Guillermo Gervasini

Guillermo Gervasini

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Guillermo Gervasini

Guillermo Gervasini

Publications by authors named "Guillermo Gervasini"

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Pharmacogenetics and personalized medicine. Are expectations being met?

Med Clin (Barc) 2019 May 2;152(9):368-371. Epub 2019 Jan 2.

Departamento de Terapéutica Médico-Quirúrgica, Facultad de Medicina, Universidad de Extremadura, Badajoz, España. Electronic address:

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http://dx.doi.org/10.1016/j.medcli.2018.12.001DOI Listing
May 2019

Variability in the leptin receptor gene and other risk factors for post-transplant diabetes mellitus in renal transplant recipients.

Ann Med 2019 Mar 1;51(2):164-173. Epub 2019 Jun 1.

a Department of Medical and Surgical Therapeutics, Division of Pharmacology, Medical School , University of Extremadura , Badajoz , Spain.

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http://dx.doi.org/10.1080/07853890.2019.1614656DOI Listing
March 2019

Clinical Implications of Methotrexate Pharmacogenetics in Childhood Acute Lymphoblastic Leukaemia.

Curr Drug Metab 2019 ;20(4):313-330

Department of Medical & Surgical Therapeutics, Medical School, University of Extremadura, Av. Elvas s/n 06006, Badajoz, Spain.

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http://dx.doi.org/10.2174/1389200220666190130161758DOI Listing
January 2019

Polymorphisms in genes involved in vasoactive eicosanoid synthesis affect cardiovascular risk in renal transplant recipients.

Curr Med Res Opin 2018 02 8;34(2):247-253. Epub 2017 Nov 8.

b Service of Nephrology, Infanta Cristina University Hospital , Badajoz , Spain.

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http://dx.doi.org/10.1080/03007995.2017.1391757DOI Listing
February 2018

Dihydrofolate Reductase Genetic Polymorphisms Affect Methotrexate Dose Requirements in Pediatric Patients With Acute Lymphoblastic Leukemia on Maintenance Therapy.

J Pediatr Hematol Oncol 2017 11;39(8):589-595

*Department of Medical and Surgical Therapeutics, Division of Pharmacology, Medical School, University of Extremadura †Service of Pediatric Hematology, Materno Infantil Hospital, Badajoz, Spain.

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http://dx.doi.org/10.1097/MPH.0000000000000908DOI Listing
November 2017

Effect of polymorphisms in transporter genes on dosing, efficacy and toxicity of maintenance therapy in children with acute lymphoblastic leukemia.

Gene 2017 Sep 12;628:72-77. Epub 2017 Jul 12.

Service of Pediatric Hematology, Materno Infantil Hospital, Badajoz, Spain.

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http://dx.doi.org/10.1016/j.gene.2017.07.025DOI Listing
September 2017

Influence of and genetic variability on personality dimensions in anorexia and bulimia nervosa.

Brain Behav 2017 09 27;7(9):e00784. Epub 2017 Jul 27.

Department of Medical & Surgical Therapeutics Division of Pharmacology Medical School University of Extremadura Badajoz Spain.

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http://dx.doi.org/10.1002/brb3.784DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5607548PMC
September 2017

Polymorphisms in the SNRPN gene are associated with obesity susceptibility in a Spanish population.

J Gene Med 2017 May;19(5)

Genomics Group, Fundación Investigación Hospital General Universitario de Valencia, Valencia, Spain.

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http://dx.doi.org/10.1002/jgm.2956DOI Listing
May 2017

Potential beneficial effects of sacubitril-valsartan in renal disease: a new field for a new drug.

Expert Opin Investig Drugs 2017 May 21;26(5):651-659. Epub 2017 Apr 21.

b Service of Nephrology , Infanta Cristina University Hospital , Badajoz , Spain.

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http://dx.doi.org/10.1080/13543784.2017.1317345DOI Listing
May 2017

Polymorphisms in ABCB1 and CYP19A1 genes affect anastrozole plasma concentrations and clinical outcomes in postmenopausal breast cancer patients.

