Guo-Qiang Chen

Guo-Qiang Chen

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Guo-Qiang Chen

Publications by authors named "Guo-Qiang Chen"

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Microbial engineering for easy downstream processing.

Biotechnol Adv 2019 Nov 6;37(6):107365. Epub 2019 Mar 6.

Center for Synthetic and Systems Biology, School of Life Sciences, Tsinghua University, Beijing 100084, China; Department of Chemical Engineering, Tsinghua University, Beijing 100084, China. Electronic address:

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http://dx.doi.org/10.1016/j.biotechadv.2019.03.004DOI Listing
November 2019

Highly Efficient Fluorescent Material Based on Rare-Earth-Modified Polyhydroxyalkanoates.

Biomacromolecules 2019 Sep 23;20(9):3233-3241. Epub 2019 Jan 23.

Center of Synthetic and Systems Biology, School of Life Science, Tsinghua-Peking Center for Life Sciences, Tsinghua University , Beijing 100084 , China.

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http://dx.doi.org/10.1021/acs.biomac.8b01722DOI Listing
September 2019

Next-Generation Industrial Biotechnology-Transforming the Current Industrial Biotechnology into Competitive Processes.

Biotechnol J 2019 Sep 28;14(9):e1800437. Epub 2019 May 28.

Ministry of Education Key Laboratory for Bioinformatics, School of Life Sciences, Tsinghua University, New Biology Building, 100084, Beijing, China.

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http://dx.doi.org/10.1002/biot.201800437DOI Listing
September 2019

Synthesis and Characterization of Polyhydroxyalkanoate Organo/Hydrogels.

Biomacromolecules 2019 Sep 24;20(9):3303-3312. Epub 2019 May 24.

Center of Synthetic and Systems Biology, School of Life Sciences , Tsinghua-Peking Center for Life Sciences, Tsinghua University , Beijing 100084 , China.

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http://dx.doi.org/10.1021/acs.biomac.9b00479DOI Listing
September 2019

Polyhydroxyalkanoates and Other Biopolymers.

Biomacromolecules 2019 Sep;20(9):3211-3212

Department of Fiber and Polymer Technology , KTH Royal Institute of Technology , SE-100 44 Stockholm , Sweden.

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http://dx.doi.org/10.1021/acs.biomac.9b01044DOI Listing
September 2019

SUMO-Specific Protease 1 Is Critical for Myeloid-Derived Suppressor Cell Development and Function.

Cancer Res 2019 Aug 11;79(15):3891-3902. Epub 2019 Jun 11.

Department of Biochemistry and Molecular Cell Biology, Shanghai Key Laboratory for Tumor Microenvironment and Inflammation, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

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http://dx.doi.org/10.1158/0008-5472.CAN-18-3497DOI Listing
August 2019

Chromosome engineering of the TCA cycle in Halomonas bluephagenesis for production of copolymers of 3-hydroxybutyrate and 3-hydroxyvalerate (PHBV).

Metab Eng 2019 Jul 23;54:69-82. Epub 2019 Mar 23.

MOE Key Lab for Bioinformatics, School of Life Sciences, Tsinghua University, Beijing 100084, China; Tsinghua-Peking Center for Life Sciences, Tsinghua University, Beijing 100084, China; Center for Synthetic and Systems Biology, Tsinghua University, Beijing 100084, China; MOE Key Lab for Industrial Biocatalysis, Dept Chemical Engineering, Tsinghua University, Beijing 100084, China; Center for Nano- and Micro-Mechanics, Tsinghua University, Beijing 100084, China. Electronic address:

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http://dx.doi.org/10.1016/j.ymben.2019.03.006DOI Listing
July 2019

Manipulation of polyhydroxyalkanoate granular sizes in Halomonas bluephagenesis.

Metab Eng 2019 Jul 6;54:117-126. Epub 2019 Apr 6.

MOE Key Lab of Bioinformatics, School of Life Science, Tsinghua-Peking Center for Life Sciences, Tsinghua University, Beijing, 100084, China; Center for Synthetic and Systems Biology, Tsinghua University, Beijing, 100084, China; MOE Key Lab of Industrial Biocatalysis, Dept of Chemical Engineering, Tsinghua University, Beijing, 100084, China. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S10967176193009
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http://dx.doi.org/10.1016/j.ymben.2019.03.011DOI Listing
July 2019

Dihydrogen Splitting by Intramolecular Borane-Phosphane Frustrated Lewis Pairs: A Comprehensive Characterization Strategy Using Solid State NMR and DFT Calculations.

Chemphyschem 2019 07 21;20(14):1837-1849. Epub 2019 Jun 21.

Institut für Physikalische Chemie, WWU Münster, Corrensstraße 30, D-41849, Münster, Germany.

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http://dx.doi.org/10.1002/cphc.201900406DOI Listing
July 2019

Engineering biosynthesis of polyhydroxyalkanoates (PHA) for diversity and cost reduction.

Metab Eng 2019 Jul 11. Epub 2019 Jul 11.

Tsinghua-Peking Center for Life Sciences, Tsinghua University, Beijing, 100084, China; School of Life Sciences, Tsinghua University, Beijing, 100084, China; Center for Synthetic and Systems Biology, Tsinghua University, Beijing, 100084, China; Center for Nano- and Micro-Mechanics, Tsinghua University, Beijing, 100084, China; Dept of Chemical Engineering, Tsinghua University, Beijing, 100084, China. Electronic address:

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http://dx.doi.org/10.1016/j.ymben.2019.07.004DOI Listing
July 2019

Suspended polyhydroxyalkanoate microspheres as 3D carriers for mammalian cell growth.

Artif Cells Nanomed Biotechnol 2018 13;46(sup2):473-483. Epub 2018 Apr 13.

a MOE Key Lab of Bioinformatics , School of Life Sciences, Tsinghua-Peking Center for Life Sciences, Tsinghua University , Beijing , China.

