Publications by authors named "Guillermina Lozano"

100Publications

p53 drives a transcriptional program that elicits a non-cell-autonomous response and alters cell state in vivo.

Proc Natl Acad Sci U S A 2020 09 8;117(38):23663-23673. Epub 2020 Sep 8.

Genetics and Epigenetics Program, The University of Texas MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences, Houston, TX 77030;

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September 2020

p53 tetramerization: at the center of the dominant-negative effect of mutant p53.

Genes Dev 2020 Sep;34(17-18):1128-1146

Genetics and Epigenetics Graduate Program, The University of Texas MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences, Houston, Texas 77030, USA.

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September 2020

Men1 maintains exocrine pancreas homeostasis in response to inflammation and oncogenic stress.

Proc Natl Acad Sci U S A 2020 03 10;117(12):6622-6629. Epub 2020 Mar 10.

Department of Genetics, University of Texas MD Anderson Cancer Center, Houston, TX 77030;

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March 2020

Identification of cancer sex-disparity in the functional integrity of p53 and its X chromosome network.

Nat Commun 2019 11 26;10(1):5385. Epub 2019 Nov 26.

Tumor Suppression Laboratory, Peter MacCallum Cancer Centre, 305 Grattan St, Melbourne, Victoria, 3000, Australia.

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November 2019

Transient enhancement of p53 activity protects from radiation-induced gastrointestinal toxicity.

Proc Natl Acad Sci U S A 2019 08 13;116(35):17429-17437. Epub 2019 Aug 13.

Department of Genetics, The University of Texas MD Anderson Cancer Center, Houston, TX 77030;

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August 2019

Restoring p53 in cancer: the promises and the challenges.

J Mol Cell Biol 2019 07;11(7):615-619

Department of Genetics, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.

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July 2019

Dicer1 Phosphomimetic Promotes Tumor Progression and Dissemination.

Cancer Res 2019 05 26;79(10):2662-2668. Epub 2019 Mar 26.

Department of Genetics, The University of Texas MD Anderson Cancer Center, Houston, Texas.

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May 2019

Constitutive Dicer1 phosphorylation accelerates metabolism and aging in vivo.

Proc Natl Acad Sci U S A 2019 01 28;116(3):960-969. Epub 2018 Dec 28.

Department of Genetics, The University of Texas MD Anderson Cancer Center, Houston, TX 77030;

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January 2019

One step at a time.

Mol Biol Cell 2018 11;29(22):2614-2615

Department of Genetics, University of Texas MD Anderson Cancer Center, Houston, TX 77030.

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November 2018

CRISPR/Cas9 can mediate high-efficiency off-target mutations in mice in vivo.

Cell Death Dis 2018 10 27;9(11):1099. Epub 2018 Oct 27.

Department of Genetics, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd., Houston, TX, 77030, USA.

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October 2018

Daxx Functions Are p53-Independent .

Mol Cancer Res 2018 10 14;16(10):1523-1529. Epub 2018 Jun 14.

Department of Genetics, The University of Texas MD Anderson Cancer Center, Houston, Texas.

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October 2018

A spontaneous model of spondyloarthropathies that develops bone loss and pathological bone formation: A process regulated by IL27RA-/- and mutant-p53.

PLoS One 2018 1;13(3):e0193485. Epub 2018 Mar 1.

Department of Pediatrics, The University of Texas MD Anderson Cancer Center, Houston, TX, United States of America.

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July 2018

SNPing away at mutant p53 activities.

Genes Dev 2018 02;32(3-4):195-196

Department of Genetics, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA.

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February 2018

Synergistic and additive effect of retinoic acid in circumventing resistance to p53 restoration.

Proc Natl Acad Sci U S A 2018 02 13;115(9):2198-2203. Epub 2018 Feb 13.

Genetics and Epigenetics Program, The University of Texas MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences, Houston, TX 77030;

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February 2018

Loss of digestive organ expansion factor ( reveals an essential role during murine embryonic development that is independent of p53.

Oncotarget 2017 Nov 26;8(61):103996-104006. Epub 2017 Oct 26.

Department of Genetics, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.

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November 2017

Spatio-Temporal Genomic Heterogeneity, Phylogeny, and Metastatic Evolution in Salivary Adenoid Cystic Carcinoma.

