Guangwei Du

Guangwei Du

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Guangwei Du

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Phosphatidic acid generated by PLD2 promotes the plasma membrane recruitment of IQGAP1 and neointima formation.

FASEB J 2019 Jun 27;33(6):6713-6725. Epub 2019 Feb 27.

Department of Integrative Biology and Pharmacology, The University of Texas Health Science Center at Houston, Houston, Texas, USA.

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http://dx.doi.org/10.1096/fj.201800390RRDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6529346PMC
June 2019

Higher Hippocampal Mean Diffusivity Values in Asymptomatic Welders.

Toxicol Sci 2019 Apr;168(2):486-496

Department of Neurology, Milton S. Hershey Medical Center, Pennsylvania State University, Hershey, Pennsylvania 17033.

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https://academic.oup.com/toxsci/advance-article/doi/10.1093/
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http://dx.doi.org/10.1093/toxsci/kfz011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6432863PMC
April 2019

Multimodal MRI evaluation of parkinsonian limbic pathologies.

Neurobiol Aging 2019 04 16;76:194-200. Epub 2019 Jan 16.

Department of Neurology, Pennsylvania State University-Milton S. Hershey Medical Center, Hershey, PA, USA; Department of Pharmacology, Pennsylvania State University-Milton S. Hershey Medical Center, Hershey, PA, USA; Department of Radiology, Pennsylvania State University-Milton S. Hershey Medical Center, Hershey, PA, USA; Department of Neurosurgery, Pennsylvania State University-Milton S. Hershey Medical Center, Hershey, PA, USA; Department of Kinesiology, Penn State University-Milton S. Hershey Medical Center, Hershey, PA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neurobiolaging.2019.01.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6461740PMC
April 2019

Brain cholesterol metabolism and Parkinson's disease.

Mov Disord 2019 03 25;34(3):386-395. Epub 2019 Jan 25.

Department of Neurology, Pennsylvania State University, Hershey, Pennsylvania, USA.

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http://dx.doi.org/10.1002/mds.27609DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6420391PMC
March 2019

PLD-dependent phosphatidic acid microdomains are signaling platforms for podosome formation.

Sci Rep 2019 Mar 5;9(1):3556. Epub 2019 Mar 5.

Department of Cell Biology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1038/s41598-019-39358-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6401089PMC
March 2019

Bile acids target proteolipid nano-assemblies of EGFR and phosphatidic acid in the plasma membrane for stimulation of MAPK signaling.

PLoS One 2018 31;13(8):e0198983. Epub 2018 Aug 31.

Department of Integrative Biology and Pharmacology, University of Texas Health Science Center, Houston, Texas, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0198983PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6118352PMC
January 2019

Magnetic resonance T1w/T2w ratio: A parsimonious marker for Parkinson disease.

Ann Neurol 2019 Jan 19;85(1):96-104. Epub 2018 Dec 19.

Department of Neurology, Penn State Hershey Medical Center, Hershey, PA.

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http://dx.doi.org/10.1002/ana.25376DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6342624PMC
January 2019

Susceptibility MRI captures nigral pathology in patients with parkinsonian syndromes.

Mov Disord 2018 09 14;33(9):1432-1439. Epub 2018 May 14.

Departments of Neurology, Pennsylvania State University-Milton S. Hershey Medical Center, Hershey, Pennsylvania, USA.

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http://doi.wiley.com/10.1002/mds.27381
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http://dx.doi.org/10.1002/mds.27381DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6185787PMC
September 2018

Distinct progression pattern of susceptibility MRI in the substantia nigra of Parkinson's patients.

Mov Disord 2018 09 14;33(9):1423-1431. Epub 2018 May 14.

Department of Neurology, Penn State University-Milton S. Hershey Medical Center, Hershey, Pennsylvania, United States.

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http://dx.doi.org/10.1002/mds.27318DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6185755PMC
September 2018

Interior regularity of obstacle problems for nonlinear subelliptic systems with VMO coefficients.

J Inequal Appl 2018 5;2018(1):53. Epub 2018 Mar 5.

School of Mathematical Sciences, Qufu Normal University, Qufu, China.

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http://dx.doi.org/10.1186/s13660-018-1647-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5838259PMC
March 2018

Small molecule metabolite biomarkers for hepatocellular carcinoma with bile duct tumor thrombus diagnosis.

Sci Rep 2018 02 19;8(1):3309. Epub 2018 Feb 19.

Department of Biliary surgery, Eastern Hepatobiliary Surgery Hospital, The Second Military Medical University, Shanghai, 200438, China.

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http://dx.doi.org/10.1038/s41598-018-21595-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5818651PMC
February 2018

Binding of PLD2-Generated Phosphatidic Acid to KIF5B Promotes MT1-MMP Surface Trafficking and Lung Metastasis of Mouse Breast Cancer Cells.