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http://dx.doi.org/10.1080/21691401.2018.1459635DOI Listing
June 2019

Halomonas and Pathway Engineering for Bioplastics Production.

Methods Enzymol 2018 7;608:309-328. Epub 2018 May 7.

MOE Lab of Bioinformatics, School of Life Sciences, Tsinghua University, Beijing, China; Center for Synthetic and Systems Biology, Tsinghua University, Beijing, China; Tsinghua-Peking Center for Life Sciences, Tsinghua University, Beijing, China; Manchester Institute of Biotechnology, Centre for Synthetic Biology, The University of Manchester, Manchester, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/bs.mie.2018.04.008DOI Listing
June 2019

Microbial Poly-3-Hydroxybutyrate (PHB) as a Feed Additive for Fishes and Piglets.

Biotechnol J 2019 May 23:e1900132. Epub 2019 May 23.

School of Life Sciences, Tsinghua-Peking Center for Life Sciences, Center for Synthetic and Systems Biology, Tsinghua University, Beijing, 100084, China.

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https://onlinelibrary.wiley.com/doi/abs/10.1002/biot.2019001
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http://dx.doi.org/10.1002/biot.201900132DOI Listing
May 2019

Engineering self-flocculating Halomonas campaniensis for wastewaterless open and continuous fermentation.

Biotechnol Bioeng 2019 Apr 8;116(4):805-815. Epub 2019 Feb 8.

Center for Synthetic and Systems Biology, School of Life Sciences, Tsinghua University, Beijing, China.

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http://dx.doi.org/10.1002/bit.26897DOI Listing
April 2019

Metabolic Imaging Reveals a Unique Preference of Symmetric Cell Division and Homing of Leukemia-Initiating Cells in an Endosteal Niche.

Cell Metab 2019 Apr 20;29(4):950-965.e6. Epub 2018 Dec 20.

Department of Pathophysiology, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine, 280 South Chongqing Road, Shanghai 200025, China; Shanghai Key Laboratory of Reproductive Medicine, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2018.11.013DOI Listing
April 2019

Engineering Pseudomonas entomophila for synthesis of copolymers with defined fractions of 3-hydroxybutyrate and medium-chain-length 3-hydroxyalkanoates.

Metab Eng 2019 03 21;52:253-262. Epub 2018 Dec 21.

Tsinghua-Peking Center for Life Sciences, Tsinghua University, Beijing 100084, China; School of Life Sciences, Tsinghua University, Beijing 100084, China; Center for Synthetic and Systems Biology, Tsinghua University, Beijing 100084, China; Center for Nano- and Micro-Mechanics, Tsinghua University, Beijing 100084, China. Electronic address:

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http://dx.doi.org/10.1016/j.ymben.2018.12.007DOI Listing
March 2019

Superhydrophobic Polyhydroxyalkanoates: Preparation and Applications.

Biomacromolecules 2019 Feb 18;20(2):618-624. Epub 2018 Sep 18.

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http://dx.doi.org/10.1021/acs.biomac.8b01176DOI Listing
February 2019

Synthesis and Characterization of Electroconductive PHA- graft-Graphene Nanocomposites.

Biomacromolecules 2019 Feb 1;20(2):645-652. Epub 2018 Oct 1.

Center for Synthetic and Systems Biology, School of Life Science , Tsinghua University , Beijing 100084 , China.

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http://dx.doi.org/10.1021/acs.biomac.8b01257DOI Listing
February 2019

Are We There Yet? How and When Specific Biotechnologies Will Improve Human Health.

Biotechnol J 2019 Jan 13;14(1):e1800195. Epub 2018 Jun 13.

Global Future Council on the Future of Biotechnologies, World Economic Forum, Cologny, CH-1223, Geneva, Switzerland.

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http://dx.doi.org/10.1002/biot.201800195DOI Listing
January 2019

2-Bromopalmitate targets retinoic acid receptor alpha and overcomes all-trans retinoic acid resistance of acute promyelocytic leukemia.

Haematologica 2019 Jan 3;104(1):102-112. Epub 2018 Aug 3.

Department of Pathophysiology, Key Laboratory of Cell Differentiation and Apoptosis of the Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine (SJTU-SM)

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http://dx.doi.org/10.3324/haematol.2018.191916DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6312026PMC
January 2019

Vacuolar Protein Sorting 33B Is a Tumor Suppressor in Hepatocarcinogenesis.

Hepatology 2018 12 5;68(6):2239-2253. Epub 2018 Nov 5.

Department of Biochemistry and Molecular Cell Biology, Key Laboratory of Cell Differentiation and Apoptosis of the Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

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http://dx.doi.org/10.1002/hep.30077DOI Listing
December 2018

Biosynthesis of Natural Rubber: Current State and Perspectives.

Int J Mol Sci 2018 Dec 22;20(1). Epub 2018 Dec 22.

CAS Key Laboratory of Biobased Materials, Qingdao Institute of Bioenergy and Bioprocess Technology, Chinese Academy of Sciences, No.189 Songling Road, Laoshan District, Qingdao 266101, China.

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http://dx.doi.org/10.3390/ijms20010050DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337083PMC
December 2018

[Preface for special column on iGEM (2018)].

Sheng Wu Gong Cheng Xue Bao 2018 Dec;34(12):1871-1873

School of Life Sciences, Tsinghua University, Beijing 100084, China.

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http://dx.doi.org/10.13345/j.cjb.180521DOI Listing
December 2018

Engineering microorganisms for improving polyhydroxyalkanoate biosynthesis.

Curr Opin Biotechnol 2018 10 21;53:20-25. Epub 2017 Nov 21.

