Guido Reifenberger

Guido Reifenberger

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Guido Reifenberger

Publications by authors named "Guido Reifenberger"

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Molecular targeted therapy of glioblastoma.

Cancer Treat Rev 2019 Nov 11;80:101896. Epub 2019 Sep 11.

Department of Neurology & Brain Tumor Center, University Hospital and University of Zurich, Zurich, Switzerland. Electronic address:

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http://dx.doi.org/10.1016/j.ctrv.2019.101896DOI Listing
November 2019

Synergistic growth inhibition mediated by dual PI3K/mTOR pathway targeting and genetic or direct pharmacological AKT inhibition in human glioblastoma models.

J Neurochem 2019 Oct 16. Epub 2019 Oct 16.

Laboratory of Molecular Neuro-Oncology, Department of Neurology, University Hospital and University of Zurich, Zurich, Switzerland.

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http://dx.doi.org/10.1111/jnc.14899DOI Listing
October 2019

cIMPACT-NOW: a practical summary of diagnostic points from Round 1 updates.

Brain Pathol 2019 07 22;29(4):469-472. Epub 2019 May 22.

Department of Pathology, Amsterdam University Medical Centers/VUmc, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1111/bpa.12732DOI Listing
July 2019

Data Sets for the Reporting of Tumors of the Central Nervous System.

Arch Pathol Lab Med 2019 Jun 20. Epub 2019 Jun 20.

From the Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts (Dr Louis); the Department of Pathology, Amsterdam Universities Medical Center/VUmc CCA Brain Tumor Center, Amsterdam, the Netherlands (Dr Wesseling); the Department of Pathology, Princess Máxima Center for Pediatric Oncology, and University Medical Center Utrecht, Utrecht, the Netherlands (Dr Wesseling); Division of Neuropathology, The National Hospital for Neurology and Neurosurgery, University College London NHS Foundation Trust, London, United Kingdom (Dr Brandner); the Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, London, United Kingdom (Dr Brandner); the Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, Illinois (Dr Brat); the Department of Pathology, St. Jude Children's Research Hospital, Memphis, Tennessee (Dr Ellison); the Department of Radiology, Oncology and Anatomic Pathology, University La Sapienza, Rome, Italy (Dr Giangaspero); IRCCS Neuromed, Pozzilli, Isernia, Italy (Dr Giangaspero); the Department of Pathology, University of Louisville School of Medicine, Louisville, Kentucky (Dr Hattab); the Department of Laboratory Medicine & Pathobiology, The Hospital for Sick Children, Toronto, Ontario, Canada (Dr Hawkins); Project Management Office, Royal College of Pathologists of Australasia, Sydney, Australia (Ms Judge); the Departments of Pathology, Neurology, and Neurosurgery, University of Colorado, Aurora (Dr Kleinschmidt-DeMasters); the Department of Laboratory Medicine and Pathology (Neuropathology), Tokyo Metropolitan Neurological Hospital, Tokyo, Japan (Dr Komori); the Department of Pathology, Tokyo Women's Medical University School of Medicine, Tokyo, Japan (Dr Komori); Alfred Anatomical Pathology and NNF, Victorian Brain Bank, Carlton, Victoria, Australia (Dr McLean); Institute of Neuropathology, University Hospital Münster, Münster, Germany (Dr Paulus); Division of Neuropathology, Department of Pathology, University of California, San Francisco (Dr Perry); the Department of Neuropathology, Heinrich Heine University, Düsseldorf, Germany (Dr Reifenberger); German Cancer Consortium (DKTK), Partner Site Essen/Düsseldorf, Düsseldorf, Germany (Dr Reifenberger); the Department of Neurology, University Hospital and University of Zurich, Zurich, Switzerland (Dr Weller); and the Department of Histopathology, Addenbrookes Hospital, Cambridge, United Kingdom (Dr Rous); ICCR Steering Group Representative (Dr Rous).

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http://dx.doi.org/10.5858/arpa.2018-0565-OADOI Listing
June 2019

Sensitive detection of hydroxymethylcytosine levels in normal and neoplastic cells and tissues.

Electrophoresis 2019 05 14;40(9):1293-1297. Epub 2019 Feb 14.

Division of Radiopharmaceutical Chemistry, Heidelberg, Germany.

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https://onlinelibrary.wiley.com/doi/abs/10.1002/elps.2018005
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http://dx.doi.org/10.1002/elps.201800523DOI Listing
May 2019

cIMPACT-NOW update 4: diffuse gliomas characterized by MYB, MYBL1, or FGFR1 alterations or BRAF mutation.

Acta Neuropathol 2019 Apr 8;137(4):683-687. Epub 2019 Mar 8.

Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, 02114, USA.

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http://dx.doi.org/10.1007/s00401-019-01987-0DOI Listing
April 2019

Evolutionary Trajectories of IDH Glioblastomas Reveal a Common Path of Early Tumorigenesis Instigated Years ahead of Initial Diagnosis.

