Graeme J Alexander

Graeme J Alexander

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Graeme J Alexander

Graeme J Alexander

Publications by authors named "Graeme J Alexander"

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Pruritus Is Common and Undertreated in Patients With Primary Biliary Cholangitis in the United Kingdom.

Clin Gastroenterol Hepatol 2019 Jun 14;17(7):1379-1387.e3. Epub 2018 Dec 14.

Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom; National Institute for Health Research Newcastle Biomedical Research Centre, Newcastle University, Newcastle upon Tyne, United Kingdom.

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http://dx.doi.org/10.1016/j.cgh.2018.12.007DOI Listing
June 2019

Telomere, telomerase and liver disease.

Liver Int 2018 01;38(1):33-34

UCL Institute for Liver and Digestive Health, The Royal Free Trust, London, UK.

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http://dx.doi.org/10.1111/liv.13630DOI Listing
January 2018

Senescence in chronic liver disease: Is the future in aging?

J Hepatol 2016 10 28;65(4):825-834. Epub 2016 May 28.

UCL Institute for Liver and Digestive Health, The Royal Free Trust, London, UK; Department of Medicine, University of Cambridge, Cambridge, UK. Electronic address:

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http://dx.doi.org/10.1016/j.jhep.2016.05.030DOI Listing
October 2016

Persistence of Hepatitis C Virus Traces after Spontaneous Resolution of Hepatitis C.

PLoS One 2015 16;10(10):e0140312. Epub 2015 Oct 16.

Molecular Virology and Hepatology Research Group, Faculty of Medicine, Memorial University, St. John's, Newfoundland and Labrador, Canada.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0140312PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4608821PMC
June 2016

Magnetic resonance elastography in the detection of hepatorenal syndrome in patients with cirrhosis and ascites.

Eur Radiol 2015 Oct 23;25(10):2851-8. Epub 2015 Apr 23.

Department of Radiology, Addenbrooke's Hospital, Cambridge University Hospitals NHS Foundation Trust Hospital, England, UK,

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http://dx.doi.org/10.1007/s00330-015-3723-2DOI Listing
October 2015

Hepatocyte senescence explains conjugated bilirubinaemia in chronic liver failure.

J Hepatol 2015 Aug 1;63(2):532-3. Epub 2015 Apr 1.

Department of Medicine, University of Cambridge, Box 156, Cambridge University Hospitals NHS Trust, Hills Road, Cambridge CB2 0QQ, UK. Electronic address:

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http://dx.doi.org/10.1016/j.jhep.2015.03.031DOI Listing
August 2015

Selective insulin resistance in hepatocyte senescence.

Exp Cell Res 2015 Feb 28;331(1):38-45. Epub 2014 Sep 28.

Division of Gastroenterology and Hepatology, Department of Medicine, University of Cambridge, Cambridge, UK. Electronic address:

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http://dx.doi.org/10.1016/j.yexcr.2014.09.025DOI Listing
February 2015

The senescent hepatocyte gene signature in chronic liver disease.

Exp Gerontol 2014 Dec 18;60:37-45. Epub 2014 Sep 18.

Division of Gastroenterology & Hepatology, Department of Medicine, University of Cambridge, Cambridge, UK. Electronic address:

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http://dx.doi.org/10.1016/j.exger.2014.09.011DOI Listing
December 2014

Rifaximin is largely safe and well tolerated but caution is necessary when taken with statins.

Clin Gastroenterol Hepatol 2014 Oct 1;12(10):1765. Epub 2014 Apr 1.

Department of Hepatology, Cambridge University Hospital NHS Foundation Trust, Cambridge, United Kingdom.

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http://dx.doi.org/10.1016/j.cgh.2014.03.027DOI Listing
October 2014

Age-related macular degeneration and modification of systemic complement factor H production through liver transplantation.

Ophthalmology 2013 Aug 4;120(8):1612-8. Epub 2013 Apr 4.

Clinical and Experimental Sciences, Clinical Neurosciences, Faculty of Medicine, University of Southampton, Southampton, UK.

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http://dx.doi.org/10.1016/j.ophtha.2013.01.004DOI Listing
August 2013

γ-H2AX+CD8+ T lymphocytes cannot respond to IFN-α, IL-2 or IL-6 in chronic hepatitis C virus infection.

J Hepatol 2013 May 17;58(5):868-74. Epub 2012 Dec 17.

Department of Medicine, School of Clinical Medicine, University of Cambridge, Cambridge, UK.

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http://dx.doi.org/10.1016/j.jhep.2012.12.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3625113PMC
May 2013

Induced pluripotent stem cells: from Nobel Prizes to clinical applications.

J Hepatol 2013 Mar 3;58(3):625-9. Epub 2012 Nov 3.

