Publications by authors named "Guido Silvestri"

100Publications

Innate, non-cytolytic CD8+ T cell-mediated suppression of HIV replication by MHC-independent inhibition of virus transcription.

PLoS Pathog 2020 09 17;16(9):e1008821. Epub 2020 Sep 17.

Division of Microbiology and Immunology, Yerkes National Primate Research Center, and Emory Vaccine Center Emory University, Atlanta, Georgia, United States of America.

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http://dx.doi.org/10.1371/journal.ppat.1008821DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7523993PMC
September 2020

Lower nasopharyngeal viral load during the latest phase of COVID-19 pandemic in a Northern Italy University Hospital.

Clin Chem Lab Med 2020 08 29;58(9):1573-1577. Epub 2020 Jun 29.

Laboratory of Medical Microbiology and Virology, University "Vita-Salute" San Raffaele, Via Olgettina 58, 20132 Milan, Italy.

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http://dx.doi.org/10.1515/cclm-2020-0815DOI Listing
August 2020

Virologic and Immunologic Features of Simian Immunodeficiency Virus Control Post-ART Interruption in Rhesus Macaques.

J Virol 2020 Jul 1;94(14). Epub 2020 Jul 1.

Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA

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http://dx.doi.org/10.1128/JVI.00338-20DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7343203PMC
July 2020

Rapid Germinal Center and Antibody Responses in Non-human Primates after a Single Nanoparticle Vaccine Immunization.

Cell Rep 2019 11;29(7):1756-1766.e8

Division of Vaccine Discovery, La Jolla Institute for Immunology (LJI), La Jolla, CA 92037, USA; Center for HIV/AIDS Vaccine Development, The Scripps Research Institute, La Jolla, CA 92037, USA; Division of Infectious Diseases and Global Public Health, Department of Medicine, University of California San Diego, San Diego, CA 92103, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2019.10.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6905039PMC
November 2019

CD8+ lymphocyte control of SIV infection during antiretroviral therapy.

PLoS Pathog 2018 10 11;14(10):e1007350. Epub 2018 Oct 11.

Theoretical Biology and Biophysics (T-6), Los Alamos National Laboratory, Los Alamos, NM, United States of America.

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http://dx.plos.org/10.1371/journal.ppat.1007350
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http://dx.doi.org/10.1371/journal.ppat.1007350DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6199003PMC
October 2018

Longing for HIV protection.

Nat Microbiol 2018 Jun;3(6):648-649

Emory Vaccine Center and Yerkes National Primate Research Center, Emory University, Atlanta, GA, USA.

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http://dx.doi.org/10.1038/s41564-018-0169-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6391887PMC
June 2018

Loss of CXCR6 coreceptor usage characterizes pathogenic lentiviruses.

PLoS Pathog 2018 04 16;14(4):e1007003. Epub 2018 Apr 16.

Departments of Medicine and Microbiology, University of Pennsylvania School of Medicine, Philadelphia, PA, United States of America.

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http://dx.doi.org/10.1371/journal.ppat.1007003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5919676PMC
April 2018

Mechanisms of CD8 T cell-mediated suppression of HIV/SIV replication.

Eur J Immunol 2018 06 26;48(6):898-914. Epub 2018 Mar 26.

Emory Vaccine Center and Yerkes National Primate Research Center, Emory University, Atlanta, GA, 30329, USA.

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http://dx.doi.org/10.1002/eji.201747172DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6531861PMC
June 2018

CTLA-4PD-1 Memory CD4 T Cells Critically Contribute to Viral Persistence in Antiretroviral Therapy-Suppressed, SIV-Infected Rhesus Macaques.

Immunity 2017 10;47(4):776-788.e5

Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA; Department of Medicine, Emory University School of Medicine, Atlanta, GA 30329, USA. Electronic address:

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http://dx.doi.org/10.1016/j.immuni.2017.09.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5679306PMC
October 2017

Elicitation of Robust Tier 2 Neutralizing Antibody Responses in Nonhuman Primates by HIV Envelope Trimer Immunization Using Optimized Approaches.

Immunity 2017 06;46(6):1073-1088.e6

Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA; Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery, The Scripps Research Institute, La Jolla, CA 92037, USA; IAVI Neutralizing Antibody Center and the Collaboration for AIDS Vaccine Discovery, The Scripps Research Institute, La Jolla, CA 92037, USA; Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology, and Harvard University, Cambridge, MA 02139, USA. Electronic address:

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http://dx.doi.org/10.1016/j.immuni.2017.05.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5483234PMC
June 2017

In Vivo Models of Human Immunodeficiency Virus Persistence and Cure Strategies.

J Infect Dis 2017 03;215(suppl_3):S142-S151

Division of Infectious Diseases, Center for AIDS Research, University of North Carolina at Chapel Hill School of Medicine.

