Guido Marcucci

Guido Marcucci

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Guido Marcucci

Publications by authors named "Guido Marcucci"

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Protein lysine 43 methylation by EZH1 promotes AML1-ETO transcriptional repression in leukemia.

Nat Commun 2019 Nov 7;10(1):5051. Epub 2019 Nov 7.

Department of Hematology-Oncology, International Cancer Center, Shenzhen University General Hospital, Shenzhen University Health Science Center, 1098 Xueyuan Ave, 518060, Shenzhen, China.

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http://dx.doi.org/10.1038/s41467-019-12960-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6838331PMC
November 2019

Targeting PRMT1-mediated FLT3 methylation disrupts maintenance of MLL-rearranged acute lymphoblastic leukemia.

Blood 2019 Oct;134(15):1257-1268

Department of Hematological Malignancies Translational Science, Gehr Family Center for Leukemia Research, Hematologic Malignancies and Stem Cell Transplantation Institute, Beckman Research Institute, City of Hope Medical Center, Duarte, CA.

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http://dx.doi.org/10.1182/blood.2019002457DOI Listing
October 2019

Venetoclax and hypomethylating agents in TP53-mutated acute myeloid leukaemia.

Br J Haematol 2019 Oct 22;187(2):e45-e48. Epub 2019 Aug 22.

Department of Hematology and Hematopoietic Cell Transplantation, Gehr Family Center for Leukemia Research, City of Hope, Duarte, CA, USA.

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http://dx.doi.org/10.1111/bjh.16166DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6786919PMC
October 2019

More options for older patients with acute myeloid leukemia: venetoclax in combination with low dose cytarabine.

Chin Clin Oncol 2019 Oct;8(S1):S25

Gehr Family Center for Leukemia Research, Department of Hematology and Hematopoietic Cell Transplantation, City of Hope Medical Center, Duarte, CA, USA.

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http://dx.doi.org/10.21037/cco.2019.09.03DOI Listing
October 2019

The feasibility of venetoclax and decitabine in therapy-related acute myeloid leukemia with concurrent advanced non-hematological malignancies.

Leuk Res 2019 Sep 30;84:106196. Epub 2019 Jul 30.

Department of Hematology and Hematopoietic Cell Transplantation, Gehr Family Center for Leukemia Research, City of Hope, Duarte, CA, United States. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S01452126193014
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http://dx.doi.org/10.1016/j.leukres.2019.106196DOI Listing
September 2019

Influence of donor KIR genotypes on reduced relapse risk in acute myelogenous leukemia after hematopoietic stem cell transplantation in patients with CMV reactivation.

Leuk Res 2019 Sep 28;87:106230. Epub 2019 Sep 28.

Department of Hematology and Hematopoietic Cell Transplantation, City of Hope National Medical Center, Duarte, CA, United States.

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http://dx.doi.org/10.1016/j.leukres.2019.106230DOI Listing
September 2019

The Bcl-2 inhibitor venetoclax inhibits Nrf2 antioxidant pathway activation induced by hypomethylating agents in AML.

J Cell Physiol 2019 Aug 8;234(8):14040-14049. Epub 2019 Jan 8.

Gehr Family Center for Leukemia Research, Hematology Malignancies and Stem Cell Transplantation Institute, City of Hope Medical Center, Duarte, California.

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http://dx.doi.org/10.1002/jcp.28091DOI Listing
August 2019

Ebp1 p48 promotes oncogenic activities in human colon cancer cells through regulation of TIF-90-mediated ribosomal RNA synthesis.

J Cell Physiol 2019 Aug 22;234(10):17612-17621. Epub 2019 Feb 22.

Department of Medical Biotechnology, Biotechnology Center of Ho Chi Minh City, Ho Chi Minh City, Vietnam.

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http://dx.doi.org/10.1002/jcp.28385DOI Listing
August 2019

PRMT1-mediated FLT3 arginine methylation promotes maintenance of FLT3-ITD acute myeloid leukemia.

Blood 2019 Aug 19;134(6):548-560. Epub 2019 Jun 19.

Department of Hematological Malignancies Translational Science, Gehr Family Center for Leukemia Research, Hematologic Malignancies and Stem Cell Transplantation Institute, Beckman Research Institute, City of Hope Medical Center, Duarte, CA.