Cancer Cell 2019 Apr 21;35(4):692-704.e12. Epub 2019 Mar 21.

Division of Molecular Genetics, German Cancer Research Consortium (DKTK), German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120 Heidelberg, Germany; Heidelberg Center for Personalized Oncology, DKFZ-HIPO, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120 Heidelberg, Germany. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S15356108193010
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http://dx.doi.org/10.1016/j.ccell.2019.02.007DOI Listing
April 2019

ROBO1 Expression in Metastasizing Breast and Ovarian Cancer: SLIT2-induced Chemotaxis Requires Heparan Sulfates (Heparin).

Anticancer Res 2019 Mar;39(3):1267-1273

Department of Obstetrics and Gynecology, Marien Hospital Herne, Ruhr-Universität Bochum, Bochum, Germany.

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http://dx.doi.org/10.21873/anticanres.13237DOI Listing
March 2019

EGFR Cooperates with EGFRvIII to Recruit Macrophages in Glioblastoma.

Cancer Res 2018 12 6;78(24):6785-6794. Epub 2018 Nov 6.

Department of Neurology, University of California, San Francisco, San Francisco, California.

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http://dx.doi.org/10.1158/0008-5472.CAN-17-3551DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6295222PMC
December 2018

D-2-Hydroxyglutarate Is an Intercellular Mediator in IDH-Mutant Gliomas Inhibiting Complement and T Cells.

Clin Cancer Res 2018 11 13;24(21):5381-5391. Epub 2018 Jul 13.

Department of Immunology, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio.

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http://dx.doi.org/10.1158/1078-0432.CCR-17-3855DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6214730PMC
November 2018

Transcriptional control of O -methylguanine DNA methyltransferase expression and temozolomide resistance in glioblastoma.

J Neurochem 2018 03;144(6):780-790

Department of Neurology, Laboratory of Molecular Neuro-Oncology, University Hospital and University of Zurich, Zurich, Switzerland.

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http://doi.wiley.com/10.1111/jnc.14326
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http://dx.doi.org/10.1111/jnc.14326DOI Listing
March 2018

DNA methylation-based classification of central nervous system tumours.

Authors:
David Capper David T W Jones Martin Sill Volker Hovestadt Daniel Schrimpf Dominik Sturm Christian Koelsche Felix Sahm Lukas Chavez David E Reuss Annekathrin Kratz Annika K Wefers Kristin Huang Kristian W Pajtler Leonille Schweizer Damian Stichel Adriana Olar Nils W Engel Kerstin Lindenberg Patrick N Harter Anne K Braczynski Karl H Plate Hildegard Dohmen Boyan K Garvalov Roland Coras Annett Hölsken Ekkehard Hewer Melanie Bewerunge-Hudler Matthias Schick Roger Fischer Rudi Beschorner Jens Schittenhelm Ori Staszewski Khalida Wani Pascale Varlet Melanie Pages Petra Temming Dietmar Lohmann Florian Selt Hendrik Witt Till Milde Olaf Witt Eleonora Aronica Felice Giangaspero Elisabeth Rushing Wolfram Scheurlen Christoph Geisenberger Fausto J Rodriguez Albert Becker Matthias Preusser Christine Haberler Rolf Bjerkvig Jane Cryan Michael Farrell Martina Deckert Jürgen Hench Stephan Frank Jonathan Serrano Kasthuri Kannan Aristotelis Tsirigos Wolfgang Brück Silvia Hofer Stefanie Brehmer Marcel Seiz-Rosenhagen Daniel Hänggi Volkmar Hans Stephanie Rozsnoki Jordan R Hansford Patricia Kohlhof Bjarne W Kristensen Matt Lechner Beatriz Lopes Christian Mawrin Ralf Ketter Andreas Kulozik Ziad Khatib Frank Heppner Arend Koch Anne Jouvet Catherine Keohane Helmut Mühleisen Wolf Mueller Ute Pohl Marco Prinz Axel Benner Marc Zapatka Nicholas G Gottardo Pablo Hernáiz Driever Christof M Kramm Hermann L Müller Stefan Rutkowski Katja von Hoff Michael C Frühwald Astrid Gnekow Gudrun Fleischhack Stephan Tippelt Gabriele Calaminus Camelia-Maria Monoranu Arie Perry Chris Jones Thomas S Jacques Bernhard Radlwimmer Marco Gessi Torsten Pietsch Johannes Schramm Gabriele Schackert Manfred Westphal Guido Reifenberger Pieter Wesseling Michael Weller Vincent Peter Collins Ingmar Blümcke Martin Bendszus Jürgen Debus Annie Huang Nada Jabado Paul A Northcott Werner Paulus Amar Gajjar Giles W Robinson Michael D Taylor Zane Jaunmuktane Marina Ryzhova Michael Platten Andreas Unterberg Wolfgang Wick Matthias A Karajannis Michel Mittelbronn Till Acker Christian Hartmann Kenneth Aldape Ulrich Schüller Rolf Buslei Peter Lichter Marcel Kool Christel Herold-Mende David W Ellison Martin Hasselblatt Matija Snuderl Sebastian Brandner Andrey Korshunov Andreas von Deimling Stefan M Pfister

Nature 2018 03 14;555(7697):469-474. Epub 2018 Mar 14.

