Graziano Lolli

Graziano Lolli

UNVERIFIED PROFILE

Are you Graziano Lolli?   Register this Author

Register author
Graziano Lolli

Graziano Lolli

Publications by authors named "Graziano Lolli"

Are you Graziano Lolli?   Register this Author

31Publications

364Reads

41Profile Views

Identification of compounds inhibiting prion replication and toxicity by removing PrP from the cell surface.

J Neurochem 2019 Jul 2. Epub 2019 Jul 2.

Dulbecco Telethon Laboratory of Prions and Amyloids, Department of Cellular, Computational and Integrative Biology (CIBIO), University of Trento, Trento, Italy.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/jnc.14805DOI Listing
July 2019

Inhibitory Properties of ATP-Competitive Coumestrol and Boldine Are Correlated to Different Modulations of CK2 Flexibility.

J Nat Prod 2019 Apr 6;82(4):1014-1018. Epub 2019 Mar 6.

Department of Cellular, Computational and Integrative Biology - CIBIO , University of Trento , Via Sommarive 9 , 38123 Povo (TN) , Italy.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/acs.jnatprod.8b00889DOI Listing
April 2019

Screening Approaches for Targeting Ribonucleoprotein Complexes: A New Dimension for Drug Discovery.

SLAS Discov 2019 Mar 7;24(3):314-331. Epub 2019 Jan 7.

2 University of Trento, HTS Core Facility, Department of Cellular, Computational and Integrative Biology (CIBIO), Trento, Italy.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/2472555218818065DOI Listing
March 2019

Insight into GFPmut2 pH Dependence by Single Crystal Microspectrophotometry and X-ray Crystallography.

J Phys Chem B 2018 Dec 17;122(49):11326-11337. Epub 2018 Sep 17.

Dipartimento di Scienze Chimiche , Università degli Studi di Padova and Istituto di Chimica Biomolecolare, Consiglio Nazionale delle Ricerche , 35131 Padua , Italy.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/acs.jpcb.8b07260DOI Listing
December 2018

Structural Analysis of Small-Molecule Binding to the BAZ2A and BAZ2B Bromodomains.

ChemMedChem 2018 07 21;13(14):1479-1487. Epub 2018 Jun 21.

Department of Biochemistry, University of Zürich, Winterthurerstrasse 190, 8057, Zürich, Switzerland.

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1002/cmdc.201800234
Publisher Site
http://dx.doi.org/10.1002/cmdc.201800234DOI Listing
July 2018

Discovery of BAZ2A bromodomain ligands.

Eur J Med Chem 2017 Oct 12;139:564-572. Epub 2017 Aug 12.

Department of Biochemistry, University of Zürich, Winterthurerstrasse 190, CH-8057 Zürich, Switzerland. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ejmech.2017.08.028DOI Listing
October 2017

Discovery of Inhibitors of Four Bromodomains by Fragment-Anchored Ligand Docking.

J Chem Inf Model 2017 10 18;57(10):2584-2597. Epub 2017 Sep 18.

Department of Biochemistry, University of Zürich , CH-8057, Zürich, Switzerland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/acs.jcim.7b00336DOI Listing
October 2017

Characterization of the oligomeric states of the CK2 αβ holoenzyme in solution.

Biochem J 2017 07 6;474(14):2405-2416. Epub 2017 Jul 6.

Department of Chemical Sciences, University of Padua, via Marzolo 1, Padova 35131, Italy

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1042/BCJ20170189DOI Listing
July 2017

Derivatives of 3-Amino-2-methylpyridine as BAZ2B Bromodomain Ligands: In Silico Discovery and in Crystallo Validation.

J Med Chem 2016 11 26;59(21):9919-9927. Epub 2016 Oct 26.

Department of Biochemistry, University of Zürich , Winterthurerstrasse 190, CH-8057, Zürich, Switzerland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/acs.jmedchem.6b01258DOI Listing
November 2016

The "Gatekeeper" Residue Influences the Mode of Binding of Acetyl Indoles to Bromodomains.

J Med Chem 2016 Apr 30;59(7):3087-97. Epub 2016 Mar 30.

Department of Chemistry and ‡Department of Biochemistry, University of Zürich , Winterthurerstrasse 190, CH-8057 Zürich, Switzerland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/acs.jmedchem.5b01757DOI Listing
April 2016

High-Throughput Fragment Docking into the BAZ2B Bromodomain: Efficient in Silico Screening for X-Ray Crystallography.

ACS Chem Biol 2016 Mar;11(3):800-7

Department of Biochemistry, University of Zürich , Winterthurerstrasse 190, CH-8057, Zürich, Switzerland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/acschembio.5b00914DOI Listing
March 2016

The STAS domain of mammalian SLC26A5 prestin harbours an anion-binding site.

Biochem J 2016 Feb 3;473(4):365-70. Epub 2015 Dec 3.

Department of Chemical Sciences, University of Padua, via Marzolo 1, 35131 Padua, Italy

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1042/BJ20151089DOI Listing
February 2016

An inhibitor's-eye view of the ATP-binding site of CDKs in different regulatory states.

ACS Chem Biol 2014 Jun 10;9(6):1251-6. Epub 2014 Apr 10.

Laboratory of Molecular Biophysics, Department of Biochemistry, Oxford University , South Parks Road, Oxford OX1 3QU, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/cb500135fDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4068217PMC
June 2014

The lysine-specific demethylase 1 is a novel substrate of protein kinase CK2.

