Publications by authors named "Guillaume Bernadat"

38Publications

A thorough evaluation of matrix-free laser desorption ionization on structurally diverse alkaloids and their direct detection in plant extracts.

Anal Bioanal Chem 2020 Nov 26;412(27):7405-7416. Epub 2020 Aug 26.

SONAS EA921, Université of Angers, SFR QUASAV, Faculty of Health Sciences, Department of Pharmacy, 16 Bd Daviers, 49045, Angers, France.

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http://dx.doi.org/10.1007/s00216-020-02872-6DOI Listing
November 2020

Phenylpropane as an Alternative Dearomatizing Unit of Indoles: Discovery of Inaequalisines A and B Using Substructure-Informed Molecular Networking.

Org Lett 2020 Aug 20;22(15):6077-6081. Epub 2020 Jul 20.

Équipe "Chimie des Substances Naturelles" Université Paris-Saclay, CNRS, BioCIS, 5 rue J.-B. Clément, 92290 Châtenay-Malabry, France.

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http://dx.doi.org/10.1021/acs.orglett.0c02153DOI Listing
August 2020

Synthesis and Anticancer Properties of Oxazepines Related to Azaisoerianin and IsoCoQuines.

ChemMedChem 2020 Jun 2. Epub 2020 Jun 2.

Université Paris-Saclay, CNRS, BioCIS, 92290, Châtenay-Malabry, France.

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http://dx.doi.org/10.1002/cmdc.202000197DOI Listing
June 2020

Enantioselective Redox-Divergent Chiral Phosphoric Acid Catalyzed Quinone Diels-Alder Reactions.

Angew Chem Int Ed Engl 2020 05 18;59(22):8491-8496. Epub 2020 Mar 18.

Institut de Chimie des Substances Naturelles CNRS, Univ. Paris-Saclay, 1 Avenue de la Terrasse, 91198, Gif-sur-Yvette Cedex, France.

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http://dx.doi.org/10.1002/anie.202000838DOI Listing
May 2020

Molecular Networking Reveals Serpentinine-Related Bisindole Alkaloids from , a Previously Well-Investigated Species.

J Nat Prod 2020 04 24;83(4):1207-1216. Epub 2020 Feb 24.

Équipe "Pharmacognosie - Chimie des Substances Naturelles", Université Paris-Saclay, CNRS, BioCIS, 92290, Châtenay-Malabry, France.

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http://dx.doi.org/10.1021/acs.jnatprod.9b01247DOI Listing
April 2020

Introducing sequential aza-amino acids units induces repeated β-turns and helical conformations in peptides.

Org Biomol Chem 2020 May 24;18(18):3452-3458. Epub 2020 Feb 24.

Université Paris-Saclay, CNRS, BioCIS, 92290 Châtenay-Malabry, France.

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http://dx.doi.org/10.1039/c9ob02654aDOI Listing
May 2020

Nervisides I-J: Unconventional Side-Chain-Bearing Cycloartane Glycosides from .

Molecules 2019 Jul 17;24(14). Epub 2019 Jul 17.

Équipe "Pharmacognosie-Chimie des Substances Naturelles", BioCIS, Univ. Paris-Sud, CNRS, Université Paris-Saclay, 5 Rue Jean-Baptiste Clément, 92290 Châtenay-Malabry, France.

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http://dx.doi.org/10.3390/molecules24142599DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6681409PMC
July 2019

Synthesis of 3,5-Disubstituted 1,2-Dioxolanes through the Use of Acetoxy Peroxyacetals.

Org Lett 2019 06 11;21(12):4729-4733. Epub 2019 Jun 11.

BioCIS , Université Paris-Sud, CNRS, Université Paris-Saclay , Chatenay-Malabry 92290 , France.

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http://dx.doi.org/10.1021/acs.orglett.9b01616DOI Listing
June 2019

Chiral phosphoric acid-catalyzed enantioselective construction of structurally diverse benzothiazolopyrimidines.

Chem Sci 2019 Apr 7;10(13):3765-3769. Epub 2019 Feb 7.

