Dr. Gunnar K Gouras - Lund University - Professor of Experimental Neurology

Dr. Gunnar K Gouras

Lund University

Professor of Experimental Neurology

Lund | Sweden

Main Specialties: Neurology

Additional Specialties: dementia, behavioural neurology

ORCID logohttps://orcid.org/0000-0002-5500-6325

Dr. Gunnar K Gouras - Lund University - Professor of Experimental Neurology

Dr. Gunnar K Gouras

Introduction

Gunnar Keppler Gouras (GK Gouras or G Gouras in papers) is Professor of Experimental Neurology & head of the Neurobiology section in the Department of Experimental Medical Science, Lund University in Lund, Sweden. His research focuses on the cellular and synaptic biology and pathology of Alzheimer’s disease (AD)-linked beta-amyloid (Abeta). Abeta was traditionally viewed as an extracellular peptide that abnormally aggregates in AD. His publication Gouras GK et al., 2000, provided the first evidence that particularly disease-linked Abeta accumulates early within vulnerable neurons in AD. Utilising immuno-electron microscopy his group then discovered that Abeta localises to multivesicular bodies and with AD preferentially accumulates and aggregates in synaptic terminals, providing the 1st physical link between Abeta and synapses (Takahashi RH et al., 2002; 2004, 2010).

Primary Affiliation: Lund University - Lund , Sweden

Specialties:

Additional Specialties:

Research Interests:

Metrics

Number of Publications

52

Publications

Number of Profile Views

303

Profile Views

Number of Article Reads

377

Reads

Number of PubMed Central Citations

2243

PubMed Central Citations

Education

Jan 1985 - May 1989
Columbia University
Doctor of Medicine

Experience

Jan 2008 - Jan 2011
Weill Cornell Medical College
Professor
May 2011
Lund University
Professor

Publications

52Publications

377Reads

2243PubMed Central Citations

Prion-like seeding and nucleation of intracellular amyloid-β.

Neurobiol Dis 2018 May 4;113:1-10. Epub 2018 Feb 4.

Experimental Dementia Research Unit, Dept. of Experimental Medical Science, Lund University, Lund, Sweden. Electronic address:

View Article
May 2018
2 Reads
2 PubMed Central Citations(source)
5.080 Impact Factor

Dysregulation of Elongation Factor 1A Expression is Correlated with Synaptic Plasticity Impairments in Alzheimer's Disease.

J Alzheimers Dis 2016 09;54(2):669-78

Sticht Center on Aging, Department of Internal Medicine-Gerontology and Geriatric Medicine, Wake Forest University School of Medicine, Winston-Salem, NC, USA.

View Article
September 2016
7 Reads
2 PubMed Central Citations(source)
4.150 Impact Factor

Direct High Affinity Interaction between Aβ42 and GSK3α Stimulates Hyperphosphorylation of Tau. A New Molecular Link in Alzheimer's Disease?

ACS Chem Neurosci 2016 Feb 15;7(2):161-70. Epub 2015 Dec 15.

Department of Biochemistry and Structural Biology, Chemical Centre, Lund University , P O Box 124, SE22100 Lund, Sweden.

View Article
February 2016
5 Reads
6 PubMed Central Citations(source)
4.360 Impact Factor

ADAM10 and BACE1 are localized to synaptic vesicles.

J Neurochem 2015 Nov 17;135(3):606-15. Epub 2015 Sep 17.

Karolinska Institutet, Department of Neurobiology, Care Science and Society, Division of Neurogeriatrics, Center for Alzheimer Research, Huddinge, Sweden.

View Article
November 2015
8 Reads
9 PubMed Central Citations(source)
4.280 Impact Factor

ESCRTs regulate amyloid precursor protein sorting in multivesicular bodies and intracellular amyloid-β accumulation.

J Cell Sci 2015 Jul 22;128(14):2520-8. Epub 2015 May 22.

Department of Cell Biology, UCL Institute of Ophthalmology, London EC1 V9EL, UK

View Article
July 2015
12 Reads
14 PubMed Central Citations(source)
5.430 Impact Factor

β-Amyloid peptides and amyloid plaques in Alzheimer's disease.