Division of Gastroenterology and Hepatology, Department of Medicine, Cambridge University Hospitals NHS Foundation Trust, Cambridge CB2 0SZ, UK.

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http://dx.doi.org/10.1016/j.jhep.2012.10.026DOI Listing
March 2013

Sex and age are determinants of the clinical phenotype of primary biliary cirrhosis and response to ursodeoxycholic acid.

Gastroenterology 2013 Mar 12;144(3):560-569.e7; quiz e13-4. Epub 2012 Dec 12.

Division of Gastroenterology and Hepatology, Department of Medicine, University of Cambridge, Cambridge, United Kingdom.

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http://dx.doi.org/10.1053/j.gastro.2012.12.005DOI Listing
March 2013

Prevalence and risk factors for liver involvement in individuals with PiZZ-related lung disease.

Am J Respir Crit Care Med 2013 Mar 21;187(5):502-8. Epub 2012 Dec 21.

Liver Unit, Box 210, Addenbrooke's Hospital, Hills Road, Cambridge CB2 0QQ, UK.

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http://dx.doi.org/10.1164/rccm.201204-0739OCDOI Listing
March 2013

Comparison of endothelin receptors in normal versus cirrhotic human liver and in the liver from endothelial cell-specific ETB knockout mice.

Life Sci 2012 Oct 18;91(13-14):716-22. Epub 2012 Feb 18.

Clinical Pharmacology Unit, Box 110 Addenbrooke's Hospital, Cambridge CB2 0QQ, United Kingdom.

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http://dx.doi.org/10.1016/j.lfs.2012.02.003DOI Listing
October 2012

Sustained telomere length in hepatocytes and cholangiocytes with increasing age in normal liver.

Hepatology 2012 Oct 27;56(4):1510-20. Epub 2012 Aug 27.

Division of Gastroenterology & Hepatology, University Department of Medicine, Cambridge University Hospitals NHS Foundation Trust, Cambridge, United Kingdom.

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http://dx.doi.org/10.1002/hep.25787DOI Listing
October 2012

A comprehensive HBV array for the detection of HBV mutants and genotype.

Clin Biochem 2011 Oct 6;44(14-15):1253-60. Epub 2011 Aug 6.

Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong.

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http://dx.doi.org/10.1016/j.clinbiochem.2011.07.014DOI Listing
October 2011

Renal failure in chronic liver disease and the hepatorenal syndrome.

Br J Hosp Med (Lond) 2011 Sep;72(9):497-503

Department of Hepatology, Addenbrooke's Hospital, Cambridge, UK.

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September 2011

Switching to sirolimus-based immune suppression after liver transplantation is safe and effective: a single-center experience.

Transplantation 2011 Jan;91(1):128-32

Department of Surgery, University of Cambridge, Addenbrooke’s Hospital, Cambridge, United Kingdom.

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http://dx.doi.org/10.1097/tp.0b013e3181fe131bDOI Listing
January 2011

A novel monoclonal antibody to characterize pathogenic polymers in liver disease associated with alpha1-antitrypsin deficiency.

Hepatology 2010 Sep;52(3):1078-88

Department of Medicine, University of Cambridge, Cambridge Institute for Medical Research, Wellcome Trust/Medical Research Council Building, Cambridge, UK.

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http://dx.doi.org/10.1002/hep.23760DOI Listing
September 2010

Hepatocellular carcinoma in patients with chronic hepatitis C virus infection without cirrhosis.

World J Gastroenterol 2010 Aug;16(32):4061-5

Department of Hepatology, Southampton General Hospital, Tremona Road, Southampton, Hampshire, United Kingdom.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2928460PMC
http://dx.doi.org/10.3748/wjg.v16.i32.4061DOI Listing
August 2010

Features of immune senescence in liver transplant recipients with established grafts.

Liver Transpl 2010 May;16(5):577-87

Department of Medicine, University of Cambridge, Cambridge, UK.

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http://dx.doi.org/10.1002/lt.22033DOI Listing
May 2010

Heterogeneous inflammatory changes in liver graft recipients with normal biochemistry.

Transplantation 2010 Mar;89(6):739-48

Department of Medicine, University of Cambridge, Cambridge, United Kingdom.

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http://dx.doi.org/10.1097/TP.0b013e3181c96b32DOI Listing
March 2010

Tumor recurrence following liver transplantation for hepatocellular carcinoma: role of tumor proliferation status.

Liver Transpl 2010 Mar;16(3):279-88

University of Cambridge Department of Medicine, Addenbrooke's Hospital, Hills Road, Cambridge, United Kingdom CB2 2QQ.

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http://dx.doi.org/10.1002/lt.21993DOI Listing
March 2010

Emphysematous gastritis in a liver transplant recipient.

Liver Transpl 2010 Jan;16(1):104-5

Liver Transplant Unit, Addenbrooke's Hospital, Cambridge University Hospitals National Health Service Foundation Trust, Cambridge, United Kingdom.