Institut de Chimie des Substances Naturelles , CNRS UPR 2301 , Université Paris-Sud , Université Paris-Saclay , 1, Avenue de la Terrasse, 91198 Gif-sur-Yvette Cedex , France . Email:

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http://xlink.rsc.org/?DOI=C8SC05581E
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http://dx.doi.org/10.1039/c8sc05581eDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6461124PMC
April 2019

DP4-Assisted Structure Elucidation of Isodemethylchodatin, a New Norlichexanthone Derivative Meager in H-Atoms, from the Lichen .

Molecules 2019 Apr 18;24(8). Epub 2019 Apr 18.

Équipe "Pharmacognosie⁻Chimie des Substances Naturelles", BioCIS, Univ. Paris-Sud, CNRS, Université Paris-Saclay, 5 Rue Jean-Baptiste Clément, 92290 Châtenay-Malabry, France.

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https://www.mdpi.com/1420-3049/24/8/1527
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http://dx.doi.org/10.3390/molecules24081527DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6515090PMC
April 2019

Theionbrunonines A and B: Dimeric Vobasine Alkaloids Tethered by a Thioether Bridge from Mostuea brunonis.

Org Lett 2018 10 10;20(20):6596-6600. Epub 2018 Oct 10.

Équipe "Pharmacognosie-Chimie des Substances Naturelles" BioCIS , Université Paris-Sud, CNRS, Université Paris-Saclay , 5 rue J.-B. Clément , 92290 Châtenay-Malabry , France.

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http://dx.doi.org/10.1021/acs.orglett.8b02961DOI Listing
October 2018

Enantioselective Brønsted Acid Catalysis as a Tool for the Synthesis of Natural Products and Pharmaceuticals.

Chemistry 2018 Mar 4;24(16):3925-3943. Epub 2017 Dec 4.

Institut de Chimie des Substances Naturelles, CNRS UPR 2301, Université Paris-Sud, Université Paris-Saclay, 1 av. de la Terrasse, 91198, Gif-sur-Yvette Cedex, France.

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http://doi.wiley.com/10.1002/chem.201703556
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http://dx.doi.org/10.1002/chem.201703556DOI Listing
March 2018

Unified biomimetic assembly of voacalgine A and bipleiophylline via divergent oxidative couplings.

Nat Chem 2017 02 27;9(8):793-798. Epub 2017 Feb 27.

Institut de Chimie Moléculaire et des Matériaux d'Orsay (ICMMO), Université Paris-Sud, Université Paris-Saclay, CNRS, UMR 8182, 91405 Orsay Cedex, France.

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http://dx.doi.org/10.1038/nchem.2735DOI Listing
February 2017

Revisiting Previously Investigated Plants: A Molecular Networking-Based Study of Geissospermum laeve.

J Nat Prod 2017 04 10;80(4):1007-1014. Epub 2017 Mar 10.

Équipe "Pharmacognosie-Chimie des Substances Naturelles" BioCIS, Univ. Paris-Sud, CNRS, Université Paris-Saclay , 5 Rue J.-B. Clément, 92290 Châtenay-Malabry, France.

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http://dx.doi.org/10.1021/acs.jnatprod.6b01013DOI Listing
April 2017

Design, synthesis and anticancer properties of IsoCombretaQuinolines as potent tubulin assembly inhibitors.

Eur J Med Chem 2017 Feb 9;127:1025-1034. Epub 2016 Nov 9.

BioCIS, Univ. Paris-Sud, CNRS, Université Paris-Saclay, 92290, Châtenay-Malabry, France. Electronic address:

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http://dx.doi.org/10.1016/j.ejmech.2016.11.012DOI Listing
February 2017

Enantioselective Three-Component Amination of Enecarbamates Enables the Synthesis of Structurally Complex Small Molecules.

J Org Chem 2017 02 25;82(3):1775-1789. Epub 2017 Jan 25.

Institut de Chimie des Substances Naturelles, CNRS UPR 2301, Université Paris-Sud, Université Paris-Saclay , 1 av. de la Terrasse, Gif-sur-Yvette 91198 Cedex, France.

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http://dx.doi.org/10.1021/acs.joc.6b03093DOI Listing
February 2017

Interaction of chemokine receptor CXCR4 in monomeric and dimeric state with its endogenous ligand CXCL12: coarse-grained simulations identify differences.

J Biomol Struct Dyn 2017 Feb 11;35(2):399-412. Epub 2016 Jul 11.

c BioCIS - UMR 8076, Université Paris-Sud, CNRS, Université Paris-Saclay , Châtenay-Malabry , France.

