Graeme J O'Keefe

Graeme J O'Keefe

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Graeme J O'Keefe

Graeme J O'Keefe

Publications by authors named "Graeme J O'Keefe"

28Publications

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1PubMed Central Citations

Spatial and quantitative mapping of glycolysis and hypoxia in glioblastoma as a predictor of radiotherapy response and sites of relapse.

Eur J Nucl Med Mol Imaging 2020 Feb 5. Epub 2020 Feb 5.

Department of Molecular Imaging and Therapy, Austin Health, Heidelberg, Victoria, Australia.

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http://dx.doi.org/10.1007/s00259-020-04706-0DOI Listing
February 2020

and Evaluation of Zr-DS-8273a as a Theranostic for Anti-Death Receptor 5 Therapy.

Theranostics 2016 25;6(12):2225-2234. Epub 2016 Sep 25.

Tumour Targeting Laboratory, Olivia Newton-John Cancer Research Institute, Melbourne, Australia;; School of Cancer Medicine, La Trobe University, Melbourne, Australia;; Department of Medicine, University of Melbourne, Melbourne, Australia;; Department of Medical Oncology, Austin Health, Heidelberg, Melbourne, Australia;; Department of Molecular Imaging and Therapy, Austin Health, Melbourne, Australia.

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http://dx.doi.org/10.7150/thno.16260DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5135445PMC
October 2017

Engineering anti-Lewis-Y hu3S193 antibodies with improved therapeutic ratio for radioimmunotherapy of epithelial cancers.

EJNMMI Res 2016 Dec 17;6(1):26. Epub 2016 Mar 17.

Tumour Targeting Laboratory, Ludwig Institute for Cancer Research and Olivia Newton-John Cancer Research Institute, Melbourne, VIC, Australia.

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http://dx.doi.org/10.1186/s13550-016-0180-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4796444PMC
December 2016

L-Tyrosine Confers Residualizing Properties to a d-Amino Acid-Rich Residualizing Peptide for Radioiodination of Internalizing Antibodies.

Mol Imaging 2016 25;15. Epub 2016 Jul 25.

Tumour Targeting Program, Ludwig Institute For Cancer Research and Olivia Newton-John Cancer Research Institute, Heidelberg, Victoria, Australia Department of Nuclear Medicine and Centre for PET, Austin Health, Heidelberg, Victoria, Australia.

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http://dx.doi.org/10.1177/1536012116647535DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5470130PMC
December 2016

Fluorine-18 radiolabeling of a nitrophenyl sulfoxide and its evaluation in an SK-RC-52 model of tumor hypoxia.

J Labelled Comp Radiopharm 2016 08 19;59(10):416-23. Epub 2016 Jul 19.

Bio21 Institute, The University of Melbourne, Melbourne, Australia.

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http://dx.doi.org/10.1002/jlcr.3426DOI Listing
August 2016

In vivo imaging of cellular proliferation in renal cell carcinoma using 18F-fluorothymidine PET.

Asia Ocean J Nucl Med Biol 2014 ;2(1):3-11

Centre for PET, Austin Hospital, Heidelberg, Victoria, Australia; Ludwig Institute for Cancer Research, Austin Hospital, Heidelberg, Victoria, Australia; Department of Medicine, University of Melbourne, Austin Hospital, Heidelberg, Victoria, Australia.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4937709PMC
July 2016

Molecular Imaging and Quantitation of EphA2 Expression in Xenograft Models with 89Zr-DS-8895a.

J Nucl Med 2016 06 3;57(6):974-80. Epub 2016 Mar 3.

Tumour Targeting Laboratory, Ludwig Institute for Cancer Research and Olivia Newton-John Cancer Research Institute, Melbourne, Australia Department of Medical Oncology, Austin Health, Heidelberg, Melbourne, Australia Department of Molecular Imaging and Therapy, Austin Health, Melbourne, Australia Department of Medicine, University of Melbourne, Melbourne, Australia

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http://dx.doi.org/10.2967/jnumed.115.169839DOI Listing
June 2016

Toward hypoxia-selective rhenium and technetium tricarbonyl complexes.

Inorg Chem 2015 Oct 16;54(19):9594-610. Epub 2015 Sep 16.

Ludwig Institute for Cancer Research , Melbourne-Austin Branch, 145 Studley Road, Heidelberg, Victoria 3084, Australia.

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http://dx.doi.org/10.1021/acs.inorgchem.5b01691DOI Listing
October 2015

Phase I Imaging and Pharmacodynamic Trial of CS-1008 in Patients With Metastatic Colorectal Cancer.

J Clin Oncol 2015 Aug 29;33(24):2609-16. Epub 2015 Jun 29.

