Graham E Searle

Graham E Searle

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Graham E Searle

Graham E Searle

Publications by authors named "Graham E Searle"

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Imaging Aβ and tau in early stage Alzheimer's disease with [F]AV45 and [F]AV1451.

EJNMMI Res 2018 Mar 2;8(1):19. Epub 2018 Mar 2.

Imanova Ltd., Burlington Danes Building, Imperial College London, Hammersmith Hospital, Du Cane Road, London, W12 0NN, UK.

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http://dx.doi.org/10.1186/s13550-018-0371-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5834417PMC
March 2018

Loss of phosphodiesterase 4 in Parkinson disease: Relevance to cognitive deficits.

Neurology 2017 Aug 12;89(6):586-593. Epub 2017 Jul 12.

From the Neurodegeneration Imaging Group (F.N., H.W., G.P., M.P.) and Department of Neuroimaging (M.A.M., E.A.R.), Institute of Psychiatry, Psychology and Neuroscience (IoPPN), King's College London; Imanova Ltd., Centre for Imaging Sciences (C.C., G.E.S., R.N.G., E.A.R.), and Division of Brain Sciences, Imperial College London (R.N.G), Hammersmith Hospital; and Sobell Department of Motor Neuroscience (T.F.), UCL Institute of Neurology, London, UK.

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http://dx.doi.org/10.1212/WNL.0000000000004201DOI Listing
August 2017

Phosphodiesterase 10A in Schizophrenia: A PET Study Using [(11)C]IMA107.

Am J Psychiatry 2016 07 19;173(7):714-21. Epub 2016 Feb 19.

From the Department of Psychosis Studies, the Neurodegeneration Imaging Group, the Department of Basic and Clinical Neuroscience, and the Department of Neuroimaging, Institute of Psychiatry, Psychology, and Neuroscience, King's College London, London; the Division of Brain Sciences, Department of Medicine, and the Psychiatric Imaging Group, Medical Research Council Clinical Sciences Centre, Institute of Clinical Science, Imperial College London, London; and Imanova Ltd., Centre for Imaging Sciences, Hammersmith Hospital, London.

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http://dx.doi.org/10.1176/appi.ajp.2015.15040518DOI Listing
July 2016

Impact of image-based motion correction on dopamine D3/D2 receptor occupancy-comparison of groupwise and frame-by-frame registration approaches.

EJNMMI Phys 2015 Dec 29;2(1):15. Epub 2015 Jul 29.

Department of Engineering Science, Institute of Biomedical Engineering, University of Oxford, Oxford, UK.

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http://dx.doi.org/10.1186/s40658-015-0117-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4538721PMC
December 2015

Quantitative imaging of protein targets in the human brain with PET.

Phys Med Biol 2015 Nov 29;60(22):R363-411. Epub 2015 Oct 29.

Division of Brain Sciences, Department of Medicine, Imperial College London, UK. Imanova Limited, Hammersmith Hospital, London, UK. Institute of Biomedical Engineering, Department of Engineering Science, University of Oxford, UK.

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http://dx.doi.org/10.1088/0031-9155/60/22/R363DOI Listing
November 2015

Altered PDE10A expression detectable early before symptomatic onset in Huntington's disease.

Brain 2015 Oct 21;138(Pt 10):3016-29. Epub 2015 Jul 21.

1 Neurodegeneration Imaging Group, Department of Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK 2 Division of Brain Sciences, Department of Medicine, Imperial College London, London, UK

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http://dx.doi.org/10.1093/brain/awv214DOI Listing
October 2015

Loss of phosphodiesterase 10A expression is associated with progression and severity in Parkinson's disease.

Brain 2015 Oct 25;138(Pt 10):3003-15. Epub 2015 Jul 25.

1 Neurodegeneration Imaging Group, Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK 2 Division of Brain Sciences, Department of Medicine, Imperial College London, London, UK

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http://dx.doi.org/10.1093/brain/awv219DOI Listing
October 2015

The simplified reference tissue model: model assumption violations and their impact on binding potential.

J Cereb Blood Flow Metab 2015 Feb 26;35(2):304-11. Epub 2014 Nov 26.

1] Imanova, Centre for Imaging Sciences, Imperial College London, Hammersmith Hospital, London, UK [2] Division of Brain Sciences, Department of Medicine, Imperial College London, London, UK [3] Department of Engineering Science, University of Oxford, Oxford, UK.

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http://dx.doi.org/10.1038/jcbfm.2014.202DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4426748PMC
February 2015

Advances in biomathematical modeling for PET neuroreceptor imaging.

Drug Discov Today Technol 2011 ;8(2-4):e45-51

Imanova Limited, Burlington Danes Building, Imperial College London, Hammersmith Hospital, London, Du Cane Road, W12 0NN, UK.

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http://dx.doi.org/10.1016/j.ddtec.2012.01.001DOI Listing
July 2014

In vivo imaging of cerebral dopamine D3 receptors in alcoholism.

Neuropsychopharmacology 2014 Jun 28;39(7):1703-12. Epub 2014 Jan 28.

Centre for Neuropsychopharmacology, Division of Brain Sciences, Faculty of Medicine, Imperial College London, London, UK.

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http://dx.doi.org/10.1038/npp.2014.18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4023144PMC
June 2014

Spatio-temporal pharmacokinetic model based registration of 4D PET neuroimaging data.

Neuroimage 2014 Jan 28;84:225-35. Epub 2013 Aug 28.

Institute of Biomedical Engineering, Department of Engineering Science, University of Oxford, UK; Imanova Limited, Hammersmith Hospital, London, UK. Electronic address:

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http://dx.doi.org/10.1016/j.neuroimage.2013.08.031DOI Listing
January 2014

Mathematical modelling of [¹¹C]-(+)-PHNO human competition studies.

Neuroimage 2013 Mar 30;68:119-32. Epub 2012 Nov 30.

GlaxoSmithKline Clinical Imaging Centre, Hammersmith Hospital, Du Cane Road, London W12 0NN, UK.

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http://dx.doi.org/10.1016/j.neuroimage.2012.11.033DOI Listing
March 2013

Endogenous opioid release in the human brain reward system induced by acute amphetamine administration.

Biol Psychiatry 2012 Sep 3;72(5):371-7. Epub 2012 Mar 3.

Neuropsychopharmacology Unit, Centre for Pharmacology and Therapeutics, Division of Experimental Medicine, Department of Medicine, Imperial College, London, United Kingdom.

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http://dx.doi.org/10.1016/j.biopsych.2012.01.027DOI Listing
September 2012

Imaging dopamine receptors in humans with [11C]-(+)-PHNO: dissection of D3 signal and anatomy.

Neuroimage 2011 Jan 30;54(1):264-77. Epub 2010 Jun 30.

GlaxoSmithKline, Clinical Imaging Centre, Imperial College, London, UK.

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http://dx.doi.org/10.1016/j.neuroimage.2010.06.044DOI Listing
January 2011

Imaging cortical dopamine D1 receptors using [11C]NNC112 and ketanserin blockade of the 5-HT 2A receptors.

J Cereb Blood Flow Metab 2010 May 23;30(5):985-93. Epub 2009 Dec 23.

Discovery Medicine, Neurosciences Centre of Excellence for Drug Discovery, GlaxoSmithKline, Barcelona, Spain.

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http://dx.doi.org/10.1038/jcbfm.2009.269DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2949183PMC
May 2010