Gordon Dougan

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Gordon Dougan

Publications by authors named "Gordon Dougan"

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100Publications

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Laboratory and molecular surveillance of paediatric typhoidal Salmonella in Nepal: Antimicrobial resistance and implications for vaccine policy.

PLoS Negl Trop Dis 2018 04 23;12(4):e0006408. Epub 2018 Apr 23.

Oxford Vaccine Group, Department of Paediatrics, University of Oxford and the NIHR Oxford Biomedical Research Centre, Oxford, United Kingdom.

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April 2018

Comparison of Salmonella enterica Serovars Typhi and Typhimurium Reveals Typhoidal Serovar-Specific Responses to Bile.

Infect Immun 2018 Mar 20;86(3). Epub 2018 Feb 20.

MRC Centre for Molecular Bacteriology and Infection, Department of Life Sciences, Imperial College London, London, United Kingdom

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March 2018

PlasmidTron: assembling the cause of phenotypes and genotypes from NGS data.

Microb Genom 2018 Mar 12. Epub 2018 Mar 12.

1​Infection Genomics, Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK.

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March 2018

Outer membrane vesicles from Neisseria gonorrhoeae target PorB to mitochondria and induce apoptosis.

PLoS Pathog 2018 03 30;14(3):e1006945. Epub 2018 Mar 30.

Biomedicine Discovery Institute and Department of Biochemistry & Molecular Biology, Monash University, Clayton, Victoria, Australia.

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March 2018

Constraints on lateral gene transfer in promoting fimbrial usher protein diversity and function.

Open Biol 2017 Nov;7(11)

Infection Genomics Program, Wellcome Trust Sanger Institute, Hinxton CB10 1SA, UK

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November 2017

Identification and characterization of the novel colonization factor CS30 based on whole genome sequencing in enterotoxigenic Escherichia coli (ETEC).

Sci Rep 2017 Oct 2;7(1):12514. Epub 2017 Oct 2.

Department of Microbiology and Immunology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.

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October 2017

Preterm Infant-Associated Clostridium tertium, Clostridium cadaveris, and Clostridium paraputrificum Strains: Genomic and Evolutionary Insights.

Genome Biol Evol 2017 10;9(10):2707-2714

The Gut Health and Food Safety Programme, Quadram Institute Bioscience, Norwich Research Park, Norwich, United Kingdom.

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October 2017

Complete Genome Sequence of Serotype III Sequence Type 17 Strain 874391.

Genome Announc 2017 Oct 19;5(42). Epub 2017 Oct 19.

School of Medical Science, and Menzies Health Institute Queensland, Griffith University, Gold Coast, Australia

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October 2017

Induction of Cell Cycle and NK Cell Responses by Live-Attenuated Oral Vaccines against Typhoid Fever.

Front Immunol 2017 12;8:1276. Epub 2017 Oct 12.

Oxford Vaccine Group, Department of Paediatrics, University of Oxford, NIHR Oxford Biomedical Research Centre, Oxford, United Kingdom.

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October 2017

An evaluation of purified Salmonella Typhi protein antigens for the serological diagnosis of acute typhoid fever.

J Infect 2017 Aug 25;75(2):104-114. Epub 2017 May 25.

The Hospital for Tropical Diseases, Wellcome Trust Major Overseas Programme, Oxford University Clinical Research Unit, Ho Chi Minh City, Viet Nam; Centre for Tropical Medicine and Global Health, Oxford University, Oxford, United Kingdom; The Department of Medicine, University of Cambridge, Cambridge, United Kingdom. Electronic address:

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August 2017

Hyperactivation of HUSH complex function by Charcot-Marie-Tooth disease mutation in MORC2.

Nat Genet 2017 Jul 5;49(7):1035-1044. Epub 2017 Jun 5.

Department of Medicine, Cambridge Institute for Medical Research, Cambridge Biomedical Campus, Cambridge, CB2 0XY, UK.

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July 2017

Typhoid in Africa and vaccine deployment.

Authors:
Gordon Dougan

Lancet Glob Health 2017 03;5(3):e236-e237

The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SA, UK; Department of Medicine, University of Cambridge, Addenbrooke's Hospital, Cambridge, UK. Electronic address:

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March 2017

The Type III Secretion System Effector SptP of Salmonella enterica Serovar Typhi.

J Bacteriol 2017 02 30;199(4). Epub 2017 Jan 30.

MRC Centre for Molecular Bacteriology and Infection, Department of Life Sciences, Imperial College London, London, United Kingdom

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February 2017

Mitochondrial Protein Lipoylation and the 2-Oxoglutarate Dehydrogenase Complex Controls HIF1α Stability in Aerobic Conditions.

Cell Metab 2016 Nov 27;24(5):740-752. Epub 2016 Oct 27.

Department of Medicine, Cambridge Institute for Medical Research, University of Cambridge, Cambridge, CB2 0XY, UK. Electronic address:

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November 2016

Retrospective Analysis of Serotype Switching of Vibrio cholerae O1 in a Cholera Endemic Region Shows It Is a Non-random Process.