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http://dx.doi.org/10.1182/blood.2019001282DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6688430PMC
August 2019

Targeting cell membrane HDM2: A novel therapeutic approach for acute myeloid leukemia.

Leukemia 2019 Jul 23. Epub 2019 Jul 23.

Hematologic Malignancies Translational Science, Gehr Family Center for Leukemia Research, City of Hope Medical Center and Beckman Research Institute, Duarte, CA, USA.

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http://dx.doi.org/10.1038/s41375-019-0522-9DOI Listing
July 2019

Population pharmacokinetics of lenalidomide in patients with B-cell malignancies.

Br J Clin Pharmacol 2019 May 27;85(5):924-934. Epub 2019 Feb 27.

Australian Centre for Pharmacometrics, School of Pharmacy and Medical Sciences, Division of Health Sciences, University of South Australia, Australia.

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http://dx.doi.org/10.1111/bcp.13873DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6475687PMC
May 2019

Favorable outcomes for allogeneic hematopoietic cell transplantation in elderly patients with NPM1-mutated and FLT3-ITD-negative acute myeloid leukemia.

Bone Marrow Transplant 2019 May 14. Epub 2019 May 14.

Department of Hematology and Hematopoietic Cell Transplantation, Gehr Family Center for Leukemia Research, City of Hope, Duarte, CA, USA.

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http://dx.doi.org/10.1038/s41409-019-0553-xDOI Listing
May 2019

Hypomethylating agents in combination with venetoclax for acute myeloid leukemia: Update on clinical trial data and practical considerations for use.

Am J Hematol 2019 Mar 13;94(3):358-362. Epub 2018 Dec 13.

Department of Hematology and Hematopoietic Cell Transplantation, Gehr Family Center for Leukemia Research, City of Hope Medical Center, Duarte, California.

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http://doi.wiley.com/10.1002/ajh.25369
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http://dx.doi.org/10.1002/ajh.25369DOI Listing
March 2019

The emerging story of acute lymphoblastic leukemia among the Latin American population - biological and clinical implications.

Blood Rev 2019 01 14;33:98-105. Epub 2018 Aug 14.

University of Southern California, Los Angeles, CA, USA.

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http://dx.doi.org/10.1016/j.blre.2018.08.002DOI Listing
January 2019

Targeted Delivery of miRNA Antagonists to Myeloid Cells In Vitro and In Vivo.

Methods Mol Biol 2019 ;1974:141-150

Department of Immuno-Oncology, Beckman Research Institute at City of Hope, Duarte, CA, USA.

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http://dx.doi.org/10.1007/978-1-4939-9220-1_10DOI Listing
January 2019

The role of ErbB3 binding protein 1 in cancer: Friend or foe?

J Cell Physiol 2018 12 4;233(12):9110-9120. Epub 2018 Aug 4.

Department of Medical Biotechnology, Biotechnology Center of Ho Chi Minh City, Ho Chi Minh City, Vietnam.

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http://dx.doi.org/10.1002/jcp.26951DOI Listing
December 2018

SIRT1 Activation Disrupts Maintenance of Myelodysplastic Syndrome Stem and Progenitor Cells by Restoring TET2 Function.

Cell Stem Cell 2018 09 23;23(3):355-369.e9. Epub 2018 Aug 23.

Department of Hematological Malignancies Translational Science, Gehr Family Center for Leukemia Research, Hematologic Malignancies and Stem Cell Transplantation Institute, Beckman Research Institute, City of Hope Medical Center, Duarte, CA 91010, USA. Electronic address:

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http://dx.doi.org/10.1016/j.stem.2018.07.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6143172PMC
September 2018

Aging in a Relativistic Biological Space-Time.

Front Cell Dev Biol 2018 29;6:55. Epub 2018 May 29.

Division of Mathematical Oncology, City of Hope, National Medical Center, Duarte, CA, United States.

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http://dx.doi.org/10.3389/fcell.2018.00055DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5986934PMC
May 2018

R-2HG Exhibits Anti-tumor Activity by Targeting FTO/mA/MYC/CEBPA Signaling.

Cell 2018 01 14;172(1-2):90-105.e23. Epub 2017 Dec 14.

