Graham R Williams

Graham R Williams

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PYY is a negative regulator of bone mass and strength.

Bone 2019 Oct 12;127:427-435. Epub 2019 Jul 12.

Molecular Endocrinology Laboratory, Department of Medicine, Hammersmith Campus, Imperial College London, London W12 0NN, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/j.bone.2019.07.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6715792PMC
October 2019

Quantitative X-Ray Imaging of Mouse Bone by Faxitron.

Methods Mol Biol 2019 ;1914:559-569

Molecular Endocrinology Laboratory, Department of Medicine, Imperial College London, Hammersmith Hospital Campus, London, UK.

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http://dx.doi.org/10.1007/978-1-4939-8997-3_30DOI Listing
June 2019

Analysis of Physiological Responses to Thyroid Hormones and Their Receptors in Bone.

Methods Mol Biol 2018 ;1801:123-154

Department of Medicine, Molecular Endocrinology Laboratory, Imperial College London, London, UK.

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http://link.springer.com/10.1007/978-1-4939-7902-8_12
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http://dx.doi.org/10.1007/978-1-4939-7902-8_12DOI Listing
February 2019

Genome-wide association study of extreme high bone mass: Contribution of common genetic variation to extreme BMD phenotypes and potential novel BMD-associated genes.

Bone 2018 09 5;114:62-71. Epub 2018 Jun 5.

Translational Genomics Group, Institute of Health and Biomedical Innovation, Queensland University of Technology at Translational Research Institute, 37 Kent Street, Woolloongabba 4102, QLD, Australia; Royal Brisbane and Women's Hospital, Brisbane, Queensland, Australia.

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https://linkinghub.elsevier.com/retrieve/pii/S87563282183022
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http://dx.doi.org/10.1016/j.bone.2018.06.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6086337PMC
September 2018

Longitudinal Trajectories of Gestational Thyroid Function: A New Approach to Better Understand Changes in Thyroid Function.

J Clin Endocrinol Metab 2018 08;103(8):2889-2900

Molecular Endocrinology Laboratory, Department of Medicine, Imperial College London, Hammersmith Campus, London, United Kingdom.

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http://dx.doi.org/10.1210/jc.2017-02556DOI Listing
August 2018

Thyroid Stimulating Hormone and Bone Mineral Density: Evidence From a Two-Sample Mendelian Randomization Study and a Candidate Gene Association Study.

J Bone Miner Res 2018 07 18;33(7):1318-1325. Epub 2018 Apr 18.

Department of Internal Medicine, Section of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, the Netherlands.

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http://dx.doi.org/10.1002/jbmr.3426DOI Listing
July 2018

13th International Workshop on Resistance to Thyroid Hormone and Thyroid Hormone Action.

Thyroid 2018 06 2;28(6):690-691. Epub 2018 May 2.

3 Departments of Medicine and Pediatrics and Committee on Genetics, The University of Chicago , Chicago, Illinois.

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http://dx.doi.org/10.1089/thy.2018.0173DOI Listing
June 2018

Common signalling pathways in macrophage and osteoclast multinucleation.

J Cell Sci 2018 06 5;131(11). Epub 2018 Jun 5.

Centre for Inflammatory Disease, Imperial College London, London W12 0NN, UK

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http://dx.doi.org/10.1242/jcs.216267DOI Listing
June 2018

Life-Course Genome-wide Association Study Meta-analysis of Total Body BMD and Assessment of Age-Specific Effects.

Am J Hum Genet 2018 01;102(1):88-102

Department of Internal Medicine, Erasmus MC, 3000 CA Rotterdam, the Netherlands; The Generation R Study Group, Erasmus MC, 3000 CA Rotterdam, the Netherlands; Department of Epidemiology, Erasmus MC, 3000 CA Rotterdam, the Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.ajhg.2017.12.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5777980PMC
January 2018

An Essential Physiological Role for MCT8 in Bone in Male Mice.

Endocrinology 2017 09;158(9):3055-3066

Molecular Endocrinology Laboratory, Department of Medicine, Hammersmith Campus, Imperial College London, London W12 0NN, United Kingdom.

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http://dx.doi.org/10.1210/en.2017-00399DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5659673PMC
September 2017

A Novel Method for Gene-Specific Enhancement of Protein Translation by Targeting 5'UTRs of Selected Tumor Suppressors.

PLoS One 2016 12;11(5):e0155359. Epub 2016 May 12.

