Guojun Bu

Guojun Bu

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Guojun Bu

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Apolipoprotein E and Alzheimer disease: pathobiology and targeting strategies.

Nat Rev Neurol 2019 Sep 31;15(9):501-518. Epub 2019 Jul 31.

Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA.

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http://dx.doi.org/10.1038/s41582-019-0228-7DOI Listing
September 2019

RPS23RG1 Is Required for Synaptic Integrity and Rescues Alzheimer's Disease-Associated Cognitive Deficits.

Biol Psychiatry 2019 Aug 25;86(3):171-184. Epub 2018 Aug 25.

Fujian Provincial Key Laboratory of Neurodegenerative Disease and Aging Research, Institute of Neuroscience, Medical College of Xiamen University, Xiamen, Fujian, China. Electronic address:

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http://dx.doi.org/10.1016/j.biopsych.2018.08.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6389446PMC
August 2019

Differential Effects of Extracellular Vesicles of Lineage-Specific Human Pluripotent Stem Cells on the Cellular Behaviors of Isogenic Cortical Spheroids.

Cells 2019 Aug 28;8(9). Epub 2019 Aug 28.

Department of Chemical and Biomedical Engineering, FAMU-FSU College of Engineering, Florida State University, Tallahassee, FL 32310, USA.

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http://dx.doi.org/10.3390/cells8090993DOI Listing
August 2019

Author Correction: Soluble TREM2 ameliorates pathological phenotypes by modulating microglial functions in an Alzheimer's disease model.

Nat Commun 2019 Jul 2;10(1):2923. Epub 2019 Jul 2.

Fujian Provincial Key Laboratory of Neurodegenerative Disease and Aging Research, Institute of Neuroscience, School of Medicine, Xiamen University, Xiamen, 361102, China.

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http://dx.doi.org/10.1038/s41467-019-10950-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6606585PMC
July 2019

A brain somatic RHEB doublet mutation causes focal cortical dysplasia type II.

Exp Mol Med 2019 Jul 23;51(7):84. Epub 2019 Jul 23.

Fujian Provincial Key Laboratory of Neurodegenerative Disease and Aging Research, Institute of Neuroscience, School of Medicine, Xiamen University, Xiamen, 361102, Fujian, China.

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http://dx.doi.org/10.1038/s12276-019-0277-4DOI Listing
July 2019

Soluble TREM2 ameliorates pathological phenotypes by modulating microglial functions in an Alzheimer's disease model.

Nat Commun 2019 03 25;10(1):1365. Epub 2019 Mar 25.

Fujian Provincial Key Laboratory of Neurodegenerative Disease and Aging Research, Institute of Neuroscience, School of Medicine, Xiamen University, Xiamen, 361102, China.

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http://dx.doi.org/10.1038/s41467-019-09118-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6433910PMC
March 2019

5-HT3 Antagonist Ondansetron Increases apoE Secretion by Modulating the LXR-ABCA1 Pathway.

Int J Mol Sci 2019 Mar 25;20(6). Epub 2019 Mar 25.

Department of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA.

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http://dx.doi.org/10.3390/ijms20061488DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6471172PMC
March 2019

Compensatory Mechanisms Modulate the Neuronal Excitability in a Kainic Acid-Induced Epilepsy Mouse Model.

Front Neural Circuits 2018 29;12:48. Epub 2018 Jun 29.

Fujian Provincial Key Laboratory of Neurodegenerative Disease and Aging Research, Institute of Neuroscience, Medical College, Xiamen University, Xiamen, China.

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http://dx.doi.org/10.3389/fncir.2018.00048DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6034068PMC
February 2019

Menin Deficiency Leads to Depressive-like Behaviors in Mice by Modulating Astrocyte-Mediated Neuroinflammation.

Neuron 2018 11 13;100(3):551-563.e7. Epub 2018 Sep 13.

Fujian Provincial Key Laboratory of Neurodegenerative Disease and Aging Research, Institute of Neuroscience, College of Medicine, Xiamen University, Xiamen, Fujian 361102, P.R. China. Electronic address:

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http://dx.doi.org/10.1016/j.neuron.2018.08.031DOI Listing
November 2018

ε4 is associated with severity of Lewy body pathology independent of Alzheimer pathology.

Neurology 2018 09 24;91(12):e1182-e1195. Epub 2018 Aug 24.