Dev Cell 2017 10 12;43(2):186-197.e7. Epub 2017 Oct 12.

Department of Integrative Biology and Pharmacology, University of Texas Health Science Center at Houston, 6431 Fannin St., Houston, TX 77030, USA. Electronic address:

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http://dx.doi.org/10.1016/j.devcel.2017.09.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5663201PMC
October 2017

Predicting the multi-domain progression of Parkinson's disease: a Bayesian multivariate generalized linear mixed-effect model.

BMC Med Res Methodol 2017 Sep 25;17(1):147. Epub 2017 Sep 25.

Department of Neurology, Pennsylvania State University Hershey Medical Center, Hershey, PA, 17033, USA.

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http://dx.doi.org/10.1186/s12874-017-0415-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5613469PMC
September 2017

Circulating Cholesterol Levels May Link to the Factors Influencing Parkinson's Risk.

Front Neurol 2017 27;8:501. Epub 2017 Sep 27.

Department of Neurology, Pennsylvania State University College of Medicine-Milton S. Hershey Medical Center, Hershey, PA, United States.

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http://dx.doi.org/10.3389/fneur.2017.00501DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5624032PMC
September 2017

The VPS34 PI3K negatively regulates RAB-5 during endosome maturation.

J Cell Sci 2017 Jun 28;130(12):2007-2017. Epub 2017 Apr 28.

Division of Endocrinology and Metabolism, Departments of Medicine, and Anatomy and Cell Biology, McGill University, and the Program in Metabolic Disorders and Complications, Centre for Translational Biology, Research Institute of the McGill University Health Centre, Montreal, Quebec, Canada H4A 3J1

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http://dx.doi.org/10.1242/jcs.194746DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5482978PMC
June 2017

Microbial Genetic Composition Tunes Host Longevity.

Cell 2017 Jun;169(7):1249-1262.e13

Huffington Center on Aging, Baylor College of Medicine, Houston, TX 77030, USA; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA; Dan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, TX 77030, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2017.05.036DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5635830PMC
June 2017

Cortical gray and subcortical white matter associations in Parkinson's disease.

Neurobiol Aging 2017 01 28;49:100-108. Epub 2016 Sep 28.

Department of Neurology, Pennsylvania State University-Milton S. Hershey Medical Center, Hershey, PA, USA; Department of Pharmacology, Pennsylvania State University-Milton S. Hershey Medical Center, Hershey, PA, USA; Department of Radiology, Pennsylvania State University-Milton S. Hershey Medical Center, Hershey, PA, USA; Department of Neurosurgery, Pennsylvania State University-Milton S. Hershey Medical Center, Hershey, PA, USA; Department of Kinesiology, Pennsylvania State University-Milton S. Hershey Medical Center, Hershey, PA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neurobiolaging.2016.09.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5154847PMC
January 2017

Association of neurobehavioral performance with R2* in the caudate nucleus of asymptomatic welders.

Neurotoxicology 2017 01 18;58:66-74. Epub 2016 Nov 18.

Department of Neurology, The Pennsylvania State University-Milton S. Hershey Medical Center, Hershey PA 17033, USA; Department of Pharmacology, The Pennsylvania State University-Milton S. Hershey Medical Center, Hershey PA 17033, USA; Department of Radiology, The Pennsylvania State University-Milton S. Hershey Medical Center, Hershey PA 17033, USA; Department of Neurosurgery, The Pennsylvania State University-Milton S. Hershey Medical Center, Hershey PA 17033, USA; Department of Kinesiology, The Pennsylvania State University-Milton S. Hershey Medical Center, Hershey PA 17033, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S0161813X163024
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http://dx.doi.org/10.1016/j.neuro.2016.11.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5729887PMC
January 2017

Longitudinal T1 relaxation rate (R1) captures changes in short-term Mn exposure in welders.

Neurotoxicology 2016 12 24;57:39-44. Epub 2016 Aug 24.

Department of Neurology, Pennsylvania State University College of Medicine-Milton S. Hershey Medical Center, Hershey, PA, USA; Department of Pharmacology, Pennsylvania State University College of Medicine-Milton S. Hershey Medical Center, Hershey, PA, USA; Departments of Radiology, Pennsylvania State University College of Medicine-Milton S. Hershey Medical Center, Hershey, PA, USA; Department of Kinesiology, Pennsylvania State University, University Park, PA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neuro.2016.08.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5123898PMC
December 2016

Phospholipase D1-regulated autophagy supplies free fatty acids to counter nutrient stress in cancer cells.

Cell Death Dis 2016 11 3;7(11):e2448. Epub 2016 Nov 3.

Department of Integrative Biology and Pharmacology, University of Texas Health Science Center at Houston, Houston, TX 77030, USA.

