Publications by authors named "Gordon Mills"

100Publications

Inhibition of the ATM/Chk2 axis promotes cGAS/STING signaling in ARID1A-deficient tumors.

J Clin Invest 2020 Oct 5. Epub 2020 Oct 5.

Department of Clinical Cancer Prevention, University of Texas MD Anderson Cancer Center, Houston, Texas, USA.

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http://dx.doi.org/10.1172/JCI130445DOI Listing
October 2020

Multi-omics prediction of immune-related adverse events during checkpoint immunotherapy.

Nat Commun 2020 10 2;11(1):4946. Epub 2020 Oct 2.

Department of Biochemistry and Molecular Biology, The University of Texas Health Science Center at Houston McGovern Medical School, Houston, TX, 77030, USA.

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http://dx.doi.org/10.1038/s41467-020-18742-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7532211PMC
October 2020

The roles of variants in pancreatic cancer development and their potential impact on cancer immunotherapy.

Autophagy 2020 Oct 18;16(10):1923-1924. Epub 2020 Aug 18.

Cell, Developmental & Cancer Biology, Oregon Health & Science University , Portland, OR, USA.

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http://dx.doi.org/10.1080/15548627.2020.1802091DOI Listing
October 2020

Candidate biomarker assessment for pharmacological response.

Transl Oncol 2020 Oct 8;13(10):100830. Epub 2020 Jul 8.

Developmental Therapeutic Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, United States of America.

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http://dx.doi.org/10.1016/j.tranon.2020.100830DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7348063PMC
October 2020

p85β regulates autophagic degradation of AXL to activate oncogenic signaling.

Nat Commun 2020 05 8;11(1):2291. Epub 2020 May 8.

School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, Hong Kong.

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http://dx.doi.org/10.1038/s41467-020-16061-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7210311PMC
May 2020

Systems approach to rational combination therapy: PARP inhibitors.

Biochem Soc Trans 2020 06;48(3):1101-1108

Department of Cell, Development and Cancer Biology, Knight Cancer Institute, Oregon Health and Sciences University, Portland, OR 97201, U.S.A.

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http://dx.doi.org/10.1042/BST20191092DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7329579PMC
June 2020

Predicting Cancer Cell Line Dependencies From the Protein Expression Data of Reverse-Phase Protein Arrays.

JCO Clin Cancer Inform 2020 Apr;4:357-366

Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, TX.

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http://dx.doi.org/10.1200/CCI.19.00144DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7259880PMC
April 2020

Which path to follow? Utilizing proteomics to improve therapy choices for breast cancer patients.

Expert Rev Proteomics 2020 Mar 22;17(3):187-190. Epub 2020 Apr 22.

Department of Cell, Developmental & Cancer Biology, Oregon Health & Science University, Portland, OR, USA.

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http://dx.doi.org/10.1080/14789450.2020.1757442DOI Listing
March 2020

Sex-associated molecular differences for cancer immunotherapy.

Nat Commun 2020 04 14;11(1):1779. Epub 2020 Apr 14.

Department of Biochemistry and Molecular Biology, The University of Texas Health Science Center at Houston McGovern Medical School, Houston, TX, 77030, USA.

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http://dx.doi.org/10.1038/s41467-020-15679-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7156379PMC
April 2020

Relationship Between Response and Dose in Published, Contemporary Phase I Oncology Trials.

J Natl Compr Canc Netw 2020 04;18(4):428-433

Division of Hematology Oncology, Knight Cancer Institute.

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http://dx.doi.org/10.6004/jnccn.2019.7375DOI Listing
April 2020

Comprehensive assessment of computational algorithms in predicting cancer driver mutations.

Genome Biol 2020 02 20;21(1):43. Epub 2020 Feb 20.

Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.

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http://dx.doi.org/10.1186/s13059-020-01954-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7033911PMC
February 2020

Mutant P53 induces MELK expression by release of wild-type P53-dependent suppression of FOXM1.

NPJ Breast Cancer 2020 3;6. Epub 2020 Jan 3.

1Department of Clinical Cancer Prevention, The University of Texas MD Anderson Cancer Center, Houston, Texas USA.

