Gosse J Adema

Gosse J Adema

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Gosse J Adema

Publications by authors named "Gosse J Adema"

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DC-SCRIPT deficiency delays mouse mammary gland development and branching morphogenesis.

Dev Biol 2019 Nov 29;455(1):42-50. Epub 2019 Jun 29.

Radiotherapy & OncoImmunology Laboratory, Department of Radiation Oncology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, 6525 GA, Nijmegen, the Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.ydbio.2019.06.023DOI Listing
November 2019

Immunotherapy and the Interventional Oncologist: Challenges and Opportunities-A Society of Interventional Oncology White Paper.

Radiology 2019 Jul 23;292(1):25-34. Epub 2019 Apr 23.

From the Interventional Radiology Service, Memorial Sloan Kettering Cancer Center, 1275 York Ave, H-118, New York, NY 10065 (J.P.E.); Department of Radiology and Imaging Sciences, University of Utah School of Medicine, Salt Lake City, Utah (G.C.F.); Department of Radiation Oncology, Radboud University Medical Center, Nijmegen, the Netherlands (G.J.A., M.d.B.); Department of Radiology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Mass (M.A.); Division of Vascular and Interventional Radiology, Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, Conn (J.C.); Department of Radiodiagnostic and Interventional Radiology, University of Lausanne, Lausanne, Switzerland (R.D.); Penn Image-Guided Interventions Laboratory and Department of Radiology, Hospital of the University of Pennsylvania, Philadelphia, Pa (S.J.H.); Department of Radiology, University of Colorado, Denver, Colo (D.T.J.); Department of Radiology, Ludwig-Maximilian University, Munich, Germany (J.R.); Division of Vascular and Interventional Radiology, Stanford University, Stanford, Calif (D.Y.S.); Division of Interventional Radiology, Mayo Clinic Florida, Jacksonville, Fla (B.B.T.); Center for Interventional Oncology, National Cancer Institute, Radiology and Imaging Sciences, National Institutes of Health Clinical Center, Bethesda, Md (B.J.W.); Department of Radiology, Mayo Clinic, Rochester Minn (D.W.); and Department of Radiology, Hadassah Hebrew University Medical Center, Jerusalem, Israel (S.N.G.).

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http://dx.doi.org/10.1148/radiol.2019182326DOI Listing
July 2019

Sialic acid glycoengineering using N-acetylmannosamine and sialic acid analogs.

Glycobiology 2019 06;29(6):433-445

Radiotherapy & OncoImmunology Laboratory, Department of Radiation Oncology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Geert Grooteplein Zuid 32, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1093/glycob/cwz026DOI Listing
June 2019

Expression profiling of immune inhibitory Siglecs and their ligands in patients with glioma.

Cancer Immunol Immunother 2019 Jun 5;68(6):937-949. Epub 2019 Apr 5.

Radiotherapy and OncoImmunology Laboratory, Department of Radiation Oncology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Geert Grooteplein Zuid 32, 6525 GA, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1007/s00262-019-02332-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6529385PMC
June 2019

Interactions among myeloid regulatory cells in cancer.

Cancer Immunol Immunother 2019 Apr 12;68(4):645-660. Epub 2018 Jul 12.

Institute of Pulmonary Medicine, Hadassah-Hebrew University Medical Center, Jerusalem, Israel.

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http://dx.doi.org/10.1007/s00262-018-2200-6DOI Listing
April 2019

Deciphering myeloid-derived suppressor cells: isolation and markers in humans, mice and non-human primates.

Cancer Immunol Immunother 2019 Apr 25;68(4):687-697. Epub 2019 Jan 25.

Radiotherapy and OncoImmunology Laboratory, Department of Radiation Oncology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Geert Grooteplein 28, 6500 HB, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1007/s00262-019-02302-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6447515PMC
April 2019

Potent Metabolic Sialylation Inhibitors Based on C-5-Modified Fluorinated Sialic Acids.

J Med Chem 2019 01 31;62(2):1014-1021. Epub 2018 Dec 31.

Cluster for Molecular Chemistry, Institute for Molecules and Materials , Radboud University Nijmegen , Nijmegen 6525AJ , The Netherlands.

