Publications by authors named "Gordon J Freeman"

100Publications

The PD-1 Pathway Regulates Development and Function of Memory CD8 T Cells following Respiratory Viral Infection.

Cell Rep 2020 Jun;31(13):107827

Department of Immunology, Blavatnik Institute, Harvard Medical School, and Evergrande Center for Immunologic Diseases, Harvard Medical School and Brigham and Women's Hospital, Boston, MA 02115, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Department of Pathology, Brigham and Women's Hospital, Boston, MA 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2020.107827DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7377452PMC
June 2020

The importance of exosomal PDL1 in tumour immune evasion.

Nat Rev Immunol 2020 04 21;20(4):209-215. Epub 2020 Jan 21.

Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1038/s41577-019-0264-yDOI Listing
April 2020

Acidity changes immunology: a new VISTA pathway.

Nat Immunol 2020 01;21(1):13-16

Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1038/s41590-019-0563-2DOI Listing
January 2020

The great debate at "Immunotherapy Bridge 2018", Naples, November 29th, 2018.

J Immunother Cancer 2019 08 15;7(1):221. Epub 2019 Aug 15.

Department of Medicine, Roswell Park Comprehensive Cancer Center, Developmental Therapeutics, Buffalo, New York, USA.

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http://dx.doi.org/10.1186/s40425-019-0683-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6696687PMC
August 2019

Intratumoral Activity of the CXCR3 Chemokine System Is Required for the Efficacy of Anti-PD-1 Therapy.

Immunity 2019 06 13;50(6):1498-1512.e5. Epub 2019 May 13.

Center for Immunology & Inflammatory Diseases, Division of Rheumatology, Allergy & Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA. Electronic address:

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http://dx.doi.org/10.1016/j.immuni.2019.04.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6527362PMC
June 2019

Blockade of RGMb inhibits allergen-induced airways disease.

J Allergy Clin Immunol 2019 07 29;144(1):94-108.e11. Epub 2019 Jan 29.

Boston Children's Hospital, Harvard Medical School, Boston, Mass; Sean N Parker Center for Allergy and Asthma Research, Department of Medicine, Stanford University, Stanford, Calif. Electronic address:

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http://dx.doi.org/10.1016/j.jaci.2018.12.1022DOI Listing
July 2019

Successful Anti-PD-1 Cancer Immunotherapy Requires T Cell-Dendritic Cell Crosstalk Involving the Cytokines IFN-γ and IL-12.

Immunity 2018 12 11;49(6):1148-1161.e7. Epub 2018 Dec 11.

Center for Systems Biology, Massachusetts General Hospital, 185 Cambridge St, CPZN 5206, Boston, MA 02114, USA; Department of Radiology, Massachusetts General Hospital, 185 Cambridge St, CPZN 5206, Boston, MA 02114, USA. Electronic address:

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http://dx.doi.org/10.1016/j.immuni.2018.09.024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6301092PMC
December 2018

PARP Inhibition Elicits STING-Dependent Antitumor Immunity in Brca1-Deficient Ovarian Cancer.

Cell Rep 2018 12;25(11):2972-2980.e5

Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S22111247183181
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http://dx.doi.org/10.1016/j.celrep.2018.11.054DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366450PMC
December 2018

Anti-PD-1/PD-L1 therapy augments lenvatinib's efficacy by favorably altering the immune microenvironment of murine anaplastic thyroid cancer.

Int J Cancer 2019 05 24;144(9):2266-2278. Epub 2019 Jan 24.

Department of Surgery, Division of General and Gastrointestinal Surgery, Harvard Medical School, Massachusetts General Hospital, Wang Ambulatory Care Center, 460, 15 Parkman Street, Boston, MA.

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http://dx.doi.org/10.1002/ijc.32041DOI Listing
May 2019

LSD1 Ablation Stimulates Anti-tumor Immunity and Enables Checkpoint Blockade.

Cell 2018 07 21;174(3):549-563.e19. Epub 2018 Jun 21.

