Grigory L Dianov

Grigory L Dianov

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Grigory L Dianov

Grigory L Dianov

Publications by authors named "Grigory L Dianov"

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69Publications

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Interplay between base excision repair protein XRCC1 and ALDH2 predicts overall survival in lung and liver cancer patients.

Cell Oncol (Dordr) 2018 Oct 7;41(5):527-539. Epub 2018 Aug 7.

CRUK & MRC Oxford Institute for Radiation Oncology, Department of Oncology, University of Oxford, Old Road Campus Research Building, Oxford, OX3 7DQ, UK.

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October 2018

Persistent DNA strand breaks induce a CAF-like phenotype in normal fibroblasts.

Oncotarget 2018 Mar 7;9(17):13666-13681. Epub 2018 Feb 7.

CRUK & MRC Oxford Institute for Radiation Oncology, University of Oxford, Department of Oncology, Old Road Campus Research Building, OX37DQ Oxford, UK.

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March 2018

Sp1 phosphorylation by ATM downregulates BER and promotes cell elimination in response to persistent DNA damage.

Nucleic Acids Res 2018 Feb;46(4):1834-1846

Department of Oncology, CRUK & MRC Oxford Institute for Radiation Oncology, University of Oxford, Old Road Campus Research Building, Oxford OX3 7DQ, UK.

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February 2018

Modulation of proteostasis counteracts oxidative stress and affects DNA base excision repair capacity in ATM-deficient cells.

Nucleic Acids Res 2017 Sep;45(17):10042-10055

CRUK & MRC Oxford Institute for Radiation Oncology, University of Oxford, Department of Oncology, Old Road Campus Research Building, Oxford OX37DQ, UK.

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September 2017

DNA Base Excision Repair: The Achilles' Heel of Tumour Cells and their Microenvironment?

Curr Pharm Des 2017 ;23(32):4758-4772

CRUK and MRC Oxford Institute for Radiation Oncology, University of Oxford, Department of Oncology, Old Road Campus Research Building, OX37DQ Oxford. United Kingdom.

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January 2017

DNA Damage and Repair in Schizophrenia and Autism: Implications for Cancer Comorbidity and Beyond.

Int J Mol Sci 2016 Jun 1;17(6). Epub 2016 Jun 1.

Cancer Research UK and Medical Research Council Oxford Institute for Radiation Oncology, Department of Oncology, University of Oxford, Oxford OX3 7DQ, UK.

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June 2016

p53 coordinates base excision repair to prevent genomic instability.

Nucleic Acids Res 2016 Apr 14;44(7):3165-75. Epub 2016 Jan 14.

CRUK & MRC Oxford Institute for Radiation Oncology, University of Oxford, Department of Oncology, Old Road Campus Research Building, OX37DQ Oxford, UK Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences, Lavrenteva 10, 630090 Novosibirsk, Russia

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April 2016

Cells deficient in base-excision repair reveal cancer hallmarks originating from adjustments to genetic instability.

Nucleic Acids Res 2015 Apr 23;43(7):3667-79. Epub 2015 Mar 23.

Cancer Research UK and Medical Research Council Oxford Institute for Radiation Oncology, Department of Oncology, University of Oxford, Roosevelt Drive, Oxford OX3 7DQ, United Kingdom Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences, Lavrenteva 10, 630090 Novosibirsk, Russia

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April 2015

ATM prevents DSB formation by coordinating SSB repair and cell cycle progression.

Proc Natl Acad Sci U S A 2015 Mar 16;112(13):3997-4002. Epub 2015 Mar 16.

Cancer Research UK and Medical Research Council Oxford Institute for Radiation Oncology, Department of Oncology, University of Oxford, Oxford OX3 7DQ, United Kingdom; and

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March 2015

AKT regulates NPM dependent ARF localization and p53mut stability in tumors.

Oncotarget 2014 Aug;5(15):6142-67

Cancer Research UK/MRC Oxford Institute, Department of Oncology, University of Oxford, Old Road Campus, Roosevelt Drive, UK.

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August 2014

ARF induction in response to DNA strand breaks is regulated by PARP1.

