Graeme Alexander

Graeme Alexander

UNVERIFIED PROFILE

Are you Graeme Alexander?   Register this Author

Register author
Graeme Alexander

Graeme Alexander

Publications by authors named "Graeme Alexander"

Are you Graeme Alexander?   Register this Author

100Publications

2473Reads

23Profile Views

Pruritus Is Common and Undertreated in Patients With Primary Biliary Cholangitis in the United Kingdom.

Clin Gastroenterol Hepatol 2019 Jun 14;17(7):1379-1387.e3. Epub 2018 Dec 14.

Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom; National Institute for Health Research Newcastle Biomedical Research Centre, Newcastle University, Newcastle upon Tyne, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.cgh.2018.12.007DOI Listing
June 2019

Is the conquest of Hepatitis C imminent?

Expert Rev Mol Med 2019 03 26;21:e3. Epub 2019 Mar 26.

Institute for Liver and Digestive Health,University College London,London,UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1017/erm.2019.3DOI Listing
March 2019

Genetic association analysis identifies variants associated with disease progression in primary sclerosing cholangitis.

Gut 2018 08 4;67(8):1517-1524. Epub 2017 Aug 4.

Department of Gastroenterology and Hepatology, University of Groningen and University Medical Centre Groningen, Groningen, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/gutjnl-2016-313598DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5797498PMC
August 2018

Telomere, telomerase and liver disease.

Liver Int 2018 01;38(1):33-34

UCL Institute for Liver and Digestive Health, The Royal Free Trust, London, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/liv.13630DOI Listing
January 2018

Association between progressive hepatic morphology changes on serial MR imaging and clinical outcome in primary sclerosing cholangitis.

J Med Imaging Radiat Oncol 2017 Oct 22;61(5):636-642. Epub 2017 Apr 22.

Department of Radiology, Cambridge University Hospitals NHS Foundation Trust, Addenbrooke's Hospital, Cambridge, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/1754-9485.12610DOI Listing
October 2017

Is elimination of hepatitis C from the UK by 2030 a realistic goal?

Br Med Bull 2017 09;123(1):59-67

Cambridge University Hospitals NHS Foundation Trust, Hill's Road, Cambridge, CB2 0QQ, UK.

View Article

Download full-text PDF

Source
http://academic.oup.com/bmb/article/123/1/59/3865512/Is-elim
Publisher Site
http://dx.doi.org/10.1093/bmb/ldx017DOI Listing
September 2017

Genome-wide association study of primary sclerosing cholangitis identifies new risk loci and quantifies the genetic relationship with inflammatory bowel disease.

Nat Genet 2017 Feb 19;49(2):269-273. Epub 2016 Dec 19.

Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/ng.3745DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5540332PMC
February 2017

Senescence in chronic liver disease: Is the future in aging?

J Hepatol 2016 10 28;65(4):825-834. Epub 2016 May 28.

UCL Institute for Liver and Digestive Health, The Royal Free Trust, London, UK; Department of Medicine, University of Cambridge, Cambridge, UK. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jhep.2016.05.030DOI Listing
October 2016

Persistence of Hepatitis C Virus Traces after Spontaneous Resolution of Hepatitis C.

PLoS One 2015 16;10(10):e0140312. Epub 2015 Oct 16.

Molecular Virology and Hepatology Research Group, Faculty of Medicine, Memorial University, St. John's, Newfoundland and Labrador, Canada.

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0140312PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4608821PMC
June 2016

Renal impairment in cirrhosis unrelated to hepatorenal syndrome.

Can J Gastroenterol Hepatol 2015 Jun-Jul;29(5):253-7. Epub 2015 Apr 15.

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4467485PMC
http://dx.doi.org/10.1155/2015/967683DOI Listing
March 2016

Magnetic resonance elastography in the detection of hepatorenal syndrome in patients with cirrhosis and ascites.

Eur Radiol 2015 Oct 23;25(10):2851-8. Epub 2015 Apr 23.

