Gregory Reaman

Gregory Reaman

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Gregory Reaman

Gregory Reaman

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Cancer drugs approved for use in children: Impact of legislative initiatives and future opportunities.

Pediatr Blood Cancer 2019 Aug 30;66(8):e27809. Epub 2019 May 30.

Oncology Center for Excellence, U.S. Food and Drug Administration, Silver Spring, Maryland.

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http://dx.doi.org/10.1002/pbc.27809DOI Listing
August 2019

Interventions for cisplatin-induced hearing loss in children and adolescents with cancer.

Lancet Child Adolesc Health 2019 Aug 31;3(8):578-584. Epub 2019 May 31.

Division of Haematology and Oncology, The Hospital for Sick Children, Toronto, ON, Canada. Electronic address:

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http://dx.doi.org/10.1016/S2352-4642(19)30115-4DOI Listing
August 2019

Pediatric Development of Molecularly Targeted Oncology Drugs.

Clin Pharmacol Ther 2018 08 11;104(2):384-389. Epub 2017 Dec 11.

Office of Hematology and Oncology Products, Office of New Drugs, Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland, USA.

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http://dx.doi.org/10.1002/cpt.942DOI Listing
August 2018

Prevention of cisplatin-induced hearing loss in children: Informing the design of future clinical trials.

Cancer Med 2018 May 30. Epub 2018 May 30.

Division of Hematology, Oncology, and Blood and Bone Marrow Transplantation, Children's Hospital Los Angeles, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.

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http://dx.doi.org/10.1002/cam4.1563DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6051159PMC
May 2018

U.S. Food and Drug Administration approval summary: Eltrombopag for the treatment of pediatric patients with chronic immune (idiopathic) thrombocytopenia.

Pediatr Blood Cancer 2017 Dec 19;64(12). Epub 2017 Jun 19.

Office of Hematology and Oncology Products, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, Maryland.

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http://dx.doi.org/10.1002/pbc.26657DOI Listing
December 2017

Commentary on Heath et al.

Clin Trials 2017 12 2;14(6):572-574. Epub 2017 Aug 2.

3 Oncology Center of Excellence, US Food and Drug Administration, Silver Spring, MD, USA.

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http://dx.doi.org/10.1177/1740774517723308DOI Listing
December 2017

Modernizing Clinical Trial Eligibility: Recommendations of the American Society of Clinical Oncology-Friends of Cancer Research Minimum Age Working Group.

J Clin Oncol 2017 Nov 2;35(33):3781-3787. Epub 2017 Oct 2.

Lia Gore, Children's Hospital Colorado and University of Colorado School of Medicine, Aurora, CO; S. Percy Ivy, National Cancer Institute, Bethesda; Martha Donoghue and Gregory Reaman, US Food and Drug Administration, Silver Spring, MD; Frank M. Balis, Children's Hospital of Philadelphia, Philadelphia, PA; Eric Rubin, Merck Research Laboratories, Kenilworth, NJ; Katherine Thornton, Dana-Farber Cancer Institute, Boston, MA; Samantha Roberts, Friends of Cancer Research and Genentech; Nancy Goodman, Kids v Cancer, Washington, DC; Suanna Bruinooge and Caroline Schenkel, ASCO, Alexandria, VA; and Jennifer Ersek, Levine Cancer Institute, Charlotte, NC.

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http://ascopubs.org/doi/10.1200/JCO.2017.74.4144
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http://dx.doi.org/10.1200/JCO.2017.74.4144DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5692725PMC
November 2017

Bridging Adult Experience to Pediatrics in Oncology Drug Development.

J Clin Pharmacol 2017 Oct;57 Suppl 10:S129-S135

Office of Clinical Pharmacology, Office of Translational Sciences, Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, MD, USA.

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http://dx.doi.org/10.1002/jcph.910DOI Listing
October 2017

Enrolling Adolescents in Disease/Target-Appropriate Adult Oncology Clinical Trials of Investigational Agents.

Clin Cancer Res 2017 Jan 25;23(1):9-12. Epub 2016 Oct 25.

Office of Hematology and Oncology Products, U.S. Food and Drug Administration, Silver Spring, Maryland.

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http://dx.doi.org/10.1158/1078-0432.CCR-16-1367DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5217169PMC
January 2017

Advancing a comprehensive cancer care agenda for children and their families: Institute of Medicine Workshop highlights and next steps.

CA Cancer J Clin 2016 09 4;66(5):398-407. Epub 2016 May 4.

