Publications by authors named "Gordon Keller"

99Publications

BMP10 Signaling Promotes the Development of Endocardial Cells from Human Pluripotent Stem Cell-Derived Cardiovascular Progenitors.

Cell Stem Cell 2021 Jan 2;28(1):96-111.e7. Epub 2020 Nov 2.

McEwen Stem Cell Institute, University Health Network, Toronto, ON M5G1L7, Canada; Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G1L7, Canada; Department of Medical Biophysics, University of Toronto, Toronto, ON M5G1L7, Canada. Electronic address:

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January 2021

Single-Cell Mechanical Analysis of Human Pluripotent Stem Cell-Derived Cardiomyocytes for Drug Testing and Pathophysiological Studies.

Stem Cell Reports 2020 09 6;15(3):587-596. Epub 2020 Aug 6.

Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, POB 9649, Haifa 3109601, Israel; Cardiolology Department, Rambam Health Care Campus, Haifa, Israel. Electronic address:

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September 2020

Generation of Functional Liver Sinusoidal Endothelial Cells from Human Pluripotent Stem-Cell-Derived Venous Angioblasts.

Cell Stem Cell 2020 Aug 7;27(2):254-269.e9. Epub 2020 Jul 7.

McEwen Stem Cell Institute, University Health Network, Toronto, ON M5G1L7, Canada; Department of Medical Biophysics, University of Toronto, Toronto, ON M5G1L7, Canada. Electronic address:

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August 2020

Generating ring-shaped engineered heart tissues from ventricular and atrial human pluripotent stem cell-derived cardiomyocytes.

Nat Commun 2020 01 7;11(1):75. Epub 2020 Jan 7.

Sohnis Research Laboratory for Cardiac Electrophysiology and Regenerative Medicine, the Rappaport Faculty of Medicine and Research Institute, Technion‒Israel Institute of Technology, Haifa, Israel, POB 9649, Haifa, 3109601, Israel.

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January 2020

Human Pluripotent Stem Cell-Derived Cardiovascular Cells: From Developmental Biology to Therapeutic Applications.

Cell Stem Cell 2019 09;25(3):311-327

McEwen Stem Cell Institute, University Health Network, Toronto, ON M5G 1L7, Canada; Department of Medical Biophysics, University of Toronto, Toronto, ON M5G 1L7, Canada; Princess Margaret Cancer Center, University Health Network, Toronto, ON M5G 1L7, Canada. Electronic address:

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September 2019

Human Embryonic Stem Cell-Derived Cardiomyocytes Regenerate the Infarcted Pig Heart but Induce Ventricular Tachyarrhythmias.

Stem Cell Reports 2019 05 2;12(5):967-981. Epub 2019 May 2.

McEwen Stem Cell Institute, University Health Network, Toronto, ON M5G 1L7, Canada; Peter Munk Cardiac Centre, University Health Network, Toronto, ON M5G 2N2, Canada; University of Toronto, Toronto, ON M5G 1L7, Canada. Electronic address:

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May 2019

Ibrutinib Displays Atrial-Specific Toxicity in Human Stem Cell-Derived Cardiomyocytes.

Stem Cell Reports 2019 05 25;12(5):996-1006. Epub 2019 Apr 25.

Simon Fraser University, 8888 University Drive, Burnaby, BC V5A 1A6, Canada; University of British Columbia, 170-6371 Crescent Road, Vancouver, BC V6T 1Z2, Canada. Electronic address:

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May 2019

Essential Gene Profiles for Human Pluripotent Stem Cells Identify Uncharacterized Genes and Substrate Dependencies.

Cell Rep 2019 04;27(2):599-615.e12

Donnelly Centre, University of Toronto, Toronto, ON, Canada; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada; Canadian Institute for Advanced Research, Toronto, ON, Canada; Institute for Biomaterials and BioMedical Engineering, University of Toronto, ON, Canada. Electronic address:

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April 2019

A Platform for Generation of Chamber-Specific Cardiac Tissues and Disease Modeling.

Cell 2019 02 24;176(4):913-927.e18. Epub 2019 Jan 24.

