Guo-Chang Fan, PhD - University of Cincinnati College of Medicine - Full Professor

Guo-Chang Fan

PhD

University of Cincinnati College of Medicine

Full Professor

Cincinnati, OH | United States

Main Specialties: Biology, Cardiovascular Disease, Critical Care Medicine, Endocrinology Diabetes & Metabolism, Infectious Disease, Pharmacology

Additional Specialties: Molecular and Cellular Cardiology

ORCID logohttps://orcid.org/0000-0002-0439-8277

Guo-Chang Fan, PhD - University of Cincinnati College of Medicine - Full Professor

Guo-Chang Fan

PhD

Publications

92Publications

2293Reads

221Profile Views

2079PubMed Central Citations

Tumor susceptibility gene 101 ameliorates endotoxin-induced cardiac dysfunction by enhancing Parkin-mediated mitophagy.

J Biol Chem 2019 11 16;294(48):18057-18068. Epub 2019 Oct 16.

Department of Pharmacology and Systems Physiology, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267

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http://dx.doi.org/10.1074/jbc.RA119.008925DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6885607PMC
November 2019
4.573 Impact Factor

Nicotinamide riboside promotes autolysosome clearance in preventing doxorubicin-induced cardiotoxicity.

Clin Sci (Lond) 2019 07 15;133(13):1505-1521. Epub 2019 Jul 15.

Institutes of Biology and Medical Sciences, Soochow University, Suzhou 215123, China

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http://dx.doi.org/10.1042/CS20181022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6705112PMC
July 2019
9 Reads
5.598 Impact Factor

MicroRNA-223 is essential for maintaining functional β-cell mass during diabetes through inhibiting both FOXO1 and SOX6 pathways.

J Biol Chem 2019 07 22;294(27):10438-10448. Epub 2019 May 22.

From the Department of Pharmacology and Systems Physiology, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267,

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http://dx.doi.org/10.1074/jbc.RA119.007755DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6615686PMC
July 2019
1 Read
4.573 Impact Factor

Tsg101 positively regulates physiologic-like cardiac hypertrophy through FIP3-mediated endosomal recycling of IGF-1R.

FASEB J 2019 06 18;33(6):7451-7466. Epub 2019 Mar 18.

Department of Pharmacology and Systems Physiology, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.

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http://dx.doi.org/10.1096/fj.201802338RRDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6529337PMC
June 2019
5 Reads
5.043 Impact Factor

Selective deletion of endothelial cell calpain in mice reduces diabetic cardiomyopathy by improving angiogenesis.

Diabetologia 2019 05 18;62(5):860-872. Epub 2019 Feb 18.

Institutes of Biology and Medical Sciences, Soochow University, Suzhou, China.

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http://dx.doi.org/10.1007/s00125-019-4828-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6702672PMC
May 2019
2 Reads
6.671 Impact Factor

Calpain-2 promotes MKP-1 expression protecting cardiomyocytes in both in vitro and in vivo mouse models of doxorubicin-induced cardiotoxicity.

Arch Toxicol 2019 04 27;93(4):1051-1065. Epub 2019 Feb 27.

Jiangsu Key Laboratory of Infection and Immunity, Institutes of Biology and Medical Sciences, Soochow University, Suzhou, 215123, China.

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http://link.springer.com/10.1007/s00204-019-02405-w
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http://dx.doi.org/10.1007/s00204-019-02405-wDOI Listing
April 2019
26 Reads
5.980 Impact Factor

Phosphorylation of Hsp20 Promotes Fibrotic Remodeling and Heart Failure.

JACC Basic Transl Sci 2019 Apr 29;4(2):188-199. Epub 2019 Apr 29.

Department of Pharmacology and Systems Physiology, University of Cincinnati College of Medicine, Cincinnati, Ohio.

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http://dx.doi.org/10.1016/j.jacbts.2018.11.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6488766PMC
April 2019
3 Reads

Increased calpain-1 in mitochondria induces dilated heart failure in mice: role of mitochondrial superoxide anion.

Basic Res Cardiol 2019 03 15;114(3):17. Epub 2019 Mar 15.

Institutes of Biology and Medical Sciences, Soochow University, Suzhou, 215123, China.

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http://dx.doi.org/10.1007/s00395-019-0726-1DOI Listing
March 2019
4 Reads
5.414 Impact Factor

Regulation of BECN1-mediated autophagy by HSPB6: Insights from a human HSPB6 mutant.

Autophagy 2018 29;14(1):80-97. Epub 2018 Jan 29.

a Department of Pharmacology & System Physiology , University of Cincinnati College of Medicine, Cincinnati , OH , USA.

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http://dx.doi.org/10.1080/15548627.2017.1392420DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5846551PMC
February 2019
14 Reads
1 Citation
11.753 Impact Factor

Administration of nicotinamide riboside prevents oxidative stress and organ injury in sepsis.

Free Radic Biol Med 2018 08 24;123:125-137. Epub 2018 May 24.

