618. Epub 2021 Nov 10.

ECG Diagnosis Department, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi 530021, China.

Objective: To investigate the characteristics of dynamic electrocardiogram and their clinical implications in elderly patients with nonvalvular atrial fibrillation combined with long R-R intervals.

Methods: Elderly patients diagnosed with nonvalvular atrial fibrillation who were admitted as an inpatient or attended the outpatient department from January 2015 to January 2020 were selected. Patients were divided into two groups based on the presence of a long R-R interval. The characteristics and therapeutic significance of dynamic electrocardiogram between the two groups were compared.

Results: A total of 532 patients were included in our analyses. Of these, 399 patients were in the long R-R interval group and 133 in the nonlong R-R interval group. In 399 patients, there were 48,840 long R-R intervals manifested within 24 hours. The average, slowest, and fastest ventricular rates during sleep time were higher than those in nonsleep time, while the number of long R-R intervals in sleep time was significantly smaller than that in nonsleep time ( < 0.05). Clinical parameters including dizziness/syncope, cerebral infarction, ST-segment changes, platelet count, average hematocrit, prothrombin time (PT), left ventricular systolic function, end-diastolic diameter, pulmonary artery pressure, and left ventricular ejection fraction were comparable between the groups ( > 0.05). When compared with the nonlong R-R interval group, the level of C-reactive protein was slightly lower in the long R-R interval group ( < 0.05). In addition, the long R-R interval group had a higher incidence of atrial premature beats but a lower incidence of ventricular premature beats. Furthermore, the probability of long R-R interval combined with paroxysmal atrial tachycardia, transient ventricular arrest, second-degree atrioventricular block, and complete or incomplete right bundle branch block was higher than that of nonlong R-R interval ( < 0.05). In patients with long R-R interval >3 s, the risk of having second-degree atrioventricular block and complete or incomplete right bundle branch block was significantly lower, while the risk of having transient ventricular arrest was higher when compared to patients with long R-R intervals of 2-3 s ( < 0.05).

Conclusions: Long R-R interval is a common electrocardiographic phenomenon among the elderly with nonvalvular atrial fibrillation. The long R-R interval mostly occurs in nonsleeping time. The average ventricular rate, slowest ventricular rate, and fastest ventricular rate of sleep time are higher than nonsleeping time. Analysis of the characteristics of the dynamic electrocardiogram of these patients may shed light on the mechanisms for long R-R intervals, including the likelihood of concealed conduction and physiological interference in the atrioventricular node, overspeed inhibition, increased vagus nerve tension, or pathological atrioventricular block.
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http://dx.doi.org/10.1155/2021/4485618DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8598370PMC
November 2021

lncRNA KCNQ1OT1 may function as a competitive endogenous RNA in atrial fibrillation by sponging miR‑223‑3p.

Mol Med Rep 2021 12 26;24(6). Epub 2021 Oct 26.

Department of Cardiology, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi 530021, P.R. China.

Atrial fibrillation (AF) is one of the most common forms of cardiac arrhythmia. Novel evidence has indicated that a competing endogenous RNA (ceRNA) mechanism may occur in AF. The present study aimed to identify differentially expressed microRNAs (miRNAs/miRs) in AF and predict their targeting long non‑coding RNAs (lncRNAs) to identify a potential ceRNA network involved in AF using bioinformatics analysis. The GSE68475 microarray dataset was downloaded from the Gene Expression Omnibus database and differentially expressed miRNAs in AF were obtained. In addition, right atrial appendage (RAA) tissues from patients with AF were collected to determine the expression levels of the miRNAs identified following bioinformatics analysis using reverse transcription‑quantitative PCR (n=8 per group). Subsequently, Gene Ontology (GO) functional term and Kyoto Encyclopedia of Genes and Genomes (KEGG) signaling pathway enrichment analyses of the target genes of differentially expressed miRNAs of interest were performed. The potential upstream lncRNAs targeting the identified miRNAs were predicted using bioinformatics analysis. A dual luciferase reporter assay was used to verify the existence of a targeted relationship between the differentially expressed miRNA and lncRNA of interest. The results identified 43 differentially expressed miRNAs, including 23 upregulated miRNAs. The trends in the expression levels of miR‑223‑3p were inconsistent between the microarray data and those recorded in the RAA tissues from patients with persistent AF. Therefore, miR‑223‑3p was selected as the miRNA of interest for further investigations. The target gene of miR‑233‑3p was found to be enriched in 57 GO terms and 21 KEGG signaling pathways. According to the bioinformatics prediction, 69 lncRNAs targeting miR‑223‑3p were identified, including the lncRNA growth arrest‑specific transcript 5, lncRNA KCNQ1 opposite strand/antisense transcript 1 (KCNQ1OT1) and lncRNA MYC‑induced long non‑coding RNA. The results from dual luciferase assay confirmed that miR‑223‑3p was a direct target of KCNQ1OT1. A ceRNA regulatory relationship may exist between KCNQ1OT1 and miR‑223‑3p in AF, providing therefore a novel potential research target for further studies.
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http://dx.doi.org/10.3892/mmr.2021.12510DOI Listing
December 2021

Safety and Efficacy of High Power Shorter Duration Ablation Guided by Ablation Index or Lesion Size Index in Atrial Fibrillation Ablation: A Systematic Review and Meta-Analysis.

J Interv Cardiol 2021 2;2021:5591590. Epub 2021 Jun 2.

Department of Cardiology, The First Affiliated Hospital of Guangxi Medical University, Nanning 530000, Guangxi, China.

Background: High power shorter duration (HPSD) ablation may lead to safe and rapid lesion formation. However, the optimal radio frequency power to achieve the desired ablation index (AI) or lesion size index (LSI) is insubstantial. This analysis aimed to appraise the clinical safety and efficacy of HPSD guided by AI or LSI (HPSD-AI or LSI) in patients with atrial fibrillation (AF).

Methods: The Medline, PubMed, Embase, Web of Science, and the Cochrane Library databases from inception to November 2020 were searched for studies comparing HPSD-AI or LSI and low power longer duration (LPLD) ablation.