Department of Chemical Engineering and Applied Chemistry, University of Toronto, Toronto, ON M5S 3E5, Canada; Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, ON M5S 3G9, Canada; Toronto General Hospital Research Institute, Toronto, ON M5G 2C4, Canada. Electronic address:

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February 2019

FZD4 Marks Lateral Plate Mesoderm and Signals with NORRIN to Increase Cardiomyocyte Induction from Pluripotent Stem Cell-Derived Cardiac Progenitors.

Stem Cell Reports 2018 01 14;10(1):87-100. Epub 2017 Dec 14.

Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, ON M5S 3G9, Canada; Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, ON M5S 3E1, Canada; Centre for Commercialization of Regenerative Medicine, Toronto, ON M5G 1M1, Canada; Medicine by Design: A Canada First Research Excellence Fund Program, University of Toronto, Toronto, ON M5G 1M1, Canada. Electronic address:

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January 2018

Substrate and mechanotransduction influence SERCA2a localization in human pluripotent stem cell-derived cardiomyocytes affecting functional performance.

Stem Cell Res 2017 12 16;25:107-114. Epub 2017 Oct 16.

Department of Industrial Engineering, University of Padova, via Marzolo 9, Padova 35131, Italy; Venetian Institute of Molecular Medicine, via Orus 2, Padova 35129, Italy; Shanghai Institute for Advanced Immunochemical Studies (SIAIS), ShanghaiTech University, Shanghai, China; Stem Cells & Regenerative Medicine Section, UCL Great Ormond Street Institute of Child Health, 30 Guilford Street, London WC1N 1EH, UK. Electronic address:

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December 2017

Human Stem Cell-Derived Cardiac Model of Chronic Drug Exposure.

ACS Biomater Sci Eng 2017 Sep 10;3(9):1911-1921. Epub 2016 May 10.

Toronto General Research Institute, University Health Network, 101 College Street Toronto, Ontario, Canada M5G 1L7.

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September 2017

Human Pluripotent Stem Cell-Derived Atrial and Ventricular Cardiomyocytes Develop from Distinct Mesoderm Populations.

Cell Stem Cell 2017 08;21(2):179-194.e4

McEwen Centre for Regenerative Medicine and Princess Margaret Cancer Center, University Health Network, Toronto, ON M5G 1L7, Canada; Department of Medical Biophysics, University of Toronto, Toronto, ON M5G 1L7 Canada. Electronic address:

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August 2017

Haematopoietic stem and progenitor cells from human pluripotent stem cells.

Nature 2017 05 17;545(7655):432-438. Epub 2017 May 17.

Stem Cell Transplantation Program, Division of Pediatric Hematology and Oncology, Dana-Farber Cancer Institute, Boston Children's Hospital and Dana-Farber Cancer Institute, Boston, Massachusetts 02115, USA.

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May 2017

Defined Engineered Human Myocardium With Advanced Maturation for Applications in Heart Failure Modeling and Repair.

Circulation 2017 May 6;135(19):1832-1847. Epub 2017 Feb 6.

From Institute of Pharmacology and Toxicology, University Medical Center Göttingen, Germany (M.T., J.E.H., P.B., S.S., T.M., M.-L.C.L., E.L., F.R., S.Z., E. Wettwer, W.-H.Z.); German Center for Cardiovascular Research (DZHK), partner site Göttingen, Germany (M.T., J.E.H., P.B., S.S., T.M., M.-L.C.L., E.L., F.R., S.Z., E. Wingender, W.A.L., W.-H.Z.); Institute of Bioinformatics, University Medical Center Göttingen, Germany (S.Z., E. Wingender); Stanford Cardiovascular Institute (J.R., M.W., J.D.G., J.C.W.) and Department of Radiology (J.D.G., J.C.W.), Molecular Imaging Program, Stanford University School of Medicine, CA; The Sohnis Laboratory for Cardiac Electrophysiology and Regenerative Medicine, Technion-Israel Institute of Technology, Haifa (I.K., L.G.); Institute of Pharmacology and Toxicology, Technical University Dresden, Germany (E. Wettwer, U.R.); University Medical Center Utrecht and Hubrecht Institute, The Netherlands (P.D., L.W.v.L.); Leiden University Medical Center, The Netherlands (M.J.G.); Clinic for Cardiology and Pneumology, University Medical Center Göttingen, Germany (S.K., K.T., G.H., W.A.L.); Center for Applied Technology, Beckman Research Institute, City of Hope, Duarte, CA (L.A.C.); Department of Cardiovascular Physiology, Institute of Physiology, Ruhr University Bochum, Bochum, Germany (A.U., W.A.L.); New Laura and Isaac Perlmutter Cancer Center at New York University Langone (T.A., B.N.); and McEwen Centre for Regenerative Medicine, Toronto, Canada (G.K.). The current address for Dr Hudson is Laboratory for Cardiac Regeneration, School of Biomedical Sciences, The University of Queensland, Australia.

