Graeme P Young

Graeme P Young

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Graeme P Young

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Low Sensitivity of Fecal Immunochemical Tests and Blood-Based Markers of DNA Hypermethylation for Detection of Sessile Serrated Adenomas/Polyps.

Dig Dis Sci 2019 Sep 5;64(9):2555-2562. Epub 2019 Mar 5.

Flinders Centre for Innovation in Cancer (FCIC), College of Medicine and Public Health, Flinders University, Bedford Park, SA, Australia.

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http://dx.doi.org/10.1007/s10620-019-05569-8DOI Listing
September 2019

A Randomized Controlled Trial Testing Provision of Fecal and Blood Test Options on Participation for Colorectal Cancer Screening.

Cancer Prev Res (Phila) 2019 Sep 2;12(9):631-640. Epub 2019 Jul 2.

Flinders Centre for Innovation in Cancer, Bedford Park, South Australia, Australia.

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http://dx.doi.org/10.1158/1940-6207.CAPR-19-0089DOI Listing
September 2019

Resistant Starch is Actively Fermented by Infant Faecal Microbiota and Increases Microbial Diversity.

Nutrients 2019 Jun 14;11(6). Epub 2019 Jun 14.

Edith Cowan University, School of Medical & Health Sciences, Joondalup, WA 6027, Australia.

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http://dx.doi.org/10.3390/nu11061345DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6628288PMC
June 2019

Circulating tumour DNA for monitoring colorectal cancer-a prospective cohort study to assess relationship to tissue methylation, cancer characteristics and surgical resection.

Clin Epigenetics 2018 16;10:63. Epub 2018 May 16.

1Flinders Centre for Innovation in Cancer, College of Medicine and Public Health, Flinders University of South Australia, Bedford Park, South Australia 5042 Australia.

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http://dx.doi.org/10.1186/s13148-018-0500-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5956533PMC
May 2019

The Global Paradigm Shift in Screening for Colorectal Cancer.

Gastroenterology 2019 03 16;156(4):843-851.e2. Epub 2019 Feb 16.

Memorial Sloan Kettering Cancer Center, New York, New York.

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https://linkinghub.elsevier.com/retrieve/pii/S00165085193037
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http://dx.doi.org/10.1053/j.gastro.2019.02.006DOI Listing
March 2019

Reducing the number of surveillance colonoscopies with faecal immunochemical tests.

Gut 2019 Feb 26. Epub 2019 Feb 26.

Flinders Centre for Innovation in Cancer, Flinders University, Bedford Park, South Australia, Australia.

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http://dx.doi.org/10.1136/gutjnl-2019-318370DOI Listing
February 2019

The impact of sample type and procedural attributes on relative acceptability of different colorectal cancer screening regimens.

Patient Prefer Adherence 2018 18;12:1825-1836. Epub 2018 Sep 18.

Flinders Centre for Innovation in Cancer, Flinders University, Bedford Park, SA, Australia,

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http://dx.doi.org/10.2147/PPA.S172143DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6154741PMC
September 2018

The Use of Circulating Tumor DNA for Prognosis of Gastrointestinal Cancers.

Front Oncol 2018 24;8:275. Epub 2018 Jul 24.

Flinders Centre for Innovation in Cancer, College of Medicine and Public Health, Flinders University, Bedford Park, SA, Australia.

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http://dx.doi.org/10.3389/fonc.2018.00275DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6066577PMC
July 2018

Demand for Colonoscopy in Colorectal Cancer Screening Using a Quantitative Fecal Immunochemical Test and Age/Sex-Specific Thresholds for Test Positivity.

Cancer Epidemiol Biomarkers Prev 2018 06 28;27(6):704-709. Epub 2018 Mar 28.

Graduate Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei, Taiwan.

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http://dx.doi.org/10.1158/1055-9965.EPI-17-0387DOI Listing
June 2018

Methylation and Gene Expression of and in Colorectal Cancer Tissues.