Results: Seven trials with 1013 patients were included in the analysis. The analyses verified that HPSD-AI or LSI revealed benefits of first-pass pulmonary vein isolation (PVI) (RR: 1.28; 95% CI: 1.05-1.56, P = 0.01) and acute pulmonary vein reconnection (PVR) (RR: 0.65; 95% CI: 0.48-0.88, P = 0.005) compared with LPLD. HPSD-AI or LSI showed higher freedom from atrial tachyarrhythmia (AT) (RR = 1.32, 95% CI: 1.14-1.53, P = 0.0002) in the subgroup analysis of studies with PVI ± (with or without additional ablation beyond PVI). HPSD-AI or LSI could short procedural time (WMD: -22.81; 95% CI, -35.03 to -10.60, P = 0.0003), ablation time (WMD: -10.80; 95% CI: -13.14 to -8.46, P < .00001), and fluoroscopy time (WMD: -7.71; 95% CI: -13.71 to -1.71, P = 0.01). Major complications and esophageal lesion in HPSD-AI or LSI group were no more than LDLP group (RR: 0.58; 95% CI: 0.20-1.69, P = 0.32) and (RR: 0.84; 95% CI: 0.43-1.61, P = 0.59).

Conclusions: HPSD-AI or LSI was efficient for treating AF with shorting procedural, ablation, and fluoroscopy time, higher first-pass PVI, and reducing acute PVR and may increase freedom from AT for patients with additional ablation beyond PVI compared with LPLD. Moreover, complications and esophageal lesion were low and no different between two groups.
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http://dx.doi.org/10.1155/2021/5591590DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8192211PMC
July 2021

Identification of key immune-related genes and immune infiltration in atrial fibrillation with valvular heart disease based on bioinformatics analysis.

J Thorac Dis 2021 Mar;13(3):1785-1798

Department of Cardiology, First Affiliated Hospital, Guangxi Medical University, Nanning, China.

Background: Atrial fibrillation (AF) is the most common persistent arrhythmia. Valvular heart disease (VHD) and AF frequently coexist. In our study, from performing bioinformatics analysis, we sought to identify immune-related genes (IRGs) and explore the role of immune cell infiltration in AF-VHD in depth, aiming at investigating the potential molecular mechanism and developing new therapeutic targets for AF, including AF-VHD.

Methods: The gene expression of the GSE41177 and GSE79768 datasets were downloaded from the Gene Expression Omnibus database. Differentially expressed genes (DEGs) were analyzed via the limma package in Bioconductor with R software. Differentially expressed immune-related genes (DEIRGs) were selected via combination ImmPort database with DEGs, and the enrichment function and pathway analysis were explored. A protein-protein interaction (PPI) network was built with a Search Tool for the Retrieval of Interacting Genes/Proteins plugin in Cytoscape. The CIBERSORT algorithm was used to evaluate immune infiltration in the left atrial (LA) tissues between AF-VHD and sinus rhythm (SR) patients. Finally, a correlation analysis between key DEIRGs and infiltrating immune cells was performed.

Results: A total of 130 DEIRGs were detected. Enrichment function of DEIRGs demonstrated that they are significant in immune and inflammatory responses. The key DEIRGs assessed by the PPI network and involved in both the immune and inflammatory responses were the C-X-C motif chemokine ligand (CXCL) 1, pro-platelet basic protein (), , and C-C motif chemokine ligand 4 (). The immune infiltration findings indicated that, compared with the LA tissues from SR patients, the tissues from AF-VHD patients contained a higher proportion of gamma delta T cells, but a lower proportion of CD8 and regulatory T cells. The results of correlation analysis demonstrated that was positively correlated with activated mast cells and significantly negatively correlated with resting mast cells. , , and were positively correlated with the infiltration of various immune cells, such as neutrophils, plasma cells, and resting dendritic cells.

Conclusions: The key immune-related genes and the differences in immune infiltration in LA tissues play an essential role in the occurrence and progression of AF-VHD.
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http://dx.doi.org/10.21037/jtd-21-168DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8024788PMC
March 2021

Preliminary assessment of genotoxic effects induced by radiation from EAST usingmicronucleus assay.

J Radiol Prot 2021 Jan 28. Epub 2021 Jan 28.

Chinese Academy of Sciences Institute of Plasma Physics, Hefei, Anhui, CHINA.

During long-pulse deuterium plasma operating in Experimental Advanced Superconducting Tokamak (EAST), a mixed radiation field will be generated, which is mainly composed of fusion neutrons, gamma rays, x-rays and so on. More accurately and effectively dose monitoring methods were developed and established to obtain the ionizing radiation intensity for the stable operation of the device and personnel radiation safety. As we know, there is few reports about the biological effects of radiation induced by fusion neutrons and γ radiation, which is of vital importance to the assessing radiation hazards from fusion devices such as EAST on human being and ecological environment. In present study, three positions in EAST hall were selected to detect genotoxic effects induced by nuclear fusion radiation using Vicia faba micronucleus test for the first time. The doses of neutrons and gamma rays at these places were measured by thermoluminescence dosimeters for four times from June 2019 to May 2020. The radiation doses were decreased as the distances from EAST device shell gradually increased from S1 to S3. Radiation in EAST hall resulted in a significant induction of micronucleus in Vicia faba root tips cells compared to negative control, which was different from micronucleus frequency indued by fission neutrons, γ-rays and other kind of radiation in previous studies. These results indicated that there has existence of potential genotoxic effects induced by radiation from EAST which was different from other radiation and suggested that it was not allowed to enter the experimental hall during the discharge process, and the radiation protection measures should be taken during the necessary maintenance to avoid radiation damage. These newly acquired results will certainly increase our knowledge on the biological effects induced by radiation from nuclear fusion and provide good data support for developing more effective environmental and personnel fusion radiation protection.
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http://dx.doi.org/10.1088/1361-6498/abe0d1DOI Listing
January 2021

Long Noncoding RNA HOTAIR Functions as a Competitive Endogenous RNA to Regulate Connexin43 Remodeling in Atrial Fibrillation by Sponging MicroRNA-613.

Cardiovasc Ther 2020 17;2020:5925342. Epub 2020 Nov 17.

Hypertension Division, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi 530021, China.

