Guanghou Shui

Guanghou Shui

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Constant light exposure causes dysregulation of sphingolipids and promotes steatohepatitis in high-fat fed rats.

J Gastroenterol Hepatol 2020 Feb 6. Epub 2020 Feb 6.

Department of Endocrinology, Xiangya Hospital, Central South University, Changsha, Hunan, China.

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http://dx.doi.org/10.1111/jgh.15005DOI Listing
February 2020

Nuclear Factor E2-Related Factor 2 Mediates Oxidative Stress-Induced Lipid Accumulation in Adipocytes by Increasing Adipogenesis and Decreasing Lipolysis.

Antioxid Redox Signal 2020 Jan 5;32(3):173-192. Epub 2019 Dec 5.

Key Laboratory of Zoonosis Research, Ministry of Education, College of Veterinary Medicine, Jilin University, Changchun, China.

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http://dx.doi.org/10.1089/ars.2019.7769DOI Listing
January 2020

Altered Expression Profile of Phosphatidylinositols in Erythrocytes of Alzheimer's Disease and Amnestic Mild Cognitive Impairment Patients.

J Alzheimers Dis 2020 ;73(2):811-818

Department of Neurology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.

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http://dx.doi.org/10.3233/JAD-190926DOI Listing
January 2020

Liver ChREBP Protects Against Fructose-induced Glycogenic Hepatotoxicity by Regulating L-type Pyruvate Kinase.

Diabetes 2020 Jan 23. Epub 2020 Jan 23.

Department of Pathophysiology, Obesity and Diabetes Research Center, Navy Medical University, Shanghai 200433, China

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http://dx.doi.org/10.2337/db19-0388DOI Listing
January 2020

Targeted lipidomics and transcriptomics profiling reveal the heterogeneity of visceral and subcutaneous white adipose tissue.

Life Sci 2020 Jan 29;245:117352. Epub 2020 Jan 29.

State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College and Beijing Key Laboratory of Drug Target and Screening Research, Beijing 100050, China. Electronic address:

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http://dx.doi.org/10.1016/j.lfs.2020.117352DOI Listing
January 2020

Phosphatidylserine synthase regulates cellular homeostasis through distinct metabolic mechanisms.

PLoS Genet 2019 12 23;15(12):e1008548. Epub 2019 Dec 23.

State Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, China.

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http://dx.doi.org/10.1371/journal.pgen.1008548DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6946173PMC
December 2019

High-Coverage Targeted Lipidomics Reveals Novel Serum Lipid Predictors and Lipid Pathway Dysregulation Antecedent to Type 2 Diabetes Onset in Normoglycemic Chinese Adults.

Diabetes Care 2019 Nov 27;42(11):2117-2126. Epub 2019 Aug 27.

Shanghai National Clinical Research Center for Endocrine and Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commision of the People's Republic of China, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao-Tong University School of Medicine, Shanghai, China

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http://dx.doi.org/10.2337/dc19-0100DOI Listing
November 2019

Myristoleic acid produced by enterococci reduces obesity through brown adipose tissue activation.

Gut 2019 Nov 19. Epub 2019 Nov 19.

Key Laboratory of Animal Ecology and Conservation Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China

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http://dx.doi.org/10.1136/gutjnl-2019-319114DOI Listing
November 2019

Adipose lipidomics and RNA-Seq analysis revealed the enhanced mitochondrial function in UCP1 knock-in pigs.

Biochim Biophys Acta Mol Cell Biol Lipids 2019 10 2;1864(10):1375-1383. Epub 2019 Jul 2.

State Key Laboratory of Animal Nutrition, Institute of Animal Science, Chinese Academy of Agricultural Sciences, Beijing 100193, China. Electronic address:

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http://dx.doi.org/10.1016/j.bbalip.2019.06.017DOI Listing
October 2019

Lipid Profiling Reveals Browning Heterogeneity of White Adipose Tissue by Β3-Adrenergic Stimulation.

Biomolecules 2019 Sep 3;9(9). Epub 2019 Sep 3.

