Gordon Dougan

Gordon Dougan

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Gordon Dougan

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Screening of healthcare workers for SARS-CoV-2 highlights the role of asymptomatic carriage in COVID-19 transmission.

Authors:
Lucy Rivett Sushmita Sridhar Dominic Sparkes Matthew Routledge Nick K Jones Sally Forrest Jamie Young Joana Pereira-Dias William L Hamilton Mark Ferris M Estee Torok Luke Meredith Ravi Gupta Paul A Lyons Mark Toshner Ben Warne Josefin Bartholdson Scott Claire Cormie Harmeet Gill Iain Kean Mailis Maes Nicola Reynolds Michelle Wantoch Sarah Caddy Laura Caller Theresa Feltwell Grant Hall Myra Hosmillo Charlotte Houldcroft Aminu Jahun Fahad Khokhar Anna Yakovleva Helen Butcher Daniela Caputo Debra Clapham-Riley Helen Dolling Anita Furlong Barbara Graves Emma Le Gresley Nathalie Kingston Sofia Papadia Hannah Stark Kathleen E Stirrups Jennifer Webster Joanna Calder Julie Harris Sarah Hewitt Jane Kennet Anne Meadows Rebecca Rastall Criona O Brien Jo Price Cherry Publico Jane Rowlands Valentina Ruffolo Hugo Tordesillas Karen Brookes Laura Canna Isabel Cruz Katie Dempsey Anne Elmer Naidine Escoffery Heather Jones Carla Ribeiro Caroline Saunders Angela Wright Rutendo Nyagumbo Anne Roberts Ashlea Bucke Simone Hargreaves Danielle Johnson Aileen Narcorda Debbie Read Christian Sparke Lucy Warboys Kirsty Lagadu Lenette Mactavous Tim Gould Tim Raine Claire Mather Nicola Ramenatte Anne-Laure Vallier Mary Kasanicki Penelope-Jane Eames Chris McNicholas Lisa Thake Neil Bartholomew Nick Brown Surendra Parmar Hongyi Zhang Ailsa Bowring Geraldine Martell Natalie Quinnell Jo Wright Helen Murphy Benjamin J Dunmore Ekaterina Legchenko Stefan Gräf Christopher Huang Josh Hodgson Kelvin Hunter Jennifer Martin Federica Mescia Ciara O'Donnell Linda Pointon Joy Shih Rachel Sutcliffe Tobias Tilly Zhen Tong Carmen Treacy Jennifer Wood Laura Bergamaschi Ariana Betancourt Georgie Bowyer Aloka De Sa Maddie Epping Andrew Hinch Oisin Huhn Isobel Jarvis Daniel Lewis Joe Marsden Simon McCallum Francescsa Nice Martin D Curran Stewart Fuller Afzal Chaudhry Ashley Shaw Richard J Samworth John R Bradley Gordon Dougan Kenneth Gc Smith Paul J Lehner Nicholas J Matheson Giles Wright Ian G Goodfellow Stephen Baker Michael P Weekes

Elife 2020 05 11;9. Epub 2020 May 11.

Department of Infectious Diseases, Cambridge University NHS Hospitals Foundation Trust, Cambridge, United Kingdom.

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http://dx.doi.org/10.7554/eLife.58728DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7314537PMC
May 2020

Derivation of Intestinal Organoids from Human Induced Pluripotent Stem Cells for Use as an Infection System.

Methods Mol Biol 2019 ;1576:157-169

Wellcome Trust Sanger Institute, Hinxton, Cambridge, UK.

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http://dx.doi.org/10.1007/7651_2016_7DOI Listing
March 2020

Molecular epidemiology and intercontinental spread of cholera.

Vaccine 2020 Feb 22;38 Suppl 1:A46-A51. Epub 2019 Jul 22.

Department of Medicine, University of Cambridge, Cambridge CB2 0QQ, United Kingdom; Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1S, United Kingdom.

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http://dx.doi.org/10.1016/j.vaccine.2019.07.038DOI Listing
February 2020

Persistent circulation of a fluoroquinolone-resistant Salmonella enterica Typhi clone in the Indian subcontinent.