From the Department of Neuroscience (D.W.D., M.E.M., A.I.S., R.W., N.E.-T., G.B., O.A.R.), Division of Biomedical Statistics and Informatics (M.G.H., N.N.D.), and Departments of Neurology (J.A.v.G., R.J.U., Z.K.W., N.E.-T., N.R.G.-R.) and Psychiatry and Psychology (T.J.F.), Mayo Clinic, Jacksonville, FL; and Department of Neurology (D.S.K., R.C.P., B.F.B.), Mayo Clinic, Rochester, MN.

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http://dx.doi.org/10.1212/WNL.0000000000006212DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6161556PMC
September 2018

Cyclin-dependent kinase 5-mediated phosphorylation of chloride intracellular channel 4 promotes oxidative stress-induced neuronal death.

Cell Death Dis 2018 Sep 20;9(10):951. Epub 2018 Sep 20.

Fujian Provincial Key Laboratory of Neurodegenerative Disease and Aging Research, Institute of Neuroscience, Medical College, Xiamen University, 361005, Xiamen, Fujian, China.

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http://dx.doi.org/10.1038/s41419-018-0983-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6147799PMC
September 2018

Association study between multiple system atrophy and TREM2 p.R47H.

Neurol Genet 2018 Aug 1;4(4):e257. Epub 2018 Aug 1.

Department of Neuroscience (K.O., S.K., Y.A.M, C.L., O.L.-B., R.L.W., A.I.S., S.F., S.G.Y., G.B., D.W.D., O.A.R.), Mayo Clinic, Jacksonville, FL; Department of Neurology (K.O.), Juntendo University Shizuoka Hospital, Izunokunishi, Shizuoka, Japan; Division of Biomedical Statistics and Informatics (M.G.H., E.R.V), Mayo Clinic, Jacksonville, FL; Department of Neurology (R.J.U., J.A.v.G., W.P.C., Z.K.W.), Mayo Clinic, Jacksonville, FL; Department of Neurology (P.A.L., W.S.), Mayo Clinic, Rochester, MN; Mayo Graduate School (O.A.R.), Neurobiology of Disease, Jacksonville, FL; and Department of Clinical Genomics (O.A.R.), Jacksonville, FL.

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http://dx.doi.org/10.1212/NXG.0000000000000257DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6089688PMC
August 2018

Modeling Neurodegenerative Microenvironment Using Cortical Organoids Derived from Human Stem Cells.

Tissue Eng Part A 2018 07 27;24(13-14):1125-1137. Epub 2018 Feb 27.

1 Department of Chemical and Biomedical Engineering, FAMU-FSU College of Engineering, Florida State University , Tallahassee, Florida.

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http://dx.doi.org/10.1089/ten.TEA.2017.0423DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6033307PMC
July 2018

A novel link between trafficking and Lewy body disorders.

Lancet Neurol 2018 07 7;17(7):571-573. Epub 2018 Jun 7.

Department of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA.

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http://dx.doi.org/10.1016/S1474-4422(18)30214-XDOI Listing
July 2018

Neuron-Specific Menin Deletion Leads to Synaptic Dysfunction and Cognitive Impairment by Modulating p35 Expression.

Cell Rep 2018 07;24(3):701-712

Fujian Provincial Key Laboratory of Neurodegenerative Disease and Aging Research, Institute of Neuroscience, Medical College, Xiamen University, Xiamen, Fujian 361102, China. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2018.06.055DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6434950PMC
July 2018

AMPA-ergic regulation of amyloid-β levels in an Alzheimer's disease mouse model.

Mol Neurodegener 2018 05 15;13(1):22. Epub 2018 May 15.

Department of Neurology, Knight Alzheimer's Disease Research Center, Hope Center for Neurological Disorders, Washington University School of Medicine, Campus Box 8111, 660 South Euclid Avenue, St. Louis, MO, 63110, USA.

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http://dx.doi.org/10.1186/s13024-018-0256-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5952376PMC
May 2018

TREM2 Is a Receptor for β-Amyloid that Mediates Microglial Function.

Neuron 2018 03;97(5):1023-1031.e7

Neuroscience Initiative, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037, USA; Fujian Provincial Key Laboratory of Neurodegenerative Disease and Aging Research, Institute of Neuroscience, College of Medicine, Xiamen University, Xiamen, Fujian 361102, China. Electronic address:

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http://dx.doi.org/10.1016/j.neuron.2018.01.031DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5889092PMC
March 2018

Amyloid-beta modulates microglial responses by binding to the triggering receptor expressed on myeloid cells 2 (TREM2).