Pediatric Palliative Care Service, Department of Psychosocial Oncology and Palliative Care, Dana-Farber Cancer Institute, Boston, MA.

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http://dx.doi.org/10.3322/caac.21347DOI Listing
September 2016

An FDA oncology view of juvenile animal studies in support of initial pediatric trials for anticancer drugs.

Regul Toxicol Pharmacol 2016 Aug 4;79:142-143. Epub 2016 Mar 4.

US Food and Drug Administration, Center for Drug Evaluation and Research, Office of Hematology and Oncology Products, 10903 New Hampshire Ave, Silver Spring, MD 20903, United States.

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http://dx.doi.org/10.1016/j.yrtph.2016.03.001DOI Listing
August 2016

Successful Integration of Cooperative Groups: The Origin of the Children's Oncology Group.

Authors:
Gregory H Reaman

Am Soc Clin Oncol Educ Book 2012 :149-51

From the Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, MD, and the Division of Oncology, Children's National Medical Center, Washington, DC 20010.

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http://dx.doi.org/10.14694/EdBook_AM.2012.32.149DOI Listing
April 2016

Regulatory perspective on minimal residual disease flow cytometry testing in multiple myeloma.

Cytometry B Clin Cytom 2016 Jan 25;90(1):73-80. Epub 2015 Jul 25.

Center for Drug Evaluation and Research (CDER) and Center for Devices and Radiologic Health (CDRH), Food and Drug Administration (FDA).

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http://doi.wiley.com/10.1002/cyto.b.21268
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http://dx.doi.org/10.1002/cyto.b.21268DOI Listing
January 2016

Feasibility Study of a Novel Experimental Induction Protocol Combining B43-PAP (Anti-CD19) Immunotoxin With Standard Induction Chemotherapy in Children and Adolescents With Relapsed B-Lineage ALL: A Report From the Children's Oncology Group.

J Immunother 2015 Sep;38(7):299-305

*Department of Pediatric Hematology-Oncology, Children's National Medical Center, George Washington University School of Medicine and Public Health, Washington, DC †Clinical Investigations Branch, Cancer Therapy Evaluation Program, NCI, Bethesda ¶¶Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, MD ‡Keck School of Medicine, University of Southern California ¶Division of Hematology-Oncology, Children's Hospital Los Angeles, Los Angeles §Children's Oncology Group, Arcadia ‡‡Department of Pediatrics, City of Hope National Medical Center, Duarte, CA ∥Department of Biostatistics and Bioinformatics, Emory University ∥∥Aflac Cancer and Blood Disorder Center, Children's Healthcare of Atlanta/Emory University, Atlanta, GA #Department of Pediatrics, University of Minnesota Medical School, Minneapolis, MN **Department of Pediatrics, Seattle Children's Hospital, University of Washington, Seattle, WA ††Pediatric Hematology-Oncology, C.S. Mott Children's Hospital, Ann Arbor, MI §§Division of Pediatrics, Children's Cancer Hospital at the University of Texas M.D. Anderson Cancer Center, Houston, TX.

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http://dx.doi.org/10.1097/CJI.0000000000000088DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4536569PMC
September 2015

Medication Exposures and Subsequent Development of Ewing Sarcoma: A Review of FDA Adverse Event Reports.

Sarcoma 2015 7;2015:948159. Epub 2015 May 7.

U.S. Public Health Service Commissioned Corps, Office of Translational Sciences, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, White Oak Bldg. 22, Room 3410, 10903 New Hampshire Avenue, Silver Spring, MD 20993, USA.

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http://dx.doi.org/10.1155/2015/948159DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4439508PMC
June 2015

Remaining challenges in childhood cancer and newer targeted therapeutics.

Pediatr Clin North Am 2015 Feb 18;62(1):301-12. Epub 2014 Oct 18.

Office of Hematology and Oncology Products, OND, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, White Oak Building 22, Room 2202, 10903 New Hampshire Avenue, Silver Spring, MD 20993, USA.

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http://dx.doi.org/10.1016/j.pcl.2014.09.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4336187PMC
February 2015

CD22ΔE12 as a molecular target for corrective repair using RNA trans-splicing: anti-leukemic activity of a rationally designed RNA trans-splicing molecule.

Integr Biol (Camb) 2015 Feb;7(2):237-49

Children's Center for Cancer and Blood Diseases, Children's Hospital Los Angeles (CHLA), Mailstop 160, 4650 Sunset Boulevard, Smith Research Tower Suite 300-316, Los Angeles, CA 90027, USA.