Biochim Biophys Acta 2014 Apr 31;1844(4):722-9. Epub 2014 Jan 31.

Department of Biomedical Sciences and CNR Institute of Neurosciences, Viale G. Colombo, University of Padova, 35131 Padova, Italy. Electronic address:

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S15709639140001
Publisher Site
http://dx.doi.org/10.1016/j.bbapap.2014.01.014DOI Listing
April 2014

Active form of the protein kinase CK2 α2β2 holoenzyme is a strong complex with symmetric architecture.

ACS Chem Biol 2014 Feb 11;9(2):366-71. Epub 2013 Nov 11.

Department of Chemical Sciences, University of Padua , via Marzolo 1, 35131 Padova, Italy.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/cb400771yDOI Listing
February 2014

Different orientations of low-molecular-weight fragments in the binding pocket of a BRD4 bromodomain.

Acta Crystallogr D Biol Crystallogr 2013 Oct 20;69(Pt 10):2161-4. Epub 2013 Sep 20.

Department of Chemical Sciences, University of Padova, Via Marzolo 1, 35131 Padova, Italy.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1107/S090744491301994XDOI Listing
October 2013

Inhibition of protein kinase CK2 by flavonoids and tyrphostins. A structural insight.

Biochemistry 2012 Aug 25;51(31):6097-107. Epub 2012 Jul 25.

Venetian Institute of Molecular Medicine (VIMM), Padova, Italy, Via G. Orus 2 35129 Padova, Italy.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/bi300531cDOI Listing
August 2012

Structural determinants of protein kinase CK2 regulation by autoinhibitory polymerization.

ACS Chem Biol 2012 Jul 20;7(7):1158-63. Epub 2012 Apr 20.

Department of Chemical Sciences, University of Padua, Padova, Italy.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/cb300054nDOI Listing
July 2012

Structural and functional analysis of the flexible regions of the catalytic α-subunit of protein kinase CK2.

J Struct Biol 2012 Feb 13;177(2):382-91. Epub 2011 Dec 13.

Department of Biological Chemistry, University of Padua, viale G. Colombo 3, 35121 Padova, Italy.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jsb.2011.12.007DOI Listing
February 2012

Structural and functional determinants of protein kinase CK2α: facts and open questions.

Mol Cell Biochem 2011 Oct 8;356(1-2):67-73. Epub 2011 Jul 8.

Venetian Institute for Molecular Medicine, via Orus 2, 35129 Padova, Italy.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s11010-011-0939-6DOI Listing
October 2011

Structure and single crystal spectroscopy of Green Fluorescent Proteins.

Biochim Biophys Acta 2011 Jun 19;1814(6):824-33. Epub 2010 Oct 19.

Department of Biochemistry and Molecular Biology, University of Parma, Viale Usberti 23/A, 43124 Parma, Italy.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bbapap.2010.10.002DOI Listing
June 2011

Structural dissection of cyclin dependent kinases regulation and protein recognition properties.

Authors:
Graziano Lolli

Cell Cycle 2010 Apr 15;9(8):1551-61. Epub 2010 Apr 15.

Venetian Institute of Molecular Medicine, University of Padua, Padua, Italy.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4161/cc.9.8.11195DOI Listing
April 2010

Binding to DNA of the RNA-polymerase II C-terminal domain allows discrimination between Cdk7 and Cdk9 phosphorylation.

Authors:
Graziano Lolli

Nucleic Acids Res 2009 Mar 9;37(4):1260-8. Epub 2009 Jan 9.

Laboratory of Molecular Biophysics, Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/nar/gkn1061DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2651791PMC
March 2009

The structure of P-TEFb (CDK9/cyclin T1), its complex with flavopiridol and regulation by phosphorylation.

EMBO J 2008 Jul 19;27(13):1907-18. Epub 2008 Jun 19.

Laboratory of Molecular Biophysics, Department of Biochemistry, University of Oxford, Oxford, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/emboj.2008.121DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2486423PMC
July 2008

Recognition of Cdk2 by Cdk7.

Proteins 2007 Jun;67(4):1048-59

Laboratory of Molecular Biophysics, Department of Biochemistry, University of Oxford, Oxford OX1 3QU, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/prot.21370DOI Listing
June 2007

CAK-Cyclin-dependent Activating Kinase: a key kinase in cell cycle control and a target for drugs?

Cell Cycle 2005 Apr 16;4(4):572-7. Epub 2005 Apr 16.

Laboratory of Molecular Biophysics, Department of Biochemistry, University of Oxford, Oxford, UK.

View Article

Download full-text PDF

Source
April 2005

The crystal structure of human CDK7 and its protein recognition properties.

Structure 2004 Nov;12(11):2067-79

Laboratory of Molecular Biophysics, Department of Biochemistry, University of Oxford, Rex Richards Building, Oxford, OX1 3QU, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.str.2004.08.013DOI Listing
November 2004

GroEL from the psychrophilic bacterium Pseudoalteromonas haloplanktis TAC 125: molecular characterization and gene cloning.

Extremophiles 2003 Feb 1;7(1):17-28. Epub 2002 Oct 1.

Dipartimento di Chimica Organica e Biochimica, Università di Napoli Federico II, Complesso Universitario di Monte Sant'Angelo, Via Cynthia 4, 80126 Naples, Italy.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00792-002-0291-6DOI Listing
February 2003