Clin Med Insights Oncol 2018 10;12:1179554918775064. Epub 2018 May 10.

Flinders Centre for Innovation in Cancer, Flinders University, Bedford Park, SA, Australia.

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http://dx.doi.org/10.1177/1179554918775064DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5952276PMC
May 2018

Web-Based Communication Strategies Designed to Improve Intention to Minimize Risk for Colorectal Cancer: Randomized Controlled Trial.

JMIR Cancer 2018 Feb 12;4(1):e2. Epub 2018 Feb 12.

Sansom Institute for Health Research, Division of Health Sciences, University of South Australia, Adelaide, SA, Australia.

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http://dx.doi.org/10.2196/cancer.8250DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5826979PMC
February 2018

Effect of sample storage temperature and buffer formulation on faecal immunochemical test haemoglobin measurements.

J Med Screen 2017 12 10;24(4):176-181. Epub 2017 Jan 10.

1 Flinders Centre for Innovation in Cancer, Flinders University, Bedford Park, SA, Australia.

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http://dx.doi.org/10.1177/0969141316686808DOI Listing
December 2017

Patterns of participation over four rounds of annual fecal immunochemical test-based screening for colorectal cancer: what predicts rescreening?

BMC Public Health 2017 08 1;18(1):81. Epub 2017 Aug 1.

Flinders Centre for Innovation in Cancer, Flinders University of South Australia, GPO Box 2100, Adelaide, SA, 5001, Australia.

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http://dx.doi.org/10.1186/s12889-017-4634-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5540393PMC
August 2017

Supplementation with Brazil nuts and green tea extract regulates targeted biomarkers related to colorectal cancer risk in humans.

Br J Nutr 2016 Dec 7;116(11):1901-1911. Epub 2016 Dec 7.

1Flinders Centre for Innovation in Cancer,Flinders University,Adelaide,South Australia,Australia.

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http://dx.doi.org/10.1017/S0007114516003937DOI Listing
December 2016

Theory-based modifications of an advanced notification letter improves screening for bowel cancer in men: A randomised controlled trial.

Soc Sci Med 2016 09 1;165:1-9. Epub 2016 Jul 1.

School of Psychology, University of Adelaide, South Australia, Australia; Freemasons Foundation Centre for Men's Health, School of Medicine, The University of Adelaide, Adelaide, Australia.

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http://dx.doi.org/10.1016/j.socscimed.2016.06.036DOI Listing
September 2016

Role of Red Meat and Resistant Starch in Promutagenic Adduct Formation, MGMT Repair, Thymic Lymphoma and Intestinal Tumourigenesis in Msh2 -Deficient Mice.

J Nutrigenet Nutrigenomics 2014 27;7(4-6):299-313. Epub 2015 May 27.

Flinders Centre for Innovation in Cancer, Flinders University, Bedford Park, S.A., Australia.

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http://dx.doi.org/10.1159/000381675DOI Listing
April 2016

Gender differences in faecal haemoglobin concentration.

J Med Screen 2016 Mar 20;23(1):54. Epub 2015 Jul 20.

Repatriation General Hospital, Daws Road, Daw Park, South Australia 5041, Australia.

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http://dx.doi.org/10.1177/0969141315597018DOI Listing
March 2016

A Blood Test for Methylated BCAT1 and IKZF1 vs. a Fecal Immunochemical Test for Detection of Colorectal Neoplasia.

Clin Transl Gastroenterol 2016 Jan 14;7:e137. Epub 2016 Jan 14.

Flinders Centre for Innovation in Cancer, Flinders University of South Australia, South Australia, Australia.

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http://dx.doi.org/10.1038/ctg.2015.67DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4737873PMC
January 2016

Sociodemographic disparities in survival from colorectal cancer in South Australia: a population-wide data linkage study.

BMC Health Serv Res 2016 Jan 20;16:24. Epub 2016 Jan 20.

Centre for Population Health Research, University of South Australia, GPO Box 2471, Adelaide, SA, 5001, Australia.