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http://dx.doi.org/10.1039/c4ib00221kDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4373651PMC
February 2015

Pharmacokinetic and pharmacodynamic properties of calaspargase pegol Escherichia coli L-asparaginase in the treatment of patients with acute lymphoblastic leukemia: results from Children's Oncology Group Study AALL07P4.

J Clin Oncol 2014 Dec 27;32(34):3874-82. Epub 2014 Oct 27.

Anne L. Angiolillo, Reuven J. Schore, Ashley R. Lane, and Gregory H. Reaman, Children's National Medical Center, Washington, DC; Meenakshi Devidas, Colleges of Medicine, Public Health and Health Professions, University of Florida; Charlotte Wood and Hao W. Zheng, Children's Oncology Group, Gainesville, FL; Michael J. Borowitz, Johns Hopkins Medical Institutions, Baltimore; Taha Keilani, Sigma-Tau Pharmaceuticals, Gaithersburg, MD; Andrew J. Carroll, University of Alabama at Birmingham, Birmingham, AL; Julie M. Gastier-Foster and Nyla A. Heerema, Ohio State University Wexner Medical Center; Julie M. Gastier-Foster, Ohio State University College of Medicine and Nationwide Children's Hospital, Columbus, OH; Mignon L. Loh, University of California at San Francisco, San Francisco, CA; Peter C. Adamson, Children's Hospital of Philadelphia, Philadelphia, PA; Brent Wood, University of Washington, Seattle, WA; Elizabeth A. Raetz and William L. Carroll, New York University Cancer Institute, New York University Langone Medical Center, New York, NY; Naomi J. Winick, University of Texas Southwestern Medical Center, Dallas, TX; and Stephen P. Hunger, Children's Hospital Colorado and University of Colorado School of Medicine, Aurora, CO.

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http://dx.doi.org/10.1200/JCO.2014.55.5763DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4239306PMC
December 2014

The Children's Oncology Group Childhood Cancer Research Network (CCRN): case catchment in the United States.

Cancer 2014 Oct 29;120(19):3007-15. Epub 2014 May 29.

Division of Epidemiology and Clinical Research, Department of Pediatrics, University of Minnesota, Minneapolis, Minnesota.

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http://dx.doi.org/10.1002/cncr.28813DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4287245PMC
October 2014

International patterns of childhood chronic myeloid leukemia: comparisons between the United States and resource-restricted nations.

Pediatr Blood Cancer 2014 Oct 29;61(10):1774-8. Epub 2014 Jun 29.

Division of Pediatric Hematology/Oncology, University of Minnesota Children's Hospital, Minneapolis, Minnesota; Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota.

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http://dx.doi.org/10.1002/pbc.25120DOI Listing
October 2014

Pharmacokinetics and pharmacogenomics of daunorubicin in children: a report from the Children's Oncology Group.

Cancer Chemother Pharmacol 2014 Oct 14;74(4):831-8. Epub 2014 Aug 14.

Texas Children's Cancer Center, Baylor College of Medicine, 1102 Bates Ave., Suite 1570, Houston, TX, 77030, USA.

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http://dx.doi.org/10.1007/s00280-014-2535-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4282931PMC
October 2014

Declining childhood and adolescent cancer mortality.

Cancer 2014 Aug 22;120(16):2497-506. Epub 2014 May 22.

Cancer Therapy Evaluation Program, National Cancer Institute, Bethesda, Maryland.

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http://dx.doi.org/10.1002/cncr.28748DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4136455PMC
August 2014

DrugPath: a database for academic investigators to match oncology molecular targets with drugs in development.

Cancer Chemother Pharmacol 2014 May 25;73(5):1089-93. Epub 2014 Mar 25.

Cancer Center and Departments of Cell Biology and Biochemistry, Pediatrics, and Internal Medicine, School of Medicine, Texas Tech University Health Sciences Center, 3601 4th St, STOP 9445, Lubbock, TX, 79430, USA.

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http://link.springer.com/10.1007/s00280-014-2433-9
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http://dx.doi.org/10.1007/s00280-014-2433-9DOI Listing
May 2014

Pediatric oncology drug shortages: a multifaceted problem.

Pediatrics 2014 Mar 2;133(3):e728-9. Epub 2014 Feb 2.

Office of Pediatric Therapeutics, Office of the Commissioner, Food and Drug Administrations; and.

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http://dx.doi.org/10.1542/peds.2013-4018DOI Listing
March 2014

Patient-perceived facilitators in the transition of care for young adult survivors of childhood cancer.

