Publications by authors named "Grazia Saturno"

14Publications

Author Correction: Lysyl oxidase drives tumour progression by trapping EGF receptors at the cell surface.

Authors:
HaoRan Tang Leo Leung Grazia Saturno Amaya Viros Duncan Smith Gianpiero Di Leva Eamonn Morrison Dan Niculescu-Duvaz Filipa Lopes Louise Johnson Nathalie Dhomen Caroline Springer Richard Marais

Nat Commun 2019 Jul 18;10(1):3151. Epub 2019 Jul 18.

Molecular Oncology Group, Cancer Research UK Manchester Institute, University of Manchester, Manchester, M20 4BX, UK.

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July 2019

Anti-metastatic Inhibitors of Lysyl Oxidase (LOX): Design and Structure-Activity Relationships.

Authors:
Leo Leung Dan Niculescu-Duvaz Deborah Smithen Filipa Lopes Cedric Callens Robert McLeary Grazia Saturno Lawrence Davies Mohammed Aljarah Michael Brown Louise Johnson Alfonso Zambon Tim Chambers Delphine Ménard Natasha Bayliss Ruth Knight Laura Fish Rae Lawrence Mairi Challinor HaoRan Tang Richard Marais Caroline Springer

J Med Chem 2019 06 23;62(12):5863-5884. Epub 2019 May 23.

Cancer Research UK Centre for Cancer Therapeutics , The Institute of Cancer Research , 15 Cotswold Road , London SM2 5NG , United Kingdom.

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June 2019

Lysyl oxidase drives tumour progression by trapping EGF receptors at the cell surface.

Authors:
HaoRan Tang Leo Leung Grazia Saturno Amaya Viros Duncan Smith Gianpiero Di Leva Eamonn Morrison Dan Niculescu-Duvaz Filipa Lopes Louise Johnson Nathalie Dhomen Caroline Springer Richard Marais

Nat Commun 2017 04 18;8:14909. Epub 2017 Apr 18.

Molecular Oncology Group, Cancer Research UK Manchester Institute, University of Manchester, Manchester M20 4BX, UK.

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April 2017

Paradox-Breaking RAF Inhibitors that Also Target SRC Are Effective in Drug-Resistant BRAF Mutant Melanoma.

Authors:
Maria Romina Girotti Filipa Lopes Natasha Preece Dan Niculescu-Duvaz Alfonso Zambon Lawrence Davies Steven Whittaker Grazia Saturno Amaya Viros Malin Pedersen Bart M J M Suijkerbuijk Delphine Menard Robert McLeary Louise Johnson Laura Fish Sarah Ejiama Berta Sanchez-Laorden Juliane Hohloch Neil Carragher Kenneth Macleod Garry Ashton Anna A Marusiak Alberto Fusi John Brognard Margaret Frame Paul Lorigan Richard Marais Caroline Springer

Cancer Cell 2017 03;31(3):466

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March 2017

Application of Sequencing, Liquid Biopsies, and Patient-Derived Xenografts for Personalized Medicine in Melanoma.

Authors:
Maria Romina Girotti Gabriela Gremel Rebecca Lee Elena Galvani Dominic Rothwell Amaya Viros Amit Kumar Mandal Kok Haw Jonathan Lim Grazia Saturno Simon J Furney Franziska Baenke Malin Pedersen Jane Rogan Jacqueline Swan Matthew Smith Alberto Fusi Deemesh Oudit Nathalie Dhomen Ged Brady Paul Lorigan Caroline Dive Richard Marais

Cancer Discov 2016 Mar 29;6(3):286-99. Epub 2015 Dec 29.

Molecular Oncology Group, Cancer Research UK Manchester Institute, Manchester, United Kingdom.

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March 2016

Targeting the LOX/hypoxia axis reverses many of the features that make pancreatic cancer deadly: inhibition of LOX abrogates metastasis and enhances drug efficacy.

Authors:
Bryan W Miller Jennifer P Morton Mark Pinese Grazia Saturno Nigel B Jamieson Ewan McGhee Paul Timpson Joshua Leach Lynn McGarry Emma Shanks Peter Bailey David Chang Karin Oien Saadia Karim Amy Au Colin Steele Christopher Ross Carter Colin McKay Kurt Anderson Thomas R Jeffry Evans Richard Marais Caroline Springer Andrew Biankin Janine T Erler Owen J Sansom

EMBO Mol Med 2015 Aug;7(8):1063-76

Cancer Research UK Beatson Institute Garscube Estate, Glasgow, UK

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August 2015

Paradox-breaking RAF inhibitors that also target SRC are effective in drug-resistant BRAF mutant melanoma.