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http://dx.doi.org/10.1002/lt.21986DOI Listing
January 2010

Pulmonary complications in liver disease.

Br J Hosp Med (Lond) 2009 Dec;70(12):685-91

Department of Hepatology, Cambridge University Hospitals NHS Foundation Trust, Cambridge CB2 0QQ.

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http://dx.doi.org/10.12968/hmed.2009.70.12.45504DOI Listing
December 2009

A real-time Taqman method for hepatitis C virus genotyping and methods for further subtyping of isolates.

Methods Mol Biol 2009 ;510:55-71

Health Protection Agency Cambridge Microbiology and Public Health Laboratory Addenbrooke's Hospital, Cambridge, UK.

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http://dx.doi.org/10.1007/978-1-59745-394-3_5DOI Listing
March 2009

Minichromosome maintenance protein-2-positive portal tract lymphocytes distinguish acute cellular rejection from hepatitis C virus recurrence after liver transplantation.

Liver Transpl 2009 Mar;15(3):306-12

Department of Medicine, School of Clinical Medicine, University of Cambridge, Cambridge, United Kingdom.

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http://dx.doi.org/10.1002/lt.21680DOI Listing
March 2009

Complement abnormalities in acquired lipodystrophy revisited.

J Clin Endocrinol Metab 2009 Jan 14;94(1):10-6. Epub 2008 Oct 14.

Metabolic Research Laboratories, Institute of Metabolic Science, University of Cambridge, Addenbrooke's Hospital, Hills Road, Cambridge CB2 0QQ, United Kingdom.

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http://dx.doi.org/10.1210/jc.2008-1703DOI Listing
January 2009

The case for combination antiviral therapy for chronic hepatitis B virus infection.

Lancet Infect Dis 2008 Jul 14;8(7):444-8. Epub 2008 May 14.

Department of Hepatology, University Department of Medicine, Addenbrooke's Hospital, Cambridge, UK.

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http://dx.doi.org/10.1016/S1473-3099(08)70102-6DOI Listing
July 2008

A single centre experience of liver disease in adults with cystic fibrosis 1995-2006.

J Cyst Fibros 2008 May 26;7(3):252-7. Epub 2007 Nov 26.

Department of Medicine, University of Cambridge, Addenbrooke's Hospital, Hills Road, Cambridge, USA.

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http://dx.doi.org/10.1016/j.jcf.2007.10.004DOI Listing
May 2008

Event-biased referral can distort estimation of hepatitis C virus progression rate to cirrhosis, and of prognostic influences.

J Clin Epidemiol 2007 Nov 16;60(11):1140-8. Epub 2007 Jul 16.

MRC Biostatistics Unit, Robinson Way, Institute of Public Health, University Forvie Site Robinson Way, Cambridge, Cambridgeshire, UK.

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http://dx.doi.org/10.1016/j.jclinepi.2007.01.015DOI Listing
November 2007

T-regulatory lymphocytes and chronic viral hepatitis.

Expert Opin Biol Ther 2007 Nov;7(11):1689-703

University of Cambridge School of Clinical Medicine, Department of Medicine, Box 157, Addenbrooke's Hospital, Hills Road, Cambridge, CB2 2QQ, UK.

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http://dx.doi.org/10.1517/14712598.7.11.1689 DOI Listing
November 2007

Tumour lymphocytic infiltrate and recurrence of hepatocellular carcinoma following liver transplantation.

J Hepatol 2006 Aug 28;45(2):246-53. Epub 2006 Feb 28.

Department of Medicine, University of Cambridge School of Clinical Medicine, Addenbrooke's NHS Trust, Hills Road, Cambridge CB2 2QQ, UK.

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http://dx.doi.org/10.1016/j.jhep.2005.12.027DOI Listing
August 2006

Early recurrence of neurocysticercosis after orthotopic liver transplant.

Liver Transpl 2006 Mar;12(3):490-1

Department of Hepatology, Addenbrooke's Hospital, Cambridge, United Kingdom.

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http://dx.doi.org/10.1002/lt.20643DOI Listing
March 2006

Hepatic and intestinal schistosomiasis after orthotopic liver transplant.

Liver Transpl 2005 Dec;11(12):1603-7

Department of Hepatology, Addenbrooke's Hospital, Cambridge CB2 2QQ, UK.

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http://dx.doi.org/10.1002/lt.20622DOI Listing
December 2005

Reactivation of herpes simplex virus after liver transplantation.

Transplantation 2005 Nov;80(9):1353-4

Department of Hepatology, Addenbrooke's Hospital, Cambridge, UK.

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http://dx.doi.org/10.1097/01.tp.0000179113.34334.fcDOI Listing
November 2005

A real-time Taqman method for hepatitis C virus genotyping.