Department of Radiology, Addenbrooke's Hospital, Cambridge University Hospitals NHS Foundation Trust Hospital, England, UK,

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00330-015-3723-2DOI Listing
October 2015

Hepatocyte senescence explains conjugated bilirubinaemia in chronic liver failure.

J Hepatol 2015 Aug 1;63(2):532-3. Epub 2015 Apr 1.

Department of Medicine, University of Cambridge, Box 156, Cambridge University Hospitals NHS Trust, Hills Road, Cambridge CB2 0QQ, UK. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jhep.2015.03.031DOI Listing
August 2015

Selective insulin resistance in hepatocyte senescence.

Exp Cell Res 2015 Feb 28;331(1):38-45. Epub 2014 Sep 28.

Division of Gastroenterology and Hepatology, Department of Medicine, University of Cambridge, Cambridge, UK. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.yexcr.2014.09.025DOI Listing
February 2015

The senescent hepatocyte gene signature in chronic liver disease.

Exp Gerontol 2014 Dec 18;60:37-45. Epub 2014 Sep 18.

Division of Gastroenterology & Hepatology, Department of Medicine, University of Cambridge, Cambridge, UK. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.exger.2014.09.011DOI Listing
December 2014

Rifaximin is largely safe and well tolerated but caution is necessary when taken with statins.

Clin Gastroenterol Hepatol 2014 Oct 1;12(10):1765. Epub 2014 Apr 1.

Department of Hepatology, Cambridge University Hospital NHS Foundation Trust, Cambridge, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.cgh.2014.03.027DOI Listing
October 2014

Global gene expression profiling reveals SPINK1 as a potential hepatocellular carcinoma marker.

PLoS One 2013 18;8(3):e59459. Epub 2013 Mar 18.

Cancer Research UK Cambridge Research Institute, Li Ka Shing Centre, Cambridge, United Kingdom.

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0059459PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3601070PMC
September 2013

Age-related macular degeneration and modification of systemic complement factor H production through liver transplantation.

Ophthalmology 2013 Aug 4;120(8):1612-8. Epub 2013 Apr 4.

Clinical and Experimental Sciences, Clinical Neurosciences, Faculty of Medicine, University of Southampton, Southampton, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ophtha.2013.01.004DOI Listing
August 2013

Dense genotyping of immune-related disease regions identifies nine new risk loci for primary sclerosing cholangitis.

Nat Genet 2013 Jun 21;45(6):670-5. Epub 2013 Apr 21.

Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK.

View Article

Download full-text PDF

Source
http://petercroucher.com/wp-content/uploads/2013/10/51_Natur
Web Search
http://www.nature.com/doifinder/10.1038/ng.2616
Publisher Site
http://dx.doi.org/10.1038/ng.2616DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3667736PMC
June 2013

γ-H2AX+CD8+ T lymphocytes cannot respond to IFN-α, IL-2 or IL-6 in chronic hepatitis C virus infection.

J Hepatol 2013 May 17;58(5):868-74. Epub 2012 Dec 17.

Department of Medicine, School of Clinical Medicine, University of Cambridge, Cambridge, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jhep.2012.12.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3625113PMC
May 2013

Induced pluripotent stem cells: from Nobel Prizes to clinical applications.

J Hepatol 2013 Mar 3;58(3):625-9. Epub 2012 Nov 3.

Division of Gastroenterology and Hepatology, Department of Medicine, Cambridge University Hospitals NHS Foundation Trust, Cambridge CB2 0SZ, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jhep.2012.10.026DOI Listing
March 2013

Hepatocyte senescence predicts progression in non-alcohol-related fatty liver disease.

J Hepatol 2013 Mar 8;58(3):549-56. Epub 2012 Nov 8.

Division of Gastroenterology and Hepatology, Department of Medicine, University of Cambridge, Cambridge CB2 0QQ, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jhep.2012.10.031DOI Listing
March 2013

Sex and age are determinants of the clinical phenotype of primary biliary cirrhosis and response to ursodeoxycholic acid.