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http://dx.doi.org/10.1021/acs.jmedchem.8b01757DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348442PMC
January 2019

Adjuvants Enhancing Cross-Presentation by Dendritic Cells: The Key to More Effective Vaccines?

Front Immunol 2018 13;9:2874. Epub 2018 Dec 13.

Radiotherapy and OncoImmunology Laboratory, Department of Radiation Oncology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, Netherlands.

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https://www.frontiersin.org/article/10.3389/fimmu.2018.02874
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http://dx.doi.org/10.3389/fimmu.2018.02874DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6300500PMC
December 2018

Selective Inhibition of Sialic Acid-Based Molecular Mimicry in Haemophilus influenzae Abrogates Serum Resistance.

Cell Chem Biol 2018 10 5;25(10):1279-1285.e8. Epub 2018 Jul 5.

Cluster of Molecular Chemistry, Institute for Molecules and Materials, Radboud University, Nijmegen 6525 AJ, the Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.chembiol.2018.05.018DOI Listing
October 2018

Sialic Acid Blockade Suppresses Tumor Growth by Enhancing T-cell-Mediated Tumor Immunity.

Cancer Res 2018 07 27;78(13):3574-3588. Epub 2018 Apr 27.

Radiotherapy & OncoImmunology Laboratory, Department of Radiation Oncology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, the Netherlands.

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http://cancerres.aacrjournals.org/lookup/doi/10.1158/0008-54
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http://dx.doi.org/10.1158/0008-5472.CAN-17-3376DOI Listing
July 2018

Dendritic Cells Actively Limit Interleukin-10 Production Under Inflammatory Conditions DC-SCRIPT and Dual-Specificity Phosphatase 4.

Front Immunol 2018 22;9:1420. Epub 2018 Jun 22.

Radiotherapy & OncoImmunology Laboratory, Department of Radiation Oncology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, Netherlands.

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http://dx.doi.org/10.3389/fimmu.2018.01420DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6023963PMC
June 2018

Lipid Droplets as Immune Modulators in Myeloid Cells.

Trends Immunol 2018 05 22;39(5):380-392. Epub 2018 Feb 22.

Department of Radiation Oncology, Radiotherapy & OncoImmunology Laboratory, Radboud Institute for Molecular Life Sciences, Radboud UMC, Geert Grooteplein Zuid 32, 6525 GA, Nijmegen, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.it.2018.01.012DOI Listing
May 2018

Cellular metabolism of tumor-associated macrophages - functional impact and consequences.

FEBS Lett 2017 10 11;591(19):3022-3041. Epub 2017 Aug 11.

Department of Internal Medicine, Radboud University Medical Center, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1002/1873-3468.12771DOI Listing
October 2017

Impact of MR-guided boiling histotripsy in distinct murine tumor models.

Ultrason Sonochem 2017 Sep 28;38:1-8. Epub 2017 Feb 28.

Department of Radiation Oncology, Radiotherapy & OncoImmunology Laboratory, Radboud University Medical Center, Nijmegen, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.ultsonch.2017.02.035DOI Listing
September 2017

Metabolic Oligosaccharide Engineering with Alkyne Sialic Acids Confers Neuraminidase Resistance and Inhibits Influenza Reproduction.

Bioconjug Chem 2017 07 27;28(7):1811-1815. Epub 2017 Jun 27.

Laboratory of Pediatric Infectious Diseases, Radboud Center for Infectious Diseases, Radboudumc , Geert Grooteplein Zuid 32, 6525 GA Nijmegen, The Netherlands.

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http://dx.doi.org/10.1021/acs.bioconjchem.7b00224DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5520103PMC
July 2017

Metabolic sialic acid blockade lowers the activation threshold of moDCs for TLR stimulation.

Immunol Cell Biol 2017 04 22;95(4):408-415. Epub 2016 Nov 22.

Department of Tumor Immunology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Geert Grooteplein 28, 6525 GA Nijmegen, The Netherlands.

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http://dx.doi.org/10.1038/icb.2016.105DOI Listing
April 2017

photoacoustics and high frequency ultrasound imaging of mechanical high intensity focused ultrasound (HIFU) ablation.

Biomed Opt Express 2017 Apr 20;8(4):2235-2244. Epub 2017 Mar 20.

