Publications by authors named "Guoqiang Ma"

17 Publications

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Simultaneous implant placement with autogenous onlay bone grafts: a systematic review and meta-analysis.

Int J Implant Dent 2021 Apr 30;7(1):61. Epub 2021 Apr 30.

Department of Oral Implantology, Jinhua Stomatological Hospital, 277 Silian Rd, Jinhua, 321000, Zhejiang Province, People's Republic of China.

Several authors have suggested that implants can be placed simultaneously with onlay bone grafts without affecting outcomes. Therefore, the purpose of this study was to answer the following clinical questions: (1) What are the outcomes of implants placed simultaneously with autogenous onlay bone grafts? And (2) is there a difference in outcomes between simultaneous vs delayed placement of implants with autogenous onlay bone grafts? Databases of PubMed, Embase, and Google Scholar were searched up to 15 November 2020. Data on implant survival was extracted from all the included studies (single arm and comparative) to calculate point estimates with 95% confidence intervals (CI) and pooled using the DerSimonian-Laird meta-analysis model. We also compared implant survival rates between the simultaneous and delayed placement of implants with data from comparative studies. Nineteen studies were included. Five of them compared simultaneous and delayed placement of implants. Dividing the studies based on follow-up duration, the pooled survival of implant placed simultaneously with onlay grafts after <2.5 years of follow-up was 93.1% (95% CI 82.6 to 97.4%) and after 2.5-5 years was 86% (95% CI 78.6 to 91.1%). Implant survival was found to be 85.8% (95% CI 79.6 to 90.3%) with iliac crest grafts and 95.7% (95% CI 83.9 to 93.0%) with intra-oral grafts. Our results indicated no statistically significant difference in implant survival between simultaneous and delayed placement (OR 0.43, 95% 0.07, 2.49, I=59.04%). Data on implant success and bone loss were limited. Data indicates that implants placed simultaneously with autogenous onlay grafts have a survival rate of 93.1% and 86% after a follow-up of <2.5 years and 2.5-5years respectively. A limited number of studies indicate no significant difference in implant survival between the simultaneous and delayed placement of implants with onlay bone grafts. There is a need for randomized controlled trials comparing simultaneous and delayed implant placement to provide robust evidence.
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http://dx.doi.org/10.1186/s40729-021-00311-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8085156PMC
April 2021

Comparative transcriptomic and metabolomic analyses of carotenoid biosynthesis reveal the basis of white petal color in Brassica napus.

Planta 2021 Jan 2;253(1). Epub 2021 Jan 2.

Chongqing Rapeseed Engineering Research Center, College of Agronomy and Biotechnology, Southwest University, Chongqing, 400715, China.

Main Conclusion: The molecular mechanism underlying white petal color in Brassica napus was revealed by transcriptomic and metabolomic analyses. Rapeseed (Brassica napus L.) is one of the most important oilseed crops worldwide, but the mechanisms underlying flower color in this crop are known less. Here, we performed metabolomic and transcriptomic analyses of the yellow-flowered rapeseed cultivar 'Zhongshuang 11' (ZS11) and the white-flowered inbred line 'White Petal' (WP). The total carotenoid contents were 1.778-fold and 1.969-fold higher in ZS11 vs. WP petals at stages S2 and S4, respectively. Our findings suggest that white petal color in WP flowers is primarily due to decreased lutein and zeaxanthin contents. Transcriptome analysis revealed 10,116 differentially expressed genes with a fourfold or greater change in expression (P-value less than 0.001) in WP vs. ZS11 petals, including 1,209 genes that were differentially expressed at four different stages and 20 genes in the carotenoid metabolism pathway. BnNCED4b, encoding a protein involved in carotenoid degradation, was expressed at abnormally high levels in WP petals, suggesting it might play a key role in white petal formation. The results of qRT-PCR were consistent with the transcriptome data. The results of this study provide important insights into the molecular mechanisms of the carotenoid metabolic pathway in rapeseed petals, and the candidate genes identified in this study provide a resource for the creation of new B. napus germplasms with different petal colors.
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http://dx.doi.org/10.1007/s00425-020-03536-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7778631PMC
January 2021

High-Conductivity, Flexible and Transparent PEDOT:PSS Electrodes for High Performance Semi-Transparent Supercapacitors.

