Graeme J Sills

Graeme J Sills

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Graeme J Sills

Graeme J Sills

Publications by authors named "Graeme J Sills"

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Sulthiame add-on therapy for epilepsy.

Cochrane Database Syst Rev 2019 08 27;8:CD009472. Epub 2019 Aug 27.

Department of Molecular and Clinical Pharmacology, Institute of Translational Medicine, University of Liverpool, Lower Lane, Liverpool, UK, L9 7LJ.

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http://dx.doi.org/10.1002/14651858.CD009472.pub4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6710989PMC
August 2019

A Caenorhabditis elegans assay of seizure-like activity optimised for identifying antiepileptic drugs and their mechanisms of action.

J Neurosci Methods 2018 11 3;309:132-142. Epub 2018 Sep 3.

Department of Cellular and Molecular Physiology, Institute of Translational Medicine, University of Liverpool, Liverpool, UK. Electronic address:

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http://dx.doi.org/10.1016/j.jneumeth.2018.09.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6200019PMC
November 2018

Rare coding variants in genes encoding GABA receptors in genetic generalised epilepsies: an exome-based case-control study.

Authors:
Patrick May Simon Girard Merle Harrer Dheeraj R Bobbili Julian Schubert Stefan Wolking Felicitas Becker Pamela Lachance-Touchette Caroline Meloche Micheline Gravel Cristina E Niturad Julia Knaus Carolien De Kovel Mohamad Toliat Anne Polvi Michele Iacomino Rosa Guerrero-López Stéphanie Baulac Carla Marini Holger Thiele Janine Altmüller Kamel Jabbari Ann-Kathrin Ruppert Wiktor Jurkowski Dennis Lal Raffaella Rusconi Sandrine Cestèle Benedetta Terragni Ian D Coombs Christopher A Reid Pasquale Striano Hande Caglayan Auli Siren Kate Everett Rikke S Møller Helle Hjalgrim Hiltrud Muhle Ingo Helbig Wolfram S Kunz Yvonne G Weber Sarah Weckhuysen Peter De Jonghe Sanjay M Sisodiya Rima Nabbout Silvana Franceschetti Antonietta Coppola Maria S Vari Dorothée Kasteleijn-Nolst Trenité Betul Baykan Ugur Ozbek Nerses Bebek Karl M Klein Felix Rosenow Dang K Nguyen François Dubeau Lionel Carmant Anne Lortie Richard Desbiens Jean-François Clément Cécile Cieuta-Walti Graeme J Sills Pauls Auce Ben Francis Michael R Johnson Anthony G Marson Bianca Berghuis Josemir W Sander Andreja Avbersek Mark McCormack Gianpiero L Cavalleri Norman Delanty Chantal Depondt Martin Krenn Fritz Zimprich Sarah Peter Marina Nikanorova Robert Kraaij Jeroen van Rooij Rudi Balling M Arfan Ikram André G Uitterlinden Giuliano Avanzini Stephanie Schorge Steven Petrou Massimo Mantegazza Thomas Sander Eric LeGuern Jose M Serratosa Bobby P C Koeleman Aarno Palotie Anna-Elina Lehesjoki Michael Nothnagel Peter Nürnberg Snezana Maljevic Federico Zara Patrick Cossette Roland Krause Holger Lerche

Lancet Neurol 2018 08 17;17(8):699-708. Epub 2018 Jul 17.

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http://dx.doi.org/10.1016/S1474-4422(18)30215-1DOI Listing
August 2018

Prospective clinical trials to investigate clinical and molecular biomarkers.

Epilepsia 2017 07;58 Suppl 3:20-26

Department of Molecular & Clinical Pharmacology, Institute of Translational Medicine, University of Liverpool, Liverpool, United Kingdom.

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http://dx.doi.org/10.1111/epi.13782DOI Listing
July 2017

Clinical Drug Development in Epilepsy Revisited: A Proposal for a New Paradigm Streamlined Using Extrapolation.

CNS Drugs 2016 11;30(11):1011-1017

MRC North-West Hub for Trials Methodology Research, Department of Mathematics and Statistics, Fylde College, Lancaster University, Lancaster, LA1 4YF, UK.

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http://dx.doi.org/10.1007/s40263-016-0383-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5078157PMC
November 2016

NRSF and BDNF polymorphisms as biomarkers of cognitive dysfunction in adults with newly diagnosed epilepsy.

Epilepsy Behav 2016 Jan 17;54:117-27. Epub 2015 Dec 17.

