Guenther Gastl

Guenther Gastl

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Guenther Gastl

Publications by authors named "Guenther Gastl"

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65Publications

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Treatment According to Molecular Profiling in Relapsed/Refractory Cancer Patients: A Review Focusing on Latest Profiling Studies.

Comput Struct Biotechnol J 2019 26;17:447-453. Epub 2019 Mar 26.

Department of Haematology and Oncology, Medical University of Innsbruck, Austria.

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http://dx.doi.org/10.1016/j.csbj.2019.03.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6453774PMC
March 2019

Harnessing the DNA Dye-triggered Side Population Phenotype to Detect and Purify Cancer Stem Cells from Biological Samples.

J Vis Exp 2017 05 10(123). Epub 2017 May 10.

Internal Medicine V, Medical University of Innsbruck; Tyrolean Cancer Research Institute (TKFI).

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http://dx.doi.org/10.3791/55634DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5607907PMC
May 2017

Heterogeneity of Cancer Stem Cells: Rationale for Targeting the Stem Cell Niche.

Biochim Biophys Acta 2016 12 15;1866(2):276-289. Epub 2016 Oct 15.

Internal Medicine V, Medical University of Innsbruck, Anichstrasse 35, 6020 Innsbruck, Austria; Tyrolean Cancer Research Institute (TKFI), Innrain 66, 6020 Innsbruck, Austria; Medical Clinic III, Oncology, Hematology, Immunoncology and Rheumatology, University Clinic Bonn (UKB), Sigmund-Freud-Strasse 25, 53127 Bonn, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.bbcan.2016.10.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5818142PMC
December 2016

Oncotyrol--Center for Personalized Cancer Medicine: Methods and Applications of Health Technology Assessment and Outcomes Research.

Z Evid Fortbild Qual Gesundhwes 2015 28;109(4-5):330-40. Epub 2015 Jul 28.

Internal Medicine V - Haematology and Oncology, Medical University of Innsbruck, Innsbruck, Austria.

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http://dx.doi.org/10.1016/j.zefq.2015.06.012DOI Listing
September 2016

Long-term treatment of hairy cell leukemia with interferon-α: still a viable therapeutic option.

Memo 2016;9:63-65. Epub 2016 Jun 17.

Department of Internal Medicine V, Medical University of Innsbruck, Anichstrasse 35, 6020 Innsbruck, Austria.

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http://dx.doi.org/10.1007/s12254-016-0269-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4923076PMC
June 2016

High prevalence of side population in human cancer cell lines.

Oncoscience 2016 10;3(3-4):85-87. Epub 2016 Apr 10.

Medical Clinic III, University Clinic Bonn (UKB), 53127 Bonn, Germany.

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http://dx.doi.org/10.18632/oncoscience.300DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4872646PMC
May 2016

Treg(s) in Cancer: Friends or Foe?

J Cell Physiol 2015 Nov;230(11):2598-605

Medical Clinic 3, Oncology, Hematology and Rheumatology, University Hospital Bonn (UKB), Bonn, Germany.

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http://dx.doi.org/10.1002/jcp.25016DOI Listing
November 2015

Ropeginterferon alfa-2b, a novel IFNα-2b, induces high response rates with low toxicity in patients with polycythemia vera.

Blood 2015 Oct 10;126(15):1762-9. Epub 2015 Aug 10.

Laboratory for Immunological and Molecular Cancer Research, Department of Internal Medicine III with Hematology, Medical Oncology, Hemostaseology, Infectious Diseases, Rheumatology, Oncologic Center, Paracelsus Medical University, Salzburg, Austria; and.

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http://dx.doi.org/10.1182/blood-2015-04-637280DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4608390PMC
October 2015

Drug Transporter-Mediated Protection of Cancer Stem Cells From Ionophore Antibiotics.

Stem Cells Transl Med 2015 Sep 1;4(9):1028-32. Epub 2015 Jul 1.

Tyrolean Cancer Research Institute, Innsbruck, Austria; Internal Medicine V and Medical Clinic III, Oncology, Hematology and Rheumatology, University Clinic Bonn, Bonn, Germany.

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http://dx.doi.org/10.5966/sctm.2015-0054DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4542876PMC
September 2015

Medical decision analysis for first-line therapy of chronic myeloid leukemia.