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May 2017

Sinoatrial node cardiomyocytes derived from human pluripotent cells function as a biological pacemaker.

Nat Biotechnol 2017 Jan 12;35(1):56-68. Epub 2016 Dec 12.

McEwen Centre for Regenerative Medicine and Princess Margaret Cancer Center, University Health Network, Toronto, Ontario, Canada.

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January 2017

A view of human haematopoietic development from the Petri dish.

Nat Rev Mol Cell Biol 2017 01 23;18(1):56-67. Epub 2016 Nov 23.

McEwen Centre for Regenerative Medicine and Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario M5G 1L7, Canada.

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January 2017

Autonomous beating rate adaptation in human stem cell-derived cardiomyocytes.

Nat Commun 2016 Jan 19;7:10312. Epub 2016 Jan 19.

Department of Biomedical Engineering, Columbia University, New York, New York 10027, USA.

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January 2016

Comparison of Human Embryonic Stem Cell-Derived Cardiomyocytes, Cardiovascular Progenitors, and Bone Marrow Mononuclear Cells for Cardiac Repair.

Stem Cell Reports 2015 Nov;5(5):753-762

Center for Cardiovascular Biology, University of Washington, Seattle, WA 98109, USA; Institute for Stem Cell and Regenerative Medicine, University of Washington, Seattle, WA 98109, USA; Department of Pathology, University of Washington, Seattle, WA 98109, USA; Department of Bioengineering, University of Washington, Seattle, WA 98109, USA; Department of Medicine/Cardiology, University of Washington, Seattle, WA 98109, USA. Electronic address:

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November 2015

New markers for tracking endoderm induction and hepatocyte differentiation from human pluripotent stem cells.

Development 2015 Dec 22;142(24):4253-65. Epub 2015 Oct 22.

McEwen Centre for Regenerative Medicine, University Health Network, Toronto, Ontario, Canada M5G 1L7 Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada M5G 2M9 Princess Margaret Cancer Centre, Toronto, Ontario, Canada M5T 2M9

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December 2015

Silent IL2RG Gene Editing in Human Pluripotent Stem Cells.

Mol Ther 2016 Mar 7;24(3):582-91. Epub 2015 Oct 7.

Department of Medicine, University of Washington, Seattle, Washington, USA.

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March 2016

A Quantitative Proteomic Analysis of Hemogenic Endothelium Reveals Differential Regulation of Hematopoiesis by SOX17.

Stem Cell Reports 2015 Aug;5(2):291-304

McEwen Centre for Regenerative Medicine, University Health Network, Toronto, ON M5G 1L7, Canada. Electronic address:

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August 2015

Directed differentiation of cholangiocytes from human pluripotent stem cells.

Nat Biotechnol 2015 Aug 13;33(8):853-61. Epub 2015 Jul 13.

1] Toronto General Research Institute, University Health Network, Toronto, Ontario, Canada. [2] Division of General Surgery, University Health Network, Toronto, Ontario, Canada. [3] Department of Surgery, University of Toronto, Toronto, Ontario, Canada.

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August 2015

Generation of articular chondrocytes from human pluripotent stem cells.

Nat Biotechnol 2015 Jun 11;33(6):638-45. Epub 2015 May 11.