State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College and Beijing Key Laboratory of Drug Target and Screening Research, Beijing 100050, China.

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http://dx.doi.org/10.3390/biom9090444DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6770315PMC
September 2019

Convergent genomic signatures of flight loss in birds suggest a switch of main fuel.

Nat Commun 2019 06 21;10(1):2756. Epub 2019 Jun 21.

Key Laboratory of Animal Ecology and Conservation Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, China.

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http://dx.doi.org/10.1038/s41467-019-10682-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6588704PMC
June 2019

Lipid storage regulator CdsA is essential for Drosophila metamorphosis.

J Genet Genomics 2019 Apr 3;46(4):231-234. Epub 2019 Apr 3.

State Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, 100101, China; University of Chinese Academy of Sciences, Beijing, 100049, China. Electronic address:

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http://dx.doi.org/10.1016/j.jgg.2019.02.008DOI Listing
April 2019

Microbiota Depletion Impairs Thermogenesis of Brown Adipose Tissue and Browning of White Adipose Tissue.

Cell Rep 2019 03;26(10):2720-2737.e5

State Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, PRC; Institute of Biological and Environmental Sciences, University of Aberdeen, Aberdeen AB24 2TZ, UK; CAS Center for Excellence in Animal Evolution and Genetics (CCEAEG), Beijing 100101, PRC. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2019.02.015DOI Listing
March 2019

Phosphatidylinositol-hydrolyzing phospholipase C4 modulates rice response to salt and drought.

Plant Cell Environ 2019 02 11;42(2):536-548. Epub 2018 Oct 11.

Department of Biology, University of Missouri, St. Louis, Missouri, USA.

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http://doi.wiley.com/10.1111/pce.13437
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http://dx.doi.org/10.1111/pce.13437DOI Listing
February 2019

Lipid-gene regulatory network reveals coregulations of triacylglycerol with phosphatidylinositol/lysophosphatidylinositol and with hexosyl-ceramide.

Biochim Biophys Acta Mol Cell Biol Lipids 2019 02 3;1864(2):168-180. Epub 2018 Dec 3.

State Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China; University of Chinese Academy of Sciences, Beijing 100049, China. Electronic address:

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http://dx.doi.org/10.1016/j.bbalip.2018.11.010DOI Listing
February 2019

Plasma lipidomic profiling in murine mutants of Hermansky-Pudlak syndrome reveals differential changes in pro- and anti-atherosclerotic lipids.

Biosci Rep 2019 02 19;39(2). Epub 2019 Feb 19.

Beijing Key Laboratory for Genetics of Birth Defects, Beijing Pediatric Research Institute; Genetics and Birth Defects Control Center, National Center for Children's Health; MOE Key Laboratory of Major Diseases in Children; Beijing Children's Hospital, Capital Medical University, Beijing 100045, China

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http://dx.doi.org/10.1042/BSR20182339DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6379572PMC
February 2019

γ-Aminobutyric Acid Attenuates High-Fat Diet-Induced Cerebral Oxidative Impairment via Enhanced Synthesis of Hippocampal Sulfatides.

J Agric Food Chem 2019 Jan 16;67(4):1081-1091. Epub 2019 Jan 16.

Key Laboratory of Food Nutrition and Safety, Ministry of Education , Tianjin University of Science and Technology , Tianjin 300457 , China.

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http://dx.doi.org/10.1021/acs.jafc.8b05246DOI Listing
January 2019

An integrated method for direct interrogation of sphingolipid homeostasis in the heart and brain tissues of mice through postnatal development up to reproductive senescence.

Anal Chim Acta 2018 Dec 3;1037:152-158. Epub 2018 Feb 3.

State Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, People's Republic of China; University of Chinese Academy of Sciences, Beijing, People's Republic of China. Electronic address:

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http://dx.doi.org/10.1016/j.aca.2018.01.015DOI Listing
December 2018

Correction: Guanylate-binding protein 2 regulates Drp1-mediated mitochondrial fission to suppress breast cancer cell invasion.

Cell Death Dis 2018 Nov 13;9(11):1127. Epub 2018 Nov 13.