Mol Neurodegener 2018 03 27;13(1):15. Epub 2018 Mar 27.

Fujian Provincial Key Laboratory of Neurodegenerative Disease and Aging Research, Institute of Neuroscience, Medical College, Xiamen University, Xiamen, 361102, China.

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http://dx.doi.org/10.1186/s13024-018-0247-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5870375PMC
March 2018

Apolipoprotein E, Receptors, and Modulation of Alzheimer's Disease.

Biol Psychiatry 2018 02 14;83(4):347-357. Epub 2017 Mar 14.

Department of Neuroscience, Mayo Clinic, Jacksonville, Florida; Fujian Provincial Key Laboratory of Neurodegenerative Disease and Aging Research, Institute of Neuroscience, College of Medicine, Xiamen University, Xiamen, Fujian, China. Electronic address:

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http://dx.doi.org/10.1016/j.biopsych.2017.03.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5599322PMC
February 2018

Pericyte implantation in the brain enhances cerebral blood flow and reduces amyloid-β pathology in amyloid model mice.

Exp Neurol 2018 02 26;300:13-21. Epub 2017 Oct 26.

Department of Neuroscience, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL 32224, USA. Electronic address:

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http://dx.doi.org/10.1016/j.expneurol.2017.10.023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5745278PMC
February 2018

Progranulin-mediated deficiency of cathepsin D results in FTD and NCL-like phenotypes in neurons derived from FTD patients.

Hum Mol Genet 2017 12;26(24):4861-4872

The Ken & Ruth Davee Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.

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http://dx.doi.org/10.1093/hmg/ddx364DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5886207PMC
December 2017

ApoE4 Accelerates Early Seeding of Amyloid Pathology.

Neuron 2017 Dec;96(5):1024-1032.e3

Department of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA; Fujian Provincial Key Laboratory of Neurodegenerative Disease and Aging Research, Institute of Neuroscience, College of Medicine, Xiamen University, Xiamen, Fujian 361005, China. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S08966273173106
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http://dx.doi.org/10.1016/j.neuron.2017.11.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5948105PMC
December 2017

Intracellular trafficking of TREM2 is regulated by presenilin 1.

Exp Mol Med 2017 12 1;49(12):e405. Epub 2017 Dec 1.

Neuroscience Initiative, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA.

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http://dx.doi.org/10.1038/emm.2017.200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5750471PMC
December 2017

Synaptic Adhesion Molecule Pcdh-γC5 Mediates Synaptic Dysfunction in Alzheimer's Disease.

J Neurosci 2017 09 21;37(38):9259-9268. Epub 2017 Aug 21.

Fujian Provincial Key Laboratory of Neurodegenerative Disease and Aging Research, Institute of Neuroscience, College of Medicine, Xiamen University, Xiamen 361005 Fujian, China,

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http://dx.doi.org/10.1523/JNEUROSCI.1051-17.2017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5607468PMC
September 2017

Apolipoprotein E4 Impairs Neuronal Insulin Signaling by Trapping Insulin Receptor in the Endosomes.

Neuron 2017 Sep;96(1):115-129.e5

Department of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA; Fujian Provincial Key Laboratory of Neurodegenerative Disease and Aging Research, Institute of Neuroscience, College of Medicine, Xiamen University, Xiamen, Fujian, 361005, China. Electronic address:

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http://dx.doi.org/10.1016/j.neuron.2017.09.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5621659PMC
September 2017

The Neuron-Specific Protein TMEM59L Mediates Oxidative Stress-Induced Cell Death.

Mol Neurobiol 2017 08 21;54(6):4189-4200. Epub 2016 Jun 21.

Fujian Provincial Key Laboratory of Neurodegenerative Disease and Aging Research, Institute of Neuroscience, College of Medicine, Collaborative Innovation Center for Brain Science, Xiamen University, Xiamen, Fujian, 361102, China.

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http://dx.doi.org/10.1007/s12035-016-9997-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5288309PMC
August 2017

Multivalent bi-specific nanobioconjugate engager for targeted cancer immunotherapy.

Nat Nanotechnol 2017 08 1;12(8):763-769. Epub 2017 May 1.

Department of Neurosurgery, Mayo Clinic College of Medicine, 4500 San Pablo Road, Jacksonville, Florida 32224, USA.

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http://www.nature.com/doifinder/10.1038/nnano.2017.69
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http://dx.doi.org/10.1038/nnano.2017.69DOI Listing
August 2017

Role of LRP1 in the pathogenesis of Alzheimer's disease: evidence from clinical and preclinical studies.