Neurotherapeutics 2015 Jan;12(1):3-11

Department of Experimental Medical Science, Lund University, Lund, Sweden,

View Article
January 2015
18 Reads
4 PubMed Central Citations(source)

The inside-out amyloid hypothesis and synapse pathology in Alzheimer's disease.

Neurodegener Dis 2014 24;13(2-3):142-6. Epub 2013 Sep 24.

Experimental Dementia Research Unit, Wallenberg Neuroscience Center, Department of Experimental Medical Science, Lund University, Lund, Sweden.

View Article
September 2014
2 Reads
8 PubMed Central Citations(source)
3.510 Impact Factor

Convergence of synapses, endosomes, and prions in the biology of neurodegenerative diseases.

Authors:
Gunnar K Gouras

Int J Cell Biol 2013 7;2013:141083. Epub 2013 Nov 7.

Department of Experimental Medical Science, Experimental Dementia Research Unit, Wallenberg Neuroscience Center, Lund University, 221 84 Lund, Sweden.

View Article
June 2014
2 Reads
5 PubMed Central Citations(source)

Activity-independent release of the amyloid β-peptide from rat brain nerve terminals.

Neurosci Lett 2014 Apr 3;566:125-30. Epub 2014 Mar 3.

Karolinska Institutet, Department of Neurobiology, Care Science and Society, Center for Alzheimer Research, Novum level 5, 141 86 Stockholm, Sweden. Electronic address:

View Article
April 2014
4 Reads
4 PubMed Central Citations(source)
2.060 Impact Factor

Lesion of the subiculum reduces the spread of amyloid beta pathology to interconnected brain regions in a mouse model of Alzheimer's disease.

Acta Neuropathol Commun 2014 Feb 11;2:17. Epub 2014 Feb 11.

Neuronal Survival Unit, Department of Experimental Medical Science, Wallenberg Neuroscience Center, Lund University, Lund, Sweden.

View Article
February 2014
6 Reads
5 PubMed Central Citations(source)

Nonsteroidal selective androgen receptor modulators and selective estrogen receptor β agonists moderate cognitive deficits and amyloid-β levels in a mouse model of Alzheimer's disease.

ACS Chem Neurosci 2013 Dec 25;4(12):1537-48. Epub 2013 Sep 25.

Neuronal Survival Unit, Department of Experimental Medical Science, Wallenberg Neuroscience Center, Lund University , Lund S-22184, Sweden.

View Article
December 2013
9 Reads
8 PubMed Central Citations(source)
4.360 Impact Factor

Accumulation of intraneuronal β-amyloid 42 peptides is associated with early changes in microtubule-associated protein 2 in neurites and synapses.

PLoS One 2013 23;8(1):e51965. Epub 2013 Jan 23.

Department of Anatomic Pathology, Tokyo Medical University, Tokyo, Japan.

View Article
July 2013
4 Reads
10 PubMed Central Citations(source)
3.230 Impact Factor

Pathology of synapses and dendritic spines.

Neural Plast 2012 23;2012:972432. Epub 2012 Sep 23.

View Article
June 2013
7 Reads
1 PubMed Central Citation(source)

mTOR: at the crossroads of aging, chaperones, and Alzheimer's disease.

Authors:
Gunnar K Gouras

J Neurochem 2013 Mar 26;124(6):747-8. Epub 2012 Dec 26.

View Article
March 2013
1 Read
4 PubMed Central Citations(source)
4.280 Impact Factor

Critical role of intraneuronal Aβ in Alzheimer's disease: technical challenges in studying intracellular Aβ.

Life Sci 2012 Dec 19;91(23-24):1153-8. Epub 2012 Jun 19.

Experimental Dementia Research Unit, BMC-B12, Wallenberg Neuroscience Center, Department of Experimental Medical Science, Lund University, Sölvegatan 19, 221 84 Lund, Sweden.

View Article
December 2012
10 Reads
14 PubMed Central Citations(source)
2.700 Impact Factor

Intraneuronal Aβ accumulation, amyloid plaques, and synapse pathology in Alzheimer's disease.

Neurodegener Dis 2012 21;10(1-4):56-9. Epub 2012 Jan 21.

Department of Neurology and Neuroscience, Weill Cornell Medical College, New York, NY 10065, USA.

View Article
August 2012
4 Reads
4 PubMed Central Citations(source)
3.510 Impact Factor

Coenzyme Q10 decreases amyloid pathology and improves behavior in a transgenic mouse model of Alzheimer's disease.