Center for Core Facility and Advanced Technologies, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, 100101, Beijing, China.

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http://www.nature.com/articles/s41419-018-1133-5
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http://dx.doi.org/10.1038/s41419-018-1133-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6233216PMC
November 2018

cTAGE5/MEA6 plays a critical role in neuronal cellular components trafficking and brain development.

Proc Natl Acad Sci U S A 2018 10 17;115(40):E9449-E9458. Epub 2018 Sep 17.

State Key Laboratory of Molecular Developmental Biology, Chinese Academy of Sciences Center for Excellence in Brain Science and Intelligence Technology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, 100101 Beijing, China;

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http://www.pnas.org/lookup/doi/10.1073/pnas.1804083115
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http://dx.doi.org/10.1073/pnas.1804083115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6176567PMC
October 2018

Seipin regulates lipid homeostasis by ensuring calcium-dependent mitochondrial metabolism.

EMBO J 2018 09 26;37(17). Epub 2018 Jul 26.

State Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, China

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http://dx.doi.org/10.15252/embj.201797572DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6120665PMC
September 2018

Tip60-mediated lipin 1 acetylation and ER translocation determine triacylglycerol synthesis rate.

Nat Commun 2018 05 15;9(1):1916. Epub 2018 May 15.

State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Signaling Network, School of Life Sciences, Xiamen University, Fujian, 361102, China.

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http://dx.doi.org/10.1038/s41467-018-04363-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5953937PMC
May 2018

Gamma-aminobutyric Acid Enriched Rice Bran Diet Attenuates Insulin Resistance and Balances Energy Expenditure via Modification of Gut Microbiota and Short-Chain Fatty Acids.

J Agric Food Chem 2018 Jan 22;66(4):881-890. Epub 2018 Jan 22.

School of Medical and Applied Sciences, Central Queensland University , Rockhampton, Queensland 4700, Australia.

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http://pubs.acs.org/doi/10.1021/acs.jafc.7b04994
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http://dx.doi.org/10.1021/acs.jafc.7b04994DOI Listing
January 2018

GDSL lipases modulate immunity through lipid homeostasis in rice.

PLoS Pathog 2017 Nov 13;13(11):e1006724. Epub 2017 Nov 13.

National Key Laboratory of Plant Molecular Genetics, CAS Center for Excellence in Molecular Plant Sciences/Institute of Plant Physiology & Ecology, Chinese Academy of Sciences, Shanghai, China.

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http://dx.doi.org/10.1371/journal.ppat.1006724DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5703576PMC
November 2017

HDAC6 Suppresses Age-Dependent Ectopic Fat Accumulation by Maintaining the Proteostasis of PLIN2 in Drosophila.

Dev Cell 2017 10 28;43(1):99-111.e5. Epub 2017 Sep 28.

Sino-French Hoffmann Institute, School of Basic Sciences, Guangzhou Medical University, Dongfengxi Road 195, Guangzhou 510182, China; State Key Laboratory of Brain and Cognitive Science, Institute of Biophysics, the Chinese Academy of Sciences, Datun Road 15, Beijing 100101, China; University of Chinese Academy of Sciences, Beijing 100080, China; The Second Affiliated Hospital of Guangzhou Medical University, Changgangdong Road 250, Guangzhou 510260, China. Electronic address:

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http://dx.doi.org/10.1016/j.devcel.2017.09.001DOI Listing
October 2017

Guanylate-binding protein 2 regulates Drp1-mediated mitochondrial fission to suppress breast cancer cell invasion.

Cell Death Dis 2017 10 26;8(10):e3151. Epub 2017 Oct 26.

Center for Core Facility and Advanced Technologies, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China.

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http://www.nature.com/doifinder/10.1038/cddis.2017.559
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http://dx.doi.org/10.1038/cddis.2017.559DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5680924PMC
October 2017

Lipidomics, en route to accurate quantitation.

Biochim Biophys Acta Mol Cell Biol Lipids 2017 Aug 16;1862(8):752-761. Epub 2017 Feb 16.