Gastroenterology 2013 Mar 12;144(3):560-569.e7; quiz e13-4. Epub 2012 Dec 12.

Division of Gastroenterology and Hepatology, Department of Medicine, University of Cambridge, Cambridge, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1053/j.gastro.2012.12.005DOI Listing
March 2013

Prevalence and risk factors for liver involvement in individuals with PiZZ-related lung disease.

Am J Respir Crit Care Med 2013 Mar 21;187(5):502-8. Epub 2012 Dec 21.

Liver Unit, Box 210, Addenbrooke's Hospital, Hills Road, Cambridge CB2 0QQ, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1164/rccm.201204-0739OCDOI Listing
March 2013

Comparison of endothelin receptors in normal versus cirrhotic human liver and in the liver from endothelial cell-specific ETB knockout mice.

Life Sci 2012 Oct 18;91(13-14):716-22. Epub 2012 Feb 18.

Clinical Pharmacology Unit, Box 110 Addenbrooke's Hospital, Cambridge CB2 0QQ, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.lfs.2012.02.003DOI Listing
October 2012

Sustained telomere length in hepatocytes and cholangiocytes with increasing age in normal liver.

Hepatology 2012 Oct 27;56(4):1510-20. Epub 2012 Aug 27.

Division of Gastroenterology & Hepatology, University Department of Medicine, Cambridge University Hospitals NHS Foundation Trust, Cambridge, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/hep.25787DOI Listing
October 2012

Vacuolation in hepatocyte nuclei is a marker of senescence.

J Clin Pathol 2012 Jun 23;65(6):557-60. Epub 2012 Mar 23.

Division of Gastroenterology & Hepatology, University Department of Medicine, Cambridge University Hospitals, Cambridge, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/jclinpath-2011-200641DOI Listing
June 2012

Vascular invasion leaves its mark in hepatocellular carcinoma.

J Hepatol 2011 Dec 20;55(6):1174-5. Epub 2011 May 20.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jhep.2011.05.005DOI Listing
December 2011

A comprehensive HBV array for the detection of HBV mutants and genotype.

Clin Biochem 2011 Oct 6;44(14-15):1253-60. Epub 2011 Aug 6.

Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.clinbiochem.2011.07.014DOI Listing
October 2011

Renal failure in chronic liver disease and the hepatorenal syndrome.

Br J Hosp Med (Lond) 2011 Sep;72(9):497-503

Department of Hepatology, Addenbrooke's Hospital, Cambridge, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.12968/hmed.2011.72.9.497DOI Listing
September 2011

The pattern of late mortality in liver transplant recipients in the United Kingdom.

Transplantation 2011 Jun;91(11):1240-4

Department of Medicine, University of Cambridge, Cambridge, United Kingdom.

View Article

Download full-text PDF

Source
https://insights.ovid.com/crossref?an=00007890-201106150-000
Publisher Site
http://dx.doi.org/10.1097/TP.0b013e31821841baDOI Listing
June 2011

Switching to sirolimus-based immune suppression after liver transplantation is safe and effective: a single-center experience.

Transplantation 2011 Jan;91(1):128-32

Department of Surgery, University of Cambridge, Addenbrooke’s Hospital, Cambridge, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/tp.0b013e3181fe131bDOI Listing
January 2011

Ageing, telomeres, senescence, and liver injury.

J Hepatol 2010 Nov 24;53(5):950-61. Epub 2010 Jul 24.

Department of Medicine, University of Cambridge, Cambridge, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jhep.2010.06.009DOI Listing
November 2010

A novel monoclonal antibody to characterize pathogenic polymers in liver disease associated with alpha1-antitrypsin deficiency.

Hepatology 2010 Sep;52(3):1078-88

Department of Medicine, University of Cambridge, Cambridge Institute for Medical Research, Wellcome Trust/Medical Research Council Building, Cambridge, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/hep.23760DOI Listing
September 2010

Enhanced liver fibrosis test can predict clinical outcomes in patients with chronic liver disease.