Hopp Children's Cancer Center at the NCT Heidelberg (KiTZ), Heidelberg, Germany.

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http://dx.doi.org/10.1038/nature26000DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6093218PMC
March 2018

Mutations in Pituitary Cushing Adenomas-Targeted Analysis by Next-Generation Sequencing.

J Endocr Soc 2018 Mar 19;2(3):266-278. Epub 2018 Feb 19.

Department of Nephrology, School of Medicine, Heinrich Heine University Düsseldorf, Düsseldorf, Germany.

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http://dx.doi.org/10.1210/js.2017-00364DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5838826PMC
March 2018

Evidence-based management of adult patients with diffuse glioma - Authors' reply.

Lancet Oncol 2017 08 26;18(8):e430-e431. Epub 2017 Jul 26.

Neurology Clinic and National Centre for Tumour Diseases, University Hospital Heidelberg, Heidelberg, Germany; German Consortium of Translational Cancer Research, Clinical Cooperation Unit Neurooncology, German Cancer Research Center, Heidelberg, Germany.

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http://dx.doi.org/10.1016/S1470-2045(17)30515-6DOI Listing
August 2017

Advances in the molecular genetics of gliomas - implications for classification and therapy.

Nat Rev Clin Oncol 2017 Jul 29;14(7):434-452. Epub 2016 Dec 29.

Department of Neurology and Brain Tumour Centre, Cancer Centre Zürich, University Hospital and University of Zürich, Frauenklinikstrasse 26, CH-8091 Zürich, Switzerland.

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http://dx.doi.org/10.1038/nrclinonc.2016.204DOI Listing
July 2017

European Association for Neuro-Oncology (EANO) guideline on the diagnosis and treatment of adult astrocytic and oligodendroglial gliomas.

Lancet Oncol 2017 06 5;18(6):e315-e329. Epub 2017 May 5.

Neurology Clinic and National Centre for Tumour Diseases, University Hospital Heidelberg, Heidelberg, Germany; German Consortium of Translational Cancer Research (DKTK), Clinical Cooperation Unit Neurooncology, German Cancer Research Center, Heidelberg, Germany.

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http://dx.doi.org/10.1016/S1470-2045(17)30194-8DOI Listing
June 2017

Abstracts of the 52nd Workshop for Pediatric Research : Frankfurt, Germany. 27-28 October 2016.

Authors:
Rhea van den Bruck Patrick P Weil Thomas Ziegenhals Philipp Schreiner Stefan Juranek Daniel Gödde Silvia Vogel Frauke Schuster Valerie Orth Johannes Dörner Daniel Pembaur Meike Röper Stefan Störkel Hubert Zirngibl Stefan Wirth Andreas C W Jenke Jan Postberg Nikolas Boy Jana Heringer Gisela Haege Esther M Glahn Georg F Hoffmann Sven F Garbade Peter Burgard Stefan Kölker Cho-Ming Chao Faady Yahya Alena Moiseenko Amit Shrestha Negah Ahmadvand Jennifer Quantius Jochen Wilhelm Elie El-Agha Klaus-Peter Zimmer Saverio Bellusci Christian Staufner Stefan Kölker Holger Prokisch Georg F Hoffmann Stephan Seeliger Matthias Müller Andreas Hippe Henrik Steinkraus Roland Wauer Burkhard Lachmann Sigrun R Hofmann Christian M Hedrich Jakob Zierk Farhad Arzideh Rainer Haeckel Wolfgang Rascher Manfred Rauh Markus Metzler Sebastian Thieme Joanna Bandoła Cornelia Richter Martin Ryser Arshad Jamal Michelle P Ashton Malte von Bonin Matthias Kuhn Christian M Hedrich Ezio Bonifacio Reinhard Berner Sebastian Brenner Johanna Hammersen Cristina Has Nora Naumann-Bartsch Daniel Stachel Dimitra Kiritsi Stephan Söder Mathilde Tardieu Markus Metzler Leena Bruckner-Tuderman Holm Schneider F Bohne D Langer R Cencic T Eggermann U Zechner J Pelletier F Zepp T Enklaar D Prawitt Martin Pech Markus Weckmann Femke-Anouska Heinsen Andre Franke Christine Happle Anna-Maria Dittrich Gesine Hansen Oliver Fuchs Erika von Mutius Brian G Oliver Matthias V Kopp Claudia Paret Alexandra Russo Johanna Theruvath Bettina Keller Khalifa El Malki Nadine Lehmann Arthur Wingerter Marie A Neu Gerhold-Ay Aslihan Wolfgang Wagner Clemens Sommer Torsten Pietsch Larissa Seidmann Jörg Faber Felix Schreiner Merle Ackermann Michael Michalik Eva Rother Andras Bilkei-Gorzo Ildiko Racz Laura Bindila Beat Lutz Jörg Dötsch Andreas Zimmer Joachim Woelfle Hendrik S Fischer Tim L Ullrich Christoph Bührer Christoph Czernik Gerd Schmalisch Robert Stein Sigrun R Hofmann Judith Hagenbuchner Ursula Kiechl-Kohlendorfer Petra Obexer Michael J Ausserlechner Niki T Loges Adrien Tobias Frommer Julia Wallmeier Heymut Omran Soner Öner-Sieben Martina Gimpfl Jan Rozman Martin Irmler Johannes Beckers Martin Hrabe De Angelis Adelbert Roscher Eckhard Wolf Regina Ensenauer Karolina Nemes Michael Frühwald Martin Hasselblatt Reiner Siebert Uwe Kordes Marcel Kool Haicui Wang Holly Hardy Osama Refai Katy E S Barwick Holly H Zimmerman Joachim Weis Emma L Baple Andrew H Crosby Sebahattin Cirak C Hellmuth O Uhl M Standl J Heinrich E Thiering B Koletzko Lena Blümel Kornelius Kerl Daniel Picard Michael C Frühwald Max C Liebau Guido Reifenberger Arndt Borkhardt Martin Hasselblatt Marc Remke D Tews M Wabitsch P Fischer-Posovszky Mike-Andrew Westhoff Lisa Nonnenmacher Julia Langhans Lukas Schneele Nancy Trenkler Klaus-Michael Debatin