Nucleic Acids Res 2014 Feb 29;42(4):2320-9. Epub 2013 Nov 29.

Department of Oncology, Gray Institute for Radiation Oncology and Biology, University of Oxford, Roosevelt Drive, Oxford OX3 7DQ, UK.

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February 2014

Co-ordination of base excision repair and genome stability.

DNA Repair (Amst) 2013 May 7;12(5):326-33. Epub 2013 Mar 7.

Department of Molecular and Clinical Cancer Medicine, Cancer Research Centre, University of Liverpool, 200 London Road, Liverpool, L3 9TA, UK.

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May 2013

Mammalian base excision repair: the forgotten archangel.

Nucleic Acids Res 2013 Apr 13;41(6):3483-90. Epub 2013 Feb 13.

Department of Oncology, Gray Institute for Radiation Oncology and Biology, University of Oxford, Old Road Campus Research Building, Roosevelt Drive, Oxford OX3 7DQ, UK.

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April 2013

USP7S-dependent inactivation of Mule regulates DNA damage signalling and repair.

Nucleic Acids Res 2013 Feb 28;41(3):1750-6. Epub 2012 Dec 28.

Gray Institute for Radiation Oncology and Biology, Department of Oncology, University of Oxford, Oxford, OX3 7DQ, UK.

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February 2013

In vitro base excision repair using mammalian cell extracts.

Methods Mol Biol 2012 ;920:245-62

Gray Institute for Radiation, Oncology and Biology, University of Oxford, Oxford, UK.

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January 2013

Phosphorylation of PNKP by ATM prevents its proteasomal degradation and enhances resistance to oxidative stress.

Nucleic Acids Res 2012 Dec 5;40(22):11404-15. Epub 2012 Oct 5.

Gray Institute for Radiation Oncology and Biology, Department of Oncology, University of Oxford, Roosevelt Drive, Oxford OX3 7DQ, UK.

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December 2012

ATM-dependent downregulation of USP7/HAUSP by PPM1G activates p53 response to DNA damage.

Mol Cell 2012 Mar 21;45(6):801-13. Epub 2012 Feb 21.

Department of Oncology, Gray Institute for Radiation Oncology and Biology, University of Oxford, Oxford OX3 7DQ, UK.

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March 2012

Ubiquitin ligase UBR3 regulates cellular levels of the essential DNA repair protein APE1 and is required for genome stability.

Nucleic Acids Res 2012 Jan 20;40(2):701-11. Epub 2011 Sep 20.

Gray Institute for Radiation Oncology and Biology, University of Oxford, Old Road Campus Research Building, Roosevelt Drive, Oxford OX3 7DQ, UK.

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January 2012

Regulation of oxidative DNA damage repair by DNA polymerase λ and MutYH by cross-talk of phosphorylation and ubiquitination.

Proc Natl Acad Sci U S A 2012 Jan 27;109(2):437-42. Epub 2011 Dec 27.

Institute for Veterinary Biochemistry and Molecular Biology, University of Zürich-Irchel, Winterthurerstrasse 190, CH-8057 Zürich, Switzerland.

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January 2012

Base excision repair targets for cancer therapy.

Authors:
Grigory L Dianov

Am J Cancer Res 2011 12;1(7):845-51. Epub 2011 Aug 12.

Gray Institute for Radiation Oncology and Biology, Department of Oncology, University of Oxford, Old Road Campus Research Building Roosevelt Drive, Oxford 0X3 7DQ, UK.

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November 2011

The emerging role of Mule and ARF in the regulation of base excision repair.

FEBS Lett 2011 Sep 30;585(18):2831-5. Epub 2011 Jun 30.

Gray Institute for Radiation Oncology and Biology, Department of Oncology, University of Oxford, Old Road Campus Research Building, Roosevelt Drive, Oxford OX3 7DQ, UK.

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September 2011

CK2 phosphorylation of XRCC1 facilitates dissociation from DNA and single-strand break formation during base excision repair.

DNA Repair (Amst) 2011 Sep 15;10(9):961-9. Epub 2011 Aug 15.

Department of Genetics, Microbiology and Toxicology, Stockholm University, S-106 91 Stockholm, Sweden.