J Alzheimers Dis 2011 ;27(1):211-23

Department of Neurology and Neuroscience, Weill Cornell Medical College, New York, NY 10065, USA.

View Article
February 2012
6 Reads
14 PubMed Central Citations(source)
4.150 Impact Factor

Analysis of vesicular trafficking in primary neurons by live imaging.

Methods Mol Biol 2011 ;793:343-50

Experimental Dementia Research Unit, Department of Experimental Medical Science, Wallenberg Neuroscience Center, Lund University, Lund, Sweden.

View Article
December 2011
4 Reads

High-resolution 3D reconstruction reveals intra-synaptic amyloid fibrils.

Am J Pathol 2011 Nov 15;179(5):2551-8. Epub 2011 Sep 15.

Department of Neurology and Neuroscience, Weill Cornell Medical College, New York, New York, USA.

View Article
November 2011
6 Reads
8 PubMed Central Citations(source)
4.590 Impact Factor

Impaired β-amyloid secretion in Alzheimer's disease pathogenesis.

J Neurosci 2011 Oct;31(43):15384-90

Department of Neurology and Neuroscience, Weill Cornell Medical College, New York, New York 10065, USA.

View Article
October 2011
4 Reads
16 PubMed Central Citations(source)
6.340 Impact Factor

Synapses, synaptic activity and intraneuronal abeta in Alzheimer's disease.

Front Aging Neurosci 2010 21;2. Epub 2010 May 21.

Department of Neurology and Neuroscience, Weill Cornell Medical College New York, NY, USA.

View Article
July 2011
19 Reads
26 PubMed Central Citations(source)
2.840 Impact Factor

Accumulation of cellular prion protein within dystrophic neurites of amyloid plaques in the Alzheimer's disease brain.

Neuropathology 2011 Jun 9;31(3):208-14. Epub 2010 Nov 9.

Department of Anatomic Pathology, Tokyo Medical University, Shinjuku-ku, Tokyo, Japan.

View Article
June 2011
9 Reads
9 PubMed Central Citations(source)
1.800 Impact Factor

Degradation of Alzheimer's amyloid fibrils by microglia requires delivery of ClC-7 to lysosomes.

Mol Biol Cell 2011 May 25;22(10):1664-76. Epub 2011 Mar 25.

Department of Biochemistry and Weill Cornell Medical College, New York, NY 10065, USA.

View Article
May 2011
2 Reads
19 PubMed Central Citations(source)
4.470 Impact Factor

Effects of synaptic modulation on beta-amyloid, synaptophysin, and memory performance in Alzheimer's disease transgenic mice.

J Neurosci 2010 Oct;30(43):14299-304

Department of Neurology and Neuroscience, Weill Cornell Medical College, New York, New York 10065, USA.

View Article
October 2010
4 Reads
38 PubMed Central Citations(source)
6.340 Impact Factor

Dysregulation of the mTOR pathway mediates impairment of synaptic plasticity in a mouse model of Alzheimer's disease.

PLoS One 2010 Sep 20;5(9). Epub 2010 Sep 20.

Department of Neurology and Neuroscience, Weill Cornell Medical College, New York, New York, USA.

View Article
September 2010
19 Reads
76 PubMed Central Citations(source)
3.230 Impact Factor

Co-occurrence of Alzheimer's disease ß-amyloid and τ pathologies at synapses.

Neurobiol Aging 2010 Jul 3;31(7):1145-52. Epub 2008 Sep 3.

Department of Neurology & Neuroscience, Weill Cornell Medical College, 525 East 68th Street, New York, NY 10065, USA.

View Article
July 2010
8 Reads
42 PubMed Central Citations(source)
5.010 Impact Factor

Intraneuronal beta-amyloid accumulation and synapse pathology in Alzheimer's disease.

Acta Neuropathol 2010 May 31;119(5):523-41. Epub 2010 Mar 31.

Department for Neurology and Neuroscience, Weill Cornell Medical College, New York, NY 10065, USA.

View Article
May 2010
7 Reads
97 PubMed Central Citations(source)
10.760 Impact Factor

Immunotherapy for Alzheimer disease.