Leuk Lymphoma 2014 Aug 6;55(8):1758-67. Epub 2014 Feb 6.

Institute of Public Health, Medical Decision Making and Health Technology Assessment, Department of Public Health and Health Technology Assessment, UMIT - University for Health Sciences, Medical Informatics and Technology , Hall i.T. , Austria.

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http://dx.doi.org/10.3109/10428194.2013.858149DOI Listing
August 2014

The side population of ovarian cancer cells defines a heterogeneous compartment exhibiting stem cell characteristics.

Oncotarget 2014 Aug;5(16):7027-39

Internal Medicine V, Innsbruck Medical University, Innsbruck, Austria. Tyrolean Cancer Research Institute, Innsbruck, Austria. These authors contributed equally to this work.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4196181PMC
http://dx.doi.org/10.18632/oncotarget.2053DOI Listing
August 2014

Loss of membranous expression of the intracellular domain of EpCAM is a frequent event and predicts poor survival in patients with pancreatic cancer.

Histopathology 2014 Apr 2;64(5):683-92. Epub 2013 Dec 2.

Tyrolean Cancer Research Institute, Laboratory for Experimental Oncology, Innsbruck, Austria; Department of Internal Medicine V, Hematology and Oncology, Medical University Innsbruck, Innsbruck, Austria; Department of Hematology and Oncology, Franz Tappeiner Hospital, Merano, Italy; Oncotyrol-Center for Personalized Cancer Medicine, Innsbruck, Austria.

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http://dx.doi.org/10.1111/his.12307DOI Listing
April 2014

Systematic assessment of decision-analytic models for chronic myeloid leukemia.

Appl Health Econ Health Policy 2014 Apr;12(2):103-15

Division of Public Health Decision Modelling, Health Technology Assessment and Health Economics, ONCOTYROL-Center for Personalized Cancer Medicine, Innsbruck, Austria,

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http://dx.doi.org/10.1007/s40258-013-0071-8DOI Listing
April 2014

Low expression of junctional adhesion molecule A is associated with metastasis and poor survival in pancreatic cancer.

Ann Surg Oncol 2012 Dec 2;19(13):4330-6. Epub 2012 May 2.

Division of Hematology & Oncology, Medical University Innsbruck, Innsbruck, Austria.

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http://dx.doi.org/10.1245/s10434-012-2381-8DOI Listing
December 2012

Phenotype-dependent effects of EpCAM expression on growth and invasion of human breast cancer cell lines.

BMC Cancer 2012 Oct 30;12:501. Epub 2012 Oct 30.

Laboratory of Experimental Oncology, Tyrolean Cancer Research Institute, Innsbruck, Austria.

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http://bmccancer.biomedcentral.com/articles/10.1186/1471-240
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http://dx.doi.org/10.1186/1471-2407-12-501DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3519683PMC
October 2012

EpCAM expression in primary tumour tissues and metastases: an immunohistochemical analysis.

J Clin Pathol 2011 May 17;64(5):415-20. Epub 2011 Mar 17.

Laboratory for Experimental Oncology (Tyrolean Cancer Research Institute), Innsbruck Medical University, Innsbruck, Austria.

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http://dx.doi.org/10.1136/jcp.2011.090274DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3088404PMC
May 2011

Effects of EpCAM overexpression on human breast cancer cell lines.

BMC Cancer 2011 Jan 31;11:45. Epub 2011 Jan 31.

Laboratory for Experimental Oncology, Tyrolean Cancer Research Institute, Innrain 66, 6020 Innsbruck, Austria.

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http://dx.doi.org/10.1186/1471-2407-11-45DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3042418PMC
January 2011

GRP-78 secreted by tumor cells blocks the antiangiogenic activity of bortezomib.

Blood 2009 Oct 27;114(18):3960-7. Epub 2009 Aug 27.

Tumor Biology & Angiogenesis Laboratory, Department of Internal Medicine V, Innsbruck Medical University, Innsbruck, Austria.

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http://dx.doi.org/10.1182/blood-2009-03-209668DOI Listing
October 2009

The sphingosine 1-phosphate receptor agonist FTY720 potently inhibits regulatory T cell proliferation in vitro and in vivo.