Department of Molecular and Clinical Pharmacology, Institute of Translational Medicine, University of Liverpool, Liverpool L69 3GL, UK. Electronic address:

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http://dx.doi.org/10.1016/j.yebeh.2015.11.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4732989PMC
January 2016

Sulthiame add-on therapy for epilepsy.

Cochrane Database Syst Rev 2015 Oct 28(10):CD009472. Epub 2015 Oct 28.

The Walton Centre for Neurology & Neurosurgery NHS Foundation Trust, Lower Lane, Fazakerley, Liverpool, UK, L9 7LJ.

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http://dx.doi.org/10.1002/14651858.CD009472.pub3DOI Listing
October 2015

Validation of a multigenic model to predict seizure control in newly treated epilepsy.

Epilepsy Res 2014 Dec 16;108(10):1797-805. Epub 2014 Sep 16.

Department of Molecular and Clinical Pharmacology, University of Liverpool, Liverpool, UK. Electronic address:

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http://dx.doi.org/10.1016/j.eplepsyres.2014.08.022DOI Listing
December 2014

What are the arguments for and against rational therapy for epilepsy?

Adv Exp Med Biol 2014 ;813:295-308

Anticonvulsant Drug Development Program, Department of Pharmacology and Toxicology, University of Utah, 417 Wakara Way, Suite 3211, Salt Lake City, UT, 84108, USA,

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http://dx.doi.org/10.1007/978-94-017-8914-1_24DOI Listing
November 2014

A comprehensive neuropsychological description of cognition in drug-refractory juvenile myoclonic epilepsy.

Epilepsy Behav 2014 Jul 2;36:124-9. Epub 2014 Jun 2.

Wales Epilepsy Research Network (WERN), College of Medicine, Swansea University, Swansea SA2 8PP, UK. Electronic address:

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http://dx.doi.org/10.1016/j.yebeh.2014.04.027DOI Listing
July 2014

Pharmacogenetics of antiepileptic drug-induced hypersensitivity.

Pharmacogenomics 2014 Apr;15(6):857-68

The Wolfson Centre for Personalised Medicine, Department of Molecular & Clinical Pharmacology, University of Liverpool, Block A: Waterhouse Buildings, 1-5 Brownlow Street, Liverpool, L69 3GL, UK.

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http://dx.doi.org/10.2217/pgs.14.65DOI Listing
April 2014

Sulthiame monotherapy for epilepsy.

Cochrane Database Syst Rev 2014 Mar 9(3):CD010062. Epub 2014 Mar 9.

The Walton Centre for Neurology & Neurosurgery NHS Foundation Trust, Lower Lane, Fazakerley, Liverpool, UK, L9 7LJ.

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http://dx.doi.org/10.1002/14651858.CD010062.pub2DOI Listing
March 2014

Issues related to development of new antiseizure treatments.

Epilepsia 2013 Aug;54 Suppl 4:24-34

Anticonvulsant Drug Development Program, Department of Pharmacology & Toxicology, University of Utah, Salt Lake City, Utah 84108, USA.

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http://dx.doi.org/10.1111/epi.12296DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3947404PMC
August 2013

Prevalence of neurologic autoantibodies in cohorts of patients with new and established epilepsy.

Epilepsia 2013 Jun 6;54(6):1028-35. Epub 2013 Mar 6.

Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, Oxford, United Kingdom.

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http://dx.doi.org/10.1111/epi.12127DOI Listing
June 2013

Sulthiame add-on therapy for epilepsy.

Cochrane Database Syst Rev 2013 Mar 28(3):CD009472. Epub 2013 Mar 28.

The Walton Centre for Neurology & Neurosurgery NHS Trust, Liverpool, UK.

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http://dx.doi.org/10.1002/14651858.CD009472.pub2DOI Listing
March 2013

N (w) -propyl-L-arginine (L-NPA) reduces status epilepticus and early epileptogenic events in a mouse model of epilepsy: behavioural, EEG and immunohistochemical analyses.

Eur J Neurosci 2012 Nov 4;36(9):3194-203. Epub 2012 Sep 4.

Institute of Ageing and Chronic Disease, Faculty of Health and Life Sciences, University of Liverpool, 4th floor Room 4.306, UCD Duncan Building, Daulby Street, Liverpool L69 3GA, UK.

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http://dx.doi.org/10.1111/j.1460-9568.2012.08234.xDOI Listing
November 2012

Antiepileptic drug therapy: does mechanism of action matter?

Epilepsy Behav 2011 Aug 16;21(4):331-41. Epub 2011 Jul 16.

