Gordon Dougan

Gordon Dougan

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Gordon Dougan

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Genome-Wide Epigenetic and Transcriptomic Characterization of Human-Induced Pluripotent Stem Cell-Derived Intestinal Epithelial Organoids.

Cell Mol Gastroenterol Hepatol 2019 23;7(2):285-288. Epub 2018 Oct 23.

Department of Pediatrics, University of Cambridge, Cambridge, United Kingdom; Department of Pediatric Gastroenterology, Hepatology and Nutrition, Addenbrooke's Hospital, Cambridge, United Kingdom; Wellcome Trust-Medical Research Council Stem Cell Institute, University of Cambridge, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/j.jcmgh.2018.10.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354438PMC
May 2019

Using Human Induced Pluripotent Stem Cell-derived Intestinal Organoids to Study and Modify Epithelial Cell Protection Against Salmonella and Other Pathogens.

J Vis Exp 2019 May 12(147). Epub 2019 May 12.

Wellcome Trust Sanger Institute; Department of Medicine, University of Cambridge.

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http://dx.doi.org/10.3791/59478DOI Listing
May 2019

Antibiotic Resistance and Typhoid.

Clin Infect Dis 2019 Mar;68(Supplement_2):S165-S170

Department of Medicine, University of Cambridge, Hinxton, Cambridge, United Kingdom.

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http://dx.doi.org/10.1093/cid/ciy1111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6405283PMC
March 2019

Using a Systems Biology Approach To Study Host-Pathogen Interactions.

Microbiol Spectr 2019 03;7(2)

Department of Medicine, University of Cambridge, Addenbrooke's Hospital, Cambridge CB2 0QQ, United Kingdom.

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http://dx.doi.org/10.1128/microbiolspec.BAI-0021-2019DOI Listing
March 2019

Meeting the discovery challenge of drug-resistant infections: progress and focusing resources.

Drug Discov Today 2019 02 23;24(2):452-461. Epub 2018 Nov 23.

Medicine Discovery Catapult, Mereside, Alderly Park, Alderly Edge, Cheshire, UK.

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https://linkinghub.elsevier.com/retrieve/pii/S13596446183023
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http://dx.doi.org/10.1016/j.drudis.2018.11.015DOI Listing
February 2019

Detection of epidemic scarlet fever group A Streptococcus in Australia.

Clin Infect Dis 2019 Feb 5. Epub 2019 Feb 5.

Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Melbourne, VIC, Australia.

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http://dx.doi.org/10.1093/cid/ciz099DOI Listing
February 2019

Resistance mechanisms and population structure of highly drug resistant Klebsiella in Pakistan during the introduction of the carbapenemase NDM-1.

Sci Rep 2019 Feb 20;9(1):2392. Epub 2019 Feb 20.

Department of Microbiology and Immunology, The University of Melbourne, at Peter Doherty Institute for Infection and Immunity, Melbourne, Australia.

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http://dx.doi.org/10.1038/s41598-019-38943-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6382945PMC
February 2019

Emergence of dominant multidrug-resistant bacterial clades: Lessons from history and whole-genome sequencing.

Proc Natl Acad Sci U S A 2018 12;115(51):12872-12877

Infection Genomics Programme, Wellcome Trust Sanger Institute, CB10 1SA Cambridge, United Kingdom;

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http://dx.doi.org/10.1073/pnas.1717162115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6304985PMC
December 2018

The phylogeography and incidence of multi-drug resistant typhoid fever in sub-Saharan Africa.

Nat Commun 2018 11 30;9(1):5094. Epub 2018 Nov 30.

The Hospital for Tropical Diseases, Wellcome Trust Major Overseas Programme, Oxford University Clinical Research Unit, 764 Vo Van Kiet, Quant 5, Ho Chi Minh City, Vietnam.

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http://www.nature.com/articles/s41467-018-07370-z
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http://dx.doi.org/10.1038/s41467-018-07370-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6269545PMC
November 2018

Identification of novel adenovirus genotype 90 in children from Bangladesh.

Microb Genom 2018 10 24;4(10). Epub 2018 Sep 24.

1​Department of Medicine, University of Cambridge, Cambridge, UK.

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http://dx.doi.org/10.1099/mgen.0.000221DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6249435PMC
October 2018

An investigation into the Omp85 protein BamK in hypervirulent Klebsiella pneumoniae, and its role in outer membrane biogenesis.

Mol Microbiol 2018 09 19;109(5):584-599. Epub 2018 Sep 19.

Infection & Immunity Program, Biomedicine Discovery Institute and Department of Microbiology, Monash University, Clayton, 3800, Australia.

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http://dx.doi.org/10.1111/mmi.13990DOI Listing
September 2018

FusC, a member of the M16 protease family acquired by bacteria for iron piracy against plants.

PLoS Biol 2018 08 2;16(8):e2006026. Epub 2018 Aug 2.

Infection and Immunity Program, Biomedicine Discovery Institute and Department of Microbiology, Monash University, Clayton, Australia.