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September 2011

USP7/HAUSP stimulates repair of oxidative DNA lesions.

Nucleic Acids Res 2011 Apr 7;39(7):2604-9. Epub 2010 Dec 7.

Gray Institute for Radiation Oncology & Biology, University of Oxford, Old Road Campus Research Building, Old Road Campus, Roosevelt Drive, Oxford OX3 7DQ, UK.

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April 2011

USP47 is a deubiquitylating enzyme that regulates base excision repair by controlling steady-state levels of DNA polymerase β.

Mol Cell 2011 Mar;41(5):609-15

Gray Institute for Radiation Oncology and Biology, University of Oxford, Roosevelt Drive, Oxford OX3 7DQ, UK.

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March 2011

Nijmegen breakage syndrome protein (NBN) causes resistance to methylating anticancer drugs such as temozolomide.

Mol Pharmacol 2010 Nov 20;78(5):943-51. Epub 2010 Aug 20.

Institute of Toxicology, Medical Center of the University Mainz, Obere Zahlbacher Str 67, D-55131 Mainz, Germany.

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November 2010

XRCC1 phosphorylation by CK2 is required for its stability and efficient DNA repair.

DNA Repair (Amst) 2010 Jul 14;9(7):835-41. Epub 2010 May 14.

Gray Institute for Radiation Oncology & Biology, University of Oxford, United Kingdom.

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July 2010

The role of mammalian NEIL1 protein in the repair of 8-oxo-7,8-dihydroadenine in DNA.

FEBS Lett 2010 Apr 7;584(8):1553-7. Epub 2010 Mar 7.

SB RAS Institute of Chemical Biology and Fundamental Medicine, Novosibirsk, Russia.

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April 2010

Mechanism of action of an imidopiperidine inhibitor of human polynucleotide kinase/phosphatase.

J Biol Chem 2010 Jan 23;285(4):2351-60. Epub 2009 Nov 23.

Department of Experimental Oncology, Cross Cancer Institute, Edmonton, Alberta T6G 1Z2, Canada.

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January 2010

Aprataxin, poly-ADP ribose polymerase 1 (PARP-1) and apurinic endonuclease 1 (APE1) function together to protect the genome against oxidative damage.

Hum Mol Genet 2009 Nov 30;18(21):4102-17. Epub 2009 Jul 30.

Queensland Institute of Medical Research, Radiation Biology and Oncology, Brisbane, Queensland 4029, Australia.

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November 2009

Ubiquitin ligase ARF-BP1/Mule modulates base excision repair.

EMBO J 2009 Oct 27;28(20):3207-15. Epub 2009 Aug 27.

Gray Institute for Radiation Oncology and Biology, University of Oxford, Oxford, UK.

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October 2009

Poly ADP-ribose polymerase-1: an international molecule of mystery.

DNA Repair (Amst) 2008 Jul 12;7(7):1077-86. Epub 2008 May 12.

Medical Research Council Radiation Oncology & Biology Unit, University of Oxford, Oxford OX3 7DQ, UK.

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July 2008

Poly(ADP-ribose) polymerase-1 modulates DNA repair capacity and prevents formation of DNA double strand breaks.

DNA Repair (Amst) 2008 Jun 12;7(6):932-40. Epub 2008 May 12.

Medical Research Council Radiation Oncology & Biology Unit, University of Oxford, Old Road Campus Research Building, Roosevelt Drive, Oxford OX3 7DQ, UK.

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June 2008

Targeting base excision repair to improve cancer therapies.

Mol Aspects Med 2007 Jun-Aug;28(3-4):345-74. Epub 2007 Jul 5.

Radiation Oncology & Biology, University of Oxford, Churchill Hospital, Oxford OX3 7LJ, UK.

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February 2008

CHIP-mediated degradation and DNA damage-dependent stabilization regulate base excision repair proteins.

Mol Cell 2008 Feb;29(4):477-87

Medical Research Council Radiation Oncology and Biology Unit, University of Oxford, Oxfordshire OX1 3QU, UK.

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February 2008

Overexpression of DNA polymerase beta results in an increased rate of frameshift mutations during base excision repair.