Division of Newborn Medicine and Epigenetics Program, Boston Children's Hospital, Boston, MA 02115, USA; Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2018.05.052DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6063761PMC
July 2018

PD-L1 Binds to B7-1 Only on the Same Cell Surface.

Cancer Immunol Res 2018 08 5;6(8):921-929. Epub 2018 Jun 5.

Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts.

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http://cancerimmunolres.aacrjournals.org/lookup/doi/10.1158/
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http://dx.doi.org/10.1158/2326-6066.CIR-17-0316DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7394266PMC
August 2018

TSC2-deficient tumors have evidence of T cell exhaustion and respond to anti-PD-1/anti-CTLA-4 immunotherapy.

JCI Insight 2018 04 19;3(8). Epub 2018 Apr 19.

Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1172/jci.insight.98674DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5931128PMC
April 2018

Role of PD-1 during effector CD8 T cell differentiation.

Proc Natl Acad Sci U S A 2018 05 13;115(18):4749-4754. Epub 2018 Apr 13.

Emory Vaccine Center, Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA 30322;

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http://dx.doi.org/10.1073/pnas.1718217115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5939075PMC
May 2018

Modeling tumor immunity of mouse glioblastoma by exhausted CD8 T cells.

Sci Rep 2018 01 9;8(1):208. Epub 2018 Jan 9.

Harvey W. Cushing Neuro-oncology Laboratories (HCNL), Department of Neurosurgery, Harvard Medical School and Brigham and Women's Hospital, Boston, MA, 02115, USA.

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http://dx.doi.org/10.1038/s41598-017-18540-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5760520PMC
January 2018

Profiling of PD-1 Blockade Using Organotypic Tumor Spheroids.

Cancer Discov 2018 02 3;8(2):196-215. Epub 2017 Nov 3.

Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.

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http://dx.doi.org/10.1158/2159-8290.CD-17-0833DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5809290PMC
February 2018

Differential Expression of PD-L1 in High Grade T1 vs Muscle Invasive Bladder Carcinoma and its Prognostic Implications.

J Urol 2017 10 6;198(4):817-823. Epub 2017 May 6.

Bladder Cancer Center, Dana-Farber Cancer Institute/Brigham and Women's Cancer Center, Boston, Massachusetts; Harvard Medical School, Boston, Massachusetts. Electronic address:

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http://dx.doi.org/10.1016/j.juro.2017.04.102DOI Listing
October 2017

Expression of lectin-like transcript-1 in human tissues.

F1000Res 2016 29;5:2929. Epub 2016 Dec 29.

Peter Medawar Building for Pathogen Research, University of Oxford, Oxford, UK.

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http://dx.doi.org/10.12688/f1000research.10009.1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5365220PMC
December 2016

Aspirin Use and Colorectal Cancer Survival According to Tumor CD274 (Programmed Cell Death 1 Ligand 1) Expression Status.

J Clin Oncol 2017 Jun 13;35(16):1836-1844. Epub 2017 Apr 13.

Tsuyoshi Hamada, Zhi Rong Qian, Yohei Masugi, Juhong Yang, Kosuke Mima, Keisuke Kosumi, Li Liu, Yan Shi, Annacarolina da Silva, Mancang Gu, Wanwan Li, Jeffrey A. Meyerhardt, Marios Giannakis, Scott J. Rodig, Gordon J. Freeman, Charles S. Fuchs, Reiko Nishihara, and Shuji Ogino, Dana-Farber Cancer Institute and Harvard Medical School; Yin Cao, Mingyang Song, and Andrew T. Chan, Massachusetts General Hospital and Harvard Medical School; Yin Cao, Mingyang Song, Li Liu, NaNa Keum, Kana Wu, Edward L. Giovannucci, Daniel Nevo, Molin Wang, Reiko Nishihara, and Shuji Ogino, Harvard T.H. Chan School of Public Health; Jonathan A. Nowak, Xuehong Zhang, Edward L. Giovannucci, Marios Giannakis, Gordon J. Freeman, Molin Wang, Andrew T. Chan, Charles S. Fuchs, and Shuji Ogino, Brigham and Women's Hospital and Harvard Medical School, Boston; Marios Giannakis and Andrew T. Chan, Broad Institute of MIT and Harvard University, Cambridge, MA; Li Liu, Huazhong University of Science and Technology, Wuhan; Yan Shi, Chinese People's Liberation Army General Hospital, Beijing; and Mancang Gu, Zhejiang Chinese Medical University, Hangzhou, People's Republic of China.