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http://dx.doi.org/10.1186/s12913-016-1263-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4721049PMC
January 2016

Factors affecting faecal immunochemical test positive rates: demographic, pathological, behavioural and environmental variables.

J Med Screen 2015 Dec 14;22(4):187-93. Epub 2015 May 14.

Flinders Centre for Innovation in Cancer, Flinders University, Bedford Park, South Australia.

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http://msc.sagepub.com/content/22/4/187.full.pdf
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http://dx.doi.org/10.1177/0969141315584783DOI Listing
December 2015

Colorectal cancer screening: a global overview of existing programmes.

Gut 2015 Oct 3;64(10):1637-49. Epub 2015 Jun 3.

Department of Gastroenterology and Hepatology, Erasmus MC, University Medical Centre, Rotterdam, The Netherlands.

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http://gut.bmj.com/content/64/10/1637.full.pdf
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http://gut.bmj.com/lookup/doi/10.1136/gutjnl-2014-309086
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http://dx.doi.org/10.1136/gutjnl-2014-309086DOI Listing
October 2015

A prediction model for colon cancer surveillance data.

Stat Med 2015 Aug 6;34(18):2662-75. Epub 2015 Apr 6.

Department of Biostatistics, University of Michigan, Ann Arbor, MI, U.S.A.

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http://doi.wiley.com/10.1002/sim.6500
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http://dx.doi.org/10.1002/sim.6500DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4494883PMC
August 2015

The potential for zinc stable isotope techniques and modelling to determine optimal zinc supplementation.

Nutrients 2015 May 29;7(6):4271-95. Epub 2015 May 29.

Flinders University of South Australia, Bedford Park, GPO Box 2100, Adelaide SA 5001, Australia.

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http://dx.doi.org/10.3390/nu7064271DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4488783PMC
May 2015

Advances in Fecal Occult Blood Tests: the FIT revolution.

Dig Dis Sci 2015 Mar 10;60(3):609-22. Epub 2014 Dec 10.

Flinders Centre for Innovation in Cancer L3:100, Flinders University, Post Office Box 2100, Adelaide, SA, 5001, Australia,

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http://dx.doi.org/10.1007/s10620-014-3445-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4366567PMC
March 2015

Improving the reporting of evaluations of faecal immunochemical tests for haemoglobin: the FITTER standard and checklist.

Eur J Cancer Prev 2015 Jan;24(1):24-6

aCentre for Research into Cancer Prevention and Screening, Ninewells Hospital and Medical School, University of Dundee, Dundee, Scotland bDivision of Gastroenterology, University of California San Francisco, San Francisco, California, USA cFlinders Centre for Innovation in Cancer, Flinders University, Bedford Park (Adelaide), South Australia dBowel Cancer Screening Hub - South of England, Royal Surrey County Hospital NHS Foundation Trust and University of Surrey, Guildford, Surrey, UK.

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https://insights.ovid.com/crossref?an=00008469-201501000-000
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http://dx.doi.org/10.1097/CEJ.0000000000000016DOI Listing
January 2015

Rising incidence of early-onset colorectal cancer in Australia over two decades: report and review.

J Gastroenterol Hepatol 2015 Jan;30(1):6-13

Department of Haematology and Oncology, The Queen Elizabeth Hospital, Woodville, South Australia, Australia; South Australian Health and Medical Research Institute (SAHMRI) Colorectal Node, Basil Hetzel Institute for Translational Research, Woodville, South Australia, Australia; School of Medicine, University of Adelaide, Adelaide, South Australia, Australia.

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http://dx.doi.org/10.1111/jgh.12792DOI Listing
January 2015

The relevance of the colon to zinc nutrition.

Nutrients 2015 Jan 14;7(1):572-83. Epub 2015 Jan 14.

School of Medicine, Flinders University of South Australia, Adelaide 5001, Australia.

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http://dx.doi.org/10.3390/nu7010572DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4303854PMC
January 2015

Zinc deficiency in children with environmental enteropathy-development of new strategies: report from an expert workshop.