PLoS Negl Trop Dis 2016 Oct 5;10(10):e0005044. Epub 2016 Oct 5.

Department of Microbiology and Immunology, Institute of Biomedicine, University of Gothenburg, Gothenburg, Sweden.

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October 2016

ATF7IP-Mediated Stabilization of the Histone Methyltransferase SETDB1 Is Essential for Heterochromatin Formation by the HUSH Complex.

Cell Rep 2016 10;17(3):653-659

Department of Medicine, Cambridge Institute for Medical Research, Cambridge Biomedical Campus, Cambridge CB2 0XY, UK. Electronic address:

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October 2016

Derivation of Intestinal Organoids from Human Induced Pluripotent Stem Cells for Use as an Infection System.

Methods Mol Biol 2016 Aug 31. Epub 2016 Aug 31.

Wellcome Trust Sanger Institute, Hinxton, Cambridge, UK.

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August 2016

Conserved Features in the Structure, Mechanism, and Biogenesis of the Inverse Autotransporter Protein Family.

Genome Biol Evol 2016 06 13;8(6):1690-705. Epub 2016 Jun 13.

Department of Microbiology, Infection & Immunity Program, Biomedicine Discovery Institute, Monash University, Clayton, Australia

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June 2016

Genetic dissection of mammalian ERAD through comparative haploid and CRISPR forward genetic screens.

Nat Commun 2016 Jun 10;7:11786. Epub 2016 Jun 10.

Department of Medicine, Cambridge Institute for Medical Research, Cambridge Biomedical Campus, Hills Road, Cambridge CB2 0XY, UK.

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June 2016

The Molecular and Spatial Epidemiology of Typhoid Fever in Rural Cambodia.

PLoS Negl Trop Dis 2016 06 22;10(6):e0004785. Epub 2016 Jun 22.

The Hospital for Tropical Diseases, Wellcome Trust Major Overseas Programme, Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam.

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June 2016

Advances in Understanding Bacterial Pathogenesis Gained from Whole-Genome Sequencing and Phylogenetics.

Cell Host Microbe 2016 May;19(5):599-610

Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK. Electronic address:

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May 2016

T cell fate and clonality inference from single-cell transcriptomes.

Nat Methods 2016 Apr 7;13(4):329-332. Epub 2016 Mar 7.

European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Cambridge, UK.

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April 2016

Induced pluripotent stem cell derived macrophages as a cellular system to study salmonella and other pathogens.

PLoS One 2015 6;10(5):e0124307. Epub 2015 May 6.

Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, United Kingdom; Kennedy Institute of Rheumatology, University of Oxford, Oxford, United Kingdom.

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February 2016

Five decades of genome evolution in the globally distributed, extensively antibiotic-resistant global clone 1.

Microb Genom 2016 Feb 23;2(2):e000052. Epub 2016 Feb 23.

School of Molecular Bioscience, The University of Sydney , Sydney, New South Wales , Australia.

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February 2016

Discovery and Characterization of Human-Urine Utilization by Asymptomatic-Bacteriuria-Causing Streptococcus agalactiae.

Infect Immun 2016 01 9;84(1):307-19. Epub 2015 Nov 9.

School of Medical Sciences, Menzies Health Institute Queensland, Griffith University, Gold Coast Campus, QLD, Australia Department of Microbiology, University of Alabama at Birmingham, Birmingham, Alabama, USA

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January 2016

Transfer of scarlet fever-associated elements into the group A Streptococcus M1T1 clone.

Sci Rep 2015 Nov 2;5:15877. Epub 2015 Nov 2.

Australian Infectious Diseases Research Centre, School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, QLD 4072, Australia.

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November 2015

Non-typhoidal Salmonella Typhimurium ST313 isolates that cause bacteremia in humans stimulate less inflammasome activation than ST19 isolates associated with gastroenteritis.

Pathog Dis 2015 Jun 24;73(4). Epub 2014 Dec 24.

Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA

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June 2015

GENE SILENCING. Epigenetic silencing by the HUSH complex mediates position-effect variegation in human cells.

Science 2015 Jun 28;348(6242):1481-1485. Epub 2015 May 28.

Department of Medicine, Cambridge Institute for Medical Research, Addenbrooke's Hospital, Hills Road, Cambridge, CB2 0XY, UK.

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June 2015

Oral Wild-Type Salmonella Typhi Challenge Induces Activation of Circulating Monocytes and Dendritic Cells in Individuals Who Develop Typhoid Disease.

PLoS Negl Trop Dis 2015 Jun 11;9(6):e0003837. Epub 2015 Jun 11.

Center for Vaccine Development, University of Maryland School of Medicine, Baltimore, Maryland, United States of America; Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland, United States of America; Department of Pediatrics, University of Maryland School of Medicine, Baltimore, Maryland, United States of America.