J Lipid Res 2017 07 4;58(7):1267-1281. Epub 2017 Apr 4.

Department of Neuroscience, Mayo Clinic, Jacksonville, FL.

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http://dx.doi.org/10.1194/jlr.R075796DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5496044PMC
July 2017

TREM2/DAP12 Complex Regulates Inflammatory Responses in Microglia via the JNK Signaling Pathway.

Front Aging Neurosci 2017 21;9:204. Epub 2017 Jun 21.

Fujian Provincial Key Laboratory of Neurodegenerative Disease and Aging Research, Institute of Neuroscience, Medical College, Xiamen UniversityXiamen, China.

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http://dx.doi.org/10.3389/fnagi.2017.00204DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5478682PMC
June 2017

Subacute ibuprofen treatment rescues the synaptic and cognitive deficits in advanced-aged mice.

Neurobiol Aging 2017 05 9;53:112-121. Epub 2017 Feb 9.

Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA; Fujian Provincial Key Laboratory of Neurodegenerative Disease and Aging Research, Institute of Neuroscience, College of Medicine, Xiamen University, Xiamen, China; Neurobiology of Disease Graduate Program, Mayo Clinic College of Medicine, Jacksonville, FL, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neurobiolaging.2017.02.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5385269PMC
May 2017

Soluble TREM2 induces inflammatory responses and enhances microglial survival.

J Exp Med 2017 03 16;214(3):597-607. Epub 2017 Feb 16.

Fujian Provincial Key Laboratory of Neurodegenerative Disease and Aging Research, Institute of Neuroscience, Medical College, Xiamen University, Xiamen 361102, China

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http://dx.doi.org/10.1084/jem.20160844DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5339672PMC
March 2017

TREM2 Promotes Microglial Survival by Activating Wnt/β-Catenin Pathway.

J Neurosci 2017 02 11;37(7):1772-1784. Epub 2017 Jan 11.

Fujian Provincial Key Laboratory of Neurodegenerative Disease and Aging Research, Institute of Neuroscience, Medical College, Xiamen University, Xiamen 361102, China,

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http://www.jneurosci.org/lookup/doi/10.1523/JNEUROSCI.2459-1
Publisher Site
http://dx.doi.org/10.1523/JNEUROSCI.2459-16.2017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5320608PMC
February 2017

Peripheral apoE isoform levels in cognitively normal APOE ε3/ε4 individuals are associated with regional gray matter volume and cerebral glucose metabolism.

Alzheimers Res Ther 2017 Jan 30;9(1). Epub 2017 Jan 30.

Department of Neuroscience, Mayo Clinic College of Medicine, 4500 San Pablo Rd, Jacksonville, FL, 32224, USA.

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http://dx.doi.org/10.1186/s13195-016-0231-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5282900PMC
January 2017

TREMs in Alzheimer's disease: Genetic and clinical investigations.

Clin Chim Acta 2016 Dec 18;463:88-95. Epub 2016 Oct 18.

Fujian Provincial Key Laboratory of Neurodegenerative Disease and Aging Research, Institute of Neuroscience, Medical College, Xiamen University, Xiamen, Fujian, China.

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http://dx.doi.org/10.1016/j.cca.2016.10.022DOI Listing
December 2016

LRP1 modulates the microglial immune response via regulation of JNK and NF-κB signaling pathways.

J Neuroinflammation 2016 12 8;13(1):304. Epub 2016 Dec 8.

Institute of Neuroscience, Fujian Provincial Key Laboratory of Neurodegenerative Disease and Aging Research, Medical College, Xiamen University, Xiamen, 361102, China.

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http://dx.doi.org/10.1186/s12974-016-0772-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5146875PMC
December 2016

SNX27 Deletion Causes Hydrocephalus by Impairing Ependymal Cell Differentiation and Ciliogenesis.

J Neurosci 2016 12;36(50):12586-12597

Fujian Provincial Key Laboratory of Neurodegenerative Disease and Aging Research, Medical College and the Collaborative Innovation Center for Brain Science, Xiamen University, Xiamen 361102, China,

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http://dx.doi.org/10.1523/JNEUROSCI.1620-16.2016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5157104PMC
December 2016

VPS35 regulates cell surface recycling and signaling of dopamine receptor D1.

Neurobiol Aging 2016 10 21;46:22-31. Epub 2016 May 21.