The Centre of Postgraduate Medical Education, Department of Biochemistry and Molecular Biology, ul. Marymoncka 99/103, 01-813, Warsaw, Poland.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0155359PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4865139PMC
July 2017

Rapid phenotyping of knockout mice to identify genetic determinants of bone strength.

J Endocrinol 2016 10 17;231(1):R31-46. Epub 2016 Aug 17.

Molecular Endocrinology LaboratoryDepartment of Medicine, Imperial College London, London, UK

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http://dx.doi.org/10.1530/JOE-16-0258DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5064764PMC
October 2016

Pediatric Differentiated Thyroid Carcinoma in The Netherlands: A Nationwide Follow-Up Study.

J Clin Endocrinol Metab 2016 05 10;101(5):2031-9. Epub 2016 Mar 10.

Departments of Endocrinology (M.S.K.H., M.N., T.P.L.), Nuclear Medicine and Molecular Imaging (A.H.B.), Epidemiology (J.G.M.B.), and Surgical Oncology (J.T.M.P.), University of Groningen, University Medical Center Groningen, and Departments of Pediatric Endocrinology (G.B.) and Pediatric Oncology (W.J.E.T.), Beatrix Children's Hospital, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, The Netherlands; Department of Internal Medicine (E.W.C.M.v.D.), VU University Medical Center, 1007 MB Amsterdam, The Netherlands; Department of Internal Medicine (B.H.), Division of Endocrinology, Maastricht University Medical Center, 6202 AZ Maastricht, The Netherlands; Department of Pediatric Oncology (M.M.v.d.H.-E.), Sophia Children's Hospital, Erasmus Medical Center, 3000 CB Rotterdam, The Netherlands; Department of Internal Medicine (E.P.M.C.), Division of Endocrinology, Leiden University Medical Center, 2300 RC Leiden, The Netherlands; Department of Pediatric Oncology (L.C.M.K., H.J.H.v.d.P., C.M.R.), Emma Children's Hospital, Academic Medical Center, 1100 DD Amsterdam, The Netherlands; Department of Internal Medicine (R.T.N.-M., J.W.A.S.), Division of Endocrinology, Radboud University Medical Center, 6500 HB Nijmegen, The Netherlands; Department of Medical Oncology (H.J.H.v.d.P.), Academic Medical Center, 1100 DD Amsterdam, The Netherlands; Department of Internal Medicine (R.P.P.) and Rotterdam Thyroid Center (R.P.P.), Erasmus Medical Center, 3000 CA Rotterdam, The Netherlands; Institute of Pathology (K.W.S.), University Hospital Essen, University of Duisburg-Essen, 45147 Essen, Germany; Department of Medicine (G.R.W.), Imperial College London, London SW7 2AZ, United Kingdom; and Department of Pediatrics (H.M.v.S.), Wilhelmina Children's Hospital, University Medical Center Utrecht, 3508 GA Utrecht, The Netherlands.

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http://dx.doi.org/10.1210/jc.2015-3290DOI Listing
May 2016

Role of Thyroid Hormones in Skeletal Development and Bone Maintenance.

Endocr Rev 2016 Apr 10;37(2):135-87. Epub 2016 Feb 10.

Molecular Endocrinology Laboratory, Department of Medicine, Imperial College London, Hammersmith Campus, London W12 0NN, United Kingdom.

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http://dx.doi.org/10.1210/er.2015-1106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4823381PMC
April 2016

Paradoxical Relationship Between Body Mass Index and Thyroid Hormone Levels: A Study Using Mendelian Randomization.

J Clin Endocrinol Metab 2016 Feb 23;101(2):730-8. Epub 2015 Nov 23.

Thyroid Research Group (P.N.T., O.O., J.W.G., C.M.D.) and Institute of Molecular and Experimental Medicine (A.R.), Cardiff University School of Medicine, Cardiff, CF14 4XN United Kingdom; Medical Research Council Integrative Epidemiology Unit (R.R., N.D., G.D.S., N.J.T.), University of Bristol, Bristol, BS8 2BN United Kingdom; Department of Social and Community Medicine (A.S., A.G., K.N., S.R.), University of Bristol, Bristol, BS8 2BN United Kingdom; Department of Biochemistry (K.S.), Bristol Royal Infirmary University Hospitals Bristol National Health Service Foundation Trust, Bristol, BS2 8HW United Kingdom; Geschäftsleiter Medizinisches Versorgungszentrum Labor Dr. Reising-Ackermann und Kollegen (W.W.), D-04289 Leipzig, Germany; Department of Biochemistry (A.T.), Royal United Hospital, Bath, BA1 3NG United Kingdom; Department of Non-Communicable Disease Epidemiology (D.N.), Faculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, CF14 4XN United Kingdom; Molecular Endocrinology Group (G.R.W.), Department of Medicine, Imperial College London, London, WC1E 7HT United Kingdom; and Musculoskeletal Research Unit (J.H.T.), University of Bristol, Learning and Research Southmead Hospital, Westbury on Trym, Bristol, BS10 5NB United Kingdom.