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http://dx.doi.org/10.1371/journal.pbio.2006026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6071955PMC
August 2018

Comparison of Salmonella enterica Serovars Typhi and Typhimurium Reveals Typhoidal Serovar-Specific Responses to Bile.

Infect Immun 2018 03 20;86(3). Epub 2018 Feb 20.

MRC Centre for Molecular Bacteriology and Infection, Department of Life Sciences, Imperial College London, London, United Kingdom

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http://dx.doi.org/10.1128/IAI.00490-17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5820949PMC
March 2018

PlasmidTron: assembling the cause of phenotypes and genotypes from NGS data.

Microb Genom 2018 Mar 12;4(3). Epub 2018 Mar 12.

1​Infection Genomics, Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK.

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http://dx.doi.org/10.1099/mgen.0.000164DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5885016PMC
March 2018

Outer membrane vesicles from Neisseria gonorrhoeae target PorB to mitochondria and induce apoptosis.

PLoS Pathog 2018 03 30;14(3):e1006945. Epub 2018 Mar 30.

Biomedicine Discovery Institute and Department of Biochemistry & Molecular Biology, Monash University, Clayton, Victoria, Australia.

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http://dx.doi.org/10.1371/journal.ppat.1006945DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5877877PMC
March 2018

Constraints on lateral gene transfer in promoting fimbrial usher protein diversity and function.

Open Biol 2017 11;7(11)

Infection Genomics Program, Wellcome Trust Sanger Institute, Hinxton CB10 1SA, UK

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http://dx.doi.org/10.1098/rsob.170144DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5717340PMC
November 2017

Preterm Infant-Associated Clostridium tertium, Clostridium cadaveris, and Clostridium paraputrificum Strains: Genomic and Evolutionary Insights.

Genome Biol Evol 2017 10;9(10):2707-2714

The Gut Health and Food Safety Programme, Quadram Institute Bioscience, Norwich Research Park, Norwich, United Kingdom.

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http://dx.doi.org/10.1093/gbe/evx210DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5647805PMC
October 2017

Complete Genome Sequence of Serotype III Sequence Type 17 Strain 874391.

Genome Announc 2017 Oct 19;5(42). Epub 2017 Oct 19.

School of Medical Science, and Menzies Health Institute Queensland, Griffith University, Gold Coast, Australia

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http://dx.doi.org/10.1128/genomeA.01107-17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5646402PMC
October 2017

Induction of Cell Cycle and NK Cell Responses by Live-Attenuated Oral Vaccines against Typhoid Fever.

Front Immunol 2017 12;8:1276. Epub 2017 Oct 12.

Oxford Vaccine Group, Department of Paediatrics, University of Oxford, NIHR Oxford Biomedical Research Centre, Oxford, United Kingdom.

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http://dx.doi.org/10.3389/fimmu.2017.01276DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5643418PMC
October 2017

An evaluation of purified Salmonella Typhi protein antigens for the serological diagnosis of acute typhoid fever.

J Infect 2017 08 25;75(2):104-114. Epub 2017 May 25.

The Hospital for Tropical Diseases, Wellcome Trust Major Overseas Programme, Oxford University Clinical Research Unit, Ho Chi Minh City, Viet Nam; Centre for Tropical Medicine and Global Health, Oxford University, Oxford, United Kingdom; The Department of Medicine, University of Cambridge, Cambridge, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/j.jinf.2017.05.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5522525PMC
August 2017

Hyperactivation of HUSH complex function by Charcot-Marie-Tooth disease mutation in MORC2.

Nat Genet 2017 Jul 5;49(7):1035-1044. Epub 2017 Jun 5.

Department of Medicine, Cambridge Institute for Medical Research, Cambridge Biomedical Campus, Cambridge, CB2 0XY, UK.

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http://dx.doi.org/10.1038/ng.3878DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5493197PMC
July 2017

Typhoid in Africa and vaccine deployment.

Authors:
Gordon Dougan

Lancet Glob Health 2017 03;5(3):e236-e237

The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SA, UK; Department of Medicine, University of Cambridge, Addenbrooke's Hospital, Cambridge, UK. Electronic address:

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http://dx.doi.org/10.1016/S2214-109X(17)30045-1DOI Listing
March 2017

The Type III Secretion System Effector SptP of Salmonella enterica Serovar Typhi.

J Bacteriol 2017 02 30;199(4). Epub 2017 Jan 30.

MRC Centre for Molecular Bacteriology and Infection, Department of Life Sciences, Imperial College London, London, United Kingdom

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http://dx.doi.org/10.1128/JB.00647-16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5287405PMC
February 2017

Mitochondrial Protein Lipoylation and the 2-Oxoglutarate Dehydrogenase Complex Controls HIF1α Stability in Aerobic Conditions.

Cell Metab 2016 11 27;24(5):740-752. Epub 2016 Oct 27.

Department of Medicine, Cambridge Institute for Medical Research, University of Cambridge, Cambridge, CB2 0XY, UK. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2016.09.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5106373PMC
November 2016

Retrospective Analysis of Serotype Switching of Vibrio cholerae O1 in a Cholera Endemic Region Shows It Is a Non-random Process.

PLoS Negl Trop Dis 2016 Oct 5;10(10):e0005044. Epub 2016 Oct 5.