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http://dx.doi.org/10.1038/s41523-019-0143-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6941974PMC
January 2020

miRNA551b-3p Activates an Oncostatin Signaling Module for the Progression of Triple-Negative Breast Cancer.

Cell Rep 2019 12;29(13):4389-4406.e10

Department of Obstetrics and Gynecology, Medical College of Wisconsin, Milwaukee, WI 53226, USA; Department of Physiology, Medical College of Wisconsin, Milwaukee, WI 53226, USA; Medical College of Wisconsin Cancer Center, Medical College of Wisconsin, Milwaukee, WI 53226, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2019.11.085DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7380555PMC
December 2019

Using Reverse Phase Protein Array (RPPA) to Identify and Target Adaptive Resistance.

Adv Exp Med Biol 2019 ;1188:251-266

Knight Cancer Institute, Oregon Health and Sciences University, Portland, OR, USA.

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http://dx.doi.org/10.1007/978-981-32-9755-5_14DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7382818PMC
December 2019

Clinical relevance of TP53 hotspot mutations in high-grade serous ovarian cancers.

Br J Cancer 2020 02 29;122(3):405-412. Epub 2019 Nov 29.

Precision Oncology, Knight Cancer Institute, Oregon Health & Science University, Portland, OR, USA.

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http://dx.doi.org/10.1038/s41416-019-0654-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7000721PMC
February 2020

Genome-Wide Profiling of Acquired Uniparental Disomy Reveals Prognostic Factors in Head and Neck Squamous Cell Carcinoma.

Neoplasia 2019 11 14;21(11):1102-1109. Epub 2019 Nov 14.

Department of Systems Biology, The University of Texas MD Anderson Cancer Center, Houston, TX; Department of Cell, Developmental & Cancer Biology, School of Medicine, Oregon Health Science University, Portland, OR; Precision Oncology, Knight Cancer Institute, Portland, OR.

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http://dx.doi.org/10.1016/j.neo.2019.08.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6889229PMC
November 2019

MCP-1/CCR-2 axis in adipocytes and cancer cell respectively facilitates ovarian cancer peritoneal metastasis.

Oncogene 2020 Feb 8;39(8):1681-1695. Epub 2019 Nov 8.

Department of Gynecology and Obstetrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, Hubei, PR China.

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http://dx.doi.org/10.1038/s41388-019-1090-1DOI Listing
February 2020

Transcriptional landscape and clinical utility of enhancer RNAs for eRNA-targeted therapy in cancer.

Nat Commun 2019 10 8;10(1):4562. Epub 2019 Oct 8.

Department of Biochemistry and Molecular Biology, McGovern Medical School at The University of Texas Health Science Center at Houston, Houston, TX, 77030, USA.

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http://dx.doi.org/10.1038/s41467-019-12543-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6783481PMC
October 2019

Proteomics advances for precision therapy in ovarian cancer.

Expert Rev Proteomics 2019 10 13;16(10):841-850. Epub 2019 Sep 13.

Knight Cancer Institute and Cell, Developmental and Cancer Biology, Oregon Health and Science University , Portland , OR , USA.

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https://www.tandfonline.com/doi/full/10.1080/14789450.2019.1
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http://dx.doi.org/10.1080/14789450.2019.1666004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6814571PMC
October 2019

Dynamic clonal remodelling in breast cancer metastases is associated with subtype conversion.

Eur J Cancer 2019 10 4;120:54-64. Epub 2019 Sep 4.

GEICAM (Grupo GEICAM de Investigación en Cáncer de Mama), Madrid, Spain; Centro de Investigación Biomédica en Red de Oncología, CIBERONC-ISCIII, Spain; IMIM Hospital del Mar Medical Research Institute; Barcelona, Spain; Medical Oncology Department Hospital del Mar, Barcelona, Barcelona, Spain; Universitat Pompeu Fabra, Barcelona, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.ejca.2019.07.003DOI Listing
October 2019

Comprehensive characterization of circular RNAs in ~ 1000 human cancer cell lines.

Genome Med 2019 08 26;11(1):55. Epub 2019 Aug 26.

Department of Biochemistry and Molecular Biology, McGovern Medical School at The University of Texas Health Science Center at Houston, Houston, TX, 77030, USA.