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http://dx.doi.org/10.1210/jc.2015-3505DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4880123PMC
February 2016

Thyrostimulin Regulates Osteoblastic Bone Formation During Early Skeletal Development.

Endocrinology 2015 09 27;156(9):3098-113. Epub 2015 May 27.

Molecular Endocrinology Laboratory (J.H.D.B., J.G.L., A.G., J.B.C., E.M., G.R.W.), Department of Medicine, Imperial College London, London, W12 0NN United Kingdom; Department of Endocrinology (A.v.d.S., C.v.Z., A.Boe.), Academic Medical Centre, University of Amsterdam, 1100 DD Amsterdam, The Netherlands; Bone Biology Program (J.D., P.I.C.), Garvan Institute of Medical Research, Sydney, NSW 2010 Australia; and Centre for Oral Growth and Development (A.Boy.), Queen Mary, University of London, London, E1 4NS United Kingdom.

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http://dx.doi.org/10.1210/en.2014-1943DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4541616PMC
September 2015

Adult mice lacking the type 2 iodothyronine deiodinase have increased subchondral bone but normal articular cartilage.

Thyroid 2015 Mar 3;25(3):269-77. Epub 2015 Feb 3.

Molecular Endocrinology Group, Department of Medicine, Imperial College London , London, United Kingdom .

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http://dx.doi.org/10.1089/thy.2014.0476DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4361410PMC
March 2015

Thyroid hormone receptor α mutation causes a severe and thyroxine-resistant skeletal dysplasia in female mice.

Endocrinology 2014 Sep 10;155(9):3699-712. Epub 2014 Jun 10.

Department of Medicine (J.H.D.B., G.R.W.), Imperial College London, London W12 0NN, United Kingdom; Dental Physical Sciences, Oral Growth and Development (A.B.), Queen Mary University of London, London E1 4NS, United Kingdom; Laboratory of X-Ray Micro-Computed Tomography and Nano-Computed Tomography (T.Z.), Central European Institute of Technology, Brno University of Technology CZ-61600 Brno, Czech Republic; Sheffield Myeloma Research Team (H.E.), University of Sheffield, Sheffield S10 2RX, United Kingdom; Bone Biology Program (P.I.C.), Garvan Institute of Medical Research, Sydney NSW 2010, Australia; and Laboratory of Molecular Biology (X.Z., J.W.P., S-y.C.), National Cancer Institute, Bethesda, Maryland 20892.

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http://dx.doi.org/10.1210/en.2013-2156DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4138578PMC
September 2014

Thyrostimulin deficiency does not alter peripheral responses to acute inflammation-induced nonthyroidal illness.

Am J Physiol Endocrinol Metab 2014 Sep 12;307(6):E527-37. Epub 2014 Aug 12.

Department of Endocrinology, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands; and

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http://dx.doi.org/10.1152/ajpendo.00266.2014DOI Listing
September 2014

Is prophylactic anti-resorptive therapy required in thyroid cancer patients receiving TSH-suppressive treatment with thyroxine?

J Endocrinol Invest 2014 Aug 18;37(8):775-779. Epub 2014 Jun 18.

Molecular Endocrinology Group, Department of Medicine, Imperial College London, Hammersmith Campus, Du Cane Road, London, W12 0NN, UK.

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http://dx.doi.org/10.1007/s40618-014-0110-9DOI Listing
August 2014

Role of thyroid hormone receptor-α1 in endochondral ossification.

Endocrinology 2014 Aug;155(8):2747-50

Molecular Endocrinology Group, Department of Medicine, Imperial College London, London W12 0NN, United Kingdom.

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http://dx.doi.org/10.1210/en.2014-1527DOI Listing
August 2014

THRA and DIO2 mutations are unlikely to be a common cause of increased bone mineral density in euthyroid post-menopausal women.

Eur J Endocrinol 2014 Apr 13;170(4):637-44. Epub 2014 Mar 13.

Molecular Endocrinology Group, Department of Medicine, Imperial College London, 10th Floor Commonwealth Building, Hammersmith Campus, Du Cane Road, London W12 0NN, UK.