Pediatr Blood Cancer 2013 Aug 25;60(8):1365-8. Epub 2013 Feb 25.

Center for Cancer and Blood Disorders, Children's National Medical Center, Washington, District of Columbia, USA.

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http://doi.wiley.com/10.1002/pbc.24494
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http://dx.doi.org/10.1002/pbc.24494DOI Listing
August 2013

The impact of the written request process on drug development in childhood cancer.

Pediatr Blood Cancer 2013 Apr 17;60(4):531-7. Epub 2013 Jan 17.

Office of Hematology and Oncology Products, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, Maryland 20901-0002, USA.

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http://dx.doi.org/10.1002/pbc.24346DOI Listing
April 2013

Implementation of multi-site neurocognitive assessments within a pediatric cooperative group: can it be done?

Pediatr Blood Cancer 2012 Sep 3;59(3):536-9. Epub 2012 May 3.

Department of Pediatrics, University of Texas Health Science Center, San Antonio, USA.

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http://doi.wiley.com/10.1002/pbc.24139
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http://dx.doi.org/10.1002/pbc.24139DOI Listing
September 2012

CD22 Exon 12 deletion is a characteristic genetic defect of therapy-refractory clones in paediatric acute lymphoblastic leukaemia.

Br J Haematol 2012 Jan 21;156(1):89-98. Epub 2011 Oct 21.

Division of Hematology-Oncology, Department of Pediatrics, University of Southern California Keck School of Medicine, Los Angeles, CA, USA.

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http://dx.doi.org/10.1111/j.1365-2141.2011.08901.xDOI Listing
January 2012

Childhood cancer survivorship educational resources in North American hematology/oncology fellowship training programs: a survey study.

Authors:
Gregory H Reaman

Pediatr Blood Cancer 2011 Dec 9;57(7):1097. Epub 2011 Jul 9.

Division of Oncology, Center for Cancer and Blood Disorders, Children's National Medical Center, 111 Michigan Ave, NW, Washington, DC 20010, USA.

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http://dx.doi.org/10.1002/pbc.23243DOI Listing
December 2011

What price cure?

Pediatr Blood Cancer 2011 Dec;57(6):908-9

Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02215, USA.

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http://dx.doi.org/10.1002/pbc.23302DOI Listing
December 2011

Feasibility of neonatal dried blood spot retrieval amid evolving state policies (2009-2010): a Children's Oncology Group study.

Paediatr Perinat Epidemiol 2011 Nov 10;25(6):549-58. Epub 2011 Aug 10.

Division of Pediatric Epidemiology and Clinical Research, Department of Pediatrics, University of Minnesota, Minneapolis, 55455, USA.

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http://dx.doi.org/10.1111/j.1365-3016.2011.01228.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3664237PMC
November 2011

Health care reform 2010: expected favorable impact on childhood cancer patients and survivors.

Cancer J 2010 Nov-Dec;16(6):554-62

Department of Pediatrics, City of Hope National Medical Center, Duarte, Los Angeles, USA.

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http://dx.doi.org/10.1097/PPO.0b013e3181feee83DOI Listing
April 2011

Outcomes for children and adolescents with cancer: challenges for the twenty-first century.

J Clin Oncol 2010 May 19;28(15):2625-34. Epub 2010 Apr 19.

Cancer Therapy Evaluation Program, National Cancer Institute, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1200/JCO.2009.27.0421DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2881732PMC
May 2010

A phase II study of Campath-1H in children with relapsed or refractory acute lymphoblastic leukemia: a Children's Oncology Group report.

Pediatr Blood Cancer 2009 Dec;53(6):978-83

Division of Oncology, Children's National Medical Center, Washington, District of Columbia 20010, USA.

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http://dx.doi.org/10.1002/pbc.22209DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3120889PMC
December 2009

The ALARA concept in pediatric oncology.

Pediatr Radiol 2009 Nov 30;39(11):1142-6. Epub 2009 Sep 30.

Department of Radiology, Children's Hospital Boston, Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1007/s00247-009-1404-5DOI Listing
November 2009

Late effects in long-term survivors after treatment for childhood acute leukemia.

Clin Pediatr (Phila) 2009 Jul 4;48(6):601-8. Epub 2009 Mar 4.

Department of Pediatric Hematology-Oncology, Children's National Medical Center, Washington, DC,USA.

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http://dx.doi.org/10.1177/0009922809332680DOI Listing
July 2009

Analysis of infectious complications in infants with acute lymphoblastic leukemia treated on the Children's Cancer Group Protocol 1953: a report from the Children's Oncology Group.