J Natl Cancer Inst 2017 10;109(10)

Affiliations of authors: Departments of Genetics and The Center for Genetics and Genomics (BL, XR, GL), Pathology (YM, AKEN), Head and Neck Surgery (MZ), Thoracic/Head and Neck Medical Oncology (JianjZ), and Genomic Medicine (JianjZ, JianhZ, PAF), The University of Texas MD Anderson Cancer Center, Houston, TX.

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October 2017

Mutant p53 partners in crime.

Cell Death Differ 2018 01 3;25(1):161-168. Epub 2017 Nov 3.

Department of Genetics, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.

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January 2018

Tumorigenesis promotes Mdm4-S overexpression.

Oncotarget 2017 Apr;8(16):25837-25847

Department of Genetics, M.D. Anderson Cancer Center, Houston, Texas, 77030, USA.

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April 2017

p53: Multiple Facets of a Rubik's Cube.

Annu Rev Cancer Biol 2017 Mar 17;1:185-201. Epub 2016 Oct 17.

Department of Genetics, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030.

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March 2017

TNBC invasion: downstream of STAT3.

Oncotarget 2017 03;8(13):20517-20518

Department of Genetics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

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March 2017

Mdm proteins: critical regulators of embry ogenesis and homeostasis.

J Mol Cell Biol 2017 Jan 15. Epub 2017 Jan 15.

Department of Genetics, The University of Texas M.D. Anderson Cancer Center, Houston, Texas 77030, USA

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January 2017

The Enigma of p53.

Cold Spring Harb Symp Quant Biol 2016 8;81:37-40. Epub 2016 Dec 8.

The University of Texas MD Anderson Cancer Center, Houston, Texas 77030.

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February 2018

The p53 inhibitor Mdm4 cooperates with multiple genetic lesions in tumourigenesis.

J Pathol 2017 03 6;241(4):501-510. Epub 2017 Jan 6.

Department of Genetics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

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March 2017

The Regulation of Cellular Functions by the p53 Protein: Cellular Senescence.

Cold Spring Harb Perspect Med 2017 Feb 1;7(2). Epub 2017 Feb 1.

Department of Biochemistry and Molecular Biology, Tulane School of Medicine, New Orleans, Louisiana 70112.

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February 2017

Attenuating the p53 Pathway in Human Cancers: Many Means to the Same End.

Cold Spring Harb Perspect Med 2016 08 1;6(8). Epub 2016 Aug 1.

Department of Genetics, The University of Texas M.D. Anderson Cancer Center, Houston, Texas 77030.

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August 2016

Lack of Immunomodulatory Interleukin-27 Enhances Oncogenic Properties of Mutant p53 In Vivo.

Clin Cancer Res 2016 08 15;22(15):3876-83. Epub 2016 Mar 15.

Department of Pediatrics, The University of Texas MD Anderson Cancer Center, Houston, Texas.

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August 2016

MDM2 Associates with Polycomb Repressor Complex 2 and Enhances Stemness-Promoting Chromatin Modifications Independent of p53.

Mol Cell 2016 Jan 31;61(1):68-83. Epub 2015 Dec 31.

Institute of Molecular Oncology, Göttingen Center for Molecular Biosciences (GZMB), University Medical Center Göttingen, Göttingen 37077, Germany. Electronic address:

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January 2016

Mutant p53 in concert with an interleukin-27 receptor alpha deficiency causes spontaneous liver inflammation, fibrosis, and steatosis in mice.

Hepatology 2016 Mar 21;63(3):1000-12. Epub 2016 Jan 21.

Department of Pediatrics, The University of Texas MD Anderson Cancer Center, Houston, TX.

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March 2016

Novel MYBL1 Gene Rearrangements with Recurrent MYBL1-NFIB Fusions in Salivary Adenoid Cystic Carcinomas Lacking t(6;9) Translocations.

Clin Cancer Res 2016 Feb 2;22(3):725-33. Epub 2015 Dec 2.

Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas. Department of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, Texas.

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February 2016

Mutant p53: Multiple Mechanisms Define Biologic Activity in Cancer.

Front Oncol 2015 11;5:249. Epub 2015 Nov 11.

Department of Genetics, The University of Texas MD Anderson Cancer Center , Houston, TX , USA.

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November 2015

p53 Activity Dominates That of p73 upon Mdm4 Loss in Development and Tumorigenesis.

Mol Cancer Res 2016 Jan 2;14(1):56-65. Epub 2015 Nov 2.