Several studies have indicated that long noncoding RNAs (lncRNAs)-HOX transcript antisense RNA (HOTAIR) is involved in some cardiovascular diseases by regulating gene expression as a competitive endogenous RNA (ceRNA). GJA1 encoding Cx43 is one potential target gene of microRNA-613 (miR-613). Meanwhile, there is a potential target regulatory relationship between HOTAIR and miR-613. The present study is aimed at investigating whether HOTAIR functions as a ceRNA to regulate the Cx43 expression in atrial fibrillation (AF) by sponging miR-613. The expressions of HOTAIR, miR-613, and Cx43 were detected in the right atrial appendages of 45 patients with heart valve disease, including 23 patients with chronic AF. The HOTAIR overexpressed and underexpressed HL-1 cell model were constructed to confirm the effect of HOTAIR on Cx43. Then, the Cx43 expression was detected to testify the interplay between HOTAIR and miR-613 after cotransfecting HOTAIR and miR-613. Furthermore, luciferase assays were performed to verify that HOTAIR could regulate Cx43 remolding as a ceRNA by sponging miR-613. The expression of HOTAIR and Cx43 was significantly downregulated in chronic AF group. HOTAIR regulated positively the Cx43 expression in HL-1 cells. The upregulated effect of HOTAIR on the Cx43 expression could be remarkably attenuated by miR-613. Moreover, the inhibitory effect of miR-613 on the Cx43 expression could be obviously mitigated by HOTAIR. At last, luciferase assays confirmed HOTAIR functioned as a ceRNA in the Cx43 expression by sponging miR-613. Our study suggests that HOTAIR, functioning as a ceRNA by sponging miR-613, is an important contributor to Cx43 remolding in AF.
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http://dx.doi.org/10.1155/2020/5925342DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7688347PMC
December 2020

Compressing Deep Networks by Neuron Agglomerative Clustering.

Sensors (Basel) 2020 Oct 23;20(21). Epub 2020 Oct 23.

Department of Electrical and Electronical Engineering, Xi'an Jiaotong-Liverpool University, Suzhou 215123, China.

In recent years, deep learning models have achieved remarkable successes in various applications, such as pattern recognition, computer vision, and signal processing. However, high-performance deep architectures are often accompanied by a large storage space and long computational time, which make it difficult to fully exploit many deep neural networks (DNNs), especially in scenarios in which computing resources are limited. In this paper, to tackle this problem, we introduce a method for compressing the structure and parameters of DNNs based on neuron agglomerative clustering (NAC). Specifically, we utilize the agglomerative clustering algorithm to find similar neurons, while these similar neurons and the connections linked to them are then agglomerated together. Using NAC, the number of parameters and the storage space of DNNs are greatly reduced, without the support of an extra library or hardware. Extensive experiments demonstrate that NAC is very effective for the neuron agglomeration of both the fully connected and convolutional layers, which are common building blocks of DNNs, delivering similar or even higher network accuracy. Specifically, on the benchmark CIFAR-10 and CIFAR-100 datasets, using NAC to compress the parameters of the original VGGNet by 92.96% and 81.10%, respectively, the compact network obtained still outperforms the original networks.
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http://dx.doi.org/10.3390/s20216033DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7660330PMC
October 2020

Impaired Mitophagy: A New Potential Mechanism of Human Chronic Atrial Fibrillation.

Cardiol Res Pract 2020 1;2020:6757350. Epub 2020 Oct 1.

Department of Cardiology, The First Affiliated Hospital of Guangxi Medical University, Guangxi Cardiovascular Institute, Nanning, Guangxi, China.

Mitophagy is an autophagic response and plays essential roles in survival, development, and homeostasis of cells. It has been reported that mitophagic dysfunction is involved in several cardiovascular diseases. However, the effect of mitophagy on atrial fibrillation (AF) is still unknown. Therefore, we investigated the exact role of mitophagy in human chronic AF. Western blot was used to detect the protein abundance. The mitochondrial morphology and structure were observed by transmission electron microscopy. Immunofluorescent stainings were performed to analyze colocalization of mitochondria with autophagosomes or lysosomes. Totally, 43 patients with valvular heart disease undergoing cardiac surgery were selected, including 21 patients with chronic AF. Comparing with the sinus rhythm (SR) group, we found the size and number of mitochondria in atrial myocytes of patients with AF increased significantly. In addition, expression of LC3B II and LC3B II/LC3B I ratio was significantly decreased in the AF group. Moreover, the expression of p62 was markedly elevated in the AF group compared with that in the SR group. The results of immunofluorescence staining and western blot showed an enhanced expression of Cox IV in the AF group. Dual immunofluorescent stainings revealed that mitophagy defect in atrial myocytes of patients with AF resulted from dysfunction in the process of delivery of mitochondria into autophagosomes. For the first time, impaired mitophagy, during the phagocytosis of mitochondria, is associated with human chronic AF. Mitophagy could be a potential therapeutic target for AF.
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http://dx.doi.org/10.1155/2020/6757350DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7547333PMC
October 2020

Key genes associated with non-alcoholic fatty liver disease and acute myocardial infarction.

Med Sci Monit 2020 Jun 28;26:e922492. Epub 2020 Jun 28.

Department of Cardiology Ward 1, The First Affiliated Hospital of Guangxi, Medical University, Guangxi, Nanning, China (mainland).

BACKGROUND With the increasing research on non-alcoholic fatty liver (NAFLD) and acute myocardial infarction (AMI), many evidences show a tight correlation between NAFLD and AMI, however the underlying pathophysiology is still not clear. This study was to identify the potential hub genes and pathways related to these two diseases via bioinformatic method. MATERIAL AND METHODS Gene Expression Omnibus (GEO) dataset GSE63067 of NAFLD patients and normal controls was downloaded from GEO database. The GSE60993 and GSE66360 datasets for AMI patients and healthy controls were also obtained. Differential expression genes (DEGs) of NAFLD and AMI datasets, accompanied with common genes between them were achieved. Further GO and KEGG enrichment analysis for common genes were performed. RESULTS To obtain the pathogenesis associated with both NAFLD and AMI, protein-protein interaction (PPI) network was constructed and the top ten hub genes (TLR2, LILRB2, CXCL1, FPR1, TLR4, TYROBP, MMP9, FCER1G, CLEC4D and CCR2) were selected with CONCLUSIONS The results of this study suggesting some novel genes may play an important role in the occurrence and progression NAFLD and AMI. But more experimental researches and clinical trials need to verify.
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http://dx.doi.org/10.12659/MSM.922492DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7341693PMC
June 2020

Generative adversarial networks with decoder-encoder output noises.

Neural Netw 2020 Jul 9;127:19-28. Epub 2020 Apr 9.