Department of Cancer Biology, University of Cincinnati, Cincinnati, OH 45219, USA; Gehr Family Center for Leukemia Research, City of Hope, 1500 E. Duarte Rd., Duarte, CA 91010, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2017.11.031DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5766423PMC
January 2018

HDAC8 regulates long-term hematopoietic stem-cell maintenance under stress by modulating p53 activity.

Blood 2017 12 30;130(24):2619-2630. Epub 2017 Oct 30.

Department of Hematological Malignancies Translational Science, Gehr Family Center for Leukemia Research, Hematologic Malignancies and Stem Cell Transplantation Institute, Beckman Research Institute, City of Hope Medical Center, Duarte, CA.

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http://dx.doi.org/10.1182/blood-2017-03-771386DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5731083PMC
December 2017

Correlates of resistance and relapse during blinatumomab therapy for relapsed/refractory acute lymphoblastic leukemia.

Am J Hematol 2017 Sep 5;92(9):858-865. Epub 2017 Jun 5.

Department of Hematology and Hematopoietic Cell Transplantation, Gehr Family Center for Leukemia Research, City of Hope Medical Center, Duarte, California.

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http://dx.doi.org/10.1002/ajh.24783DOI Listing
September 2017

Midostaurin plus Chemotherapy for Acute Myeloid Leukemia with a FLT3 Mutation.

N Engl J Med 2017 08 23;377(5):454-464. Epub 2017 Jun 23.

From the Department of Medical Oncology, Dana-Farber Cancer Institute, Boston (R.M.S.); the Division of Biomedical Statistics and Informatics (S.J.M., K.L.) and the Alliance Statistics and Data Center (S.J.M., K.L., S.G.), Mayo Clinic, Rochester, MN; the Alliance Statistics and Data Center, Duke University, Durham, NC (B.L.S.); the Ohio State University Comprehensive Cancer Center, Columbus (S.G., C.D.B., T.W.P., G.M., R.B.K.); Medizinische Klinik und Poliklinik I, Universitätsklinikum Carl Gustav Carus der TU Dresden, Dresden (C.T., G.E.), Department of Internal Medicine III, University Hospital of Ulm, Ulm (K.D., R.F.S., H.D.), Hematology and Oncology, University of Leipzig, Leipzig (D.N.), Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, Hannover (J.K., A.G.), and Department of Medicine II, Hematology-Oncology, Goethe University Hospital Frankfurt, Frankfurt am Main (H.S.) - all in Germany; the Department of Biomedicine and Prevention, University Tor Vergata, Rome (F.L.-C., S.A.); the Department of Clinical Haematology, Alfred Hospital and Monash University, Melbourne, VIC, Australia (A.W.); Hospital de la Santa Creu i Sant Pau, Hematology Department, Autonomous University of Barcelona, Barcelona (J.S.), and Hospital Universitario la Fe, Hematology Department, Department of Medicine, University of Valencia, Valencia (M.A.S.) - both in Spain; the Department of Medical Oncology and Hematology, Princess Margaret Hospital, Toronto (J.M.B.); Radboud Institute Molecular Studies, Radboud University Medical Center, Nijmegen, the Netherlands (T.W.); the Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle (F.R.A.); the Division of Hematology-Oncology, Stanford Comprehensive Cancer Center, Stanford University, Stanford, CA (B.C.M.); the Leukemia Service, Department of Medicine, Memorial Sloan Kettering Cancer Center and Weill Cornell Medical College, New York (M.S.T.); and the Department of Medicine, University of Chicago, Chicago (R.A.L.).

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http://dx.doi.org/10.1056/NEJMoa1614359DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5754190PMC
August 2017

Antileukemic activity and cellular effects of the antimalarial agent artesunate in acute myeloid leukemia.

Leuk Res 2017 08 10;59:124-135. Epub 2017 May 10.

Department of Hematology and Hematopoietic Cell Transplantation, City of Hope National Medical Center, Duarte, CA 91010, USA; Gehr Family Center for Leukemia Research City of Hope Medical Center, Duarte, CA 91010, USA. Electronic address:

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http://dx.doi.org/10.1016/j.leukres.2017.05.007DOI Listing
August 2017

Philadelphia chromosome as a recurrent event among therapy-related acute leukemia.

Am J Hematol 2017 Feb;92(2):E18-E19

Department of Hematology and Hematopoietic Cell Transplantation, Gehr Family Center for Leukemia Research, City of Hope, Duarte, California.