MOE Lab of Bioinformatics, School of Life Sciences, Tsinghua University, Beijing 100084, China; Center for Synthetic and Systems Biology, Tsinghua University, Beijing 100084, China; Tsinghua-Peking Center for Life Sciences, Tsinghua University, Beijing 100084, China.

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http://dx.doi.org/10.1016/j.copbio.2017.10.008DOI Listing
October 2018

A Multiplex Genome Editing Method for Based on CRISPR-Cas12a.

Front Microbiol 2018 9;9:2307. Epub 2018 Oct 9.

State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, China.

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https://www.frontiersin.org/article/10.3389/fmicb.2018.02307
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http://dx.doi.org/10.3389/fmicb.2018.02307DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6189296PMC
October 2018

[Application perspectives of polyhydroxyalkanoates].

Sheng Wu Gong Cheng Xue Bao 2018 Oct;34(10):1531-1542

School of Life Sciences, Tsinghua University, Beijing 100084, China.

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http://doi.cnki.net/Resolution/Handler?doi=10.13345/j.cjb.18
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http://dx.doi.org/10.13345/j.cjb.180329DOI Listing
October 2018

Efficient Genome Engineering of a Virulent Klebsiella Bacteriophage Using CRISPR-Cas9.

J Virol 2018 09 16;92(17). Epub 2018 Aug 16.

School of Life Science and Biotechnology, Dalian University of Technology, Dalian, People's Republic of China

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http://dx.doi.org/10.1128/JVI.00534-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6096830PMC
September 2018

Engineering NADH/NAD ratio in Halomonas bluephagenesis for enhanced production of polyhydroxyalkanoates (PHA).

Metab Eng 2018 09 13;49:275-286. Epub 2018 Sep 13.

Center for Synthetic and Systems Biology, School of Life Sciences, Tsinghua University, Beijing 100084, China; Tsinghua-Peking Center for Life Sciences, School of Life Sciences, Tsinghua University, Beijing 100084, China; MOE Key Lab of Bioinformatics, Center for Nano and Micro Mechanics, Tsinghua University, Beijing 100084, China; MOE Key Lab of Industrial Biocatalysis, Tsinghua University, Beijing 100084, China. Electronic address:

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http://dx.doi.org/10.1016/j.ymben.2018.09.007DOI Listing
September 2018

A Micro-Ark for Cells: Highly Open Porous Polyhydroxyalkanoate Microspheres as Injectable Scaffolds for Tissue Regeneration.

Adv Mater 2018 Aug 19;30(31):e1802273. Epub 2018 Jun 19.

MOE Key Lab of Bioinformatics, School of Life Sciences, Tsinghua-Peking Center for Life Sciences, Tsinghua University, Beijing, 100084, China.

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http://dx.doi.org/10.1002/adma.201802273DOI Listing
August 2018

Promoter Engineering for Enhanced P(3HB- co-4HB) Production by Halomonas bluephagenesis.

ACS Synth Biol 2018 08 31;7(8):1897-1906. Epub 2018 Jul 31.

MOE Key Lab of Bioinformatics, School of Life Science, Tsinghua-Peking Center for Life Sciences , Tsinghua University , Beijing 100084 , China.

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http://dx.doi.org/10.1021/acssynbio.8b00102DOI Listing
August 2018

Reprogramming Halomonas for industrial production of chemicals.

J Ind Microbiol Biotechnol 2018 Jul 8;45(7):545-554. Epub 2018 Jun 8.

MOE Lab of Bioinformatics, School of Life Sciences, Tsinghua University, 100084, Beijing, China.

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http://link.springer.com/10.1007/s10295-018-2055-z
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http://dx.doi.org/10.1007/s10295-018-2055-zDOI Listing
July 2018

MiR-133b targets Sox9 to control pathogenesis and metastasis of breast cancer.

Cell Death Dis 2018 Jul 3;9(7):752. Epub 2018 Jul 3.

Department of Pathophysiology, Key Laboratory of Cell Differentiation and Apoptosis of National Ministry of Education, Shanghai Jiao Tong University School of Medicine (SJTU-SM), 200025, Shanghai, China.

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http://dx.doi.org/10.1038/s41419-018-0715-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6030174PMC
July 2018

SUMOylation of the m6A-RNA methyltransferase METTL3 modulates its function.

Nucleic Acids Res 2018 06;46(10):5195-5208

Department of Biochemistry and Molecular Cell Biology, Shanghai Key Laboratory of Tumor Microenvironment and Inflammation, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.

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http://dx.doi.org/10.1093/nar/gky156DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6007514PMC
June 2018

Nuclear PTEN safeguards pre-mRNA splicing to link Golgi apparatus for its tumor suppressive role.

Nat Commun 2018 06 19;9(1):2392. Epub 2018 Jun 19.

Department of Pathophysiology, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine (SJTU-SM), Shanghai, 200025, China.

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http://dx.doi.org/10.1038/s41467-018-04760-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6008332PMC
June 2018

Mitotic Phosphorylation of SENP3 Regulates DeSUMOylation of Chromosome-Associated Proteins and Chromosome Stability.

Cancer Res 2018 05 8;78(9):2171-2178. Epub 2018 Feb 8.

Department of Biochemistry and Molecular Cell Biology, Shanghai Key Laboratory for Tumor Microenvironment and Inflammation, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

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http://cancerres.aacrjournals.org/lookup/doi/10.1158/0008-54
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http://dx.doi.org/10.1158/0008-5472.CAN-17-2288DOI Listing
May 2018

Polyhydroxyalkanoates (PHA) for therapeutic applications.

Mater Sci Eng C Mater Biol Appl 2018 May 5;86:144-150. Epub 2018 Jan 5.