Department of Electrical and Electronical Engineering, Xi'an Jiaotong-Liverpool University, Suzhou 215123, China; Alibaba-Zhejiang University Joint Institute of Frontier Technologies, Hangzhou, China. Electronic address:

In recent years, research on image generation has been developing very fast. The generative adversarial network (GAN) emerges as a promising framework, which uses adversarial training to improve the generative ability of its generator. However, since GAN and most of its variants use randomly sampled noises as the input of their generators, they have to learn a mapping function from a whole random distribution to the image manifold. As the structures of the random distribution and the image manifold are generally different, this results in GAN and its variants difficult to train and converge. In this paper, we propose a novel deep model called generative adversarial networks with decoder-encoder output noises (DE-GANs), which take advantage of both the adversarial training and the variational Bayesian inference to improve GAN and its variants on image generation performances. DE-GANs use a pre-trained decoder-encoder architecture to map the random noise vectors to informative ones and feed them to the generator of the adversarial networks. Since the decoder-encoder architecture is trained with the same data set as the generator, its output vectors, as the inputs of the generator, could carry the intrinsic distribution information of the training images, which greatly improves the learnability of the generator and the quality of the generated images. Extensive experiments demonstrate the effectiveness of the proposed model, DE-GANs.
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http://dx.doi.org/10.1016/j.neunet.2020.04.005DOI Listing
July 2020

Imaging with intracardiac echocardiography compared to transesophageal echocardiography during left atrial appendage occlusion.

Rev Cardiovasc Med 2020 Mar;21(1):93-101

Department of Cardiology, First Affiliated Hospital of Guangxi Medical University, No. 6 Shuangyong Road, Nanning, 530021, Guangxi, P. R. China.

We performed a meta-analysis comparing the procedural and outcomes data and related to left atrial appendage occlusion guided by intracardiac echocardiography (ICE) and transesophageal echocardiography (TEE) in nonvalvular atrial fibrillation patients. Technical success with ICE was significantly similar to that of TEE (odds ratio [OR] 1.38, 95% CI [0.62, 3.09], I = 0%, = 0.43). The peri-procedural complications showed no significant difference between the two groups (OR 0.84, 95% CI [0.57, 1.23], I = 0%, = 0.37). Mortality was similar in procedures using ICE vs TEE (OR 0.89, 95% CI [0.51, 1.57], I = 0%, P = 0.69). Landing zones, procedural time and fluoroscopic times between ICE and TEE showed no significant differences (MD 1.96, 95% CI [-0.01, 3.94], I = 90%, = 0.05; MD -1.64, 95% CI [-13.45, 10.17], I =95%, =0.79; and MD 0.49, 95% CI [-2.18, 3.16], I = 87%, = 0.72, respectively). Imaging with ICE or TEE is associated with similar outcomes in left atrial appendage occlusion procedures.
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http://dx.doi.org/10.31083/j.rcm.2020.01.569DOI Listing
March 2020

Random Shapley Forests: Cooperative Game-Based Random Forests With Consistency.

IEEE Trans Cybern 2020 Mar 23. Epub 2020 Mar 23.

The original random forests (RFs) algorithm has been widely used and has achieved excellent performance for the classification and regression tasks. However, the research on the theory of RFs lags far behind its applications. In this article, to narrow the gap between the applications and the theory of RFs, we propose a new RFs algorithm, called random Shapley forests (RSFs), based on the Shapley value. The Shapley value is one of the well-known solutions in the cooperative game, which can fairly assess the power of each player in a game. In the construction of RSFs, RSFs use the Shapley value to evaluate the importance of each feature at each tree node by computing the dependency among the possible feature coalitions. In particular, inspired by the existing consistency theory, we have proved the consistency of the proposed RFs algorithm. Moreover, to verify the effectiveness of the proposed algorithm, experiments on eight UCI benchmark datasets and four real-world datasets have been conducted. The results show that RSFs perform better than or at least comparable with the existing consistent RFs, the original RFs, and a classic classifier, support vector machines.
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http://dx.doi.org/10.1109/TCYB.2020.2972956DOI Listing
March 2020

Near-Infrared Tunable Laser Absorption Spectroscopic Acetylene Sensor System Using a Novel Three Mirror-Based, Dense Pattern Gas Cell.

Sensors (Basel) 2020 Feb 26;20(5). Epub 2020 Feb 26.

Department of Electrical and Computer Engineering, Rice University, 6100 Main Street, Houston, TX 77005, USA.

By contrast with the widely reported traditional two mirror-based Herriott cell, a three mirror-based dense pattern gas cell was proposed, of which the modeling and design were proven to be effective through a comparison between the simulated spot pattern and effective path length and those of the experimental results. A mechanical structure was designed to adjust the position/angle of the three mirrors for aligning the optical path. The experimentally measured reflection number was 60, resulting in an optical path length of ~11 m, which agrees well with the theoretical value of 10.95 m. Combined with a near-infrared laser with a center wavenumber located at an acetylene (CH) absorption line of 6521.2 cm, a CH sensor system was established to verify the feasibility of the three mirror-based gas cell. Assisted by a data acquisition (DAQ) card, a LabVIEW platform was developed to generate the drive signal of the laser and acquire the second harmonic (2) signal from the output of the detector. Through Allan variance analysis, the limit of detection (LoD) of the sensor system is 4.36 ppm at an average time of 0.5 s; as the average time exceeds 10 s, the LoD is <1 ppm. The proposed model and design of the three mirror-based gas cell can be used to realize similar gas cells with different absorption path lengths for gas detection based on infrared absorption spectroscopy.
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http://dx.doi.org/10.3390/s20051266DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7085622PMC
February 2020

A Network Pharmacology Approach to Estimate the Active Ingredients and Potential Targets of Cuscutae semen in the Treatment of Osteoporosis.

Med Sci Monit 2020 Feb 21;26:e920485. Epub 2020 Feb 21.

Department of Cardiology Ward 1, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China (mainland).