Gut 2010 Sep 30;59(9):1245-51. Epub 2010 Jul 30.

Public Health Sciences and Medical Statistics (MP805) South Academic Block Southampton General Hospital, Southampton SO53 1ER, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/gut.2009.203166DOI Listing
September 2010

Hepatocellular carcinoma in patients with chronic hepatitis C virus infection without cirrhosis.

World J Gastroenterol 2010 Aug;16(32):4061-5

Department of Hepatology, Southampton General Hospital, Tremona Road, Southampton, Hampshire, United Kingdom.

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2928460PMC
http://dx.doi.org/10.3748/wjg.v16.i32.4061DOI Listing
August 2010

Features of immune senescence in liver transplant recipients with established grafts.

Liver Transpl 2010 May;16(5):577-87

Department of Medicine, University of Cambridge, Cambridge, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/lt.22033DOI Listing
May 2010

Heterogeneous inflammatory changes in liver graft recipients with normal biochemistry.

Transplantation 2010 Mar;89(6):739-48

Department of Medicine, University of Cambridge, Cambridge, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/TP.0b013e3181c96b32DOI Listing
March 2010

Tumor recurrence following liver transplantation for hepatocellular carcinoma: role of tumor proliferation status.

Liver Transpl 2010 Mar;16(3):279-88

University of Cambridge Department of Medicine, Addenbrooke's Hospital, Hills Road, Cambridge, United Kingdom CB2 2QQ.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/lt.21993DOI Listing
March 2010

Emphysematous gastritis in a liver transplant recipient.

Liver Transpl 2010 Jan;16(1):104-5

Liver Transplant Unit, Addenbrooke's Hospital, Cambridge University Hospitals National Health Service Foundation Trust, Cambridge, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/lt.21986DOI Listing
January 2010

Pulmonary complications in liver disease.

Br J Hosp Med (Lond) 2009 Dec;70(12):685-91

Department of Hepatology, Cambridge University Hospitals NHS Foundation Trust, Cambridge CB2 0QQ.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.12968/hmed.2009.70.12.45504DOI Listing
December 2009

A real-time Taqman method for hepatitis C virus genotyping and methods for further subtyping of isolates.

Methods Mol Biol 2009 ;510:55-71

Health Protection Agency Cambridge Microbiology and Public Health Laboratory Addenbrooke's Hospital, Cambridge, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/978-1-59745-394-3_5DOI Listing
March 2009

Minichromosome maintenance protein-2-positive portal tract lymphocytes distinguish acute cellular rejection from hepatitis C virus recurrence after liver transplantation.

Liver Transpl 2009 Mar;15(3):306-12

Department of Medicine, School of Clinical Medicine, University of Cambridge, Cambridge, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/lt.21680DOI Listing
March 2009

Liver transplantation for liver disease caused by hepatitis C virus infection.

Br J Hosp Med (Lond) 2009 Feb;70(2):95-100

Department of Hepatology, Addenbrooke's Hospital, Cambridge.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.12968/hmed.2009.70.2.38908DOI Listing
February 2009

Complement abnormalities in acquired lipodystrophy revisited.

J Clin Endocrinol Metab 2009 Jan 14;94(1):10-6. Epub 2008 Oct 14.

Metabolic Research Laboratories, Institute of Metabolic Science, University of Cambridge, Addenbrooke's Hospital, Hills Road, Cambridge CB2 0QQ, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1210/jc.2008-1703DOI Listing
January 2009

Altered expression of cell cycle and apoptotic proteins in chronic hepatitis C virus infection.

BMC Microbiol 2008 Aug 5;8:133. Epub 2008 Aug 5.

1Department of Biological and Biomedical Sciences, Aga Khan University, Karachi, Pakistan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/1471-2180-8-133DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2518161PMC
August 2008

The case for combination antiviral therapy for chronic hepatitis B virus infection.

Lancet Infect Dis 2008 Jul 14;8(7):444-8. Epub 2008 May 14.

