Grant S Stewart

Grant S Stewart

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Grant S Stewart

Publications by authors named "Grant S Stewart"

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Chromosome instability syndromes.

Nat Rev Dis Primers 2019 Sep 19;5(1):64. Epub 2019 Sep 19.

Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, UK.

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http://dx.doi.org/10.1038/s41572-019-0113-0DOI Listing
September 2019

Novel PNKP mutations causing defective DNA strand break repair and PARP1 hyperactivity in MCSZ.

Neurol Genet 2019 Apr 25;5(2):e320. Epub 2019 Mar 25.

Department of Genome Dynamics (I.K., H.H., K.W.C.), Institute of Molecular Genetics of the Czech Academy of Sciences, Czech Republic; Genome Damage and Stability Centre (H.H., K.W.C.), School of Life Sciences, University of Sussex, Falmer, Brighton, UK; Institute of Human Genetics (Y.L., B.W., G.Y.), University Medical Center Göttingen, Germany; Cologne Center for Genomics (J.A.), University of Cologne, Germany; Institute of Cancer and Genomic Sciences (J.J.R., G.S.S.), College of Medical and Dental Sciences, University of Birmingham, UK; and Division of Genetics (N.G.), Department of Pediatrics, All India Institute of Medical Sciences, New Delhi, India.

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http://dx.doi.org/10.1212/NXG.0000000000000320DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454307PMC
April 2019

MYBL2 Supports DNA Double Strand Break Repair in Hematopoietic Stem Cells.

Cancer Res 2018 10 6;78(20):5767-5779. Epub 2018 Aug 6.

Institute of Cancer and Genomic Sciences, College of Medical and Dental Sciences, University of Birmingham, Birmingham, United Kingdom.

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http://dx.doi.org/10.1158/0008-5472.CAN-18-0273DOI Listing
October 2018

Histone Methylation by SETD1A Protects Nascent DNA through the Nucleosome Chaperone Activity of FANCD2.

Mol Cell 2018 07 21;71(1):25-41.e6. Epub 2018 Jun 21.

Genome Stability and Human Disease Laboratory, Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham B15 2TT, UK. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2018.05.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6039718PMC
July 2018

Novel 3q27.2-qter deletion in a patient with Diamond-Blackfan anemia and immunodeficiency: Case report and review of literature.

Am J Med Genet A 2017 Jun 21;173(6):1514-1520. Epub 2017 Apr 21.

Department of Medical Genetics and Pediatrics, McGill University Health Centre, Montréal, Quebec, Canada.

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http://dx.doi.org/10.1002/ajmg.a.38208DOI Listing
June 2017

PRMT5-Dependent Methylation of the TIP60 Coactivator RUVBL1 Is a Key Regulator of Homologous Recombination.

Mol Cell 2017 Mar 23;65(5):900-916.e7. Epub 2017 Feb 23.

Institute of Cancer and Genomic Sciences, College of Medical and Dental Sciences, University of Birmingham, Birmingham B15 2TT, UK. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2017.01.019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5344794PMC
March 2017

Protection or resection: BOD1L as a novel replication fork protection factor.

Nucleus 2016 18;7(1):34-40. Epub 2016 Feb 18.

a Institute of Cancer and Genomic Studies , University of Birmingham , Birmingham , UK.

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http://dx.doi.org/10.1080/19491034.2016.1143183DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4916882PMC
December 2016

RNF168 and USP10 regulate topoisomerase IIα function via opposing effects on its ubiquitylation.

Nat Commun 2016 08 25;7:12638. Epub 2016 Aug 25.

Department of Medical Biophysics, Princess Margaret Cancer Centre, Ontario Cancer Institute, University Health Network, University of Toronto, Toronto, Ontario, Canada M5G 1L7.

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http://dx.doi.org/10.1038/ncomms12638DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5007378PMC
August 2016

Damaged replication forks tolerate USP7 to maintain genome stability.

Mol Cell Oncol 2016 Jan 6;3(1):e1063571. Epub 2015 Jul 6.

School of Cancer Sciences, University of Birmingham , Birmingham, UK.

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http://dx.doi.org/10.1080/23723556.2015.1063571DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4845244PMC
January 2016

Alchemix, p53 and topoisomerase.

Aging (Albany NY) 2015 Sep;7(9):601-2

School of Cancer Sciences, College of Medicine and Dentistry, University of Birmingham, Birmingham, U.K. B15 2TT.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4600614PMC
http://dx.doi.org/10.18632/aging.100803DOI Listing
September 2015

Activation of DNA Damage Response Pathways during Lytic Replication of KSHV.