Epilepsy Unit, Western Infirmary, Glasgow, UK.

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http://dx.doi.org/10.1016/j.yebeh.2011.05.025DOI Listing
August 2011

Combining antiepileptic drugs--rational polytherapy?

Seizure 2011 Jun 8;20(5):369-75. Epub 2011 Feb 8.

Epilepsy Unit, Western Infirmary, Glasgow, Scotland, United Kingdom.

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https://linkinghub.elsevier.com/retrieve/pii/S10591311110001
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http://dx.doi.org/10.1016/j.seizure.2011.01.004DOI Listing
June 2011

Response to drug treatment in newly diagnosed epilepsy: a pilot study of (1)H NMR- and MS-based metabonomic analysis.

Epilepsy Res 2010 Feb 11;88(2-3):189-95. Epub 2009 Dec 11.

Strathclyde Institute for Pharmaceutical & Biomedical Sciences, University of Strathclyde, Glasgow, UK.

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http://linkinghub.elsevier.com/retrieve/pii/S092012110900345
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http://dx.doi.org/10.1016/j.eplepsyres.2009.11.005DOI Listing
February 2010

Binasal visual field defects are not specific to vigabatrin.

Epilepsy Behav 2009 Nov 7;16(3):521-6. Epub 2009 Oct 7.

Tennent Institute of Ophthalmology, Gartnavel General Hospital, Glasgow, Scotland, UK.

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http://dx.doi.org/10.1016/j.yebeh.2009.09.003DOI Listing
November 2009

Genetic variants in microsomal epoxide hydrolase influence carbamazepine dosing.

Clin Neuropharmacol 2009 Jul-Aug;32(4):205-12

Epilepsy Unit, Section of Clinical Pharmacology & Stroke Medicine, University Division of Cardiovascular & Medical Sciences, Western Infirmary, Glasgow, Scotland.

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http://dx.doi.org/10.1097/WNF.0b013e318187972aDOI Listing
October 2009

High resolution micro-SPECT scanning in rats using 125I beta-CIT: effects of chronic treatment with carbamazepine.

Epilepsia 2009 Aug 12;50(8):1962-70. Epub 2009 May 12.

Epilepsy Unit, Division of Cardiovascular & Medical Sciences, University of Glasgow, Glasgow, United Kingdom.

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http://dx.doi.org/10.1111/j.1528-1167.2009.02095.xDOI Listing
August 2009

Comparison of different water-miscible solvents for the preparation of plasma and urine samples in metabolic profiling studies.

Talanta 2008 Jan 14;74(4):1060-5. Epub 2007 Aug 14.

Strathclyde Institute for Pharmaceutical and Biomedical Sciences, Strathclyde University, 27 Taylor Street, Glasgow G4 0NR, United Kingdom.

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https://linkinghub.elsevier.com/retrieve/pii/S00399140070052
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http://dx.doi.org/10.1016/j.talanta.2007.07.037DOI Listing
January 2008

Sodium valproate versus lamotrigine: a randomised comparison of efficacy, tolerability and effects on circulating androgenic hormones in newly diagnosed epilepsy.

Epilepsy Res 2007 Jul 5;75(2-3):122-9. Epub 2007 Jun 5.

Epilepsy Unit, University Division of Cardiovascular & Medical Sciences, Western Infirmary, Glasgow G11 6NT, Scotland, UK.

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http://dx.doi.org/10.1016/j.eplepsyres.2007.04.009DOI Listing
July 2007

Predictors of pharmacoresistant epilepsy.

Epilepsy Res 2007 Jul;75(2-3):192-6

Epilepsy Unit, Division of Cardiovascular and Medical Sciences, Western Infirmary, Glasgow G11 6NT, Scotland, UK.

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http://dx.doi.org/10.1016/j.eplepsyres.2007.06.003DOI Listing
July 2007

Sudden unexpected death in epilepsy: a search for risk factors.

Epilepsy Behav 2007 Feb 29;10(1):138-41. Epub 2006 Dec 29.

Epilepsy Unit, Western Infirmary, Glasgow G11 6NT, Scotland, UK.

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http://dx.doi.org/10.1016/j.yebeh.2006.11.010DOI Listing
February 2007

The mechanisms of action of gabapentin and pregabalin.

Authors:
Graeme J Sills

Curr Opin Pharmacol 2006 Feb 22;6(1):108-13. Epub 2005 Dec 22.

Epilepsy Unit Division of Cardiovascular & Medical Sciences, Western Infirmary, Glasgow G11 6NT, Scotland.

