Publications by authors named "Guenter Schwarz"

55Publications

The role of glutamate oxaloacetate transaminases in sulfite biosynthesis and HS metabolism.

Redox Biol 2021 Jan 24;38:101800. Epub 2020 Nov 24.

Institute for Biochemistry, Department of Chemistry, University of Cologne, Cologne, Germany; Center for Molecular Medicine, University of Cologne, Cologne, Germany. Electronic address:

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January 2021

Molybdenum cofactor biology, evolution and deficiency.

Biochim Biophys Acta Mol Cell Res 2021 Jan 2;1868(1):118883. Epub 2020 Oct 2.

Institute of Biochemistry, Department of Chemistry, Center for Molecular Medicine, University of Cologne, Zuelpicher Str. 47, 50674 Koeln, Germany. Electronic address:

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January 2021

Alternative splicing of the bicistronic gene molybdenum cofactor synthesis 1 () uncovers a novel mitochondrial protein maturation mechanism.

J Biol Chem 2020 03 29;295(10):3029-3039. Epub 2020 Jan 29.

Institute of Biochemistry, Department of Chemistry, University of Cologne, 50674 Cologne, Germany

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March 2020

Oxygen and nitrite reduction by heme-deficient sulphite oxidase in a patient with mild sulphite oxidase deficiency.

J Inherit Metab Dis 2020 07 27;43(4):748-757. Epub 2020 Jan 27.

Institute for Biochemistry, Department of Chemistry, University of Cologne, Cologne, Germany.

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July 2020

Mechanism of nitrite-dependent NO synthesis by human sulfite oxidase.

Biochem J 2019 06 28;476(12):1805-1815. Epub 2019 Jun 28.

Department of Chemistry, Institute for Biochemistry, University of Cologne, 50674 Cologne, Germany

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June 2019

Reciprocal regulation of sulfite oxidation and nitrite reduction by mitochondrial sulfite oxidase.

Nitric Oxide 2019 08 17;89:22-31. Epub 2019 Apr 17.

Institute of Biochemistry, Department of Chemistry, University of Cologne, Cologne, 50674, Germany; Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, 50931, Germany. Electronic address:

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August 2019

Homeostatic impact of sulfite and hydrogen sulfide on cysteine catabolism.

Br J Pharmacol 2019 02 27;176(4):554-570. Epub 2018 Sep 27.

Institute of Biochemistry, Department of Chemistry and Center for Molecular Medicine Cologne, University of Cologne, Cologne, Germany.

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February 2019

Nitrite-dependent nitric oxide synthesis by molybdenum enzymes.

FEBS Lett 2018 06 27;592(12):2126-2139. Epub 2018 May 27.

Department of Chemistry, Institute for Biochemistry, University of Cologne, Germany.

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June 2018

Sequences Flanking the Gephyrin-Binding Site of GlyRβ Tune Receptor Stabilization at Synapses.

eNeuro 2018 Jan-Feb;5(1). Epub 2018 Feb 19.

Department of Chemistry, Institute of Biochemistry, University of Cologne, Cologne 50674, Germany.

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January 2019

Molybdenum cofactor deficiency type A: Prenatal monitoring using MRI.

Eur J Paediatr Neurol 2018 May 28;22(3):536-540. Epub 2017 Nov 28.

Section of Metabolic Diseases, Beatrix Children's Hospital, University Medical Center Groningen, University of Groningen, PO Box 30.001, 9700 RB Groningen, the Netherlands. Electronic address:

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May 2018

Chitosan-Promoted Direct Electrochemistry of Human Sulfite Oxidase.

J Phys Chem B 2017 10 21;121(39):9149-9159. Epub 2017 Sep 21.

School of Chemistry and Molecular Biosciences, University of Queensland , Brisbane, 4072, Australia.

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October 2017

Vaginal prolapse with urinary bladder incarceration and consecutive irreducible rectal prolapse in a dog.

Acta Vet Scand 2016 Sep 22;58(1):54. Epub 2016 Sep 22.

Department of Surgery, University of Agricultural Sciences and Veterinary Medicine, 3-5 Mănăştur Street, 400372, Cluj-Napoca, Romania.

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September 2016

Molybdenum cofactor and human disease.

Authors:
Guenter Schwarz

Curr Opin Chem Biol 2016 04 4;31:179-87. Epub 2016 Apr 4.

Institute of Biochemistry, Department of Chemistry and Center for Molecular Medicine Cologne and Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases, University of Cologne, Zuelpicher Str. 47, 50674 Koeln, Germany. Electronic address:

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April 2016

Erratum to: Structure and stability of the molybdenum cofactor intermediate cyclic pyranopterin monophosphate.

J Biol Inorg Chem 2016 Apr;21(2):293

Institute of Biochemistry, Department of Chemistry & Center for Molecular Medicine Cologne, University of Cologne, 50674, Cologne, Germany.

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April 2016

Simultaneous impairment of neuronal and metabolic function of mutated gephyrin in a patient with epileptic encephalopathy.