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http://dx.doi.org/10.1530/EJE-13-1009DOI Listing
April 2014

Classification and proposed nomenclature for inherited defects of thyroid hormone action, cell transport, and metabolism.

J Clin Endocrinol Metab 2014 Mar;99(3):768-70

Departments of Medicine (S.R., A.M.D., R.E.W.), Pediatrics (S.R., R.E.W.), and Genetics (S.R.), The University of Chicago, Chicago, Illinois 60637; Department of Medicine (J.H.D.B., G.R.W.), Imperial College London, Hammersmith Campus, London W12 0NN, United Kingdom; Department of Clinical Sciences and Community Health (P.B.-P., L.P.), University of Milan, Fondazione Ca' Granda Policlinico (P.B.-P.), and Istituto Auxologico Italiano (L.P.), 20133 Milan, Italy; Instituto de Investigaciones Biomédicas (J.B.), Consejo Superior de Investigaciones Científicas-Universidad Autonoma de Madrid and Centro de Investigación Biomédica en Red de Enfermedades Raras, 28029 Madrid, Spain; Department of Medicine (G.B.), David Geffen School of Medicine, University of California at Los Angeles, California 90095; Wellcome-Medical Research Council Institute of Metabolic Science (K.C.), University of Cambridge, Cambridge CB2 0QQ, United Kingdom; Thyroidmanager and Endotext (L.J.D.G.), South Dartmouth, Massachusetts 02748; Raymond and Ruth Perelman School of Medicine (J.L.J.), University of Pennsylvania, Philadelphia, Pennsylvania 19104; Division of Endocrinology, Metabolism, and Molecular Medicine and Center for Genetic Medicine (P.A.K.), Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611; Research Institute of Environmental Medicine (Y.M.), Nagoya University, Nagoya 466-8550, Japan; Ecole Normale Supérieure de Lyon (J.S.), 69342 Lyon, France; and Laboratory of Hormone Action, Singapore Institute of Clinical Sciences (P.M.Y.), Singapore 138669.

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https://academic.oup.com/jcem/article-lookup/doi/10.1210/jc.
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http://dx.doi.org/10.1210/jc.2013-3393DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3942236PMC
March 2014

Mechanisms of action of thyroid hormones in the skeleton.

Biochim Biophys Acta 2013 Jul 25;1830(7):3979-86. Epub 2012 May 25.

The Medical Centre of Postgraduate Education, Department of Biochemistry and Molecular Biology, ul.Marymoncka 99/103, 01-813 Warsaw, Poland.

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http://dx.doi.org/10.1016/j.bbagen.2012.05.005DOI Listing
July 2013

Thyroid hormone actions in cartilage and bone.

Eur Thyroid J 2013 Mar 19;2(1):3-13. Epub 2012 Dec 19.

Molecular Endocrinology Group, Department of Medicine, Imperial College London, London, UK.

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http://dx.doi.org/10.1159/000345548DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3821494PMC
March 2013

Bone Mineral Content and Density.

Curr Protoc Mouse Biol 2012 Dec 1;2(4):365-400. Epub 2012 Dec 1.

Academic Endocrine Unit, Nuffield Department of Clinical Medicine, University of Oxford, Oxford Centre for Diabetes, Endocrinology and Metabolism, Churchill Hospital, Headington, Oxford, United Kingdom.

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http://dx.doi.org/10.1002/9780470942390.mo120124DOI Listing
December 2012

Bone turnover and bone mineral density are independently related to selenium status in healthy euthyroid postmenopausal women.

J Clin Endocrinol Metab 2012 Nov 17;97(11):4061-70. Epub 2012 Aug 17.

Molecular Endocrinology Group, Imperial College London, 7N2a Commonwealth Building, Hammersmith Campus, Du Cane Road, London W12 0NN, United Kingdom.

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http://dx.doi.org/10.1210/jc.2012-2121DOI Listing
November 2012

Mice lacking the calcineurin inhibitor Rcan2 have an isolated defect of osteoblast function.

Endocrinology 2012 Jul 16;153(7):3537-48. Epub 2012 May 16.

Molecular Endocrinology Group, Department of Medicine, Imperial College London, Hammersmith Campus, London W12 0NN, United Kingdom.

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http://dx.doi.org/10.1210/en.2011-1814DOI Listing
July 2012

The skeletal consequences of thyrotoxicosis.

J Endocrinol 2012 Jun 27;213(3):209-21. Epub 2012 Mar 27.

Molecular Endocrinology Group, Department of Medicine, Imperial College London, Hammersmith Campus, Room 7N2b, Commonwealth Building, Du Cane Road, London W12 0NN, UK.