Marika Ciprotti, Niall C. Tebbutt, Fook-Thean Lee, Sze-Ting Lee, Hui K. Gan, Wendie Hopkins, Fiona E. Scott, Andrew M. Scott, Ludwig Institute for Cancer Research; David C. McKee, Graeme J. O'Keefe, Sylvia J. Gong, Geoffrey Chong, Bridget Chappell, Andrew M. Scott, Austin Health, Melbourne, Australia; Martin W. Brechbiel, National Cancer Institute, Bethesda, MD; Archie N. Tse, Jonathan Greenberg, Daiichi Sankyo Co., Ltd, Parsippany, NJ; Mendel Jansen, Daiichi Sankyo Development Ltd, Gerrards Cross, Buckinghamshire, United Kingdom; Manabu Matsumura, Masakatsu Kotsuma, Rira Watanabe, Daiichi Sankyo Co., Ltd, Tokyo, Japan; Robert A. Beckman, Georgetown University Medical Center and Ralph Venhaus, Ludwig Institute for Cancer Research, New York, NY.

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http://ascopubs.org/doi/10.1200/JCO.2014.60.4256
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http://dx.doi.org/10.1200/JCO.2014.60.4256DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4881374PMC
August 2015

Radiolabelling and evaluation of a novel sulfoxide as a PET imaging agent for tumor hypoxia.

Nucl Med Biol 2014 May-Jun;41(5):419-25. Epub 2014 Mar 12.

Centre for PET, Austin Health, Level 1 HSB, 145 Studley Road, Heidelberg VIC 3084, Australia; Ludwig Institute for Cancer Research, Melbourne - Austin Branch, Heidelberg VIC 3084, Australia; School of Medicine, Dentistry and Health Sciences, The University of Melbourne, Melbourne VIC 3010, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.nucmedbio.2014.03.001DOI Listing
December 2014

Effect of voxel size when calculating patient specific radionuclide dosimetry estimates using direct Monte Carlo simulation.

Australas Phys Eng Sci Med 2014 Sep 25;37(3):495-503. Epub 2014 May 25.

Centre for PET, Austin Health, Studley Rd, Heidelberg, VIC, 3084, Australia,

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http://dx.doi.org/10.1007/s13246-014-0277-6DOI Listing
September 2014

Molecular imaging of death receptor 5 occupancy and saturation kinetics in vivo by humanized monoclonal antibody CS-1008.

Clin Cancer Res 2013 Nov 17;19(21):5984-93. Epub 2013 Sep 17.

Authors' Affiliations: Tumour Targeting Laboratory and Oncogenic Transcription Laboratory, Ludwig Institute for Cancer Research; Department of Nuclear Medicine and Centre for PET, Austin Health, Melbourne, Australia; Radioimmune & Inorganic Chemistry Section, Radiation Oncology Branch, Cancer Research Centre, Bethesda, Maryland; Clinical Development-Oncology, Daiichi Sankyo Pharmaceutical Development, Edison, New Jersey; and Global Project Management Department, Daiichi Sankyo Co. Ltd., Tokyo, Japan.

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http://dx.doi.org/10.1158/1078-0432.CCR-12-3104DOI Listing
November 2013

Radiolabelling and evaluation of novel haloethylsulfoxides as PET imaging agents for tumor hypoxia.

Nucl Med Biol 2012 Aug 14;39(6):871-82. Epub 2012 Feb 14.

School of Chemistry and Bio21 Institute, The University of Melbourne, Parkville, Victoria 3052, Australia.

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http://dx.doi.org/10.1016/j.nucmedbio.2012.01.004DOI Listing
August 2012

Relationship between atrophy and beta-amyloid deposition in Alzheimer disease.

Ann Neurol 2010 Mar;67(3):317-24

Department of Nuclear Medicine and Center for PET, Austin Health, 145 Studley Road, Heidelberg, Victoria 3084, Australia.

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http://dx.doi.org/10.1002/ana.21955DOI Listing
March 2010

Radiation dosimetry of beta-amyloid tracers 11C-PiB and 18F-BAY94-9172.

J Nucl Med 2009 Feb 21;50(2):309-15. Epub 2009 Jan 21.

Centre for Positron Emission Tomography, Austin Hospital, Heidelberg, Victoria, Australia.

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http://dx.doi.org/10.2967/jnumed.108.055756DOI Listing
February 2009

Evaluation of geometrical sensitivity for respiratory motion gating by GATE and NCAT simulation.

Conf Proc IEEE Eng Med Biol Soc 2007 ;2007:4165-8

School of Medical Sciences, RIMT, Australia.

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http://dx.doi.org/10.1109/IEMBS.2007.4353254DOI Listing
March 2008

Radiation dose to PET technologists and strategies to lower occupational exposure.

J Nucl Med Technol 2005 Mar;33(1):44-7

Department of Nuclear Medicine and Centre for PET, Austin Hospital, Melbourne, Australia.

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http://tech.snmjournals.org/content/33/1/44.full.pdf
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March 2005