Lawson Health Research Institute, London Health Sciences Centre, London, Ontario, Canada N6A 4G5; Department of Pathology and Laboratory Medicine, Western University, London, Ontario, Canada N6A 4G5; Department of Medicine, Western University, London, Ontario, Canada N6A 4G5; Jiangsu Key Laboratory of Infection and Immunity, Institutes of Biology and Medical Sciences, Soochow University, Suzhou 215123, China. Electronic address:

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http://dx.doi.org/10.1016/j.freeradbiomed.2018.05.073DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6236680PMC
August 2018
17 Reads
1 Citation
5.740 Impact Factor

An Hsp20-FBXO4 Axis Regulates Adipocyte Function through Modulating PPARγ Ubiquitination.

Cell Rep 2018 06;23(12):3607-3620

Department of Pharmacology and Systems Physiology, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2018.05.065DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6091893PMC
June 2018
19 Reads
7.210 Impact Factor

Versatile effects of bacterium-released membrane vesicles on mammalian cells and infectious/inflammatory diseases.

Acta Pharmacol Sin 2018 Apr 31;39(4):514-533. Epub 2017 Aug 31.

Department of Pharmacology and Cell Biophysics, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA.

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http://www.nature.com/doifinder/10.1038/aps.2017.82
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http://dx.doi.org/10.1038/aps.2017.82DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5888691PMC
April 2018
212 Reads
2 Citations
2.500 Impact Factor

Extracellular vesicles as novel biomarkers and pharmaceutic targets of diseases.

Acta Pharmacol Sin 2018 Apr;39(4):499-500

Department of Pharmacology, University of Nevada School of Medicine, Reno, NV 89557, USA.

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http://dx.doi.org/10.1038/aps.2018.15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5888692PMC
April 2018
6 Reads
2.500 Impact Factor

Disruption of calpain reduces lipotoxicity-induced cardiac injury by preventing endoplasmic reticulum stress.

Biochim Biophys Acta 2016 Nov 12;1862(11):2023-2033. Epub 2016 Aug 12.

Institutes of Biology and Medical Sciences, Soochow University, Suzhou, Jiangsu Province 215123, China; Critical Illness Research, Lawson Health Research Institute, Western University, London, Ontario N6A 4G5, Canada; Department of Medicine, Western University, London, Ontario N6A 4G5, Canada; Department of Pathology and Laboratory Medicine, Western University, London, Ontario N6A 4G5, Canada. Electronic address:

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5066874PMC
http://dx.doi.org/10.1016/j.bbadis.2016.08.005DOI Listing
November 2016
36 Reads
4 Citations

Hsp20-Mediated Activation of Exosome Biogenesis in Cardiomyocytes Improves Cardiac Function and Angiogenesis in Diabetic Mice.

Diabetes 2016 10 9;65(10):3111-28. Epub 2016 Jun 9.

Department of Pharmacology and Cell Biophysics, University of Cincinnati College of Medicine, Cincinnati, OH

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http://dx.doi.org/10.2337/db15-1563DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5033265PMC
October 2016
9 Reads
23 Citations
8.100 Impact Factor

MicroRNA-223-5p and -3p Cooperatively Suppress Necroptosis in Ischemic/Reperfused Hearts.

J Biol Chem 2016 09 8;291(38):20247-59. Epub 2016 Aug 8.

Department of Pharmacology and Cell Biophysics, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267,

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http://dx.doi.org/10.1074/jbc.M116.732735DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5025706PMC
September 2016
33 Reads
6 Citations
4.573 Impact Factor

Heat stress prevents lipopolysaccharide-induced apoptosis in pulmonary microvascular endothelial cells by blocking calpain/p38 MAPK signalling.

Apoptosis 2016 08;21(8):896-904

Department of Intensive Care Unit, General Hospital of Guangzhou Military Command, Guangzhou, 510010, China.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5069199PMC
http://dx.doi.org/10.1007/s10495-016-1263-0DOI Listing
August 2016
81 Reads
4 Citations
3.685 Impact Factor

Inhibition of cerebral vascular inflammation by brain endothelium-targeted oligodeoxynucleotide complex.

Neuroscience 2016 08 27;329:30-42. Epub 2016 Apr 27.

Division of Pharmaceutical Sciences, James L. Winkle College of Pharmacy, University of Cincinnati, Cincinnati, OH 45267, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neuroscience.2016.04.033DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905813PMC
August 2016
4 Reads
1 Citation
3.360 Impact Factor

MiRNA-Mediated Macrophage Polarization and its Potential Role in the Regulation of Inflammatory Response.

Shock 2016 08;46(2):122-31

Department of Pharmacology and Cell Biophysics, University of Cincinnati College of Medicine, Cincinnati, Ohio.

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http://dx.doi.org/10.1097/SHK.0000000000000604DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4949115PMC
August 2016
17 Reads
23 Citations
3.045 Impact Factor

Inhibition of MicroRNA 195 Prevents Apoptosis and Multiple-Organ Injury in Mouse Models of Sepsis.