MOE Key Lab of Bioinformatics, School of Life Sciences, Tsinghua University, Beijing 100084, China. Electronic address:

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http://dx.doi.org/10.1016/j.msec.2017.12.035DOI Listing
May 2018

Engineering of Halomonas bluephagenesis for low cost production of poly(3-hydroxybutyrate-co-4-hydroxybutyrate) from glucose.

Metab Eng 2018 05 15;47:143-152. Epub 2018 Mar 15.

MOE Key Lab of Bioinformatics, School of Life Sciences, Tsinghua University, Beijing 100084, China; Center for Synthetic and Systems Biology, Tsinghua University, Beijing 100084, China; Center for Nano and Micro-Mechanics, Tsinghua University, Beijing 100084, China. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S10967176183001
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http://dx.doi.org/10.1016/j.ymben.2018.03.013DOI Listing
May 2018

Pilot Scale-up of Poly(3-hydroxybutyrate-co-4-hydroxybutyrate) Production by Halomonas bluephagenesis via Cell Growth Adapted Optimization Process.

Biotechnol J 2018 May 2;13(5):e1800074. Epub 2018 May 2.

MOE Key Lab of Bioinformatics, School of Life Sciences, Tsinghua University, Tsinghua-Peking Center for Life Sciences, Beijing 100084, China.

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http://dx.doi.org/10.1002/biot.201800074DOI Listing
May 2018

JAM3 maintains leukemia-initiating cell self-renewal through LRP5/AKT/β-catenin/CCND1 signaling.

J Clin Invest 2018 05 26;128(5):1737-1751. Epub 2018 Mar 26.

Department of Pathophysiology, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Hongqiao International Institute of Medicine, Shanghai Tongren Hospital/Faculty of Basic Medicine, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

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http://dx.doi.org/10.1172/JCI93198DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5919829PMC
May 2018

Construction of Halomonas bluephagenesis capable of high cell density growth for efficient PHA production.

Appl Microbiol Biotechnol 2018 May 5;102(10):4499-4510. Epub 2018 Apr 5.

MOE Key Lab of Bioinformatics, Department of Biological Science and Biotechnology, School of Life Science, Tsinghua-Peking Center for Life Sciences, Tsinghua University, Beijing, 100084, China.

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http://dx.doi.org/10.1007/s00253-018-8931-7DOI Listing
May 2018

Construction of Halomonas bluephagenesis capable of high cell density growth for efficient PHA production.

Appl Microbiol Biotechnol 2018 May 5;102(10):4499-4510. Epub 2018 Apr 5.

MOE Key Lab of Bioinformatics, Department of Biological Science and Biotechnology, School of Life Science, Tsinghua-Peking Center for Life Sciences, Tsinghua University, Beijing, 100084, China.

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http://dx.doi.org/10.1007/s00253-018-8931-7DOI Listing
May 2018

PPM1K Regulates Hematopoiesis and Leukemogenesis through CDC20-Mediated Ubiquitination of MEIS1 and p21.

Cell Rep 2018 05;23(5):1461-1475

Department of Pathophysiology, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Hongqiao International Institute of Medicine, Shanghai Tongren Hospital/Faculty of Basic Medicine, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2018.03.140DOI Listing
May 2018

Leukaemic alterations of IKZF1 prime stemness and malignancy programs in human lymphocytes.

Cell Death Dis 2018 05 1;9(5):526. Epub 2018 May 1.

Key Laboratory of Cell Differentiation and Apoptosis of Ministry of Education, Department of Pathophysiology and Ruijin Hospital, Shanghai Jiao Tong University School of Medicine (SJTU-SM), Shanghai, 200025, China.

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http://dx.doi.org/10.1038/s41419-018-0600-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5943605PMC
May 2018

Synthetic Biology of Polyhydroxyalkanoates (PHA).

Adv Biochem Eng Biotechnol 2018;162:147-174

MOE Key Lab of Bioinformatics, School of Life Science, Tsinghua-Peking Center for Life Sciences, Tsinghua University, Beijing, 100084, China.

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http://dx.doi.org/10.1007/10_2017_3DOI Listing
April 2018

Next generation industrial biotechnology based on extremophilic bacteria.

Curr Opin Biotechnol 2018 04 7;50:94-100. Epub 2017 Dec 7.

MOE Key Lab on Bioinformatics, School of Life Sciences, Tsinghua University, Beijing 100084, China; Center for Nano and Micro-Mechanics, Tsinghua University, Beijing 100084, China; Tsinghua-Peking Center for Life Sciences, Tsinghua University, Beijing 100084, China.

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http://dx.doi.org/10.1016/j.copbio.2017.11.016DOI Listing
April 2018

Tenogenic Differentiation of Human Embryonic Stem Cells.

Tissue Eng Part A 2018 03 7;24(5-6):361-368. Epub 2017 Jul 7.

1 Guy Hilton Research Centre, Institute for Science and Technology in Medicine, Faculty of Medicine and Health Sciences, Keele University , Thornburrow Drive, Stoke-on-Trent, Staffordshire, United Kingdom .

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http://dx.doi.org/10.1089/ten.TEA.2017.0017DOI Listing
March 2018

Three-Dimensional Printed Skull Base Simulation for Transnasal Endoscopic Surgical Training.

World Neurosurg 2018 Mar 5;111:e773-e782. Epub 2018 Jan 5.

Beijing Neurosurgical Institute, Beijing Tiantan Hospital, Beijing Institute for Brain Disorders Brain Tumor Center, China National Clinical Research Center for Neurological Diseases, Key Laboratory of Central Nervous System Injury Research, Capital Medical University, Beijing, China. Electronic address:

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http://dx.doi.org/10.1016/j.wneu.2017.12.169DOI Listing
March 2018

Microbial polyhydroxyalkanoates as medical implant biomaterials.

