Publications by authors named "Graham S Baldwin"

87Publications

Inhibition of PAK1 suppresses pancreatic cancer by stimulation of anti-tumour immunity through down-regulation of PD-L1.

Cancer Lett 2020 03 16;472:8-18. Epub 2019 Dec 16.

Department of Surgery, University of Melbourne, Austin Health, Heidelberg, Victoria, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.canlet.2019.12.020DOI Listing
March 2020

PAK inhibition by PF-3758309 enhanced the sensitivity of multiple chemotherapeutic reagents in patient-derived pancreatic cancer cell lines.

Am J Transl Res 2019 15;11(6):3353-3364. Epub 2019 Jun 15.

Department of Surgery, University of Melbourne, Austin Health Studley Road, Heidelberg, Victoria 3084, Australia.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6614655PMC
June 2019

Antitumor effects of all-trans retinoic acid and its synergism with gemcitabine are associated with downregulation of p21-activated kinases in pancreatic cancer.

Am J Physiol Gastrointest Liver Physiol 2019 05 7;316(5):G632-G640. Epub 2019 Mar 7.

Department of Surgery, University of Melbourne, Austin Health, Heidelberg, Melbourne, Victoria , Australia.

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https://www.physiology.org/doi/10.1152/ajpgi.00344.2018
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http://dx.doi.org/10.1152/ajpgi.00344.2018DOI Listing
May 2019

Preconditioning against renal ischaemia reperfusion injury: the failure to translate to the clinic.

J Nephrol 2019 Aug 11;32(4):539-547. Epub 2019 Jan 11.

Department of Surgery, Austin Health, The University of Melbourne, Studley Rd., Heidelberg, VIC, 3084, Australia.

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http://dx.doi.org/10.1007/s40620-019-00582-6DOI Listing
August 2019

p21-activated kinase signalling in pancreatic cancer: New insights into tumour biology and immune modulation.

World J Gastroenterol 2018 Sep;24(33):3709-3723

Department of Surgery, University of Melbourne, Melbourne 3084, Australia.

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http://dx.doi.org/10.3748/wjg.v24.i33.3709DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6127653PMC
September 2018

Zinc preconditioning protects against renal ischaemia reperfusion injury in a preclinical sheep large animal model.

Biometals 2018 10 4;31(5):821-834. Epub 2018 Jul 4.

The University of Melbourne Department of Surgery, Austin Health, Studley Rd., Heidelberg, VIC, 3084, Australia.

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http://dx.doi.org/10.1007/s10534-018-0125-3DOI Listing
October 2018

Zinc ion dyshomeostasis increases resistance of prostate cancer cells to oxidative stress via upregulation of HIF1α.

Oncotarget 2018 Feb 3;9(9):8463-8477. Epub 2018 Jan 3.

Department of Surgery, University of Melbourne, Austin Health, Heidelberg, Victoria, 3084, Australia.

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http://dx.doi.org/10.18632/oncotarget.23893DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5823553PMC
February 2018

Oral trivalent bismuth ions decrease, and trivalent indium or ruthenium ions increase, intestinal tumor burden in Apc mice.

Metallomics 2018 01;10(1):194-200

University of Melbourne Department of Surgery, Austin Health, Heidelberg, Victoria, Australia.

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http://xlink.rsc.org/?DOI=C7MT00272F
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http://dx.doi.org/10.1039/c7mt00272fDOI Listing
January 2018

Complexes of gastrin with In, Ru or Ga ions are not recognised by the cholecystokinin 2 receptor.

J Biol Inorg Chem 2017 Oct 12;22(7):999-1006. Epub 2017 Jul 12.

Department of Surgery, Austin Health, University of Melbourne, Level 8, Lance Townsend Building, Studley Road, Melbourne, VIC, 3084, Australia.

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http://dx.doi.org/10.1007/s00775-017-1478-8DOI Listing
October 2017

Depletion of p21-activated kinase 1 up-regulates the immune system of APC mice and inhibits intestinal tumorigenesis.

BMC Cancer 2017 Jun 19;17(1):431. Epub 2017 Jun 19.