Department of Radiology and Nuclear Medicine, Medical UltraSound Imaging Centre, Radboud University Nijmegen Medical Centre, Netherlands.

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http://dx.doi.org/10.1364/BOE.8.002235DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5516825PMC
April 2017

Steering Siglec-Sialic Acid Interactions on Living Cells using Bioorthogonal Chemistry.

Angew Chem Int Ed Engl 2017 03 14;56(12):3309-3313. Epub 2017 Feb 14.

Institute for Molecules and Materials, Heyendaalseweg 135, 6525 AJ, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1002/anie.201612193DOI Listing
March 2017

Thermal and mechanical high-intensity focused ultrasound: perspectives on tumor ablation, immune effects and combination strategies.

Cancer Immunol Immunother 2017 Feb 1;66(2):247-258. Epub 2016 Sep 1.

Department of Tumor Immunology, Radboud University Medical Center, Geert Grooteplein 28, 6525 GA, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1007/s00262-016-1891-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5281669PMC
February 2017

Saponin-based adjuvants induce cross-presentation in dendritic cells by intracellular lipid body formation.

Nat Commun 2016 11 7;7:13324. Epub 2016 Nov 7.

Department of Tumor Immunology, Radboud Institute for Molecular Life Sciences, Radboud UMC, Geert Grooteplein 26, 6525 GA Nijmegen, The Netherlands.

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http://dx.doi.org/10.1038/ncomms13324DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5103066PMC
November 2016

Elevated levels of polymorphonuclear myeloid-derived suppressor cells in patients with glioblastoma highly express S100A8/9 and arginase and suppress T cell function.

Neuro Oncol 2016 09 22;18(9):1253-64. Epub 2016 Mar 22.

Tumor Immunology Laboratory, Radboud Institute for Molecular Life Sciences, Nijmegen, the Netherlands (P.R.G., B.M.S., E.D.K.-R., G.J.A.); Department of Pathology, Radboud University Medical Center, Nijmegen, the Netherlands (K.V., P.W.); Department of Neurosurgery, Radboud University Medical Center, Nijmegen, the Netherlands (S.A.J.H.B., M.L.); Department of Pathology, VU University Medical Center, Amsterdam, the Netherlands (P.W.)

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http://dx.doi.org/10.1093/neuonc/now034DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4998996PMC
September 2016

Enterovirus Exposure Uniquely Discriminates Type 1 Diabetes Patients with a Homozygous from a Heterozygous Melanoma Differentiation-Associated Protein 5/Interferon Induced with Helicase C Domain 1 A946T Genotype.

Viral Immunol 2016 09 2;29(7):389-97. Epub 2016 Aug 2.

1 Department of Tumor Immunology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center , Nijmegen, the Netherlands .

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http://dx.doi.org/10.1089/vim.2015.0140DOI Listing
September 2016

In vivo MR guided boiling histotripsy in a mouse tumor model evaluated by MRI and histopathology.

NMR Biomed 2016 06 7;29(6):721-31. Epub 2016 Apr 7.

Department of Radiology and Nuclear Medicine, Radboud University Medical Center, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1002/nbm.3520DOI Listing
June 2016

Sialic Acid Mimetics to Target the Sialic Acid-Siglec Axis.

Trends Biochem Sci 2016 06 13;41(6):519-531. Epub 2016 Apr 13.

Cluster for Molecular Chemistry, Institute for Molecules and Materials, Radboud University Nijmegen, Heyendaalseweg 135, 6525 Nijmegen AJ, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.tibs.2016.03.007DOI Listing
June 2016

Anti-GD2 mAb and Vorinostat synergize in the treatment of neuroblastoma.

Oncoimmunology 2016 Jun 28;5(6):e1164919. Epub 2016 Mar 28.

Department of Tumor Immunology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center , Nijmegen, The Netherlands.

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http://dx.doi.org/10.1080/2162402X.2016.1164919DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4938306PMC
June 2016

Enterovirus-infected β-cells induce distinct response patterns in BDCA1+ and BDCA3+ human dendritic cells.

PLoS One 2015 25;10(3):e0121670. Epub 2015 Mar 25.