Br J Clin Pharmacol 2017 03 18;83(3):562-571. Epub 2016 Oct 18.

Department of Medical and Surgical Therapeutics, Division of Clinical Pharmacology, Medical School, University of Extremadura, Alcorcón, Madrid, Spain.

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http://dx.doi.org/10.1111/bcp.13130DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5306492PMC
March 2017

Etiopathological mechanisms and clinical characteristics of hyperhemolysis syndrome in Spanish patients with thalassemia.

Ann Hematol 2016 Sep 9;95(9):1419-27. Epub 2016 Jul 9.

Department of Surgical and Medical Therapeutics, School of Medicine, University of Extremadura, Av. Elvas s/n 06071, Badajoz, Spain.

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http://dx.doi.org/10.1007/s00277-016-2733-8DOI Listing
September 2016

Discussing the putative role of obesity-associated genes in the etiopathogenesis of eating disorders.

Pharmacogenomics 2015 12;16(11):1287-1305. Epub 2015 Aug 12.

Department of Medical & Surgical Therapeutics, Division of Pharmacology, Medical School, University of Extremadura, Av. Elvas s/n, E-06005, Badajoz, Spain.

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http://dx.doi.org/10.2217/pgs.15.77DOI Listing
June 2016

Polymorphisms in CYP-mediated arachidonic acid routes affect the outcome of renal transplantation.

Eur J Clin Invest 2015 Oct 24;45(10):1060-8. Epub 2015 Aug 24.

Service of Immunology, Infanta Cristina University Hospital, Badajoz, Spain.

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http://dx.doi.org/10.1111/eci.12507DOI Listing
October 2015

Functional consequences of transferrin receptor-2 mutations causing hereditary hemochromatosis type 3.

Mol Genet Genomic Med 2015 May 6;3(3):221-32. Epub 2015 Mar 6.

Cancer and Iron Group and Advanced Genetic Diagnostic Unit of Rare Iron Disorders (UDGAEMH), Institut of Predictive and Personalized Medicine of Cancer (IMPPC) Barcelona, Spain ; Diagnostics in Iron Metabolism Service (D·IRON) and Iron Metabolism: Regulation and Diseases group, Josep Carreras Leukemia Research Institute (IJC) Barcelona, Spain.

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http://dx.doi.org/10.1002/mgg3.136DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4444164PMC
May 2015

Clinical relevance of erythrocyte ferritin in microcytic anemias.

Clin Chim Acta 2015 Mar 3;442:1-5. Epub 2015 Jan 3.

Department of Surgical and Medical Therapeutics, University of Extremadura, Badajoz, Spain.

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http://dx.doi.org/10.1016/j.cca.2014.12.035DOI Listing
March 2015

Melanocortin-4 receptor gene variants are not associated with binge-eating behavior in nonobese patients with eating disorders.

Psychiatr Genet 2015 Feb;25(1):35-8

aDepartment of Medical and Surgical Therapeutics, Division of Pharmacology, Medical School, University of Extremadura bEating Disorders Unit, Health Service of Extremadura, Badajoz cService of Clinical Analyses, General University Hospital, Valencia, Spain dDepartment of Life Sciences, Research Center for Anthropology and Health (CIAS), University of Coimbra, Coimbra, Portugal.

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http://dx.doi.org/10.1097/YPG.0000000000000065DOI Listing
February 2015

BDNF genetic variability modulates psychopathological symptoms in patients with eating disorders.

Eur Child Adolesc Psychiatry 2014 Aug 29;23(8):669-79. Epub 2013 Nov 29.

Division of Clinical Pharmacology, Department of Medical and Surgical Therapeutics, Medical School, University of Extremadura, Avda. de Elvas s/n, 06005, Badajoz, Spain.

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http://dx.doi.org/10.1007/s00787-013-0495-6DOI Listing
August 2014

Hyperhaemolysis syndrome responsive to splenectomy in a patient with δβ-thalassaemia: a discussion on underlying mechanisms.

Blood Transfus 2014 Jan 15;12(1):127-9. Epub 2013 Nov 15.