Department of Surgery, University of Melbourne, Austin Health, Studley Rd, Heidelberg, VIC, 3084, Australia.

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http://dx.doi.org/10.1186/s12885-017-3432-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5477105PMC
June 2017

Progastrin: a potential predictive marker of liver metastasis in colorectal cancer.

Int J Colorectal Dis 2017 Jul 21;32(7):1061-1064. Epub 2017 Apr 21.

The University of Melbourne Department of Surgery, Austin Health, Heidelberg, Victoria, Australia.

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http://dx.doi.org/10.1007/s00384-017-2822-8DOI Listing
July 2017

Inhibition of group 1 p21-activated kinases suppresses pancreatic stellate cell activation and increases survival of mice with pancreatic cancer.

Int J Cancer 2017 05 7;140(9):2101-2111. Epub 2017 Feb 7.

Department of Surgery, University of Melbourne. Austin Health, Melbourne, VIC, Australia.

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http://dx.doi.org/10.1002/ijc.30615DOI Listing
May 2017

Zinc Ions Mediate Gastrin Expression, Proliferation, and Migration Downstream of the Cholecystokinin-2 Receptor.

Endocrinology 2016 Dec 31;157(12):4706-4719. Epub 2016 Oct 31.

Department of Surgery, University of Melbourne, Austin Health, Heidelberg 3084, Victoria, Australia.

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http://dx.doi.org/10.1210/en.2016-1270DOI Listing
December 2016

Glaucarubinone Combined with Gemcitabine Improves Pancreatic Cancer Survival in an Immunocompetent Orthotopic Murine Model.

J Invest Surg 2016 Dec 30;29(6):366-372. Epub 2016 Mar 30.

a Department of Surgery , University of Melbourne, Austin Health , Melbourne , Victoria , Australia.

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http://dx.doi.org/10.3109/08941939.2016.1160167DOI Listing
December 2016

FRAX597, a PAK1 inhibitor, synergistically reduces pancreatic cancer growth when combined with gemcitabine.

BMC Cancer 2016 Jan 16;16:24. Epub 2016 Jan 16.

Department of Surgery, Austin Health, University of Melbourne, Heidelberg, VIC, Australia.

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http://dx.doi.org/10.1186/s12885-016-2057-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4715347PMC
January 2016

Tyrosine modification increases the affinity of gastrin for ferric ions.

Springerplus 2015 24;4:815. Epub 2015 Dec 24.

Department of Surgery, Austin Health, The University of Melbourne, Heidelberg, VIC 3084 Australia.

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http://link.springer.com/content/pdf/10.1186%2Fs40064-015-16
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http://www.springerplus.com/content/4/1/815
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http://dx.doi.org/10.1186/s40064-015-1622-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4690827PMC
January 2016

Retro-inverso forms of gastrin5-12 are as biologically active as glycine-extended gastrin in vitro but not in vivo.

Peptides 2015 Dec 22;74:16-22. Epub 2015 Oct 22.

Department of Surgery, University of Melbourne, Austin Health, Lance Townsend Building, Level 8, Studley Road, Heidelberg, Victoria 3084 Australia. Electronic address:

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http://dx.doi.org/10.1016/j.peptides.2015.09.012DOI Listing
December 2015

High Affinity Binding of Indium and Ruthenium Ions by Gastrins.

PLoS One 2015 12;10(10):e0140126. Epub 2015 Oct 12.

Molecular and Environmental Science Research Group Department of Geological Sciences, 114 Science Place, University of Saskatchewan, Saskatoon, S7N 5E2, Canada.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0140126PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4601796PMC
June 2016

Activation by zinc of the human gastrin gene promoter in colon cancer cells in vitro and in vivo.

Metallomics 2015 Oct 25;7(10):1390-8. Epub 2015 Sep 25.

The Department of Surgery, University of Melbourne, Austin Health, Studley Rd, Heidelberg, Victoria 3084, Australia.

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http://dx.doi.org/10.1039/c5mt00147aDOI Listing
October 2015

The role of p21-activated kinases in pancreatic cancer.