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http://dx.doi.org/10.1002/ajh.24604DOI Listing
February 2017

High Frequency and Poor Outcome of Philadelphia Chromosome-Like Acute Lymphoblastic Leukemia in Adults.

J Clin Oncol 2017 Feb 21;35(4):394-401. Epub 2016 Nov 21.

Kathryn G. Roberts, Zhaohui Gu, Debbie Payne-Turner, Kelly McCastlain, Deqing Pei, Ilaria Iacobucci, Marcus Valentine, Stanley B. Pounds, Lei Shi, Yongjin Li, Jinghui Zhang, Cheng Cheng, and Charles G. Mullighan, St Jude Children's Research Hospital, Memphis, TN; Richard C. Harvey, I-Ming Chen, and Cheryl L. Willman, University of New Mexico Cancer Center, Albuquerque, NM; Alessandro Rambaldi, Manuela Tosi, and Orietta Spinelli, Ospedale Papa Giovanni XXIII, Bergamo, Italy; Jerald P. Radich, Fred Hutchinson Cancer Research Center, Seattle, WA; Mark D. Minden, Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada; Jacob M. Rowe, Shaare Zedek Medical Center, Jerusalem, Israel; Selina Luger, Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA; Mark R. Litzow, Mayo Clinic, Rochester, MN; Martin S. Tallman, Memorial Sloan Kettering Cancer Center, Weill Cornell Medical College, New York; Peter H. Wiernik, Cancer Research Foundation of New York; Elisabeth Paietta, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY; Ravi Bhatia, The University of Alabama at Birmingham, Birmingham, AL; Ibrahim Aldoss and Guido Marcucci, City of Hope, Duarte, CA; Jessica Kohlschmidt, Krzysztof Mrózek, and Clara D. Bloomfield, Comprehensive Cancer Center, The Ohio State University, Columbus, OH; Wendy Stock, University of Chicago Medical Center, Chicago, IL; and Stephen Kornblau, Hagop M. Kantarjian, and Marina Konopleva, The University of Texas MD Anderson Cancer Center, Houston, TX.

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http://dx.doi.org/10.1200/JCO.2016.69.0073DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5455698PMC
February 2017

Identification of a CD133-CD55- population functions as a fetal common skeletal progenitor.

Sci Rep 2016 12 8;6:38632. Epub 2016 Dec 8.

Divison of Hematopoietic Stem Cell and Leukemia Research, Gehr Family Center for Leukemia Research, Beckman Research Institute of City of Hope, Duarte, CA 91010, USA.

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http://dx.doi.org/10.1038/srep38632DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5144148PMC
December 2016

Treatment of Acute Lymphoblastic Leukemia in Adults: Applying Lessons Learned in Children.

Oncology (Williston Park) 2016 12;30(12):1080-91

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December 2016

CCND1 mutations increase protein stability and promote ibrutinib resistance in mantle cell lymphoma.

Oncotarget 2016 Nov;7(45):73558-73572

Division of Hematopoietic Stem Cell and Leukemia Research, Gehr Leukemia Center, Beckman Research Institute of City of Hope, Duarte, CA 91010, USA.

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http://dx.doi.org/10.18632/oncotarget.12434DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5341999PMC
November 2016

Mechanism, Consequences, and Therapeutic Targeting of Abnormal IL15 Signaling in Cutaneous T-cell Lymphoma.

Cancer Discov 2016 09 15;6(9):986-1005. Epub 2016 Jul 15.

Comprehensive Cancer Center, James Cancer Hospital and Solove Research Institute, The Ohio State University, Columbus, Ohio. Division of Hematology, Department of Internal Medicine, The Ohio State University, Columbus, Ohio.

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http://dx.doi.org/10.1158/2159-8290.CD-15-1297DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5388135PMC
September 2016

CBFβ-SMMHC creates aberrant megakaryocyte-erythroid progenitors prone to leukemia initiation in mice.

Blood 2016 09 21;128(11):1503-15. Epub 2016 Jul 21.

