Graham Rena

Graham Rena

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Graham Rena

Graham Rena

Publications by authors named "Graham Rena"

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Regulation of hepatic glucose production and AMPK by AICAR but not by metformin depends on drug uptake through the equilibrative nucleoside transporter 1 (ENT1).

Diabetes Obes Metab 2018 12 2;20(12):2748-2758. Epub 2018 Aug 2.

Division of Cellular Medicine, Ninewells Hospital and Medical School, University of Dundee, Dundee, UK.

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http://dx.doi.org/10.1111/dom.13455DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6282725PMC
December 2018

Metformin selectively targets redox control of complex I energy transduction.

Redox Biol 2018 04 26;14:187-197. Epub 2017 Aug 26.

Division of Molecular and Clinical Medicine, Ninewells Hospital and Medical School, University of Dundee, Dundee DD1 9SY, Scotland, UK. Electronic address:

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http://dx.doi.org/10.1016/j.redox.2017.08.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5609876PMC
April 2018

Repurposing Metformin for Cardiovascular Disease.

Circulation 2018 Jan;137(5):422-424

Division of Molecular and Clinical Medicine, Ninewells Hospital and Medical School, University of Dundee, Scotland, United Kingdom.

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http://dx.doi.org/10.1161/CIRCULATIONAHA.117.031735DOI Listing
January 2018

The mechanisms of action of metformin.

Diabetologia 2017 09 3;60(9):1577-1585. Epub 2017 Aug 3.

Division of Molecular & Clinical Medicine, School of Medicine, University of Dundee, Dundee, DD1 9SY, UK.

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http://dx.doi.org/10.1007/s00125-017-4342-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5552828PMC
September 2017

New Evidence for the Mechanism of Action of a Type-2 Diabetes Drug Using a Magnetic Bead-Based Automated Biosensing Platform.

ACS Sens 2017 Sep 18;2(9):1329-1336. Epub 2017 Aug 18.

Department of Micro- and Nanotechnology, Technical University of Denmark, DTU Nanotech , Building 345 East, DK-2800 Kongens Lyngby, Denmark.

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http://dx.doi.org/10.1021/acssensors.7b00384DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5613276PMC
September 2017

Investigation of salicylate hepatic responses in comparison with chemical analogues of the drug.

Biochim Biophys Acta 2016 08 27;1862(8):1412-22. Epub 2016 Apr 27.

Cardiovascular and Diabetes Medicine, Ninewells Hospital and Medical School, University of Dundee, Dundee, Scotland DD1 9SY, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/j.bbadis.2016.04.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4894248PMC
August 2016

Anti-Inflammatory Effects of Metformin Irrespective of Diabetes Status.

Circ Res 2016 Aug 14;119(5):652-65. Epub 2016 Jul 14.

From the Division of Molecular and Clinical Medicine, Ninewells Hospital and Medical School (A.R.C., D.L., M.M., C.F., C.B., A.D.M., A.K.F.W., C.C.L., G.R.) and Division of Neuroscience, Ninewells Hospital and Medical School (D.J.K.B.), MRC Protein Phosphorylation and Ubiquitylation Unit, College of Life Sciences (K.S.), University of Dundee, Scotland, United Kingdom; Institute of Biotechnology, University of Helsinki, Finland (V.L.M., T.S., S.C.F.); INSERM U1016, Institut Cochin, CNRS UMR8104, Université Paris Descartes, Sorbonne Paris Cité, France (B.V., M.F.); and Institute of Infection, Immunity, and Inflammation, University of Glasgow, United Kingdom (V.L.M.).

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http://dx.doi.org/10.1161/CIRCRESAHA.116.308445DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4990459PMC
August 2016

The copper binding properties of metformin--QCM-D, XPS and nanobead agglomeration.

Chem Commun (Camb) 2015 Dec;51(97):17313-6

Department of Micro- and Nanotechnology, Technical University of Denmark, DK-2800 Kgs. Lyngby, Denmark.

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http://dx.doi.org/10.1039/c5cc04321bDOI Listing
December 2015

Salicylic acid: old and new implications for the treatment of type 2 diabetes?

Diabetol Int 2014;5(4):212-218. Epub 2014 Jun 12.

Nestlé Institute of Health Sciences SA, EPFL Innovation Park, 1015 Lausanne, Switzerland.