Department of Genetics, The University of Texas MD Anderson Cancer Center, Houston, Texas. The University of Texas Graduate School of Biomedical Sciences, Program in Genes and Development.

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January 2016

TRIM24 suppresses development of spontaneous hepatic lipid accumulation and hepatocellular carcinoma in mice.

J Hepatol 2015 Feb 2;62(2):371-9. Epub 2014 Oct 2.

Department of Biochemistry and Molecular Biology, UT MD Anderson Cancer Center, Houston, TX, USA; Center for Stem Cell and Developmental Biology, UT MD Anderson Cancer Center, Houston, TX, USA; Center for Cancer Epigenetics, UT MD Anderson Cancer Center, Houston, TX, USA; Graduate Program in Genes and Development, University of Texas Graduate School of Biomedical Sciences at Houston, Houston, TX, USA. Electronic address:

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February 2015

Limiting the power of p53 through the ubiquitin proteasome pathway.

Genes Dev 2014 Aug;28(16):1739-51

Department of Genetics, The University of Texas M.D. Anderson Cancer Center, Houston, Texas 77030, USA

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August 2014

Loss of the novel tumour suppressor and polarity gene Trim62 (Dear1) synergizes with oncogenic Ras in invasive lung cancer.

J Pathol 2014 Sep 16;234(1):108-19. Epub 2014 Jul 16.

Department of Genetics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA; Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

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September 2014

Inhibition of endothelial p53 improves metabolic abnormalities related to dietary obesity.

Cell Rep 2014 Jun 22;7(5):1691-1703. Epub 2014 May 22.

Department of Cardiovascular Biology and Medicine, Niigata University Graduate School of Medical and Dental Sciences, Niigata 951-8510, Japan; PRESTO, Japan Science and Technology Agency, Saitama 332-0012, Japan. Electronic address:

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June 2014

Tissue-specific and age-dependent effects of global Mdm2 loss.

J Pathol 2014 Aug 9;233(4):380-91. Epub 2014 Jun 9.

Department of Genetics, University of Texas MD Anderson Cancer Center, Houston, TX, USA.

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August 2014

USP15 stabilizes MDM2 to mediate cancer-cell survival and inhibit antitumor T cell responses.

Nat Immunol 2014 Jun 28;15(6):562-70. Epub 2014 Apr 28.

1] Department of Immunology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA. [2] The University of Texas Graduate School of Biomedical Sciences, Houston, Texas, USA.

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June 2014

Dissecting the p53-Mdm2 feedback loop in vivo: uncoupling the role in p53 stability and activity.

Oncotarget 2014 Mar;5(5):1149-56

Department of Genetics, M.D. Anderson Cancer Center, Houston, Texas.

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March 2014

Genome-wide association tests of inversions with application to psoriasis.

Hum Genet 2014 Aug 13;133(8):967-74. Epub 2014 Mar 13.

Biostatistics/Epidemiology/Research Design Core, Center for Clinical and Translational Sciences, The University of Texas Health Science Center at Houston, Houston, TX, 77030, USA,

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August 2014

The Mdm network and its regulation of p53 activities: a rheostat of cancer risk.

Hum Mutat 2014 Jun 6;35(6):728-37. Epub 2014 Mar 6.

Vanderbilt University Medical Center, Department of Pathology, Microbiology and Immunology, Nashville, Tennessee.

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June 2014

ASPP2 suppresses squamous cell carcinoma via RelA/p65-mediated repression of p63.

Proc Natl Acad Sci U S A 2013 Oct 14;110(44):17969-74. Epub 2013 Oct 14.

Ludwig Institute for Cancer Research, Nuffield Department of Clinical Medicine, and Weatherall Institute of Molecular Medicine, University of Oxford, Oxford OX3 7DQ, United Kingdom.

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October 2013

DEAR1 is a chromosome 1p35 tumor suppressor and master regulator of TGF-β-driven epithelial-mesenchymal transition.

Cancer Discov 2013 Oct 9;3(10):1172-89. Epub 2013 Jul 9.

Departments of 1Genetics and, 2Hematopathology, 3Pathology,4Translational Molecular Pathology, and 5Epidemiology, The University of Texas MD Anderson Cancer Center; 6The Human and Molecular Genetics Program, The University of Texas, Graduate School of Biomedical Science at Houston, Houston, Texas.

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October 2013

Molecular pathways: targeting Mdm2 and Mdm4 in cancer therapy.

Clin Cancer Res 2013 Jan 21;19(1):34-41. Epub 2012 Dec 21.