Am J Clin Nutr 2014 Oct 13;100(4):1198-207. Epub 2014 Aug 13.

From the School of Medicine, Flinders University of South Australia, Adelaide, Australia (GPY, EKM, GLG, and ILB); Washington University School of Medicine, St Louis, MO (DHA and MJM); Yale University School of Medicine, New Haven, CT (HJB); the Department of Medical Gastroenterology, Christian Medical College Vellore, Vellore, India (BSR); and Enteric and Diarrheal Diseases, the Bill & Melinda Gates Foundation, Seattle, WA (TGB).

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http://dx.doi.org/10.3945/ajcn.113.075036DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4163797PMC
October 2014

CAHM, a long non-coding RNA gene hypermethylated in colorectal neoplasia.

Epigenetics 2014 Aug 6;9(8):1071-82. Epub 2014 May 6.

CSIRO Preventative Health Flagship; Animal, Food & Health Sciences Division; North Ryde, NSW Australia.

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http://dx.doi.org/10.4161/epi.29046DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4164492PMC
August 2014

Treatment patterns among colorectal cancer patients in South Australia: a demonstration of the utility of population-based data linkage.

J Eval Clin Pract 2014 Aug 22;20(4):467-77. Epub 2014 May 22.

School of Population Health, Facility of Health Sciences, University of Adelaide, Adelaide, Australia.

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http://dx.doi.org/10.1111/jep.12183DOI Listing
August 2014

Dietary manipulation of oncogenic microRNA expression in human rectal mucosa: a randomized trial.

Cancer Prev Res (Phila) 2014 Aug;7(8):786-95

Preventative Health National Research Flagship, CSIRO, and CSIRO Animal, Food and Health Sciences, Adelaide, South Australia, Australia.

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http://dx.doi.org/10.1158/1940-6207.CAPR-14-0053DOI Listing
August 2014

Colorectal cancer survival: An analysis of patients with metastatic disease synchronous and metachronous with the primary tumor.

Clin Colorectal Cancer 2014 Jun 13;13(2):87-93. Epub 2013 Nov 13.

Department of Medical Oncology, Flinders Centre for Innovation in Cancer, Flinders Medical Centre, Bedford Park, Australia; Flinders Centre for Innovation in Cancer, Flinders University, Bedford Park, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.clcc.2013.11.008DOI Listing
June 2014

Accumulation of promutagenic DNA adducts in the mouse distal colon after consumption of heme does not induce colonic neoplasms in the western diet model of spontaneous colorectal cancer.

Mol Nutr Food Res 2014 Mar 1;58(3):550-8. Epub 2013 Oct 1.

Flinders Centre for Innovation in Cancer, Flinders University, Adelaide, South Australia, Australia.

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http://doi.wiley.com/10.1002/mnfr.201300430
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http://dx.doi.org/10.1002/mnfr.201300430DOI Listing
March 2014

A standard for Faecal Immunochemical TesTs for haemoglobin evaluation reporting (FITTER).

Ann Clin Biochem 2014 Mar 17;51(Pt 2):301-2. Epub 2013 Dec 17.

Centre for Research into Cancer Prevention and Screening, University of Dundee, Scotland.

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http://journals.sagepub.com/doi/10.1177/0004563213514392
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http://dx.doi.org/10.1177/0004563213514392DOI Listing
March 2014

Oral rehydration therapy in the second decade of the twenty-first century.

Curr Gastroenterol Rep 2014 Mar;16(3):376

Department of Internal Medicine, Yale School of Medicine, P.O. Box 208019, New Haven, CT, 06520, USA,

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http://dx.doi.org/10.1007/s11894-014-0376-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3950600PMC
March 2014

Dietary red meat aggravates dextran sulfate sodium-induced colitis in mice whereas resistant starch attenuates inflammation.

Dig Dis Sci 2013 Dec 29;58(12):3475-82. Epub 2013 Aug 29.