Mol Cell Pediatr 2017 May;4(Suppl 1)

Department of Pediatrics and Adolescent Medicine, University Medical Center Ulm, Ulm, Germany.

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http://dx.doi.org/10.1186/s40348-017-0071-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5435609PMC
May 2017

Multidimensional scaling of diffuse gliomas: application to the 2016 World Health Organization classification system with prognostically relevant molecular subtype discovery.

Acta Neuropathol Commun 2017 05 22;5(1):39. Epub 2017 May 22.

Division of Human Biology, and Seattle Tumor and Translational Research, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N., Mailstop C3-168, Seattle, WA, 98109, USA.

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http://dx.doi.org/10.1186/s40478-017-0443-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5439117PMC
May 2017

Limited role for extended maintenance temozolomide for newly diagnosed glioblastoma.

Neurology 2017 Apr 15;88(15):1422-1430. Epub 2017 Mar 15.

From the Department of Neurology and Brain Tumor Center (D.G., M.W.), University Hospital Zurich and University of Zurich, Switzerland; Department of Neuroradiology (P.K., M.B.), University Hospital of Heidelberg; Institute for Medical Informatics, Statistics and Epidemiology (B.H., M.L.), University of Leipzig; Departments of Neuropathology (J.F., G.R.) and Neurosurgery (M.S.), Heinrich-Heine University Düsseldorf; Division of Neurooncology (U.H.), Department of Neurology, University Medical Center Bonn; Department of Neurosurgery (G.S.), University of Dresden; Department of Neurosurgery (J.-C.T.), Ludwig Maximilians University Munich; Department of Neurosurgery (M.W.), University Medical Center Hamburg-Eppendorf, Hamburg; Department of Neurology (U.S.), Knappschaftskrankenhaus Bochum-Langendreer, Ruhr-University Bochum; Clinical Cooperation Unit Neurooncology (W.W.), German Cancer Consortium, German Cancer Research Center, and Neurology Clinic and National Center for Tumor Diseases, University Hospital Heidelberg; Department of Neuropathology (T.P.), DGNN Brain Tumor Reference Center, University of Bonn Medical School; and German Cancer Consortium (G.R.), German Cancer Research Center Heidelberg, Partner Site Essen/Düsseldorf, Düsseldorf, Germany.

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http://dx.doi.org/10.1212/WNL.0000000000003809DOI Listing
April 2017

Molecular Diagnostics of Gliomas Using Next Generation Sequencing of a Glioma-Tailored Gene Panel.

Brain Pathol 2017 03 19;27(2):146-159. Epub 2016 Apr 19.

Department of Neuropathology, Heinrich Heine University Düsseldorf, Düsseldorf, Germany.

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http://dx.doi.org/10.1111/bpa.12367DOI Listing
March 2017

Molecular classification of gliomas.

Handb Clin Neurol 2016 ;134:97-120

Department of Neuropathology, Heinrich Heine University, Düsseldorf, Germany. Electronic address:

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http://dx.doi.org/10.1016/B978-0-12-802997-8.00006-2DOI Listing
December 2016

Limited role for transforming growth factor-β pathway activation-mediated escape from VEGF inhibition in murine glioma models.