Fujian Provincial Key Laboratory of Neurodegenerative Disease and Aging Research, Institute of Neuroscience, Collaborative Innovation Center for Brain Science, College of Medicine, Xiamen University, Xiamen, Fujian, China. Electronic address:

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http://dx.doi.org/10.1016/j.neurobiolaging.2016.05.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5018432PMC
October 2016

Quercetin stabilizes apolipoprotein E and reduces brain Aβ levels in amyloid model mice.

Neuropharmacology 2016 09 23;108:179-92. Epub 2016 Apr 23.

From the Fujian Provincial Key Laboratory of Neurodegenerative Disease and Aging Research, Institute of Neuroscience, College of Medicine, Xiamen University, Xiamen, Fujian, 361102, China. Electronic address:

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http://dx.doi.org/10.1016/j.neuropharm.2016.04.032DOI Listing
September 2016

Apolipoprotein E as a Therapeutic Target in Alzheimer's Disease: A Review of Basic Research and Clinical Evidence.

CNS Drugs 2016 09;30(9):773-89

Department of Neuroscience, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL, 32224, USA.

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http://dx.doi.org/10.1007/s40263-016-0361-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5526196PMC
September 2016

SNX15 Regulates Cell Surface Recycling of APP and Aβ Generation.

Mol Neurobiol 2016 08 27;53(6):3690-3701. Epub 2015 Jun 27.

Fujian Provincial Key Laboratory of Neurodegenerative Disease and Aging Research, Institute of Neuroscience, School of Pharmaceutical Sciences, College of Medicine, Xiamen University, Xiamen, 361102, China.

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http://link.springer.com/10.1007/s12035-015-9306-z
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http://dx.doi.org/10.1007/s12035-015-9306-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4691577PMC
August 2016

Demographic and Lifestyle Characteristics, but Not Apolipoprotein E Genotype, Are Associated with Intelligence among Young Chinese College Students.

PLoS One 2015 17;10(11):e0143157. Epub 2015 Nov 17.

Fujian Provincial Key Laboratory of Neurodegenerative Disease and Aging Research, Institute of Neuroscience, Medical College, Xiamen University, Xiamen, 361102, China.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0143157PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4648581PMC
June 2016

Opposing roles of the triggering receptor expressed on myeloid cells 2 and triggering receptor expressed on myeloid cells-like transcript 2 in microglia activation.

Neurobiol Aging 2016 06 16;42:132-41. Epub 2016 Mar 16.

Fujian Provincial Key Laboratory of Neurodegenerative Disease and Aging Research, Institute of Neuroscience, Medical College, Xiamen University, Xiamen, PR China; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA; Neurobiology of Disease Graduate Program, Mayo Clinic, Jacksonville, FL, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neurobiolaging.2016.03.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4857884PMC
June 2016

The role of APOE in cerebrovascular dysfunction.

Acta Neuropathol 2016 May 16;131(5):709-23. Epub 2016 Feb 16.

Department of Neuroscience, Mayo Clinic, Jacksonville, FL, 32224, USA.

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http://dx.doi.org/10.1007/s00401-016-1547-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4837016PMC
May 2016

Rapid in vivo measurement of β-amyloid reveals biphasic clearance kinetics in an Alzheimer's mouse model.

J Exp Med 2016 05 11;213(5):677-85. Epub 2016 Apr 11.

Department of Neurology, Hope Center for Neurological Disorders, Knight Alzheimer's Disease Research Center, Washington University School of Medicine, St. Louis, MO 63110

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http://dx.doi.org/10.1084/jem.20151428DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4854730PMC
May 2016

Vascular Cell Senescence Contributes to Blood-Brain Barrier Breakdown.

Stroke 2016 Apr 16;47(4):1068-77. Epub 2016 Feb 16.

From the Departments of Neuroscience (Y.Y., M.T., C-C.L., G.B., T.K.) and Neurology (T.G.B.), Mayo Clinic, Jacksonville, FL; and Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, MN (D.J.B., J.M.v.D.).

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http://stroke.ahajournals.org/content/early/2016/02/16/STROK
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http://stroke.ahajournals.org/lookup/doi/10.1161/STROKEAHA.1
Publisher Site
http://dx.doi.org/10.1161/STROKEAHA.115.010835DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4811685PMC
April 2016

Rescuing effects of RXR agonist bexarotene on aging-related synapse loss depend on neuronal LRP1.