Preventative Health National Research Flagship, CSIRO, and CSIRO Animal, Food and Health Sciences, Adelaide, SA, Australia,

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http://dx.doi.org/10.1007/s10620-013-2844-1DOI Listing
December 2013

Ambivalence and its influence on participation in screening for colorectal cancer.

Qual Health Res 2013 Sep 5;23(9):1188-201. Epub 2013 Aug 5.

University of Adelaide, Adelaide, South Australia, Australia.

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http://dx.doi.org/10.1177/1049732313501890DOI Listing
September 2013

Comparing the effects of COX and non-COX-inhibiting NSAIDs on enhancement of apoptosis and inhibition of aberrant crypt foci formation in a rat colorectal cancer model.

Anticancer Res 2013 Sep;33(9):3581-8

Flinders Centre for Innovation in Cancer, GPO Box 2100, Adelaide, SA 5001, Australia.

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September 2013

Quantitation of hemoglobin improves fecal immunochemical tests for noninvasive screening.

Clin Gastroenterol Hepatol 2013 Jul 13;11(7):839-40. Epub 2013 Apr 13.

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http://dx.doi.org/10.1016/j.cgh.2013.02.031DOI Listing
July 2013

Shift to earlier stage at diagnosis as a consequence of the National Bowel Cancer Screening Program.

Med J Aust 2013 Apr;198(6):327-30

Bowel Health Service, Repatriation General Hospital, Adelaide, SA.

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http://dx.doi.org/10.5694/mja12.11357DOI Listing
April 2013

Sensitive and selective amplification of methylated DNA sequences using helper-dependent chain reaction in combination with a methylation-dependent restriction enzymes.

Nucleic Acids Res 2013 Jan 10;41(1):e15. Epub 2012 Sep 10.

CSIRO Animal, Food and Health Sciences, Preventative Health Flagship, North Ryde, NSW 1670, Australia.

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http://dx.doi.org/10.1093/nar/gks831DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3592453PMC
January 2013

Using the Transtheoretical Model of Behaviour Change to describe readiness to rescreen for colorectal cancer with faecal occult blood testing.

Health Promot J Austr 2012 Aug;23(2):122-8

School of Psychology, The University of Adelaide, South Australia.

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August 2012

Guaiac based faecal occult blood testing for colorectal cancer screening: an obsolete strategy?

Gut 2012 Jul 16;61(7):959-60. Epub 2012 Feb 16.

Flinders Centre for Innovation in Cancer, Flinders University, Adelaide, South Australia, Australia.

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http://dx.doi.org/10.1136/gutjnl-2011-301810DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3355341PMC
July 2012

The urgency of saving lives through bowel cancer screening.

Med J Aust 2012 May;196(8):490-1

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http://dx.doi.org/10.5694/mja12.10476DOI Listing
May 2012

Selenium-rich foods: a promising approach to colorectal cancer prevention.

Curr Pharm Biotechnol 2012 Jan;13(1):165-72

Department of Medicine/ Gastroenterology, Flinders Centre for Cancer Prevention and Control, Flinders University of South Australia, Adelaide 5042, Australia.

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http://dx.doi.org/10.2174/138920112798868809DOI Listing
January 2012

Butyrate delivered by butyrylated starch increases distal colonic epithelial apoptosis in carcinogen-treated rats.

Carcinogenesis 2012 Jan 10;33(1):197-202. Epub 2011 Nov 10.

Preventative Health National Research Flagship, Commonwealth Scientific and Industrial Research Organisation (CSIRO) Food and Nutritional Sciences, PO Box 10041, Adelaide BC, Adelaide, South Australia 5000, Australia.

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http://dx.doi.org/10.1093/carcin/bgr254DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3276328PMC
January 2012

Psychosocial variables associated with colorectal cancer screening in South Australia.

Int J Behav Med 2011 Dec;18(4):302-9

Bowel Health Service, Repatriation General Hospital Daw Park, Daws Road, Daw Park, 5041 South Australia, Australia.