EMBO Mol Med 2015 Dec;7(12):1580-94

Department of Chemistry, Institute of Biochemistry University of Cologne, Cologne, Germany Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD) University of Cologne, Cologne, Germany

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December 2015

Oxygen reactivity of mammalian sulfite oxidase provides a concept for the treatment of sulfite oxidase deficiency.

Biochem J 2015 Jul;469(2):211-21

Institute of Biochemistry, Department of Chemistry, Center for Molecular Medicine Cologne (CMMC) and Cologne Excellence Cluster on Cellular Stress Responses in Ageing-Associated Diseases (CECAD), University of Cologne, Zuelpicher Straße 47, 50674 Cologne, Germany

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July 2015

Modified amelogenin is a new and versatile nanomaterial for biomedical applications.

Biotechnol Bioeng 2015 Aug 12;112(8):1708-13. Epub 2015 May 12.

Institute for Dental Research and Oral Musculoskeletal Biology, Center for Biochemistry, Medical Faculty, University of Cologne, Kerpener-Str. 32, Cologne, 50931, Germany.

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August 2015

Investigation of molybdenum cofactor deficiency due to MOCS2 deficiency in a newborn baby.

Meta Gene 2015 Feb 31;3:43-9. Epub 2015 Jan 31.

Department of Paediatrics, Campbelltown Hospital, Campbelltown, NSW, Australia ; Department of Paediatrics, School of Medicine, University of Western Sydney, Campbelltown, NSW, Australia.

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February 2015

Dual binding of 14-3-3 protein regulates Arabidopsis nitrate reductase activity.

J Biol Inorg Chem 2015 Mar 13;20(2):277-86. Epub 2015 Jan 13.

Department of Chemistry, Institute for Biochemistry, University of Cologne, 50674, Cologne, Germany.

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March 2015

Involvement of the Cys-Tyr cofactor on iron binding in the active site of human cysteine dioxygenase.

Amino Acids 2015 Jan 27;47(1):55-63. Epub 2014 Sep 27.

Department of Chemistry, Institute of Biochemistry, University of Cologne, 50674, Cologne, Germany.

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January 2015

Palmitoylation of gephyrin controls receptor clustering and plasticity of GABAergic synapses.

PLoS Biol 2014 Jul 15;12(7):e1001908. Epub 2014 Jul 15.

Institute of Biochemistry, Department of Chemistry, University of Cologne, Cologne, Germany; Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany; Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany.

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July 2014

Neuronal nitric oxide synthase-dependent S-nitrosylation of gephyrin regulates gephyrin clustering at GABAergic synapses.

J Neurosci 2014 Jun;34(23):7763-8

Department of Chemistry, Institute of Biochemistry, Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases, and Center for Molecular Medicine, University of Cologne, 50674 Cologne, Germany

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June 2014

Molybdenum in human health and disease.

Met Ions Life Sci 2013 ;13:415-50

Institute of Biochemistry, Department of Chemistry, Center for Molecular Medicine, University of Cologne, Zülpicher Strasse 47, D-50674, Köln, Germany,

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June 2014

Structural basis of thermal stability of the tungsten cofactor synthesis protein MoaB from Pyrococcus furiosus.

PLoS One 2014 20;9(1):e86030. Epub 2014 Jan 20.

Institute of Biochemistry, Department of Chemistry, University of Cologne, Cologne, Germany ; Cluster of Excellence in Cellular Stress Responses in Aging-associated Diseases (CECAD), University of Cologne, Cologne, Germany ; Center for Molecular Medicine Cologne, University of Cologne, Cologne, Germany.

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January 2015

Low-molecular weight heparin increases circulating sFlt-1 levels and enhances urinary elimination.

PLoS One 2014 21;9(1):e85258. Epub 2014 Jan 21.

Division of Nephrology, Department of Internal Medicine and Center for Molecular Medicine, University of Cologne, Cologne, Germany.

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October 2014

Molybdenum cofactor deficiency: a new HPLC method for fast quantification of s-sulfocysteine in urine and serum.

JIMD Rep 2012 17;5:35-43. Epub 2011 Dec 17.

Institute of Biochemistry, Department of Chemistry and Center for Molecular Medicine Cologne, University of Cologne, Zuelpicher Str. 47, 50674, Cologne, Germany.

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February 2013

Molybdenum cofactor deficiency: metabolic link between taurine and S-sulfocysteine.

Adv Exp Med Biol 2013 ;776:13-9

Department of Chemistry and Center for Molecular Medicine Cologne, University of Cologne, Cologne, Germany.

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June 2013

Direct binding of GABAA receptor β2 and β3 subunits to gephyrin.

Eur J Neurosci 2013 Feb 4;37(4):544-54. Epub 2012 Dec 4.

Department of Chemistry, Institute of Biochemistry, University of Cologne, Cologne, Germany.

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February 2013

Metal insertion into the molybdenum cofactor: product-substrate channelling demonstrates the functional origin of domain fusion in gephyrin.