Exp Neurol 2016 Mar 11;277:1-9. Epub 2015 Dec 11.

Department of Neuroscience, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL 32224, USA. Electronic address:

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http://dx.doi.org/10.1016/j.expneurol.2015.12.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4761336PMC
March 2016

Appoptosin interacts with mitochondrial outer-membrane fusion proteins and regulates mitochondrial morphology.

J Cell Sci 2016 Mar 26;129(5):994-1002. Epub 2016 Jan 26.

Fujian Provincial Key Laboratory of Neurodegenerative Disease and Aging Research, Institute of Neuroscience, School of Pharmaceutical Sciences, College of Medicine, Collaborative Innovation Center for Brain Science, Xiamen University, Xiamen, Fujian 361102, China

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http://dx.doi.org/10.1242/jcs.176792DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4813315PMC
March 2016

Implications of GABAergic Neurotransmission in Alzheimer's Disease.

Front Aging Neurosci 2016 23;8:31. Epub 2016 Feb 23.

Fujian Provincial Key Laboratory of Neurodegenerative Disease and Aging Research, Institute of Neuroscience, College of Medicine, Xiamen UniversityXiamen, China; The Interdepartmental Program of Translational Biology and Molecular Medicine, Huffington Center on Aging, Baylor College of MedicineHouston, TX, USA.

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http://dx.doi.org/10.3389/fnagi.2016.00031DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4763334PMC
March 2016

Neuronal heparan sulfates promote amyloid pathology by modulating brain amyloid-β clearance and aggregation in Alzheimer's disease.

Sci Transl Med 2016 Mar;8(332):332ra44

Department of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA. Fujian Provincial Key Laboratory of Neurodegenerative Disease and Aging Research, Institute of Neuroscience, College of Medicine, Xiamen University, Xiamen, Fujian 361100, China.

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http://stm.sciencemag.org/content/scitransmed/8/332/332ra44.
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http://stm.sciencemag.org/cgi/doi/10.1126/scitranslmed.aad36
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http://dx.doi.org/10.1126/scitranslmed.aad3650DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5512541PMC
March 2016

MiR-219 Protects Against Seizure in the Kainic Acid Model of Epilepsy.

Mol Neurobiol 2016 Jan 15;53(1):1-7. Epub 2014 Nov 15.

Department of Neurology, Affiliated Zhongshan Hospital, Xiamen University, Xiamen, 361004, Fujian Province, China.

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http://dx.doi.org/10.1007/s12035-014-8981-5DOI Listing
January 2016

A rapid and cost-effective method for genotyping apolipoprotein E gene polymorphism.

Mol Neurodegener 2016 Jan 12;11. Epub 2016 Jan 12.

Fujian Provincial Key Laboratory of Neurodegenerative Disease and Aging Research, Institute of Neuroscience, Medical College, Xiamen University, Xiamen, 361102, China.

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http://dx.doi.org/10.1186/s13024-016-0069-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4710020PMC
January 2016

Heparan sulfate proteoglycans mediate Aβ-induced oxidative stress and hypercontractility in cultured vascular smooth muscle cells.

Mol Neurodegener 2016 Jan 22;11. Epub 2016 Jan 22.

Department of Neurological Surgery, Washington University School of Medicine, Hope Center Program on Protein Aggregation and Neurodegeneration, Charles F. and Joanne Knight Alzheimer's Disease Research Center, Campus Box 8057, 660 South Euclid Avenue, St. Louis, Missouri, 63110, USA.

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http://dx.doi.org/10.1186/s13024-016-0073-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4722750PMC
January 2016

Apolipoprotein E epsilon 2 allele and low serum cholesterol as risk factors for gastric cancer in a Chinese Han population.

Sci Rep 2016 Jan 28;6:19930. Epub 2016 Jan 28.

Fujian Provincial Key Laboratory of Neurodegenerative Disease and Aging Research, Institute of Neuroscience, Medical College, Xiamen University, Xiamen 361102, China.

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http://dx.doi.org/10.1038/srep19930DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4730152PMC
January 2016

Low-density lipoprotein receptor-related protein 1 (LRP1) regulates the stability and function of GluA1 α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) receptor in neurons.

PLoS One 2014 12;9(12):e113237. Epub 2014 Dec 12.

Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, United States of America; Fujian Provincial Key Laboratory of Neurodegenerative Disease and Aging Research, Institute of Neuroscience, College of Medicine, Xiamen University, Xiamen, China.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0113237PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4264746PMC
October 2015

Apolipoprotein E Is a Ligand for Triggering Receptor Expressed on Myeloid Cells 2 (TREM2).