1] McEwen Centre for Regenerative Medicine, University Health Network, Toronto, Ontario, Canada. [2] Princess Margaret Cancer Centre, Toronto, Ontario, Canada. [3] Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada.

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June 2015

Enzymatically degradable poly(ethylene glycol) hydrogels for the 3D culture and release of human embryonic stem cell derived pancreatic precursor cell aggregates.

Acta Biomater 2015 Aug 22;22:103-10. Epub 2015 Apr 22.

Department of Chemical and Biological Engineering, University of Colorado, 3415 Colorado Avenue, Boulder, CO 80303, USA; BioFrontiers Institute, University of Colorado, 3415 Colorado Avenue, Boulder, CO 80303, USA; Material Science and Engineering Program, University of Colorado, 3415 Colorado Avenue, Boulder, CO 80303, USA. Electronic address:

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August 2015

Efficient generation of NKX6-1+ pancreatic progenitors from multiple human pluripotent stem cell lines.

Stem Cell Reports 2015 Apr 2;4(4):591-604. Epub 2015 Apr 2.

McEwen Centre for Regenerative Medicine, Toronto, ON M5G 1L7, Canada; Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 1L7, Canada.

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April 2015

Ankrd11 is a chromatin regulator involved in autism that is essential for neural development.

Dev Cell 2015 Jan 31;32(1):31-42. Epub 2014 Dec 31.

Program in Neuroscience and Mental Health, Hospital for Sick Children, Toronto, ON M5G 1L7, Canada; McEwen Center for Regenerative Medicine, University Health Network, Toronto, ON M5G 1L7, Canada; Department of Molecular Genetics, University of Toronto, Toronto, ON M5G 1X5, Canada; Department of Physiology, University of Toronto, Toronto, ON M5G 1X5, Canada. Electronic address:

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January 2015

Transforming the promise of pluripotent stem cell-derived cardiomyocytes to a therapy: challenges and solutions for clinical trials.

Can J Cardiol 2014 Nov 15;30(11):1335-49. Epub 2014 Aug 15.

Centre for Commercialization of Regenerative Medicine, Toronto, Ontario, Canada; Heart and Stroke/Richard Lewar Centre of Excellence, Toronto, Ontario, Canada; Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, Ontario, Canada; The Donnelly Centre, University of Toronto, Toronto, Ontario, Canada; Department of Chemical Engineering and Applied Chemistry, University of Toronto, Toronto, Ontario, Canada.

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November 2014

Generation of the epicardial lineage from human pluripotent stem cells.

Nat Biotechnol 2014 Oct 21;32(10):1026-35. Epub 2014 Sep 21.

1] McEwen Centre for Regenerative Medicine, University Health Network, Toronto, Ontario, Canada. [2] Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada. [3] Princess Margaret Cancer Centre, Toronto, Ontario, Canada.

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October 2014

Wnt signaling controls the specification of definitive and primitive hematopoiesis from human pluripotent stem cells.

Nat Biotechnol 2014 Jun 18;32(6):554-61. Epub 2014 May 18.

McEwen Centre for Regenerative Medicine, University Health Network, Toronto, Ontario, Canada.

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June 2014

The effect of cyclic stretch on maturation and 3D tissue formation of human embryonic stem cell-derived cardiomyocytes.

Biomaterials 2014 Mar 11;35(9):2798-808. Epub 2014 Jan 11.

Division of Cardiovascular Surgery and Toronto General Research Institute, University Health Network and Department of Surgery, Division of Cardiac Surgery, University of Toronto, Toronto, ON, Canada; McEwen Centre for Regenerative Medicine, Toronto, ON, Canada. Electronic address:

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March 2014

Microfabricated perfusable cardiac biowire: a platform that mimics native cardiac bundle.

Lab Chip 2014 Mar;14(5):869-82

Department of Chemical Engineering and Applied Chemistry, University of Toronto, 164 College St, Rm 407, Toronto, ON M5S 3G9, Canada.

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March 2014

Retinoic acid signaling is essential for embryonic hematopoietic stem cell development.

Cell 2013 Sep;155(1):215-27

McEwen Centre for Regenerative Medicine, University of Toronto, Toronto, ON M5G 1L7, Canada; Department of Medical Biophysics, University of Toronto, Toronto, ON M5G 1L7, Canada.

