Gregory V Kryukov

Gregory V Kryukov

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Gregory V Kryukov

Gregory V Kryukov

Publications by authors named "Gregory V Kryukov"

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Analysis of cancer genomes reveals basic features of human aging and its role in cancer development.

Nat Commun 2016 08 12;7:12157. Epub 2016 Aug 12.

Division of Genetics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1038/ncomms12157DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4990632PMC
August 2016

Genetic Effect of Chemotherapy Exposure in Children of Testicular Cancer Survivors.

Clin Cancer Res 2016 05 2;22(9):2183-9. Epub 2015 Dec 2.

Broad Institute of MIT and Harvard, Cambridge, Massachusetts. Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.

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http://dx.doi.org/10.1158/1078-0432.CCR-15-2317DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4854770PMC
May 2016

ARID1B is a specific vulnerability in ARID1A-mutant cancers.

Nat Med 2014 Mar 23;20(3):251-4. Epub 2014 Feb 23.

1] Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA. [2] Division of Hematology/Oncology, Boston Children's Hospital, Boston, Massachusetts, USA. [3] Department of Pediatrics, Harvard Medical School, Boston, Massachusetts, USA. [4] Broad Institute of Harvard and MIT, Boston, Massachusetts, USA. [5] Center for Cancer Genome Discovery, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1038/nm.3480DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3954704PMC
March 2014

The genetic landscape of clinical resistance to RAF inhibition in metastatic melanoma.

Cancer Discov 2014 Jan 21;4(1):94-109. Epub 2013 Nov 21.

1Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School; 2Department of Pathology, Massachusetts General Hospital Cancer Center, Boston; 3Broad Institute of MIT and Harvard; 4Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology (MIT), Cambridge, Massachusetts; 5Department of Dermatology, University Hospital, West German Cancer Center, University Duisburg-Essen, Essen; 6German Cancer Consortium (DKTK); 7Department of Dermatology, Heidelberg University Hospital, Heidelberg; 8Department of Dermatology and Allergy, Hannover Medical School, Hannover; 9Department of Dermatology, University of Wuerzburg, Wuerzburg; 10Department of Dermatology, Venerology and Allergology, University of Schleswig-Holstein Hospital, Kiel; 11Department of Dermatology and Allergology, Ludwig-Maximilian University, Munich; 12Department of Dermatology, Venerology and Allergy, Charité Universitätsmedizin Berlin, Humboldt University, Berlin; 13Department of Dermatology, University of Mainz, Mainz; 14University Medical Center, University of Tübingen, Tübingen, Germany; 15Department of Genome Sciences, University of Washington, Seattle, Washington; 16Department of Dermatology, University Hospital Zurich, Zurich, Switzerland; and 17First Department of Medicine, Medical School, University of Athens, Athens, Greece.

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http://dx.doi.org/10.1158/2159-8290.CD-13-0617DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3947264PMC
January 2014

Highly recurrent TERT promoter mutations in human melanoma.

Science 2013 Feb 24;339(6122):957-9. Epub 2013 Jan 24.

Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.

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http://dx.doi.org/10.1126/science.1229259DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4423787PMC
February 2013

Impact of deleterious passenger mutations on cancer progression.

Proc Natl Acad Sci U S A 2013 Feb 6;110(8):2910-5. Epub 2013 Feb 6.

Graduate Program in Biophysics, Harvard University, Boston, MA 02115, USA.

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http://dx.doi.org/10.1073/pnas.1213968110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3581883PMC
February 2013

iSyTE: integrated Systems Tool for Eye gene discovery.

Invest Ophthalmol Vis Sci 2012 Mar 21;53(3):1617-27. Epub 2012 Mar 21.

Division of Genetics, Department of Medicine, Brigham and Women’s Hospital, Harvard edical School, Boston, Massachusetts, USA.

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http://iovs.arvojournals.org/article.aspx?doi=10.1167/iovs.1
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http://dx.doi.org/10.1167/iovs.11-8839DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3339920PMC
March 2012

Pooled association tests for rare variants in exon-resequencing studies.

Am J Hum Genet 2010 Jun 13;86(6):832-8. Epub 2010 May 13.

Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA.

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http://dx.doi.org/10.1016/j.ajhg.2010.04.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3032073PMC
June 2010

Human mutation rate associated with DNA replication timing.

Nat Genet 2009 Apr 15;41(4):393-5. Epub 2009 Mar 15.

Department of Genome Sciences and Medicine, University of Washington, Seattle, WA, USA.

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http://dx.doi.org/10.1038/ng.363DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2914101PMC
April 2009

Power of deep, all-exon resequencing for discovery of human trait genes.

Proc Natl Acad Sci U S A 2009 Mar 6;106(10):3871-6. Epub 2009 Feb 6.

Division of Genetics, Brigham and Women's Hospital, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA.

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http://dx.doi.org/10.1073/pnas.0812824106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2656172PMC
March 2009

New developments in selenium biochemistry: selenocysteine biosynthesis in eukaryotes and archaea.

Biol Trace Elem Res 2007 Dec;119(3):234-41

Molecular Biology of Selenium Section, Laboratory of Cancer Prevention, Center for Cancer Research, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1007/s12011-007-8003-9DOI Listing
December 2007

Selenoprotein H is a nucleolar thioredoxin-like protein with a unique expression pattern.