Biochem J 2013 Feb;450(1):149-57

Institute of Biochemistry, Department of Chemistry and Center for Molecular Medicine Cologne, University of Cologne, Zuelpicher Str. 47, 50674, Cologne, Germany.

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February 2013

The mitochondrial amidoxime-reducing component (mARC1) is a novel signal-anchored protein of the outer mitochondrial membrane.

J Biol Chem 2012 Dec 19;287(51):42795-803. Epub 2012 Oct 19.

Institute of Biochemistry, Department of Chemistry and Center for Molecular Medicine, University of Cologne, 50674 Cologne, Germany.

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December 2012

Favorable outcome in a newborn with molybdenum cofactor type A deficiency treated with cPMP.

Pediatrics 2012 Oct 17;130(4):e1005-10. Epub 2012 Sep 17.

Division of Metabolic Diseases, Department of Pediatrics, Beatrix Children's Hospital, University Medical Center Groningen, University of Groningen, Groningen, Netherlands.

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October 2012

Cofactor-dependent maturation of mammalian sulfite oxidase links two mitochondrial import pathways.

J Cell Sci 2012 Oct 1;125(Pt 20):4876-85. Epub 2012 Aug 1.

Institut für Biochemie, Department Chemie und Zentrum für Molekulare Medizin Köln, Universität zu Köln, Germany.

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October 2012

Splice-specific glycine receptor binding, folding, and phosphorylation of the scaffolding protein gephyrin.

J Biol Chem 2012 Apr 17;287(16):12645-56. Epub 2012 Feb 17.

Institute of Biochemistry, Department of Chemistry and Center for Molecular Medicine, University of Cologne, 50674 Cologne, Germany.

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April 2012

Molecular mechanism of 14-3-3 protein-mediated inhibition of plant nitrate reductase.

J Biol Chem 2012 Feb 13;287(7):4562-71. Epub 2011 Dec 13.

Institute of Biochemistry, Department of Chemistry and Center for Molecular Medicine, University of Cologne, 50674 Cologne, Germany.

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February 2012

Structure and stability of the molybdenum cofactor intermediate cyclic pyranopterin monophosphate.

J Biol Inorg Chem 2012 Jan 30;17(1):113-22. Epub 2011 Aug 30.

Institute of Biochemistry, Department of Chemistry & Center for Molecular Medicine Cologne, University of Cologne, 50674 Cologne, Germany.

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January 2012

A molecular basis for tungstate selectivity in prokaryotic ABC transport systems.

J Bacteriol 2011 Sep 22;193(18):4999-5001. Epub 2011 Jul 22.

Department of Biotechnology, Delft University of Technology, Julianalaan 67, 2628 BC Delft, The Netherlands.

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September 2011

Kinetic analysis of 14-3-3-inhibited Arabidopsis thaliana nitrate reductase.

Biochemistry 2010 Sep;49(37):8177-86

Institute of Biochemistry, Department of Chemistry, University of Cologne, 50674 Cologne, Germany.

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September 2010

Splice-specific functions of gephyrin in molybdenum cofactor biosynthesis.

J Biol Chem 2008 Jun 14;283(25):17370-9. Epub 2008 Apr 14.

Institute of Biochemistry and Center for Molecular Medicine, University of Cologne, 50674 Cologne, Germany.

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June 2008

Function of MoaB proteins in the biosynthesis of the molybdenum and tungsten cofactors.

Biochemistry 2008 Jan 22;47(3):949-56. Epub 2007 Dec 22.

Department of Biotechnology, Delft University of Technology, Delft, the Netherlands.

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January 2008

Chlamydomonas reinhardtii CNX1E reconstitutes molybdenum cofactor biosynthesis in Escherichia coli mutants.

Eukaryot Cell 2007 Jun 6;6(6):1063-7. Epub 2007 Apr 6.

Departamento de Bioquímica y Biología Molecular, Facultad de Ciencias, Universidad de Córdoba, Campus de Rabanales, Edificio Severo Ochoa, 14071 Córdoba, Spain.

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June 2007

Function and structure of the molybdenum cofactor carrier protein from Chlamydomonas reinhardtii.

J Biol Chem 2006 Oct 27;281(40):30186-94. Epub 2006 Jul 27.

Institute of Plant Biology, Technical University Braunschweig, 38106 Braunschweig, Germany.

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October 2006

The Mechanism of nucleotide-assisted molybdenum insertion into molybdopterin. A novel route toward metal cofactor assembly.

J Biol Chem 2006 Jul 24;281(27):18343-50. Epub 2006 Apr 24.

Institute of Plant Biology, Technical University Braunschweig, 38106 Braunschweig, Germany.

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July 2006

Structural basis of eukaryotic nitrate reduction: crystal structures of the nitrate reductase active site.

Plant Cell 2005 Apr 16;17(4):1167-79. Epub 2005 Mar 16.

Institute of Plant Biology, Technical University Braunschweig, D-38106 Braunschweig, Germany.

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April 2005