Pancreas 2015 Apr;44(3):363-9

From the Department of Surgery, University of Melbourne, Austin Health, Heidelberg, Melbourne, Victoria, Australia.

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http://dx.doi.org/10.1097/MPA.0000000000000276DOI Listing
April 2015

HIF1α expression under normoxia in prostate cancer--which pathways to target?

J Urol 2015 Mar 19;193(3):763-70. Epub 2014 Oct 19.

Department of Surgery, University of Melbourne, Melbourne, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.juro.2014.10.085DOI Listing
March 2015

Glaucarubinone inhibits colorectal cancer growth by suppression of hypoxia-inducible factor 1α and β-catenin via a p-21 activated kinase 1-dependent pathway.

Biochim Biophys Acta 2015 Jan 22;1853(1):157-65. Epub 2014 Oct 22.

Department of Surgery, University of Melbourne, Austin Health, Melbourne, Victoria 3084, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.bbamcr.2014.10.013DOI Listing
January 2015

Increased gastrin gene expression provides a physiological advantage to mice under hypoxic conditions.

Am J Physiol Gastrointest Liver Physiol 2015 Jan 13;308(2):G76-84. Epub 2014 Nov 13.

Department of Surgery, University of Melbourne, Austin Health, Melbourne, Victoria, Australia

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http://dx.doi.org/10.1152/ajpgi.00344.2014DOI Listing
January 2015

Identification of binding sites for C-terminal pro-gastrin-releasing peptide (GRP)-derived peptides in renal cell carcinoma: a potential target for future therapy.

BJU Int 2015 May 26;115(5):829-38. Epub 2015 Jan 26.

Department of Surgery, Austin Health, University of Melbourne, Melbourne, Victoria, Australia.

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http://dx.doi.org/10.1111/bju.12886DOI Listing
May 2015

Gastrin mediates resistance to hypoxia-induced cell death in xenografts of the human colorectal cancer cell line LoVo.

Biochim Biophys Acta 2014 Nov 3;1843(11):2471-80. Epub 2014 Jul 3.

The University of Melbourne Department of Surgery, Austin Health, Heidelberg, Victoria, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.bbamcr.2014.06.016DOI Listing
November 2014

Normoxic regulation of HIF-1α in prostate cancer.

Nat Rev Urol 2014 Jul 1;11(7):419. Epub 2014 Jul 1.

Department of Surgery Heidelberg, Victoria 3084, Australia.

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http://dx.doi.org/10.1038/nrurol.2013.110-c2DOI Listing
July 2014

Demonstration and biological significance of a gastrin-P21-activated kinase 1 feedback loop in colorectal cancer cells.

Physiol Rep 2014 Jun 24;2(6). Epub 2014 Jun 24.

Department of Surgery, University of Melbourne, Austin Health, Melbourne, Victoria, Australia.

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http://dx.doi.org/10.14814/phy2.12048DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4208650PMC
June 2014

Expression and function of gastrin-releasing peptide (GRP) in normal and cancerous urological tissues.

BJU Int 2014 Mar;113 Suppl 2:40-7

Department of Surgery, Austin Health, Melbourne, VIC, Australia; Department of Urology, University of Melbourne, Austin Health, Melbourne, VIC, Australia.

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http://dx.doi.org/10.1111/bju.12594DOI Listing
March 2014

Glaucarubinone and gemcitabine synergistically reduce pancreatic cancer growth via down-regulation of P21-activated kinases.

Cancer Lett 2014 May 31;346(2):264-72. Epub 2014 Jan 31.

Department of Surgery, University of Melbourne, Austin Health, Melbourne, Victoria 3084, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.canlet.2014.01.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7681251PMC
May 2014

Zinc ions upregulate the hormone gastrin via an E-box motif in the proximal gastrin promoter.

J Mol Endocrinol 2014 Feb 20;52(1):29-42. Epub 2013 Dec 20.

Department of Surgery, Austin Health, The University of Melbourne, Studley Road, Heidelberg, Victoria 3084, Australia.

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http://dx.doi.org/10.1530/JME-13-0162DOI Listing
February 2014

Activation of Src family tyrosine kinases by ferric ions.