Department of Tumor Immunology, Radboud university medical center, Radboud Institute for Molecular Life Sciences, Nijmegen, The Netherlands.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0121670PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4373773PMC
March 2016

Sialic Acid Glycoengineering Using an Unnatural Sialic Acid for the Detection of Sialoglycan Biosynthesis Defects and On-Cell Synthesis of Siglec Ligands.

ACS Chem Biol 2015 Oct 10;10(10):2353-63. Epub 2015 Aug 10.

Cluster for Molecular Chemistry, Institute for Molecules and Materials, Radboud University Nijmegen , Heyendaalseweg 135, 6525 AJ Nijmegen, The Netherlands.

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http://dx.doi.org/10.1021/acschembio.5b00501DOI Listing
October 2015

DC-SCRIPT Regulates IL-10 Production in Human Dendritic Cells by Modulating NF-κBp65 Activation.

J Immunol 2015 Aug 13;195(4):1498-505. Epub 2015 Jul 13.

Department of Tumor Immunology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, 6525GA Nijmegen, the Netherlands

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http://dx.doi.org/10.4049/jimmunol.1402924DOI Listing
August 2015

Development of a high-field MR-guided HIFU setup for thermal and mechanical ablation methods in small animals.

J Ther Ultrasound 2015 13;3:14. Epub 2015 Aug 13.

Department of Radiology and Nuclear Medicine, Radboud University Medical Center, Geert Grooteplein-Zuid 10, 6500 HB Nijmegen, The Netherlands.

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http://dx.doi.org/10.1186/s40349-015-0035-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4533796PMC
August 2015

Mechanical high-intensity focused ultrasound destruction of soft tissue: working mechanisms and physiologic effects.

Ultrasound Med Biol 2015 Jun 23;41(6):1500-17. Epub 2015 Mar 23.

Department of Tumor Immunology, Radboud University Medical Center, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1016/j.ultrasmedbio.2015.02.006DOI Listing
June 2015

Intra-adrenal murine TH-MYCN neuroblastoma tumors grow more aggressive and exhibit a distinct tumor microenvironment relative to their subcutaneous equivalents.

Cancer Immunol Immunother 2015 May 17;64(5):563-72. Epub 2015 Feb 17.

Department of Tumor Immunology, Radboud Institute for Molecular Life Sciences/278 TIL, Radboud University Medical Center, Post Box 9101, 6500 HB, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1007/s00262-015-1663-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4412512PMC
May 2015

Increase in both CD14-positive and CD15-positive myeloid-derived suppressor cell subpopulations in the blood of patients with glioma but predominance of CD15-positive myeloid-derived suppressor cells in glioma tissue.

J Neuropathol Exp Neurol 2015 May;74(5):390-400

From the Tumor Immunology Laboratory, Radboud Institute for Molecular Life Sciences (PRG, BMS, EDK-R, GJA); and Departments of Pathology (KV, PW) and Neurosurgery (HMJMP-B, ML), Radboud University Medical Center, Nijmegen; and Department of Pathology, VU University Medical Center, Amsterdam (PW), the Netherlands.

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http://dx.doi.org/10.1097/NEN.0000000000000183DOI Listing
May 2015

Disease mutations in CMP-sialic acid transporter SLC35A1 result in abnormal α-dystroglycan O-mannosylation, independent from sialic acid.

Hum Mol Genet 2015 Apr 30;24(8):2241-6. Epub 2014 Dec 30.

Department of Neurology, Translational Metabolic Laboratory, Department of Laboratory Medicine,

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http://dx.doi.org/10.1093/hmg/ddu742DOI Listing
April 2015

DC-SCRIPT is a novel regulator of the tumor suppressor gene CDKN2B and induces cell cycle arrest in ERα-positive breast cancer cells.

Breast Cancer Res Treat 2015 Feb 8;149(3):693-703. Epub 2015 Feb 8.

Department of Tumor Immunology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, 6500 HB, Nijmegen, The Netherlands,

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http://dx.doi.org/10.1007/s10549-015-3281-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4326655PMC
February 2015

Targeted delivery of a sialic acid-blocking glycomimetic to cancer cells inhibits metastatic spread.

ACS Nano 2015 Jan 14;9(1):733-45. Epub 2015 Jan 14.