Neuro Oncol 2016 12 10;18(12):1610-1621. Epub 2016 Jun 10.

Laboratory of Molecular Neuro-Oncology, Department of Neurology, University Hospital and University of Zurich, Zurich, Switzerland (D.M., M.W., E.S.S., K.S., G.T., H.S.); Center for Neuroscience, University of Zurich, Zurich, Switzerland (M.W., G.T.); Interdisciplinary Center for Bioinformatics, University of Leipzig, Leipzig, Germany (E.W., H.B.); Institute of Neuropathology, Heinrich Heine University, Düsseldorf, Germany (G.R.); German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ) Heidelberg, partner site, Essen/Düsseldorf, Germany (G.R.).

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http://dx.doi.org/10.1093/neuonc/now112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6693192PMC
December 2016

Long-term analysis of the NOA-04 randomized phase III trial of sequential radiochemotherapy of anaplastic glioma with PCV or temozolomide.

Neuro Oncol 2016 11 1;18(11):1529-1537. Epub 2016 Jul 1.

Department of Neurology Clinic, University of Heidelberg, Heidelberg, Germany (W.W., A.W., M.P., B.W.); Clinical Cooperation Unit (CCU Neurooncology), German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany (W.W., B.W.); Department of Neurology, University Hospital and University of Zurich, Zurich, Switzerland (P.R., C.H., M.W.); Department of Neuropathology, Hannover Medical School, Hannover, Germany (C.H.); Department of Neurology, Regensburg University, Regensburg, Germany (P.H.); Department of Neurosurgery Clinic, Hannover Medical School, Hannover, Germany (M.N.); Department of Neurosurgery Clinic, Charité, Berlin, Germany (F.S., P.V.); Department of Neurosurgery, Heinrich Heine University, Düsseldorf, Germany (M.C.S.); Department of Neurology Clinic, Essen Medical Center, Essen, Germany (S.K.); Department of Neurosurgery Clinic, Saarland University, Homburg, Germany (R.K.); Department of Neurosurgery Clinic, University of Göttingen, Göttingen, Germany (F.S.); Department of Neurosurgery Clinic, University of Erlangen, Erlangen, Germany (I.E.); Department of Neurosurgery Clinic, University of Jena, Jena, Germany (R.K.); Department of Neurology Clinic, Cologne University, Cologne, Germany (N.G.); Department of Neurology Clinic, TU Munich, Munich, Germany (F.S.-G.); Department of Neuropathology, University of Heidelberg, Heidelberg, Germany (A.v.D.); CCU Neuropathology, (C.H., A.v.D.); CCU Brain Tumor Immunology, DKFZ, all Heidelberg, Germany (M.P.); Department of Neuropathology, Heinrich Heine University, Düsseldorf, Germany (G.R.); DKTK partner site Essen/Düsseldorf, Düsseldorf, Germany (G.R.), Department of General Neurology, Tübingen, Germany (W.W., A.W., F.S.-G., M.P., M.W.), Department of Radiation Oncology, Tübingen, Germany (M.B.), Department of Medical Biometry, University Hospital Tübingen, Tübingen, Germany (C.M.).

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http://dx.doi.org/10.1093/neuonc/now133DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5063521PMC
November 2016

Practical implications of integrated glioma classification according to the World Health Organization classification of tumors of the central nervous system 2016.

Curr Opin Oncol 2016 11;28(6):494-501

aDepartment of Neuropathology, Heinrich-Heine-University bGerman Cancer Consortium (DKTK), partner site Essen/Düsseldorf, Germany.

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http://pdfs.journals.lww.com/co-oncology/2016/11000/Practica
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http://dx.doi.org/10.1097/CCO.0000000000000327DOI Listing
November 2016

The 2016 World Health Organization Classification of Tumors of the Central Nervous System: a summary.

Acta Neuropathol 2016 06 9;131(6):803-20. Epub 2016 May 9.

Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN, USA.

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http://dx.doi.org/10.1007/s00401-016-1545-1DOI Listing
June 2016

Role of microRNAs Located on Chromosome Arm 10q in Malignant Gliomas.

Brain Pathol 2016 05 9;26(3):344-58. Epub 2015 Sep 9.

Department of Neuropathology, Heinrich Heine University, Düsseldorf, Germany.

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http://dx.doi.org/10.1111/bpa.12294DOI Listing
May 2016

Complete resection of contrast-enhancing tumor volume is associated with improved survival in recurrent glioblastoma-results from the DIRECTOR trial.

Neuro Oncol 2016 Apr 27;18(4):549-56. Epub 2016 Jan 27.

