Gregory S Korbutt

Gregory S Korbutt

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Gregory S Korbutt

Gregory S Korbutt

Publications by authors named "Gregory S Korbutt"

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Co-localized immune protection using dexamethasone-eluting micelles in a murine islet allograft model.

Am J Transplant 2020 Mar 24;20(3):714-725. Epub 2019 Nov 24.

Alberta Diabetes Institute, University of Alberta, Edmonton, Alberta, Canada.

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http://dx.doi.org/10.1111/ajt.15662DOI Listing
March 2020

Fibrin supports subcutaneous neonatal porcine islet transplantation without the need for pre-vascularization.

Xenotransplantation 2019 Dec 9:e12575. Epub 2019 Dec 9.

Alberta Diabetes Institute, University of Alberta, Edmonton, Alberta, Canada.

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http://dx.doi.org/10.1111/xen.12575DOI Listing
December 2019

A20 as an immune tolerance factor can determine islet transplant outcomes.

JCI Insight 2019 Nov 1;4(21). Epub 2019 Nov 1.

Immunology Department, Garvan Institute of Medical Research, Darlinghurst, New South Wales, Australia.

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http://dx.doi.org/10.1172/jci.insight.131028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6948770PMC
November 2019

Cotransplantation of Mesenchymal Stem Cells With Neonatal Porcine Islets Improve Graft Function in Diabetic Mice.

Diabetes 2017 05 28;66(5):1312-1321. Epub 2017 Feb 28.

Alberta Diabetes Institute, University of Alberta, Edmonton, Alberta, Canada

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http://dx.doi.org/10.2337/db16-1068DOI Listing
May 2017

The effect of additive compounds on glycerol-induced damage to human chondrocytes.

Cryobiology 2017 04 10;75:68-74. Epub 2017 Feb 10.

Department of Surgery, University of Alberta Hospital, 2D2.28 WMC, 8440-112St, Edmonton, Alberta T6G 2B7, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.cryobiol.2017.02.002DOI Listing
April 2017

Porcine Islet Xenografts: a Clinical Source of ß-Cell Grafts.

Curr Diab Rep 2017 03;17(3):14

Department of Surgery, University of Alberta, 5.002 Li Ka Shing Bldg, 8602 112 Street, Edmonton, AB, T6G 2E1, Canada.

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http://dx.doi.org/10.1007/s11892-017-0846-7DOI Listing
March 2017

Porcine Islet-Specific Tolerance Induced by the Combination of Anti-LFA-1 and Anti-CD154 mAbs Is Dependent on PD-1.

Cell Transplant 2016 23;25(2):327-42. Epub 2015 Jun 23.

Alberta Diabetes Institute, Surgical-Medical Research Institute, Department of Surgery, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada.

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http://dx.doi.org/10.3727/096368915X688506DOI Listing
December 2016

Optimization and Scale-up Isolation and Culture of Neonatal Porcine Islets: Potential for Clinical Application.

Cell Transplant 2016 15;25(3):539-47. Epub 2015 Sep 15.

Department of Surgery, University of Alberta, Edmonton, Canada.

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http://dx.doi.org/10.3727/096368915X689451DOI Listing
December 2016

Collagen-chitosan-laminin hydrogels for the delivery of insulin-producing tissue.

J Tissue Eng Regen Med 2016 10 30;10(10):E397-E408. Epub 2013 Oct 30.

Division of Cardiac Surgery, University of Ottawa Heart Institute, Ottawa, Canada.

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http://dx.doi.org/10.1002/term.1829DOI Listing
October 2016

Justifying clinical trials for porcine islet xenotransplantation.

Xenotransplantation 2015 Sep-Oct;22(5):336-44

Department of Surgery, University of Alberta, Edmonton, AB, Canada.

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http://dx.doi.org/10.1111/xen.12196DOI Listing
June 2016

Tunable collagen hydrogels are modified by the therapeutic agents they are designed to deliver.

J Biomater Sci Polym Ed 2012 8;23(11):1467-83. Epub 2012 May 8.

a Division of Cardiac Surgery, University of Ottawa Heart Institute , 40 Ruskin Street , Ottawa , ON , Canada , K1Y4W7.

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http://dx.doi.org/10.1163/092050611X584397DOI Listing
May 2016

Development and Characterization of a Collagen-Based Matrix for Vascularization and Cell Delivery.

