Publications by authors named "Gregorio Aluffi"

2 Publications

  • Page 1 of 1

CT Simplified Radiomic Approach to Assess the Metastatic Ductal Adenocarcinoma of the Pancreas.

Cancers (Basel) 2021 Apr 13;13(8). Epub 2021 Apr 13.

Unit of General and Pancreatic Surgery, The Pancreas Institute, Policlinico GB Rossi, University of Verona, 37129 Verona, Italy.

The aim of this study was to perform a simplified radiomic analysis of pancreatic ductal adenocarcinoma based on qualitative and quantitative tumor features and to compare the results between metastatic and non-metastatic patients. A search of our radiological, surgical, and pathological databases identified 1218 patients with a newly diagnosed pancreatic ductal adenocarcinoma who were referred to our Institution between January 2014 and December 2018. Computed Tomography (CT) examinations were reviewed analyzing qualitative and quantitative features. Two hundred eighty-eight patients fulfilled the inclusion criteria and were included in this study. Overall, metastases were present at diagnosis in 86/288 patients, while no metastases were identified in 202/288 patients. Ill-defined margins and a hypodense appearance on portal-phase images were significantly more common among patients with metastases compared to non-metastatic patients ( < 0.05). Metastatic tumors showed a significantly larger size and significantly lower arterial index, perfusion index, and permeability index compared to non-metastatic tumors ( < 0.05). In the management of pancreatic ductal adenocarcinoma, early detection and correct staging are key elements. The study of computerized tomography characteristics of pancreatic ductal adenocarcinoma showed substantial differences, both qualitative and quantitative, between metastatic and non-metastatic disease.
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http://dx.doi.org/10.3390/cancers13081843DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8069159PMC
April 2021

Liver Tumor Burden in Pancreatic Neuroendocrine Tumors: CT Features and Texture Analysis in the Prediction of Tumor Grade and F-FDG Uptake.

Cancers (Basel) 2020 Jun 7;12(6). Epub 2020 Jun 7.

Department of Radiology, G.B. Rossi Hospital, University of Verona, 37134 Verona, Italy.

Pancreatic neuroendocrine tumors (p-NETs) are a rare group of neoplasms that often present with liver metastases. Histological characteristics, metabolic behavior, and liver tumor burden (LTB) are important prognostic factors. In this study, the usefulness of texture analysis of liver metastases in evaluating the biological aggressiveness of p-NETs was assessed. Fifty-six patients with liver metastases from p-NET were retrospectively enrolled. Qualitative and quantitative CT features of LTB were evaluated. Histogram-derived parameters of liver metastases were calculated and correlated with the tumor grade (G) and F-fluorodeoxyglucose (F-FDG) standardized uptake value (SUV). Arterial relative enhancement was inversely related with G (-0.37, = 0.006). Different metastatic spread patterns of LTB were not associated with histological grade. Arterial was significantly correlated to G (-0.368, = 0.038) and to Ki67 percentage (-0.421, = 0.018). The ROC curve for the Arterial reported an area under the curve (AUC) of 0.736 (95% confidence interval 0.545-0.928, = 0.035) in the identification of G1-2 tumors. Arterial values were correlated to G (0.346, = 0.005) and Ki67 levels (0.383, = 0.033). Arterial values were directly correlated with the SUV (0.449, = 0.047) which was inversely correlated with Arterial (-0.499, = 0.025). Skewness and kurtosis reported no significant correlations. In conclusion, histogram-derived parameters may predict adverse histological features and metabolic behavior of p-NET liver metastases.
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http://dx.doi.org/10.3390/cancers12061486DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7352332PMC
June 2020