Department of Neurosurgery, Ludwig-Maximilians University Munich, Munich, Germany (B.S., J.C.T.); Department of Neurology, University Hospital Zurich, Zurich, Switzerland (M.W., G.T., H.-G.W.); Department of Neurology, University Hospital Tübingen, Tübingen, Germany (G.T.); Department of Neurosurgery, University Hospital Frankfurt, Frankfurt am Main, Germany (C.S.); Department of Neurology, University Hospital Regensburg, Regensburg, Germany (P.H.); Department of Neurosurgery, University Hospital Düsseldorf, Düsseldorf, Germany (M.C.S.); Department of Neurology, University Hospital Bonn, Bonn, Germany (U.H.); Department of Neurosurgery, University Hospital Saarland, Homburg/Saar, Germany (R.K.); Department of Neurology, Knappschaftskrankenhaus Bochum, Bochum, Germany (U.S.); Department of Oncology, Vienna General Hospital, Vienna, Austria (C.M.); Institute of Neuropathology, University Hospital Düsseldorf, Düsseldorf, Germany (G.R.); Department of Neurology, University Hospital Heidelberg, Heidelberg, Germany (W.W.).

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http://neuro-oncology.oxfordjournals.org/content/early/2016/
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http://neuro-oncology.oxfordjournals.org/lookup/doi/10.1093/
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http://dx.doi.org/10.1093/neuonc/nov326DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4799687PMC
April 2016

Control of glioma cell migration and invasiveness by GDF-15.

Oncotarget 2016 Feb;7(7):7732-46

Laboratory of Molecular Neuro-Oncology, Department of Neurology, University Hospital Zurich and University of Zurich, Zurich, Switzerland.

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http://dx.doi.org/10.18632/oncotarget.6816DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4884950PMC
February 2016

New Brain Tumor Entities Emerge from Molecular Classification of CNS-PNETs.

Authors:
Dominik Sturm Brent A Orr Umut H Toprak Volker Hovestadt David T W Jones David Capper Martin Sill Ivo Buchhalter Paul A Northcott Irina Leis Marina Ryzhova Christian Koelsche Elke Pfaff Sariah J Allen Gnanaprakash Balasubramanian Barbara C Worst Kristian W Pajtler Sebastian Brabetz Pascal D Johann Felix Sahm Jüri Reimand Alan Mackay Diana M Carvalho Marc Remke Joanna J Phillips Arie Perry Cynthia Cowdrey Rachid Drissi Maryam Fouladi Felice Giangaspero Maria Łastowska Wiesława Grajkowska Wolfram Scheurlen Torsten Pietsch Christian Hagel Johannes Gojo Daniela Lötsch Walter Berger Irene Slavc Christine Haberler Anne Jouvet Stefan Holm Silvia Hofer Marco Prinz Catherine Keohane Iris Fried Christian Mawrin David Scheie Bret C Mobley Matthew J Schniederjan Mariarita Santi Anna M Buccoliero Sonika Dahiya Christof M Kramm André O von Bueren Katja von Hoff Stefan Rutkowski Christel Herold-Mende Michael C Frühwald Till Milde Martin Hasselblatt Pieter Wesseling Jochen Rößler Ulrich Schüller Martin Ebinger Jens Schittenhelm Stephan Frank Rainer Grobholz Istvan Vajtai Volkmar Hans Reinhard Schneppenheim Karel Zitterbart V Peter Collins Eleonora Aronica Pascale Varlet Stephanie Puget Christelle Dufour Jacques Grill Dominique Figarella-Branger Marietta Wolter Martin U Schuhmann Tarek Shalaby Michael Grotzer Timothy van Meter Camelia-Maria Monoranu Jörg Felsberg Guido Reifenberger Matija Snuderl Lynn Ann Forrester Jan Koster Rogier Versteeg Richard Volckmann Peter van Sluis Stephan Wolf Tom Mikkelsen Amar Gajjar Kenneth Aldape Andrew S Moore Michael D Taylor Chris Jones Nada Jabado Matthias A Karajannis Roland Eils Matthias Schlesner Peter Lichter Andreas von Deimling Stefan M Pfister David W Ellison Andrey Korshunov Marcel Kool

Cell 2016 Feb;164(5):1060-1072

Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), 69120 Heidelberg, Germany.

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http://www.cell.com/cell/pdf/S0092-8674(16)00055-6.pdf
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http://www.cell.com/cms/attachment/2048488015/2058390163/mmc
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http://linkinghub.elsevier.com/retrieve/pii/S009286741600055
Publisher Site
http://dx.doi.org/10.1016/j.cell.2016.01.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5139621PMC
February 2016

Glioma.

Nat Rev Dis Primers 2015 07 16;1:15017. Epub 2015 Jul 16.

Department of Neuropathology, Heinrich Heine University Düsseldorf, and German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ) Heidelberg, partner site Essen/Düsseldorf, Germany.

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http://dx.doi.org/10.1038/nrdp.2015.17DOI Listing
July 2015

Glioblastoma: pathology, molecular mechanisms and markers.