BACKGROUND Osteoporosis is a metabolic osteopathy characterized by abnormal bone mass and microstructure that has become a public health problem worldwide. Cuscutae semen (CS) is a traditional Chinese medicine (TCM) that has a positive effect on the prevention and treatment of osteoporosis. However, the mechanism of CS is unclear. Therefore, this study aimed to reveal the possible molecular mechanism involved in the effects of CS on osteoporosis based on a network pharmacology approach. MATERIAL AND METHODS The inactive and active ingredients of CS were identified by searching the pharmacology analysis platform of the Chinese medicine system (TCMSP), and the targets of osteoporosis were screened in the relevant databases, such as GeneCards, PubMed, and the Comparative Toxicogenomics Database (CTD). The network of "medicine-ingredients-disease-targets (M-I-D-T)" was established by means of network pharmacology, and the key targets and core pathways were determined by R analysis. Molecular docking methods were used to evaluate the binding activity between the target and the active ingredients of CS. RESULTS Eleven active ingredients were identified in CS, and 175 potential targets of the active ingredients were also identified from the TCMSP. Moreover, we revealed 22 539 targets related to osteoporosis in the 3 well-established databases, and we determined the intersection of the disease targets and the potential targets of the active ingredients; 107 common targets were identified and used in further analysis. Additionally, biological processes and signaling pathways involved in target action, such as fluid shear stress, atherosclerosis, cancer pathways, and the TNF signaling pathway, were determined. Finally, we chose the top 5 common targets, CCND1, EGFR, IL6, MAPK8, and VEGFA, for molecular docking with the 11 active ingredients of CS. CONCLUSIONS This study suggested that CS has multiple ingredients and multiple targets relevant to the treatment of osteoporosis. We determined that the active ingredient, sesamin, may be the most crucial ingredient of CS for the treatment of osteoporosis. Additionally, the network pharmacology method provided a novel research approach to analyze the function of complex ingredients.
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http://dx.doi.org/10.12659/MSM.920485DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7047917PMC
February 2020

Development of neutron activation system on EAST.

Rev Sci Instrum 2020 Jan;91(1):013503

Institute of Plasma Physics, Chinese Academy of Sciences, Hefei 230031, China.

A neutron activation system (NAS) has been developed on the Experimental Advanced Superconducting Tokamak (EAST) for the investigation of time-integrated neutron yield. It is a robust neutron diagnostic with high precision and a wide dynamic range. Some high purity materials with a proper nuclear reaction energy threshold and cross section are tested as neutron detectors in the NAS, and they are delivered to the tokamak device by a pneumatic transfer system. The length of the pneumatic pipeline is about 50 m, and the transfer time ranges from 10 s to 20 s. The decay gamma rays of the activated samples are measured with a high-purity germanium spectrometer, and its detection efficiencies are 6.9% at 336 keV and 1.7% at 1779 keV, respectively. Indium and silicon samples with a reaction threshold of 0.3 MeV and 4.0 MeV, respectively, were successfully implemented in the diagnosis of DD and DT neutron yield in the EAST. The neutron flux of the NAS was compared with the count of the fission chamber in the EAST neutral beam injection experiment, and the DD neutron yield evaluated by the NAS ranges from 1.9 × 10 n/shot to 5.9 × 10 n/shot during recent experimental campaign.
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http://dx.doi.org/10.1063/1.5126746DOI Listing
January 2020

Generative adversarial networks with mixture of t-distributions noise for diverse image generation.

Neural Netw 2020 Feb 18;122:374-381. Epub 2019 Nov 18.

Department of Electrical and Electronical Engineering, Xi'an Jiaotong-Liverpool University, Suzhou 215123, China; Alibaba-Zhejiang University Joint Institute of Frontier Technologies, Hangzhou, 310058, China. Electronic address:

Image generation is a long-standing problem in the machine learning and computer vision areas. In order to generate images with high diversity, we propose a novel model called generative adversarial networks with mixture of t-distributions noise (tGANs). In tGANs, the latent generative space is formulated using a mixture of t-distributions. Particularly, the parameters of the components in the mixture of t-distributions can be learned along with others in the model. To improve the diversity of the generated images in each class, each noise vector and a class codeword are concatenated as the input of the generator of tGANs. In addition, a classification loss is added to both the generator and the discriminator losses to strengthen their performances. We have conducted extensive experiments to compare tGANs with a state-of-the-art pixel by pixel image generation approach, pixelCNN, and related GAN-based models. The experimental results and statistical comparisons demonstrate that tGANs perform significantly better than pixleCNN and related GAN-based models for diverse image generation.
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http://dx.doi.org/10.1016/j.neunet.2019.11.003DOI Listing
February 2020

Cobalt-Catalyzed Direct Carbonylative Synthesis of Free ()-Benzo[]indol-2(1)-ones from Naphthylamides.

Org Lett 2019 07 27;21(14):5694-5698. Epub 2019 Jun 27.

Department of Chemistry , Zhejiang Sci-Tech University , Xiasha Campus, Hangzhou 310018 , People's Republic of China.

A cobalt-catalyzed C-H carbonylation of naphthylamides for the synthesis of benzo[]indol-2(1)-one scaffolds has been developed. The reaction employs a traceless directing group and uses benzene-1,3,5-triyl triormate as the CO source, affording various free ()-benzo[]indol-2(1)-ones in moderate to high yields (up to 88%). Using this protocol, the total synthesis of BET bromodomain inhibitors A and B was accomplished as well.
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http://dx.doi.org/10.1021/acs.orglett.9b02037DOI Listing
July 2019

Overexpression of miR-27b-3p Targeting Wnt3a Regulates the Signaling Pathway of Wnt/-Catenin and Attenuates Atrial Fibrosis in Rats with Atrial Fibrillation.

Oxid Med Cell Longev 2019 17;2019:5703764. Epub 2019 Apr 17.

Departments of Cardiology, First Affiliated Hospital of Guangxi Medical University, Nanning 530021, Guangxi Zhuang Autonomous Region, China.

MicroRNAs (miRNAs) are regarded as a potential method for the treatment of atrial fibrillation (AF) although its molecular mechanism remains unknown. We found in our previous study that the level of peripheral blood miR-27b-3p and the expression of atrial tissue CX43 were both significantly downregulated in AF patients. In the present study, we propose and test this hypothesis that overexpression of miR-27b-3p attenuates atrial fibrosis, increases CX43 expression, and regulates the signaling pathway of Wnt/-Catenin by targeting Wnt3a. miR-27b-3p overexpression was induced by rat tail vein injection of adeno-associated virus. Two weeks after transfection of adeno-associated virus, the rat AF model was established by tail vein injection of acetylcholine- (ACh-) CaCl for 7 days, and 1 ml/kg was injected daily. The incidence and duration of AF were recorded with an electrocardiogram. Cardiac function was monitored by cardiac ultrasound. Serum cardiac enzyme was detected by ELISA. The expression of atrial miR-27b-3 and Wnt3a was assayed by quantitative RT-PCR. Atrial fibrosis was determined by Masson's trichrome staining. Expression of atrial Collagen-I and Collagen-III was tested by the immunohistochemical method. Expression of CX43 was measured by immunofluorescence. The expression of Collagen-I, a-SMA, Collagen-III, TGF-1, CX43, Wnt3a, -Catenin, and p--Catenin was assayed by western blot. Our results showed that miR-27b-3p overexpression could reduce the incidence and duration of AF, alleviate atrial fibrosis, increase atrial CX43 expression, and decrease the expression of Collagen-I, a-SMA, Collagen-III, TGF-1, Wnt3a, and p--Catenin. In addition, the results of luciferase activity assay showed that Wnt3a is a validated miR-27b-3p target in HEK 293T cells. Our results provide a new evidence that miR-27b-3p regulates the signaling pathway of Wnt/-Catenin by targeting Wnt3a, which may play an important role in the development of atrial fibrosis and AF.
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http://dx.doi.org/10.1155/2019/5703764DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6501122PMC
January 2020

Banzhaf random forests: Cooperative game theory based random forests with consistency.