Artif Cells Nanomed Biotechnol 2018 Feb 29;46(1):1-18. Epub 2017 Aug 29.

f Laboratory of Fear and Anxiety Disorders , Institute of Life Science, Nanchang University , Nanchang , China.

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http://dx.doi.org/10.1080/21691401.2017.1371185DOI Listing
February 2018

Engineering peptidoglycan degradation related genes of Bacillus subtilis for better fermentation processes.

Bioresour Technol 2018 Jan 23;248(Pt A):238-247. Epub 2017 Jun 23.

Peking-Tsinghua Center for Life Sciences, School of Life Science, Tsinghua University, Beijing 100084, China; Center for Synthetic and Systems Biology, Tsinghua University, Beijing 100084, China; MOE Key Lab of Industrial Biocatalysis, Tsinghua University, Beijing 100081, China. Electronic address:

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http://dx.doi.org/10.1016/j.biortech.2017.05.134DOI Listing
January 2018

Paenibacillus shunpengii sp. nov., isolated from farmland soil.

Int J Syst Evol Microbiol 2018 Jan 14;68(1):211-216. Epub 2017 Nov 14.

3​Laboratory Centre of Life Science, College of Life Science, Nanjing Agricultural University, Nanjing, Jiangsu 210095, PR China.

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http://dx.doi.org/10.1099/ijsem.0.002484DOI Listing
January 2018

Increasing oxygen availability for improving poly(3-hydroxybutyrate) production by Halomonas.

Metab Eng 2018 01 16;45:20-31. Epub 2017 Nov 16.

MOE Key Lab of Bioinformatics, School of Life Sciences, Tsinghua-Peking Center for Life Sciences, Tsinghua University, Beijing 100084, China; Center for Synthetic and Systems Biologsy, Tsinghua University, Beijing 100084, China; Center for Nano and Micro Mechanics, Tsinghua University, Beijing 100084, China; MOE Key Laboratory for Industrial Biocatalysis, Tsinghua University, Beijing 100084, China. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S10967176173035
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http://dx.doi.org/10.1016/j.ymben.2017.11.006DOI Listing
January 2018

Engineering cell wall synthesis mechanism for enhanced PHB accumulation in E. coli.

Metab Eng 2018 01 24;45:32-42. Epub 2017 Nov 24.

MOE Lab for Bioinformatics, Center for Synthetic and Systems Biology, School of Life Sciences, Tsinghua-Peking Center for Life Sciences, Tsinghua University, Beijing 100084, China; Center for Nano and Micro Mechanics, Tsinghua University, Beijing 100084, China; MOE Key Lab for Industrial Biocatalysis, Tsinghua University, Beijing 100084, China; Manchester Institute of Biotechnology, University of Manchester, 131 Princess Street, Manchester M1 7DN, UK. Electronic address:

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http://dx.doi.org/10.1016/j.ymben.2017.11.010DOI Listing
January 2018

MicroRNA-630 inhibits breast cancer progression by directly targeting BMI1.

Exp Cell Res 2018 01 5;362(2):378-385. Epub 2017 Dec 5.

Department of Pathophysiology, Key Laboratory of Cell Differentiation and Apoptosis of National Ministry of Education, Shanghai Jiao-Tong University School of Medicine (SJTU-SM), Shanghai 200025, China. Electronic address:

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http://dx.doi.org/10.1016/j.yexcr.2017.11.039DOI Listing
January 2018

Morphology engineering of bacteria for bio-production.

Biotechnol Adv 2016 Jul-Aug;34(4):435-440. Epub 2015 Dec 19.

MOE Key Lab of Bioinformatics, School of Life Sciences, Tsinghua-Peking Center for Life Sciences, Tsinghua University, Beijing 100084, China; Center for Nano and Micro Mechanics, Tsinghua University, Beijing 100084, China; Beijing Key Laboratory of Protein Therapeutics, Tsinghua University, Beijing 100084, China; Center for Synthetic and Systems Biology, Tsinghua University, Beijing 100084, China. Electronic address:

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http://dx.doi.org/10.1016/j.biotechadv.2015.12.007DOI Listing
December 2017

Pyruvate kinase M2 phosphorylates H2AX and promotes genomic instability in human tumor cells.

Oncotarget 2017 Dec 17;8(65):109120-109134. Epub 2017 Nov 17.

Department of Pathophysiology, Key Laboratory of Cell Differentiation and Apoptosis of Ministry of Education, Shanghai Jiao Tong University School of Medicine (SJTU-SM), Shanghai 200025, China.

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http://dx.doi.org/10.18632/oncotarget.22621DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5752508PMC
December 2017

Engineering Halomonas bluephagenesis TD01 for non-sterile production of poly(3-hydroxybutyrate-co-4-hydroxybutyrate).

Bioresour Technol 2017 Nov 27;244(Pt 1):534-541. Epub 2017 Jul 27.

School of Life Sciences, Tsinghua University, Beijing 100084, China; Center for Nano and Micro-Mechanics, Tsinghua University, Beijing 100084, China; Tsinghua-Peking Center for Life Sciences, Tsinghua University, Beijing 100084, China. Electronic address:

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http://dx.doi.org/10.1016/j.biortech.2017.07.149DOI Listing
November 2017

Modelling of microbial polyhydroxyalkanoate surface binding protein PhaP for rational mutagenesis.

Microb Biotechnol 2017 11 25;10(6):1400-1411. Epub 2017 Aug 25.

Center for Synthetic and Systems Biology, School of Life Sciences, Tsinghua-Peking Center for Life Sciences, Tsinghua University, Beijing, China.

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http://dx.doi.org/10.1111/1751-7915.12820DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5658623PMC
November 2017

Controlling cell volume for efficient PHB production by Halomonas.

Metab Eng 2017 11 14;44:30-37. Epub 2017 Sep 14.