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http://dx.doi.org/10.1200/JCO.2016.70.7547DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5455595PMC
June 2017

Loss of PTEN Is Associated with Resistance to Anti-PD-1 Checkpoint Blockade Therapy in Metastatic Uterine Leiomyosarcoma.

Immunity 2017 02;46(2):197-204

Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Center for Cancer Precision Medicine, Dana-Farber Cancer Institute, Boston, MA 02215, USA. Electronic address:

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http://dx.doi.org/10.1016/j.immuni.2017.02.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5408320PMC
February 2017

Defining CD8+ T cells that provide the proliferative burst after PD-1 therapy.

Nature 2016 09 2;537(7620):417-421. Epub 2016 Aug 2.

Emory Vaccine Center and Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, Georgia 30322, USA.

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http://dx.doi.org/10.1038/nature19330DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5297183PMC
September 2016

Immune Profiling of Adenoid Cystic Carcinoma: PD-L2 Expression and Associations with Tumor-Infiltrating Lymphocytes.

Cancer Immunol Res 2016 08 16;4(8):679-87. Epub 2016 Jun 16.

Department of Radiation Oncology, Brigham and Women's Hospital/Dana-Farber Cancer Center, Boston, Massachusetts.

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http://dx.doi.org/10.1158/2326-6066.CIR-16-0031DOI Listing
August 2016

Nivolumab in Patients With Relapsed or Refractory Hematologic Malignancy: Preliminary Results of a Phase Ib Study.

J Clin Oncol 2016 08 6;34(23):2698-704. Epub 2016 Jun 6.

Alexander M. Lesokhin and Deepika Cattry, Memorial Sloan Kettering Cancer Center; Alexander M. Lesokhin, Weill Cornell Medical College, New York, NY; Stephen M. Ansell, Mayo Clinic, Rochester, MN; Philippe Armand, Bjoern Chapuy, Gordon J. Freeman, Scott J. Rodig, and Margaret A. Shipp, Dana-Farber Cancer Institute; David Avigan, Beth Israel Deaconess Medical Center; Azra H. Ligon and Scott J. Rodig, Brigham and Women's Hospital, Boston, MA; Emma C. Scott, Oregon Health & Science University Knight Cancer Institute, Portland, OR; Ahmad Halwani, University of Utah Huntsman Cancer Institute, Salt Lake City, UT; Martin Gutierrez, Hackensack University Medical Center, Hackensack; Lili Zhu, Joseph F. Grosso, and M. Brigid Bradley Garelik, Bristol-Myers Squibb, Princeton, NJ; Michael M. Millenson, Fox Chase Cancer Center; Adam D. Cohen and Stephen J. Schuster, University of Pennsylvania, Philadelphia, PA; Daniel Lebovic, University of Michigan, Ann Arbor, MI; Madhav Dhodapkar, Yale Cancer Center, New Haven, CT; Ivan Borrello, Johns Hopkins University School of Medicine, Baltimore, MD; and John Timmerman, University of California, Los Angeles, CA.

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http://dx.doi.org/10.1200/JCO.2015.65.9789DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5019749PMC
August 2016

Coinhibitory Pathways in the B7-CD28 Ligand-Receptor Family.

Immunity 2016 05;44(5):955-72

Department of Microbiology and Immunobiology, and Evergrande Center for Immunologic Diseases, Harvard Medical School, Boston, MA 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.immuni.2016.05.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905708PMC
May 2016

Learning from PD-1 Resistance: New Combination Strategies.

Trends Mol Med 2016 06 9;22(6):448-451. Epub 2016 May 9.

Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molmed.2016.04.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6833952PMC
June 2016

PD-L1 and PD-L2 Genetic Alterations Define Classical Hodgkin Lymphoma and Predict Outcome.

J Clin Oncol 2016 08 11;34(23):2690-7. Epub 2016 Apr 11.

Margaretha G.M. Roemer, Robert A. Redd, Heather Homer, Courtney F. Connelly, Gordon J. Freeman, Philippe Armand, Bjoern Chapuy, Donna S. Neuberg, and Margaret A. Shipp, Dana-Farber Cancer Institute; Azra H. Ligon, Heather H. Sun, and Scott J. Rodig, Brigham and Women's Hospital, Boston, MA; Margaretha G.M. Roemer and Daphne de Jong, VU University Medical Center, Amsterdam, the Netherlands; and Ranjana H. Advani, Yasodha Natkunam, Sarah E. Daadi, and Richard T. Hoppe, Stanford University Medical Center, Stanford, CA.

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http://dx.doi.org/10.1200/JCO.2016.66.4482DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5019753PMC
August 2016

Coinhibitory Pathways in Immunotherapy for Cancer.

Annu Rev Immunol 2016 05 25;34:539-73. Epub 2016 Feb 25.

Department of Microbiology and Immunobiology, and Evergrande Center for Immunologic Diseases, Harvard Medical School, Boston, Massachusetts 02115; email:

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http://dx.doi.org/10.1146/annurev-immunol-032414-112049DOI Listing
May 2016

Repulsive Guidance Molecule b (RGMb) Is Dispensable for Normal Gonadal Function in Mice.

Biol Reprod 2016 Apr 24;94(4):78. Epub 2016 Feb 24.

Key Laboratory for Regenerative Medicine, Ministry of Education, School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China School of Biomedical Sciences Core Laboratory, The Chinese University of Hong Kong Shenzhen Research Institute, Shenzhen, China

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http://dx.doi.org/10.1095/biolreprod.115.135921DOI Listing
April 2016

LLT1 and CD161 Expression in Human Germinal Centers Promotes B Cell Activation and CXCR4 Downregulation.

J Immunol 2016 Mar 1;196(5):2085-94. Epub 2016 Feb 1.

Peter Medawar Building for Pathogen Research, University of Oxford, Oxford OX1 3SY, United Kindgom; Oxford National Institute for Health Research Biomedical Research Centre, Oxford OX3 9DU, United Kingdom

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http://www.jimmunol.org/lookup/doi/10.4049/jimmunol.1502462
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http://dx.doi.org/10.4049/jimmunol.1502462DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4760235PMC
March 2016

Blockade of Tim-1 and Tim-4 Enhances Atherosclerosis in Low-Density Lipoprotein Receptor-Deficient Mice.

Arterioscler Thromb Vasc Biol 2016 Mar 28;36(3):456-65. Epub 2016 Jan 28.

From the Department of Pathology (A.C.F., D.E., F.K., N.A.-G., P.J., A.H.L.) and Department of Surgery (J.L.), Harvard Medical School, Brigham and Women's Hospital, Boston, MA; Department of Medicine, University of California, San Diego, La Jolla (A.G., J.L.W.); Department of Medicine, Stanford University, Stanford, CA (R.H.D.); and Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA (G.J.F.).

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http://atvb.ahajournals.org/content/early/2016/01/28/ATVBAHA
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http://atvb.ahajournals.org/lookup/doi/10.1161/ATVBAHA.115.3
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http://dx.doi.org/10.1161/ATVBAHA.115.306860DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4853762PMC
March 2016

Expression of Programmed Cell Death 1 Ligands (PD-L1 and PD-L2) in Histiocytic and Dendritic Cell Disorders.

Am J Surg Pathol 2016 Apr;40(4):443-53

*Department of Pathology, Brigham and Women's Hospital Departments of †Medical Oncology ‡Immuno-Oncology, Dana-Farber Cancer Institute, Boston, MA.

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http://dx.doi.org/10.1097/PAS.0000000000000590DOI Listing
April 2016