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http://dx.doi.org/10.1530/JOE-12-0059DOI Listing
June 2012

Thyroid hormone metabolism in skeletal development and adult bone maintenance.

Trends Endocrinol Metab 2012 Apr 12;23(4):155-62. Epub 2011 Dec 12.

Molecular Endocrinology Group, Department of Medicine, Imperial College London, Hammersmith Campus, Du Cane Road, London W12 0NN, UK.

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https://linkinghub.elsevier.com/retrieve/pii/S10432760110017
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http://dx.doi.org/10.1016/j.tem.2011.11.002DOI Listing
April 2012

Quantitative X-ray imaging of rodent bone by Faxitron.

Methods Mol Biol 2012 ;816:499-506

Molecular Endocrinology Group, Department of Medicine and MRC Clinical Sciences Centre, Imperial College London, Hammersmith Campus, London, UK.

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http://dx.doi.org/10.1007/978-1-61779-415-5_29DOI Listing
March 2012

A mouse model for spondyloepiphyseal dysplasia congenita with secondary osteoarthritis due to a Col2a1 mutation.

J Bone Miner Res 2012 Feb;27(2):413-28

Academic Endocrine Unit, Nuffield Department of Clinical Medicine, Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Churchill Hospital, Headington, Oxford, United Kingdom.

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http://dx.doi.org/10.1002/jbmr.547DOI Listing
February 2012

Deiodinases: the balance of thyroid hormone: local control of thyroid hormone action: role of type 2 deiodinase.

J Endocrinol 2011 Jun 3;209(3):261-72. Epub 2011 Feb 3.

Molecular Endocrinology Group, Department of Medicine and Medical Research Council Clinical Sciences Centre, Imperial College London, Hammersmith Hospital, London W12 0NN, UK.

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http://dx.doi.org/10.1530/JOE-10-0448DOI Listing
June 2011

Activated invariant NKT cells regulate osteoclast development and function.

J Immunol 2011 Mar 28;186(5):2910-7. Epub 2011 Jan 28.

Center for Hematology, Hammersmith Hospital, Imperial College London, London W12 0NN, United Kingdom.

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http://dx.doi.org/10.4049/jimmunol.1002353DOI Listing
March 2011

Thyroid and bone.

Arch Biochem Biophys 2010 Nov 23;503(1):129-36. Epub 2010 Jun 23.

Molecular Endocrinology Group, Department of Medicine and MRC Clinical Sciences Centre, Imperial College London, London W12 0NN, UK.

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http://dx.doi.org/10.1016/j.abb.2010.06.021DOI Listing
November 2010

Untranslated regions of thyroid hormone receptor beta 1 mRNA are impaired in human clear cell renal cell carcinoma.

Biochim Biophys Acta 2010 Nov 3;1802(11):995-1005. Epub 2010 Aug 3.

Department of Biochemistry and Molecular Biology, The Medical Centre of Postgraduate Education, Warsaw, Poland.

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http://dx.doi.org/10.1016/j.bbadis.2010.07.025DOI Listing
November 2010

Thyroid function within the upper normal range is associated with reduced bone mineral density and an increased risk of nonvertebral fractures in healthy euthyroid postmenopausal women.

J Clin Endocrinol Metab 2010 Jul 21;95(7):3173-81. Epub 2010 Apr 21.

Molecular Endocrinology Group, 7th Floor Commonwealth Building, Hammersmith Hospital, Du Cane Road, London W12 0NN, United Kingdom.

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https://academic.oup.com/jcem/article-lookup/doi/10.1210/jc.
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http://dx.doi.org/10.1210/jc.2009-2630DOI Listing
July 2010

Optimal bone strength and mineralization requires the type 2 iodothyronine deiodinase in osteoblasts.

Proc Natl Acad Sci U S A 2010 Apr 5;107(16):7604-9. Epub 2010 Apr 5.

Division of Medicine and Medical Research Council Clinical Sciences Centre, Imperial College London, Hammersmith Hospital, London W12 0NN, United Kingdom.

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http://dx.doi.org/10.1073/pnas.0911346107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2867713PMC
April 2010

Actions of thyroid hormones in bone.

Endokrynol Pol 2009 Sep-Oct;60(5):380-8

Department of Medicine & MRC Clinical Sciences Centre, Imperial College London, UK.

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February 2010

Bone signaling pathways and treatment of osteoporosis.