J Biol Chem 2007 Apr 1;282(16):11960-8. Epub 2007 Mar 1.

Department of Biochemistry, University of Nebraska, Lincoln, Nebraska 68588, USA.

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http://dx.doi.org/10.1074/jbc.M701605200DOI Listing
April 2007

Most rare missense alleles are deleterious in humans: implications for complex disease and association studies.

Am J Hum Genet 2007 Apr 8;80(4):727-39. Epub 2007 Mar 8.

Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Boston, MA 02125, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S000292970761104
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http://dx.doi.org/10.1086/513473DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1852724PMC
April 2007

Is there a twenty third amino acid in the genetic code?

Trends Genet 2006 Jul 19;22(7):357-60. Epub 2006 May 19.

Department of Biochemistry, University of Nebraska, Lincoln, NE 68588, USA.

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http://dx.doi.org/10.1016/j.tig.2006.05.002DOI Listing
July 2006

The Plasmodium selenoproteome.

Nucleic Acids Res 2006 20;34(2):496-505. Epub 2006 Jan 20.

Department of Biochemistry, University of Nebraska, Lincoln, NE 68588, USA.

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http://dx.doi.org/10.1093/nar/gkj450DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1342035PMC
February 2006

Evolutionary constraints in conserved nongenic sequences of mammals.

Genome Res 2005 Oct;15(10):1373-8

Institute of Evolutionary Biology, School of Biological Sciences, University of Edinburgh, Edinburgh EH9 3JT, United Kingdom.

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http://www.genome.org/cgi/doi/10.1101/gr.3942005
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http://dx.doi.org/10.1101/gr.3942005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1240079PMC
October 2005

Small fitness effect of mutations in highly conserved non-coding regions.

Hum Mol Genet 2005 Aug 30;14(15):2221-9. Epub 2005 Jun 30.

Division of Genetics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.

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http://www.slas.ac.cn/upload/20080417-4.pdf
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http://www.hmg.oxfordjournals.org/cgi/doi/10.1093/hmg/ddi226
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http://dx.doi.org/10.1093/hmg/ddi226DOI Listing
August 2005

Identification of trace element-containing proteins in genomic databases.

Annu Rev Nutr 2004 ;24:579-96

Department of Biochemistry, University of Nebraska, Lincoln, Nebraska 68588-0664, USA.

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http://dx.doi.org/10.1146/annurev.nutr.24.012003.132241DOI Listing
November 2004

Identification and characterization of phosphoseryl-tRNA[Ser]Sec kinase.

Proc Natl Acad Sci U S A 2004 Aug 18;101(35):12848-53. Epub 2004 Aug 18.

Molecular Biology of Selenium Section, Laboratory of Cancer Prevention, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1073/pnas.0402636101DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC516484PMC
August 2004

The prokaryotic selenoproteome.

EMBO Rep 2004 May 23;5(5):538-43. Epub 2004 Apr 23.

Department of Biochemistry, University of Nebraska, Lincoln, Nebraska 68588-0664, USA.

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http://dx.doi.org/10.1038/sj.embor.7400126DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1299047PMC
May 2004

Reconsidering the evolution of eukaryotic selenoproteins: a novel nonmammalian family with scattered phylogenetic distribution.

EMBO Rep 2004 Jan;5(1):71-7

Grup de Recerca en Informàtica Biomèdica, Institut Municipal d'Investigació Mèdica, Universitat Pompeu Fabra, Dr. Aiguader 80, 08003 Barcelona, Catalonia, Spain.

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http://embor.embopress.org/cgi/doi/10.1038/sj.embor.7400036
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http://dx.doi.org/10.1038/sj.embor.7400036DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1298953PMC
January 2004

Spatial and temporal expression patterns of selenoprotein genes during embryogenesis in zebrafish.

Gene Expr Patterns 2003 Aug;3(4):525-32

Institut de Génétique et Biologie Moléculaire et Cellulaire, CNRS/INSERM/Université Louis Pasteur, 1 rue Laurent Fries, BP 10142, CU de Strasbourg, 67404 Illkirch, France.

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http://dx.doi.org/10.1016/s1567-133x(03)00054-1DOI Listing
August 2003

Characterization of mammalian selenoproteomes.

Science 2003 May;300(5624):1439-43

Department of Biochemistry, University of Nebraska, Lincoln, NE 68588-0664, USA.

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http://www.sciencemag.org/cgi/doi/10.1126/science.1083516
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http://dx.doi.org/10.1126/science.1083516DOI Listing
May 2003

Mammalian selenoprotein gene signature: identification and functional analysis of selenoprotein genes using bioinformatics methods.

Methods Enzymol 2002 ;347:84-100

Department of Biochemistry, University of Nebraska, Lincoln, Nebraska 68588, USA.

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http://dx.doi.org/10.1016/s0076-6879(02)47010-3DOI Listing
August 2002

Selenoprotein R is a zinc-containing stereo-specific methionine sulfoxide reductase.

Proc Natl Acad Sci U S A 2002 Apr;99(7):4245-50

Department of Biochemistry, University of Nebraska, Lincoln, NE 68588-0664, USA.

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http://dx.doi.org/10.1073/pnas.072603099DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC123633PMC
April 2002