J Biol Chem 2015 Oct 15;290(43):26043-50. Epub 2015 Sep 15.

From the Department of Neuroscience and the Fujian Provincial Key Laboratory of Neurodegenerative Disease and Aging Research, Institute of Neuroscience, College of Medicine, Xiamen University, Xiamen, Fujian 361005, China the Neurobiology of Disease Graduate Program, Mayo Clinic, Jacksonville, Florida 32224 and

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http://dx.doi.org/10.1074/jbc.M115.679043DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4646257PMC
October 2015

Genetics ignite focus on microglial inflammation in Alzheimer's disease.

Mol Neurodegener 2015 Oct 5;10:52. Epub 2015 Oct 5.

Department of Physiology and Sanders-Brown Center on Aging, University of Kentucky, 800 S. Limestone St, Lexington, KY, 40536, USA.

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http://www.molecularneurodegeneration.com/content/pdf/s13024
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http://dx.doi.org/10.1186/s13024-015-0048-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4595327PMC
October 2015

Detection and enumeration of circulating tumor cells based on their invasive property.

Oncotarget 2015 Sep;6(29):27304-11

Department of Clinical Cancer Prevention, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.

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http://dx.doi.org/10.18632/oncotarget.4454DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4694991PMC
September 2015

Appoptosin-Mediated Caspase Cleavage of Tau Contributes to Progressive Supranuclear Palsy Pathogenesis.

Neuron 2015 Sep;87(5):963-75

Fujian Provincial Key Laboratory of Neurodegenerative Disease and Aging Research, Institute of Neuroscience, College of Medicine, Xiamen University, Xiamen, Fujian 361102, China; Degenerative Diseases Program, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neuron.2015.08.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4575284PMC
September 2015

TREM2 in CNS homeostasis and neurodegenerative disease.

Mol Neurodegener 2015 Sep 4;10:43. Epub 2015 Sep 4.

Department of Neuroscience, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL, 32224, USA.

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http://dx.doi.org/10.1186/s13024-015-0040-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4560063PMC
September 2015

DAP12 Stabilizes the C-terminal Fragment of the Triggering Receptor Expressed on Myeloid Cells-2 (TREM2) and Protects against LPS-induced Pro-inflammatory Response.

J Biol Chem 2015 Jun 8;290(25):15866-77. Epub 2015 May 8.

From the Fujian Provincial Key Laboratory of Neurodegenerative Disease and Aging Research, Institute of Neuroscience, Medical College, Xiamen University, Xiamen 361102, PR China, Department of Neuroscience, Mayo Clinic, Jacksonville, Florida 32224

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http://dx.doi.org/10.1074/jbc.M115.645986DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4505493PMC
June 2015

Very low density lipoprotein receptor regulates dendritic spine formation in a RasGRF1/CaMKII dependent manner.

Biochim Biophys Acta 2015 May 31;1853(5):904-17. Epub 2015 Jan 31.

Department of Neuroscience, Georgetown University Medical Center, Washington, DC 20057, USA; Department of Neurology, Georgetown University Medical Center, Washington, DC 20057, USA. Electronic address:

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http://dx.doi.org/10.1016/j.bbamcr.2015.01.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4580245PMC
May 2015

Apolipoprotein E Inhibits Cerebrovascular Pericyte Mobility through a RhoA Protein-mediated Pathway.

J Biol Chem 2015 May 22;290(22):14208-17. Epub 2015 Apr 22.

From the Department of Neuroscience, Mayo Clinic, Jacksonville, Florida 32224

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http://dx.doi.org/10.1074/jbc.M114.625251DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4447989PMC
May 2015

Neuronal LRP1 regulates glucose metabolism and insulin signaling in the brain.

J Neurosci 2015 Apr;35(14):5851-9

Department of Neuroscience, Mayo Clinic, Jacksonville, Florida 32224, and Fujian Provincial Key Laboratory of Neurodegenerative Disease and Aging Research, Institute of Neuroscience, College of Medicine, Xiamen University, Xiamen, Fujian 361005, China

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http://dx.doi.org/10.1523/JNEUROSCI.5180-14.2015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4388937PMC
April 2015

Role of copper and the copper-related protein CUTA in mediating APP processing and Aβ generation.

Neurobiol Aging 2015 Mar 11;36(3):1310-5. Epub 2014 Dec 11.