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June 2015

Salmonella enterica serovar Typhi and the pathogenesis of typhoid fever.

Annu Rev Microbiol 2014 ;68:317-36

The Wellcome Trust Sanger Institute, The Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, United Kingdom; email:

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May 2015

Activation of Salmonella Typhi-specific regulatory T cells in typhoid disease in a wild-type S. Typhi challenge model.

PLoS Pathog 2015 May 22;11(5):e1004914. Epub 2015 May 22.

Center for Vaccine Development, University of Maryland School of Medicine, Baltimore, Maryland, United States of America.

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May 2015

Rapid emergence of multidrug resistant, H58-lineage Salmonella typhi in Blantyre, Malawi.

PLoS Negl Trop Dis 2015 Apr 24;9(4):e0003748. Epub 2015 Apr 24.

Malawi Liverpool Wellcome Trust Clinical Research Programme, University of Malawi College of Medicine, Blantyre, Malawi; Liverpool School of Tropical Medicine, Liverpool, United Kingdom.

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April 2015

Insertions in the OCL1 locus of Acinetobacter baumannii lead to shortened lipooligosaccharides.

Res Microbiol 2014 Jul-Aug;165(6):472-5. Epub 2014 May 23.

School of Molecular Bioscience, The University of Sydney, New South Wales, Australia. Electronic address:

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March 2015

Signatures of adaptation in human invasive Salmonella Typhimurium ST313 populations from sub-Saharan Africa.

PLoS Negl Trop Dis 2015 Mar 24;9(3):e0003611. Epub 2015 Mar 24.

Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, United Kingdom; Institute of Food Research, Norwich Research Park, Norwich, Norfolk, United Kingdom.

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March 2015

Emergence of scarlet fever Streptococcus pyogenes emm12 clones in Hong Kong is associated with toxin acquisition and multidrug resistance.

Nat Genet 2015 Jan 17;47(1):84-7. Epub 2014 Nov 17.

Australian Infectious Diseases Research Centre, School of Chemistry and Molecular Biosciences, University of Queensland, St. Lucia, Queensland, Australia.

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January 2015

Allele variants of enterotoxigenic Escherichia coli heat-labile toxin are globally transmitted and associated with colonization factors.

J Bacteriol 2015 Jan 17;197(2):392-403. Epub 2014 Nov 17.

Department of Microbiology and Immunology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden

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January 2015

The Hd, Hj, and Hz66 flagella variants of Salmonella enterica serovar Typhi modify host responses and cellular interactions.

Sci Rep 2015 Jan 22;5:7947. Epub 2015 Jan 22.

1] The Hospital for Tropical Diseases, Wellcome Trust Major Overseas Programme, Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam [2] Centre for Tropical Medicine, Nuffield Department of Clinical Medicine, Oxford University, United Kingdom [3] The London School of Hygiene and Tropical Medicine, London, United Kingdom.

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January 2015

Typhoid fever in Fiji: a reversible plague?

Trop Med Int Health 2014 Oct 25;19(10):1284-92. Epub 2014 Jul 25.

Hospital for Tropical Diseases, Wellcome Trust Major Overseas Programme, Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam; Centre for Tropical Medicine, Nuffield Department of Clinical Medicine, Oxford University, Oxford, UK.

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October 2014

CD28 expression is required after T cell priming for helper T cell responses and protective immunity to infection.

Elife 2014 Oct 27;3. Epub 2014 Oct 27.

Cambridge Institute for Medical Research, University of Cambridge School of Clinical Medicine, Cambridge, United Kingdom.

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October 2014

TMEM129 is a Derlin-1 associated ERAD E3 ligase essential for virus-induced degradation of MHC-I.

Proc Natl Acad Sci U S A 2014 Aug 16;111(31):11425-30. Epub 2014 Jul 16.

Cambridge Institute for Medical Research, Department of Medicine, University of Cambridge, Cambridge CB2 0XY, United Kingdom;

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August 2014

Transient Darwinian selection in Salmonella enterica serovar Paratyphi A during 450 years of global spread of enteric fever.

Proc Natl Acad Sci U S A 2014 Aug 4;111(33):12199-204. Epub 2014 Aug 4.

Warwick Medical School, University of Warwick, Coventry CV4 7AL, United Kingdom;Environmental Research Institute and Department of Microbiology, University College Cork, Cork, Ireland;

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August 2014

The population structure of Vibrio cholerae from the Chandigarh Region of Northern India.

PLoS Negl Trop Dis 2014 Jul 24;8(7):e2981. Epub 2014 Jul 24.

Pathogen Genomics Laboratory, Computational Bioscience Research Center, King Abdullah University of Science and Technology (KAUST), Thuwal, Kingdom of Saudi Arabia.

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July 2014

Complete Genome Sequences of Two Citrobacter rodentium Bacteriophages, CR8 and CR44b.

Genome Announc 2014 May 29;2(3). Epub 2014 May 29.

The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire, United Kingdom.

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May 2014