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http://dx.doi.org/10.1186/s13073-019-0663-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6709551PMC
August 2019

The phosphatase PPM1A inhibits triple negative breast cancer growth by blocking cell cycle progression.

NPJ Breast Cancer 2019 26;5:22. Epub 2019 Jul 26.

1Department of Clinical Cancer Prevention, The University of Texas M.D. Anderson Cancer Center, Texas, USA.

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http://www.nature.com/articles/s41523-019-0118-6
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http://dx.doi.org/10.1038/s41523-019-0118-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6659706PMC
July 2019

TCPA v3.0: An Integrative Platform to Explore the Pan-Cancer Analysis of Functional Proteomic Data.

Mol Cell Proteomics 2019 08 14;18(8 suppl 1):S15-S25. Epub 2019 Jun 14.

‡Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas

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http://dx.doi.org/10.1074/mcp.RA118.001260DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6692772PMC
August 2019

Sequential Therapy with PARP and WEE1 Inhibitors Minimizes Toxicity while Maintaining Efficacy.

Cancer Cell 2019 06;35(6):851-867.e7

Department of Systems Biology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA; Department of Cell, Development and Cancer Biology, Oregon Health and Sciences University, Portland, OR 97201, USA; Knight Cancer Institute, Portland, OR 97201, USA.

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http://dx.doi.org/10.1016/j.ccell.2019.05.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6642675PMC
June 2019

The DNA Endonuclease Mus81 Regulates ZEB1 Expression and Serves as a Target of BET4 Inhibitors in Gastric Cancer.

Mol Cancer Ther 2019 08 29;18(8):1439-1450. Epub 2019 May 29.

Department of Clinical Cancer Prevention, the University of Texas MD Anderson Cancer Center, Houston, Texas.

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http://dx.doi.org/10.1158/1535-7163.MCT-18-0833DOI Listing
August 2019

Advancing Drug Development in Gynecologic Malignancies.

Clin Cancer Res 2019 08 24;25(16):4874-4880. Epub 2019 May 24.

University of Cincinnati Cancer Institute, Cincinnati, Ohio.

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http://dx.doi.org/10.1158/1078-0432.CCR-19-0619DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6697564PMC
August 2019

Molecular mechanisms and pathobiology of oncogenic fusion transcripts in epithelial tumors.

Oncotarget 2019 Mar 12;10(21):2095-2111. Epub 2019 Mar 12.

Department of Systems Biology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

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http://dx.doi.org/10.18632/oncotarget.26777DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6459343PMC
March 2019

Integrated transcriptomic-genomic tool Texomer profiles cancer tissues.

Nat Methods 2019 05 15;16(5):401-404. Epub 2019 Apr 15.

Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

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http://dx.doi.org/10.1038/s41592-019-0388-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7337246PMC
May 2019

Targeting mitochondria in cancer therapy could provide a basis for the selective anti-cancer activity.

PLoS One 2019 25;14(3):e0205623. Epub 2019 Mar 25.

Department of Molecular and Medical Genetics, Knight Cancer Institute, Oregon Health and Science University, Portland, Oregon, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0205623PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6433232PMC
November 2019

Protein Kinase C Quality Control by Phosphatase PHLPP1 Unveils Loss-of-Function Mechanism in Cancer.

Mol Cell 2019 04 20;74(2):378-392.e5. Epub 2019 Mar 20.

Department of Pharmacology, University of California at San Diego, La Jolla, CA 92093, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2019.02.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6504549PMC
April 2019

Therapeutic Clues from an Integrated Omic Assessment of East Asian Triple Negative Breast Cancers.

Cancer Cell 2019 03;35(3):341-343

Center for Spatial Systems Biomedicine, Department of Biomedical Engineering, Oregon Health & Science University, Portland, OR 97201, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2019.02.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6499473PMC
March 2019

Deregulated Gab2 phosphorylation mediates aberrant AKT and STAT3 signaling upon PIK3R1 loss in ovarian cancer.

Nat Commun 2019 02 12;10(1):716. Epub 2019 Feb 12.

School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, Hong Kong.