Department of Tumor Immunology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center , Geert Grooteplein 28, 6525 GA Nijmegen, The Netherlands.

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http://dx.doi.org/10.1021/nn5061964DOI Listing
January 2015

TLR9 independent interferon α production by neutrophils on NETosis in response to circulating chromatin, a key lupus autoantigen.

Ann Rheum Dis 2014 Dec 7;73(12):2199-207. Epub 2013 Sep 7.

Department of Immunology, University of Tübingen, Institute for Cell Biology, Tübingen, Germany University of Paris 13, Sorbonne Paris Cité, EA4222, Li2P, Bobigny, France.

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http://dx.doi.org/10.1136/annrheumdis-2012-203041DOI Listing
December 2014

Sweet escape: sialic acids in tumor immune evasion.

Biochim Biophys Acta 2014 Aug 12;1846(1):238-46. Epub 2014 Jul 12.

Department of Tumor Immunology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, PO Box 9101, 6500 HB Nijmegen, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.bbcan.2014.07.005DOI Listing
August 2014

HDAC inhibitors and immunotherapy; a double edged sword?

Oncotarget 2014 Aug;5(16):6558-72

Department of Tumor Immunology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Centre, Nijmegen, The Netherlands.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4196144PMC
http://dx.doi.org/10.18632/oncotarget.2289DOI Listing
August 2014

Sialic acids sweeten a tumor's life.

Cancer Res 2014 Jun 15;74(12):3199-204. Epub 2014 May 15.

Authors' Affiliation: Department of Tumor Immunology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, the Netherlands

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http://dx.doi.org/10.1158/0008-5472.CAN-14-0728DOI Listing
June 2014

Vitamin D controls murine and human plasmacytoid dendritic cell function.

J Invest Dermatol 2014 May 25;134(5):1255-1264. Epub 2013 Nov 25.

Department of Tumor Immunology, Nijmegen Centre for Molecular Life Sciences, Radboud University Medical Centre, Nijmegen, The Netherlands. Electronic address:

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http://dx.doi.org/10.1038/jid.2013.501DOI Listing
May 2014

A transplantable TH-MYCN transgenic tumor model in C57Bl/6 mice for preclinical immunological studies in neuroblastoma.

Int J Cancer 2014 Mar 14;134(6):1335-45. Epub 2013 Sep 14.

Department of Tumor Immunology, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands; Department of Pediatric Oncology, Radboud University, Nijmegen Medical Centre, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1002/ijc.28463DOI Listing
March 2014

Differential susceptibility and response of primary human myeloid BDCA1(+) dendritic cells to infection with different Enteroviruses.

PLoS One 2013 24;8(4):e62502. Epub 2013 Apr 24.

Department of Tumor Immunology, Nijmegen Centre for Molecular Life Sciences & Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0062502PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3634769PMC
December 2013

Nuclear receptor expression patterns in murine plasmacytoid and conventional dendritic cells.

Mol Immunol 2013 Oct 15;55(3-4):409-17. Epub 2013 Apr 15.

Department of Tumor Immunology, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1016/j.molimm.2013.03.020DOI Listing
October 2013

Targeting aberrant sialylation in cancer cells using a fluorinated sialic acid analog impairs adhesion, migration, and in vivo tumor growth.

Mol Cancer Ther 2013 Oct 23;12(10):1935-46. Epub 2013 Aug 23.

Corresponding Author: Gosse J. Adema, 278 Department of Tumor Immunology, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre P.O. Box 9101, Nijmegen 6500 HB, the Netherlands.

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http://mct.aacrjournals.org/cgi/doi/10.1158/1535-7163.MCT-13
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http://dx.doi.org/10.1158/1535-7163.MCT-13-0279DOI Listing
October 2013

An Altered gp100 Peptide Ligand with Decreased Binding by TCR and CD8α Dissects T Cell Cytotoxicity from Production of Cytokines and Activation of NFAT.

Front Immunol 2013 4;4:270. Epub 2013 Sep 4.

Laboratory of Experimental Tumor Immunology, Department Medical Oncology, Erasmus MC Cancer Institute , Rotterdam , Netherlands.