Mutagenesis 2007 May 31;22(3):183-8. Epub 2007 Jan 31.

Radiation and Genome Stability Unit, Medical Research Council, Harwell, Oxfordshire OX11 0RD, UK.

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May 2007

Co-ordination of DNA single strand break repair.

DNA Repair (Amst) 2007 Apr 22;6(4):454-60. Epub 2006 Nov 22.

MRC Radiation and Genome Stability Unit, Medical Research Council, Harwell, Oxfordshire OX11 0RD, UK.

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April 2007

DNA polymerase delta-dependent repair of DNA single strand breaks containing 3'-end proximal lesions.

Nucleic Acids Res 2007 30;35(4):1054-63. Epub 2007 Jan 30.

MRC Radiation and Genome Stability Unit, Harwell, Oxfordshire, UK.

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April 2007

NEIL1 is the major DNA glycosylase that processes 5-hydroxyuracil in the proximity of a DNA single-strand break.

Biochemistry 2007 Apr 10;46(13):4158-63. Epub 2007 Mar 10.

MRC Radiation and Genome Stability Unit, Harwell, Oxfordshire OX11 0RD, UK.

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April 2007

Impact of copper on the induction and repair of oxidative DNA damage, poly(ADP-ribosyl)ation and PARP-1 activity.

Mol Nutr Food Res 2007 Feb;51(2):201-10

Institut für Lebensmitteltechnologie und Lebensmittelchemie, Technische Universität Berlin, Berlin, Germany.

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February 2007

Impact of arsenite and its methylated metabolites on PARP-1 activity, PARP-1 gene expression and poly(ADP-ribosyl)ation in cultured human cells.

DNA Repair (Amst) 2007 Jan 29;6(1):61-70. Epub 2006 Sep 29.

Institut für Lebensmitteltechnologie und Lebensmittelchemie, Technische Universität Berlin, 13355 Berlin, Germany.

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January 2007

Base excision repair fidelity in normal and cancer cells.

Mutagenesis 2006 May 13;21(3):173-8. Epub 2006 Apr 13.

Radiation and Genome Stability Unit, Medical Research Council Harwell, Oxfordshire, UK.

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May 2006

Repair of tandem base lesions in DNA by human cell extracts generates persisting single-strand breaks.

J Mol Biol 2005 Sep;351(5):1020-9

MRC Radiation and Genome Stability Unit, Harwell, Oxfordshire OX11 0RD, UK.

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September 2005

Isolation of a small molecule inhibitor of DNA base excision repair.

Nucleic Acids Res 2005 19;33(15):4711-24. Epub 2005 Aug 19.

Cancer Research UK Laboratories, Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital Oxford, OX3 9DS, UK.

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September 2005

NEIL1 excises 3' end proximal oxidative DNA lesions resistant to cleavage by NTH1 and OGG1.

Nucleic Acids Res 2005 29;33(15):4849-56. Epub 2005 Aug 29.

MRC Radiation and Genome Stability Unit Harwell, Oxfordshire, OX11 0RD, UK.

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September 2005

DNA polymerase beta promotes recruitment of DNA ligase III alpha-XRCC1 to sites of base excision repair.

Biochemistry 2005 Aug;44(31):10613-9

Radiation and Genome Stability Unit, Medical Research Council, Harwell, Oxfordshire OX11 0RD, UK.

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August 2005

APE1-dependent repair of DNA single-strand breaks containing 3'-end 8-oxoguanine.

Nucleic Acids Res 2005 14;33(7):2204-9. Epub 2005 Apr 14.

MRC Radiation and Genome Stability Unit, Harwell Oxfordshire OX11 0RD, UK.

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May 2005

DNA repair fidelity of base excision repair pathways in human cell extracts.

DNA Repair (Amst) 2005 Feb;4(2):263-70

Radiation and Genome Stability Unit, Medical Research Council, Harwell, Oxfordshire, OX11 0RD, UK.

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February 2005

Exchangeability of mammalian DNA ligases between base excision repair pathways.

Biochemistry 2004 Oct;43(40):12924-30

Radiation and Genome Stability Unit, Medical Research Council, Harwell, Oxfordshire OX11 0RD, United Kingdom.