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http://dx.doi.org/10.1007/s12529-010-9101-1DOI Listing
December 2011

Inhibition by resistant starch of red meat-induced promutagenic adducts in mouse colon.

Cancer Prev Res (Phila) 2011 Nov 1;4(11):1920-8. Epub 2011 Sep 1.

Flinders Centre for Cancer Prevention and Control, Flinders University of South Australia, Bedford Park.

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http://dx.doi.org/10.1158/1940-6207.CAPR-11-0176DOI Listing
November 2011

Colorectal cancer screening in rural and remote areas: analysis of the National Bowel Cancer Screening Program data for South Australia.

Rural Remote Health 2011 12;11(2):1648. Epub 2011 May 12.

Discipline of Public Health, Flinders University, Adelaide, South Australia, Australia.

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September 2011

The influence of selenium-enriched milk proteins and selenium yeast on plasma selenium levels and rectal selenoprotein gene expression in human subjects.

Br J Nutr 2011 Aug 30;106(4):572-82. Epub 2011 Mar 30.

Flinders Centre for Cancer Prevention and Control, Flinders University of South Australia, Adelaide, SA, Australia.

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http://www.journals.cambridge.org/abstract_S0007114511000420
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http://dx.doi.org/10.1017/S0007114511000420DOI Listing
August 2011

Fecal Tests: From Blood to Molecular Markers.

Curr Colorectal Cancer Rep 2011 Mar 18;7(1):62-70. Epub 2011 Jan 18.

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http://dx.doi.org/10.1007/s11888-010-0084-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3029665PMC
March 2011

DNA methylation in the rectal mucosa is associated with crypt proliferation and fecal short-chain fatty acids.

Dig Dis Sci 2011 Feb 16;56(2):387-96. Epub 2010 Jul 16.

Conjoint Gastroenterology Laboratory, Royal Brisbane and Women's Hospital Research Foundation Clinical Research Centre, Brisbane, QLD, Australia.

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http://dx.doi.org/10.1007/s10620-010-1312-4DOI Listing
February 2011

Interval fecal immunochemical testing in a colonoscopic surveillance program speeds detection of colorectal neoplasia.

Gastroenterology 2010 Dec 16;139(6):1918-26. Epub 2010 Aug 16.

Flinders Centre for Cancer Prevention and Control, Flinders University of South Australia, Bedford Park (Adelaide), South Australia.

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https://linkinghub.elsevier.com/retrieve/pii/S00165085100122
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http://dx.doi.org/10.1053/j.gastro.2010.08.005DOI Listing
December 2010

Protocol for population testing of an Internet-based Personalised Decision Support system for colorectal cancer screening.

BMC Med Inform Decis Mak 2010 Sep 16;10:50. Epub 2010 Sep 16.

Flinders Centre for Cancer Prevention and Control, School of Medicine, Flinders University, Sturt Road, Bedford Park, SA 5042, Australia.

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http://dx.doi.org/10.1186/1472-6947-10-50DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2949693PMC
September 2010

Selenium-enriched milk proteins and selenium yeast affect selenoprotein activity and expression differently in mouse colon.

Br J Nutr 2010 Jul 29;104(1):17-23. Epub 2010 Mar 29.

Flinders Centre for Cancer Prevention and Control, Flinders University of South Australia, Bedford Park 5042, Australia.

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http://dx.doi.org/10.1017/S0007114510000309DOI Listing
July 2010

R-flurbiprofen suppresses distal nonmucin-producing colorectal tumors in azoxymethane-treated rats, without suppressing eicosanoid production.

Am J Physiol Gastrointest Liver Physiol 2010 Jun 25;298(6):G860-4. Epub 2010 Mar 25.

Flinders Ctr. for Cancer Prevention and Control, Flinders Univ., South Australia, 5042.

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http://dx.doi.org/10.1152/ajpgi.00330.2009DOI Listing
June 2010