Biores Open Access 2015 1;4(1):188-97. Epub 2015 Mar 1.

Department of Surgery, University of Alberta , Edmonton, Canada . ; Alberta Diabetes Institute, University of Alberta , Edmonton, Canada .

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http://www.liebertpub.com/doi/10.1089/biores.2015.0007
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http://dx.doi.org/10.1089/biores.2015.0007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4497631PMC
August 2015

Bioengineering a highly vascularized matrix for the ectopic transplantation of islets.

Islets 2013 Sep-Dec;5(5):216-25. Epub 2013 Nov 21.

Department of Surgery; University of Alberta; Edmonton, AB Canada; Alberta Diabetes Institute; University of Alberta; Edmonton, AB Canada.

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http://dx.doi.org/10.4161/isl.27175DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4010574PMC
January 2015

Evaluation of a collagen-chitosan hydrogel for potential use as a pro-angiogenic site for islet transplantation.

PLoS One 2013 18;8(10):e77538. Epub 2013 Oct 18.

University of Ottawa Heart Institute, Ottawa, Canada ; Department of Cellular & Molecular Medicine, University of Ottawa, Ottawa, Canada.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0077538PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3799615PMC
August 2014

Glyoxalase-1 overexpression in bone marrow cells reverses defective neovascularization in STZ-induced diabetic mice.

Cardiovasc Res 2014 Feb 20;101(2):306-16. Epub 2013 Nov 20.

Division of Cardiac Surgery, University of Ottawa Heart Institute, 40 Ruskin Street, Ottawa, ON, Canada K1Y 4W7.

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http://dx.doi.org/10.1093/cvr/cvt259DOI Listing
February 2014

Identification and differentiation of PDX1 β-cell progenitors within the human pancreatic epithelium.

World J Diabetes 2014 Feb;5(1):59-68

Karen L Seeberger, Sarah J Anderson, Cara E Ellis, Telford Y Yeung, Gregory S Korbutt, Alberta Diabetes Institute, University of Alberta, Edmonton, Alberta, T6G 2E1, Canada.

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http://dx.doi.org/10.4239/wjd.v5.i1.59DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3932428PMC
February 2014

Nondividing, postpubertal rat sertoli cells resumed proliferation after transplantation.

Biol Reprod 2014 Jan 23;90(1):13. Epub 2014 Jan 23.

Department of Cell Biology and Biochemistry, Texas Tech University Health Sciences Center, Lubbock, Texas.

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http://dx.doi.org/10.1095/biolreprod.113.110197DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4076399PMC
January 2014

Possible link between ectopic pancreas and holoprosencephaly.

Islets 2012 May-Jun;4(3):207-9. Epub 2012 May 1.

Clinical Islet Transplant Program, University of Alberta, Edmonton, AB, Canada.

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http://dx.doi.org/10.4161/isl.20478DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3442818PMC
March 2013

Human mesenchymal stem cells protect human islets from pro-inflammatory cytokines.

PLoS One 2012 30;7(5):e38189. Epub 2012 May 30.

Department of Surgery, 5-002 Li Ka Shing Centre for Health Research Innovation, University of Alberta, Edmonton, Alberta, Canada.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0038189PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3364233PMC
October 2012

Vascularization of collagen-chitosan scaffolds with circulating progenitor cells as potential site for islet transplantation.

J Control Release 2011 Nov;152 Suppl 1:e196-8

Division of Cardiac Surgery, University of Ottawa Heart Institute, 40 Ruskin Street, Ottawa K1Y 4W7, Canada.

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http://dx.doi.org/10.1016/j.jconrel.2011.09.005DOI Listing
November 2011

Isolation and culture of human multipotent stromal cells from the pancreas.

Methods Mol Biol 2011 ;698:123-40

Alberta Diabetes Institute, University of Alberta, Edmonton, AB, Canada.

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http://dx.doi.org/10.1007/978-1-60761-999-4_10DOI Listing
July 2011

Alginate modification improves long-term survival and function of transplanted encapsulated islets.

Tissue Eng Part A 2009 Jun;15(6):1301-9

Alberta Diabetes Institute, University of Alberta, Edmonton, AB, Canada.

