Publications by authors named "Guillermina Asins"

19Publications

(-)-UB006: A new fatty acid synthase inhibitor and cytotoxic agent without anorexic side effects.

Eur J Med Chem 2017 May 12;131:207-221. Epub 2017 Mar 12.

Department of Biochemistry and Physiology, Facultat de Farmàcia i Ciències de l'A limentació and Institut de Biomedicina de la Universitat de Barcelona (IBUB), Universitat de Barcelona, E-08028 Barcelona, Spain; Institut de Biomedicina de la Universitat de Barcelona (IBUB), Spain; Centro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y la Nutrición (CIBEROBN), Instituto de Salud Carlos III, E-28029 Madrid, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.ejmech.2017.03.012DOI Listing
May 2017

Long-term increased carnitine palmitoyltransferase 1A expression in ventromedial hypotalamus causes hyperphagia and alters the hypothalamic lipidomic profile.

PLoS One 2014 12;9(5):e97195. Epub 2014 May 12.

Department of Biochemistry and Molecular Biology, Facultat de Farmàcia, Universitat de Barcelona and Institut de Biomedicina de la Universitat de Barcelona (IBUB) and CIBER Fisiopatología de la Obesidad y la Nutrición (CIBERobn), Instituto de Salud Carlos III, Barcelona, Spain.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0097195PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4018328PMC
June 2015

Differential pharmacologic properties of the two C75 enantiomers: (+)-C75 is a strong anorectic drug; (-)-C75 has antitumor activity.

Chirality 2013 May;25(5):281-7

Department of Biochemistry and Molecular Biology, Facultat de Farmàcia, Universitat de Barcelona, E-08028 Barcelona, Spain.

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http://doi.wiley.com/10.1002/chir.22139
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http://dx.doi.org/10.1002/chir.22139DOI Listing
May 2013

Molecular therapy for obesity and diabetes based on a long-term increase in hepatic fatty-acid oxidation.

Hepatology 2011 Mar 11;53(3):821-32. Epub 2011 Feb 11.

Department of Biochemistry and Molecular Biology, Institut de Biomedicina de la Universitat de Barcelona (IBUB), Barcelona, Spain.

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http://dx.doi.org/10.1002/hep.24140DOI Listing
March 2011

Novel role of FATP1 in mitochondrial fatty acid oxidation in skeletal muscle cells.

J Lipid Res 2009 Sep 9;50(9):1789-99. Epub 2009 May 9.

Departments of Biochemistry and Molecular Biology, School of Pharmacy, University of Barcelona, Barcelona, Spain.

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http://dx.doi.org/10.1194/jlr.M800535-JLR200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2724792PMC
September 2009

CPT1c is localized in endoplasmic reticulum of neurons and has carnitine palmitoyltransferase activity.

J Biol Chem 2008 Mar 11;283(11):6878-85. Epub 2008 Jan 11.

Molecular and Cellular Unit, School of Health Sciences, Universitat Internacional de Catalunya, Josep Trueta s/n, Sant Cugat del Vallés, Barcelona 08195, Spain.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M707965200
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http://dx.doi.org/10.1074/jbc.M707965200DOI Listing
March 2008

Definition by functional and structural analysis of two malonyl-CoA sites in carnitine palmitoyltransferase 1A.

J Biol Chem 2007 Jun 23;282(25):18212-24. Epub 2007 Apr 23.

Centro de Biología Molecular Severo Ochoa (Consejo Superior de Investigaciones Científicas-Universidad Autónoma de Madrid), Cantoblanco, E-28049 Madrid, Spain.

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http://dx.doi.org/10.1074/jbc.M700885200DOI Listing
June 2007

CPT I overexpression protects L6E9 muscle cells from fatty acid-induced insulin resistance.

Am J Physiol Endocrinol Metab 2007 Mar 24;292(3):E677-86. Epub 2006 Oct 24.

Department of Biochemistry and Molecular Biology, School of Pharmacy, University of Barcelona, Diagonal 643, E-08028, Spain.

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http://dx.doi.org/10.1152/ajpendo.00360.2006DOI Listing
March 2007

Mutagenesis of specific amino acids converts carnitine acetyltransferase into carnitine palmitoyltransferase.

Biochemistry 2006 May;45(19):6133-41

Department of Biochemistry and Molecular Biology, School of Pharmacy, University of Barcelona, E-08028 Spain.

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http://dx.doi.org/10.1021/bi0602664DOI Listing
May 2006

Novel effect of C75 on carnitine palmitoyltransferase I activity and palmitate oxidation.

Biochemistry 2006 Apr;45(14):4339-50

Department of Biochemistry and Molecular Biology, School of Pharmacy, University of Barcelona, E-08028 Barcelona, Spain.

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http://dx.doi.org/10.1021/bi052186qDOI Listing
April 2006

Alteration of the malonyl-CoA/carnitine palmitoyltransferase I interaction in the beta-cell impairs glucose-induced insulin secretion.

Diabetes 2005 Feb;54(2):462-71

Department of Biochemistry and Molecular Biology, School of Pharmacy, University of Barcelona, Diagonal 643, E-08028 Barcelona, Spain.

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http://dx.doi.org/10.2337/diabetes.54.2.462DOI Listing
February 2005

Redesign of carnitine acetyltransferase specificity by protein engineering.

J Biol Chem 2004 Aug 21;279(32):33899-908. Epub 2004 May 21.

Department of Biochemistry and Molecular Biology, School of Pharmacy, University of Barcelona, Diagonal 643, E-08028 Barcelona, Spain.

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http://dx.doi.org/10.1074/jbc.M402685200DOI Listing
August 2004

Structural model of carnitine palmitoyltransferase I based on the carnitine acetyltransferase crystal.

Biochem J 2004 May;379(Pt 3):777-84

Department of Biochemistry and Molecular Biology, School of Pharmacy, University of Barcelona, E-08028 Barcelona, Spain.

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http://dx.doi.org/10.1042/BJ20031373DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1224103PMC
May 2004

Structural model of a malonyl-CoA-binding site of carnitine octanoyltransferase and carnitine palmitoyltransferase I: mutational analysis of a malonyl-CoA affinity domain.

J Biol Chem 2002 Mar 14;277(13):11473-80. Epub 2002 Jan 14.

Department of Biochemistry and Molecular Biology, School of Pharmacy, University of Barcelona, E-08028 Barcelona, Spain.

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http://dx.doi.org/10.1074/jbc.M111628200DOI Listing
March 2002