Viruses 2015 Jun 5;7(6):2908-27. Epub 2015 Jun 5.

School of Cancer Sciences, the College of Medicine and Dentistry, University of Birmingham, Birmingham B15 2TT, UK.

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http://dx.doi.org/10.3390/v7062752DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4488719PMC
June 2015

BRCA2 and RAD51 promote double-strand break formation and cell death in response to gemcitabine.

Mol Cancer Ther 2014 Oct 22;13(10):2412-21. Epub 2014 Jul 22.

School of Cancer Sciences, University of Birmingham, Edgbaston, Birmingham, United Kingdom.

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http://dx.doi.org/10.1158/1535-7163.MCT-13-0862DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4185294PMC
October 2014

Reply: A single strand that links multiple neuropathologies in human disease.

Brain 2014 Apr 5;137(Pt 4):e267. Epub 2013 Aug 5.

School of Cancer Sciences, University of Birmingham, Birmingham, West Midlands, B15 2TT, UK.

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http://dx.doi.org/10.1093/brain/awt198DOI Listing
April 2014

RNF168 ubiquitylates 53BP1 and controls its response to DNA double-strand breaks.

Proc Natl Acad Sci U S A 2013 Dec 9;110(52):20982-7. Epub 2013 Dec 9.

Ontario Cancer Institute, University Health Network and Department of Medical Biophysics, University of Toronto, Toronto, M5G 2M9 ON, Canada.

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http://dx.doi.org/10.1073/pnas.1320302111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3876264PMC
December 2013

A nervous predisposition to unrepaired DNA double strand breaks.

DNA Repair (Amst) 2013 Aug 17;12(8):588-99. Epub 2013 May 17.

School of Cancer Sciences, College of Medicine and Dentistry, University of Birmingham, IBR West Extension, First Floor, Vincent Drive, Edgbaston, Birmingham B15 2TT, United Kingdom.

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http://dx.doi.org/10.1016/j.dnarep.2013.04.011DOI Listing
August 2013

A single strand that links multiple neuropathologies in human disease.

Brain 2013 Jan;136(Pt 1):14-27

School of Cancer Sciences, College of Medical and Dental Sciences, University of Birmingham, Birmingham B15 2TT, UK.

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http://dx.doi.org/10.1093/brain/aws310DOI Listing
January 2013

The demise of a TUDOR under stress opens a chromatin link to 53BP1.

Authors:
Grant S Stewart

EMBO J 2012 Apr 27;31(8):1847-9. Epub 2012 Mar 27.

School of Cancer Sciences, University of Birmingham, Birmingham, UK.

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http://dx.doi.org/10.1038/emboj.2012.78DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3343343PMC
April 2012

Genomic instability, defective spermatogenesis, immunodeficiency, and cancer in a mouse model of the RIDDLE syndrome.

PLoS Genet 2011 Apr 28;7(4):e1001381. Epub 2011 Apr 28.

Ontario Cancer Institute, University Health Network and Department of Medical Biophysics, University of Toronto, Toronto, Canada.

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http://dx.doi.org/10.1371/journal.pgen.1001381DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3084200PMC
April 2011

DNA double-strand break repair, immunodeficiency and the RIDDLE syndrome.

Expert Rev Clin Immunol 2011 Mar;7(2):169-85

School of Cancer Sciences, University of Birmingham, Vincent Drive, Edgbaston, Birmingham, B15 2TT, UK.

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http://www.tandfonline.com/doi/full/10.1586/eci.10.93
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http://dx.doi.org/10.1586/eci.10.93DOI Listing
March 2011

When cleavage is not attractive: non-catalytic inhibition of ubiquitin chains at DNA double-strand breaks by OTUB1.

DNA Repair (Amst) 2011 Feb 3;10(2):245-9. Epub 2010 Dec 3.

Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Headington, Oxford OX3 9DS, UK.

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https://linkinghub.elsevier.com/retrieve/pii/S15687864100038
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http://dx.doi.org/10.1016/j.dnarep.2010.11.004DOI Listing
February 2011

Adenovirus 12 E4orf6 inhibits ATR activation by promoting TOPBP1 degradation.

Proc Natl Acad Sci U S A 2010 Jul 21;107(27):12251-6. Epub 2010 Jun 21.