Division of Hematopoietic Stem Cell and Leukemia Research, Gehr Family Center for Leukemia Research, Hematologic Malignancies and Stem Cell Transplantation Institute, Beckman Research Institute, City of Hope Medical Center, Duarte, CA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5025900PMC
http://dx.doi.org/10.1182/blood-2016-01-693119DOI Listing
September 2016

Cytogenetics Does Not Impact Outcomes in Adult Patients with Acute Lymphoblastic Leukemia Undergoing Allogeneic Hematopoietic Cell Transplantation.

Biol Blood Marrow Transplant 2016 07 1;22(7):1212-1217. Epub 2016 Apr 1.

Department of Hematology and Hematopoietic Cell Transplantation, City of Hope National Medical Center, Duarte, California. Electronic address:

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http://dx.doi.org/10.1016/j.bbmt.2016.03.025DOI Listing
July 2016

Induced Apoptosis Investigation in Wild-type and FLT3-ITD Acute Myeloid Leukemia Cells by Nanochannel Electroporation and Single-cell qRT-PCR.

Mol Ther 2016 05 19;24(5):956-64. Epub 2016 Jan 19.

NSF Nanoscale Science and Engineering Center for Affordable Nanoengineering of Polymeric Biomedical Devices, The Ohio State University, Columbus, Ohio, USA.

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http://dx.doi.org/10.1038/mt.2016.6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4881776PMC
May 2016

Acute Myeloid Leukemia: Biologic, Prognostic, and Therapeutic Insights.

Oncology (Williston Park) 2016 Apr;30(4):318-29

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April 2016

Not only TKI! Targeting FLT3-ITD by autophagy.

Blood 2016 Feb;127(7):796-7

CITY OF HOPE MEDICAL CENTER.

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http://dx.doi.org/10.1182/blood-2015-09-666560DOI Listing
February 2016

Nanochannel Electroporation as a Platform for Living Cell Interrogation in Acute Myeloid Leukemia.

Adv Sci (Weinh) 2015 12 16;2(12):1500111. Epub 2015 Jul 16.

Center for Affordable Nanoengineering of Polymeric Biomedical Devices The Ohio State University Columbus OH 43212 USA; William G. Lowrie, Department of Chemical and Biomolecular Engineering The Ohio State University Columbus OH 43210 USA.

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http://dx.doi.org/10.1002/advs.201500111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5115302PMC
December 2015

Preclinical Investigation of the Novel Histone Deacetylase Inhibitor AR-42 in the Treatment of Cancer-Induced Cachexia.

J Natl Cancer Inst 2015 Dec 12;107(12):djv274. Epub 2015 Oct 12.

Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy (YCT, SKK, ILL, ECH, CSC), Department of Molecular Virology, Immunology, and Medical Genetics (WAH, DCG), Department of Surgery (MB), Department of Internal Medicine (GBL, GM, TBS), and Center for Biostatistics (XM), College of Medicine, and Genomics Shared Resource (DEF, PSY), The Comprehensive Cancer Center, The Ohio State University, Columbus, OH; Institute of Basic Medical Sciences, National Cheng-Kung University, Tainan, Taiwan (CSC); Institute of Biological Chemistry, Academia Sinica, Taipei, Taiwan (CSC).

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http://jnci.oxfordjournals.org/content/107/12/djv274.full.pd
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http://jnci.oxfordjournals.org/lookup/doi/10.1093/jnci/djv27
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http://dx.doi.org/10.1093/jnci/djv274DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6280990PMC
December 2015

HDAC8 Inhibition Specifically Targets Inv(16) Acute Myeloid Leukemic Stem Cells by Restoring p53 Acetylation.

Cell Stem Cell 2015 Nov 18;17(5):597-610. Epub 2015 Sep 18.

Division of Hematopoietic Stem Cell and Leukemia Research, Beckman Research Institute, Norbert Gehr and Family Leukemia Center, City of Hope Medical Center, Duarte, CA 91010, USA. Electronic address:

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http://dx.doi.org/10.1016/j.stem.2015.08.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4636961PMC
November 2015

Promoter-Specific Hypomethylation Is Associated with Overexpression of PLS3, GATA6, and TWIST1 in the Sezary Syndrome.

J Invest Dermatol 2015 Aug 25;135(8):2084-2092. Epub 2015 Mar 25.