Polymers (Basel) 2020 Feb 14;12(2). Epub 2020 Feb 14.

China-Australia Institute for Advanced Materials and Manufacturing (IAMM), Jiaxing University, Jiaxing 314001, China.

Herein, we report a flexible high-conductivity transparent electrode (denoted as S-PH1000), based on conducting polymer poly(3,4-ethylenedioxythiophene):poly(styrene sulfonate) (PEDOT:PSS), and itsapplication to flexible semi-transparentsupercapacitors. A high conductivity of 2673 S/cm was achieved for the S-PH1000 electrode on flexible plastic substrates via a HSO treatment with an optimized concentration of 80 wt.%. This is among the top electrical conductivities of PEDOT:PSS films processed on flexible substrates. As for the electrochemical properties,a high specific capacitance of 161F/g was obtained from the S-PH1000 electrode at a current density of 1 A/g. Excitingly, a specific capacitance of 121 F/g was retained even when the current density increased to 100 A/g, which demonstrates the high-rate property of this electrode. Flexible semi-transparent supercapacitors based on these electrodes demonstrate high transparency, over 60%, at 550 nm. A high power density value, over 19,200 W/kg,and energy density, over 3.40 Wh/kg, was achieved. The semi-transparent flexible supercapacitor was successfully applied topower a light-emitting diode.
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http://dx.doi.org/10.3390/polym12020450DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7077632PMC
February 2020

Pedaling Performance Changing of Elite Cyclists Is Mainly Determined by the Fatigue of Hamstring and Vastus Muscles during Repeated Sprint Cycling Exercise.

Biomed Res Int 2020 3;2020:7294820. Epub 2020 Jan 3.

Physical Education and Sports Science Institute of Shanghai, Shanghai 200030, China.

Repeated sprint cycling is an effective training method in promoting athletic performance of cyclists, which may induce severe fatigue of lower limb muscles. However, the relationship between the fatigue of each lower limb muscles and the changing of exercise performance remains unclear. In this study, ten cyclist volunteers performed a series of 6-second sprints with 24-s recovery for five times. Power, cadence, and EMG mean frequency (MNF) of each lower limb muscle group for every 2-second epoch, as well as the grey relational grade between exercise performance and MNF of each lower limb muscle group during the whole process were calculated. It has been found that MNF of Rectus femoris (RF), Vastus (VAS), Gastrocnemius (GAS), and the hamstring muscle group (HAM) showed significant negative correlation with the increase in both sprint number and intrasprint duration time, while the grey relational grade of HAM and VAS was higher than that of other muscles. The results demonstrated that the exercise performance of both power and cadence were most closing related to the fatigue degree of HAM and VAS during repeated sprint cycling exercise.
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http://dx.doi.org/10.1155/2020/7294820DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6970493PMC
September 2020

An evaluating system for wetland ecological health: Case study on nineteen major wetlands in Beijing-Tianjin-Hebei region, China.

Sci Total Environ 2019 May 21;666:1080-1088. Epub 2019 Feb 21.

Wetland Management Bureau of State Forestry & Grassland Administration, Beijing 100714, China.