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September 2013

Specification of chondrocytes and cartilage tissues from embryonic stem cells.

Development 2013 Jun;140(12):2597-610

McEwen Centre for Regenerative Medicine, University Health Network, Toronto, ON, M5G 1L7, Canada.

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June 2013

Defining the path to hematopoietic stem cells.

Nat Biotechnol 2013 May;31(5):416-8

McEwen Centre for Regenerative Medicine, University Health Network, Toronto, Ontario, Canada.

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May 2013

The expression of Sox17 identifies and regulates haemogenic endothelium.

Nat Cell Biol 2013 May 21;15(5):502-10. Epub 2013 Apr 21.

McEwen Centre for Regenerative Medicine, University Health Network, Toronto, Ontario M5G 1L7, Canada.

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May 2013

Mechanism-based facilitated maturation of human pluripotent stem cell-derived cardiomyocytes.

Circ Arrhythm Electrophysiol 2013 Feb 7;6(1):191-201. Epub 2013 Feb 7.

Cardiovascular Research Center, Mount Sinai School of Medicine, New York, NY, USA.

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February 2013

Micro-arrayed human embryonic stem cells-derived cardiomyocytes for in vitro functional assay.

PLoS One 2012 12;7(11):e48483. Epub 2012 Nov 12.

Industrial Engineering Department, University of Padova, Padova, Italy.

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May 2013

Generation of beta cells from human pluripotent stem cells: Potential for regenerative medicine.

Semin Cell Dev Biol 2012 Aug 26;23(6):701-10. Epub 2012 Jun 26.

McEwen Centre for Regenerative Medicine, University Health Network, Toronto, Ontario M5G 1L7, Canada.

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August 2012

Production of de novo cardiomyocytes: human pluripotent stem cell differentiation and direct reprogramming.

Cell Stem Cell 2012 Jan;10(1):16-28

Department of Medicine, Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.

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January 2012

Rational bioprocess design for human pluripotent stem cell expansion and endoderm differentiation based on cellular dynamics.

Biotechnol Bioeng 2012 Apr 2;109(4):853-66. Epub 2011 Dec 2.

Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, Ontario, Canada.

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April 2012

Regulated expression and role of c-Myb in the cardiovascular-directed differentiation of mouse embryonic stem cells.

Circ Res 2012 Jan 23;110(2):253-64. Epub 2011 Nov 23.

Heart and Stroke Richard Lewar Centre of Excellence, University of Toronto, Toronto, ON, Canada, M5G 1L7.

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January 2012

Biophysical properties of slow potassium channels in human embryonic stem cell derived cardiomyocytes implicate subunit stoichiometry.

J Physiol 2011 Dec 24;589(Pt 24):6093-104. Epub 2011 Oct 24.

Department of Pharmacology, College of Physicians and Surgeons, Columbia University Medical Center, New York, NY 10032, USA.

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December 2011

SIRPA is a specific cell-surface marker for isolating cardiomyocytes derived from human pluripotent stem cells.

Nat Biotechnol 2011 Oct 23;29(11):1011-8. Epub 2011 Oct 23.

McEwen Centre for Regenerative Medicine, Ontario Cancer Institute, University Health Network, Toronto, Ontario, Canada.

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October 2011

An endothelial cell niche induces hepatic specification through dual repression of Wnt and Notch signaling.

Stem Cells 2011 Feb;29(2):217-28

Department of Gene and Cell Medicine, Black Family Stem Cell Institute, Mount Sinai School of Medicine, New York, New York 10029, USA.

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February 2011

Generation of anterior foregut endoderm from human embryonic and induced pluripotent stem cells.

Nat Biotechnol 2011 Mar 27;29(3):267-72. Epub 2011 Feb 27.

Department of Gene and Cell Medicine and Black Family Stem Cell Institute, Mount Sinai School of Medicine, New York, New York, USA.

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March 2011

Simple and high yielding method for preparing tissue specific extracellular matrix coatings for cell culture.

PLoS One 2010 Sep 27;5(9):e13039. Epub 2010 Sep 27.