Acta Neuropathol 2015 Jun 6;129(6):829-48. Epub 2015 May 6.

Princess Margaret Cancer Centre and MacFeeters-Hamilton Centre for Neuro-Oncology Research, 101 College St., Toronto, ON, M5G 1L7, Canada,

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http://dx.doi.org/10.1007/s00401-015-1432-1DOI Listing
June 2015

miR-23a-3p causes cellular senescence by targeting hyaluronan synthase 2: possible implication for skin aging.

J Invest Dermatol 2015 Feb 29;135(2):369-377. Epub 2014 Sep 29.

Institut für Pharmakologie und Klinische Pharmakologie, Universitätsklinikum der Heinrich-Heine-Universität, Düsseldorf, Germany. Electronic address:

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http://dx.doi.org/10.1038/jid.2014.422DOI Listing
February 2015

5-ALA-induced fluorescence behavior of reactive tissue changes following glioblastoma treatment with radiation and chemotherapy.

Acta Neurochir (Wien) 2015 Feb 30;157(2):207-13; discussion 213-4. Epub 2014 Dec 30.

Department of Neurosurgery, Medical Faculty, Heinrich Heine University Düsseldorf, Moorenstraße 5, 40225, Düsseldorf, Germany,

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http://dx.doi.org/10.1007/s00701-014-2313-4DOI Listing
February 2015

The usefulness of dynamic O-(2-18F-fluoroethyl)-L-tyrosine PET in the clinical evaluation of brain tumors in children and adolescents.

J Nucl Med 2015 Jan 18;56(1):88-92. Epub 2014 Dec 18.

Institute of Neuroscience and Medicine, Research Center Jülich, Jülich, Germany Department of Neurology, University of Cologne, Cologne, Germany Center of Integrated Oncology (CIO), University of Cologne, Cologne, Germany

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http://dx.doi.org/10.2967/jnumed.114.148734DOI Listing
January 2015

Assessing CpG island methylator phenotype, 1p/19q codeletion, and MGMT promoter methylation from epigenome-wide data in the biomarker cohort of the NOA-04 trial.

Neuro Oncol 2014 Dec 15;16(12):1630-8. Epub 2014 Jul 15.

Department of Neurooncology (B.W., M.P., W.W.); Department of Neuropathology (D.C., A.v.D.); Department of Pediatric Oncology, Hematology, and Immunology, Heidelberg University Hospital (S.M.P.); Clinical Cooperation Units Neurooncology (B.W., W.W.), Neuropathology (D.C, A.v.D.); Neuroimmunology and Brain Tumor Immunology (M.P.); Division of Molecular Genetics (V.H.); Division of Biostatistics (M.S.); Division of Pediatric Neurooncology (S.M.P., D.T.W.J.), German Cancer Research Center (DKFZ), Heidelberg, Germany (O.D.W.) and German Cancer Consortium (DKTK); Department for Neuropathology, Institute of Pathology, Medical University of Hannover, Hannover, Germany (C.H.); Department of Neuropathology, Heinrich-Heine-University, Düsseldorf, Germany (J.F., G.R.); German Consortium for Translational Cancer Research (DKTK), Düsseldorf, Germany (M.P., G.R.); Institute for Neuropathology, Saarland University, 66421 Saarbrücken, Germany (W.F.); Institute for Neuropathology, University of Essen Medical School, Essen, Germany (K.K.); Institute for Neuropathology, University of Tübingen, Tübingen, Germany (R.M.); Department of Neuropathology, University of Bonn Medical Center, Bonn, Germany (T.P.); Department of Neurology, University Hospital Zurich, Zürich, Switzerland (M.W.).

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http://dx.doi.org/10.1093/neuonc/nou138DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4232086PMC
December 2014

How stemlike are sphere cultures from long-term cancer cell lines? Lessons from mouse glioma models.

J Neuropathol Exp Neurol 2014 Nov;73(11):1062-77

From the Laboratory of Molecular Neuro-Oncology, Departments of Neurology (MA, PR, MW) and Neurosurgery (MA, KF); University Hospital Zurich, and Neuroscience Center (MA, KF, PR, MW), University of Zurich, Zurich, Switzerland; Interdisciplinary Institute for Bioinformatics, University of Leipzig, Leipzig, Germany (EW, HB); Molecular Proteomics Laboratory, Center for Biological and Medical Research (BMFZ) (AS, KS); Department of Neuropathology and German Cancer Consortium (DKTK), partner site Essen/Düsseldorf (KK, GR); and Institute for Molecular Medicine (KS), Heinrich Heine University, Düsseldorf, Germany.

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https://academic.oup.com/jnen/article-lookup/doi/10.1097/NEN
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http://dx.doi.org/10.1097/NEN.0000000000000130DOI Listing
November 2014

Proteome-wide analysis reveals an age-associated cellular phenotype of in situ aged human fibroblasts.