Neural Netw 2018 Oct 28;106:20-29. Epub 2018 Jun 28.

Department of Computer Science and Technology, Ocean University of China, 238 Songling Road, Qingdao 266100, China.

Random forests algorithms have been widely used in many classification and regression applications. However, the theory of random forests lags far behind their applications. In this paper, we propose a novel random forests classification algorithm based on cooperative game theory. The Banzhaf power index is employed to evaluate the power of each feature by traversing possible feature coalitions. Hence, we call the proposed algorithm Banzhaf random forests (BRFs). Unlike the previously used information gain ratio, which only measures the power of each feature for classification and pays less attention to the intrinsic structure of the feature variables, the Banzhaf power index can measure the importance of each feature by computing the dependency among the group of features. More importantly, we have proved the consistency of BRFs, which narrows the gap between the theory and applications of random forests. Extensive experiments on several UCI benchmark data sets and three real world applications show that BRFs perform significantly better than existing consistent random forests on classification accuracy, and better than or at least comparable with Breiman's random forests, support vector machines (SVMs) and k-nearest neighbors (KNNs) classifiers.
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http://dx.doi.org/10.1016/j.neunet.2018.06.006DOI Listing
October 2018

6-Gingerol Activates PI3K/Akt and Inhibits Apoptosis to Attenuate Myocardial Ischemia/Reperfusion Injury.

Evid Based Complement Alternat Med 2018 20;2018:9024034. Epub 2018 Mar 20.

Department of Cardiology, First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi Zhuang Autonomous Region 530021, China.

6-Gingerol (6-G) is known to alleviate myocardial ischemia/reperfusion injury. However, the underlying molecular mechanisms of 6-G myocardial protection are not known. In this study, the protective effect of 6-G on ischemia/reperfusion (I/R) damage and whether such a mechanism was related to apoptosis inhibition and activation of phosphoinositide 3-kinases (PI3K)/serine/threonine kinase (Akt) signaling pathway were investigated. Rats were subjected to I/R in the presence or absence of 6-G and the changes of cardiac function, infarct size and histopathological changes, and the levels of cardiac troponin T, creatine kinase-MB, and myocardial apoptosis were examined. The expression of caspase-3, PI3K, p-Akt, and Akt was also determined. We found that 6-G (6 mg/kg) pretreatment significantly improved heart function and ameliorated infarct size and histopathological changes and cardiac troponin T and creatine kinase-MB levels induced by I/R. Moreover, pretreatment with 6-G significantly inhibited myocardial apoptosis and caspase-3 activation induced by I/R. 6-G also upregulated expression of PI3K, p-Akt, and Akt in myocardial tissues. Taken together, these findings suggest that 6-G inhibits apoptosis and activates PI3K/Akt signaling in response to myocardial I/R injury as a possible mechanism to attenuate I/R-induced injury in heart. These results might be important for developing novel strategies for preventing myocardial I/R injury.
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http://dx.doi.org/10.1155/2018/9024034DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5884032PMC
March 2018

Double-range near-infrared acetylene detection using a dual spot-ring Herriott cell (DSR-HC).

Opt Express 2018 Apr;26(9):12081-12091

Design and fabrication of a dual spot-ring Herriott cell (DSR-HC) were proposed. The sealed Herriott cell with a dimensional size of 5.5 cm × 9.2 cm × 32.1 cm, possessed two input/output coupling holes leading to two absorption path lengths of ~20 m and ~6 m, respectively. An acetylene (CH) sensor system with a double-range was developed using the DSR-HC and wavelength modulation spectroscopy (WMS) technique. A near-infrared distributed feedback (DFB) laser was employed for targeting a CH absorption line at 6521.2 cm. CH concentration measurements were carried out by modulating the laser at a 5 kHz frequency and demodulating the detector signal with LabVIEW software. An Allan-Werle deviation analysis indicated that the limit of detection (LoD) for the two absorption path lengths of 20 m and 6 m are 7.9 parts-per-million in volume (ppmv) and 4.0 ppmv, respectively. The DSR-HC concept can be used to fabricate similar cells for single-gas detection requiring two different detection ranges as well as for dual-gas detection requiring different absorption path lengths.
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April 2018

MicroRNA-208a-3p contributes to connexin40 remolding in human chronic atrial fibrillation.

Exp Ther Med 2017 Dec 29;14(6):5355-5362. Epub 2017 Sep 29.

Department of Cardiology, The First Affiliated Hospital, Guangxi Medical University, Nanning, Guangxi 530021, P.R. China.

Previous studies have demonstrated that connexin40 (Cx40) remolding is involved in atrial fibrillation (AF). GJA5 encoding Cx40 is a potential target mRNA of microRNA-208a-3p (miR-208a-3p), as indicated by preliminary bioinformatics analyses. However, the exact effect of miR-208a-3p on Cx40 in human chronic AF has remained elusive. The present study demonstrated the role of miR-208a-3p in human chronic AF and further investigated the effect of miR-208a-3p on Cx40 expression. A total of 19 patients with AF and 18 patients with sinus rhythm (SR) were enrolled. The AC16 cell line was treated with miR-208a-3p inhibitor or mimics. The miR-208a-3p in right atrial appendage (RAA) tissues of patients was measured by hybridization and reverse-transcription quantitative polymerase chain reaction (RT-qPCR). Furthermore, the expression of Cx40 in the RAA of patients and in AC16 cells treated with miR-208a-3p inhibitor or mimics were detected by RT-qPCR and western blot analysis. A luciferase assay was performed to confirm whether Cx40 was directly targeted by miR-208a-3p. The miR-208a-3p levels in patients with AF were significantly increased compared with those in patients with SR. Conversely, the Cx40 protein levels were significantly decreased and lateralization of Cx40 was observed in patients with AF. miR-208a-3p inhibitor led to a significant upregulation of the protein expression of Cx40 in AC16 cells, while miR-208a-3p mimics led to a significant downregulation. However, the luciferase assay demonstrated that GJA5 was not a direct target gene of miR-208a-3p. The findings still suggested that miR-208a-3p may be involved in human chronic AF by mediating atrial Cx40 remolding, and may represent a potential therapeutic target for AF.
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http://dx.doi.org/10.3892/etm.2017.5225DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5740716PMC
December 2017

Mono-Heteromeric Configurations of Gap Junction Channels Formed by Connexin43 and Connexin45 Reduce Unitary Conductance and Determine both Voltage Gating and Metabolic Flux Asymmetry.