State Key Laboratory of Molecular and Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, People's Republic of China; Lipidall Technologies Company Limited, Changzhou 213000, Jiangsu, People's Republic of China. Electronic address:

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http://dx.doi.org/10.1016/j.bbalip.2017.02.008DOI Listing
August 2017

Sequestration of polyunsaturated fatty acids in membrane phospholipids of Caenorhabditis elegans dauer larva attenuates eicosanoid biosynthesis for prolonged survival.

Redox Biol 2017 08 4;12:967-977. Epub 2017 May 4.

State Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, People's Republic of China. Electronic address:

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http://dx.doi.org/10.1016/j.redox.2017.05.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5429230PMC
August 2017

Requirement of cytosolic phospholipase A2 gamma in lipid droplet formation.

Biochim Biophys Acta Mol Cell Biol Lipids 2017 Jul 21;1862(7):692-705. Epub 2017 Mar 21.

State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan 430071, China; University of Chinese Academy of Sciences, Beijing, China. Electronic address:

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http://dx.doi.org/10.1016/j.bbalip.2017.03.007DOI Listing
July 2017

Drosophila TRF2 and TAF9 regulate lipid droplet size and phospholipid fatty acid composition.

PLoS Genet 2017 03 8;13(3):e1006664. Epub 2017 Mar 8.

State Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, China.

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http://dx.doi.org/10.1371/journal.pgen.1006664DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5362240PMC
March 2017

Metabolomics through the lens of precision cardiovascular medicine.

J Genet Genomics 2017 03 8;44(3):127-138. Epub 2017 Mar 8.

State Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China. Electronic address:

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http://dx.doi.org/10.1016/j.jgg.2017.02.004DOI Listing
March 2017

Acsl, the Drosophila ortholog of intellectual-disability-related ACSL4, inhibits synaptic growth by altered lipids.

J Cell Sci 2016 11 21;129(21):4034-4045. Epub 2016 Sep 21.

State Key Laboratory for Molecular and Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China

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http://dx.doi.org/10.1242/jcs.195032DOI Listing
November 2016

Metabolomics, a Powerful Tool for Agricultural Research.

Int J Mol Sci 2016 Nov 17;17(11). Epub 2016 Nov 17.

State Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China.

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http://dx.doi.org/10.3390/ijms17111871DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5133871PMC
November 2016

Biological relevance of fatty acyl heterogeneity to the neural membrane dynamics of rhesus macaques during normative aging.

Oncotarget 2016 08;7(35):55970-55989

State Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, China.

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http://dx.doi.org/10.18632/oncotarget.11190DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5302890PMC
August 2016

Mea6 controls VLDL transport through the coordinated regulation of COPII assembly.

Cell Res 2016 07 17;26(7):787-804. Epub 2016 Jun 17.

State Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China.

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http://dx.doi.org/10.1038/cr.2016.75DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5129886PMC
July 2016

Neonatal Respiratory Failure with Retarded Perinatal Lung Maturation in Mice Caused by Reticulocalbin 3 Disruption.

Am J Respir Cell Mol Biol 2016 Mar;54(3):410-23

1 State Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, China.

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http://dx.doi.org/10.1165/rcmb.2015-0036OCDOI Listing
March 2016

Discovering and validating between-subject variations in plasma lipids in healthy subjects.

Sci Rep 2016 Jan 8;6:19139. Epub 2016 Jan 8.

NUS Graduate School for Integrative Science and Engineering, National University of Singapore, Singapore.

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http://dx.doi.org/10.1038/srep19139DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4705481PMC
January 2016

Changes in Plasma Lipids during Exposure to Total Sleep Deprivation.

Sleep 2015 Nov 1;38(11):1683-91. Epub 2015 Nov 1.

Program in Neuroscience and Behavioral Disorders, Duke-NUS Graduate Medical School, Singapore.

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http://dx.doi.org/10.5665/sleep.5142DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4813350PMC
November 2015

Arabidopsis AtPLC2 Is a Primary Phosphoinositide-Specific Phospholipase C in Phosphoinositide Metabolism and the Endoplasmic Reticulum Stress Response.