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October 2004

APE1 is the major 3'-phosphoglycolate activity in human cell extracts.

Nucleic Acids Res 2004 6;32(12):3531-6. Epub 2004 Jul 6.

MRC Radiation and Genome Stability Unit, Harwell, Oxfordshire OX11 0RD, UK.

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July 2004

XRCC1-DNA polymerase beta interaction is required for efficient base excision repair.

Nucleic Acids Res 2004 11;32(8):2550-5. Epub 2004 May 11.

Radiation and Genome Stability Unit, Medical Research Council, Harwell, Oxfordshire OX11 0RD, UK.

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June 2004

WRN helicase and FEN-1 form a complex upon replication arrest and together process branchmigrating DNA structures associated with the replication fork.

Mol Biol Cell 2004 Feb 2;15(2):734-50. Epub 2003 Dec 2.

Laboratory of Molecular Gerontology, National Institute on Aging, National Institutes of Health, Baltimore, Maryland 21224, USA.

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February 2004

Orchestration of base excision repair by controlling the rates of enzymatic activities.

DNA Repair (Amst) 2004 Jan;3(1):23-31

MRC Radiation and Genome Stability Unit, Medical Research Council, Harwell, OX11 0RD, Oxfordshire, UK.

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January 2004

Poly(ADP-ribose) polymerase in base excision repair: always engaged, but not essential for DNA damage processing.

Acta Biochim Pol 2003 ;50(1):169-79

MRC Radiation and Genome Stability Unit, Harwell, Oxfordshire, OX11 0RD, UK.

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December 2003

Monitoring base excision repair by in vitro assays.

Authors:
Grigory L Dianov

Toxicology 2003 Nov;193(1-2):35-41

MRC Radiation and Genome Stability Unit, Medical Research Council, Harwell, OX11 0RD Oxfordshire, UK.

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November 2003

Repair of abasic sites in DNA.

Mutat Res 2003 Oct;531(1-2):157-63

Radiation & Genome Stability Unit, Medical Research Council, Harwell, Oxfordshire OX11 0RD, UK.

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October 2003

Mode of inhibition of short-patch base excision repair by thymine glycol within clustered DNA lesions.

J Biol Chem 2003 Mar 8;278(11):9378-81. Epub 2003 Jan 8.

Medical Research Council Radiation and Genome Stability Unit, Harwell, Oxfordshire OX11 0RD, United Kingdom.

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March 2003

Repair of dihydrouracil supported by base excision repair in mNTH1 knock-out cell extracts.

J Biol Chem 2002 Dec 24;277(52):50487-90. Epub 2002 Oct 24.

Medical Research Council Radiation and Genome Stability Unit, Harwell, Oxfordshire, OX11 0RD, United Kingdom.

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December 2002

Biochemical characterization of the WRN-FEN-1 functional interaction.

Biochemistry 2002 Oct;41(40):12204-16

Laboratory of Molecular Gerontology, National Institute on Aging, National Institutes of Health, 5600 Nathan Shock Drive, Baltimore, MD 21224, USA.

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October 2002

Repair of clustered DNA lesions. Sequence-specific inhibition of long-patch base excision repair be 8-oxoguanine.

J Biol Chem 2002 Jun 28;277(24):21300-5. Epub 2002 Mar 28.

Medical Research Council Radiation and Genome Stability Unit, Harwell, Oxfordshire OX11 0RD, United Kingdom.

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June 2002

Global genome repair of 8-oxoG in hamster cells requires a functional CSB gene product.

Oncogene 2002 May;21(22):3571-8

Department of Molecular and Structural Biology, University of Aarhus, DK-8000 Aarhus C, Denmark.

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May 2002

Reconstitution of human DNA polymerase delta using recombinant baculoviruses: the p12 subunit potentiates DNA polymerizing activity of the four-subunit enzyme.

J Biol Chem 2002 Feb 15;277(6):3894-901. Epub 2001 Nov 15.

Department of Biological Sciences, Vanderbilt University, Nashville, Tennessee 37232, USA.

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February 2002