Biochim Biophys Acta 2014 Mar 12;1844(3):487-96. Epub 2013 Dec 12.

Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Parkville, Victoria, Australia.

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http://dx.doi.org/10.1016/j.bbapap.2013.12.004DOI Listing
March 2014

The C-terminal flanking peptide of progastrin induces gastric cell apoptosis and stimulates colonic cell division in vivo.

Peptides 2013 Aug 3;46:83-93. Epub 2013 Jun 3.

Department of Surgery, University of Melbourne, Austin Health, Lance Townsend Building, Lvl 8, Studley Road, Heidelberg, Victoria, Australia 3084.

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http://dx.doi.org/10.1016/j.peptides.2013.05.009DOI Listing
August 2013

p-21-Activated kinase 1 mediates gastrin-stimulated proliferation in the colorectal mucosa via multiple signaling pathways.

Am J Physiol Gastrointest Liver Physiol 2013 Mar 10;304(6):G561-7. Epub 2013 Jan 10.

Department of Surgery, University of Melbourne, Austin Health, Victoria, Australia.

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http://www.physiology.org/doi/10.1152/ajpgi.00218.2012
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http://dx.doi.org/10.1152/ajpgi.00218.2012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3602683PMC
March 2013

p21-activated kinases and gastrointestinal cancer.

Biochim Biophys Acta 2013 Jan 22;1833(1):33-9. Epub 2012 Oct 22.

Department of Surgery, University of Melbourne, Austin Health, Melbourne, Victoria, Australia.

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http://dx.doi.org/10.1016/j.bbamcr.2012.10.015DOI Listing
January 2013

Induction of gastrin expression in gastrointestinal cells by hypoxia or cobalt is independent of hypoxia-inducible factor (HIF).

Endocrinology 2012 Jul 16;153(7):3006-16. Epub 2012 May 16.

The University of Melbourne, Department of Surgery, Austin Health, Studley Road, Heidelberg, Victoria 3084, Australia.

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http://dx.doi.org/10.1210/en.2011-2069DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3380302PMC
July 2012

Pro-GRP-derived peptides are expressed in colorectal cancer cells and tumors and are biologically active in vivo.

Endocrinology 2012 Mar 27;153(3):1082-92. Epub 2011 Dec 27.

University of Melbourne Department of Surgery, Austin Health, Heidelberg, 3084 Victoria, Australia.

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https://academic.oup.com/endo/article-lookup/doi/10.1210/en.
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http://dx.doi.org/10.1210/en.2011-1875DOI Listing
March 2012

Bismuth ions inhibit the biological activity of non-amidated gastrins in vivo.

Biochem Pharmacol 2012 Feb 8;83(4):524-30. Epub 2011 Dec 8.

The University of Melbourne Department of Surgery, Austin Health, Heidelberg, Victoria, Australia.

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http://dx.doi.org/10.1016/j.bcp.2011.11.030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3259252PMC
February 2012

P-21 activated kinase 1 knockdown inhibits β-catenin signalling and blocks colorectal cancer growth.

Cancer Lett 2012 Apr 15;317(1):65-71. Epub 2011 Nov 15.

Department of Surgery, University of Melbourne, Austin Health, Melbourne, Victoria 3084, Australia.

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http://dx.doi.org/10.1016/j.canlet.2011.11.014DOI Listing
April 2012

Gastrin-deficient mice have disturbed hematopoiesis in response to iron deficiency.

Endocrinology 2011 Aug 7;152(8):3062-73. Epub 2011 Jun 7.

University of Melbourne Department of Surgery, Austin Health, Heidelberg, Victoria 3084, Australia.

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http://dx.doi.org/10.1210/en.2010-1474DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3138233PMC
August 2011

Gastrins, iron homeostasis and colorectal cancer.

Biochim Biophys Acta 2011 May 12;1813(5):889-95. Epub 2011 Feb 12.

The University of Melbourne Department of Surgery, Austin Health, Heidelberg, Victoria, Australia.

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https://linkinghub.elsevier.com/retrieve/pii/S01674889110005
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http://dx.doi.org/10.1016/j.bbamcr.2011.02.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3078979PMC
May 2011

Ferric ions inhibit proteolytic processing of progastrin.