PLoS Genet 2015 Sep 24;11(9):e1005511. Epub 2015 Sep 24.

Institute of Plant and Microbial Biology, Academia Sinica, Taipei, Taiwan; Molecular and Biological Agricultural Sciences Program, Taiwan International Graduate Program, Academia Sinica, Taipei, Taiwan; Graduate Institute of Biotechnology and Department of Life Sciences, National Chung-Hsing University, Taichung, Taiwan.

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http://dx.doi.org/10.1371/journal.pgen.1005511DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4581737PMC
September 2015

The Lipid-Modifying Enzyme SMPDL3B Negatively Regulates Innate Immunity.

Cell Rep 2015 Jun 18;11(12):1919-28. Epub 2015 Jun 18.

CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, 1090 Vienna, Austria; Center for Physiology and Pharmacology, Medical University of Vienna, 1090 Vienna, Austria. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2015.05.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4508342PMC
June 2015

Role of tetanus neurotoxin insensitive vesicle-associated membrane protein in membrane domains transport and homeostasis.

Cell Logist 2015 Jan-Mar;5(1):e1025182. Epub 2015 Apr 29.

INSERM; U950; Membrane Traffic in Health and Disease ; Paris, France ; Univ Paris Diderot ; Sorbonne Paris Cité; ERL U950 ; Paris, France ; CNRS; UMR 7592; Institut Jacques Monod ; Paris, France.

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http://dx.doi.org/10.1080/21592799.2015.1025182DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4501207PMC
April 2015

Evaluation of dietary effects on hepatic lipids in high fat and placebo diet fed rats by in vivo MRS and LC-MS techniques.

PLoS One 2014 17;9(3):e91436. Epub 2014 Mar 17.

Laboratory of Molecular Imaging, Singapore Bioimaging Consortium, A*STAR, Singapore, Singapore; Singapore Institute for Clinical Sciences, A*STAR, Singapore, Singapore.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0091436PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3956606PMC
January 2015

Lipidomics and genomics of Mycobacterium tuberculosis reveal lineage-specific trends in mycolic acid biosynthesis.

Microbiologyopen 2014 Dec 19;3(6):823-35. Epub 2014 Sep 19.

Mycobacterial Division Research, NIMR, MRC, NW71AA, London, United Kingdom; Department of Medical Parasitology and Infection Biology, Swiss TPH, 4002, Basel, Switzerland; University of Basel, 4002, Basel, Switzerland.

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http://doi.wiley.com/10.1002/mbo3.193
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http://dx.doi.org/10.1002/mbo3.193DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4263507PMC
December 2014

Brain lipidomes of subcortical ischemic vascular dementia and mixed dementia.

Neurobiol Aging 2014 Oct 1;35(10):2369-81. Epub 2014 Mar 1.

State Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, China. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S01974580140023
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http://dx.doi.org/10.1016/j.neurobiolaging.2014.02.025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4099521PMC
October 2014

Longitudinal changes in tear fluid lipidome brought about by eyelid-warming treatment in a cohort of meibomian gland dysfunction.

J Lipid Res 2014 Sep 3;55(9):1959-69. Epub 2014 Jul 3.

State Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, China.

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http://dx.doi.org/10.1194/jlr.P051185DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4617361PMC
September 2014

Distribution of secretory phospholipase A2 XIIA in the brain and its role in lipid metabolism and cognition.

Mol Neurobiol 2014 Aug 25;50(1):60-75. Epub 2014 Jan 25.

Department of Anatomy, National University of Singapore, Singapore, 119260, Singapore.

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http://dx.doi.org/10.1007/s12035-014-8635-7DOI Listing
August 2014

Adipose-specific knockout of SEIPIN/BSCL2 results in progressive lipodystrophy.

Diabetes 2014 Jul 12;63(7):2320-31. Epub 2014 Mar 12.