Wetland is one of the three major ecosystems on the earth and has fundamental ecological functions and plays an irreplaceable role in serving biological survival and human development. Considering the characteristics of five types of wetlands, this study constructed a wetland ecological health evaluation indicator system using a wide variety of data from statistical report, field sampling, remote sensing, and questionnaire survey. In this study, we have selected 13 indicators (related to water, soil, biological, landscape and social factors) for ecological health evaluation of 19 wetlands in Beijing-Tianjin-Hebei region of China which have national importance. The detailed analysis shows a comprehensive health index of 5.53. There was significant spatial heterogeneity in the health status of the 19 wetlands in this region. The evaluation results and analysis provides scientific services for developing reasonable and targeted wetland protection and utilization policies of wetlands.
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http://dx.doi.org/10.1016/j.scitotenv.2019.02.325DOI Listing
May 2019

Effect of Recrystallization Annealing on Corrosion Behavior of Ta-4%W Alloy.

Materials (Basel) 2018 Dec 31;12(1). Epub 2018 Dec 31.

Southwest Technology and Engineering Research Institute, Chongqing 400039, China.

The effect of recrystallization annealing on corrosion behavior of Ta-4%W alloy was studied. It is found that the deformed sample contains high dense dislocations and dislocation boundaries. During annealing, these dislocations and dislocation boundaries are replaced by recrystallizing grains until the alloy is fully recrystallized. Both the anodic dissolution and the cathodic activity is much more blocked. The corrosion potential gradual shift towards negative values and corrosion current density decrease, while polarization resistance increases after annealing, indicating enhanced corrosion resistance of the alloy. Such an enhancement is caused by the increase of low-Σ coincide site lattice boundaries and decrease of dislocations and dislocation boundaries.
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http://dx.doi.org/10.3390/ma12010117DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337339PMC
December 2018

Genome-Wide Characterization and Analysis of Metallothionein Family Genes That Function in Metal Stress Tolerance in L.

Int J Mol Sci 2018 Jul 26;19(8). Epub 2018 Jul 26.

Academy of Agricultural Sciences, Southwest University, Chongqing 400715, China.

plants exhibit both high biomass productivity and high rates of heavy metal absorption. Metallothionein (MT) proteins are low molecular weight, cysteine-rich, metal-binding proteins that play crucial roles in protecting plants from heavy metal toxicity. However, to date, MT proteins have not been systematically characterized in . In this study, we identified 60 MTs from and five species. All the MT family genes from Brassica are closely related to MTs, encoding putative proteins that share similar functions within the same clades. Genome mapping analysis revealed high levels of synteny throughout the genome due to whole genome duplication and segmental duplication events. We analyzed the expression levels of 16 MTs () by RNA-sequencing and real-time RT-PCR (RT-qPCR) analysis in plants under As stress. These genes exhibited different expression patterns in various tissues. Our results suggest that plays a key role in the response to As stress in . This study provides insight into the phylogeny, origin, and evolution of MT family members in , laying the foundation for further studies of the roles of MT proteins in these important crops.
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http://dx.doi.org/10.3390/ijms19082181DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6121329PMC
July 2018

A Comparative Study of EMG Indices in Muscle Fatigue Evaluation Based on Grey Relational Analysis during All-Out Cycling Exercise.

Biomed Res Int 2018 16;2018:9341215. Epub 2018 Apr 16.

Sport and Health Research Center, Physical Education Department, Tongji University, Shanghai, China.

The increased popularization of cycling has brought an increase in cycling-related injuries, which has been suggested to be associated with muscle fatigue. However, it still remains unclear on the utility of different EMG indices in muscle fatigue evaluation induced by cycling exercise. In this study, ten cyclist volunteers performed a 30-second all-out cycling exercise after a warm-up period. Surface electromyography (sEMG) from vastus lateralis muscle (VL) and power output and cadence were recorded and EMG RMS, MF and MPF based on Fourier Transform, MDF and MNF based on wavelet packet transformation, and C(n) based on Lempel-Ziv complexity algorithm were calculated. Utility of the indices was compared based on the grey rational grade of sEMG indices and power output and cadence. The results suggested that MNF derived from wavelet packet transformation was significantly higher than other EMG indices, indicating the potential application for fatigue evaluation induced by all-out cycling exercise.
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http://dx.doi.org/10.1155/2018/9341215DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5926489PMC
October 2018

Genome-Wide Identification and Structural Analysis of bZIP Transcription Factor Genes in Brassica napus.