J Infect Dis 2016 May 23;213(10):1661-70. Epub 2015 Dec 23.

Jiangsu Key Laboratory of Infection and Immunity, Institutes for Biology and Medical Sciences, Soochow University, Suzhou Lawson Health Research Institute Department of Medicine Department of Pathology, University of Western Ontario, London, Canada.

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http://dx.doi.org/10.1093/infdis/jiv760DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4837905PMC
May 2016
37 Reads
8 Citations
6.000 Impact Factor

Therapeutic inhibition of mitochondrial reactive oxygen species with mito-TEMPO reduces diabetic cardiomyopathy.

Free Radic Biol Med 2016 Jan 11;90:12-23. Epub 2015 Nov 11.

Jiangsu Key Laboratory of Infection and Immunity, Institutes of Biology and Medical Sciences, Soochow University, Suzhou, Jiangsu Province 215123, China; Critical Illness Research, Lawson Health Research Institute, London Health Sciences Centre, VRL 6th Floor, A6-140, 800 Commissioners Road, London, Ont., Canada N6A 4G5; Departments of Medicine and Pathology, The University of Western Ontario, London, Ont., Canada N6A 4G5. Electronic address:

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5066872PMC
http://dx.doi.org/10.1016/j.freeradbiomed.2015.11.013DOI Listing
January 2016
75 Reads
17 Citations
5.740 Impact Factor

Mitochondrial Calpain-1 Disrupts ATP Synthase and Induces Superoxide Generation in Type 1 Diabetic Hearts: A Novel Mechanism Contributing to Diabetic Cardiomyopathy.

Diabetes 2016 Jan 15;65(1):255-68. Epub 2015 Oct 15.

Institutes of Biology and Medical Sciences, Soochow University, Suzhou, Jiangsu Province, China Department of Medicine, Lawson Health Research Institute, University of Western Ontario, London, Ontario, Canada Department of Pathology, Lawson Health Research Institute, University of Western Ontario, London, Ontario, Canada

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http://dx.doi.org/10.2337/db15-0963DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4686953PMC
January 2016
50 Reads
14 Citations
8.100 Impact Factor

Blockade of exosome generation with GW4869 dampens the sepsis-induced inflammation and cardiac dysfunction.

Biochim Biophys Acta 2015 Nov 20;1852(11):2362-71. Epub 2015 Aug 20.

Department of Pharmacology and Cell Biophysics, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA. Electronic address:

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http://dx.doi.org/10.1016/j.bbadis.2015.08.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4581992PMC
November 2015
21 Reads
33 Citations

IRF8 suppresses pathological cardiac remodelling by inhibiting calcineurin signalling.

Nat Commun 2014 ;5:3303

1] Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan 430060, China [2] Cardiovascular Research Institute of Wuhan University, Wuhan 430060, China.

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http://dx.doi.org/10.1038/ncomms4303DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3929801PMC
November 2015
9 Reads
29 Citations
10.742 Impact Factor

Deletion of capn4 Protects the Heart Against Endotoxemic Injury by Preventing ATP Synthase Disruption and Inhibiting Mitochondrial Superoxide Generation.

Circ Heart Fail 2015 Sep 5;8(5):988-96. Epub 2015 Aug 5.

From the Jiangsu Key Laboratory of Infection and Immunity, Institutes of Biology and Medical Sciences, Soochow University, Suzhou, Jiangsu, China (R.N., D.Z., T.P.); Lawson Health Research Institute, Departments of Medicine (R.N., D.Z., T.S., T.P.), Pathology (R.N., D.Z., T.P.) and Biology (R.B.G.), University of Western Ontario, London, Ontario, Canada; Department of Dermatology (Q.W.) and Institute of Cardiovascular Diseases (Y.Y., R.C.), Zhongshan Hospital, Fudan University, Shanghai, China; Mitochondria and Metabolism Center, Departments of Anesthesiology and Pain Medicine, University of Washington, Seattle (W.W.); Department of Pharmacology and Cell Biophysics, University of Cincinnati College of Medicine, OH (G.-C.F.); and Division of Cancer Biology and Genetics, Queen's University Cancer Research Institute, Department of Pathology and Molecular Medicine, Queen's University, Kingston, Ontario, Canada (P.A.G.).

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http://dx.doi.org/10.1161/CIRCHEARTFAILURE.115.002383DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4573911PMC
September 2015
13 Reads
5 Citations
5.891 Impact Factor

Exosomal miR-223 Contributes to Mesenchymal Stem Cell-Elicited Cardioprotection in Polymicrobial Sepsis.

Sci Rep 2015 Sep 8;5:13721. Epub 2015 Sep 8.

Department of Pharmacology and Cell Biophysics, University of Cincinnati College of Medicine, Cincinnati, OH, USA.