School of Biotechnology and Biomolecular Sciences, the University of New South Wales, Sydney, NSW, Australia

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http://dx.doi.org/10.2337/db13-0729DOI Listing
July 2014

Transcriptomic and lipidomic profiles of glycerolipids during Arabidopsis flower development.

New Phytol 2014 Jul 28;203(1):310-22. Epub 2014 Mar 28.

Institute of Plant and Microbial Biology, Academia Sinica, 128 sec.2 Academia Rd, Nankang, Taipei, 11529, Taiwan; PRESTO, Japan Science and Technology Agency, A-1-8 Honcho Kawaguchi, Saitama, Japan; Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, 28 Medical Drive, Singapore city, 117456, Singapore; Temasek Life Sciences Laboratory, 1 Research Link, National University of Singapore, Singapore city, 117604, Singapore.

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http://doi.wiley.com/10.1111/nph.12774
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http://dx.doi.org/10.1111/nph.12774DOI Listing
July 2014

The mitochondria-targeted antioxidant MitoQ extends lifespan and improves healthspan of a transgenic Caenorhabditis elegans model of Alzheimer disease.

Free Radic Biol Med 2014 Jun 15;71:390-401. Epub 2014 Mar 15.

Department of Biochemistry, National University of Singapore, Singapore 117597, Singapore.

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http://dx.doi.org/10.1016/j.freeradbiomed.2014.03.003DOI Listing
June 2014

Cidea control of lipid storage and secretion in mouse and human sebaceous glands.

Mol Cell Biol 2014 May 17;34(10):1827-38. Epub 2014 Mar 17.

MOE Key Laboratory of Bioinformatics and Tsinghua-Peking Center for Life Sciences, School of Life Sciences, Tsinghua University, Beijing, People's Republic of China.

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http://dx.doi.org/10.1128/MCB.01723-13DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4019032PMC
May 2014

Mfsd2a is a transporter for the essential omega-3 fatty acid docosahexaenoic acid.

Nature 2014 May 14;509(7501):503-6. Epub 2014 May 14.

Signature Research Program in Cardiovascular and Metabolic Disorders, Duke-NUS Graduate Medical School Singapore, 8 College Road, 169857 Singapore.

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http://dx.doi.org/10.1038/nature13241DOI Listing
May 2014

Lipid is moving to the forefront of bio-medical research.

J Genet Genomics 2014 May;41(5):229-30

State Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China. Electronic address:

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http://dx.doi.org/10.1016/j.jgg.2014.05.001DOI Listing
May 2014

Comprehensive analysis of lipid composition in crude palm oil using multiple lipidomic approaches.

J Genet Genomics 2014 May 26;41(5):293-304. Epub 2014 Apr 26.

State Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S16738527140007
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http://dx.doi.org/10.1016/j.jgg.2014.04.002DOI Listing
May 2014

CDP-diacylglycerol synthetase coordinates cell growth and fat storage through phosphatidylinositol metabolism and the insulin pathway.

PLoS Genet 2014 Mar 6;10(3):e1004172. Epub 2014 Mar 6.

State Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, China.

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http://dx.doi.org/10.1371/journal.pgen.1004172DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3945474PMC
March 2014

Extensive characterization of human tear fluid collected using different techniques unravels the presence of novel lipid amphiphiles.

J Lipid Res 2014 Feb 28;55(2):289-98. Epub 2013 Nov 28.

State Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, China.

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http://dx.doi.org/10.1194/jlr.M044826DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3886667PMC
February 2014

Lipidomic analysis of human tear fluid reveals structure-specific lipid alterations in dry eye syndrome.

J Lipid Res 2014 Feb 28;55(2):299-306. Epub 2013 Nov 28.

State Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, China.

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http://dx.doi.org/10.1194/jlr.P041780DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3886668PMC
February 2014

Critical role of SCD1 in autophagy regulation via lipogenesis and lipid rafts-coupled AKT-FOXO1 signaling pathway.

Autophagy 2014 Feb 26;10(2):226-42. Epub 2013 Nov 26.

Department of Physiology; Yong Loo Lin School of Medicine; National University of Singapore; Singapore; NUS Graduate School for Integrative Sciences and Engineering; National University of Singapore; Singapore.