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http://dx.doi.org/10.3389/fimmu.2013.00270DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3762364PMC
September 2013

Antigen cross-presentation by dendritic cell subsets: one general or all sergeants?

Trends Immunol 2013 Aug 27;34(8):361-70. Epub 2013 Mar 27.

Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, Tumor Immunology Laboratory, Geert Grooteplein 28, 6525 GA, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1016/j.it.2013.02.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4351710PMC
August 2013

DC-SCRIPT regulates glucocorticoid receptor function and expression of its target GILZ in dendritic cells.

J Immunol 2013 Apr 25;190(7):3172-9. Epub 2013 Feb 25.

Department of Tumor Immunology, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, 6500 HB Nijmegen, The Netherlands.

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http://dx.doi.org/10.4049/jimmunol.1201776DOI Listing
April 2013

Blueprints of signaling interactions between pattern recognition receptors: implications for the design of vaccine adjuvants.

Clin Vaccine Immunol 2013 Mar 23;20(3):427-32. Epub 2013 Jan 23.

Department of Medicine, Radboud University Nijmegen Medical Center, Nijmegen, the Netherlands.

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http://dx.doi.org/10.1128/CVI.00703-12DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3592350PMC
March 2013

Targeting of 111In-labeled dendritic cell human vaccines improved by reducing number of cells.

Clin Cancer Res 2013 Mar 4;19(6):1525-33. Epub 2013 Feb 4.

Department of Tumor Immunology, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre (RUNMC), Nijmegen, The Netherlands.

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http://dx.doi.org/10.1158/1078-0432.CCR-12-1879DOI Listing
March 2013

The immunosuppressive tumour network: myeloid-derived suppressor cells, regulatory T cells and natural killer T cells.

Immunology 2013 Feb;138(2):105-15

Department of Tumour Immunology, Nijmegen Centre for Molecular Life Sciences, Nijmegen, the Netherlands.

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http://doi.wiley.com/10.1111/imm.12036
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http://dx.doi.org/10.1111/imm.12036DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3575763PMC
February 2013

DC-SCRIPT: AR and VDR regulator lost upon transformation of prostate epithelial cells.

Prostate 2012 Dec 2;72(16):1708-17. Epub 2012 Apr 2.

Department of Tumor Immunology, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1002/pros.22522DOI Listing
December 2012

Skin-test infiltrating lymphocytes early predict clinical outcome of dendritic cell-based vaccination in metastatic melanoma.

Cancer Res 2012 Dec 24;72(23):6102-10. Epub 2012 Sep 24.

Department of Tumor Immunology, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1158/0008-5472.CAN-12-2479DOI Listing
December 2012

Cytokine and chemokine production by human pancreatic islets upon enterovirus infection.

Diabetes 2012 Aug 17;61(8):2030-6. Epub 2012 May 17.

1Department of Tumor Immunology, Nijmegen Center for Molecular Life Sciences, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands.

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http://dx.doi.org/10.2337/db11-1547DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3402326PMC
August 2012

Dendritic cell-specific transcript: dendritic cell marker and regulator of TLR-induced cytokine production.

J Immunol 2012 Jul 21;189(1):138-45. Epub 2012 May 21.

Department of Tumor Immunology, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, 6525 GA Nijmegen, The Netherlands.

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http://dx.doi.org/10.4049/jimmunol.1103709DOI Listing
July 2012

Effect of administration of apoptotic blebs on disease development in lupus mice.

Autoimmunity 2012 Jun 2;45(4):290-7. Epub 2012 Apr 2.

Nephrology Research Laboratory, Nijmegen Centre for Molecular Life Sciences, Department of Nephrology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.

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http://dx.doi.org/10.3109/08916934.2012.664668DOI Listing
June 2012

The C-type lectin receptor CLEC9A mediates antigen uptake and (cross-)presentation by human blood BDCA3+ myeloid dendritic cells.

Blood 2012 Mar 10;119(10):2284-92. Epub 2012 Jan 10.

Department of Tumor Immunology, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, The Netherlands.

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http://dx.doi.org/10.1182/blood-2011-08-373944DOI Listing
March 2012

Analysis of genes regulated by the transcription factor LUMAN identifies ApoA4 as a target gene in dendritic cells.