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http://dx.doi.org/10.1089/ten.tea.2008.0118DOI Listing
June 2009

Epithelial cells within the human pancreas do not coexpress mesenchymal antigens: epithelial-mesenchymal transition is an artifact of cell culture.

Lab Invest 2009 Feb 15;89(2):110-21. Epub 2008 Dec 15.

Alberta Diabetes Institute, University of Alberta, Edmonton, AB, Canada.

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http://www.nature.com/articles/labinvest2008122
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http://dx.doi.org/10.1038/labinvest.2008.122DOI Listing
February 2009

Prolonged survival of microencapsulated neonatal porcine islet xenografts in immune-competent mice without antirejection therapy.

Cell Transplant 2008 ;17(10-11):1243-56

Surgical-Medical Research Institute, Department of Surgery, University of Alberta, Edmonton, Alberta, Canada.

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http://dx.doi.org/10.3727/096368908787236602DOI Listing
February 2009

Sertoli cell line lacks the immunoprotective properties associated with primary Sertoli cells.

Cell Transplant 2008 ;17(5):525-34

Cell Biology and Biochemistry, Texas Tech University Health Sciences Center, Lubbock, TX 79430, USA.

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http://dx.doi.org/10.3727/096368908785096033DOI Listing
January 2009

The use of an approved biodegradable polymer scaffold as a solid support system for improvement of islet engraftment.

Artif Organs 2008 Dec;32(12):990-3

Surgical-Medical Research Institute, University of Alberta, Edmonton, Canada.

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http://dx.doi.org/10.1111/j.1525-1594.2008.00688.xDOI Listing
December 2008

What type of islets should be used?

Xenotransplantation 2008 Mar-Apr;15(2):81-2

Surgical-Medical Research Institute, University of Alberta, Edmonton, AB, Canada.

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http://dx.doi.org/10.1111/j.1399-3089.2008.00455.xDOI Listing
October 2008

Comparison of successful and unsuccessful islet/Sertoli cell cotransplant grafts in streptozotocin-induced diabetic mice.

Cell Transplant 2008 ;16(10):1029-38

Cell Biology and Biochemistry, Texas Tech University Health Sciences Center, Lubbock, TX 79430, USA.

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July 2008

Treatment of obesity and diabetes in mice by transplant of gut cells engineered to produce leptin.

Mol Ther 2008 Jun 15;16(6):1138-45. Epub 2008 Apr 15.

Laboratory of Molecular and Cellular Medicine, Department of Cellular and Physiological Sciences, Life Sciences Institute, University of British Columbia, Vancouver, British Columbia, Canada.

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http://dx.doi.org/10.1038/mt.2008.62DOI Listing
June 2008

Long-term graft function after allogeneic islet transplantation.

Cell Transplant 2007 ;16(4):441-6

Clinical Islet Transplant Program, University of Alberta and Capital Health Authority, Edmonton, Alberta, Canada.

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December 2007

NMR assessment of Me(2)SO in decellularized cryopreserved aortic valve conduits.

J Surg Res 2007 Jul 18;141(1):60-7. Epub 2007 May 18.

Department of Surgery, University of Alberta, Edmonton, Alberta, Canada.

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http://dx.doi.org/10.1016/j.jss.2007.03.082DOI Listing
July 2007

Delayed functional maturation of neonatal porcine islets in recipients under strict glycemic control.

Xenotransplantation 2007 Jul;14(4):333-8

Surgical-Medical Research Institute, University of Alberta, Edmonton, AB, Canada.

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http://dx.doi.org/10.1111/j.1399-3089.2007.00414.xDOI Listing
July 2007

Long-Term Graft Function after Allogeneic Islet Transplantation.

Cell Transplant 2007 Apr;16(4):441-446

Clinical Islet Transplant Program, University of Alberta and Capital Health Authority, Edmonton, Alberta, Canada.

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http://dx.doi.org/10.3727/000000007783464849DOI Listing
April 2007

Immune mechanisms associated with the rejection of encapsulated neonatal porcine islet xenografts.

Xenotransplantation 2006 Nov;13(6):547-59

Department of Surgery, Dentistry Pharmacy Centre, Surgical-Medical Research Institute, University of Alberta, Edmonton, AB, Canada.

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http://dx.doi.org/10.1111/j.1399-3089.2006.00349.xDOI Listing
November 2006

Effect of prolonged in vitro exposure to high glucose on neonatal porcine pancreatic islets.