Expert Rev Endocrinol Metab 2009 Nov;4(6):639-650

d Molecular Endocrinology Group, Imperial College London, MRC Clinical Sciences Centre, Room 7N2a, 7th Floor Commonwealth Building, Hammersmith Hospital, Du Cane Road, London, W12 0NN, UK.

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http://dx.doi.org/10.1586/eem.09.38DOI Listing
November 2009

The skeletal phenotypes of TRalpha and TRbeta mutant mice.

J Mol Endocrinol 2009 Apr 29;42(4):269-82. Epub 2008 Dec 29.

Molecular Endocrinology Group, Division of Medicine, Imperial College London, MRC Clinical Sciences Centre, Hammersmith Hospital, London, UK.

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https://jme.bioscientifica.com/view/journals/jme/42/4/269.xm
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http://dx.doi.org/10.1677/JME-08-0142DOI Listing
April 2009

Does serum TSH level have thyroid hormone independent effects on bone turnover?

Nat Clin Pract Endocrinol Metab 2009 Jan 28;5(1):10-1. Epub 2008 Oct 28.

Division of Medicine, Medical Research Council Clinical Sciences Centre, Imperial College London, UK.

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http://dx.doi.org/10.1038/ncpendmet1004DOI Listing
January 2009

Critical role of the hypothalamic-pituitary-thyroid axis in bone.

Bone 2008 Sep 16;43(3):418-26. Epub 2008 May 16.

Molecular Endocrinology Group, Division of Medicine and MRC Clinical Sciences Centre, Imperial College London, Hammersmith Hospital, London, W12 0NN, UK.

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http://dx.doi.org/10.1016/j.bone.2008.05.007DOI Listing
September 2008

Iodothyronine deiodinase enzyme activities in bone.

Bone 2008 Jul 4;43(1):126-134. Epub 2008 Apr 4.

Molecular Endocrinology Group, Division of Medicine and Medical Research Council (MRC) Clinical Sciences Centre, Imperial College London, Hammersmith Hospital, London W12 0NN, UK. Electronic address:

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http://dx.doi.org/10.1016/j.bone.2008.03.019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2681075PMC
July 2008

Radioiodine treatment for benign thyroid disorders: results of a nationwide survey of UK endocrinologists.

Clin Endocrinol (Oxf) 2008 May 31;68(5):814-20. Epub 2007 Oct 31.

Department of Endocrinology, Royal Devon and Exeter Hospital, Exeter, UK.

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http://dx.doi.org/10.1111/j.1365-2265.2007.03097.xDOI Listing
May 2008

Regulation of fibroblast growth factor receptor-1 (FGFR1) by thyroid hormone: identification of a thyroid hormone response element in the murine Fgfr1 promoter.

Endocrinology 2007 Dec 30;148(12):5966-76. Epub 2007 Aug 30.

Gene Regulation Section, Laboratory of Molecular Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892-4264, USA.

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http://dx.doi.org/10.1210/en.2007-0114DOI Listing
December 2007

Complex interactions between thyroid hormone and fibroblast growth factor signalling.

Curr Opin Endocrinol Diabetes Obes 2007 Oct;14(5):410-5

Molecular Endocrinology Group, Division of Medicine & MRC Clinical Sciences Centre, Imperial College London, Hammersmith Hospital, London, UK.

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http://dx.doi.org/10.1097/MED.0b013e3282eee92cDOI Listing
October 2007

Thyroid status during skeletal development determines adult bone structure and mineralization.

Mol Endocrinol 2007 Aug 8;21(8):1893-904. Epub 2007 May 8.

Molecular Endocrinology Group, MRC Clinical Sciences Center, Hammersmith Hospital, London W12 0NN, United Kingdom.

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http://dx.doi.org/10.1210/me.2007-0157DOI Listing
August 2007

Characterization of skeletal phenotypes of TRalpha1 and TRbeta mutant mice: implications for tissue thyroid status and T3 target gene expression.

Nucl Recept Signal 2006 7;4:e011. Epub 2006 Jul 7.

Molecular Endocrinology Group, Division of Medicine and MRC Clinical Sciences Centre, Imperial College London, Hammersmith Campus, London, UK.

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http://dx.doi.org/10.1621/nrs.04011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1513065PMC
June 2007

Hypogonadal bone loss: sex steroids or gonadotropins?

Endocrinology 2007 Jun;148(6):2610-2

Molecular Endocrinology Group, Medical Research Council Clinical Sciences Centre, Hammersmith Hospital, Du Cane Road, London W12 0NN, United Kingdom.