Department of Genetics, University of Texas M.D. Anderson Cancer Center, Houston, TX 77030, USA.

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January 2013

The Many Faces of MDM2 Binding Partners.

Genes Cancer 2012 Mar;3(3-4):226-39

Department of Genetics, University of Texas M.D. Anderson Cancer Center, Houston, TX, USA.

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March 2012

The p53 pathway in hematopoiesis: lessons from mouse models, implications for humans.

Blood 2012 Dec 27;120(26):5118-27. Epub 2012 Sep 27.

Department of Genetics, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.

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December 2012

The p53 family grows old.

Genes Dev 2012 Sep;26(18):1997-2000

Department of Biochemistry and Molecular Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA.

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September 2012

Che-ating death: CHE1/AATF protects from p53-mediated apoptosis.

EMBO J 2012 Oct 7;31(20):3951-3. Epub 2012 Sep 7.

Department of Genetics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

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October 2012

Developing genetically engineered mouse models to study tumor suppression.

Curr Protoc Mouse Biol 2012 Mar;2(1):9-24

Department of Genetics, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd. Houston, TX 77030.

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March 2012

Mutant p53 disrupts role of ShcA protein in balancing Smad protein-dependent and -independent signaling activity of transforming growth factor-β (TGF-β).

J Biol Chem 2011 Dec 28;286(51):44023-34. Epub 2011 Oct 28.

Department of Cellular and Structural Biology, Greehey Children's Cancer Research Institute, University of Texas Health Science Center, San Antonio, TX 78229-3900, USA.

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December 2011

Multiple stress signals activate mutant p53 in vivo.

Cancer Res 2011 Dec 7;71(23):7168-75. Epub 2011 Oct 7.

Department of Genetics, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA.

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December 2011

The ups and downs of p53 regulation in hematopoietic stem cells.

Cell Cycle 2011 Oct 1;10(19):3257-62. Epub 2011 Oct 1.

Department of Genetics, University of Texas MD Anderson Cancer Center, Houston, TX, USA.

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October 2011

Heterodimerization of Mdm2 and Mdm4 is critical for regulating p53 activity during embryogenesis but dispensable for p53 and Mdm2 stability.

Proc Natl Acad Sci U S A 2011 Jul 5;108(29):11995-2000. Epub 2011 Jul 5.

Department of Genetics, University of Texas M. D. Anderson Cancer Center, Houston, TX 77030, USA.

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July 2011

Differential gene expression profiling of aggressive and nonaggressive follicular carcinomas.

Hum Pathol 2011 Sep 21;42(9):1213-20. Epub 2011 Mar 21.

Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.

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September 2011

Joint effects of germ-line TP53 mutation, MDM2 SNP309, and gender on cancer risk in family studies of Li-Fraumeni syndrome.

Hum Genet 2011 Jun 9;129(6):663-73. Epub 2011 Feb 9.

Department of Epidemiology, Unit 1340, The University of Texas M. D. Anderson Cancer Center, Houston, TX 77030, USA.

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June 2011

Mdm2 is required for survival of hematopoietic stem cells/progenitors via dampening of ROS-induced p53 activity.

Cell Stem Cell 2010 Nov;7(5):606-17

Program in Genes and Development of The Graduate School of Biomedical Sciences, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.

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November 2010

Regulation of tissue- and stimulus-specific cell fate decisions by p53 in vivo.

J Pathol 2011 Jan 18;223(2):127-36. Epub 2010 Oct 18.

Department of Genetics, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.

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January 2011

Mesenchymal Stem Cells and the Origin of Ewing's Sarcoma.

Sarcoma 2011 5;2011. Epub 2010 Oct 5.

Department of Orthopaedic Oncology (Unit 1448), University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA.

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July 2011

Building p53.

Genes Dev 2010 Oct;24(20):2229-32

Department of Dermatology/Stem Cell Biology, University of Colorado at Denver, Aurora, Colorado 80045, USA.

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October 2010

p53 status in stromal fibroblasts modulates tumor growth in an SDF1-dependent manner.

Cancer Res 2010 Dec 15;70(23):9650-8. Epub 2010 Oct 15.

Department of Biological Regulation, The Weizmann Institute, Rehovot, Israel.

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December 2010

You can win by losing: p53 mutations in rhabdomyosarcomas.