MOE Key Lab of Bioinformatics, School of Life Sciences, Tsinghua-Peking Center for Life Sciences, Tsinghua University, Beijing 100084, China; Center for Synthetic and Systems Biology, Tsinghua University, Beijing 100084, China; Center for Nano and Micro Mechanics, Tsinghua University, Beijing 100084, China; MOE Key Laboratory for Industrial Biocatalysis, Tsinghua University, Beijing 100084, China. Electronic address:

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http://dx.doi.org/10.1016/j.ymben.2017.09.004DOI Listing
November 2017

Co-production of microbial polyhydroxyalkanoates with other chemicals.

Metab Eng 2017 09 3;43(Pt A):29-36. Epub 2017 Aug 3.

Center of Synthetic and Systems Biology, School of Life Science, Tsinghua-Peking Center for Life Sciences, Tsinghua University, Beijing 100084, China; Center for Nano and Micro Mechanics, Tsinghua University, Beijing 100084, China; MOE Key Lab for Industrial Biocatalysis, Tsinghua University, Beijing 100084, China; Manchester Institute of Biotechnology, University of Manchester, Oxford Road, Manchester M13 9PT, UK. Electronic address:

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http://dx.doi.org/10.1016/j.ymben.2017.07.007DOI Listing
September 2017

APC/C is essential for hematopoiesis and impaired in aplastic anemia.

Oncotarget 2017 Sep 28;8(38):63360-63369. Epub 2017 Jun 28.

Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Department of Pathophysiology, Shanghai Jiao Tong University School of Medicine (SJTU-SM), Shanghai, 200025, China.

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http://dx.doi.org/10.18632/oncotarget.18808DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5609928PMC
September 2017

Engineering bacteria for enhanced polyhydroxyalkanoates (PHA) biosynthesis.

Synth Syst Biotechnol 2017 Sep 22;2(3):192-197. Epub 2017 Sep 22.

School of Life Sciences, Tsinghua University, Beijing 100084, China.

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http://dx.doi.org/10.1016/j.synbio.2017.09.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5655382PMC
September 2017

Controlling microbial PHB synthesis via CRISPRi.

Appl Microbiol Biotechnol 2017 Jul 15;101(14):5861-5867. Epub 2017 Jun 15.

Center for Synthetic and Systems Biology, School of Life Science, Tsinghua-Peking Center for Life Sciences, Tsinghua University, Beijing, 100084, China.

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http://link.springer.com/10.1007/s00253-017-8374-6
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http://dx.doi.org/10.1007/s00253-017-8374-6DOI Listing
July 2017

DNMT1-maintained hypermethylation of Krüppel-like factor 5 involves in the progression of clear cell renal cell carcinoma.

Cell Death Dis 2017 07 27;8(7):e2952. Epub 2017 Jul 27.

Department of Pathophysiology, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine (SJTU-SM), Shanghai, China.

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http://dx.doi.org/10.1038/cddis.2017.323DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5550868PMC
July 2017

Correction: Nitro-redox reactions at a frustrated borane/phosphane Lewis pair.

Dalton Trans 2017 06;46(22):7369

Organisch-Chemisches Institut der Universität Münster, Corrensstraβe 40, 48149 Münster, Germany.

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http://dx.doi.org/10.1039/c7dt90093gDOI Listing
June 2017

VHL deficiency augments anthracycline sensitivity of clear cell renal cell carcinomas by down-regulating ALDH2.

Nat Commun 2017 06 15;8:15337. Epub 2017 Jun 15.

Institute of Fudan-Minhang Academic Health System, Minhang Hospital, Fudan University, 170 Xinsong Road, Shanghai 201199, China.

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http://dx.doi.org/10.1038/ncomms15337DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5481740PMC
June 2017

Inhibition of Snail Family Transcriptional Repressor 2 (SNAI2) Enhances Multidrug Resistance of Hepatocellular Carcinoma Cells.

PLoS One 2016 19;11(10):e0164752. Epub 2016 Oct 19.

Key Laboratory of Cell Differentiation and Apoptosis of Ministry of Education of China, Department of Pathophysiology, Shanghai Jiao Tong University School of Medicine (SJTU-SM), Shanghai, China.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0164752PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5070735PMC
May 2017

CD244 maintains the proliferation ability of leukemia initiating cells through SHP-2/p27 signaling.

Haematologica 2017 04 25;102(4):707-718. Epub 2017 Jan 25.

Hongqiao International Institute of Medicine, Shanghai Tongren Hospital, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Faculty of Basic Medicine, Shanghai Jiao Tong University School of Medicine, China

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http://dx.doi.org/10.3324/haematol.2016.151555DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5395111PMC
April 2017

Synthesis of Medium-Chain-Length Polyhydroxyalkanoate Homopolymers, Random Copolymers, and Block Copolymers by an Engineered Strain of Pseudomonas entomophila.

Adv Healthc Mater 2017 Apr 27;6(7). Epub 2017 Jan 27.

School of Life Science, Tsinghua University, Beijing, 100084, China.

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http://dx.doi.org/10.1002/adhm.201601017DOI Listing
April 2017

Intermolecular Redox-Neutral Amine C-H Functionalization Induced by the Strong Boron Lewis Acid B(C F ) in the Frustrated Lewis Pair Regime.

Chemistry 2017 Apr 15;23(19):4723-4729. Epub 2017 Mar 15.

Organisch-Chemisches Institut der, Universität Münster, Corrensstraße 40, 48149, Münster, Germany.

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http://doi.wiley.com/10.1002/chem.201700477
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http://dx.doi.org/10.1002/chem.201700477DOI Listing
April 2017

Study of the tensile properties of individual multicellular fibres generated by Bacillus subtilis.

Sci Rep 2017 04 5;7:46052. Epub 2017 Apr 5.

Center for Nano and Micro Mechanics, Tsinghua University, Beijing 100084, China.