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http://dx.doi.org/10.1210/en.2007-0337DOI Listing
June 2007

Thyroid hormone excess rather than thyrotropin deficiency induces osteoporosis in hyperthyroidism.

Mol Endocrinol 2007 May 27;21(5):1095-107. Epub 2007 Feb 27.

Molecular Endocrinology Group, Division of Medicine and Medical Research Council (MRC) Clinical Sciences Centre, Imperial College London, Hammersmith Hospital, London W12 0NN, United Kingdom.

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http://dx.doi.org/10.1210/me.2007-0033DOI Listing
May 2007

The rat thyroid hormone receptor (TR) Deltabeta3 displays cell-, TR isoform-, and thyroid hormone response element-specific actions.

Endocrinology 2007 Apr 11;148(4):1764-73. Epub 2007 Jan 11.

Molecular Endocrinology Group, Division of Medicine and Medical Research Council Clinical Sciences Centre, Imperial College London, Clinical Research Building 5th Floor, Hammersmith Hospital, Du Cane Road, London W12 0NN, United Kingdom.

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http://dx.doi.org/10.1210/en.2006-1248DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2681178PMC
April 2007

Thyroid hormone-stimulated differentiation of primary rib chondrocytes in vitro requires thyroid hormone receptor beta.

J Endocrinol 2006 Oct;191(1):221-8

INSERM U577-Biomatériaux et Réparation Tissulaire, Université Bordeaux 2 Victor Segalen, Zone Nord, Bâtiment 4A, 2ème étage, 33076 Bordeaux Cedex, France.

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http://dx.doi.org/10.1677/joe.1.06838DOI Listing
October 2006

Disorders of calcium metabolism.

Practitioner 2006 Sep;250(1686):4-6, 8

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September 2006

Unexpected shortness of breath in a patient with Cushing's syndrome.

Lancet 2006 Feb;367(9508):446

Endocrine Unit, Imperial College Faculty of Medicine, Hammersmith Hospital, London W12 ONN, UK.

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http://dx.doi.org/10.1016/S0140-6736(06)68146-4DOI Listing
February 2006

Contrasting skeletal phenotypes in mice with an identical mutation targeted to thyroid hormone receptor alpha1 or beta.

Mol Endocrinol 2005 Dec 28;19(12):3045-59. Epub 2005 Jul 28.

Molecular Endocrinology Group, 5th Floor Clinical Research Building, Medical Research Council Clinical Sciences Centre, Hammersmith Hospital, Du Cane Road, London W12 0NN, United Kingdom.

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http://dx.doi.org/10.1210/me.2005-0224DOI Listing
December 2005

Thyroid hormones regulate fibroblast growth factor receptor signaling during chondrogenesis.

Endocrinology 2005 Dec 8;146(12):5568-80. Epub 2005 Sep 8.

Molecular Endocrinology Group, Division of Medicine and Medical Research Council Clinical Sciences Centre, Imperial College London, UK.

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http://dx.doi.org/10.1210/en.2005-0762DOI Listing
December 2005

The thyroid hormone receptor beta-specific agonist GC-1 selectively affects the bone development of hypothyroid rats.

J Bone Miner Res 2005 Feb 22;20(2):294-304. Epub 2004 Nov 22.

Department of Anatomy, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo, SP, Brazil.

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http://doi.wiley.com/10.1359/JBMR.041116
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http://dx.doi.org/10.1359/JBMR.041116DOI Listing
February 2005

Severe hypercalcaemia from secretion of parathyroid hormone-related peptide.

Lancet Oncol 2004 Oct;5(10):633-5

Department of Metabolic Medicine, Division of Investigative Sciences, Imperial College of Science Technology and Medicine, Hammersmith Campus, London, UK.

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https://linkinghub.elsevier.com/retrieve/pii/S14702045040159
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http://dx.doi.org/10.1016/S1470-2045(04)01599-2DOI Listing
October 2004

The thyroid and the skeleton.

Clin Endocrinol (Oxf) 2004 Sep;61(3):285-98

Molecular Endocrinology Group, 5th Floor MRC Clinical Sciences Centre, Faculty of Medicine, Imperial College London, London, UK.

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http://dx.doi.org/10.1111/j.1365-2265.2004.02053.xDOI Listing
September 2004

Multiple messenger ribonucleic acid variants regulate cell-specific expression of human thyroid hormone receptor beta1.

Mol Endocrinol 2004 Jul 22;18(7):1631-42. Epub 2004 Apr 22.

Molecular Endocrinology Group, Division of Medicine and Medical Research Council Clinical Sciences Centre, Faculty of Medicine, Imperial College London, London W12 0NN, United Kingdom.