Genes (Basel) 2017 Oct 24;8(10). Epub 2017 Oct 24.

Chongqing Rapeseed Engineering Research Center, College of Agronomy and Biotechnology, Southwest University, Chongqing 400716, China.

The basic region/leucine zipper motif (bZIP) transcription factor family is one of the largest families of transcriptional regulators in plants. bZIP genes have been systematically characterized in some plants, but not in rapeseed (). In this study, we identified 247 genes in the rapeseed genome, which we classified into 10 subfamilies based on phylogenetic analysis of their deduced protein sequences. The genes were grouped into functional clades with genes with similar putative functions, indicating functional conservation. Genome mapping analysis revealed that the are distributed unevenly across all 19 chromosomes, and that some of these genes arose through whole-genome duplication and dispersed duplication events. All expression profiles of 247 bZIP genes were extracted from RNA-sequencing data obtained from 17 different . ZS11 tissues with 42 various developmental stages. These genes exhibited different expression patterns in various tissues, revealing that these genes are differentially regulated. Our results provide a valuable foundation for functional dissection of the different homologs in . and its parental lines and for molecular breeding studies of genes in . .
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http://dx.doi.org/10.3390/genes8100288DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5664138PMC
October 2017

Self-Forming Interlocking Interfaces on the Immiscible Polymer Bilayers via Gelation-Mediated Phase Separation.

Macromol Rapid Commun 2017 Sep 10;38(17). Epub 2017 Jul 10.

INM - Leibniz Institute for New Materials, Campus D2 2, 66123, Saarbrücken, Germany.

Gelation-mediated phase separation is applied to prepare immiscible polymer bilayer films with an interlocking interface structure. Polymer systems consisting of copolymer of urea and polydimethylsiloxane and epoxy are selected to demonstrate the feasibility. When the epoxy fraction exceeds 25 wt%, well-defined bilayer structures self-form by a one-pot casting method in which the phase separation state is fixed by an evaporation-induced gelation. Microscopy studies of the resulting bilayers clearly reveal that interlocking structures form during the bilayer films construct. The interlocking structures lead to an enhanced interfacial adhesion and higher fracture energy. The current strategy might offer a facile way to in situ create an interlocking interface between immiscible polymer systems.
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http://dx.doi.org/10.1002/marc.201700206DOI Listing
September 2017

Regulation of Smoothened Trafficking and Hedgehog Signaling by the SUMO Pathway.

Dev Cell 2016 11 13;39(4):438-451. Epub 2016 Oct 13.

Department of Developmental Biology, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390, USA; Department of Molecular Biology, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390, USA; Department of Pharmacology, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390, USA. Electronic address:

Hedgehog (Hh) signaling plays a central role in development and diseases. Hh activates its signal transducer and GPCR-family protein Smoothened (Smo) by inducing Smo phosphorylation, but whether Smo is activated through other post-translational modifications remains unexplored. Here we show that sumoylation acts in parallel with phosphorylation to promote Smo cell-surface expression and Hh signaling. We find that Hh stimulates Smo sumoylation by dissociating it from a desumoylation enzyme Ulp1. Sumoylation of Smo in turn recruits a deubiquitinase UBPY/USP8 to antagonize Smo ubiquitination and degradation, leading to its cell-surface accumulation and elevated Hh pathway activity. We also provide evidence that Shh stimulates sumoylation of mammalian Smo (mSmo) and that sumoylation promotes ciliary localization of mSmo and Shh pathway activity. Our findings reveal a conserved mechanism whereby the SUMO pathway promotes Hh signaling by regulating Smo subcellular localization and shed light on how sumoylation regulates membrane protein trafficking.
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http://dx.doi.org/10.1016/j.devcel.2016.09.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5121078PMC
November 2016

Free-Standing Conducting Polymer Films for High-Performance Energy Devices.