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http://dx.doi.org/10.1038/s41467-019-08574-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6372715PMC
February 2019

Genome-Wide Analysis of Head and Neck Squamous Cell Carcinomas Reveals HPV, TP53, Smoking and Alcohol-Related Allele-Based Acquired Uniparental Disomy Genomic Alterations.

Neoplasia 2019 02 4;21(2):197-205. Epub 2019 Jan 4.

Department of Systems Biology, The University of Texas MD Anderson Cancer Center, Houston, TX; Department of Cell, Developmental & Cancer Biology, Oregon Health & Science University, Portland, OR; Precision Oncology, Knight Cancer Institute, Oregon Health & Science University, Portland, OR.

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https://linkinghub.elsevier.com/retrieve/pii/S14765586183060
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http://dx.doi.org/10.1016/j.neo.2018.12.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6321975PMC
February 2019

Neomorphic PDGFRA extracellular domain driver mutations are resistant to PDGFRA targeted therapies.

Nat Commun 2018 11 2;9(1):4583. Epub 2018 Nov 2.

Department of Systems Biology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX, 77030, USA.

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http://www.nature.com/articles/s41467-018-06949-w
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http://dx.doi.org/10.1038/s41467-018-06949-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6214970PMC
November 2018

Comprehensive Molecular Characterization of the Hippo Signaling Pathway in Cancer.

Cell Rep 2018 10;25(5):1304-1317.e5

Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA; Graduate Program in Quantitative and Computational Biosciences, Baylor College of Medicine, Houston, TX 77030, USA; Department of Systems Biology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S22111247183156
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http://dx.doi.org/10.1016/j.celrep.2018.10.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6326181PMC
October 2018

Confocal Fluorescence Microscopy Platform Suitable for Rapid Evaluation of Small Fragments of Tissue in Surgical Pathology Practice.

Arch Pathol Lab Med 2019 03 30;143(3):305-313. Epub 2018 Oct 30.

From the Departments of Pathology and Laboratory Medicine (Dr Krishnamurthy) and Pathology (Dr Ban), the Sheikh Khalifa Bin Zayed Al Nahyan Institute for Personalized Cancer Therapy (Drs Ban, Shaw, and Mills), and the Department of Interventional Radiology (Drs Sheth, Tam, Gupta, and Sabir), The University of Texas MD Anderson Cancer Center, Houston.

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http://www.archivesofpathology.org/doi/10.5858/arpa.2018-035
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http://dx.doi.org/10.5858/arpa.2018-0352-OADOI Listing
March 2019

State-of-the-art strategies for targeting the DNA damage response in cancer.

Nat Rev Clin Oncol 2019 02;16(2):81-104

Department of Investigational Cancer Therapeutics (Phase I Program), The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

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http://www.nature.com/articles/s41571-018-0114-z
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http://dx.doi.org/10.1038/s41571-018-0114-zDOI Listing
February 2019

Systems biology approach reveals a link between mTORC1 and G2/M DNA damage checkpoint recovery.

Nat Commun 2018 09 28;9(1):3982. Epub 2018 Sep 28.

Department of Clinical Cancer Prevention, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.

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http://www.nature.com/articles/s41467-018-05639-x
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http://dx.doi.org/10.1038/s41467-018-05639-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6162282PMC
September 2018

Modulation of the Hippo pathway and organ growth by RNA processing proteins.

Proc Natl Acad Sci U S A 2018 10 26;115(42):10684-10689. Epub 2018 Sep 26.

Vlaams Instituut voor Biotechnologie (VIB) Center for Cancer Biology, University of Leuven, 3000 Leuven, Belgium;

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http://www.pnas.org/lookup/doi/10.1073/pnas.1807325115
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http://dx.doi.org/10.1073/pnas.1807325115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6196505PMC
October 2018

Author Correction: Estrogen-related receptor gamma functions as a tumor suppressor in gastric cancer.

Nat Commun 2018 08 31;9(1):3599. Epub 2018 Aug 31.

ASAN Institute for Life Sciences, ASAN Medical Center, University of Ulsan College of Medicine, Seoul, 05505, Republic of Korea.

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http://dx.doi.org/10.1038/s41467-018-06061-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6119198PMC
August 2018