Authors:
Gunnar K Gouras

MAbs 2009 Mar-Apr;1(2):112-4. Epub 2009 Mar 11.

Department of Neurology and Neuroscience, Weill Cornell Medical College, New York, NY 10065, USA.

View Article
March 2010
2 Reads
1 PubMed Central Citation(source)
4.560 Impact Factor

Synaptic activity reduces intraneuronal Abeta, promotes APP transport to synapses, and protects against Abeta-related synaptic alterations.

J Neurosci 2009 Aug;29(31):9704-13

Department of Neurology and Neuroscience, Weill Medical College of Cornell University, New York, New York 10065, USA.

View Article
August 2009
5 Reads
51 PubMed Central Citations(source)
6.340 Impact Factor

Triterpenoid CDDO-methylamide improves memory and decreases amyloid plaques in a transgenic mouse model of Alzheimer's disease.

J Neurochem 2009 Apr 7;109(2):502-12. Epub 2009 Feb 7.

Department of Neurology and Neuroscience, Weill Cornell Medical College, New York, New York 10065, USA.

View Article
April 2009
6 Reads
39 PubMed Central Citations(source)
4.280 Impact Factor

Optical visualization of Alzheimer's pathology via multiphoton-excited intrinsic fluorescence and second harmonic generation.

Opt Express 2009 Mar;17(5):3679-89

School of Applied and Engineering Physics, Cornell University, Ithaca, New York 14853, USA.

View Article
March 2009
5 Reads
14 PubMed Central Citations(source)
3.490 Impact Factor

Beta-amyloid modulation of synaptic transmission and plasticity.

J Neurosci 2007 Oct;27(44):11832-7

Child Study Center, Yale University School of Medicine, New Haven, Connecticut 06520, USA.

View Article
October 2007
4 Reads
46 PubMed Central Citations(source)
6.340 Impact Factor

Internalized antibodies to the Abeta domain of APP reduce neuronal Abeta and protect against synaptic alterations.

J Biol Chem 2007 Jun 27;282(26):18895-906. Epub 2007 Apr 27.

Department of Neurology and Neuroscience, Weill Medical College of Cornell University, New York, New York 10021, USA.

View Article
June 2007
6 Reads
52 PubMed Central Citations(source)
4.570 Impact Factor

The Arctic Alzheimer mutation favors intracellular amyloid-beta production by making amyloid precursor protein less available to alpha-secretase.

J Neurochem 2007 May;101(3):854-62

Department of Public Health and Caring Sciences, Rudbeck Laboratory, Uppsala University, Uppsala, Sweden.

View Article
May 2007
11 Reads
20 PubMed Central Citations(source)
4.280 Impact Factor

Beta-amyloid accumulation impairs multivesicular body sorting by inhibiting the ubiquitin-proteasome system.

J Neurosci 2006 Apr;26(16):4277-88

Department of Neurology and Neuroscience, Weill Medical College of Cornell University, New York, New York 10021, USA.

View Article
April 2006
5 Reads
80 PubMed Central Citations(source)
6.340 Impact Factor

Intraneuronal beta-amyloid expression downregulates the Akt survival pathway and blunts the stress response.

J Neurosci 2005 Nov;25(47):10960-9

Department of Neurology, Caritas Saint Elizabeth's Medical Center, Tufts University School of Medicine, Boston, Massachusetts 02135, USA.

View Article
November 2005
3 Reads
28 PubMed Central Citations(source)
6.340 Impact Factor

Beta-amyloid accumulation in APP mutant neurons reduces PSD-95 and GluR1 in synapses.

Neurobiol Dis 2005 Nov;20(2):187-98

Department of Neurology and Neuroscience, Laboratory of Alzheimer's Disease Neurobiology, Weill Medical College of Cornell University, 525 E 68th Street, NY 10021, USA.

View Article
November 2005
5 Reads
129 PubMed Central Citations(source)
5.080 Impact Factor

Intraneuronal Abeta accumulation and origin of plaques in Alzheimer's disease.

Neurobiol Aging 2005 Oct;26(9):1235-44

Laboratory of Alzheimer's disease Neurobiology, Department of Neurology & Neuroscience, Weill Medical College of Cornell University, 525 East 68th Street, New York, NY 10021, USA.

View Article
October 2005
6 Reads
97 PubMed Central Citations(source)
5.010 Impact Factor

Regulation of NMDA receptor trafficking by amyloid-beta.