Angew Chem Int Ed Engl 2016 Jan 2;55(3):979-82. Epub 2015 Dec 2.

Wuhan National Laboratory for Optoelectronics and School of Optical and Electronic Information, Huazhong University of Science and Technology, Wuhan, 430074, China.

Thick, uniform, easily processed, highly conductive polymer films are desirable as electrodes for solar cells as well as polymer capacitors. Here, a novel scalable strategy is developed to prepare highly conductive thick poly(3,4-ethylenedioxythiophene):polystyrene sulfonate (HCT-PEDOT:PSS) films with layered structure that display a conductivity of 1400 S cm(-1) and a low sheet resistance of 0.59 ohm sq(-1). Organic solar cells with laminated HCT-PEDOT:PSS exhibit a performance comparable to the reference devices with vacuum-deposited Ag top electrodes. More importantly, the HCT-PEDOT:PSS film delivers a specific capacitance of 120 F g(-1) at a current density of 0.4 A g(-1). All-solid-state flexible symmetric supercapacitors with the HCT-PEDOT:PSS films display a high volumetric energy density of 6.80 mWh cm(-3) at a power density of 100 mW cm(-3) and 3.15 mWh cm(-3) at a very high power density of 16160 mW cm(-3) that outperforms previous reported solid-state supercapacitors based on PEDOT materials.
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http://dx.doi.org/10.1002/anie.201509033DOI Listing
January 2016

Influence of calcination temperature on the properties of titanium oxide sulfur recovery catalysts.

J Nanosci Nanotechnol 2014 Sep;14(9):7181-8

To study the effect of calcination temperatures on the sulfur recovery catalysts, titanium oxide (TiO2), as sulfur recovery catalysts, were treated at four calcination temperatures of 300 degrees C, 500 degrees C, 700 degrees C and 900 degrees C. The structure of the catalysts were characterized by X-ray powder diffraction (XRD), Raman, transmission electron microscopy (TEM), Scanning electron microscopy (SEM), temperature thermogravimetry (TG) and differential scanning calorimetry (DSC). The results showed that with the calcination temperature increasing, the particle size of the TiO2 catalysts increases but the surface area and total pore volume decrease. The extent of reduction was more serious after calcination at 500 degrees C. Rutile phase were formed at calcination temperature about 700 degrees C. On the basis of these results, a scheme for the change of TiO2 with increasing calcination temperatures was proposed. The Claus catalytic activity of the TiO2 catalysts was evaluated in the traditional conditions. It was found that the Claus catalytic activity, which decreased a little when the calcination temperature was no more than 500 degrees C but much once the calcination temperature was more than 500 degrees C, was not only related to the surface area and pore volume, but also the phase of the TiO2. The activity of rutile was less than the anatase and a possible reaction pathway to reveal this mechanism was proposed.
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http://dx.doi.org/10.1166/jnn.2014.8953DOI Listing
September 2014

A lithium anode protection guided highly-stable lithium-sulfur battery.

Chem Commun (Camb) 2014 Nov;50(91):14209-12

CAS Key Laboratory of Materials for Energy Conversion, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai, 200050, China.

A Li3N protection layer is fabricated on the surface of a Li anode by an in situ method to suppress the shuttle effect on the basis of anode protection. The discharge capacity is retained at 773 mA h g(-1) after 500 cycles with an average coulombic efficiency of 92.3% in the electrolyte without LiNO3, while the sulfur loading of the simple sulfur cathode was 2.5-3 mg cm(-2).
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http://dx.doi.org/10.1039/c4cc05535gDOI Listing
November 2014

A shuttle effect free lithium sulfur battery based on a hybrid electrolyte.

Phys Chem Chem Phys 2014 Oct 8;16(39):21225-9. Epub 2014 Sep 8.

CAS Key Laboratory of Materials for Energy Conversion, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai 200050, P. R. China.