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http://dx.doi.org/10.1038/cddis.2016.355DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5260880PMC
November 2016

Inhibition of Epac1 suppresses mitochondrial fission and reduces neointima formation induced by vascular injury.

Sci Rep 2016 11 10;6:36552. Epub 2016 Nov 10.

Department of Integrative Biology and Pharmacology, The University of Texas Health Science Center, Houston, Texas, USA.

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http://www.nature.com/articles/srep36552
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http://dx.doi.org/10.1038/srep36552DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5103196PMC
November 2016

Analysis of Invadopodia Formation in Breast Cancer Cells.

Methods Mol Biol 2016 ;1406:203-10

Department of Integrative Biology and Pharmacology, The University of Texas Health Science Center at Houston, 6431 Fannin St, Houston, TX, 77030, USA.

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http://dx.doi.org/10.1007/978-1-4939-3444-7_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5152756PMC
October 2016

Monitoring Phosphatidic Acid Signaling in Breast Cancer Cells Using Genetically Encoded Biosensors.

Methods Mol Biol 2016 ;1406:225-37

Department of Integrative Biology and Pharmacology, The University of Texas Health Science Center at Houston, 6431 Fannin St, Houston, TX, 77030, USA.

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http://dx.doi.org/10.1007/978-1-4939-3444-7_20DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5152759PMC
October 2016

Synergy as a new and sensitive marker of basal ganglia dysfunction: A study of asymptomatic welders.

Neurotoxicology 2016 09 30;56:76-85. Epub 2016 Jun 30.

Department of Neurology, Pennsylvania State University-Milton S. Hershey Medical Center, Hershey, PA 17033, United States; Department of Pharmacology, Pennsylvania State University-Milton S. Hershey Medical Center, Hershey, PA 17033, United States; Department of Radiology, Pennsylvania State University-Milton S. Hershey Medical Center, Hershey, PA 17033, United States; Department of Neurosurgery, Pennsylvania State University-Milton S. Hershey Medical Center, Hershey, PA 17033, United States; Department of Kinesiology, The Pennsylvania State University, University Park, PA 16802, United States. Electronic address:

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http://dx.doi.org/10.1016/j.neuro.2016.06.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5729892PMC
September 2016

Editor's Highlight: Lower Fractional Anisotropy in the Globus Pallidus of Asymptomatic Welders, a Marker for Long-Term Welding Exposure.

Toxicol Sci 2016 09 27;153(1):165-73. Epub 2016 Jul 27.

*Department of Neurology, Pennsylvania State University-Milton S. Hershey Medical Center, Hershey, Pennsylvania 17033; Department of Pharmacology, Pennsylvania State University-Milton S. Hershey Medical Center, Hershey, Pennsylvania 17033; Department of Radiology; Department of Neurosurgery; Department of Kinesiology, Pennsylvania State University-Milton S. Hershey Medical Center, Hershey, Pennsylvania 17033

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http://dx.doi.org/10.1093/toxsci/kfw116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5013881PMC
September 2016

Folded concave penalized learning in identifying multimodal MRI marker for Parkinson's disease.

J Neurosci Methods 2016 08 19;268:1-6. Epub 2016 Apr 19.

Departments of Neurology, Milton S. Hershey College of Medicine, The Pennsylvania State University, Hershey, PA 17033, United States; Departments of Pharmacology, Milton S. Hershey College of Medicine, The Pennsylvania State University, Hershey, PA 17033, United States; Department of Radiology, Milton S. Hershey College of Medicine, The Pennsylvania State University, Hershey, PA 17033, United States; Department of Neurosurgery, Milton S. Hershey College of Medicine, The Pennsylvania State University, Hershey, PA 17033, United States; Department of Kinesiology, Milton S. Hershey College of Medicine, The Pennsylvania State University, Hershey, PA 17033, United States. Electronic address:

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http://dx.doi.org/10.1016/j.jneumeth.2016.04.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4913043PMC
August 2016

Higher Plasma LDL-Cholesterol is Associated with Preserved Executive and Fine Motor Functions in Parkinson's Disease.

Aging Dis 2016 May 27;7(3):237-45. Epub 2016 May 27.

1Departments of Neurology, Pennsylvania State University-Milton S. Hershey Medical Center, Hershey PA 17033, USA.; 3Pharmacology, Pennsylvania State University-Milton S. Hershey Medical Center, Hershey PA 17033, USA.; 4Radiology, Pennsylvania State University-Milton S. Hershey Medical Center, Hershey PA 17033, USA.; 5Neurosurgery, Pennsylvania State University-Milton S. Hershey Medical Center, Hershey PA 17033, USA.; 6Kinesiology, Pennsylvania State University-Milton S. Hershey Medical Center, Hershey PA 17033, USA.

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http://dx.doi.org/10.14336/AD.2015.1030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4898920PMC
May 2016

Increased R2* in the Caudate Nucleus of Asymptomatic Welders.