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http://dx.doi.org/10.1038/srep13721DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4562230PMC
September 2015
90 Reads
40 Citations
5.080 Impact Factor

Silencing of miR-195 reduces diabetic cardiomyopathy in C57BL/6 mice.

Diabetologia 2015 Aug 21;58(8):1949-58. Epub 2015 May 21.

Institutes of Biology and Medical Sciences, Soochow University, Suzhou, Jiangsu Province, China, 215123.

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http://dx.doi.org/10.1007/s00125-015-3622-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4499474PMC
August 2015
40 Reads
22 Citations
6.671 Impact Factor

MicroRNA-377 regulates mesenchymal stem cell-induced angiogenesis in ischemic hearts by targeting VEGF.

PLoS One 2014 24;9(9):e104666. Epub 2014 Sep 24.

Department of Pathology and Lab Medicine, University of Cincinnati Medical Center, Cincinnati, Ohio, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0104666PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4174502PMC
June 2015
49 Reads
17 Citations
3.234 Impact Factor

Calpain-1 induces endoplasmic reticulum stress in promoting cardiomyocyte apoptosis following hypoxia/reoxygenation.

Biochim Biophys Acta 2015 May 4;1852(5):882-92. Epub 2015 Feb 4.

Institutes of Biology and Medical Science, Soochow University, Suzhou 215123, China; Critical Illness Research, Lawson Health Research Institute, Canada; Department of Medicine, University of Western Ontario, London, Ontario N6A 4G5, Canada; Department of Pathology, University of Western Ontario, London, Ontario N6A 4G5, Canada; Institute of Cardiovascular Science, Soochow University, Suzhou 215008, China. Electronic address:

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http://dx.doi.org/10.1016/j.bbadis.2015.01.019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4418534PMC
May 2015
8 Reads
8 Citations

Pathologic function and therapeutic potential of exosomes in cardiovascular disease.

Biochim Biophys Acta 2015 Jan 16;1852(1):1-11. Epub 2014 Oct 16.

Department of Pharmacology and Cell Biophysics, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA. Electronic address:

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http://dx.doi.org/10.1016/j.bbadis.2014.10.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4268281PMC
January 2015
9 Reads
44 Citations

Hypoxic exosomes promote angiogenesis.

Authors:
Guo-Chang Fan

Blood 2014 Dec;124(25):3669-70

UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE.

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http://dx.doi.org/10.1182/blood-2014-10-607846DOI Listing
December 2014
1 Read
11 Citations
10.452 Impact Factor

Role of extracellular and intracellular microRNAs in sepsis.

Biochim Biophys Acta 2014 Nov 31;1842(11):2155-2162. Epub 2014 Jul 31.

Department of Pharmacology and Cell Biophysics, University of Cincinnati College of Medicine, Cincinnati, OH 45267, United States. Electronic address:

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http://dx.doi.org/10.1016/j.bbadis.2014.07.021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4188718PMC
November 2014
3 Reads
18 Citations

TRAF1 is a critical regulator of cerebral ischaemia-reperfusion injury and neuronal death.

Nat Commun 2013 ;4:2852

1] Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan 430060, China [2] Cardiovascular Research Institute of Wuhan University, Wuhan 430060, China [3].

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http://dx.doi.org/10.1038/ncomms3852DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3868160PMC
October 2014
61 Reads
19 Citations
10.742 Impact Factor

An intragenic SRF-dependent regulatory motif directs cardiac-specific microRNA-1-1/133a-2 expression.

PLoS One 2013 13;8(9):e75470. Epub 2013 Sep 13.

Hainan Provincial Key Laboratory for Human Reproductive Medicine and Genetic Research, Cardiovascular Disease and Research Institute, Affiliated Hospital of Hainan Medical College, Haikou, Hainan, China.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0075470PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3772891PMC
September 2014
10 Reads
3 Citations
3.234 Impact Factor

Cardiomyocytes mediate anti-angiogenesis in type 2 diabetic rats through the exosomal transfer of miR-320 into endothelial cells.

J Mol Cell Cardiol 2014 Sep 10;74:139-50. Epub 2014 May 10.

Department of Pharmacology and Cell Biophysics, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA. Electronic address:

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http://dx.doi.org/10.1016/j.yjmcc.2014.05.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4120246PMC
September 2014
63 Reads
72 Citations
4.660 Impact Factor

Nemo-like kinase (NLK) negatively regulates NF-kappa B activity through disrupting the interaction of TAK1 with IKKβ.

Biochim Biophys Acta 2014 Jul 12;1843(7):1365-72. Epub 2014 Apr 12.

College of Life Sciences, Wuhan University, Wuhan 430072, China. Electronic address:

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http://dx.doi.org/10.1016/j.bbamcr.2014.03.028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4655877PMC
July 2014
35 Reads
7 Citations

Loss of duplexmiR-223 (5p and 3p) aggravates myocardial depression and mortality in polymicrobial sepsis.

Biochim Biophys Acta 2014 May 29;1842(5):701-11. Epub 2014 Jan 29.