J Endocrinol 2006 Oct;191(1):37-44

Department of Surgery, Surgical-Medical Research Institute, 1074 Dentistry Pharmacy Center, University of Alberta, Alberta, Edmonton, Canada.

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http://dx.doi.org/10.1677/joe.1.06812DOI Listing
October 2006

Long-term survival of neonatal porcine islets in nonhuman primates by targeting costimulation pathways.

Nat Med 2006 Mar 26;12(3):304-6. Epub 2006 Feb 26.

Emory Transplant Center, Department of Surgery, Emory University School of Medicine, 101 Woodruff Circle, Suite 5105, Atlanta, Georgia 30322, USA.

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http://www.nature.com/articles/nm1375
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http://dx.doi.org/10.1038/nm1375DOI Listing
March 2006

Expansion of mesenchymal stem cells from human pancreatic ductal epithelium.

Lab Invest 2006 Feb;86(2):141-53

Surgical-Medical Research Institute, University of Alberta, Edmonton, AB, Canada.

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http://dx.doi.org/10.1038/labinvest.3700377DOI Listing
February 2006

Development of an ectopic site for islet transplantation, using biodegradable scaffolds.

Tissue Eng 2005 Sep-Oct;11(9-10):1323-31

Surgical-Medical Research Institute, University of Alberta, Edmonton, AB, Canada.

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http://dx.doi.org/10.1089/ten.2005.11.1323DOI Listing
December 2005

Neonatal porcine Sertoli cells inhibit human natural antibody-mediated lysis.

Biol Reprod 2005 May 19;72(5):1224-31. Epub 2005 Jan 19.

Surgical-Medical Research Institute, University of Alberta, Edmonton, Alberta, Canada.

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http://dx.doi.org/10.1095/biolreprod.104.038315DOI Listing
May 2005

Reversal of diabetes in pancreatectomized pigs after transplantation of neonatal porcine islets.

Diabetes 2005 Apr;54(4):1032-9

Department of Surgery, University of Alberta, Edmonton, Alberta, Canada.

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http://dx.doi.org/10.2337/diabetes.54.4.1032DOI Listing
April 2005

Reassessment of the vascularization of renal subcapsular islet grafts.

Pancreas 2004 Oct;29(3):e59-63

Surgical-Medical Research Institute, University of Alberta, Edmonton, Alberta, Canada.

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http://dx.doi.org/10.1097/00006676-200410000-00014DOI Listing
October 2004

Porcine endogenous retroviral nucleic acid in peripheral tissues is associated with migration of porcine cells post islet transplant.

Am J Transplant 2004 Jul;4(7):1051-60

Surgical-Medical Research Institute, University of Alberta, Edmonton, Alberta, Canada.

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http://dx.doi.org/10.1111/j.1600-6143.2004.00460.xDOI Listing
July 2004

Stem cell-based approaches to solving the problem of tissue supply for islet transplantation in type 1 diabetes.

Int J Biochem Cell Biol 2004 Apr;36(4):667-83

Surgical-Medical Research Institute, University of Alberta, Room 1074, Dentistry/Pharmacy Building, Edmonton, Alta., Canada T6G 2N8.

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http://dx.doi.org/10.1016/j.biocel.2003.09.005DOI Listing
April 2004

Stem cells: a promising source of pancreatic islets for transplantation in type 1 diabetes.

Curr Top Dev Biol 2003 ;58:111-36

Surgical-Medical Research Institute, Rm. 1074 Dentistry/Pharmacy Bldg., University of Alberta Edmonton, AB, Canada T6G 2N8.

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http://dx.doi.org/10.1016/s0070-2153(03)58004-8DOI Listing
February 2004

Harnessing the immunomodulatory properties of Sertoli cells to enable xenotransplantation in type I diabetes.

Immunol Invest 2003 Nov;32(4):275-97

Surgical-Medical Research Institute, University of Alberta, Edmonton, Canada.

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http://dx.doi.org/10.1081/imm-120025106DOI Listing
November 2003

Long-term survival of neonatal porcine Sertoli cells in non-immunosuppressed rats.

Xenotransplantation 2003 Nov;10(6):577-86

Surgical-Medical Research Institute, University of Alberta, Edmonton, Canada.