Fujian Provincial Key Laboratory of Neurodegenerative Disease and Aging Research, Institute of Neuroscience, College of Medicine, Xiamen University, Xiamen, China. Electronic address:

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http://dx.doi.org/10.1016/j.neurobiolaging.2014.12.005DOI Listing
March 2015

Cyclin-dependent kinase 5 decreases in gastric cancer and its nuclear accumulation suppresses gastric tumorigenesis.

Clin Cancer Res 2015 Mar 21;21(6):1419-28. Epub 2015 Jan 21.

Fujian Provincial Key Laboratory of Neurodegenerative Disease and Aging Research, Institute of Neuroscience, College of Medicine, Xiamen University, Xiamen, Fujian China. Cancer Research Center, Xiamen University, Xiamen, Fujian, China.

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http://dx.doi.org/10.1158/1078-0432.CCR-14-1950DOI Listing
March 2015

The roles of Cdk5-mediated subcellular localization of FOXO1 in neuronal death.

J Neurosci 2015 Feb;35(6):2624-35

Fujian Provincial Key Laboratory of Neurodegenerative Disease and Aging Research, Institute of Neuroscience, Medical College, Xiamen University, Xiamen, 361005, Fujian Province, China,

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http://dx.doi.org/10.1523/JNEUROSCI.3051-14.2015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4582140PMC
February 2015

α(2A) adrenergic receptor promotes amyloidogenesis through disrupting APP-SorLA interaction.

Proc Natl Acad Sci U S A 2014 Dec 17;111(48):17296-301. Epub 2014 Nov 17.

Department of Cell, Developmental and Integrative Biology, University of Alabama at Birmingham, Birmingham, AL 35294;

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http://dx.doi.org/10.1073/pnas.1409513111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4260556PMC
December 2014

Sorting nexin 27 regulates Aβ production through modulating γ-secretase activity.

Cell Rep 2014 Nov 23;9(3):1023-33. Epub 2014 Oct 23.

Fujian Provincial Key Laboratory of Neurodegenerative Disease and Aging Research, Institute of Neuroscience, Medical College, Xiamen University, Xiamen 361005, China; Degenerative Disease Research Program, Center for Neuroscience, Aging, and Stem Cell Research, Sanford-Burnham Medical Research Institute, La Jolla, CA 92037, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2014.09.037DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4328673PMC
November 2014

Tyrosine-based signal mediates LRP6 receptor endocytosis and desensitization of Wnt/β-catenin pathway signaling.

J Biol Chem 2014 Oct 20;289(40):27562-70. Epub 2014 Aug 20.

From the Fujian Provincial Key Laboratory of Neurodegenerative Disease and Aging Research, Institute of Neuroscience, College of Medicine, Xiamen University, Xiamen, Fujian 361005, China and the Department of Neuroscience, Mayo Clinic, Jacksonville, Florida 32224

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http://dx.doi.org/10.1074/jbc.M113.533927DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4183796PMC
October 2014

Deficiency in LRP6-mediated Wnt signaling contributes to synaptic abnormalities and amyloid pathology in Alzheimer's disease.

Neuron 2014 Oct 18;84(1):63-77. Epub 2014 Sep 18.

Department of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA; Neurobiology of Disease Graduate Program, Mayo Clinic College of Medicine, Jacksonville, FL 32224, USA; Fujian Provincial Key Laboratory of Neurodegenerative Disease and Aging Research, Institute of Neuroscience, College of Medicine, Xiamen University, Xiamen, Fujian, China. Electronic address:

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http://dx.doi.org/10.1016/j.neuron.2014.08.048DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4199382PMC
October 2014

Dysregulation of protein trafficking in neurodegeneration.

Mol Neurodegener 2014 Aug 25;9:31. Epub 2014 Aug 25.

Fujian Provincial Key Laboratory of Neurodegenerative Disease and Aging Research, Institute of Neuroscience, College of Medicine, Xiamen University, Xiamen, Fujian 361102, China.

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http://dx.doi.org/10.1186/1750-1326-9-31DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4237948PMC
August 2014

The low-density lipoprotein receptor-related protein 1 and amyloid-β clearance in Alzheimer's disease.

Front Aging Neurosci 2014 20;6:93. Epub 2014 May 20.

Department of Neuroscience, Mayo Clinic, Jacksonville FL, USA.

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http://dx.doi.org/10.3389/fnagi.2014.00093DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4033011PMC
June 2014