Department of Surgical and Medical Therapeutics, Division of Pharmacology, University of Extremadura, Badajoz, Spain.

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http://dx.doi.org/10.2450/2013.0059-13DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3926715PMC
January 2014

Ethylenediaminetetraacetic acid-dependent pseudomacrocytosis.

J Clin Pathol 2013 Sep 30;66(9):811-4. Epub 2013 May 30.

Department of Pediatric Hematology, Materno Infantil Hospital, Badajoz, Spain.

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http://dx.doi.org/10.1136/jclinpath-2013-201545DOI Listing
September 2013

Influence of dopamine polymorphisms on the risk for anorexia nervosa and associated psychopathological features.

J Clin Psychopharmacol 2013 Aug;33(4):551-5

Department of Medical and Surgical Therapeutics, Division of Clinical Pharmacology, Medical School, University of Extremadura, Badajoz, Spain.

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http://dx.doi.org/10.1097/JCP.0b013e3182970469DOI Listing
August 2013

CYP2C8*3 polymorphism and donor age are associated with allograft dysfunction in kidney transplant recipients treated with calcineurin inhibitors.

J Clin Pharmacol 2013 Apr 20;53(4):427-34. Epub 2013 Feb 20.

Division of Pharmacology, Department of Medical and Surgical Therapeutics, Medical School, University of Extremadura, Badajoz, Spain.

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http://dx.doi.org/10.1002/jcph.15DOI Listing
April 2013

ABCB1 polymorphisms are associated with cyclosporine-induced nephrotoxicity and gingival hyperplasia in renal transplant recipients.

Eur J Clin Pharmacol 2013 Mar 11;69(3):385-93. Epub 2012 Aug 11.

Department of Surgical and Medical Therapeutics, Division of Pharmacology, Medical School, University of Extremadura, Av. Elvas s/n 06071, Badajoz, Spain.

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http://link.springer.com/10.1007/s00228-012-1355-x
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http://dx.doi.org/10.1007/s00228-012-1355-xDOI Listing
March 2013

Haplotypes in the 5'-untranslated region of the CYP1A2 gene are inversely associated with lung cancer risk but do not correlate with caffeine metabolism.

Environ Mol Mutagen 2013 Mar 9;54(2):124-32. Epub 2012 Nov 9.

Department of Medical & Surgical Therapeutics, Division of Pharmacology, Medical School, University of Extremadura, Badajoz, Spain.

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http://dx.doi.org/10.1002/em.21747DOI Listing
March 2013

Comparative cytochrome p450 in vitro inhibition by atypical antipsychotic drugs.

ISRN Pharmacol 2013 13;2013:792456. Epub 2013 Feb 13.

Department of Medical and Surgical Therapeutics, Division of Pharmacology, Medical School, University of Extremadura, Av. Elvas s/n, 06071 Badajoz, Spain.

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http://dx.doi.org/10.1155/2013/792456DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3586484PMC
March 2013

Central nervous system chemotoxicity during treatment of pediatric acute lymphoblastic leukemia/lymphoma.

Crit Rev Oncol Hematol 2012 Nov 11;84(2):274-86. Epub 2012 May 11.

Service of Pediatric Hematology, Materno Infantil Hospital, Badajoz, Spain.

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http://dx.doi.org/10.1016/j.critrevonc.2012.04.003DOI Listing
November 2012

Impact of genetic polymorphisms on chemotherapy toxicity in childhood acute lymphoblastic leukemia.

Front Genet 2012 22;3:249. Epub 2012 Nov 22.

Department of Medical and Surgical Therapeutics, Division of Pharmacology, Medical School, University of Extremadura Badajoz, Spain.

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http://dx.doi.org/10.3389/fgene.2012.00249DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3504364PMC
November 2012

Impact of genetic polymorphisms on tacrolimus pharmacokinetics and the clinical outcome of renal transplantation.

Transpl Int 2012 Apr 28;25(4):471-80. Epub 2012 Feb 28.

Department of Medical and Surgical Therapeutics, Medical School, University of Extremadura, Badajoz, Spain.