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http://dx.doi.org/10.1038/srep46052DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5380956PMC
April 2017

Engineering Halomonas species TD01 for enhanced polyhydroxyalkanoates synthesis via CRISPRi.

Microb Cell Fact 2017 Apr 6;16(1):48. Epub 2017 Apr 6.

School of Life Sciences, Tsinghua University, Beijing, 100084, China.

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http://dx.doi.org/10.1186/s12934-017-0655-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5382479PMC
April 2017

Microbial synthesis of a novel terpolyester P(LA-co-3HB-co-3HP) from low-cost substrates.

Microb Biotechnol 2017 03 17;10(2):371-380. Epub 2016 Nov 17.

Center for Synthetic and Systems Biology, School of Life Science, Tsinghua-Peking Center for Life Sciences, Tsinghua University, Beijing, 100084, China.

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http://dx.doi.org/10.1111/1751-7915.12453DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5328817PMC
March 2017

Novel T7-like expression systems used for Halomonas.

Metab Eng 2017 01 24;39:128-140. Epub 2016 Nov 24.

Center for Synthetic and Systems Biology, School of Life Sciences, Tsinghua-Peking Center for Life Sciences, Tsinghua University, Beijing 100084, China. Electronic address:

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http://dx.doi.org/10.1016/j.ymben.2016.11.007DOI Listing
January 2017

Unveiling the 30-year mystery of polyhydroxyalkanoate (PHA) synthase.

Biotechnol J 2017 01 30;12(1). Epub 2016 Nov 30.

School of Life Sciences, Tsinghua University, Beijing, China.

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http://dx.doi.org/10.1002/biot.201600659DOI Listing
January 2017

MicroRNA-494 inhibits breast cancer progression by directly targeting PAK1.

Cell Death Dis 2017 01 5;8(1):e2529. Epub 2017 Jan 5.

Key Laboratory of Cell Differentiation and Apoptosis of National Ministry of Education, Department of Pathophysiology and Rui-Jin Hospital, Shanghai Jiao Tong University School of Medicine (SJTU-SM), Shanghai, China.

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http://dx.doi.org/10.1038/cddis.2016.440DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5386359PMC
January 2017

Engineering the growth pattern and cell morphology for enhanced PHB production by Escherichia coli.

Appl Microbiol Biotechnol 2016 Dec 11;100(23):9907-9916. Epub 2016 Jul 11.

Center for Synthetic and Systems Biology, School of Life Science, Tsinghua-Peking Center for Life Sciences, Tsinghua University, Beijing, 100084, China.

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http://dx.doi.org/10.1007/s00253-016-7715-1DOI Listing
December 2016

Engineering Halomonas spp. as A Low-Cost Production Host for Production of Bio-surfactant Protein PhaP.

Biotechnol J 2016 Dec 26;11(12):1595-1604. Epub 2016 Oct 26.

School of Life Sciences, Tsinghua University, Beijing, China.

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http://doi.wiley.com/10.1002/biot.201600459
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http://dx.doi.org/10.1002/biot.201600459DOI Listing
December 2016

A Novel Role for Pyruvate Kinase M2 as a Corepressor for P53 during the DNA Damage Response in Human Tumor Cells.

J Biol Chem 2016 Dec 3;291(50):26138-26150. Epub 2016 Nov 3.

From the Department of Pathophysiology, Key Laboratory of Cell Differentiation and Apoptosis of Ministry of Education, Shanghai Jiao Tong University School of Medicine (SJTU-SM), Shanghai 200025, China and

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http://dx.doi.org/10.1074/jbc.M116.737056DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5207082PMC
December 2016

Lack of association between vitamin D receptor polymorphisms ApaI (rs7975232) and BsmI (rs1544410) and osteoporosis among the Han Chinese population: A meta-analysis.

Kaohsiung J Med Sci 2016 Dec 14;32(12):599-606. Epub 2016 Nov 14.

Department of Orthopedics, Beijing Shijitan Hospital Affiliated to Capital Medical University, Beijing, China.

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http://dx.doi.org/10.1016/j.kjms.2016.10.002DOI Listing
December 2016

Structural Insights on PHA Binding Protein PhaP from Aeromonas hydrophila.

Sci Rep 2016 12 23;6:39424. Epub 2016 Dec 23.

Center for Synthetic and Systems Biology, School of Life Science, Tsinghua-Peking Center for Life Sciences, Tsinghua University, Beijing 100084, China.

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http://dx.doi.org/10.1038/srep39424DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5180188PMC
December 2016

Synthetic biology of microbes synthesizing polyhydroxyalkanoates (PHA).

Synth Syst Biotechnol 2016 Dec 7;1(4):236-242. Epub 2016 Oct 7.

School of Life Sciences, Tsinghua University, Beijing 100084, China.

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http://dx.doi.org/10.1016/j.synbio.2016.09.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5625728PMC
December 2016

Semirational Approach for Ultrahigh Poly(3-hydroxybutyrate) Accumulation in Escherichia coli by Combining One-Step Library Construction and High-Throughput Screening.

ACS Synth Biol 2016 11 10;5(11):1308-1317. Epub 2016 May 10.

MOE Key Lab of Bioinformatics, Department of Biological Science and Biotechnology, School of Life Science, Tsinghua-Peking Center for Life Sciences, Tsinghua University , Beijing 100084, China.

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http://dx.doi.org/10.1021/acssynbio.6b00083DOI Listing
November 2016

Microbial Synthesis of 5-Aminolevulinic Acid and Its Coproduction with Polyhydroxybutyrate.

ACS Synth Biol 2016 11 9;5(11):1264-1274. Epub 2016 Jun 9.

Peking-Tsinghua Center for Life Sciences, School of Life Science, Tsinghua University , Beijing 100084, China.