J Pathol 2010 Oct;222(2):124-8

Department of Genetics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

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October 2010

Spontaneous tumorigenesis in mice overexpressing the p53-negative regulator Mdm4.

Cancer Res 2010 Sep 24;70(18):7148-54. Epub 2010 Aug 24.

Departments of Genetics and Veterinary Medicine and Surgery, The University of Texas M.D. Anderson Cancer Center Houston, TX 77030, USA.

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September 2010

Mouse models of p53 functions.

Cold Spring Harb Perspect Biol 2010 Apr 9;2(4):a001115. Epub 2009 Dec 9.

Department of Genetics, The University of Texas M.D. Anderson Cancer Center, Houston, 77030, USA.

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April 2010

E2F3 is a mediator of DNA damage-induced apoptosis.

Mol Cell Biol 2010 Jan 16;30(2):524-36. Epub 2009 Nov 16.

Department of Biochemistry, University of Mississippi Medical Center, 2500 North State Street, Jackson, MS 39216, USA.

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January 2010

20 years studying p53 functions in genetically engineered mice.

Nat Rev Cancer 2009 11 24;9(11):831-41. Epub 2009 Sep 24.

Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas 77030, USA.

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November 2009

Targeted mutation of p53 and Rb in mesenchymal cells of the limb bud produces sarcomas in mice.

Carcinogenesis 2009 Oct 27;30(10):1789-95. Epub 2009 Jul 27.

Department of Orthopaedic Oncology, The University of Texas M.D. Anderson Cancer Center, Houston, TX 77230-1402, USA.

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October 2009

Expression signatures of metastatic capacity in a genetic mouse model of lung adenocarcinoma.

PLoS One 2009 30;4(4):e5401. Epub 2009 Apr 30.

Department of Thoracic/Head and Neck Medical Oncology, The University of Texas, MD Anderson Cancer Center, Houston, Texas, United States of America.

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August 2009

Mdm4 loss in the intestinal epithelium leads to compartmentalized cell death but no tissue abnormalities.

Differentiation 2009 Jun 15;77(5):442-9. Epub 2009 Apr 15.

Department of Genetics, Program in Genes and Development and Graduate School of Biomedical Sciences, University of Texas, M.D. Anderson Cancer Center, 1515 Holcombe Blvd., Houston, TX 77030, USA.

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June 2009

p53 and MDM2: antagonists or partners in crime?

Cancer Cell 2009 Mar;15(3):161-2

Department of Pathology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA.

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March 2009

EWS-FLI1 induces developmental abnormalities and accelerates sarcoma formation in a transgenic mouse model.

Cancer Res 2008 Nov;68(21):8968-75

Department of Orthopaedic Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA.

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November 2008

Mdm2 and Mdm4 loss regulates distinct p53 activities.

Mol Cancer Res 2008 Jun;6(6):947-54

Department of Cancer Genetics, The University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030-4095, USA.

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June 2008

The inherent instability of mutant p53 is alleviated by Mdm2 or p16INK4a loss.

Genes Dev 2008 May;22(10):1337-44

Department of Cancer Genetics, The University of Texas M.D. Anderson Cancer Center, Houston, Texas 77030, USA.

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May 2008

High levels of the p53 inhibitor MDM4 in head and neck squamous carcinomas.

Hum Pathol 2007 Oct 24;38(10):1553-62. Epub 2007 Jul 24.

Department of Cancer Genetics, University of Texas M.D. Anderson Cancer Center, Houston, TX 77030, USA.

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October 2007

Mammary tumor modifiers in BALB/cJ mice heterozygous for p53.

Mamm Genome 2007 May 8;18(5):300-9. Epub 2007 Jun 8.

The University of Texas Graduate School of Biomedical Sciences and the Department of Cancer Genetics, The University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030, USA.

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May 2007

Loss of Mdm4 results in p53-dependent dilated cardiomyopathy.

Circulation 2007 Jun 28;115(23):2925-30. Epub 2007 May 28.

Department of Cancer Genetics, The University of Texas, M.D. Anderson Cancer Center, Houston, TX 77030, USA.

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June 2007

Haploinsufficiency of Mdm2 and Mdm4 in tumorigenesis and development.

Mol Cell Biol 2007 Aug 25;27(15):5479-85. Epub 2007 May 25.

Department of Cancer Genetics, Box 1010, The University of Texas M. D. Anderson Cancer Center, Baylor College of Medicine, 1515 Holcombe Boulevard, Houston, TX 77030, USA.

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August 2007