Toxicol Sci 2016 Apr 14;150(2):369-77. Epub 2016 Jan 14.

*Department of Neurology, Pennsylvania State University College of Medicine, Hershey, Pennsylvania; Department of Environmental Sciences and Engineering, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, North Carolina; Department of Neurosurgery, Pennsylvania State University College of Medicine, Hershey, Pennsylvania; Department of Radiology, Pennsylvania State University College of Medicine, Hershey, Pennsylvania; and Department of Kinesiology, Pennsylvania State University, University Park, Pennsylvania

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http://dx.doi.org/10.1093/toxsci/kfw003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4857156PMC
April 2016

Quantitative susceptibility mapping of the midbrain in Parkinson's disease.

Mov Disord 2016 Mar 12;31(3):317-24. Epub 2015 Sep 12.

Department of Neurology, Penn State University-Milton S. Hershey Medical Center, Hershey, Pennsylvania, United States.

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http://dx.doi.org/10.1002/mds.26417DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5315570PMC
March 2016

Stage-dependent loss of cortical gyrification as Parkinson disease "unfolds".

Neurology 2016 Mar 17;86(12):1143-51. Epub 2016 Feb 17.

From the Departments of Neurology (N.W.S., L.Z., E.-Y.L., G.D., M.M.L., X.H.), Public Health Sciences (M.W.), Pharmacology (M.M.L., X.H.), Radiology (X.H.), Neurosurgery (X.H.), and Kinesiology (X.H.), Pennsylvania State University-Milton S. Hershey Medical Center; and Departments of Computer Science and Psychiatry (M.S.), University of North Carolina, Chapel Hill.

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http://www.neurology.org/content/early/2016/02/17/WNL.000000
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http://www.neurology.org/lookup/doi/10.1212/WNL.000000000000
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http://dx.doi.org/10.1212/WNL.0000000000002492DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4820131PMC
March 2016

Parkinson's disease biomarkers program brain imaging repository.

Neuroimage 2016 Jan 12;124(Pt B):1120-1124. Epub 2015 May 12.

Department of Applied Physiology and Kinesiology, University of Florida, Gainesville, FL 32611, USA; Department of Biomedical Engineering, University of Florida, Gainesville, FL 32611, USA; Department of Neurology, University of Florida, Gainesville, FL 32611, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neuroimage.2015.05.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4643422PMC
January 2016

Dopaminergic modulation of arm swing during gait among Parkinson's disease patients.

J Parkinsons Dis 2015 ;5(1):141-50

Department of Neurology, The Pennsylvania State University - Milton S. Hershey Medical Center, Hershey, PA, USA Department of Kinesiology, The Pennsylvania State University, University Park, PA, USA Department of Pharmacology, The Pennsylvania State University - Milton S. Hershey Medical Center, Hershey, PA, USA Department of Radiology, The Pennsylvania State University - Milton S. Hershey Medical Center, Hershey, PA, USA Department of Neurosurgery, The Pennsylvania State University - Milton S. Hershey Medical Center, Hershey, PA, USA.

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http://dx.doi.org/10.3233/JPD-140447DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4609542PMC
November 2015

T1 Relaxation Rate (R1) Indicates Nonlinear Mn Accumulation in Brain Tissue of Welders With Low-Level Exposure.

Toxicol Sci 2015 Aug 7;146(2):281-9. Epub 2015 May 7.

*Department of Neurology, Pennsylvania State University College of Medicine, Hershey, Pennsylvania, Department of Pharmacology, Pennsylvania State University College of Medicine, Hershey, Pennsylvania, Departments of Radiology, Pennsylvania State University College of Medicine, Hershey, Pennsylvania, Department of Kinesiology, Pennsylvania State University, University Park, Pennsylvania

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http://dx.doi.org/10.1093/toxsci/kfv088DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4607746PMC
August 2015

Side of motor onset is associated with hemisphere-specific memory decline and lateralized gray matter loss in Parkinson's disease.

Parkinsonism Relat Disord 2015 May 18;21(5):465-70. Epub 2015 Feb 18.

Department of Neurology, Pennsylvania State University-Milton S. Hershey Medical Center, Hershey, PA 17033, USA; Department of Pharmacology, Pennsylvania State University-Milton S. Hershey Medical Center, Hershey, PA 17033, USA; Department of Radiology, Pennsylvania State University-Milton S. Hershey Medical Center, Hershey, PA 17033, USA; Department of Neurosurgery, Pennsylvania State University-Milton S. Hershey Medical Center, Hershey, PA 17033, USA; Department of Kinesiology, Pennsylvania State University-Milton S. Hershey Medical Center, Hershey, PA 17033, USA. Electronic address:

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http://dx.doi.org/10.1016/j.parkreldis.2015.02.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4424064PMC
May 2015

CDKL2 promotes epithelial-mesenchymal transition and breast cancer progression.