Department of Microbiology and Immunology, Institute of Biomedicine, University of Gothenburg, Gothenburg, Sweden.

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http://dx.doi.org/10.1371/journal.pntd.0005044DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5051702PMC
October 2016

ATF7IP-Mediated Stabilization of the Histone Methyltransferase SETDB1 Is Essential for Heterochromatin Formation by the HUSH Complex.

Cell Rep 2016 10;17(3):653-659

Department of Medicine, Cambridge Institute for Medical Research, Cambridge Biomedical Campus, Cambridge CB2 0XY, UK. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2016.09.050DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5081395PMC
October 2016

Derivation of Intestinal Organoids from Human Induced Pluripotent Stem Cells for Use as an Infection System.

Methods Mol Biol 2016 Aug 31. Epub 2016 Aug 31.

Wellcome Trust Sanger Institute, Hinxton, Cambridge, UK.

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http://dx.doi.org/10.1007/7651_2016_7DOI Listing
August 2016

Conserved Features in the Structure, Mechanism, and Biogenesis of the Inverse Autotransporter Protein Family.

Genome Biol Evol 2016 06 13;8(6):1690-705. Epub 2016 Jun 13.

Department of Microbiology, Infection & Immunity Program, Biomedicine Discovery Institute, Monash University, Clayton, Australia

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http://dx.doi.org/10.1093/gbe/evw112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4943183PMC
June 2016

Genetic dissection of mammalian ERAD through comparative haploid and CRISPR forward genetic screens.

Nat Commun 2016 06 10;7:11786. Epub 2016 Jun 10.

Department of Medicine, Cambridge Institute for Medical Research, Cambridge Biomedical Campus, Hills Road, Cambridge CB2 0XY, UK.

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http://dx.doi.org/10.1038/ncomms11786DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4906395PMC
June 2016

The Molecular and Spatial Epidemiology of Typhoid Fever in Rural Cambodia.

PLoS Negl Trop Dis 2016 06 22;10(6):e0004785. Epub 2016 Jun 22.

The Hospital for Tropical Diseases, Wellcome Trust Major Overseas Programme, Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam.

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http://dx.doi.org/10.1371/journal.pntd.0004785DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4917249PMC
June 2016

Advances in Understanding Bacterial Pathogenesis Gained from Whole-Genome Sequencing and Phylogenetics.

Cell Host Microbe 2016 May;19(5):599-610

Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK. Electronic address:

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http://dx.doi.org/10.1016/j.chom.2016.04.015DOI Listing
May 2016

T cell fate and clonality inference from single-cell transcriptomes.

Nat Methods 2016 Apr 7;13(4):329-332. Epub 2016 Mar 7.

European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Cambridge, UK.

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http://dx.doi.org/10.1038/nmeth.3800DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4835021PMC
April 2016

Five decades of genome evolution in the globally distributed, extensively antibiotic-resistant global clone 1.

Microb Genom 2016 02 23;2(2):e000052. Epub 2016 Feb 23.

3​ School of Molecular Bioscience, The University of Sydney, Sydney, New South Wales, Australia.

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http://dx.doi.org/10.1099/mgen.0.000052DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5320584PMC
February 2016

Discovery and Characterization of Human-Urine Utilization by Asymptomatic-Bacteriuria-Causing Streptococcus agalactiae.

Infect Immun 2016 01 9;84(1):307-19. Epub 2015 Nov 9.

School of Medical Sciences, Menzies Health Institute Queensland, Griffith University, Gold Coast Campus, QLD, Australia Department of Microbiology, University of Alabama at Birmingham, Birmingham, Alabama, USA

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http://dx.doi.org/10.1128/IAI.00938-15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4694007PMC
January 2016

Transfer of scarlet fever-associated elements into the group A Streptococcus M1T1 clone.

Sci Rep 2015 Nov 2;5:15877. Epub 2015 Nov 2.

Australian Infectious Diseases Research Centre, School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, QLD 4072, Australia.

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http://dx.doi.org/10.1038/srep15877DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4629146PMC
November 2015

GENE SILENCING. Epigenetic silencing by the HUSH complex mediates position-effect variegation in human cells.

Science 2015 Jun 28;348(6242):1481-1485. Epub 2015 May 28.

Department of Medicine, Cambridge Institute for Medical Research, Addenbrooke's Hospital, Hills Road, Cambridge, CB2 0XY, UK.

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http://dx.doi.org/10.1126/science.aaa7227DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4487827PMC
June 2015

Oral Wild-Type Salmonella Typhi Challenge Induces Activation of Circulating Monocytes and Dendritic Cells in Individuals Who Develop Typhoid Disease.

PLoS Negl Trop Dis 2015 Jun 11;9(6):e0003837. Epub 2015 Jun 11.

Center for Vaccine Development, University of Maryland School of Medicine, Baltimore, Maryland, United States of America; Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland, United States of America; Department of Pediatrics, University of Maryland School of Medicine, Baltimore, Maryland, United States of America.

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http://dx.doi.org/10.1371/journal.pntd.0003837DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4465829PMC
June 2015