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http://dx.doi.org/10.4161/auto.27003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5396079PMC
February 2014

TPS1 drug design for rice blast disease in magnaporthe oryzae.

Springerplus 2014 10;3:18. Epub 2014 Jan 10.

Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, 28 Medical Drive, Singapore, 117456 Singapore.

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http://dx.doi.org/10.1186/2193-1801-3-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3901853PMC
January 2014

Neonatal overnutrition in mice exacerbates high-fat diet-induced metabolic perturbations.

J Endocrinol 2013 Nov 4;219(2):131-43. Epub 2013 Oct 4.

Laboratory of Lipid and Glucose Metabolism, The First Affiliated Hospital of Chongqing Medical University, 1 Youyi Road, Yuzhong District, Chongqing 400016, People's Republic of China Laboratory of Metabolic Medicine, Singapore Bioimaging Consortium, Agency for Science Technology and Research (A*STAR), #02-02 Helios, 11 Biopolis Way, Singapore 138667, Singapore Division of Neuroscience, Oregon National Primate Research Center, Oregon Health and Science University, 505 NW 185th Avenue, Beaverton, Oregon 97006, USA Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 119275, Singapore.

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http://dx.doi.org/10.1530/JOE-13-0111DOI Listing
November 2013

Effects of a high-fat, high-cholesterol diet on brain lipid profiles in apolipoprotein E ε3 and ε4 knock-in mice.

Neurobiol Aging 2013 Sep 18;34(9):2217-24. Epub 2013 Apr 18.

School of Psychiatry and Clinical Neurosciences, The University of Western Australia, Nedlands, Australia.

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http://dx.doi.org/10.1016/j.neurobiolaging.2013.03.012DOI Listing
September 2013

Rapid and sensitive profiling of tear wax ester species using high performance liquid chromatography coupled with tandem mass spectrometry.

J Chromatogr A 2013 Sep 8;1308:166-71. Epub 2013 Aug 8.

State Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, China.

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http://dx.doi.org/10.1016/j.chroma.2013.08.016DOI Listing
September 2013

Lipidomics as a principal tool for advancing biomedical research.

J Genet Genomics 2013 Aug 12;40(8):375-90. Epub 2013 Jul 12.

State Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China.

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http://dx.doi.org/10.1016/j.jgg.2013.06.007DOI Listing
August 2013

A model of flux regulation in the cholesterol biosynthesis pathway: Immune mediated graduated flux reduction versus statin-like led stepped flux reduction.

Biochimie 2013 Mar 1;95(3):613-21. Epub 2012 Jun 1.

Division of Pathway Medicine, University of Edinburgh Medical School, Chancellor's Building, 49 Little France Crescent, Edinburgh, Scotland, United Kingdom.

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http://dx.doi.org/10.1016/j.biochi.2012.05.024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3585962PMC
March 2013

Ablation of dihydroceramide desaturase confers resistance to etoposide-induced apoptosis in vitro.

PLoS One 2012 11;7(9):e44042. Epub 2012 Sep 11.

Program in Cardiovascular and Metabolic Diseases, Duke-National University of Singapore Graduate Medical School, Singapore, Singapore.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3439484PMC
March 2013

PGC-1α improves glucose homeostasis in skeletal muscle in an activity-dependent manner.

Diabetes 2013 Jan 18;62(1):85-95. Epub 2012 Oct 18.

1Biozentrum, Division of Pharmacology/Neurobiology, University of Basel, Basel, Switzerland.

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http://dx.doi.org/10.2337/db12-0291DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3526021PMC
January 2013

Biochemical membrane lipidomics during Drosophila development.

Dev Cell 2013 Jan 20;24(1):98-111. Epub 2012 Dec 20.

Department of Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute, 4002 Basel, Switzerland.

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January 2013

Abc3-mediated efflux of an endogenous digoxin-like steroidal glycoside by Magnaporthe oryzae is necessary for host invasion during blast disease.