Oncotarget 2014 Nov;5(21):10840-53

Texas Therapeutics Institute, Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center at Houston, Houston, Texas. Division of Oncology, Department of Internal Medicine, and Memorial Hermann Cancer Center, University of Texas Health Science Center at Houston, Houston, Texas. Cancer Biology Program, Graduate School of Biomedical Sciences, University of Texas Health Science Center at Houston, Houston, Texas.

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http://www.oncotarget.com/fulltext/2535
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4279414PMC
http://dx.doi.org/10.18632/oncotarget.2535DOI Listing
November 2014

Microstructural changes in the substantia nigra of asymptomatic agricultural workers.

Neurotoxicol Teratol 2014 Jan-Feb;41:60-4. Epub 2013 Dec 12.

Departments of Neurology, Pennsylvania State University-Milton S. Hershey Medical Center, Hershey, PA 17033, USA; Departments of Pharmacology, Pennsylvania State University-Milton S. Hershey Medical Center, Hershey, PA 17033, USA; Departments of Radiology, Pennsylvania State University-Milton S. Hershey Medical Center, Hershey, PA 17033, USA; Departments of Neurosurgery, Pennsylvania State University-Milton S. Hershey Medical Center, Hershey, PA 17033, USA; Departments of Kinesiology, Pennsylvania State University-Milton S. Hershey Medical Center, Hershey, PA 17033, USA; Departments of Bioengineering, Pennsylvania State University-Milton S. Hershey Medical Center, Hershey, PA 17033, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ntt.2013.12.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3943901PMC
October 2014

Transcriptional coactivator CBP upregulates hTERT expression and tumor growth and predicts poor prognosis in human lung cancers.

Oncotarget 2014 Oct;5(19):9349-61

Institute of Cancer Stem Cell & First Affiliated Hospital, Dalian Medical University, Dalian, China. Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China; Colaborative Innovation Center of Cancer Medicine, Guangzhou, China.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4253439PMC
http://dx.doi.org/10.18632/oncotarget.2430DOI Listing
October 2014

Olfactory-related cortical atrophy is associated with olfactory dysfunction in Parkinson's disease.

Mov Disord 2014 Aug 30;29(9):1205-8. Epub 2014 Jan 30.

Departments of Neurology, Pennsylvania State University-Milton S. Hershey Medical Center, Hershey, Pennsylvania, USA.

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http://dx.doi.org/10.1002/mds.25829DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4116478PMC
August 2014

Multi-atlas segmentation of subcortical brain structures via the AutoSeg software pipeline.

Front Neuroinform 2014 6;8. Epub 2014 Feb 6.

Department of Psychiatry, University of North Carolina Chapel Hill, NC, USA ; Department of Computer Science, University of North Carolina Chapel Hill, NC, USA.

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http://dx.doi.org/10.3389/fninf.2014.00007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3915103PMC
February 2014

Early cortical gray matter loss and cognitive correlates in non-demented Parkinson's patients.

Parkinsonism Relat Disord 2013 Dec 6;19(12):1088-93. Epub 2013 Aug 6.

Department of Neurology, Pennsylvania State University-Milton S. Hershey Medical Center, Hershey, PA 17033, USA.

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http://dx.doi.org/10.1016/j.parkreldis.2013.07.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3858507PMC
December 2013

Striatal shape in Parkinson's disease.

Neurobiol Aging 2013 Nov 29;34(11):2510-6. Epub 2013 Jun 29.

Department of Neurology, Pennsylvania State University-Milton S Hershey Medical Center, Hershey, PA 17033-0850, USA.

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http://dx.doi.org/10.1016/j.neurobiolaging.2013.05.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3742686PMC
November 2013

Retinoids activate the irritant receptor TRPV1 and produce sensory hypersensitivity.

J Clin Invest 2013 Sep 8;123(9):3941-51. Epub 2013 Aug 8.

Department of Integrative Biology and Pharmacology, University of Texas Health Science Center at Houston, Houston, Texas 77030, USA.

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http://dx.doi.org/10.1172/JCI66413DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3754244PMC
September 2013

miRNA and shRNA expression vectors based on mRNA and miRNA processing.

Methods Mol Biol 2013 ;936:195-207

Department of Integrative Biology and Pharmacology, University of Texas Health Science Center at Houston, Houston, TX, USA.

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http://link.springer.com/10.1007/978-1-62703-083-0_16
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http://dx.doi.org/10.1007/978-1-62703-083-0_16DOI Listing
June 2013

Phosphatidic acid is required for the constitutive ruffling and macropinocytosis of phagocytes.

Mol Biol Cell 2013 Jun 10;24(11):1700-12, S1-7. Epub 2013 Apr 10.