Department of Pharmacology and Cell Biophysics. Electronic address:

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http://dx.doi.org/10.1016/j.bbadis.2014.01.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3959587PMC
May 2014
15 Reads
16 Citations

Interferon regulatory factor 7 functions as a novel negative regulator of pathological cardiac hypertrophy.

Hypertension 2014 Apr 6;63(4):713-22. Epub 2014 Jan 6.

Department of Cardiology, Renmin Hospital of Wuhan University, Cardiovascular Research Institute, Wuhan University, Jiefang Road 238, Wuhan 430060, PR China.

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http://dx.doi.org/10.1161/HYPERTENSIONAHA.113.02653DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5349187PMC
April 2014
142 Reads
19 Citations
6.480 Impact Factor

Dickkopf-3 attenuates pressure overload-induced cardiac remodelling.

Cardiovasc Res 2014 Apr 9;102(1):35-45. Epub 2014 Jan 9.

Department of Cardiology, Renmin Hospital of Wuhan University, Jiefang Road 238, Wuhan 430060, PR China.

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http://dx.doi.org/10.1093/cvr/cvu004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6279202PMC
April 2014
31 Reads
13 Citations
5.940 Impact Factor

Growth/differentiation factor 1 alleviates pressure overload-induced cardiac hypertrophy and dysfunction.

Biochim Biophys Acta 2014 Feb 23;1842(2):232-44. Epub 2013 Nov 23.

Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan 430060, China; Cardiovascular Research Institute of Wuhan University, Wuhan 430060, China. Electronic address:

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http://dx.doi.org/10.1016/j.bbadis.2013.11.018DOI Listing
February 2014
12 Reads
1 Citation

Toll-interacting protein (Tollip) negatively regulates pressure overload-induced ventricular hypertrophy in mice.

Cardiovasc Res 2014 Jan 26;101(1):87-96. Epub 2013 Nov 26.

College of Life Sciences, Wuhan University, Wuhan 430072, PR China.

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http://dx.doi.org/10.1093/cvr/cvt232DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3968303PMC
January 2014
40 Reads
9 Citations
5.940 Impact Factor

Signal regulatory protein-α protects against cardiac hypertrophy via the disruption of toll-like receptor 4 signaling.

Hypertension 2014 Jan 7;63(1):96-104. Epub 2013 Oct 7.

Department of Cardiology, Renmin Hospital of Wuhan University, Jiefang Rd 238, Wuhan 430060, China.

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http://dx.doi.org/10.1161/HYPERTENSIONAHA.113.01506DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4422401PMC
January 2014
17 Reads
16 Citations
6.480 Impact Factor

Interferon regulatory factor 9 protects against cardiac hypertrophy by targeting myocardin.

Hypertension 2014 Jan 21;63(1):119-27. Epub 2013 Oct 21.

Department of Cardiology, Renmin Hospital of Wuhan University; Cardiovascular Research Institute, Wuhan University, Jiefang Rd 238, Wuhan 430060, PR China.

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http://dx.doi.org/10.1161/HYPERTENSIONAHA.113.02083DOI Listing
January 2014
43 Reads
21 Citations
6.480 Impact Factor

Role of interferon regulatory factor 4 in the regulation of pathological cardiac hypertrophy.

Hypertension 2013 Jun 15;61(6):1193-202. Epub 2013 Apr 15.

Department of Pharmacology and Cell Biophysics, University of Cincinnati, 231 Albert Sabin Way, Cincinnati, OH 45267-0575, USA.

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http://dx.doi.org/10.1161/HYPERTENSIONAHA.111.00614DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3734933PMC
June 2013
7 Reads
29 Citations
6.480 Impact Factor

Toll-like receptor (TLR) 2 and TLR4 differentially regulate doxorubicin induced cardiomyopathy in mice.

PLoS One 2012 13;7(7):e40763. Epub 2012 Jul 13.

Molecular Immunology and Pharmacology Group, State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, People's Republic of China.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0040763PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3396603PMC
January 2013
60 Reads
25 Citations
3.234 Impact Factor

Role of heat shock proteins in stem cell behavior.

Authors:
Guo-Chang Fan

Prog Mol Biol Transl Sci 2012 ;111:305-22

Department of Pharmacology and Cell Biophysics, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.

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http://dx.doi.org/10.1016/B978-0-12-398459-3.00014-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4422174PMC
January 2013
2 Reads
8 Citations
3.490 Impact Factor

Exosomes Function in Pro- and Anti-Angiogenesis.

Curr Angiogenes 2013 ;2(1):54-59

Department of Pharmacology and Cell Biophysics, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA.

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January 2013
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PLoS One 2012 12;7(3):e32765. Epub 2012 Mar 12.

Department of Pharmacology and Cell Biophysics, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States of America.

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August 2012
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J Biol Chem 2012 Aug 29;287(33):27480-9. Epub 2012 Jun 29.

Critical Illness Research, Lawson Health Research Institute, University of Western Ontario, London, Ontario N6A 4G5, Canada.