PLoS Pathog 2012 23;8(8):e1002888. Epub 2012 Aug 23.

Temasek Life Sciences Laboratory and Department of Biological Sciences, National University of Singapore, Singapore, Singapore.

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https://dx.plos.org/10.1371/journal.ppat.1002888
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3426555PMC
December 2012

Role of prefrontal cortical calcium independent phospholipase A₂ in antidepressant-like effect of maprotiline.

Int J Neuropsychopharmacol 2012 Sep 11;15(8):1087-98. Epub 2011 Aug 11.

Department of Pharmacology, National University of Singapore, Singapore.

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http://dx.doi.org/10.1017/S1461145711001234DOI Listing
September 2012

Meibum lipid composition in Asians with dry eye disease.

PLoS One 2011 17;6(10):e24339. Epub 2011 Oct 17.

Department of Biological Sciences, National University of Singapore, Singapore, Singapore.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3197196PMC
April 2012

Inhibitory effect of dietary lipids on chaperone-mediated autophagy.

Proc Natl Acad Sci U S A 2012 Mar 13;109(12):E705-14. Epub 2012 Feb 13.

Department of Developmental and Molecular Biology, Institute for Aging Studies, Marion Bessin Liver Research Center, Albert Einstein College of Medicine, Bronx, NY 10461, USA.

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http://dx.doi.org/10.1073/pnas.1113036109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3311383PMC
March 2012

Chondroitin fragments are odorants that trigger fear behavior in fish.

Curr Biol 2012 Mar 23;22(6):538-44. Epub 2012 Feb 23.

Neuroscience Research Partnership, Biomedical Sciences Institutes, 61 Biopolis Drive, Singapore 138673, Singapore.

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http://dx.doi.org/10.1016/j.cub.2012.01.061DOI Listing
March 2012

U18666A, an intra-cellular cholesterol transport inhibitor, inhibits dengue virus entry and replication.

Antiviral Res 2012 Jan 29;93(1):191-8. Epub 2011 Nov 29.

Dengue Unit, Novartis Institute for Tropical Diseases, 10 Biopolis Road, Chromos #05-01, Singapore 138670, Singapore.

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http://dx.doi.org/10.1016/j.antiviral.2011.11.014DOI Listing
January 2012

Cidea is an essential transcriptional coactivator regulating mammary gland secretion of milk lipids.

Nat Med 2012 Jan 15;18(2):235-43. Epub 2012 Jan 15.

Tsinghua-Peking Center for Life Sciences, School of Life Sciences, Tsinghua University, Beijing, China.

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http://www.nature.com/articles/nm.2614
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January 2012

Molecular characterization of seipin and its mutants: implications for seipin in triacylglycerol synthesis.

J Lipid Res 2011 Dec 26;52(12):2136-47. Epub 2011 Sep 26.

School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, NSW, Australia.

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http://dx.doi.org/10.1194/jlr.M017566DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3220282PMC
December 2011

Fsp27 promotes lipid droplet growth by lipid exchange and transfer at lipid droplet contact sites.

J Cell Biol 2011 Dec 5;195(6):953-63. Epub 2011 Dec 5.

Peking-Tsinghua Center for Life Sciences, Tsinghua University, Beijing 100084, China.

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http://dx.doi.org/10.1083/jcb.201104142DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3241734PMC
December 2011

The size and phospholipid composition of lipid droplets can influence their proteome.

Biochem Biophys Res Commun 2011 Nov 25;415(3):455-62. Epub 2011 Oct 25.

School of Biotechnology and Biomolecular Sciences, The University of New South Wales, Sydney NSW 2052, Australia.

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http://dx.doi.org/10.1016/j.bbrc.2011.10.091DOI Listing
November 2011

Derivatization-independent cholesterol analysis in crude lipid extracts by liquid chromatography/mass spectrometry: applications to a rabbit model for atherosclerosis.

J Chromatogr A 2011 Jul 13;1218(28):4357-65. Epub 2011 May 13.

Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.

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http://dx.doi.org/10.1016/j.chroma.2011.05.011DOI Listing
July 2011