Division of Cell Biology, Hospital for Sick Children, Toronto, ON M5G 1X8, Canada.

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http://dx.doi.org/10.1091/mbc.E12-11-0789DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3667723PMC
June 2013

Higher iron in the red nucleus marks Parkinson's dyskinesia.

Neurobiol Aging 2013 May 21;34(5):1497-503. Epub 2012 Nov 21.

Department of Neurology, Pennsylvania State University-Milton S. Hershey Medical Center, Hershey, PA 17033-0850, USA.

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http://dx.doi.org/10.1016/j.neurobiolaging.2012.10.025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3570638PMC
May 2013

Phosphatidic acid regulation of PIPKI is critical for actin cytoskeletal reorganization.

J Lipid Res 2012 Dec 18;53(12):2598-609. Epub 2012 Sep 18.

Department of Pharmacology and Center for Developmental Genetics, Stony Brook University, Stony Brook, NY 11794, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3494241PMC
December 2012

Serum cholesterol and nigrostriatal R2* values in Parkinson's disease.

PLoS One 2012 17;7(4):e35397. Epub 2012 Apr 17.

Department of Neurology, Pennsylvania State University-Milton S. Hershey Medical Center, Hershey, Pennsylvania, United States of America.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3328461PMC
November 2012

Imaging nigral pathology and clinical progression in Parkinson's disease.

Mov Disord 2012 Nov 24;27(13):1636-43. Epub 2012 Sep 24.

Department of Neurology, Pennsylvania State University-Milton S. Hershey Medical Center, Hershey, Pennsylvania 17033-0850, USA.

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http://dx.doi.org/10.1002/mds.25182DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3510346PMC
November 2012

Dysregulated lipid metabolism in cancer.

World J Biol Chem 2012 Aug;3(8):167-74

Feng Zhang, Guangwei Du, Department of Integrative Biology and Pharmacology, The University of Texas Health Science Center at Houston, Houston, TX 77030, United States.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3430731PMC
August 2012

Both coordination and symmetry of arm swing are reduced in Parkinson's disease.

Gait Posture 2012 Mar 17;35(3):373-7. Epub 2011 Nov 17.

Department of Neurology, The Pennsylvania State University - Milton S. Hershey Medical Center, Hershey, PA 17033, USA.

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http://dx.doi.org/10.1016/j.gaitpost.2011.10.180DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3297736PMC
March 2012

Class III PI-3-kinase activates phospholipase D in an amino acid-sensing mTORC1 pathway.

J Cell Biol 2011 Oct 24;195(3):435-47. Epub 2011 Oct 24.

Department of Cell and Developmental Biology, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.

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http://dx.doi.org/10.1083/jcb.201107033DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3206351PMC
October 2011

Combined R2* and diffusion tensor imaging changes in the substantia nigra in Parkinson's disease.

Mov Disord 2011 Aug 26;26(9):1627-32. Epub 2011 May 26.

Department of Neurology, Pennsylvania State University-Milton S. Hershey Medical Center, Hershey, Pennsylvania 17033-0850, USA.

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http://dx.doi.org/10.1002/mds.23643DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3154471PMC
August 2011

Manganese accumulation in the olfactory bulbs and other brain regions of "asymptomatic" welders.

Toxicol Sci 2011 May 9;121(1):160-7. Epub 2011 Feb 9.

Department of Neurology, University of North Carolina at Chapel Hill, North Carolina 27599, USA.

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http://dx.doi.org/10.1093/toxsci/kfr033DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3080190PMC
May 2011

Therapeutic levels of the hydroxmethylglutaryl-coenzyme A reductase inhibitor lovastatin activate ras signaling via phospholipase D2.

Mol Cell Biol 2011 Mar 18;31(6):1110-20. Epub 2011 Jan 18.

Department of Integrative Biology and Pharmacology, The University of Texas Medical School-Houston, 6431 Fannin Street, Houston, TX 77030, USA.

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http://mcb.asm.org/cgi/doi/10.1128/MCB.00989-10
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3067913PMC
March 2011

Characterization of new serum biomarkers in breast cancer using lipid microarrays.

Tumour Biol 2010 Jun;31(3):181-7

Department of Integrative Biology and Pharmacology, The University of Texas Health Science Center at Houston, Houston, TX 77030, USA.

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June 2010

Dependence of phospholipase D1 multi-monoubiquitination on its enzymatic activity and palmitoylation.

J Biol Chem 2010 Apr 26;285(18):13580-8. Epub 2010 Feb 26.

Smooth Muscle Research Group, Libin Cardiovascular Institute of Alberta, Department of Biochemistry and Molecular Biology, University of Calgary, Calgary, Alberta T2N 4N1, Canada.

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http://dx.doi.org/10.1074/jbc.M109.046359DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2859519PMC
April 2010

Basis for the isoform-specific interaction of myosin phosphatase subunits protein phosphatase 1c beta and myosin phosphatase targeting subunit 1.

