Gregory V Nikiforovich

Gregory V Nikiforovich

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Gregory V Nikiforovich

Gregory V Nikiforovich

Publications by authors named "Gregory V Nikiforovich"

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32Publications

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Structural mechanisms of constitutive activation in the C5a receptors with mutations in the extracellular loops: molecular modeling study.

Proteins 2012 Jan 30;80(1):71-80. Epub 2011 Sep 30.

MolLife Design LLC, St. Louis, Missouri 63141, USA.

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January 2012

Exploring new near-infrared fluorescent disulfide-based cyclic RGD peptide analogs for potential integrin-targeted optical imaging.

Bioorg Med Chem Lett 2011 Apr 23;21(7):2116-20. Epub 2011 Feb 23.

Department of Radiology, Washington University School of Medicine, 4525 Scott Avenue, St Louis, MO 63110, USA.

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April 2011

Computational modeling of constitutively active mutants of GPCRs C5a receptor.

Methods Enzymol 2010 ;485:369-91

MolLife Design LLC, St. Louis, Missouri, USA.

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March 2011

Simplified modeling approach suggests structural mechanisms for constitutive activation of the C5a receptor.

Proteins 2011 Mar 30;79(3):787-802. Epub 2010 Nov 30.

MolLife Design, LLC, St. Louis, Missouri 63141, USA.

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March 2011

Constitutive activity of neural melanocortin receptors.

Methods Enzymol 2010 ;484:267-79

Department of Anatomy, Physiology and Pharmacology, College of Veterinary Medicine, Auburn University, Auburn, Alabama, USA.

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February 2011

Structural models for the complex of chemotaxis inhibitory protein of Staphylococcus aureus with the C5a receptor.

Biochem Biophys Res Commun 2009 Dec 30;390(3):481-4. Epub 2009 Sep 30.

MolLife Design LLC, 751 Aramis Drive, St. Louis, MO 63141, USA.

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December 2009

Structure of the complement factor 5a receptor-ligand complex studied by disulfide trapping and molecular modeling.

J Biol Chem 2008 Mar 14;283(12):7763-75. Epub 2008 Jan 14.

Department of Medicine, Washington University School of Medicine, St. Louis, Missouri 63110, USA.

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March 2008

Conformational movement of F251 contributes to the molecular mechanism of constitutive activation in the C5a receptor.

Chem Biol Drug Des 2008 Mar 29;71(3):197-204. Epub 2008 Jan 29.

Division of Endocrinology, Metabolism and Lipid Research, Department of Internal Medicine, Washington University School of Medicine, Box 8127, St Louis, MO 63110, USA.

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March 2008

Modeling molecular mechanisms of binding of the anaphylatoxin C5a to the C5a receptor.

Biochemistry 2008 Mar 15;47(10):3117-30. Epub 2008 Feb 15.

Center for Computational Biology, Department of Biochemistry and Molecular Biophysics, Washington University Medical School, St. Louis, Missouri 63110, USA.

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March 2008

Defining the interface between the C-terminal fragment of alpha-transducin and photoactivated rhodopsin.

Biophys J 2007 Jun 9;92(12):4325-34. Epub 2007 Mar 9.

Department of Biochemistry and Molecular Biophysics, Washington University School of Medicine, St. Louis, Missouri 63110, USA.

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June 2007

Conformational templates for rational drug design: flexibility of cyclo(D-Pro1-Ala2-Ala3-Ala4-Ala5) in DMSO solution.

J Med Chem 2007 Jun 11;50(12):2921-5. Epub 2007 May 11.

Department of Biochemistry and Molecular Biophysics, Washington University School of Medicine, St. Louis, Missouri 63110, USA.

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June 2007

Modeling of the complex between transducin and photoactivated rhodopsin, a prototypical G-protein-coupled receptor.

Biochemistry 2007 Apr 31;46(16):4734-44. Epub 2007 Mar 31.

Center for Computational Biology and Department of Biochemistry and Molecular Biophysics, Washington University Medical School, St. Louis, Missouri 63110, USA.

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April 2007

Molecular modeling suggests conformational scaffolds specifically targeting five subtypes of somatostatin receptors.

Chem Biol Drug Des 2007 Mar;69(3):163-9

Department of Biochemistry and Molecular Biology, Washington University Medical School, St. Louis, MO 63110, USA.