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August 2012
6 Reads
17 Citations
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Whether Circulating miRNAs or miRNA-Carriers Serve as Biomarkers for Acute Myocardial Infarction.

J Biomark Drug Dev 2013 2;1(1). Epub 2012 Aug 2.

Department of Pharmacology and Cell Biophysics, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA.

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http://dx.doi.org/10.4172/jbdd.1000e103DOI Listing
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August 2012
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Loss of the miR-144/451 cluster impairs ischaemic preconditioning-mediated cardioprotection by targeting Rac-1.

Cardiovasc Res 2012 May 21;94(2):379-90. Epub 2012 Feb 21.

Department of Pharmacology and Cell Biophysics, University of Cincinnati College of Medicine, Cincinnati, OH 45267-0575, USA.

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May 2012
14 Reads
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Role of microRNAs in the reperfused myocardium towards post-infarct remodelling.

Cardiovasc Res 2012 May 28;94(2):284-92. Epub 2011 Oct 28.

Department of Pharmacology and Cell Biophysics, University of Cincinnati College of Medicine, Cincinnati, OH 45267-0575, USA.

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May 2012
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The human phospholamban Arg14-deletion mutant localizes to plasma membrane and interacts with the Na/K-ATPase.

J Mol Cell Cardiol 2012 Mar 1;52(3):773-82. Epub 2011 Dec 1.

Department of Pharmacology and Cell Biophysics, University of Cincinnati, College of Medicine, Cincinnati, OH 45267-0575, USA.

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March 2012
10 Reads
16 Citations
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Mesenchymal stem cells overexpressing CXCR4 attenuate remodeling of postmyocardial infarction by releasing matrix metalloproteinase-9.

Stem Cells Dev 2012 Mar 22;21(5):778-89. Epub 2011 Jul 22.

Department of Pathology and Laboratory Medicine, University of Cincinnati Medical Center, Cincinnati, Ohio 45267-0529, USA.

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March 2012
4 Reads
14 Citations
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Paracrine effect of Wnt11-overexpressing mesenchymal stem cells on ischemic injury.

Stem Cells Dev 2012 Mar 1;21(4):598-608. Epub 2011 Jun 1.

Department of Pathology and Laboratory Medicine, University of Cincinnati Medical Center, Cincinnati, Ohio 45267, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3156900PMC
March 2012
22 Reads
12 Citations
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Small heat shock protein 20 (HspB6) in cardiac hypertrophy and failure.

J Mol Cell Cardiol 2011 Oct 30;51(4):574-7. Epub 2010 Sep 30.

Department of Pharmacology and Cell Biophysics, University of Cincinnati College of Medicine, Cincinnati, OH 45267-0575, USA.

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http://dx.doi.org/10.1016/j.yjmcc.2010.09.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3033453PMC
October 2011
4 Reads
26 Citations
4.660 Impact Factor

Extracellular/circulating microRNAs and their potential role in cardiovascular disease.

Am J Cardiovasc Dis 2011 Jul;1(2):138-149

Department of Pharmacology and Cell Biophysics, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA.

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July 2011
42 Reads
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Small heat shock protein 20 interacts with protein phosphatase-1 and enhances sarcoplasmic reticulum calcium cycling.

Circ Res 2011 Jun 14;108(12):1429-38. Epub 2011 Apr 14.

Department of Pharmacology and Cell Biophysics, University of Cincinnati College of Medicine, 231 Albert Sabin Way, Cincinnati, OH 45267-0575, USA.

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June 2011
48 Reads
22 Citations
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Synergistic effects of the GATA-4-mediated miR-144/451 cluster in protection against simulated ischemia/reperfusion-induced cardiomyocyte death.

J Mol Cell Cardiol 2010 Nov 11;49(5):841-50. Epub 2010 Aug 11.

Department of Pharmacology and Cell Biophysics, University of Cincinnati College of Medicine, Cincinnati, OH 45267-0575, USA.

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November 2010
5 Reads
62 Citations
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Expression of active protein phosphatase 1 inhibitor-1 attenuates chronic beta-agonist-induced cardiac apoptosis.

Basic Res Cardiol 2010 Sep 30;105(5):573-81. Epub 2010 May 30.

Department of Pharmacology and Cell Biophysics, University of Cincinnati College of Medicine, OH 45267-0575, USA.

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September 2010
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15 Citations
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MicroRNA-494 targeting both proapoptotic and antiapoptotic proteins protects against ischemia/reperfusion-induced cardiac injury.

Circulation 2010 Sep 13;122(13):1308-18. Epub 2010 Sep 13.

Department of Pharmacology and Cell Biophysics, University of Cincinnati College of Medicine, 231 Albert Sabin Way, Cincinnati, OH 45267-0575, USA.

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September 2010
16 Reads
91 Citations
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Gene manipulated peritoneal cell patch repairs infarcted myocardium.