School of Cancer Sciences, College of Medical and Dental Sciences, University of Birmingham, Birmingham B15 2TT, United Kingdom.

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http://dx.doi.org/10.1073/pnas.0914605107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2901489PMC
July 2010

A PIAS-ed view of DNA double strand break repair focuses on SUMO.

DNA Repair (Amst) 2010 May 1;9(5):588-92. Epub 2010 Mar 1.

School of Cancer Sciences, University of Birmingham, Vincent Drive, Edgbaston, Birmingham, West Midlands B15 2TT, UK.

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http://dx.doi.org/10.1016/j.dnarep.2010.02.003DOI Listing
May 2010

53BP1-dependent robust localized KAP-1 phosphorylation is essential for heterochromatic DNA double-strand break repair.

Nat Cell Biol 2010 Feb 17;12(2):177-84. Epub 2010 Jan 17.

Genome Damage and Stability Centre, University of Sussex, East Sussex, BN1 9RQ, UK.

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http://www.nature.com/articles/ncb2017
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http://dx.doi.org/10.1038/ncb2017DOI Listing
February 2010

Mediator of DNA damage checkpoint 1 (MDC1) regulates mitotic progression.

J Biol Chem 2009 Dec 13;284(49):33939-48. Epub 2009 Oct 13.

Cancer Research-United Kingdom Institute for Cancer Sciences, University of Birmingham Medical School, Edgbaston, Birmingham B15 2TT, United Kingdom.

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http://dx.doi.org/10.1074/jbc.M109.009191DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2797164PMC
December 2009

Solving the RIDDLE of 53BP1 recruitment to sites of damage.

Authors:
Grant S Stewart

Cell Cycle 2009 May 4;8(10):1532-8. Epub 2009 May 4.

Cancer Research UK Institute for Cancer Studies, University of Birmingham, Edgbaston, Birmingham, UK.

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http://dx.doi.org/10.4161/cc.8.10.8351DOI Listing
May 2009

A role for E1B-AP5 in ATR signaling pathways during adenovirus infection.

J Virol 2008 Aug 14;82(15):7640-52. Epub 2008 May 14.

CR-UK Institute for Cancer Studies, The Medical School, The University of Birmingham, Edgbaston, Birmingham B15 2TT, United Kingdom.

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http://dx.doi.org/10.1128/JVI.00170-08DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2493339PMC
August 2008

Constitutive phosphorylation of MDC1 physically links the MRE11-RAD50-NBS1 complex to damaged chromatin.

J Cell Biol 2008 Apr 14;181(2):227-40. Epub 2008 Apr 14.

Institute of Veterinary Biochemistry and Molecular Biology, University of Zürich, 8057 Zürich, Switzerland.

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http://dx.doi.org/10.1083/jcb.200709008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2315671PMC
April 2008

RIDDLE immunodeficiency syndrome is linked to defects in 53BP1-mediated DNA damage signaling.

Proc Natl Acad Sci U S A 2007 Oct 16;104(43):16910-5. Epub 2007 Oct 16.

Cancer Research UK, Institute for Cancer Studies, Birmingham University, Vincent Drive, Edgbaston, Birmingham, United Kingdom.

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http://dx.doi.org/10.1073/pnas.0708408104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2040433PMC
October 2007

The APC/C and CBP/p300 cooperate to regulate transcription and cell-cycle progression.

Nature 2005 Dec;438(7068):690-5

Cancer Research UK Institute for Cancer Studies, The Medical School, The University of Birmingham, Edgbaston, Birmingham B15 2TT, UK.

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http://dx.doi.org/10.1038/nature04151DOI Listing
December 2005

Human Claspin works with BRCA1 to both positively and negatively regulate cell proliferation.

Proc Natl Acad Sci U S A 2004 Apr 19;101(17):6484-9. Epub 2004 Apr 19.

Verna and Marrs McLean Department of Biochemistry, Baylor College of Medicine, Houston, TX 77030, USA.

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http://dx.doi.org/10.1073/pnas.0401847101DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC404071PMC
April 2004

MDC1 is a mediator of the mammalian DNA damage checkpoint.

Nature 2003 Feb;421(6926):961-6

Verna & Mars McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, Texas 77030, USA.

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http://download.bioon.com.cn/upload/month_0912/20091218_1439
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http://www.nature.com/doifinder/10.1038/nature01446
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http://dx.doi.org/10.1038/nature01446DOI Listing
February 2003