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http://dx.doi.org/10.1007/s13340-014-0177-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5012410PMC
June 2014

Biomolecular mode of action of metformin in relation to its copper binding properties.

Biochemistry 2014 Feb 24;53(4):787-95. Epub 2014 Jan 24.

Institute of Chemical Sciences, School of Engineering and Physical Sciences, Heriot-Watt University , Edinburgh, United Kingdom EH14 4AS.

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http://dx.doi.org/10.1021/bi401444nDOI Listing
February 2014

Molecular mechanism of action of metformin: old or new insights?

Diabetologia 2013 Sep 9;56(9):1898-906. Epub 2013 Jul 9.

Cardiovascular and Diabetes Medicine, Ninewells Hospital and Medical School, University of Dundee, Dundee DD1 9SY, UK.

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http://dx.doi.org/10.1007/s00125-013-2991-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3737434PMC
September 2013

Cellular responses to the metal-binding properties of metformin.

Diabetes 2012 Jun 9;61(6):1423-33. Epub 2012 Apr 9.

Division of Cardiovascular and Diabetes Medicine, Ninewells Hospital and Medical School, University of Dundee, Dundee, Scotland, UK.

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http://dx.doi.org/10.2337/db11-0961DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3357267PMC
June 2012

The anti-neurodegenerative agent clioquinol regulates the transcription factor FOXO1a.

Biochem J 2012 Apr;443(1):57-64

Cardiovascular and Diabetes Medicine, Ninewells Hospital and Medical School, University of Dundee, Dundee DD1 9SY, Scotland, UK.

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http://dx.doi.org/10.1042/BJ20112124DOI Listing
April 2012

Zinc-dependent effects of small molecules on the insulin-sensitive transcription factor FOXO1a and gluconeogenic genes.

Metallomics 2010 Mar 19;2(3):195-203. Epub 2009 Nov 19.

Centre for Neuroscience, Ninewells Hospital and Medical School, University of Dundee, Dundee, Scotland.

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http://dx.doi.org/10.1039/b914984hDOI Listing
March 2010

Black tea polyphenols mimic insulin/insulin-like growth factor-1 signalling to the longevity factor FOXO1a.

Aging Cell 2008 Jan 19;7(1):69-77. Epub 2007 Dec 19.

Neurosciences Institute, Ninewells Hospital and Medical School, University of Dundee, Dundee, Scotland.

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http://dx.doi.org/10.1111/j.1474-9726.2007.00353.xDOI Listing
January 2008

Epigallocatechin gallate (EGCG) mimics insulin action on the transcription factor FOXO1a and elicits cellular responses in the presence and absence of insulin.

Cell Signal 2007 Feb 25;19(2):378-83. Epub 2006 Jul 25.

Neurosciences Institute, Ninewells Hospital and Medical School, University of Dundee, Dundee, Scotland DD1 9SY, UK.

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http://dx.doi.org/10.1016/j.cellsig.2006.07.008DOI Listing
February 2007

D4476, a cell-permeant inhibitor of CK1, suppresses the site-specific phosphorylation and nuclear exclusion of FOXO1a.

EMBO Rep 2004 Jan;5(1):60-5

MRC Protein Phosphorylation Unit, School of Life Sciences, University of Dundee, Dundee DD1 5EH, UK.

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http://dx.doi.org/10.1038/sj.embor.7400048DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1298959PMC
January 2004

Two novel phosphorylation sites on FKHR that are critical for its nuclear exclusion.

EMBO J 2002 May;21(9):2263-71

MRC Protein Phosphorylation Unit, School of Life Sciences, MSI/WTB Complex, University of Dundee, Dow Street, Dundee DD1 5EH, UK.

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http://dx.doi.org/10.1093/emboj/21.9.2263DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC125977PMC
May 2002

Insulin regulation of insulin-like growth factor-binding protein-1 gene expression is dependent on the mammalian target of rapamycin, but independent of ribosomal S6 kinase activity.

J Biol Chem 2002 Mar 9;277(12):9889-95. Epub 2002 Jan 9.

Division of Cellular Signalling, School of Life Sciences, Wellcome Trust Biocentre/Medical Sciences Institute Complex, Dow Street, University of Dundee, Dundee DD1 5EH, United Kingdom.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M109870200
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http://dx.doi.org/10.1074/jbc.M109870200DOI Listing
March 2002