J Mol Cell Cardiol 2010 Apr 11;48(4):702-12. Epub 2009 Nov 11.

Department of Pathology and Laboratory Medicine, College of Medicine, University of Cincinnati Medical Center, Cincinnati, OH 45267, USA.

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April 2010
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13 Citations
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Hsp20-engineered mesenchymal stem cells are resistant to oxidative stress via enhanced activation of Akt and increased secretion of growth factors.

Stem Cells 2009 Dec;27(12):3021-31

Department of Pharmacology and Cell Biophysics, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267-0575, USA.

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December 2009
39 Reads
67 Citations
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Blockade of Hsp20 phosphorylation exacerbates cardiac ischemia/reperfusion injury by suppressed autophagy and increased cell death.

Circ Res 2009 Dec 22;105(12):1223-31. Epub 2009 Oct 22.

Department of Pharmacology and Cell Biophysics, University of Cincinnati College of Medicine, 231 Albert Sabin Way, Cincinnati, OH 45267-0575, USA.

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December 2009
31 Reads
36 Citations
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Overexpression of Hsp20 prevents endotoxin-induced myocardial dysfunction and apoptosis via inhibition of NF-kappaB activation.

J Mol Cell Cardiol 2009 Sep 6;47(3):382-90. Epub 2009 Jun 6.

Department of Pharmacology and Cell Biophysics, University of Cincinnati College of Medicine, Cincinnati, OH 45267-0575, USA.

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September 2009
21 Reads
21 Citations
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Protection of peroxiredoxin II on oxidative stress-induced cardiomyocyte death and apoptosis.

Basic Res Cardiol 2009 Jul 22;104(4):377-89. Epub 2008 Nov 22.

Dept. of Pharmacology and Cell Biophysics, University of Cincinnati College of Medicine, 231 Albert Sabin Way, Cincinnati, OH 45267-0575, USA.

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July 2009
3 Reads
16 Citations
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MicroRNA-320 is involved in the regulation of cardiac ischemia/reperfusion injury by targeting heat-shock protein 20.

Circulation 2009 May 20;119(17):2357-2366. Epub 2009 Apr 20.

Department of Pharmacology and Cell Biophysics, University of Cincinnati College of Medicine, Cincinnati, OH 45267.

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May 2009
33 Reads
150 Citations
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Human mutation in the anti-apoptotic heat shock protein 20 abrogates its cardioprotective effects.

J Biol Chem 2008 Nov 12;283(48):33465-71. Epub 2008 Sep 12.

Department of Pharmacology and Cell Biophysics, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267-0575, USA.

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November 2008
7 Reads
18 Citations
4.573 Impact Factor

Heat shock protein 20 interacting with phosphorylated Akt reduces doxorubicin-triggered oxidative stress and cardiotoxicity.

Circ Res 2008 Nov 23;103(11):1270-9. Epub 2008 Oct 23.

Department of Pharmacology and Cell Biophysics, University of Cincinnati College of Medicine, 231 Albert Sabin Way, Cincinnati, OH 45267-0575, USA.

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November 2008
26 Reads
46 Citations
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A human polymorphism of protein phosphatase-1 inhibitor-1 is associated with attenuated contractile response of cardiomyocytes to beta-adrenergic stimulation.

FASEB J 2008 Jun 11;22(6):1790-6. Epub 2008 Jan 11.

Department of Pharmacology and Cell Biophysics, University of Cincinnati, College of Medicine, 231 Albert Sabin Way, Cincinnati, OH 45267-0575, USA.

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http://dx.doi.org/10.1096/fj.07-097428DOI Listing
June 2008
14 Reads
9 Citations
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A human phospholamban promoter polymorphism in dilated cardiomyopathy alters transcriptional regulation by glucocorticoids.

Hum Mutat 2008 May;29(5):640-7

Department of Pharmacology and Cell Biophysics, University of Cincinnati, College of Medicine, Cincinnati, Ohio 45267-0575, USA.

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May 2008
7 Reads
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Over-expression of CXCR4 on mesenchymal stem cells augments myoangiogenesis in the infarcted myocardium.

J Mol Cell Cardiol 2008 Feb 7;44(2):281-92. Epub 2007 Dec 7.

Department of Pathology and Laboratory Medicine, University of Cincinnati Medical Center, 231 Albert Sabin Way, Cincinnati, OH 45267-0529, USA.

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February 2008
42 Reads
78 Citations
4.660 Impact Factor

Regulatory roles of junctin in sarcoplasmic reticulum calcium cycling and myocardial function.

Trends Cardiovasc Med 2008 Jan;18(1):1-5

Department of Pharmacology and Cell Biophysics, University of Cincinnati College of Medicine, Cincinnati, OH 45267-0575, USA.

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http://dx.doi.org/10.1016/j.tcm.2007.10.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2593792PMC
January 2008
2 Reads
4 Citations
2.910 Impact Factor

Histidine-rich Ca-binding protein interacts with sarcoplasmic reticulum Ca-ATPase.