J Immunol 2009 Sep 19;183(6):3751-60. Epub 2009 Aug 19.

Tyrolean Cancer Research Institute, Innsbruck Medical University, Innsbruck, Austria.

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http://dx.doi.org/10.4049/jimmunol.0901011DOI Listing
September 2009

Hodgkin lymphoma in Tyrol-a population-based study.

Ann Hematol 2009 May 10;88(5):449-56. Epub 2008 Oct 10.

Department of Hematology and Oncology, Innsbruck Medical University, Austria.

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http://dx.doi.org/10.1007/s00277-008-0618-1DOI Listing
May 2009

Possible role for gene expression profiling in predicting responses to conventional or targeted drugs in patients with chronic myeloid leukemia.

Leuk Lymphoma 2008 Apr;49(4):643-7

Department of Haematology and Oncology & Tyrolean Cancer Research Center, Medical University Innsbruck, Innsbruck, Austria.

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http://www.tandfonline.com/doi/full/10.1080/1042819080189619
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http://dx.doi.org/10.1080/10428190801896194DOI Listing
April 2008

TROP2: a novel prognostic marker in squamous cell carcinoma of the oral cavity.

Mod Pathol 2008 Feb 14;21(2):186-91. Epub 2007 Dec 14.

Department of Hematology and Oncology, Innsbruck Medical University, Innsbruck, Austria.

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http://dx.doi.org/10.1038/modpathol.3801001DOI Listing
February 2008

EpCAM expression in squamous cell carcinoma of the oral cavity: frequency and relationship to clinicopathologic features.

Oral Oncol 2008 Jan 5;44(1):72-7. Epub 2007 Apr 5.

Department of Craniomaxillofacial and Oral Surgery, Innsbruck Medical University, Anichstrasse 35 A-6020 Innsbruck, Austria.

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http://linkinghub.elsevier.com/retrieve/pii/S136883750700011
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http://dx.doi.org/10.1016/j.oraloncology.2007.01.008DOI Listing
January 2008

Knockdown of PgP resensitizes leukemic cells to proteasome inhibitors.

Biochem Biophys Res Commun 2007 Sep 23;361(2):549-54. Epub 2007 Jul 23.

Laboratory of Molecular Genetics, Department of Hematology and Oncology, Medical University Innsbruck, Innsbruck, Austria.

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http://dx.doi.org/10.1016/j.bbrc.2007.07.049DOI Listing
September 2007

Increased angiogenesis in chronic idiopathic myelofibrosis: vascular endothelial growth factor as a prominent angiogenic factor.

Hum Pathol 2007 Jul 18;38(7):1057-64. Epub 2007 Apr 18.

Division of Haematology and Oncology, Innsbruck Medical University, Innsbruck, Austria.

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http://dx.doi.org/10.1016/j.humpath.2006.12.011DOI Listing
July 2007

Methylation status of the Ep-CAM promoter region in human breast cancer cell lines and breast cancer tissue.

Cancer Lett 2007 Feb 18;246(1-2):253-61. Epub 2006 Apr 18.

Division of Haematology and Oncology, Innsbruck Medical University, Innsbruck, Austria.

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http://dx.doi.org/10.1016/j.canlet.2006.03.002DOI Listing
February 2007

Synergistic and additive antiproliferative effects on human leukemia cell lines induced by combining acetylenehexacarbonyldicobalt complexes with the tyrosine kinase inhibitor imatinib.

J Inorg Biochem 2006 Nov 4;100(11):1903-6. Epub 2006 Jul 4.

Institute of Pharmacy, Free University of Berlin, Koenigin-Luise-Strasse 2+4, 14195 Berlin, Germany.

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http://dx.doi.org/10.1016/j.jinorgbio.2006.06.013DOI Listing
November 2006

Telomere length of in vivo expanded CD4(+)CD25 (+) regulatory T-cells is preserved in cancer patients.

Cancer Immunol Immunother 2006 Oct 16;55(10):1198-208. Epub 2005 Dec 16.

Department of Hematology and Oncology, Innsbruck Medical University, Anichstr. 35, 6020 Innsbruck, Austria.

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http://dx.doi.org/10.1007/s00262-005-0107-5DOI Listing
October 2006

The effect of zoledronic acid on the function and differentiation of myeloid cells.