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http://dx.doi.org/10.1111/j.1432-2277.2012.01446.xDOI Listing
April 2012

N-Acetyltransferase-2 (NAT2) gene polymorphisms and enzyme activity in Serbs: unprecedented high prevalence of rapid acetylators in a White population.

J Clin Pharmacol 2011 Jul 27;51(7):994-1003. Epub 2010 Aug 27.

Division of Clinical Pharmacology, Department of Laboratory Medicine, Karolinska Institutet, Karolinska University Hospital, Huddinge, Stockholm, Sweden.

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http://dx.doi.org/10.1177/0091270010377630DOI Listing
July 2011

GST polymorphisms interact with dietary factors to modulate lung cancer risk: study in a high-incidence area.

Nutr Cancer 2010 ;62(6):750-8

Department of Pharmacology, Medical School, University of Extremadura, Badajoz, Spain.

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http://dx.doi.org/10.1080/01635581003605946DOI Listing
November 2010

Pharmacogenetic testing and therapeutic drug monitoring are complementary tools for optimal individualization of drug therapy.

Eur J Clin Pharmacol 2010 Aug 27;66(8):755-74. Epub 2010 Jun 27.

Department of Medical and Surgical Therapeutics, Division of Clinical Pharmacology, Medical School, University of Extremadura, 06071 Badajoz, Spain.

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http://dx.doi.org/10.1007/s00228-010-0857-7DOI Listing
August 2010

CYP2W1 variant alleles in Caucasians and association of the CYP2W1 G541A (Ala181Thr) polymorphism with increased colorectal cancer risk.

Pharmacogenomics 2010 Jul;11(7):919-25

Department of Pharmacology, School of Medicine, University of Extremadura, 06071 Badajoz, Spain.

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http://dx.doi.org/10.2217/pgs.10.66DOI Listing
July 2010

In vivo evaluation of CYP2A6 and xanthine oxidase enzyme activities in the Serbian population.

Eur J Clin Pharmacol 2010 Jun 13;66(6):571-8. Epub 2010 Feb 13.

Division of Clinical Pharmacology, Department of Laboratory Medicine, Karolinska University Hospital Huddinge, Karolinska Institutet, 14186, Stockholm, Sweden.

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http://dx.doi.org/10.1007/s00228-010-0785-6DOI Listing
June 2010

Polymorphisms in methotrexate pathways: what is clinically relevant, what is not, and what is promising.

Curr Drug Metab 2009 Jul 15;10(6):547-66. Epub 2009 Jul 15.

Department of Pharmacology, Medical School, University of Extremadura, Av. Elvas s/n 06071, Badajoz, Spain.

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July 2009

A common polymorphism in the bile acid receptor farnesoid X receptor is associated with decreased hepatic target gene expression.

Mol Endocrinol 2007 Aug 22;21(8):1769-80. Epub 2007 May 22.

Division of Clinical Pharmacology, Department of Medicine, The University of Western Ontario, London Health Sciences Centre, University Hospital, London, Ontario, Canada N6A 5A5.

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http://dx.doi.org/10.1210/me.2007-0025DOI Listing
August 2007

Effect of neurotransmitters on NADPH-cytochrome P450 reductase in vitro activity.

Drug Metab Lett 2007 Aug;1(3):172-5

Department of Pharmacology, Medical School, University of Extremadura, Badajoz, Spain.

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August 2007

Retinal toxic reactions following photopheresis.

Arch Dermatol 2007 May;143(5):622-5

Department of Hematology, University Hospital Infanta Cristina, Avda Elvas s/n, E-06080 Badajoz, Spain.

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http://dx.doi.org/10.1001/archderm.143.5.622DOI Listing
May 2007

The effect of CYP2J2, CYP3A4, CYP3A5 and the MDR1 polymorphisms and gender on the urinary excretion of the metabolites of the H-receptor antihistamine ebastine: a pilot study.

Br J Clin Pharmacol 2006 Aug;62(2):177-86

Department of Pharmacology and Psychiatry, Medical School and Clinical Pharmacology Unit, Infanta Cristina University Hospital, University of Extremadura, E-06071-Badajoz, Spain.