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http://dx.doi.org/10.1093/infdis/jiw637DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5410984PMC
March 2017

Collapse of Cytolytic Potential in SIV-Specific CD8+ T Cells Following Acute SIV Infection in Rhesus Macaques.

PLoS Pathog 2016 Dec 30;12(12):e1006135. Epub 2016 Dec 30.

Department of Microbiology, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America.

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http://dx.doi.org/10.1371/journal.ppat.1006135DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5231392PMC
December 2016

Direct Probing of Germinal Center Responses Reveals Immunological Features and Bottlenecks for Neutralizing Antibody Responses to HIV Env Trimer.

Cell Rep 2016 11;17(9):2195-2209

Division of Vaccine Discovery, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA; Scripps Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery, La Jolla, CA 92037, USA; Department of Medicine, Division of Infectious Diseases, University of California, San Diego, La Jolla, CA 92037, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2016.10.085DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5142765PMC
November 2016

Quantifying integrated SIV-DNA by repetitive-sampling Alu-gag PCR.

J Virus Erad 2016 Oct 5;2(4):219-226. Epub 2016 Oct 5.

Yerkes National Primate Research Center, Emory University, Atlanta, GA, USA; Department of Pediatrics, Emory University School of Medicine, Atlanta, GA, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5075349PMC
October 2016

What pediatric nonprogressors and natural SIV hosts teach us about HIV.

Sci Transl Med 2016 09;8(358):358fs16

Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA. Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA.

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http://dx.doi.org/10.1126/scitranslmed.aaj1874DOI Listing
September 2016

Response to Comment on "A Cytokine-Independent Approach To Identify Antigen-Specific Human Germinal Center T Follicular Helper Cells and Rare Antigen-Specific CD4+ T Cells in Blood".

J Immunol 2016 10;197(7):2558

La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037; Division of Infectious Diseases, University of California, San Diego, La Jolla, CA 92093; Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery, La Jolla, CA 92037;

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http://dx.doi.org/10.4049/jimmunol.1601321DOI Listing
October 2016

Coexpression Network Analysis of Benign and Malignant Phenotypes of SIV-Infected Sooty Mangabey and Rhesus Macaque.

PLoS One 2016 9;11(6):e0156170. Epub 2016 Jun 9.

Hubei Bioinformatics and Molecular Imaging Key Laboratory, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, China.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0156170PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4900581PMC
July 2017

Neutralizing antibody affords comparable protection against vaginal and rectal simian/human immunodeficiency virus challenge in macaques.

AIDS 2016 06;30(10):1543-51

aDepartment of Immunology and Microbial Science, IAVI Neutralizing Antibody Center and Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery, The Scripps Research Institute, La Jolla, California bEmory Vaccine Center and Yerkes National Primate Research Center, Emory University, Atlanta, Georgia cCenter for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts dBioqual, Inc., Rockville, Maryland eBioinformatics and Systems Biology Program, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, California, USA fGenmab, Utrecht, The Netherlands gRagon Institute of MGH, MIT, and Harvard, Cambridge, Massachusetts, USA. *Present address: MedImmune, LLC, Gaithersburg, Maryland, USA.

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http://dx.doi.org/10.1097/QAD.0000000000001102DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4915739PMC
June 2016

Initiation of Antiretroviral Therapy Restores CD4+ T Memory Stem Cell Homeostasis in Simian Immunodeficiency Virus-Infected Macaques.

J Virol 2016 08 11;90(15):6699-6708. Epub 2016 Jul 11.

Emory Vaccine Center and Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA

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http://dx.doi.org/10.1128/JVI.00492-16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4944279PMC
August 2016

Animal models to achieve an HIV cure.

Curr Opin HIV AIDS 2016 07;11(4):432-41

aYerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA bEmory Vaccine Center, Emory University, Atlanta, GA 30329; USA cDepartment of Pediatrics, Emory University School of Medicine, Atlanta, GA 30329, USA dDepartment of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA 30329, USA.

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http://dx.doi.org/10.1097/COH.0000000000000290DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4922307PMC
July 2016

CD19xCD3 DART protein mediates human B-cell depletion in vivo in humanized BLT mice.

Mol Ther Oncolytics 2016 2;3:15024. Epub 2016 Mar 2.

Division of Infectious Diseases, Center for AIDS Research, University of North Carolina at Chapel Hill School of Medicine , Chapel Hill, North Carolina, USA.

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http://dx.doi.org/10.1038/mto.2015.24DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4824566PMC
April 2016

Immune activation in HIV infection: what can the natural hosts of simian immunodeficiency virus teach us?

Curr Opin HIV AIDS 2016 Mar;11(2):201-8

aInstitut Pasteur, Unité HIV, Inflammation and Persistence, Paris, France bDivision of Immunology and Microbiology, Yerkes National Primate Research Center, Atlanta, Georgia, USA.

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http://dx.doi.org/10.1097/COH.0000000000000238DOI Listing
March 2016

HIV and Tfh Cells: Circulating New Ideas to Identify and Protect.