Mol Immunol 2012 Feb 30;50(1-2):66-73. Epub 2011 Dec 30.

Department of Tumor Immunology, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.

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http://linkinghub.elsevier.com/retrieve/pii/S016158901100826
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http://dx.doi.org/10.1016/j.molimm.2011.12.003DOI Listing
February 2012

Immunocombination therapy for high-risk neuroblastoma.

Immunotherapy 2012 Feb;4(2):163-74

Department of Tumor Immunology, Nijmegen Centre for Molecular Life Sciences/278 TIL, 6500 HB Nijmegen, The Netherlands.

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https://www.futuremedicine.com/doi/10.2217/imt.11.169
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February 2012

Saponin-based adjuvants create a highly effective anti-tumor vaccine when combined with in situ tumor destruction.

Vaccine 2012 Jan 30;30(4):737-44. Epub 2011 Nov 30.

Department of Tumor Immunology, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, Geert Grooteplein 28, 6525 GA Nijmegen, The Netherlands.

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http://dx.doi.org/10.1016/j.vaccine.2011.11.080DOI Listing
January 2012

Regulatory T cells in melanoma: the final hurdle towards effective immunotherapy?

Lancet Oncol 2012 Jan;13(1):e32-42

Department of Tumour Immunology, Nijmegen Centre for Molecular Life Sciences, Nijmegen, Netherlands.

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http://dx.doi.org/10.1016/S1470-2045(11)70155-3DOI Listing
January 2012

DC-STAMP knock-down deregulates cytokine production and T-cell stimulatory capacity of LPS-matured dendritic cells.

BMC Immunol 2011 Oct 6;12:57. Epub 2011 Oct 6.

Department of Tumor Immunology, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1186/1471-2172-12-57DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3199277PMC
October 2011

Clinical significance of the nuclear receptor co-regulator DC-SCRIPT in breast cancer: an independent retrospective validation study.

Breast Cancer Res 2010 1;12(6):R103. Epub 2010 Dec 1.

Department of Medical Oncology, Josephine Nefkens Institute and Cancer Genomics Centre, Erasmus Medical Center, Rotterdam, GE, The Netherlands.

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http://dx.doi.org/10.1186/bcr2786DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3046448PMC
September 2011

Route of administration modulates the induction of dendritic cell vaccine-induced antigen-specific T cells in advanced melanoma patients.

Clin Cancer Res 2011 Sep 19;17(17):5725-35. Epub 2011 Jul 19.

Department of Medical Oncology,Nijmegen Centre for Molecular Life Sciences, and Laboratory of Medical Immunology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1158/1078-0432.CCR-11-1261DOI Listing
September 2011

Antigen localization controls T cell-mediated tumor immunity.

J Immunol 2011 Aug 24;187(3):1281-8. Epub 2011 Jun 24.

Department of Tumor Immunology, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, 6525GA Nijmegen, The Netherlands.

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http://dx.doi.org/10.4049/jimmunol.1003905DOI Listing
August 2011

Sorafenib reduces the percentage of tumour infiltrating regulatory T cells in renal cell carcinoma patients.

Int J Cancer 2011 Jul 12;129(2):507-12. Epub 2010 Nov 12.

Department of Medical Oncology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.

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http://doi.wiley.com/10.1002/ijc.25674
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July 2011

DEC-205 mediates antigen uptake and presentation by both resting and activated human plasmacytoid dendritic cells.

Eur J Immunol 2011 Apr 17;41(4):1014-23. Epub 2011 Mar 17.

Department of Tumor Immunology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.

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http://doi.wiley.com/10.1002/eji.201040790
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April 2011

Multifaceted effects of synthetic TLR2 ligand and Legionella pneumophilia on Treg-mediated suppression of T cell activation.

BMC Immunol 2011 Mar 24;12:23. Epub 2011 Mar 24.

Department of Tumor Immunology, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.

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http://bmcimmunol.biomedcentral.com/articles/10.1186/1471-21
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3078900PMC
March 2011

Frequency of circulating Tregs with demethylated FOXP3 intron 1 in melanoma patients receiving tumor vaccines and potentially Treg-depleting agents.

Clin Cancer Res 2011 Feb 21;17(4):841-8. Epub 2010 Dec 21.