J Biol Chem 2010 Feb 30;285(9):6419-24. Epub 2009 Dec 30.

Department of Pharmacology, Stony Brook University, Stony Brook, New York 11794-5140, USA.

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http://dx.doi.org/10.1074/jbc.M109.074773DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2825437PMC
February 2010

Phosphatidic acid signaling regulation of Ras superfamily of small guanosine triphosphatases.

Biochim Biophys Acta 2009 Sep 21;1791(9):850-5. Epub 2009 Jun 21.

Department of Integrative Biology and Pharmacology University of Texas Health Science Center at Houston, Houston, TX 77030, USA.

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http://dx.doi.org/10.1016/j.bbalip.2009.05.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2739575PMC
September 2009

Phospholipase D1 regulates lymphocyte adhesion via upregulation of Rap1 at the plasma membrane.

Mol Cell Biol 2009 Jun 30;29(12):3297-306. Epub 2009 Mar 30.

The Cancer Institute, NYU School of Medicine, New York, New York 10016, USA.

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http://dx.doi.org/10.1128/MCB.00366-09DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2698734PMC
June 2009

pSM155 and pSM30 vectors for miRNA and shRNA expression.

Methods Mol Biol 2009 ;487:205-19

Department of Pharmacology and the Center for Developmental Genetics, Stony Brook University, Stony Brook, NY, USA.

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http://dx.doi.org/10.1007/978-1-60327-547-7_10DOI Listing
April 2009

5-Fluoro-2-indolyl des-chlorohalopemide (FIPI), a phospholipase D pharmacological inhibitor that alters cell spreading and inhibits chemotaxis.

Mol Pharmacol 2009 Mar 8;75(3):437-46. Epub 2008 Dec 8.

Departments of Biochemistry Pharmacology, Center for Developmental Genetics, Brook University, Stony Brook, New York, USA.

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http://dx.doi.org/10.1124/mol.108.053298DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2684902PMC
March 2009

A lipid-signaled myosin phosphatase surge disperses cortical contractile force early in cell spreading.

Mol Biol Cell 2009 Jan 22;20(1):200-8. Epub 2008 Oct 22.

Department of Pharmacology and Center for Developmental Genetics, Stony Brook University, Stony Brook, NY 11794.

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http://dx.doi.org/10.1091/mbc.e08-06-0555DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2613090PMC
January 2009

5' end cDNA amplification using classic RACE.

Nat Protoc 2006 ;1(6):2555-62

Graduate Program in Molecular & Cellular Pharmacology, Stony Brook University, Stony Brook, New York 11794, USA.

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http://dx.doi.org/10.1038/nprot.2006.480DOI Listing
November 2007

3' end cDNA amplification using classic RACE.

Nat Protoc 2006 ;1(6):2742-5

Graduate Program in Molecular & Cellular Pharmacology, Stony Brook University, Stony Brook, New York 11794, USA.

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http://dx.doi.org/10.1038/nprot.2006.481DOI Listing
November 2007

Amplification of 5' end cDNA with 'new RACE'.

Nat Protoc 2006 ;1(6):3056-61

Graduate Program in Molecular & Cellular Pharmacology, Stony Brook University, Stony Brook, New York 11794, USA.

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http://dx.doi.org/10.1038/nprot.2006.479DOI Listing
November 2007

Phospholipase D1 production of phosphatidic acid at the plasma membrane promotes exocytosis of large dense-core granules at a late stage.

J Biol Chem 2007 Jul 31;282(30):21746-57. Epub 2007 May 31.

Département Neurotransmission & Sécrétion Neuroendocrine, Institut des Neurosciences Cellulaires et Intégratives, CNRS and Université Louis Pasteur, 5 rue Blaise Pascal, Strasbourg, France.

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http://dx.doi.org/10.1074/jbc.M702968200DOI Listing
July 2007

Phospholipase D2-generated phosphatidic acid couples EGFR stimulation to Ras activation by Sos.

Nat Cell Biol 2007 Jun 7;9(6):706-12. Epub 2007 May 7.

Graduate Program in Genetics, Stony Brook University, Stony Brook NY 11794, USA.

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http://dx.doi.org/10.1038/ncb1594DOI Listing
June 2007

Design of expression vectors for RNA interference based on miRNAs and RNA splicing.

FEBS J 2006 Dec 31;273(23):5421-7. Epub 2006 Oct 31.

Department of Pharmacology and the Center for Developmental Genetics, Stony Brook University, NY 11794, USA.

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http://dx.doi.org/10.1111/j.1742-4658.2006.05534.xDOI Listing
December 2006

A role for Phospholipase D in Drosophila embryonic cellularization.

BMC Dev Biol 2006 Dec 7;6:60. Epub 2006 Dec 7.