J Antimicrob Chemother 2020 Feb;75(2):337-341

Oxford Vaccine Group, Department of Paediatrics, University of Oxford, and the NIHR Oxford Biomedical Research Centre, Oxford, OX3 7LE, UK.

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http://dx.doi.org/10.1093/jac/dkz435DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7223262PMC
February 2020

Population structure and antimicrobial resistance patterns of Salmonella Typhi isolates in urban Dhaka, Bangladesh from 2004 to 2016.

PLoS Negl Trop Dis 2020 02 27;14(2):e0008036. Epub 2020 Feb 27.

Infectious Diseases Division, International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b), Dhaka, Bangladesh.

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http://dx.doi.org/10.1371/journal.pntd.0008036DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7064254PMC
February 2020

FAMIN Is a Multifunctional Purine Enzyme Enabling the Purine Nucleotide Cycle.

Cell 2020 01;180(2):278-295.e23

Cambridge Institute of Therapeutic Immunology and Infectious Disease, Jeffrey Cheah Biomedical Centre, University of Cambridge, Cambridge CB2 0AW, UK; Division of Gastroenterology and Hepatology, Department of Medicine, University of Cambridge, Addenbrooke's Hospital, Cambridge CB2 0QQ, UK. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2019.12.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6978800PMC
January 2020

Emergence of NDM-producing Klebsiella pneumoniae and Escherichia coli in Spain: phylogeny, resistome, virulence and plasmids encoding blaNDM-like genes as determined by WGS.

J Antimicrob Chemother 2019 12;74(12):3489-3496

Laboratorio de Referencia e Investigación en Resistencia a Antibióticos e Infecciones Relacionadas con la Asistencia Sanitaria, Centro Nacional de Microbiología, Instituto de Salud Carlos III, Majadahonda, Madrid, Spain.

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http://dx.doi.org/10.1093/jac/dkz366DOI Listing
December 2019

The flagellotropic bacteriophage YSD1 targets Salmonella Typhi with a Chi-like protein tail fibre.

Mol Microbiol 2019 12 9;112(6):1831-1846. Epub 2019 Oct 9.

Infection and Immunity Program, Department of Microbiology, Biomedicine Discovery Institute, Monash University, Clayton, 3800, Australia.

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http://dx.doi.org/10.1111/mmi.14396DOI Listing
December 2019

A Biohistorical Perspective of Typhoid and Antimicrobial Resistance.

Clin Infect Dis 2019 10;69(Suppl 5):S388-S394

Department of Medicine, University of Cambridge, Addenbrooke's Hospital, United Kingdom.

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http://dx.doi.org/10.1093/cid/ciz556DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6792120PMC
October 2019

Detection of Epidemic Scarlet Fever Group A Streptococcus in Australia.

Clin Infect Dis 2019 09;69(7):1232-1234

Department of Microbiology and Immunology, University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Victoria, Australia.

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http://dx.doi.org/10.1093/cid/ciz099DOI Listing
September 2019

Genome-Wide Epigenetic and Transcriptomic Characterization of Human-Induced Pluripotent Stem Cell-Derived Intestinal Epithelial Organoids.

Cell Mol Gastroenterol Hepatol 2019 23;7(2):285-288. Epub 2018 Oct 23.

Department of Pediatrics, University of Cambridge, Cambridge, United Kingdom; Department of Pediatric Gastroenterology, Hepatology and Nutrition, Addenbrooke's Hospital, Cambridge, United Kingdom; Wellcome Trust-Medical Research Council Stem Cell Institute, University of Cambridge, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/j.jcmgh.2018.10.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354438PMC
May 2019

Using Human Induced Pluripotent Stem Cell-derived Intestinal Organoids to Study and Modify Epithelial Cell Protection Against Salmonella and Other Pathogens.

J Vis Exp 2019 05 12(147). Epub 2019 May 12.

Wellcome Trust Sanger Institute; Department of Medicine, University of Cambridge.

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http://dx.doi.org/10.3791/59478DOI Listing
May 2019

Antibiotic Resistance and Typhoid.

Clin Infect Dis 2019 03;68(Suppl 2):S165-S170

Department of Medicine, University of Cambridge, Hinxton, Cambridge, United Kingdom.