Front Physiol 2017 29;8:346. Epub 2017 May 29.

Cardiovascular Research and Training Institute (CVRTI), Department of Bioengineering, University of UtahSalt Lake Citiy, UT, United States.

In cardiac tissues, the expression of multiple connexins (Cx40, Cx43, Cx45, and Cx30.2) is a requirement for proper development and function. Gap junctions formed by these connexins have distinct permeability and gating mechanisms. Since a single cell can express more than one connexin isoform, the formation of hetero-multimeric gap junction channels provides a tissue with an enormous repertoire of combinations to modulate intercellular communication. To study further the perm-selectivity and gating properties of channels containing Cx43 and Cx45, we studied two monoheteromeric combinations in which a HeLa cell co-transfected with Cx43 and Cx45 was paired with a cell expressing only one of these connexins. Macroscopic measurements of total conductance between cell pairs indicated a drastic reduction in total conductance for mono-heteromeric channels. In terms of Vj dependent gating, Cx43 homomeric connexons facing heteromeric connexons only responded weakly to voltage negativity. Cx45 homomeric connexons exhibited no change in Vj gating when facing heteromeric connexons. The distributions of unitary conductances (γj) for both mono-heteromeric channels were smaller than predicted, and both showed low permeability to the fluorescent dyes Lucifer yellow and Rhodamine123. For both mono-heteromeric channels, we observed flux asymmetry regardless of dye charge: flux was higher in the direction of the heteromeric connexon for MhetCx45 and in the direction of the homomeric Cx43 connexon for MhetCx43. Thus, our data suggest that co-expression of Cx45 and Cx43 induces the formation of heteromeric connexons with greatly reduced permeability and unitary conductance. Furthermore, it increases the asymmetry for voltage gating for opposing connexons, and it favors asymmetric flux of molecules across the junction that depends primarily on the size (not the charge) of the crossing molecules.
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http://dx.doi.org/10.3389/fphys.2017.00346DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5447054PMC
May 2017

Efficacy and safety of the second-generation cryoballoons versus radiofrequency ablation for the treatment of paroxysmal atrial fibrillation: a systematic review and meta-analysis.

J Interv Card Electrophysiol 2017 Jan 28;48(1):69-79. Epub 2016 Sep 28.

Guangxi Key Laboratory of AIDS Prevention and Treatment, School of Public Health, Guangxi Medical University, Nanning, People's Republic of China.

Purpose: Currently, radiofrequency (RF) and cryoballoon are the most commonly used ablation technologies for atrial fibrillation (AF). We performed a meta-analysis to assess the efficacy and safety of the second-generation cryoballoons (CB-2) compared with RF for paroxysmal atrial fibrillation (PAF) ablation.

Methods: The PubMed, Cochrane Library, and Embase databases were searched and qualified studies were identified. The primary clinical outcome was the recurrence rate of atrial tachyarrhythmia (AT), and the secondary clinical outcomes were procedure time, fluoroscopy time, and the complications that followed.

Results: Nine observational studies (2336 patients) with a mean follow-up period ranging from 8.8 to 16.8 months were included. The CB-2 group was associated with a significantly lower recurrence rate of ATs (20.8 versus 29.8 %, p = 0.01). In subgroup analysis, compared with non-contact force sensing (NCF) catheter, using CB-2 showed significantly reduced incidence of ATs (22.0 versus 38.5 %, p < 0.00001). However, the difference became negligible in contrast with contact force sensing (CF) catheter. Moreover, the CB-2 group had a tendency to decrease procedure time (weighted mean difference -39.72 min, p = 0.0003), whereas fluoroscopy time was similar between the two groups. The total complication rate showed no statistical difference (8.8 versus 4.4 %, p = 0.08). Almost all the cases of phrenic nerve palsy occurred in the CB-2 group, whereas pericardial tamponade was seldom manifested in the CB-2 group.

Conclusions: CB-2 tended to be more effective in comparison to NCF catheter and at least non-inferior to CF catheter, with shorter procedure time and similar safety endpoint.
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http://dx.doi.org/10.1007/s10840-016-0191-9DOI Listing
January 2017

The Role of Platelet-Derived Growth Factor-B/Platelet-Derived Growth Factor Receptor-β Signaling in Chronic Atrial Fibrillation.

Cardiology 2016 12;133(4):242-56. Epub 2016 Jan 12.

Department of Cardiology, First Affiliated Hospital, Guangxi Medical University, Nanning, China.

Objective: To explore the role of platelet-derived growth factor-B (PDGF-B)/platelet-derived growth factor receptor-β (PDGFR-β) signaling in chronic atrial fibrillation (AF).

Methods: Thirty-nine AF patients and 33 patients with sinus rhythm (SR) were enrolled. Twenty canines were randomized into 5 groups: control, sham and AF lasting 1, 2 or 4 weeks. The AF canine models were made by rapid atrial pacing. Rat atrial fibroblasts were treated with PDGF-BB or PDGF-BB + PDGFR inhibitor AG1295, respectively. Gene expression in the right atrial appendage of patients, the left atrium of canines and rat atrial fibroblasts was measured by quantitative real-time PCR and Western blot, respectively. The degree of atrial fibrosis was evaluated by Masson trichrome staining.

Results: The degree of atrial fibrosis and the expression of PDGF-B, PDGFR-β and collagen type I (COL1) in AF patients significantly increased compared to patients with SR. The degree of atrial fibrosis and the expression of PDGF-B and COL1 in canines increased progressively with the increased duration of AF. The expression of PDGFR-β increased progressively 2 weeks after AF. PDGF-BB promoted the proliferation and COL1 secretion of rat atrial fibroblasts. AG1295 attenuated these effects.