Biochem Biophys Res Commun 2011 Jan 30;404(4):1083-7. Epub 2010 Dec 30.

The University of Melbourne, Department of Surgery, Austin Health, Heidelberg, 3084 Victoria, Australia.

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http://dx.doi.org/10.1016/j.bbrc.2010.12.117DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3046803PMC
January 2011

Gastrin increases its own synthesis in gastrointestinal cancer cells via the CCK2 receptor.

FEBS Lett 2010 Nov 8;584(21):4413-8. Epub 2010 Oct 8.

The University of Melbourne, Department of Surgery, Austin Health, Heidelberg, Victoria, Australia.

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http://dx.doi.org/10.1016/j.febslet.2010.09.046DOI Listing
November 2010

The C-terminal flanking peptide (CTFP) of progastrin inhibits apoptosis via a PI3-kinase-dependent pathway.

Regul Pept 2010 Dec 19;165(2-3):224-31. Epub 2010 Aug 19.

Department of Surgery, University of Melbourne Austin Health, Melbourne, Victoria 3084, Australia.

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http://dx.doi.org/10.1016/j.regpep.2010.08.005DOI Listing
December 2010

P21-activated kinase 1 stimulates colon cancer cell growth and migration/invasion via ERK- and AKT-dependent pathways.

Biochim Biophys Acta 2010 Sep 1;1803(9):1106-13. Epub 2010 Jun 1.

Department of Surgery, University of Melbourne, Austin Health, Melbourne, Victoria 3084, Australia.

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http://dx.doi.org/10.1016/j.bbamcr.2010.05.007DOI Listing
September 2010

Stimulation of proliferation in the colorectal mucosa by gastrin precursors is blocked by desferrioxamine.

Am J Physiol Gastrointest Liver Physiol 2010 Jul 15;299(1):G220-7. Epub 2010 Apr 15.

University of Melbourne Department of Surgery, Austin Health, Heidelberg 3084, Victoria, Australia.

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http://dx.doi.org/10.1152/ajpgi.00046.2010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2904120PMC
July 2010

Evolution of gastrointestinal hormones: the cholecystokinin/gastrin family.

Curr Opin Endocrinol Diabetes Obes 2010 Feb;17(1):77-88

Department of Surgery, The University of Melbourne, Austin Health, Heidelberg, Victoria, Australia.

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http://dx.doi.org/10.1097/MED.0b013e328334e535DOI Listing
February 2010

Gastrins, iron and colorectal cancer.

Authors:
Graham S Baldwin

Metallomics 2009 Sep 28;1(5):370-4. Epub 2009 Jul 28.

The University of Melbourne Department of Surgery, Austin Health, Studley Road, Heidelberg, Victoria 3084, Australia.

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http://dx.doi.org/10.1039/b909112mDOI Listing
September 2009

Definition of the residues required for the interaction between glycine-extended gastrin and transferrin in vitro.

FEBS J 2009 Sep 31;276(17):4866-74. Epub 2009 Jul 31.

Department of Surgery, University of Melbourne, Austin Health, Victoria, Australia.

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http://dx.doi.org/10.1111/j.1742-4658.2009.07186.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2749880PMC
September 2009

Expression of gastrin precursors by CD133-positive colorectal cancer cells is crucial for tumour growth.

Biochim Biophys Acta 2009 Mar 15;1793(3):477-88. Epub 2009 Jan 15.

Department of Surgery, Austin Health, University of Melbourne, Heidelberg 3084, Victoria, Australia.

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http://dx.doi.org/10.1016/j.bbamcr.2009.01.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2692632PMC
March 2009

Gastrin-releasing peptide: different forms, different functions.

Biofactors 2009 Jan-Feb;35(1):69-75

Department of Surgery, University of Melbourne, Austin Health, Melbourne, Victoria, Australia.

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http://dx.doi.org/10.1002/biof.10DOI Listing
May 2009

Peptide processing and biology in human disease.

Curr Opin Endocrinol Diabetes Obes 2009 Feb;16(1):79-85

University of Melbourne, Department of Surgery, Austin Health, Heidelberg, Victoria, Australia.