Division of Dermatology, Department of Internal Medicine, The Ohio State University, Columbus, Ohio, USA; The Comprehensive Cancer Center and The James Cancer Hospital and Solove Research Institute, The Ohio State University, Columbus, Ohio, USA; Division of Hematology, Department of Internal Medicine, The Ohio State University, Columbus, Ohio, USA; Department of Molecular Virology, Immunology and Medical Genetics, The Ohio State University, Columbus, Ohio, USA. Electronic address:

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http://dx.doi.org/10.1038/jid.2015.116DOI Listing
August 2015

CD33-Targeted Lipid Nanoparticles (aCD33LNs) for Therapeutic Delivery of GTI-2040 to Acute Myelogenous Leukemia.

Mol Pharm 2015 Jun 28;12(6):2010-8. Epub 2015 Apr 28.

†Division of Pharmaceutics, College of Pharmacy, ‡Division of Hematology-Oncology, §Molecular, Cellular and Developmental Biology Program, and ∥Department of Chemical and Biomolecular Engineering, The Ohio State University, Columbus, Ohio 43210, United States.

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http://dx.doi.org/10.1021/mp5008212DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4962870PMC
June 2015

Emerging diagnostic and therapeutic approaches in core binding factor acute myeloid leukaemia.

Curr Opin Hematol 2015 Mar;22(2):85-91

aUniversity of Minnesota, Department of Medicine, Division of Hematology, Oncology and Transplantation, Minneapolis, Minnesota bGehr Family Leukemia Center, City of Hope Comprehensive Cancer Center, Duarte, California, USA.

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http://dx.doi.org/10.1097/MOH.0000000000000124DOI Listing
March 2015

PrEMeR-CG: inferring nucleotide level DNA methylation values from MethylCap-seq data.

Bioinformatics 2014 Dec 31;30(24):3567-74. Epub 2014 Aug 31.

College of Medicine, Biomedical Sciences Graduate Program, Department of Internal Medicine, Division of Hematology, Department of Statistics, Mathematical Biosciences Institute, Department of Physics, Department of Chemistry & Biochemistry and Center for RNA Biology, The Ohio State University, Columbus, OH 43210, USA College of Medicine, Biomedical Sciences Graduate Program, Department of Internal Medicine, Division of Hematology, Department of Statistics, Mathematical Biosciences Institute, Department of Physics, Department of Chemistry & Biochemistry and Center for RNA Biology, The Ohio State University, Columbus, OH 43210, USA College of Medicine, Biomedical Sciences Graduate Program, Department of Internal Medicine, Division of Hematology, Department of Statistics, Mathematical Biosciences Institute, Department of Physics, Department of Chemistry & Biochemistry and Center for RNA Biology, The Ohio State University, Columbus, OH 43210, USA College of Medicine, Biomedical Sciences Graduate Program, Department of Internal Medicine, Division of Hematology, Department of Statistics, Mathematical Biosciences Institute, Department of Physics, Department of Chemistry & Biochemistry and Center for RNA Biology, The Ohio State University, Columbus, OH 43210, USA.

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http://dx.doi.org/10.1093/bioinformatics/btu583DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4253832PMC
December 2014

Targetable kinase-activating lesions in Ph-like acute lymphoblastic leukemia.