Authors:
Maria Romina Girotti Filipa Lopes Natasha Preece Dan Niculescu-Duvaz Alfonso Zambon Lawrence Davies Steven Whittaker Grazia Saturno Amaya Viros Malin Pedersen Bart M J M Suijkerbuijk Delphine Menard Robert McLeary Louise Johnson Laura Fish Sarah Ejiama Berta Sanchez-Laorden Juliane Hohloch Neil Carragher Kenneth Macleod Garry Ashton Anna A Marusiak Alberto Fusi John Brognard Margaret Frame Paul Lorigan Richard Marais Caroline Springer

Cancer Cell 2015 Jan 11;27(1):85-96. Epub 2014 Dec 11.

Cancer Research UK Cancer Therapeutics Unit, The Institute of Cancer Research, London SM2 5NG, UK. Electronic address:

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January 2015

No longer an untreatable disease: how targeted and immunotherapies have changed the management of melanoma patients.

Authors:
Maria Romina Girotti Grazia Saturno Paul Lorigan Richard Marais

Mol Oncol 2014 Sep 15;8(6):1140-58. Epub 2014 Aug 15.

Molecular Oncology Group, Cancer Research UK Manchester Institute, Manchester, UK. Electronic address:

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September 2014

BRAF inhibitors induce metastasis in RAS mutant or inhibitor-resistant melanoma cells by reactivating MEK and ERK signaling.

Authors:
Berta Sanchez-Laorden Amaya Viros Maria Romina Girotti Malin Pedersen Grazia Saturno Alfonso Zambon Dan Niculescu-Duvaz Samra Turajlic Andrew Hayes Martin Gore James Larkin Paul Lorigan Martin Cook Caroline Springer Richard Marais

Sci Signal 2014 Mar 25;7(318):ra30. Epub 2014 Mar 25.

1Molecular Oncology Group, Cancer Research UK Manchester Institute, The University of Manchester, Manchester M20 4BX, UK.

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March 2014

Combining trail with PI3 kinase or HSP90 inhibitors enhances apoptosis in colorectal cancer cells via suppression of survival signaling.

Authors:
Grazia Saturno Melanie Valenti Alexis De Haven Brandon George V Thomas Suzanne Eccles Paul A Clarke Paul Workman

Oncotarget 2013 Aug;4(8):1185-98

Cancer Research UK Cancer Therapeutics Unit, Division of Cancer Therapeutics, The Institute of Cancer Research, London, UK.

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August 2013

Expression of serine/threonine protein-kinases and related factors in normal monkey and human retinas: the mechanistic understanding of a CDK2 inhibitor induced retinal toxicity.

Authors:
Grazia Saturno Manuela Pesenti Cristiano Cavazzoli Anna Rossi Anna M Giusti Berthold Gierke Michael Pawlak Miro Venturi

Toxicol Pathol 2007 Dec;35(7):972-83

Nerviano Medical Sciences (NMS), Nerviano, MI, Italy.

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December 2007

Assessing and managing toxicities induced by kinase inhibitors.

Authors:
Raffaella E Castoldi Giulia Pennella Grazia S Saturno Pietro Grossi Marco Brughera Miro Venturi

Curr Opin Drug Discov Devel 2007 Jan;10(1):53-7

Nerviano Medical Sciences, Preclinical Development, Attrition Reducing Technologies - Analytical Biology Group, Milan, Italy.

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January 2007

An in vivo and in vitro comparison of CYP gene induction in mice using liver slices and quantitative RT-PCR.

Authors:
Marcella Martignoni Ruben de Kanter Pietro Grossi Grazia Saturno Elena Barbaria Mario Monshouwer

Toxicol In Vitro 2006 Feb 10;20(1):125-31. Epub 2005 Aug 10.

Preclinical Development, Nerviano Medical Sciences, Viale Pasteur 10, 20014 Nerviano (MI), Italy.

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February 2006

An in vivo and in vitro comparison of CYP induction in rat liver and intestine using slices and quantitative RT-PCR.

Authors:
Marcella Martignoni Ruben de Kanter Pietro Grossi Axel Mahnke Grazia Saturno Mario Monshouwer

Chem Biol Interact 2004 Dec;151(1):1-11

Preclinical Development, Nerviano Medical Science, Viale Pasteur 10, 20014 Nerviano (MI), Italy.

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December 2004