Haematologica 2006 Sep;91(9):1165-71

Laboratory of Tumorimmunology, Department of Hematology and Oncology, Innsbruck Medical University, Anichstr. 35, 6020 Innsbruck, Austria.

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September 2006

The expression of the regulatory T cell-specific forkhead box transcription factor FoxP3 is associated with poor prognosis in ovarian cancer.

Clin Cancer Res 2005 Dec;11(23):8326-31

Division of Hematology and Oncology, Department of Obstetrics and Gynecology, Innsbruck Medical University, Innsbruck, Austria.

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http://dx.doi.org/10.1158/1078-0432.CCR-05-1244DOI Listing
December 2005

The kinase inhibitor imatinib mesylate inhibits TNF-{alpha} production in vitro and prevents TNF-dependent acute hepatic inflammation.

Proc Natl Acad Sci U S A 2005 Sep 8;102(38):13622-7. Epub 2005 Sep 8.

Department of Gastroenterology and Hepatology, Innsbruck Medical University, 6020 Innsbruck, Austria.

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http://dx.doi.org/10.1073/pnas.0501758102DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1224614PMC
September 2005

RNAi-mediated knockdown of P-glycoprotein using a transposon-based vector system durably restores imatinib sensitivity in imatinib-resistant CML cell lines.

Exp Hematol 2005 Jul;33(7):767-75

Laboratory of Tumorbiology and Angiogenesis, Division of Hematology and Oncology, Medical University of Innsbruck, Austria.

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http://dx.doi.org/10.1016/j.exphem.2005.03.014DOI Listing
July 2005

CD4+CD25+ regulatory T cells inhibit experimental anti-glomerular basement membrane glomerulonephritis in mice.

J Am Soc Nephrol 2005 May 23;16(5):1360-70. Epub 2005 Mar 23.

Clinical Division of Hematology and Oncology, Innsbruck Medical University, Anichstrasse 35, 6020 Innsbruck, Austria.

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http://dx.doi.org/10.1681/ASN.2004100837DOI Listing
May 2005

Dendritic cells from patients with chronic myeloid leukemia: functional and phenotypic features.

Leuk Lymphoma 2005 May;46(5):663-70

Laboratory for Tumor and Immunobiology, Division of Hematology and Oncology, Innsbruck Medical University, Innsbruck, Austria.

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http://dx.doi.org/10.1080/10428190400029825DOI Listing
May 2005

Hodgkin's disease variant of Richter's syndrome in chronic lymphocytic leukaemia patients previously treated with fludarabine.

Br J Haematol 2005 Apr;129(2):199-205

Division of Haematology and Oncology, Innsbruck Medical University, Innsbruck, Austria.

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http://dx.doi.org/10.1111/j.1365-2141.2005.05426.xDOI Listing
April 2005

Increase of regulatory T cells in the peripheral blood of cancer patients.

Clin Cancer Res 2003 Feb;9(2):606-12

Institute for Biomedical Aging Research, Austrian Academy of Sciences, 6020 Innsbruck, Austria.

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February 2003

Phenotypic and functional deficiencies of leukaemic dendritic cells from patients with chronic myeloid leukaemia.

Br J Haematol 2003 Jan;120(1):63-73

Laboratory for Tumour and Immunobiology, Division of Haematology and Oncology, Innsbruck University Hospital, Innsbruck, Austria.

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http://dx.doi.org/10.1046/j.1365-2141.2003.03979.xDOI Listing
January 2003

Low concentrations of STI571 in the cerebrospinal fluid: a case report.

Br J Haematol 2002 Jun;117(3):623-5

Abteilung für Hämatologie & Onkologie, Universitätsklinik Innsbruck, Anichstrasse 35, A-6020 Innsbruck, Austria.

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http://dx.doi.org/10.1046/j.1365-2141.2002.03523.xDOI Listing
June 2002

Hepatosplenic gammadelta-T-cell lymphoma with leukemic course after renal transplantation.

Hum Pathol 2002 Feb;33(2):253-8

Division of Haematology and Oncology, University Hospital Innsbruck, Austria.

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http://dx.doi.org/10.1053/hupa.2002.31301DOI Listing
February 2002