Am J Physiol Heart Circ Physiol 2007 Sep 25;293(3):H1581-9. Epub 2007 May 25.

Molecular Biology Division, Center for Basic Research, Foundation for Biomedical Research of the Academy of Athens, Athens, Greece.

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http://dx.doi.org/10.1152/ajpheart.00278.2007DOI Listing
September 2007
13 Reads
37 Citations
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Overexpression of histidine-rich Ca-binding protein protects against ischemia/reperfusion-induced cardiac injury.

Cardiovasc Res 2007 Aug 19;75(3):487-97. Epub 2007 Apr 19.

Department of Pharmacology and Cell Biophysics, University of Cincinnati College of Medicine, Cincinnati, OH 45267-0575, USA.

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August 2007
9 Reads
7 Citations
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Sarcoplasmic reticulum calcium overloading in junctin deficiency enhances cardiac contractility but increases ventricular automaticity.

Circulation 2007 Jan 15;115(3):300-9. Epub 2007 Jan 15.

Department of Pharmacology and Cell Biophysics, University of Cincinnati College of Medicine, Cincinnati, OH 45267-0575, USA.

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January 2007
13 Reads
43 Citations
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Junctin is a prominent regulator of contractility in cardiomyocytes.

Biochem Biophys Res Commun 2007 Jan 27;352(3):617-22. Epub 2006 Nov 27.

Department of Pharmacology and Cell Biophysics, University of Cincinnati College of Medicine, Cincinnati, OH 45267-0575, USA.

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http://dx.doi.org/10.1016/j.bbrc.2006.11.093DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2361429PMC
January 2007
49 Reads
9 Citations
2.300 Impact Factor

Small heat-shock protein Hsp20 attenuates beta-agonist-mediated cardiac remodeling through apoptosis signal-regulating kinase 1.

Circ Res 2006 Nov 26;99(11):1233-42. Epub 2006 Oct 26.

Department of Pharmacology and Cell Biophysics, University of Cincinnati College of Medicine, Ohio 45267-0575, USA.

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November 2006
10 Reads
32 Citations
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A mutation in the human phospholamban gene, deleting arginine 14, results in lethal, hereditary cardiomyopathy.

Proc Natl Acad Sci U S A 2006 Jan 23;103(5):1388-93. Epub 2006 Jan 23.

Department of Pharmacology and Cell Biophysics, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA.

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January 2006
41 Reads
84 Citations
9.810 Impact Factor

Hsp20 and its cardioprotection.

Trends Cardiovasc Med 2005 May;15(4):138-41

Department of Pharmacology and Cell Biophysics, University of Cincinnati College of Medicine, 231 Albert Sabin Way, Cincinnati, OH 45267, USA.

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http://dx.doi.org/10.1016/j.tcm.2005.05.004DOI Listing
May 2005
15 Reads
31 Citations
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Novel cardioprotective role of a small heat-shock protein, Hsp20, against ischemia/reperfusion injury.

Circulation 2005 Apr 4;111(14):1792-9. Epub 2005 Apr 4.

Department of Pharmacology and Cell Biophysics, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267-0575, USA.

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http://dx.doi.org/10.1161/01.CIR.0000160851.41872.C6DOI Listing
April 2005
28 Reads
52 Citations
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Regulation of myocardial function by histidine-rich, calcium-binding protein.

Am J Physiol Heart Circ Physiol 2004 Oct 10;287(4):H1705-11. Epub 2004 Jun 10.

Dept. of Pharmacology and Cell Biophysics, University of Cincinnati College of Medicine, 231 Albert Sabin Way, Cincinnati, OH 45267-0575, USA.

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http://dx.doi.org/10.1152/ajpheart.01211.2003DOI Listing
October 2004
6 Reads
28 Citations
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Small heat-shock protein Hsp20 phosphorylation inhibits beta-agonist-induced cardiac apoptosis.

Circ Res 2004 Jun 22;94(11):1474-82. Epub 2004 Apr 22.

Department of Pharmacology and Cell Biophysics, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267-0575, USA.

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June 2004
4 Reads
40 Citations
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Phosphoproteome analysis of cardiomyocytes subjected to beta-adrenergic stimulation: identification and characterization of a cardiac heat shock protein p20.

Circ Res 2004 Feb 13;94(2):184-93. Epub 2003 Nov 13.

Department of Pharmacology and Cell Biophysics, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267-0575, USA.

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February 2004
47 Reads
15 Citations
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Vaccination with minigenes encoding V(H)-derived major histocompatibility complex class I-binding epitopes activates cytotoxic T cells that ablate autoantibody-producing B cells and inhibit lupus.

J Exp Med 2002 Sep;196(6):731-41

Autoimmunity and Tolerance Laboratory, Division of Immunology, Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, OH 45267-0563, USA.

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http://dx.doi.org/10.1084/jem.20020223DOI Listing
September 2002
7 Reads
22 Citations
12.520 Impact Factor

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