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http://dx.doi.org/10.1034/j.1399-3089.2003.00059.xDOI Listing
November 2003

Percutaneous transhepatic pancreatic islet cell transplantation in type 1 diabetes mellitus: radiologic aspects.

Radiology 2003 Oct 27;229(1):165-70. Epub 2003 Aug 27.

Departments of Diagnostic Imaging, University of Alberta Hospital, 8440-112th Street, Edmonton, Alberta, Canada T6G 2B7.

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http://dx.doi.org/10.1148/radiol.2291021632DOI Listing
October 2003

Current status of islet cell transplantation.

Adv Surg 2003 ;37:253-82

Department of Surgery, University of Alberta, Edmonton, Alberta, Canada.

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October 2003

Immunization with streptozotocin-treated NOD mouse islets inhibits the onset of autoimmune diabetes in NOD mice.

J Autoimmun 2003 Aug;21(1):11-5

Surgical-Medical Research Institute, University of Alberta, 1074 B Dentistry/Pharmacy Building, Edmonton, AB, Canada T6G 2N8.

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http://dx.doi.org/10.1016/s0896-8411(03)00080-5DOI Listing
August 2003

Granzyme B: a natural born killer.

Immunol Rev 2003 Jun;193:31-8

Department of Surgery, University of Alberta, Edmonton, Alberta, Canada.

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http://dx.doi.org/10.1034/j.1600-065x.2003.00044.xDOI Listing
June 2003

The degree of phylogenetic disparity of islet grafts dictates the reliance on indirect CD4 T-cell antigen recognition for rejection.

Diabetes 2003 Jun;52(6):1433-40

Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, 4200 East 9th Avenue, Denver, CO 80262, USA.

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http://dx.doi.org/10.2337/diabetes.52.6.1433DOI Listing
June 2003

Immunoprotection of rat islet xenografts by cotransplantation with sertoli cells and a single injection of antilymphocyte serum.

Transplantation 2003 May;75(9):1594-6

Surgical-Medical Research Institute, University of Alberta, Edmonton, Canada.

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http://dx.doi.org/10.1097/01.TP.0000058748.00707.88DOI Listing
May 2003

Development of an immunoprivileged site to prolong islet allograft survival.

Cell Transplant 2002 ;11(6):547-52

Surgical-Medical Research Institute, University of Alberta, Edmonton, Canada.

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April 2003

Survival and metabolic function of syngeneic rat islet grafts transplanted in the omental pouch.

Am J Transplant 2003 Mar;3(3):281-5

Surgical-Medical Research Institute, University of Alberta, Edmonton, Canada.

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http://dx.doi.org/10.1034/j.1600-6143.2003.00049.xDOI Listing
March 2003

Human ABO blood group is important in survival and function of porcine working hearts.

Am J Transplant 2003 Mar;3(3):286-93

The Division of Cardiac Surgery, Department of Surgery, and The Surgical Medical Research Institute, University of Alberta, Edmonton, Alberta, Canada.

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http://dx.doi.org/10.1034/j.1600-6143.2003.00055.xDOI Listing
March 2003

Long-term survival of intratesticular porcine islets in nonimmunosuppressed beagles.

Transplantation 2003 Mar;75(5):613-8

Department of Surgery, Carolinas Medical Center, Charlotte, NC, USA.

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http://dx.doi.org/10.1097/01.TP.0000052376.89400.8DDOI Listing
March 2003

Development of an in vivo model to study testicular morphogenesis.

J Androl 2002 Sep-Oct;23(5):635-44

Surgical-Medical Research Institute and the Department of Surgery, University of Alberta, Edmonton, Canada.

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February 2003

Portal venous pressure changes after sequential clinical islet transplantation.

Transplantation 2002 Oct;74(7):913-5

Department of Surgical and Clinical Sciences (Surgery), Royal Infirmary, Edinburgh, Scotland.

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http://dx.doi.org/10.1097/00007890-200210150-00002DOI Listing
October 2002

Successful islet transplantation: continued insulin reserve provides long-term glycemic control.

Diabetes 2002 Jul;51(7):2148-57

Department of Medicine, Clinical Islet Transplant Program, University of Alberta and Capital Health Authority, 2000 College Plaza, 8215 112th Street, Edmonton, Alberta, Canada T6G 2C8.

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http://dx.doi.org/10.2337/diabetes.51.7.2148DOI Listing
July 2002