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http://dx.doi.org/10.1016/j.coph.2005.11.003DOI Listing
February 2006

Lack of association between the C3435T polymorphism in the human multidrug resistance (MDR1) gene and response to antiepileptic drug treatment.

Epilepsia 2005 May;46(5):643-7

Epilepsy Unit, Section of Clinical Pharmacology & Stroke Medicine, University Division of Cardiovascular & Medical Sciences, Western Infirmary, Glasgow, Scotland.

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http://dx.doi.org/10.1111/j.1528-1167.2005.46304.xDOI Listing
May 2005

Pharmacodynamic interaction studies with topiramate in the pentylenetetrazol and maximal electroshock seizure models.

Seizure 2004 Jul;13(5):287-95

Epilepsy Unit, Clinical Pharmacology Section, University Division of Cardiovascular and Medical Sciences, Western Infirmary, Glasgow G11 6NT, Scotland, UK.

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http://dx.doi.org/10.1016/S1059-1311(03)00185-7DOI Listing
July 2004

Vigabatrin, but not gabapentin or topiramate, produces concentration-related effects on enzymes and intermediates of the GABA shunt in rat brain and retina.

Epilepsia 2003 Jul;44(7):886-92

Epilepsy Unit, University Department of Medicine and Therapeutics, Western Infirmary, Glasgow, Scotland.

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http://dx.doi.org/10.1046/j.1528-1157.2003.04203.xDOI Listing
July 2003

Differential expression of multidrug resistance genes in naïve rat brain.

Neurosci Lett 2003 Mar;339(1):33-6

Epilepsy Unit, University Department of Medicine and Therapeutics, Western Infirmary, G11 6NT, Scotland, Glasgow, United Kingdom.

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http://dx.doi.org/10.1016/s0304-3940(02)01453-2DOI Listing
March 2003

Pre-clinical studies with the GABAergic compounds vigabatrin and tiagabine.

Authors:
Graeme J Sills

Epileptic Disord 2003 Mar;5(1):51-6

Epilepsy Unit, Department of Medicine and Therapeutics, Western Infirmary, Glasgow, Scotland, United Kingdom.

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March 2003

Regional expression of multidrug resistance genes in genetically epilepsy-prone rat brain after a single audiogenic seizure.

Epilepsia 2002 Nov;43(11):1318-23

Epilepsy Unit, University Department of Medicine and Therapeutics, Western Infirmary, Glasgow, Scotland.

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http://dx.doi.org/10.1046/j.1528-1157.2002.156702.xDOI Listing
November 2002

P-glycoprotein-mediated efflux of antiepileptic drugs: preliminary studies in mdr1a knockout mice.

Epilepsy Behav 2002 Oct;3(5):427-432

Epilepsy Unit, University Department of Medicine and Therapeutics, Western Infirmary, Glasgow, Scotland, UK

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http://dx.doi.org/10.1016/s1525-5050(02)00511-5DOI Listing
October 2002

Influence of cytochrome P450 induction on the pharmacokinetics and pharmacodynamics of remacemide hydrochloride.

Epilepsy Res 2002 May;49(3):247-54

Epilepsy Unit, University Department of Medicine and Therapeutics, Western Infirmary, Glasgow G116NT, UK.

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http://dx.doi.org/10.1016/s0920-1211(02)00049-9DOI Listing
May 2002

Topiramate in patients with learning disability and refractory epilepsy.

Epilepsia 2002 Apr;43(4):399-402

Epilepsy Unit, University Department of Medicine and Therapeutics, Western Infirmary, Glasgow G11 6NT, Scotland, UK.

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http://dx.doi.org/10.1046/j.1528-1157.2002.47401.xDOI Listing
April 2002

Differential effects of remacemide and desglycinyl-remacemide on epileptiform burst firing in the rat hippocampal slice.

Neurosci Lett 2002 Mar;321(1-2):33-6

Epilepsy Unit, University Department of Medicine and Therapeutics, Western Infirmary, Glasgow G11 6NT, Scotland, UK.

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http://dx.doi.org/10.1016/s0304-3940(01)02511-3DOI Listing
March 2002

Na(+) channel effects of remacemide and desglycinyl-remacemide in rat cortical synaptosomes.

Eur J Pharmacol 2002 Mar;438(1-2):63-8

Epilepsy Unit, University Department of Medicine and Therapeutics, Western Infirmary, Glasgow G11 6NT, Scotland, UK.

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http://dx.doi.org/10.1016/s0014-2999(02)01297-9DOI Listing
March 2002