Department of Bioengineering, University of California San Diego, La Jolla, California, United States of America.

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September 2010

Temporal specification of blood progenitors from mouse embryonic stem cells and induced pluripotent stem cells.

Development 2010 Sep 21;137(17):2829-39. Epub 2010 Jul 21.

McEwen Centre for Regenerative Medicine, University Health Network, Toronto, ON, Canada.

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September 2010

Directed differentiation of hematopoietic precursors and functional osteoclasts from human ES and iPS cells.

Blood 2010 Apr 11;115(14):2769-76. Epub 2010 Jan 11.

Department of Craniofacial Development and Orthodontics, Guy's Hospital, King's College London, London, UK.

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April 2010

Generation of monoclonal antibodies specific for cell surface molecules expressed on early mouse endoderm.

Stem Cells 2009 Sep;27(9):2103-13

Department of Pathology, Center for Cellular and Molecular Therapeutics; Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.

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September 2009

Site-specific integration of adeno-associated virus involves partial duplication of the target locus.

Proc Natl Acad Sci U S A 2009 May 16;106(18):7571-6. Epub 2009 Apr 16.

Department of Infectious Diseases, King's College London School of Medicine, London SE1 9RT, United Kingdom.

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May 2009

Alternative induced pluripotent stem cell characterization criteria for in vitro applications.

Cell Stem Cell 2009 Mar;4(3):198-9; author reply 202

ntario Human IPS Cell Facility, SickKids Research Institute, University of Toronto, Toronto, Ontario M5G 1L7, Canada.

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March 2009

Notch signaling respecifies the hemangioblast to a cardiac fate.

Nat Biotechnol 2008 Oct 28;26(10):1169-78. Epub 2008 Sep 28.

Department of Gene and Cell Medicine, The Black Family Stem Cell Institute, Mount Sinai School of Medicine, New York, New York 10029, USA.

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October 2008

Numb mediates the interaction between Wnt and Notch to modulate primitive erythropoietic specification from the hemangioblast.

Development 2008 Oct 17;135(20):3447-58. Epub 2008 Sep 17.

Department of Gene and Cell Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA.

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October 2008

Gene delivery by embryonic stem cells for malignant glioma therapy: hype or hope?

Cancer Biol Ther 2008 Sep 11;7(9):1341-7. Epub 2008 Sep 11.

Mount Sinai School of Medicine, Department of Neurosurgery, New York City, New York 10029, USA.

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September 2008

In vivo gene delivery by embryonic-stem-cell-derived astrocytes for malignant gliomas.

Neuro Oncol 2009 Apr 1;11(2):102-8. Epub 2008 Aug 1.

Department of neurosurgeruy, Mount Sinai School of Medicine, New York, NY 10029 USA.

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April 2009

Human cardiovascular progenitor cells develop from a KDR+ embryonic-stem-cell-derived population.

Nature 2008 May 23;453(7194):524-8. Epub 2008 Apr 23.

Department of Gene and Cell Medicine, The Black Family Stem Cell Institute, Mount Sinai School of Medicine, 1425 Madison Avenue, New York, New York 10029, USA.

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May 2008

Wnt, activin, and BMP signaling regulate distinct stages in the developmental pathway from embryonic stem cells to blood.

Cell Stem Cell 2008 Jan;2(1):60-71

McEwen Centre for Regenerative Medicine, University Health Network, Toronto, ON M5G 1L7, Canada.

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January 2008

Differentiation of embryonic stem cells to clinically relevant populations: lessons from embryonic development.

Cell 2008 Feb;132(4):661-80

Departments of Pathology and Bioengineering, Center for Cardiovascular Biology, Institute for Stem Cell and Regenerative Medicine, University of Washington, Seattle, WA 98109, USA.

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February 2008

Identification and targeting of the ROSA26 locus in human embryonic stem cells.

Nat Biotechnol 2007 Dec 25;25(12):1477-82. Epub 2007 Nov 25.

University Health Network, McEwen Centre for Regenerative Medicine, 101 College Street, Toronto, ON, M5G 1L7, Canada.

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December 2007