Nat Neurosci 2005 Aug 17;8(8):1051-8. Epub 2005 Jul 17.

Laboratory for Molecular and Cellular Neuroscience, Rockefeller University, 1230 York Avenue, New York, New York 10021, USA.

View Article
August 2005
3 Reads
473 PubMed Central Citations(source)
16.090 Impact Factor

Conditional inactivation of presenilin 1 prevents amyloid accumulation and temporarily rescues contextual and spatial working memory impairments in amyloid precursor protein transgenic mice.

J Neurosci 2005 Jul;25(29):6755-64

Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA.

View Article
July 2005
40 Reads
57 PubMed Central Citations(source)
6.340 Impact Factor

Amyloid-beta oligomers are inefficiently measured by enzyme-linked immunosorbent assay.

Ann Neurol 2005 Jul;58(1):147-50

Department of Public Health/Geriatrics, Rudbeck Laboratory, Uppsala University, Uppsala, Sweden.

View Article
July 2005
26 Reads
35 PubMed Central Citations(source)
9.980 Impact Factor

Increased plaque burden in brains of APP mutant MnSOD heterozygous knockout mice.

J Neurochem 2004 Jun;89(5):1308-12

Department of Neurology and Neuroscience, Weill Medical College of Cornell University, 525 East 68th Street, New York, NY 10021, USA.

View Article
June 2004
23 Reads
99 PubMed Central Citations(source)
4.280 Impact Factor

Oligomerization of Alzheimer's beta-amyloid within processes and synapses of cultured neurons and brain.

J Neurosci 2004 Apr;24(14):3592-9

Department of Neurology and Neuroscience, Weill Medical College of Cornell University, New York, New York 10021, USA.

View Article
April 2004
8 Reads
119 PubMed Central Citations(source)
6.340 Impact Factor

Chaperones increase association of tau protein with microtubules.

Proc Natl Acad Sci U S A 2003 Jan 9;100(2):721-6. Epub 2003 Jan 9.

Fisher Center for Research on Alzheimer's Disease, Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA.

View Article
January 2003
13 Reads
134 PubMed Central Citations(source)
9.810 Impact Factor

Intraneuronal Alzheimer abeta42 accumulates in multivesicular bodies and is associated with synaptic pathology.

Am J Pathol 2002 Nov;161(5):1869-79

Department of Neurology and Neuroscience, Weill Medical College of Cornell University, New York, New York 10021, USA.

View Article
November 2002
9 Reads
191 PubMed Central Citations(source)
4.590 Impact Factor

Alzheimer beta-amyloid peptides: normal and abnormal localization.

Histol Histopathol 2002 01;17(1):239-46

Department of Neurology and Neuroscience, Weill Medical College of Cornell University, New York, NY 10021, USA.

View Article
January 2002
11 PubMed Central Citations(source)
2.100 Impact Factor

Stimulation of beta-amyloid precursor protein trafficking by insulin reduces intraneuronal beta-amyloid and requires mitogen-activated protein kinase signaling.

J Neurosci 2001 Apr;21(8):2561-70

Laboratory of Molecular and Cellular Neuroscience, Fisher Center for Research on Alzheimer Disease, and Laboratory for Mass Spectrometry, The Rockefeller University, New York, New York 10021, USA.

View Article
April 2001
92 PubMed Central Citations(source)
6.340 Impact Factor

Generation and regulation of beta-amyloid peptide variants by neurons.

J Neurochem 1998 Nov;71(5):1920-5

Memory Disorders Center, Department of Neurology and Neuroscience, Cornell University Medical College, New York, New York, USA.

View Article
November 1998
27 PubMed Central Citations(source)
4.280 Impact Factor

Cellular and molecular basis of beta-amyloid precursor protein metabolism.

Front Biosci 1998 Mar 26;3:d399-407. Epub 1998 Mar 26.

Department of Neurology and Neuroscience, Cornell University Medical College, The Rockefeller University, New York NY 10021, USA.

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March 1998
2 PubMed Central Citations(source)

Biologic effects of nerve growth factor on lesioned basal forebrain neurons.

Ann N Y Acad Sci 1991 ;640:102-9

Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205-2181.

View Article
February 1992
4.310 Impact Factor