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March 2007

A comprehensive structure-function map of the intracellular surface of the human C5a receptor. II. Elucidation of G protein specificity determinants.

J Biol Chem 2007 Feb 6;282(5):3122-33. Epub 2006 Nov 6.

Department of Medicine and Molecular Biology, Washington University School of Medicine, St. Louis, Missouri 63110, USA.

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February 2007

A comprehensive structure-function map of the intracellular surface of the human C5a receptor. I. Identification of critical residues.

J Biol Chem 2007 Feb 29;282(5):3105-21. Epub 2006 Nov 29.

Department of Medicine and Molecular Biology, Washington School of Medicine, Missouri 63110, USA.

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February 2007

Targeting Beta-3 integrin using a linear hexapeptide labeled with a near-infrared fluorescent molecular probe.

Mol Pharm 2006 Sep-Oct;3(5):539-49

Department of Radiology, Washington University School of Medicine, St Louis, Missouri 63110, USA.

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January 2007

A minimalistic 3D pharmacophore model for cyclopentapeptide CXCR4 antagonists.

Biopolymers 2006 ;84(5):459-71

Center for Computational Biology, Department of Biochemistry and Molecular Biophysics, Washington University School of Medicine, 660 S. Euclid Avenue, St. Louis, MO 63110, USA.

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December 2006

Comparison of the retinitis pigmentosa mutations in rhodopsin with a functional map of the C5a receptor.

Vision Res 2006 Dec 8;46(27):4519-31. Epub 2006 Sep 8.

Department of Medicine, Washington University in St. Louis, Campus Box 8127, 660 S. Euclid Ave., St. Louis, MO 63110, USA.

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December 2006

Interactions between conserved residues in transmembrane helices 2 and 7 during angiotensin AT1 receptor activation.

Chem Biol Drug Des 2006 Nov;68(5):239-49

Department of Biochemistry and Molecular Biophysics, Washington University Medical School, St Louis, MO 63110, USA.

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November 2006

3D modeling of the activated states of constitutively active mutants of rhodopsin.

Biochem Biophys Res Commun 2006 Jun 25;345(1):430-7. Epub 2006 Apr 25.

Department of Biochemistry and Molecular Biophysics, Washington University School of Medicine, St. Louis, MO 63110, USA.

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June 2006

Insight into the binding mode for cyclopentapeptide antagonists of the CXCR4 receptor.

Chem Biol Drug Des 2006 May;67(5):346-54

Department of Biochemistry and Molecular Biophysics, Center for Computational Biology, Washington University School of Medicine, 700 South Euclid Avenue, St Louis, MO 63110, USA.

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May 2006

Genetic analysis of the first and third extracellular loops of the C5a receptor reveals an essential WXFG motif in the first loop.

J Biol Chem 2006 Apr 27;281(17):12010-9. Epub 2006 Feb 27.

Department of Medicine, Washington University School of Medicine, St. Louis, Missouri 63110, USA.

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April 2006

Modeling flexible loops in the dark-adapted and activated states of rhodopsin, a prototypical G-protein-coupled receptor.

Biophys J 2005 Dec 30;89(6):3780-9. Epub 2005 Sep 30.

Department of Biochemistry and Molecular Biophysics, Washington University School of Medicine, St. Louis, Missouri 63110, USA.

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December 2005

Possible locally driven folding pathways of TC5b, a 20-residue protein.

Proteins 2003 Aug;52(2):292-302

Department of Biochemistry and Molecular Biophysics, Washington University, St. Louis, Missouri 63110, USA.

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August 2003

Three-dimensional model for meta-II rhodopsin, an activated G-protein-coupled receptor.

Biochemistry 2003 Aug;42(30):9110-20

Department of Biochemistry and Molecular Biophysics, Washington University School of Medicine, St. Louis, Missouri 63110, USA.

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August 2003

Synthesis and characterization of a macrocyclic near-infrared optical scaffold.

J Am Chem Soc 2003 Jul;125(26):7766-7

Department of Radiology, Washington University, St. Louis, Missouri 63110, USA.

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July 2003

The search for local native-like nucleation centers in the unfolded state of beta -sheet proteins.

Proc Natl Acad Sci U S A 2002 Aug 24;99(16):10388-93. Epub 2002 Jul 24.

Department of Biochemistry and Molecular Biophysics, Washington University School of Medicine, 660 South Euclid Avenue, St. Louis, MO 63110, USA.

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August 2002