J Clin Virol 2005 Oct;34(2):115-21

Health Protection Agency, East of England Laboratory, Addenbrookes Hospital, Cambridge CB2 2QW, UK.

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http://dx.doi.org/10.1016/j.jcv.2005.02.011DOI Listing
October 2005

Regulatory T cells suppress in vitro proliferation of virus-specific CD8+ T cells during persistent hepatitis C virus infection.

J Virol 2005 Jun;79(12):7852-9

Peter Medawar Building for Pathogen Research, Nuffield Department of Clinical Medicine, University of Oxford, South Parks Road, Oxford OX1 3SY, United Kingdom.

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http://jvi.asm.org/cgi/doi/10.1128/JVI.79.12.7852-7859.2005
Publisher Site
http://dx.doi.org/10.1128/JVI.79.12.7852-7859.2005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1143649PMC
June 2005

Ma huang associated acute liver failure requiring liver transplantation.

Eur J Gastroenterol Hepatol 2005 May;17(5):581-4

Addenbrooke's Hospital, Cambridge, UK.

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http://dx.doi.org/10.1097/00042737-200505000-00017DOI Listing
May 2005

Compromised lymphocytes infiltrate hepatocellular carcinoma: the role of T-regulatory cells.

Hepatology 2005 Apr;41(4):722-30

Department of Medicine, University of Cambridge School of Clinical Medicine, Addenbrooke's NHS Trust, Cambridge CB2 2QQ, UK.

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http://dx.doi.org/10.1002/hep.20644DOI Listing
April 2005

Mechanisms of hypertension after liver transplantation.

Transplantation 2005 Apr;79(8):935-40

University Department of Medicine, Addenbrooke's Hospital, Cambridge CB2 2QQ, England, UK.

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http://dx.doi.org/10.1097/01.tp.0000158738.00927.65DOI Listing
April 2005

Bell's palsy associated with IFN-alpha and ribavirin therapy for hepatitis C virus infection.

J Interferon Cytokine Res 2005 Mar;25(3):174-6

Department of Hepatology, Addenbrooke's Hospital, Cambridge, CB2 2QQ, UK.

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http://dx.doi.org/10.1089/jir.2005.25.174DOI Listing
March 2005

Hepatocyte-specific gene expression from integrated lentiviral vectors.

J Gene Med 2004 Sep;6(9):974-83

Department of Medicine, University of Cambridge, Addenbrooke's Hospital, Hills Road, Cambridge CB2 2QQ, UK.

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http://dx.doi.org/10.1002/jgm.591DOI Listing
September 2004

Hemodynamic effects of amlodipine, bisoprolol, and lisinopril in hypertensive patients after liver transplantation.

Transplantation 2004 Mar;77(5):748-50

Department of Medicine, Addenbrooke's Hospital, Cambridge, United Kingdom.

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http://dx.doi.org/10.1097/01.tp.0000116418.78963.dcDOI Listing
March 2004

Is there disparity between risk and incidence of cardiovascular disease after liver transplant?

Transplantation 2004 Jan;77(1):93-9

Department of Medicine, University of Cambridge, School of Clinical Medicine, Addenbrooke's Hospital, Cambridge, UK.

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http://dx.doi.org/10.1097/01.TP.0000100685.70064.90DOI Listing
January 2004

Sirolimus inhibits oxidative burst activity in transplant recipients.

Transplantation 2003 Dec;76(12):1766-8

Department of Medicine, University of Cambridge School of Clinical Medicine, Addenbrooke's Hospital, Hills Road, Cambridge CB2 2QQ, United Kingdom.

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http://dx.doi.org/10.1097/01.TP.0000093995.08240.49DOI Listing
December 2003

Liver fatty acid-binding protein as a sensitive serum marker of acute hepatocellular damage in liver transplant recipients.

Clin Chem 2002 Nov;48(11):2055-7

Department of Physiology, Maastricht University, PO Box 616, 6200 MD Maastricht, The Netherlands.

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November 2002

Lack of effect of intravenous pamidronate on fracture incidence and bone mineral density after orthotopic liver transplantation.

J Hepatol 2002 Jul;37(1):93-100

Department of Medicine, University of Cambridge School of Clinical Medicine, Addenbrooke's Hospital, Hills Road, Cambridge CB2 2QQ, UK.

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http://dx.doi.org/10.1016/s0168-8278(02)00100-9DOI Listing
July 2002

Effects of a single infusion of pamidronate prior to liver transplantation: a bone histomorphometric study.

Transpl Int 2002 Jun 16;15(6):290-5. Epub 2002 Apr 16.

Department of Medicine, Box 157, Addenbrooke's Hospital, University of Cambridge School of Clinical Medicine, Cambridge CB2 2QQ, UK.

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http://dx.doi.org/10.1007/s00147-002-0402-4DOI Listing
June 2002