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http://dx.doi.org/10.1210/me.2003-0346DOI Listing
July 2004

Renal magnesium loss causing hypomagnesaemia and autonomous hyperparathyroidism.

Nephrol Dial Transplant 2004 Apr;19(4):977-80

Molecular Endocrinology Group, MRC Clinical Sciences Centre, 5th Floor, Clinical Research Building, Hammersmith Hospital, Du Cane Road, London W12 0NN, UK.

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https://academic.oup.com/ndt/article-lookup/doi/10.1093/ndt/
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http://dx.doi.org/10.1093/ndt/gfh029DOI Listing
April 2004

Mechanisms of thyroid hormone receptor-specific nuclear and extra nuclear actions.

Mol Cell Endocrinol 2003 Dec;213(1):1-11

Molecular Endocrinology Group, Division of Medicine and MRC Clinical Sciences Centre, Faculty of Medicine, Imperial College London, Hammersmith Hospital, Du Cane Road, London W12 0NN, UK.

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http://linkinghub.elsevier.com/retrieve/pii/S030372070300413
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http://dx.doi.org/10.1016/j.mce.2003.10.033DOI Listing
December 2003

The molecular actions of thyroid hormone in bone.

Trends Endocrinol Metab 2003 Oct;14(8):356-64

Molecular Endocrinology Group, Division of Medicine and MRC Clinical Sciences Centre, Faculty of Medicine, Imperial College London, Hammersmith Hospital, Du Cane Road, London, W12 0NN, UK.

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http://dx.doi.org/10.1016/s1043-2760(03)00144-9DOI Listing
October 2003

Thyroid hormone activates fibroblast growth factor receptor-1 in bone.

Mol Endocrinol 2003 Sep 12;17(9):1751-66. Epub 2003 Jun 12.

Molecular Endocrinology Group, Medical Research Council Clinical Sciences Centre, Clinical Research Building, 5th Floor, Hammersmith Hospital, Du Cane Road, London W12 0NN, United Kingdom.

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http://dx.doi.org/10.1210/me.2003-0137DOI Listing
September 2003

A thyrotoxic skeletal phenotype of advanced bone formation in mice with resistance to thyroid hormone.

Mol Endocrinol 2003 Jul 3;17(7):1410-24. Epub 2003 Apr 3.

Molecular Endocrinology Group, Division of Medicine and Medical Research Council Clinical Sciences Centre, Faculty of Medicine, Imperial College London, Hammersmith Hospital, United Kingdom.

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http://dx.doi.org/10.1210/me.2002-0296DOI Listing
July 2003

Interactions between GH, IGF-I, glucocorticoids, and thyroid hormones during skeletal growth.

Pediatr Res 2002 Aug;52(2):137-47

Department of Clinical Research, Christie Hospital National Health Service Trust, Manchester, UK.

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http://dx.doi.org/10.1203/00006450-200208000-00003DOI Listing
August 2002

Thyroid hormone gene targets in ROS 17/2.8 osteoblast-like cells identified by differential display analysis.

Thyroid 2002 Aug;12(8):663-71

Molecular Endocrinology Laboratory, VA Greater Los Angeles Healthcare System, Department of Medicine, UCLA School of Medicine, Los Angeles, California 90073, USA.

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http://dx.doi.org/10.1089/105072502760258631DOI Listing
August 2002

Mechanism of thyroid hormone action.

Thyroid 2002 Jun;12(6):441-6

Molecular Endocrinology Group, Division of Medicine & MRC Clinical Sciences Centre, Faculty of Medicine, Imperial College of Science Technology and Medicine, Hammersmith Hospital, London, United Kingdom.

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http://dx.doi.org/10.1089/105072502760143791DOI Listing
June 2002

TR expression and function in human bone marrow stromal and osteoblast-like cells.

J Clin Endocrinol Metab 2002 Feb;87(2):906-14

Department of Endocrinology, St. Bartholomew's and the Royal London School of Medicine and Dentistry, West Smithfield, London, United Kingdom EC1A 7BE.

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http://dx.doi.org/10.1210/jcem.87.2.8226DOI Listing
February 2002

Molecular mechanisms of thyroid hormone effects on bone growth and function.

Mol Genet Metab 2002 Jan;75(1):17-30

Division of Medicine & MRC Clinical Sciences Centre, Hammersmith Hospital, Du Cane Road, London, W12 0NN, United Kingdom.

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http://dx.doi.org/10.1006/mgme.2001.3268DOI Listing
January 2002