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http://dx.doi.org/10.1080/07391102.2016.1145142DOI Listing
February 2017

Comparative study of structural models of Leishmania donovani and human GDP-mannose pyrophosphorylases.

Eur J Med Chem 2016 Jan 30;107:109-18. Epub 2015 Oct 30.

BioCIS, Université Paris-Sud, CNRS, Université Paris-Saclay, 5 rue Jean-Baptiste Clément, 92296 Châtenay-Malabry, France. Electronic address:

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http://dx.doi.org/10.1016/j.ejmech.2015.10.037DOI Listing
January 2016

Diversity-oriented synthesis of fused thioglycosyl benzo[e][1,4]oxathiepin-5-ones and benzo[f][1,4]thiazepin-5(2H)-ones by a sequence of palladium-catalyzed glycosyl thiol arylation and deprotection-lactonization reactions.

Org Biomol Chem 2015 Nov 15;13(44):10904-16. Epub 2015 Sep 15.

Univ. Paris-Sud, CNRS, BioCIS-UMR 8076, Laboratoire de Chimie Thérapeutique, Equipe Labellisée Ligue Contre Le Cancer, LabEx LERMIT, Faculté de Pharmacie, 5 rue J.-B. Clément, Châtenay-Malabry, F-92296, France.

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http://dx.doi.org/10.1039/c5ob01603gDOI Listing
November 2015

Regio-, Diastereo-, and Enantioselective Nitroso-Diels-Alder Reaction of 1,3-Diene-1-carbamates Catalyzed by Chiral Phosphoric Acids.

J Am Chem Soc 2015 Sep 11;137(37):11950-3. Epub 2015 Sep 11.

Institut de Chimie des Substances Naturelles CNRS, Université Paris-Sud , 1 Avenue de la Terrasse, 91198 Gif-sur-Yvette Cedex, France.

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http://dx.doi.org/10.1021/jacs.5b08515DOI Listing
September 2015

IsoCombretaQuinazolines: Potent Cytotoxic Agents with Antitubulin Activity.

ChemMedChem 2015 Aug 15;10(8):1392-402. Epub 2015 Jun 15.

Univ. Paris-Sud, CNRS, BioCIS-UMR 8076, Laboratoire de Chimie Thérapeutique, Equipe Labellisée Ligue Contre le Cancer, LabEx LERMIT, Faculté de Pharmacie, 5 rue J.-B. Clément, Châtenay-Malabry, 92296 (France).

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http://dx.doi.org/10.1002/cmdc.201500069DOI Listing
August 2015

Synthesis of a 3-(α-styryl)benzo[b]-thiophene library via bromocyclization of alkynes and palladium-catalyzed to sylhydrazones cross-couplings: evaluation as antitubulin agents.

ACS Comb Sci 2014 Dec 25;16(12):702-10. Epub 2014 Sep 25.

Univ Paris Sud, CNRS, BioCIS-UMR 8076 , Laboratoire de Chimie Thérapeutique, Equipe Labellisée Ligue Contre le Cancer, LabEx LERMIT, Faculté de Pharmacie, 5 rue J.-B. Clément, Châtenay-Malabry, F-92296, France.

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http://dx.doi.org/10.1021/co500115bDOI Listing
December 2014

A unified bioinspired "aplysinopsin cascade": total synthesis of (±)-tubastrindole B and related biosynthetic congeners.

Org Lett 2014 Oct 15;16(19):4980-3. Epub 2014 Sep 15.

Laboratoire de pharmacognosie, Université Paris-Sud , UMR CNRS 8076 BioCIS, LabEx LERMIT, Faculté de Pharmacie, 5, rue Jean-Baptiste Clément, 92296 Châtenay-Malabry, France.

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http://dx.doi.org/10.1021/ol502177mDOI Listing
October 2014

Spontaneous biomimetic formation of (±)-dictazole B under irradiation with artificial sunlight.

Angew Chem Int Ed Engl 2014 Jun 9;53(25):6419-24. Epub 2014 May 9.

Laboratoire de Pharmacognosie associé au CNRS, UMR 8076 BioCIS, LabEx LERMIT, Université Paris-Sud, 5, rue Jean-Baptiste Clément, 92296 Châtenay-Malabry (France) http://www.biocis.u-psud.fr.

