Publications by authors named "Guido Koch"

27Publications

TOP-N53: A Clinical Drug Candidate for the Treatment of Non-healing Wounds.

Chimia (Aarau) 2020 Oct;74(10):814-817

Topadur Pharma AG, Grabenstrasse 11A, CH-8952 Schlieren, Switzerland.

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http://dx.doi.org/10.2533/chimia.2020.814DOI Listing
October 2020

Editorial.

Chimia (Aarau) 2020 Oct;74(10):749

Topadur Pharma AG.

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October 2020

Design of Potent and Selective Covalent Inhibitors of Bruton's Tyrosine Kinase Targeting an Inactive Conformation.

ACS Med Chem Lett 2019 Oct 6;10(10):1467-1472. Epub 2019 Sep 6.

Global Discovery Chemistry, Autoimmunity, Transplantation & Inflammation, Chemical Biology & Therapeutics, and PK Sciences, Novartis Institutes for BioMedical Research, Novartis Campus, CH-4002 Basel, Switzerland.

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http://dx.doi.org/10.1021/acsmedchemlett.9b00317DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6792172PMC
October 2019

Late-Stage Functionalization of Peptides and Cyclopeptides Using Organozinc Reagents.

Angew Chem Int Ed Engl 2019 06 9;58(24):8231-8234. Epub 2019 May 9.

Department Chemie, Ludwig-Maximilians-Universität München, Butenandtstrasse 5-13, Haus F, 81377, München, Germany.

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http://dx.doi.org/10.1002/anie.201902454DOI Listing
June 2019

Medicinal Chemistry.

Authors:
Guido Koch

Chimia (Aarau) 2017 Oct;71(10):643

Novartis Pharma AG Global Discovery Chemistry Director WKL-136.6.83 Novartis Pharma AG, Werk Klybeck Postfach CH-4002 Basel.

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October 2017

Synthesis of Bicyclo[1.1.1]pentane Bioisosteres of Internal Alkynes and para-Disubstituted Benzenes from [1.1.1]Propellane.

Angew Chem Int Ed Engl 2017 10 30;56(41):12774-12777. Epub 2017 Aug 30.

Ludwig-Maximilians-Universität München, Department Chemie, Butenandtstrasse 5-13, Haus F, 81377, München, Germany.

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http://dx.doi.org/10.1002/anie.201706799DOI Listing
October 2017

A segmented flow platform for on-demand medicinal chemistry and compound synthesis in oscillating droplets.

Chem Commun (Camb) 2017 Jun;53(49):6649-6652

Department of Chemical Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA.

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http://dx.doi.org/10.1039/c7cc03584eDOI Listing
June 2017

Improving Nonspecific Binding and Solubility: Bicycloalkyl Groups and Cubanes as para-Phenyl Bioisosteres.

ChemMedChem 2017 04 27;12(8):590-598. Epub 2017 Mar 27.

Global Discovery Chemistry, Novartis Institutes for BioMedical Research, 141 Klybeckstrasse, 4057, Basel, Switzerland.

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http://doi.wiley.com/10.1002/cmdc.201700082
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http://dx.doi.org/10.1002/cmdc.201700082DOI Listing
April 2017

Construction of a 3D-shaped, natural product like fragment library by fragmentation and diversification of natural products.

Bioorg Med Chem 2017 02 8;25(3):921-925. Epub 2016 Dec 8.

Novartis Institutes for BioMedical Research Inc., Basel, Switzerland. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S09680896163130
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http://dx.doi.org/10.1016/j.bmc.2016.12.005DOI Listing
February 2017

Multidimensional de novo design reveals 5-HT2B receptor-selective ligands.

Angew Chem Int Ed Engl 2015 Jan 4;54(5):1551-5. Epub 2014 Dec 4.

Department of Chemistry and Applied Biosciences, Swiss Federal Institute of Technology (ETH), Vladimir-Prelog-Weg 4, 8093 Zurich (Switzerland).

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http://dx.doi.org/10.1002/anie.201410201DOI Listing
January 2015

Rethinking leadership in drug discovery projects.

Drug Discov Today 2012 Dec 15;17(23-24):1258-62. Epub 2012 Jun 15.

ETH Zurich, Department of Management, Technology and Economics, Zurich, Switzerland.

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http://linkinghub.elsevier.com/retrieve/pii/S135964461200198
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http://dx.doi.org/10.1016/j.drudis.2012.06.005DOI Listing
December 2012

In vivo and in vitro SAR of tetracyclic MAPKAP-K2 (MK2) inhibitors. Part II.