A room temperature hybrid electrolyte based lithium-sulfur cell was successfully cycled with an excellent coulombic efficiency of 100%. The initial discharge specific capacities of up to 1528 mA h g(-1), 1386 mA h g(-1) and 1341 mA h g(-1), respectively, at C/20, C/5 and C/2 rates were realized and remained at 720 mA h g(-1) after 40 cycles at the C/5 rate.
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http://dx.doi.org/10.1039/c4cp03694hDOI Listing
October 2014

Hedgehog induces formation of PKA-Smoothened complexes to promote Smoothened phosphorylation and pathway activation.

Sci Signal 2014 Jul 1;7(332):ra62. Epub 2014 Jul 1.

Department of Developmental Biology, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390, USA. Department of Pharmacology, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390, USA.

Hedgehog (Hh) is a secreted glycoprotein that binds its receptor Patched to activate the G protein (heterotrimeric guanine nucleotide-binding protein)-coupled receptor-like protein Smoothened (Smo). In Drosophila, protein kinase A (PKA) phosphorylates and activates Smo in cells stimulated with Hh. In unstimulated cells, PKA phosphorylates and inhibits the transcription factor Cubitus interruptus (Ci). We found that in cells exposed to Hh, the catalytic subunit of PKA (PKAc) bound to the juxtamembrane region of the carboxyl terminus of Smo. PKA-mediated phosphorylation of Smo further enhanced its association with PKAc to form stable kinase-substrate complexes that promoted the PKA-mediated transphosphorylation of Smo dimers. We identified multiple basic residues in the carboxyl terminus of Smo that were required for interaction with PKAc, Smo phosphorylation, and Hh pathway activation. Hh induced a switch from the association of PKAc with a cytosolic complex of Ci and the kinesin-like protein Costal2 (Cos2) to a membrane-bound Smo-Cos2 complex. Thus, our study uncovers a previously uncharacterized mechanism for regulation of PKA activity and demonstrates that the signal-regulated formation of kinase-substrate complexes plays a central role in Hh signal transduction.
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http://dx.doi.org/10.1126/scisignal.2005414DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4621970PMC
July 2014

Sonic Hedgehog dependent phosphorylation by CK1α and GRK2 is required for ciliary accumulation and activation of smoothened.

PLoS Biol 2011 Jun 14;9(6):e1001083. Epub 2011 Jun 14.

Department of Developmental Biology, University of Texas Southwestern Medical Center at Dallas, United States of America.

Hedgehog (Hh) signaling regulates embryonic development and adult tissue homeostasis through the GPCR-like protein Smoothened (Smo), but how vertebrate Smo is activated remains poorly understood. In Drosophila, Hh dependent phosphorylation activates Smo. Whether this is also the case in vertebrates is unclear, owing to the marked sequence divergence between vertebrate and Drosophila Smo (dSmo) and the involvement of primary cilia in vertebrate Hh signaling. Here we demonstrate that mammalian Smo (mSmo) is activated through multi-site phosphorylation of its carboxyl-terminal tail by CK1α and GRK2. Phosphorylation of mSmo induces its active conformation and simultaneously promotes its ciliary accumulation. We demonstrate that graded Hh signals induce increasing levels of mSmo phosphorylation that fine-tune its ciliary localization, conformation, and activity. We show that mSmo phosphorylation is induced by its agonists and oncogenic mutations but is blocked by its antagonist cyclopamine, and efficient mSmo phosphorylation depends on the kinesin-II ciliary motor. Furthermore, we provide evidence that Hh signaling recruits CK1α to initiate mSmo phosphorylation, and phosphorylation further increases the binding of CK1α and GRK2 to mSmo, forming a positive feedback loop that amplifies and/or sustains mSmo phosphorylation. Hence, despite divergence in their primary sequences and their subcellular trafficking, mSmo and dSmo employ analogous mechanisms for their activation.
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http://dx.doi.org/10.1371/journal.pbio.1001083DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3114773PMC
June 2011