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http://dx.doi.org/10.1111/j.1365-2125.2006.02578.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1885094PMC
August 2006

Differences in CYP3A5*3 genotype distribution and combinations with other polymorphisms between Spaniards and Other Caucasian populations.

Ther Drug Monit 2005 Dec;27(6):819-21

Department of Pharmacology and Psychiatry, Medical School, and Clinical Pharmacology Unit, Infanta Cristina University Hospital, University of Extremadura, Badajoz, Spain.

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http://dx.doi.org/10.1097/01.ftd.0000186914.32038.a0DOI Listing
December 2005

Evaluation of a drug-drug interaction alert structure through the retrospective analysis of statins-macrolides co-prescriptions.

Basic Clin Pharmacol Toxicol 2005 Apr;96(4):289-94

Drug Surveillance Center of Extremadura, Department of Pharmacology and Psychiatry & Clinical Pharmacology Unit, Infanta Cristina University Hospital, Medical School, University of Extremadura, Badajoz, Spain.

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http://dx.doi.org/10.1111/j.1742-7843.2005.pto960403.xDOI Listing
April 2005

Polymorphisms in human organic anion-transporting polypeptide 1A2 (OATP1A2): implications for altered drug disposition and central nervous system drug entry.

J Biol Chem 2005 Mar 4;280(10):9610-7. Epub 2005 Jan 4.

Division of Clinical Pharmacology, Department of Medicine, Vanderbilt University, Nashville Tennessee 37232, USA.

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http://dx.doi.org/10.1074/jbc.M411092200DOI Listing
March 2005

Using a computerized drug prescription screening system to trace drug interactions in an outpatient setting.

Ann Pharmacother 2004 Jul-Aug;38(7-8):1301-6. Epub 2004 Jun 3.

Department of Pharmacology and Psychiatry, University of Extremadura Medical School, Badajoz, Spain.

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http://dx.doi.org/10.1345/aph.1D549DOI Listing
October 2004

Potential role of cerebral cytochrome P450 in clinical pharmacokinetics: modulation by endogenous compounds.

Clin Pharmacokinet 2004 ;43(11):693-706

Department of Pharmacology and Psychiatry, Medical School, University of Extremadura, Badajoz, Spain.

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http://dx.doi.org/10.2165/00003088-200443110-00001DOI Listing
September 2004

Early detection of drug interactions utilizing a computerized drug prescription handling system-focus on cerivastatin-gemfibrozil.

Eur J Clin Pharmacol 2004 Feb 21;59(12):917-21. Epub 2004 Jan 21.

Drug Surveillance Center of Extremadura, Department of Pharmacology, Medical School, University of Extremadura, Avenida de Elvas, 06071 Badajoz, Spain.

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http://dx.doi.org/10.1007/s00228-003-0711-2DOI Listing
February 2004

Applicability of an assay for routine monitoring of highly variable concentrations of olanzapine based on HPLC with mass spectrometric detection.

Clin Chem 2003 Dec;49(12):2088-91

Department of Pharmacology and Psychiatry, Extremadura University School of Medicine, E-06071 Badajoz, Spain.

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http://dx.doi.org/10.1373/clinchem.2003.022517DOI Listing
December 2003

Genotype-phenotype associations for common CYP3A4 and CYP3A5 variants in the basal and induced metabolism of midazolam in European- and African-American men and women.

Pharmacogenetics 2003 Oct;13(10):595-606

Division of Clinical Pharmacology, Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232-6602, USA.

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http://dx.doi.org/10.1097/01.fpc.0000054118.14659.48DOI Listing
October 2003

Role of the smoking-induced cytochrome P450 (CYP)1A2 and polymorphic CYP2D6 in steady-state concentration of olanzapine.

J Clin Psychopharmacol 2003 Apr;23(2):119-27

Department of Pharmacology and Psychiatry, Extremadura University School of Medicine, Badajoz, Spain.

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http://dx.doi.org/10.1097/00004714-200304000-00003DOI Listing
April 2003