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http://dx.doi.org/10.1097/MED.0b013e3283202555DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2652633PMC
February 2009

Phosphorylation of cyclin-dependent kinase 2 peptides enhances metal binding.

Authors:
Graham S Baldwin

Biochem Biophys Res Commun 2009 Jan 25;379(1):151-4. Epub 2008 Dec 25.

Department of Surgery, The University of Melbourne, Austin Health, Studley Road, Heidelberg, Vic, Australia.

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http://dx.doi.org/10.1016/j.bbrc.2008.12.027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2680380PMC
January 2009

Interrelationships between circulating gastrin and iron status in mice and humans.

Am J Physiol Gastrointest Liver Physiol 2008 Oct 28;295(4):G855-61. Epub 2008 Aug 28.

Univ. of Melbourne Dept. of Surgery, Austin Health, Studley Rd., Heidelberg, Victoria 3084, Australia.

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http://dx.doi.org/10.1152/ajpgi.90359.2008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2575913PMC
October 2008

Tyrosine modification enhances metal-ion binding.

Biochem J 2008 Nov;416(1):77-84

The University of Melbourne Department of Surgery, Austin Health, Heidelberg, Victoria 3084, Australia.

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http://dx.doi.org/10.1042/BJ20081059DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2574882PMC
November 2008

Rho GTPases and p21-activated kinase in the regulation of proliferation and apoptosis by gastrins.

Int J Biochem Cell Biol 2008 15;40(10):2018-22. Epub 2008 May 15.

Department of Surgery, University of Melbourne, Austin Health, Studley Road, Heidelberg, Victoria 3084, Australia.

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http://dx.doi.org/10.1016/j.biocel.2008.05.002DOI Listing
October 2008

PAK1 interacts with beta-catenin and is required for the regulation of the beta-catenin signalling pathway by gastrins.

Biochim Biophys Acta 2008 Oct 3;1783(10):1943-54. Epub 2008 May 3.

Department of Surgery, University of Melbourne, Austin Health, Studley Road, Heidelberg, Melbourne, Victoria 3084, Australia.

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http://dx.doi.org/10.1016/j.bbamcr.2008.04.016DOI Listing
October 2008

Gastrin is not required for liver regeneration.

ANZ J Surg 2008 Jan-Feb;78(1-2):68-71

Department of Surgery, University of Melbourne, Austin Health, Heidelberg, Victoria, Australia.

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http://dx.doi.org/10.1111/j.1445-2197.2007.04360.xDOI Listing
March 2008

Preparation and properties of recombinant rat and human procholecystokinin(57-95).

Protein J 2008 Apr;27(3):186-91

Department of Surgery, Austin Health, University of Melbourne, Heidelberg, VIC 3084, Australia.

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http://dx.doi.org/10.1007/s10930-007-9122-zDOI Listing
April 2008

Involvement of G proteins of the Rho family in the regulation of Bcl-2-like protein expression and caspase 3 activation by Gastrins.

Cell Signal 2008 Jan 11;20(1):83-93. Epub 2007 Sep 11.

Department of Surgery, University of Melbourne, Austin Health, Melbourne, Victoria 3084, Australia.

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http://dx.doi.org/10.1016/j.cellsig.2007.08.018DOI Listing
January 2008

CCK receptors and cancer.

Curr Top Med Chem 2007 ;7(12):1232-8

University of Melbourne Department of Surgery, Austin Health, Melbourne, Victoria, Australia.

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http://dx.doi.org/10.2174/156802607780960492DOI Listing
September 2007

Recombinant C-terminal fragments of the gastrin-releasing peptide precursor are bioactive.

Cancer Lett 2007 Aug 29;254(1):87-93. Epub 2007 Mar 29.

University of Melbourne, Department of Surgery, Austin Health, Heidelberg, Melbourne, VIC, Australia.

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http://dx.doi.org/10.1016/j.canlet.2007.02.014DOI Listing
August 2007

Phylogenetic analysis of the sequences of gastrin-releasing peptide and its receptors: biological implications.