J Pediatr Hematol Oncol 2009 Jun;31(6):398-405

National Cancer Institute, NIH, NCI-IRB, 9030 Old Georgetown Road, Building 82, Room 215, MSC 8200, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1097/MPH.0b013e3181a6dec0DOI Listing
June 2009

Novel targeted drug therapies for the treatment of childhood acute leukemia.

Expert Rev Hematol 2009 Apr;2(9):145

Departments of Oncology and Pediatrics, Sidney Kimmel Comprehensive Cancer, Center and Johns Hopkins University, School of Medicine, 1650 Orleans Street, CRB1 Room 2M49, Baltimore, MD 21231, USA, Tel.: +1 410 955 8817, ,

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http://dx.doi.org/10.1586/ehm.09.1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2794143PMC
April 2009

What, why, and when we image: considerations for diagnostic imaging and clinical research in the Children's Oncology Group.

Authors:
Gregory H Reaman

Pediatr Radiol 2009 Feb 16;39 Suppl 1:S42-5. Epub 2008 Dec 16.

Children's National Medical Center, The George Washington University, Washington, DC 20010-2970, USA.

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http://dx.doi.org/10.1007/s00247-008-1065-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3987784PMC
February 2009

Prevention of hearing loss in children receiving cisplatin chemotherapy.

J Clin Oncol 2009 Jan 8;27(2):317-8; author reply 318-9. Epub 2008 Dec 8.

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http://dx.doi.org/10.1200/JCO.2008.20.1160DOI Listing
January 2009

A national approach to evaluating delays in diagnosis and treatment: potential implications for age related and geo-political differences in access to care and outcome in children and adolescents with cancer.

Authors:
Gregory H Reaman

Pediatr Blood Cancer 2008 Oct;51(4):447-8

The George Washington University, School of Medicine and Health Sciences, Children's National Medical Center, Washington, DC, USA.

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http://doi.wiley.com/10.1002/pbc.21662
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http://dx.doi.org/10.1002/pbc.21662DOI Listing
October 2008

Progress in the curative treatment of childhood hematologic malignancies.

J Natl Cancer Inst 2008 Sep 9;100(18):1271-3. Epub 2008 Sep 9.

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http://dx.doi.org/10.1093/jnci/djn306DOI Listing
September 2008

Signposts along the NIH roadmap for reengineering clinical research: lessons from the Clinical Research Networks initiative.

Arch Intern Med 2008 Sep;168(17):1919-25

Department of Family and Community Medicine, University of New Mexico, Albuquerque, NM 87131, USA.

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http://dx.doi.org/10.1001/archinte.168.17.1919DOI Listing
September 2008

Phase 2 study of docetaxel in the treatment of childhood refractory acute leukemias: a Children's Oncology Group report.

Pediatr Blood Cancer 2008 Mar;50(3):533-6

Childrens Hospital Los Angeles, Los Angeles, California, USA.

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http://dx.doi.org/10.1002/pbc.21313DOI Listing
March 2008

Survival among children with medulloblastoma in Greece: gains from transition to chemotherapy and socio-economic differentials.

Eur J Cancer Prev 2007 Oct;16(5):460-5

Hematology-Oncology Unit, First Department of Pediatrics, University of Athens, Aghia Sophia Children's Hospital, Athens, Greece.

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http://dx.doi.org/10.1097/01.cej.0000243848.74609.9aDOI Listing
October 2007

Hypertension and prehypertension in long-term survivors of childhood and adolescent cancer.

Pediatr Blood Cancer 2007 Jul;49(1):79-83

Department of Pediatric Hematology-Oncology, Children's National Medical Center, 111 Michigan Avenue NW, Washington, District of Columbia 20010-2970, USA.

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http://dx.doi.org/10.1002/pbc.20886DOI Listing
July 2007

The problems and promise of central pathology review: development of a standardized procedure for the Children's Oncology Group.

Pediatr Dev Pathol 2007 May-Jun;10(3):199-207

Children's Hospital of Pittsburgh and University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.

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http://dx.doi.org/10.2350/06-06-0121.1DOI Listing
July 2007

Phase I trial of oral fenretinide in children with high-risk solid tumors: a report from the Children's Oncology Group (CCG 09709).

J Clin Oncol 2006 Jul;24(21):3423-30

Children's Hospital Los Angeles and the Department Pediatrics, University of Southern California Keck School of Medicine, Los Angeles, USA.

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http://dx.doi.org/10.1200/JCO.2005.03.9271DOI Listing
July 2006