N Engl J Med 2014 Sep;371(11):1005-15

From the Departments of Pathology (K.G.R., D.P.-T., Y.-L.Y., K. McCastlain, G.S., J.M., S.-C.C., J.C., N.S.-M., I.I., J.W., J.R.D., C.G.M.), Computational Biology and Bioinformatics (Y.L., J.B., M.R., E.H., P.G., P.N., G.W., X.C., J.Z.), Biostatistics (D.P., C.C.), Pharmaceutical Sciences (S.W.P., M.V.R., W.E.E.), and Oncology (C.-H.P., S.J.), the Pediatric Cancer Genome Project (Y.L., L.D., C.L., M.R., J.E., J.C., K.B., R.S.F., E.H., P.G., P.N., G.W., X.C., D.Y., B.V., H.M., M.V.R., W.E.E., E.M., R.K.W., J.R.D., J.Z., C.G.M.), and Cytogenetics Shared Resource (M.V.), St. Jude Children's Research Hospital, Memphis, TN; the University of New Mexico Cancer Center and School of Medicine, Albuquerque (R.C.H., I-M.C., C.L.W.); the Genome Institute at Washington University (L.D., C.L., R.S.F., E.M., R.K.W.), the Department of Genetics, Washington University School of Medicine (L.D., C.L., R.S.F., E.M., R.K.W.), and Siteman Cancer Center, Washington University (E.M., R.K.W.) - all in St. Louis; Epidemiology and Health Policy Research, College of Medicine, University of Florida, Gainesville (M.D.); the Research Institute at Nationwide Children's Hospital (S.R., A.S., J.M.G.-F.), the Department of Pathology, College of Medicine, Ohio State University (N.A.H.), and Ohio State University Comprehensive Cancer Center (G.M., C.D.B., K. Mrózek, J.K.) - all in Columbus, OH; the Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas (N.J.W.), Scott and White Hospitals and Clinics and Texas A&M Health Science Center, Temple (G.G.), the University of Texas Health Science Center San Antonio, San Antonio (M.F.-J.), and the Departments of Leukemia and Stem Cell Transplantation, Division of Cancer Medicine, University of Texas M.D. Anderson Cancer Center, Houston (S.M.K., M.K.) - all in Texas; Maine Children's Cancer Program, Scarborough (E.C.L.); New York University Cancer Institute, New York (W.L.C.), and the Department of Medicine (Oncology), Albert Einstein

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http://dx.doi.org/10.1056/NEJMoa1403088DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4191900PMC
September 2014

Echinomycin protects mice against relapsed acute myeloid leukemia without adverse effect on hematopoietic stem cells.

Blood 2014 Aug 3;124(7):1127-35. Epub 2014 Jul 3.

Center for Cancer and Immunology Research, Children's Research Institute, Children's National Medical Center, Washington, DC;

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http://dx.doi.org/10.1182/blood-2013-12-544221DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4133485PMC
August 2014

Combined molecular and clinical prognostic index for relapse and survival in cytogenetically normal acute myeloid leukemia.

J Clin Oncol 2014 May 7;32(15):1586-94. Epub 2014 Apr 7.

Friederike Pastore, Annika Dufour, Tobias Benthaus, Klaus H. Metzeler, Stephanie Schneider, Bianka Ksienzyk, Gudrun Mellert, Evelyn Zellmeier, Purvi M. Kakadia, Michael Unterhalt, Wolfgang Hiddemann, Stefan K. Bohlander, Karsten Spiekermann, and Eva Hoster, University Hospital Munich Großhadern; Friederike Pastore, Klaus H. Metzeler, Wolfgang Hiddemann, Stefan K. Bohlander, and Karsten Spiekermann, Helmholtz Center Munich; Eva Hoster, University of Munich, Munich; Purvi M. Kakadia and Stefan K. Bohlander, University Hospital Marburg, Marburg; Michaela Feuring-Buske, University Hospital Ulm; Christian Buske, Comprehensive Cancer Center Ulm, University of Ulm, Ulm; Jan Braess, Klinikum Barmherzige Brüder, Regensburg; Maria Cristina Sauerland and Achim Heinecke, University of Muenster; Utz Krug, Wolfgang E. Berdel, and Thomas Buechner, University Hospital Muenster, Muenster; Bernhard Woermann, German Society of Hematology and Oncology, Berlin, Germany; Kati S. Maharry, Guido Marcucci, and Clara D. Bloomfield, The Ohio State University Comprehensive Cancer Center, Columbus, OH; Kati S. Maharry, Mayo Clinic, Rochester, MN; and Stefan K. Bohlander, University of Auckland, Auckland, New Zealand.

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http://jco.ascopubs.org/content/early/2014/04/03/JCO.2013.52
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http://jco.ascopubs.org/cgi/doi/10.1200/JCO.2013.52.3480
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http://dx.doi.org/10.1200/JCO.2013.52.3480DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4876345PMC
May 2014

Management of patients with cytogenetically normal acute myeloid leukemia who have neither favorable nor unfavorable markers.

J Natl Compr Canc Netw 2014 Apr;12(4):527-34

From the aDivision of Hematology, Department of Internal Medicine, and bDepartment of Molecular, Cellular, and Developmental Biology, The Ohio State University and The Ohio State Comprehensive Cancer Center, Columbus, Ohio.

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http://dx.doi.org/10.6004/jnccn.2014.0057DOI Listing
April 2014