Department of Medical Oncology, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, The Netherlands.

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http://dx.doi.org/10.1158/1078-0432.CCR-10-2227DOI Listing
February 2011

Toll-like receptor expression and function in human dendritic cell subsets: implications for dendritic cell-based anti-cancer immunotherapy.

Cancer Immunol Immunother 2010 Oct 5;59(10):1573-82. Epub 2010 Mar 5.

Department of Tumor Immunology, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, PO Box 9101, 6500 HB, Nijmegen, The Netherlands.

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http://link.springer.com/10.1007/s00262-010-0833-1
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October 2010

Cross-talk between human dendritic cell subsets influences expression of RNA sensors and inhibits picornavirus infection.

J Innate Immun 2010 20;2(4):360-70. Epub 2010 Mar 20.

Department of Tumor Immunology, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1159/000300568DOI Listing
October 2010

Dendritic cell vaccination in combination with anti-CD25 monoclonal antibody treatment: a phase I/II study in metastatic melanoma patients.

Clin Cancer Res 2010 Oct 24;16(20):5067-78. Epub 2010 Aug 24.

Department of Medical Oncology, Laboratory of Medical Immunology, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, Nijmegen, the Netherlands.

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http://dx.doi.org/10.1158/1078-0432.CCR-10-1757DOI Listing
October 2010

The role of dendritic cells in the pathogenesis of systemic lupus erythematosus.

Arthritis Res Ther 2010 26;12(2):207. Epub 2010 Apr 26.

Nephrology Research Laboratory, Nijmegen Centre for Molecular Life Sciences, Department of Nephrology, Radboud University Nijmegen Medical Centre, 6500 HB Nijmegen, The Netherlands.

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http://dx.doi.org/10.1186/ar2966DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2888204PMC
September 2010

Prognostic significance and mechanism of Treg infiltration in human brain tumors.

J Neuroimmunol 2010 Aug;225(1-2):195-9

Nijmegen Centre for Molecular Life Sciences, Department of Tumor Immunology, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1016/j.jneuroim.2010.05.020DOI Listing
August 2010

Commonly used prophylactic vaccines as an alternative for synthetically produced TLR ligands to mature monocyte-derived dendritic cells.

Blood 2010 Jul 27;116(4):564-74. Epub 2010 Apr 27.

Department of Tumor Immunology, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1182/blood-2009-11-251884DOI Listing
July 2010

DC-STAMP interacts with ER-resident transcription factor LUMAN which becomes activated during DC maturation.

Mol Immunol 2010 Jul 23;47(11-12):1963-73. Epub 2010 May 23.

Department of Tumor Immunology, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, PO Box 9101, 6500 HB Nijmegen, The Netherlands.

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http://dx.doi.org/10.1016/j.molimm.2010.04.019DOI Listing
July 2010

An alternatively spliced CXCL16 isoform expressed by dendritic cells is a secreted chemoattractant for CXCR6+ cells.

J Leukoc Biol 2010 Jun 24;87(6):1029-39. Epub 2010 Feb 24.

Laboratory Medicine, Laboratory of Hematology and Tumor Immunology, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.

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http://doi.wiley.com/10.1189/jlb.0709482
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3210559PMC
June 2010

Detection of enterovirus RNA in peripheral blood mononuclear cells of type 1 diabetic patients beyond the stage of acute infection.

Viral Immunol 2010 Feb;23(1):99-104

Department of Medical Microbiology, Radboud University Nijmegen Medical Centre and Nijmegen Centre for Molecular Life Sciences, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1089/vim.2009.0072DOI Listing
February 2010

DC-SCRIPT: nuclear receptor modulation and prognostic significance in primary breast cancer.

J Natl Cancer Inst 2010 Jan 14;102(1):54-68. Epub 2009 Dec 14.

Department of Tumor Immunology, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1093/jnci/djp441DOI Listing
January 2010

Toll-like receptor triggering in cord blood mesenchymal stem cells.

J Cell Mol Med 2009 Sep;13(9B):3415-26

Department of Tumor Immunology, Nijmegen Centre for Molecular Life Sciences, Geert Grooteplein, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1111/j.1582-4934.2009.00653.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4516497PMC
September 2009