Regul Pept 2007 Oct 27;143(1-3):1-14. Epub 2007 Feb 27.

University of Melbourne, Department of Surgery, Austin Health, Studley Rd., Heidelberg, Victoria 3084, Australia.

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http://dx.doi.org/10.1016/j.regpep.2007.02.007DOI Listing
October 2007

C-terminal fragments of the gastrin-releasing peptide precursor stimulate cell proliferation via a novel receptor.

Endocrinology 2007 Mar 22;148(3):1330-9. Epub 2006 Nov 22.

Department of Surgery, Austin Health, Studley Road, Heidelberg, Victoria 3084, Australia.

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http://dx.doi.org/10.1210/en.2006-0466DOI Listing
March 2007

Production, secretion, and biological activity of the C-terminal flanking peptide of human progastrin.

Gastroenterology 2006 Nov 22;131(5):1463-74. Epub 2006 Aug 22.

Department of Surgery, University of Melbourne, Austin Health, Heidelberg, Victoria, Australia.

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http://dx.doi.org/10.1053/j.gastro.2006.08.040DOI Listing
November 2006

Circulating gastrin is increased in hemochromatosis.

FEBS Lett 2006 Nov 18;580(26):6195-8. Epub 2006 Oct 18.

University of Melbourne Department of Surgery, Austin Health, Level 8, Lance Townsend Building, Studley Road, Heidelberg, Vic. 3084, Australia.

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http://dx.doi.org/10.1016/j.febslet.2006.10.021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1780041PMC
November 2006

Gastrin-releasing peptide and cancer.

Biochim Biophys Acta 2006 Aug 31;1766(1):23-41. Epub 2006 Jan 31.

University of Melbourne, Department of Surgery, Austin Health, Studley Rd., Heidelberg, Victoria 3084, Australia.

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http://dx.doi.org/10.1016/j.bbcan.2006.01.003DOI Listing
August 2006

Mitogenic effects of both amidated and glycine-extended gastrin-releasing peptide in defunctioned and azoxymethane-treated rat colon in vivo.

Regul Pept 2006 Mar 16;134(1):9-16. Epub 2005 Nov 16.

University of Melbourne Departments of Surgery, Austin Health, Studley Rd., Heidelberg, Victoria 3084, Australia.

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http://dx.doi.org/10.1016/j.regpep.2005.10.001DOI Listing
March 2006

Synthesis, expression and biological activity of the prohormone for gastrin releasing peptide (ProGRP).

Endocrinology 2006 Jan 13;147(1):502-9. Epub 2005 Oct 13.

Department of Surgery, Austin Health, University of Melbourne, Heidelberg, Victoria 3084, Australia.

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http://dx.doi.org/10.1210/en.2005-0574DOI Listing
January 2006

Glycine-extended gastrin stimulates cell proliferation and migration through a Rho- and ROCK-dependent pathway, not a Rac/Cdc42-dependent pathway.

Am J Physiol Gastrointest Liver Physiol 2005 Sep 21;289(3):G478-88. Epub 2005 Apr 21.

Dept. of Surgery, Univ. of Melbourne, Austin Health, Studley Rd., Heidelberg, Victoria 3084, Australia.

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http://dx.doi.org/10.1152/ajpgi.00034.2005DOI Listing
September 2005

Signaling the junctions in gut epithelium.

Sci STKE 2005 Mar 29;2005(277):pe13. Epub 2005 Mar 29.

Functional Genomics Institute (IGF), Cellular and Molecular Oncology Department, CNRS UMR5203/INSERMU661-UM1-UM2, Montpellier, France.

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http://dx.doi.org/10.1126/stke.2772005pe13DOI Listing
March 2005

Stimulation of proliferation and migration of a colorectal cancer cell line by amidated and glycine-extended gastrin-releasing peptide via the same receptor.

Biochem Pharmacol 2004 Dec;68(11):2129-42

Departments of Surgery, Austin Hospital, University of Melbourne, Melbourne, Vic. 3084, Australia.

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http://dx.doi.org/10.1016/j.bcp.2004.08.009DOI Listing
December 2004

Biological activity and ferric ion binding of fragments of glycine-extended gastrin.