Conclusions: Our study suggests that PDGF-B/PDGFR-β signaling, which promotes the proliferation and COL1 secretion of atrial fibroblasts, is an important contributor to atrial fibrosis in AF and may represent a novel target for the intervention of AF.
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http://dx.doi.org/10.1159/000442940DOI Listing
October 2016

Large margin low rank tensor analysis.

Neural Comput 2014 Apr 30;26(4):761-80. Epub 2014 Jan 30.

Synchromedia Laboratory for Multimedia Communication in Telepresence, École de Technologie Supérieure, Montréal, Québec H3C 1K3, Canada

We present a supervised model for tensor dimensionality reduction, which is called large margin low rank tensor analysis (LMLRTA). In contrast to traditional vector representation-based dimensionality reduction methods, LMLRTA can take any order of tensors as input. And unlike previous tensor dimensionality reduction methods, which can learn only the low-dimensional embeddings with a priori specified dimensionality, LMLRTA can automatically and jointly learn the dimensionality and the low-dimensional representations from data. Moreover, LMLRTA delivers low rank projection matrices, while it encourages data of the same class to be close and of different classes to be separated by a large margin of distance in the low-dimensional tensor space. LMLRTA can be optimized using an iterative fixed-point continuation algorithm, which is guaranteed to converge to a local optimal solution of the optimization problem. We evaluate LMLRTA on an object recognition application, where the data are represented as 2D tensors, and a face recognition application, where the data are represented as 3D tensors. Experimental results show the superiority of LMLRTA over state-of-the-art approaches.
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http://dx.doi.org/10.1162/NECO_a_00570DOI Listing
April 2014

A compact stilbene crystal neutron spectrometer for EAST D-D plasma neutron diagnostics.

Rev Sci Instrum 2013 Mar;84(3):033506

School of Physics and State Key Laboratory of Nuclear Physics and Technology, Peking University, Chengfu Road 201, 100871 Beijing, China.

A new compact stilbene crystal neutron spectrometer has been investigated and applied in the neutron emission spectroscopy on the EAST tokamak. A new components analysis method is presented to study the anisotropic light output in the stilbene crystal detector. A Geant4 code was developed to simulate the neutron responses in the spectrometer. Based on both the optimal light output function and the fitted pulse height resolution function, a reliable neutron response matrix was obtained by Geant4 simulations and validated by 2.5 MeV and 14 MeV neutron measurements at a 4.5 MV Van de Graaff accelerator. The spectrometer was used to diagnose the ion temperature in plasma discharges with lower hybrid wave injection and ion cyclotron resonance heating on the EAST tokamak.
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http://dx.doi.org/10.1063/1.4797623DOI Listing
March 2013

Meta-analysis of effect of vernakalant on conversion of atrial fibrillation.

BMC Res Notes 2013 Mar 13;6:94. Epub 2013 Mar 13.

Department of Cardiology, The First Affiliated Hospital of Guangxi Medical University, Guangxi province, China.

Background: In recent years, there has been a large amount of studies about the efficacy and safety of vernakalant or RSD1235, an antiarrhythmic agent, in treating the atrial fibrillation (AF). This study was designed to assess the efficacy and safety of vernakalant in the treatment of AF.

Results: A total of 5 randomized controlled trials (RCTs) (n= 1153) met our inclusion criteria. Vernakalant was superior in achieving sinus rhythm (SR) for AF comparing to placebo or alternative anti-arrhythmic agents (relative risk [RR] = 11.56, 95% Confidence Interval [CI] = 7.12 - 18.75). There was no heterogeneity among the trials (X(2) =0.59, P = 0.96). In analysing the adverse effects of cardiac origin, there was no significant difference between the two groups (RR= 0.90, 95% CI = 0.52 - 1.57).

Methods: The Cochrane library, Pubmed NCBI, EMBASE and MEDLINE were systematically searched to identify all interventional trials of vernakalant with placebo or other antiarrhythmic drug in converting AF to SR. The primary outcome was rate of converting to SR, and the secondary outcome was the rate of adverse effects of cardiac origin due to vernakalant and the placebo or amiodarone. Meta-analyses were carried out using Mantel-Haenszel fixed-effects or random-effects models and heterogeneity was by the X(2) test.

Conclusion: In the conversion of AF to SR, vernakalant is highly effective without obviously raised side effects. Owing to only one study comparing vernakalant with amiodarone included in this study, the efficacy of vernakalant comparing to other antiarrhythmic agents needing more well-designed double-blinded RCTs to be confirmed.
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http://dx.doi.org/10.1186/1756-0500-6-94DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3610119PMC
March 2013

Cardiac resynchronization therapy in patients with mild heart failure: a systematic review and meta-analysis of randomized controlled trials.

Cardiovasc Drugs Ther 2011 Aug;25(4):331-40

Department of Geriatric Cardiology, First Afiliated Hospital, Guangxi Medical University, 22 Shuangyong Road, 530000, Nanning, Guangxi, People's Republic of China.

Objective: This review aims at updating the results of cardiac resynchronization therapy (CRT) in mild heart failure patients, and investigating whether CRT can prevent or reverse heart failure progression in an earlier stage.

Methods: Randomized controlled trials of CRT in patients with New York Heart Association (NYHA) Class I or II heart failure were identified. The effects of CRT on worsening heart failure hospitalization, all-cause mortality, and overall adverse events were meta-analyzed, and the effects of CRT on left ventricular (LV) were systematically reviewed and meta-analyzed.

Results: Eight studies were identified with a total of 4,302 patients. CRT was associated with a substantial improvement in LV end-systolic volume (WMD -39, 95%CI -41.56 to -36.45). CRT also had a marked effect in reducing new hospitalizations for worsening heart failure by 31% (RR 0.69, 95%CI 0.60 to 0.79). In addition, CRT significantly decreased all-cause mortality by 21% (RR 0.79, 95%CI 0.67 to 0.93). However, complications in patients with CRT increased by 74% (RR 1.74, 95%CI 1.44 to 2.11).

Conclusions: This meta-analysis suggests that CRT could improve the prognosis in patients with mild heart failure and ventricular dyssynchrony, but these improvements are accompanied by more adverse events. Since most patients in the included trials had received ICD therapy, our analysis suggests that CRT could offer an additional benefit.
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http://dx.doi.org/10.1007/s10557-011-6313-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3151402PMC
August 2011
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