Department of Pharmacology and Center for Developmental Genetics, Stony Brook University, Stony Brook, NY 11794-5140, USA.

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http://dx.doi.org/10.1186/1471-213X-6-60DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1698916PMC
December 2006

RhoA-mediated Phospholipase D1 signaling is not required for the formation of stress fibers and focal adhesions.

Cell Signal 2006 Apr 29;18(4):469-78. Epub 2005 Jun 29.

Department of Pharmacology and the Center for Developmental Genetics, State University of New York at Stony Brook, Stony Brook, NY 11794-5140, USA.

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http://dx.doi.org/10.1016/j.cellsig.2005.05.027DOI Listing
April 2006

Dynamics and function of phospholipase D and phosphatidic acid during phagocytosis.

Traffic 2006 Mar;7(3):365-77

Département Neurotransmission et Sécrétion Neuroendocrine, UMR 7168/LC2, CNRS/Université Louis Pasteur, Strasbourg, France.

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http://doi.wiley.com/10.1111/j.1600-0854.2006.00389.x
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March 2006

Presenilin-1 uses phospholipase D1 as a negative regulator of beta-amyloid formation.

Proc Natl Acad Sci U S A 2006 Feb 31;103(6):1941-6. Epub 2006 Jan 31.

Laboratory of Molecular and Cellular Neuroscience, and Fisher Center for Research on Alzheimer Disease, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA.

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http://dx.doi.org/10.1073/pnas.0510708103DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1413665PMC
February 2006

Peroxiredoxin II functions as a signal terminator for H2O2-activated phospholipase D1.

FEBS J 2005 Aug;272(15):3929-37

Department of Pharmacology and the Center for Developmental Genetics, University Medical Center at Stony Brook, NY 11794-5140, USA.

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http://doi.wiley.com/10.1111/j.1742-4658.2005.04809.x
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August 2005

Nectin-like molecule 1 is a protein 4.1N associated protein and recruits protein 4.1N from cytoplasm to the plasma membrane.

Biochim Biophys Acta 2005 May 25;1669(2):142-54. Epub 2005 Feb 25.

National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, National Human Genome Center, Beijing 100005, China.

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http://linkinghub.elsevier.com/retrieve/pii/S000527360500028
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http://dx.doi.org/10.1016/j.bbamem.2005.01.013DOI Listing
May 2005

Increased expression of two phospholipase D isoforms during experimentally induced hippocampal mossy fiber outgrowth.

Glia 2004 Apr;46(1):74-83

Department of Pharmacological Sciences, University Medical Center at Stony Brook, Stony Brook, New York 11794-8651, USA.

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http://dx.doi.org/10.1002/glia.10322DOI Listing
April 2004

Phospholipase D2 localizes to the plasma membrane and regulates angiotensin II receptor endocytosis.

Mol Biol Cell 2004 Mar 12;15(3):1024-30. Epub 2004 Jan 12.

Department of Pharmacology and the Center for Developmental Genetics, University Medical Center at Stony Brook, Stony Brook, New York 11794-5140, USA.

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http://www.molbiolcell.org/doi/10.1091/mbc.e03-09-0673
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http://dx.doi.org/10.1091/mbc.e03-09-0673DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC363061PMC
March 2004

Calphostin-C induction of vascular smooth muscle cell apoptosis proceeds through phospholipase D and microtubule inhibition.

J Biol Chem 2004 Feb 6;279(8):7112-8. Epub 2003 Dec 6.

Smooth Muscle Research Group, Department of Biochemistry & Molecular Biology, The University of Calgary, Calgary, Alberta T2N 4N1,Canada.

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http://dx.doi.org/10.1074/jbc.M310721200DOI Listing
February 2004

PLD1 regulates mTOR signaling and mediates Cdc42 activation of S6K1.

Curr Biol 2003 Dec;13(23):2037-44

Department of Cell and Structural Biology, University of Illinois at Urbana-Champaign, 601 S. Goodwin Avenue B107, Urbana, IL 61801, USA.

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http://dx.doi.org/10.1016/j.cub.2003.11.021DOI Listing
December 2003

Ca(2+)- and phospholipase D-dependent and -independent pathways activate mTOR signaling.

FEBS Lett 2003 Aug;550(1-3):51-6

Department of Medicine, Division of Hematology, Stony Brook University, Stony Brook, NY 11794-8151, USA.

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http://dx.doi.org/10.1016/s0014-5793(03)00816-0DOI Listing
August 2003

G-protein-coupled receptor regulation of phospholipase D.

Methods Enzymol 2002 ;345:265-74

Department of Pharmacology, Center for Developmental Genetics, State University of New York, Stony Brook, New York 11794, USA.

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http://dx.doi.org/10.1016/s0076-6879(02)45022-7DOI Listing
April 2002