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http://dx.doi.org/10.1002/anie.201403454DOI Listing
June 2014

Discovery of azaisoerianin derivatives as potential antitumors agents.

Eur J Med Chem 2014 May 13;78:178-89. Epub 2014 Mar 13.

Univ Paris-Sud, CNRS, BioCIS-UMR 8076, Laboratoire de Chimie Thérapeutique, LabEx LERMIT, Equipe Labellisée Ligue Contre le Cancer, Faculté de Pharmacie, 5 rue J.-B. Clément, Châtenay-Malabry F-92296, France. Electronic address:

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http://dx.doi.org/10.1016/j.ejmech.2014.03.032DOI Listing
May 2014

A one-pot synthesis of 3-trifluoromethyl-2-isoxazolines from trifluoromethyl aldoxime.

Beilstein J Org Chem 2013 7;9:2387-94. Epub 2013 Nov 7.

BioCIS CNRS, Faculté de Pharmacie, Labex-LERMIT, Univ Paris Sud, 5 rue J. B. Clément, 92290 Châtenay-Malabry, France.

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http://dx.doi.org/10.3762/bjoc.9.275DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3869255PMC
December 2013

α- and β-hydrazino acid-based pseudopeptides inhibit the chymotrypsin-like activity of the eukaryotic 20S proteasome.

Eur J Med Chem 2013 17;70:505-24. Epub 2013 Oct 17.

Molécules Fluorées et Chimie Médicinale, BioCIS UMR-CNRS 8076, LabEx LERMIT, Université Paris-Sud 11, Faculté de Pharmacie, 5 rue Jean-Baptiste Clément, 92296 Châtenay-Malabry Cedex, France.

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http://dx.doi.org/10.1016/j.ejmech.2013.09.059DOI Listing
September 2014

Carbonic anhydrase binding site parameterization in OPLS-AA force field.

Bioorg Med Chem 2013 Mar 2;21(6):1427-30. Epub 2012 Nov 2.

Institut de Chimie des Substances Naturelles, CNRS UPR 2301, Labex LERMIT, Centre de Recherche de Gif, 1 Avenue de la Terrasse, F-91198 Gif-sur-Yvette, France.

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http://dx.doi.org/10.1016/j.bmc.2012.10.040DOI Listing
March 2013

Non-covalent proteasome inhibitors.

Curr Pharm Des 2013 ;19(22):4115-30

Molécules Fluorées et Chimie Médicinale, BioCIS UMR-CNRS 8076, LabEx LERMIT, Universite Paris- Sud, Faculté de Pharmacie, 5 rue Jean-Baptiste Clément, 92296, Châtenay- Malabry Cedex, France.

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http://dx.doi.org/10.2174/1381612811319220016DOI Listing
April 2014

Synthesis, biological evaluation, and structure-activity relationships of tri- and tetrasubstituted olefins related to isocombretastatin A-4 as new tubulin inhibitors.

Org Biomol Chem 2013 Jan 9;11(3):430-42. Epub 2012 Oct 9.

Université Paris-Sud, CNRS, BioCIS UMR 8076, LabEx LERMIT, Laboratoire de Chimie Thérapeutique, Faculté de Pharmacie, 5 rue J-B Clément, Châtenay-Malabry, F-92296, France.

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http://dx.doi.org/10.1039/c2ob26253cDOI Listing
January 2013

Carbonylhydrazide-based molecular tongs inhibit wild-type and mutated HIV-1 protease dimerization.

J Med Chem 2012 Aug 31;55(15):6762-75. Epub 2012 Jul 31.

UMR-CNRS 8076, Molécules Fluorées et Chimie Médicinale, LabEx LERMIT, Faculté de Pharmacie, Université Paris-Sud 11, 5 rue J. B. Clément, 92296 Châtenay-Malabry Cedex, France.

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http://dx.doi.org/10.1021/jm300181jDOI Listing
August 2012

Synthetic studies on (-)-lemonomycin: an efficient asymmetric synthesis of lemonomycinone amide.

J Org Chem 2009 Mar;74(5):2046-52

Institut de Chimie des Substances Naturelles, CNRS, 91198 Gif-sur-Yvette Cedex, France.

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http://dx.doi.org/10.1021/jo8027449DOI Listing
March 2009