Bioorg Med Chem Lett 2010 Aug 11;20(15):4719-23. Epub 2010 Apr 11.

Novartis Institutes for BioMedical Research, CH-4002 Basel, Switzerland.

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http://dx.doi.org/10.1016/j.bmcl.2010.04.023DOI Listing
August 2010

Novel 3-aminopyrazole inhibitors of MK-2 discovered by scaffold hopping strategy.

Bioorg Med Chem Lett 2010 Feb 3;20(3):1293-7. Epub 2009 Nov 3.

Novartis Institutes for BioMedical Research, CH-4002 Basel, Switzerland.

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http://dx.doi.org/10.1016/j.bmcl.2009.10.138DOI Listing
February 2010

Pyrrolo-pyrimidones: a novel class of MK2 inhibitors with potent cellular activity.

Bioorg Med Chem Lett 2008 Dec 11;18(23):6142-6. Epub 2008 Oct 11.

Novartis Institutes for BioMedical Research, global Discovery Chemistry, WSJ-88.508, CH-4002 Basel, Switzerland.

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http://dx.doi.org/10.1016/j.bmcl.2008.10.039DOI Listing
December 2008

Quality control in combinatorial chemistry: determinations of amounts and comparison of the "purity" of LC-MS-purified samples by NMR, LC-UV and CLND.

J Comb Chem 2005 May-Jun;7(3):364-71

Novartis Institutes for BioMedical Research, Lead Synthesis & Chemogenetics and Analytical & Imaging Sciences, CH-4002 Basel, Switzerland.

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http://dx.doi.org/10.1021/cc049850rDOI Listing
July 2005

N-H insertion reactions of primary ureas: the synthesis of highly substituted imidazolones and imidazoles from diazocarbonyls.

J Org Chem 2004 Dec;69(25):8829-35

Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.

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http://pubs.acs.org/doi/abs/10.1021/jo048353u
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http://dx.doi.org/10.1021/jo048353uDOI Listing
December 2004

N-h insertion reactions of Boc-amino acid amides: solution- and solid-phase synthesis of pyrazinones and pyrazines.

Org Lett 2004 Nov;6(24):4627-9

Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.

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http://pubs.acs.org/doi/abs/10.1021/ol047933a
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http://dx.doi.org/10.1021/ol047933aDOI Listing
November 2004

Smart cleavage reactions: the synthesis of an array of ureas from polymer-bound carbamates.

J Comb Chem 2004 Sep-Oct;6(5):822-7

Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA.

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http://pubs.acs.org/doi/abs/10.1021/cc049916i
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http://dx.doi.org/10.1021/cc049916iDOI Listing
January 2006

Solid-phase rhodium carbenoid N-H insertion reactions: the synthesis of a diverse array of indoles.

J Comb Chem 2003 Mar-Apr;5(2):188-96

The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA.

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http://dx.doi.org/10.1021/cc020079zDOI Listing
May 2003

Diastereoselective titanium enolate aldol reaction for the total synthesis of epothilones.

Org Lett 2002 Oct;4(22):3811-4

Novartis Pharma AG, Process R&D and BU Oncology, Postfach CH-4002 Basel, Switzerland.

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http://dx.doi.org/10.1021/ol026480bDOI Listing
October 2002

Rhodium carbenoid N-H insertion reactions of primary ureas: solution and solid-phase synthesis of imidazolones.

Org Lett 2003 Feb;5(4):511-4

Department of Chemistry, The Scripps Research Institute, 10550 N. Torrey Pines Road, La Jolla, California 92037, USA.

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http://pubs.acs.org/doi/abs/10.1021/ol020244j
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http://dx.doi.org/10.1021/ol020244jDOI Listing
February 2003

Stereoselective transformation of indole diazabicyclo[3.2.2]nonedione to azepinoindole.

Org Lett 2002 Dec;4(26):4709-12

Novartis Pharma AG, Core Technology, Combinatorial Chemistry Unit, WSJ-507.7.04 Lichtstrasse 35, CH-4056 Basel, Switzerland.

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http://dx.doi.org/10.1021/ol0271990DOI Listing
December 2002

Beta-aryl-succinic acid hydroxamates as dual inhibitors of matrix metalloproteinases and tumor necrosis factor alpha converting enzyme.

J Med Chem 2002 May;45(11):2289-93

Preclinical Research Novartis Pharma AG, CH-4002 Basel, Switzerland.

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http://dx.doi.org/10.1021/jm0110993DOI Listing
May 2002