Immunity 2016 Jan;44(1):16-18

Department of Pathology, Emory University School of Medicine, Atlanta, GA 30322, USA; Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA; Emory Vaccine Center, Emory University, Atlanta, GA 30329, USA. Electronic address:

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http://dx.doi.org/10.1016/j.immuni.2015.12.016DOI Listing
January 2016

Editorial overview: Host pathogens: New paradigms and tools to decipher and deconstruct the host-pathogen interaction.

Curr Opin Immunol 2015 Oct 7;36:v-viii. Epub 2015 Sep 7.

Center for Comparative Medicine, Department of Pathology and Laboratory Medicine, California National Primate Research Center, University of California at Davis, Davis, CA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.coi.2015.08.004DOI Listing
October 2015

Breakthrough of SIV strain smE660 challenge in SIV strain mac239-vaccinated rhesus macaques despite potent autologous neutralizing antibody responses.

Proc Natl Acad Sci U S A 2015 Aug 10;112(34):10780-5. Epub 2015 Aug 10.

Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329; Emory Vaccine Center, Emory University, Atlanta, GA 30329; Department of Pathology and Laboratory Medicine, Emory University, Atlanta, GA 30329;

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http://dx.doi.org/10.1073/pnas.1509731112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4553804PMC
August 2015

HIV therapeutic vaccines: moving towards a functional cure.

Curr Opin Immunol 2015 Aug 18;35:1-8. Epub 2015 May 18.

Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA 30322, USA; Emory Vaccine Center, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA. Electronic address:

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http://dx.doi.org/10.1016/j.coi.2015.05.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4553139PMC
August 2015

T memory stem cells and HIV: a long-term relationship.

Curr HIV/AIDS Rep 2015 Mar;12(1):33-40

Department of Pediatrics, Emory University School of Medicine, Atlanta, GA, USA,

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http://dx.doi.org/10.1007/s11904-014-0246-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4370789PMC
March 2015

The contribution of non-human primate models to the development of human vaccines.

Discov Med 2014 Dec;18(101):313-22

School of Chemistry and Molecular Biosciences and Australian Infectious Diseases Research Centre, The University of Queensland, Brisbane, QLD, 4072, Australia.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4465840PMC
December 2014

Lentiviral Nef proteins manipulate T cells in a subset-specific manner.

J Virol 2015 Feb 10;89(4):1986-2001. Epub 2014 Dec 10.

Institute of Molecular Virology, Ulm University Medical Center, Ulm, Germany

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http://dx.doi.org/10.1128/JVI.03104-14DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4338905PMC
February 2015

CD4 depletion in SIV-infected macaques results in macrophage and microglia infection with rapid turnover of infected cells.

PLoS Pathog 2014 Oct 30;10(10):e1004467. Epub 2014 Oct 30.

Division of Microbiology & Immunology, Yerkes National Primate Research Center, Emory University School of Medicine, Atlanta, Georgia, United States of America; Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia, United States of America.

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http://dx.doi.org/10.1371/journal.ppat.1004467DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4214815PMC
October 2014

Persistence of virus reservoirs in ART-treated SHIV-infected rhesus macaques after autologous hematopoietic stem cell transplant.

PLoS Pathog 2014 Sep 25;10(9):e1004406. Epub 2014 Sep 25.

Emory Vaccine Center and Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, United States of America; Center for Immunology and Vaccines, Children's Healthcare of Atlanta and Emory University School of Medicine, Atlanta, Georgia, United States of America.

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http://dx.plos.org/10.1371/journal.ppat.1004406
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http://dx.doi.org/10.1371/journal.ppat.1004406DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4177994PMC
September 2014

TRIM proteins regulate autophagy and can target autophagic substrates by direct recognition.

Dev Cell 2014 Aug 7;30(4):394-409. Epub 2014 Aug 7.

Department of Molecular Genetics and Microbiology, University of New Mexico Health Sciences Center, 915 Camino de Salud NE, Albuquerque, NM 87131, USA. Electronic address:

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http://dx.doi.org/10.1016/j.devcel.2014.06.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4146662PMC
August 2014

Taming HIV-related inflammation with physical activity: a matter of timing.

AIDS Res Hum Retroviruses 2014 Oct 17;30(10):936-44. Epub 2014 Sep 17.

1 Department of Public Health and Infectious Diseases, Istituto Pasteur-Fondazione Cenci Bolognetti, University of Rome "Sapienza," Rome, Italy .

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http://dx.doi.org/10.1089/AID.2014.0069DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4179917PMC
October 2014

Animal models for viral infection and cell exhaustion.

Curr Opin HIV AIDS 2014 Sep;9(5):492-9

aEmory Vaccine Center bYerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA.

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http://dx.doi.org/10.1097/COH.0000000000000093DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4180228PMC
September 2014