Aging (Albany NY) 2014 Oct;6(10):856-78

Institute for Molecular Medicine, Heinrich-Heine-University, Düsseldorf, Germany. Molecular Proteomics Laboratory, Biomedical Research Centre (BMFZ), Heinrich-Heine-University, Düsseldorf, Germany.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4247387PMC
http://dx.doi.org/10.18632/aging.100698DOI Listing
October 2014

MicroRNA-mediated down-regulation of NKG2D ligands contributes to glioma immune escape.

Oncotarget 2014 Sep;5(17):7651-62

Laboratory of Molecular Neuro-Oncology, Department of Neurology, University Hospital Zurich, Switzerland.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4202151PMC
http://dx.doi.org/10.18632/oncotarget.2287DOI Listing
September 2014

EANO guideline for the diagnosis and treatment of anaplastic gliomas and glioblastoma.

Lancet Oncol 2014 Aug;15(9):e395-403

Department of Neurooncology, Neurology Clinic & National Center for Tumor Diseases, University Hospital Heidelberg, Germany; German Consortium of Translational Cancer Research, Clinical Cooperation Unit Neurooncology, German Cancer Research Center, Heidelberg, Germany.

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https://linkinghub.elsevier.com/retrieve/pii/S14702045147001
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http://dx.doi.org/10.1016/S1470-2045(14)70011-7DOI Listing
August 2014

MGMT testing--the challenges for biomarker-based glioma treatment.

Nat Rev Neurol 2014 Jul 10;10(7):372-85. Epub 2014 Jun 10.

Department of Neuropathology, Heinrich Heine University, Germany.

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http://dx.doi.org/10.1038/nrneurol.2014.100DOI Listing
July 2014

Enhancer hijacking activates GFI1 family oncogenes in medulloblastoma.

Nature 2014 Jul 22;511(7510):428-34. Epub 2014 Jun 22.

1] Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg 69120, Germany [2] Department of Pediatric Oncology, Hematology & Immunology, Heidelberg University Hospital, Im Neuenheimer Feld 430, Heidelberg 69120, Germany.

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http://www.abta.org/resources/enhancers-hijacking-activates.
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http://www.nature.com/doifinder/10.1038/nature13379
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http://dx.doi.org/10.1038/nature13379DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4201514PMC
July 2014

The hallmarks of fibroblast ageing.

Mech Ageing Dev 2014 Jun 29;138:26-44. Epub 2014 Mar 29.

Institute of Clinical Chemistry and Laboratory Diagnostics, Heinrich-Heine-University, Med. Faculty, Düsseldorf, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.mad.2014.03.004DOI Listing
June 2014

Interferon-β induces loss of spherogenicity and overcomes therapy resistance of glioblastoma stem cells.

Mol Cancer Ther 2014 Apr 13;13(4):948-61. Epub 2014 Feb 13.

Authors' Affiliations: Laboratory of Molecular Neuro-Oncology, Department of Neurology, and Department of Neurosurgery, University Hospital Zurich and Neuroscience Center Zurich, Zurich, Switzerland; Laboratory for Brain Tumor Biology, Department of Neurosurgery, University Hospital Hamburg-Eppendorf, Hamburg; Department of Neuropathology and Center for Biological and Medical Research, Heinrich Heine University, Düsseldorf; and German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.

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http://mct.aacrjournals.org/cgi/doi/10.1158/1535-7163.MCT-13
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http://dx.doi.org/10.1158/1535-7163.MCT-13-0772DOI Listing
April 2014

Genome sequencing of SHH medulloblastoma predicts genotype-related response to smoothened inhibition.

Cancer Cell 2014 Mar;25(3):393-405

Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), 69121 Heidelberg, Germany; Department of Pediatric Oncology, Hematology and Immunology, University Hospital Heidelberg, 69120 Heidelberg, Germany.

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http://dx.doi.org/10.1016/j.ccr.2014.02.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4493053PMC
March 2014

Thymosin β 4 gene silencing decreases stemness and invasiveness in glioblastoma.

Brain 2014 Feb 18;137(Pt 2):433-48. Epub 2013 Dec 18.

1 Department of Neurology, Laboratory of Molecular Neuro-Oncology, University Hospital Zurich, Zurich, Switzerland.

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http://dx.doi.org/10.1093/brain/awt333DOI Listing
February 2014

MiR-328 promotes glioma cell invasion via SFRP1-dependent Wnt-signaling activation.

Neuro Oncol 2014 Jan 4;16(2):179-90. Epub 2013 Dec 4.

Corresponding author: Markus J. Riemenschneider, MD, Department of Neuropathology, Regensburg University Hospital, Franz-Josef-Strauß-Allee 11, 93053 Regensburg, Germany.

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http://dx.doi.org/10.1093/neuonc/not164DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3895379PMC
January 2014