Department of Hepatology, University Department of Medicine, Addenbrooke's Hospital, Cambridge, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/S1473-3099(08)70102-6DOI Listing
July 2008

A single centre experience of liver disease in adults with cystic fibrosis 1995-2006.

J Cyst Fibros 2008 May 26;7(3):252-7. Epub 2007 Nov 26.

Department of Medicine, University of Cambridge, Addenbrooke's Hospital, Hills Road, Cambridge, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jcf.2007.10.004DOI Listing
May 2008

Event-biased referral can distort estimation of hepatitis C virus progression rate to cirrhosis, and of prognostic influences.

J Clin Epidemiol 2007 Nov 16;60(11):1140-8. Epub 2007 Jul 16.

MRC Biostatistics Unit, Robinson Way, Institute of Public Health, University Forvie Site Robinson Way, Cambridge, Cambridgeshire, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jclinepi.2007.01.015DOI Listing
November 2007

T-regulatory lymphocytes and chronic viral hepatitis.

Expert Opin Biol Ther 2007 Nov;7(11):1689-703

University of Cambridge School of Clinical Medicine, Department of Medicine, Box 157, Addenbrooke's Hospital, Hills Road, Cambridge, CB2 2QQ, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1517/14712598.7.11.1689DOI Listing
November 2007

Tumour lymphocytic infiltrate and recurrence of hepatocellular carcinoma following liver transplantation.

J Hepatol 2006 Aug 28;45(2):246-53. Epub 2006 Feb 28.

Department of Medicine, University of Cambridge School of Clinical Medicine, Addenbrooke's NHS Trust, Hills Road, Cambridge CB2 2QQ, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jhep.2005.12.027DOI Listing
August 2006

Liver transplantation in an adult with sclerosing cholangitis due to Langerhans cell histiocytosis.

J Hepatol 2006 Apr 3;44(4):829-31. Epub 2006 Feb 3.

Department of Hepatology, Addenbrooke's Hospital, Box 210, Cambridge CB2 2QQ, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jhep.2005.12.024DOI Listing
April 2006

Early recurrence of neurocysticercosis after orthotopic liver transplant.

Liver Transpl 2006 Mar;12(3):490-1

Department of Hepatology, Addenbrooke's Hospital, Cambridge, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/lt.20643DOI Listing
March 2006

Hepatic and intestinal schistosomiasis after orthotopic liver transplant.

Liver Transpl 2005 Dec;11(12):1603-7

Department of Hepatology, Addenbrooke's Hospital, Cambridge CB2 2QQ, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/lt.20622DOI Listing
December 2005

Reactivation of herpes simplex virus after liver transplantation.

Transplantation 2005 Nov;80(9):1353-4

Department of Hepatology, Addenbrooke's Hospital, Cambridge, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/01.tp.0000179113.34334.fcDOI Listing
November 2005

A real-time Taqman method for hepatitis C virus genotyping.

J Clin Virol 2005 Oct;34(2):115-21

Health Protection Agency, East of England Laboratory, Addenbrookes Hospital, Cambridge CB2 2QW, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jcv.2005.02.011DOI Listing
October 2005

Regulatory T cells suppress in vitro proliferation of virus-specific CD8+ T cells during persistent hepatitis C virus infection.

J Virol 2005 Jun;79(12):7852-9

Peter Medawar Building for Pathogen Research, Nuffield Department of Clinical Medicine, University of Oxford, South Parks Road, Oxford OX1 3SY, United Kingdom.

View Article

Download full-text PDF

Source
http://jvi.asm.org/cgi/doi/10.1128/JVI.79.12.7852-7859.2005
Publisher Site
http://dx.doi.org/10.1128/JVI.79.12.7852-7859.2005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1143649PMC
June 2005

Mechanisms of hypertension after liver transplantation.

Transplantation 2005 Apr;79(8):935-40

University Department of Medicine, Addenbrooke's Hospital, Cambridge CB2 2QQ, England, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/01.tp.0000158738.00927.65DOI Listing
April 2005