Biochemistry 2004 Sep;43(37):11853-61

The University of Melbourne Department of Surgery, Austin Health, Heidelberg, Victoria 3084, Australia.

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http://dx.doi.org/10.1021/bi0495984DOI Listing
September 2004

Identity and regulation of stored and secreted progastrin-derived peptides in sheep.

Endocrinology 2004 Nov 12;145(11):5129-40. Epub 2004 Aug 12.

Department of Surgery, University of Melbourne, Austin Health, Heidelberg, Victoria 3084, Australia.

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http://dx.doi.org/10.1210/en.2004-0912DOI Listing
November 2004

Gastrins, cholecystokinins and gastrointestinal cancer.

Biochim Biophys Acta 2004 Jul;1704(1):1-10

Department of Surgery, University of Melbourne, Austin Campus, A and RMC, Studley Road, Heidelberg, Melbourne, Victoria 3084, Australia.

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http://dx.doi.org/10.1016/j.bbcan.2004.01.004DOI Listing
July 2004

PPARalpha agonists stimulate progastrin production in human colorectal carcinoma cells.

Regul Pept 2004 Aug;120(1-3):243-51

Department of Surgery ARMC, University of Melbourne, Department of Surgery, Austin Health, Heidelberg, Victoria 3084, Australia.

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http://dx.doi.org/10.1016/j.regpep.2004.03.015DOI Listing
August 2004

Developmental expression and biological activity of gastrin-releasing peptide and its receptors in the kidney.

Am J Physiol Renal Physiol 2004 Sep 12;287(3):F578-85. Epub 2004 May 12.

University of Melbourne Department of Surgery, Austin Hospital, Melbourne, Victoria 3084, Australia.

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http://dx.doi.org/10.1152/ajprenal.00416.2003DOI Listing
September 2004

Properties of the complex between recombinant human progastrin and ferric ions.

Authors:
Graham S Baldwin

Protein J 2004 Jan;23(1):65-70

University of Melbourne, Department of Surgery, Austin Campus, Austin, Australia.

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http://dx.doi.org/10.1023/b:jopc.0000016259.59562.6cDOI Listing
January 2004

A novel effect of bismuth ions: selective inhibition of the biological activity of glycine-extended gastrin.

J Biol Chem 2004 Jan 6;279(4):2453-60. Epub 2003 Oct 6.

Department of Surgery, University of Melbourne, Austin Campus, ARMC, Heidelberg, Victoria 3084, Australia.

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http://dx.doi.org/10.1074/jbc.M309806200DOI Listing
January 2004

Adherens junctions and tight junctions are regulated via different pathways by progastrin in epithelial cells.

J Cell Sci 2003 Apr;116(Pt 7):1187-97

Laboratoire de Signalisation Cellulaire Normale et Tumorale, EA MNRT 2995, Faculté de Pharmacie, 15 Avenue C. Flahault, 34093 Montpellier, France.

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http://dx.doi.org/10.1242/jcs.00321DOI Listing
April 2003

Preparation of biologically active recombinant human progastrin(1-80).

J Protein Chem 2002 Oct;21(7):465-71

University of Melbourne Department of Surgery, Austin and Repatriation Medical Centre, Melbourne, Victoria, Australia.

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http://dx.doi.org/10.1023/a:1021399003934DOI Listing
October 2002

Ferric ions are essential for the biological activity of the hormone glycine-extended gastrin.

J Biol Chem 2002 Dec 20;277(50):48602-9. Epub 2002 Sep 20.

University of Melbourne Department of Surgery, Austin Campus, ARMC, Heidelberg, Victoria 3084, Australia.

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http://dx.doi.org/10.1074/jbc.M208440200DOI Listing
December 2002

Metabolism of recombinant progastrin in sheep.

Am J Physiol Endocrinol Metab 2002 Sep;283(3):E449-56

Department of Surgery, University of Melbourne, Austin, and Repatriation Medical Centre, Melbourne, Victoria 3084, Australia.

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http://dx.doi.org/10.1152/ajpendo.00042.2002DOI Listing
September 2002