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http://dx.doi.org/10.1021/acssynbio.6b00105DOI Listing
November 2016

A novel cell autolysis system for cost-competitive downstream processing.

Appl Microbiol Biotechnol 2016 Nov 15;100(21):9103-9110. Epub 2016 Jun 15.

Peking-Tsinghua Center for Life Sciences, School of Life Science, Tsinghua University, Beijing, 100084, China.

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http://dx.doi.org/10.1007/s00253-016-7669-3DOI Listing
November 2016

Downregulation of AIF by HIF-1 contributes to hypoxia-induced epithelial-mesenchymal transition of colon cancer.

Carcinogenesis 2016 11;37(11):1079-1088

Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Department of Pathophysiology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine (SJTU-SM) , Shanghai 200025 , China and.

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http://dx.doi.org/10.1093/carcin/bgw089DOI Listing
November 2016

CRISPRi engineering E. coli for morphology diversification.

Metab Eng 2016 11 28;38:358-369. Epub 2016 Sep 28.

Center of Synthetic and Systems Biology, School of Life Science, Tsinghua-Peking Center for Life Sciences, Tsinghua University, Beijing 100084, China; Center for Nano and Micro Mechanics, Tsinghua University, Beijing 100084, China; MOE Key Lab for Industrial Biocatalysis, Tsinghua University, Beijing 100084, China. Electronic address:

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http://dx.doi.org/10.1016/j.ymben.2016.09.001DOI Listing
November 2016

CD274 promotes cell cycle entry of leukemia-initiating cells through JNK/Cyclin D2 signaling.

J Hematol Oncol 2016 11 17;9(1):124. Epub 2016 Nov 17.

Department of Hematology, Shanghai Tongji Hospital, Shanghai Tongji University School of Medicine, Shanghai, China; Hongqiao International Institute of Medicine,Shanghai Tongren Hospital, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

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http://dx.doi.org/10.1186/s13045-016-0350-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5114730PMC
November 2016

FAM122A, a new endogenous inhibitor of protein phosphatase 2A.

Oncotarget 2016 Sep;7(39):63887-63900

Institute of Health Sciences, Shanghai Institutes for Biological Sciences of Chinese Academy of Sciences and Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.

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http://dx.doi.org/10.18632/oncotarget.11698DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5325411PMC
September 2016

Synthesis, Characterization and Application of Thermoresponsive Polyhydroxyalkanoate-graft-Poly(N-isopropylacrylamide).

Biomacromolecules 2016 08 7;17(8):2680-90. Epub 2016 Jul 7.

Center of Synthetic and Systems Biology, School of Life Science, Tsinghua-Peking Center for Life Sciences, Tsinghua University , Beijing 100084, China.

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http://dx.doi.org/10.1021/acs.biomac.6b00724DOI Listing
August 2016

Molecular Mechanism of Z α1-Antitrypsin Deficiency.

J Biol Chem 2016 07 31;291(30):15674-86. Epub 2016 May 31.

the Hongqiao International Institute of Medicine, Shanghai Tongren Hospital/Faculty of Basic Medicine, Chemical Biology Division of Shanghai Universities E-Institutes, Key Laboratory of Cell Differentiation and Apoptosis of the Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China, and

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http://dx.doi.org/10.1074/jbc.M116.727826DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4957051PMC
July 2016

Phospha-Claisen Type Reactions at Frustrated Lewis Pair Frameworks.

J Am Chem Soc 2016 07 1;138(27):8554-9. Epub 2016 Jul 1.

Organisch-Chemisches, Institut der Universität Münster , Corrensstraβe 40, 48149 Münster, Germany.

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http://dx.doi.org/10.1021/jacs.6b04046DOI Listing
July 2016

Enhanced production of polyhydroxybutyrate by multiple dividing E. coli.

Microb Cell Fact 2016 Jul 27;15(1):128. Epub 2016 Jul 27.

School of Life Sciences, Tsinghua University, Beijing, 100084, China.

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http://dx.doi.org/10.1186/s12934-016-0531-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4964105PMC
July 2016

Omics Meets Metabolic Pathway Engineering.

Authors:
Guo-Qiang Chen

Cell Syst 2016 06 26;2(6):362-3. Epub 2016 May 26.

Peking-Tsinghua Center for Life Sciences, School of Life Science, Tsinghua University, Beijing 100084, China; Center for Synthetic and Systems Biology, Tsinghua University, Beijing 100084, China; MOE Key Lab of Industrial Biocatalysis, Tsinghua University, Beijing 100081, China. Electronic address:

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http://dx.doi.org/10.1016/j.cels.2016.05.005DOI Listing
June 2016

Nitro-redox reactions at a frustrated borane/phosphane Lewis pair.

Dalton Trans 2016 Apr;45(16):6820-3

Organisch-Chemisches Institut der Universität Münster, Corrensstraβe 40, 48149 Münster, Germany.

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http://dx.doi.org/10.1039/c6dt00857gDOI Listing
April 2016

Formation of Thermally Robust Frustrated Lewis Pairs by Electrocyclic Ring Closure Reactions.

Angew Chem Int Ed Engl 2016 04 24;55(18):5526-30. Epub 2016 Mar 24.

Organisch-Chemisches Institut der Universität Münster, Corrensstraße 40, 48149, Münster, Germany.

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http://dx.doi.org/10.1002/anie.201510994DOI Listing
April 2016

MiR-630 suppresses breast cancer progression by targeting metadherin.

Oncotarget 2016 Jan;7(2):1288-99

Department of Pathophysiology, Key Laboratory of Cell Differentiation and Apoptosis of National Ministry of Education, Shanghai Jiao Tong University School of Medicine (SJTU-SM), Shanghai 200025, China.

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http://dx.doi.org/10.18632/oncotarget.6339DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4811460PMC
January 2016