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http://dx.doi.org/10.1093/cid/ciy1111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6405283PMC
March 2019

Using a Systems Biology Approach To Study Host-Pathogen Interactions.

Microbiol Spectr 2019 03;7(2)

Department of Medicine, University of Cambridge, Addenbrooke's Hospital, Cambridge CB2 0QQ, United Kingdom.

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http://dx.doi.org/10.1128/microbiolspec.BAI-0021-2019DOI Listing
March 2019

Meeting the discovery challenge of drug-resistant infections: progress and focusing resources.

Drug Discov Today 2019 02 23;24(2):452-461. Epub 2018 Nov 23.

Medicine Discovery Catapult, Mereside, Alderly Park, Alderly Edge, Cheshire, UK.

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https://linkinghub.elsevier.com/retrieve/pii/S13596446183023
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http://dx.doi.org/10.1016/j.drudis.2018.11.015DOI Listing
February 2019

Resistance mechanisms and population structure of highly drug resistant Klebsiella in Pakistan during the introduction of the carbapenemase NDM-1.

Sci Rep 2019 02 20;9(1):2392. Epub 2019 Feb 20.

Department of Microbiology and Immunology, The University of Melbourne, at Peter Doherty Institute for Infection and Immunity, Melbourne, Australia.

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http://dx.doi.org/10.1038/s41598-019-38943-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6382945PMC
February 2019

Emergence of dominant multidrug-resistant bacterial clades: Lessons from history and whole-genome sequencing.

Proc Natl Acad Sci U S A 2018 12;115(51):12872-12877

Infection Genomics Programme, Wellcome Trust Sanger Institute, CB10 1SA Cambridge, United Kingdom;

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http://dx.doi.org/10.1073/pnas.1717162115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6304985PMC
December 2018

The phylogeography and incidence of multi-drug resistant typhoid fever in sub-Saharan Africa.

Nat Commun 2018 11 30;9(1):5094. Epub 2018 Nov 30.

The Hospital for Tropical Diseases, Wellcome Trust Major Overseas Programme, Oxford University Clinical Research Unit, 764 Vo Van Kiet, Quant 5, Ho Chi Minh City, Vietnam.

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http://www.nature.com/articles/s41467-018-07370-z
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http://dx.doi.org/10.1038/s41467-018-07370-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6269545PMC
November 2018

Identification of novel adenovirus genotype 90 in children from Bangladesh.

Microb Genom 2018 10 24;4(10). Epub 2018 Sep 24.

1​Department of Medicine, University of Cambridge, Cambridge, UK.

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http://dx.doi.org/10.1099/mgen.0.000221DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6249435PMC
October 2018

An investigation into the Omp85 protein BamK in hypervirulent Klebsiella pneumoniae, and its role in outer membrane biogenesis.

Mol Microbiol 2018 09 19;109(5):584-599. Epub 2018 Sep 19.

Infection & Immunity Program, Biomedicine Discovery Institute and Department of Microbiology, Monash University, Clayton, 3800, Australia.

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http://dx.doi.org/10.1111/mmi.13990DOI Listing
September 2018

FusC, a member of the M16 protease family acquired by bacteria for iron piracy against plants.

PLoS Biol 2018 08 2;16(8):e2006026. Epub 2018 Aug 2.

Infection and Immunity Program, Biomedicine Discovery Institute and Department of Microbiology, Monash University, Clayton, Australia.

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http://dx.doi.org/10.1371/journal.pbio.2006026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6071955PMC
August 2018

Comparison of Salmonella enterica Serovars Typhi and Typhimurium Reveals Typhoidal Serovar-Specific Responses to Bile.

Infect Immun 2018 03 20;86(3). Epub 2018 Feb 20.

MRC Centre for Molecular Bacteriology and Infection, Department of Life Sciences, Imperial College London, London, United Kingdom

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http://dx.doi.org/10.1128/IAI.00490-17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5820949PMC
March 2018

PlasmidTron: assembling the cause of phenotypes and genotypes from NGS data.

Microb Genom 2018 03 12;4(3). Epub 2018 Mar 12.

1​Infection Genomics, Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK.

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http://dx.doi.org/10.1099/mgen.0.000164DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5885016PMC
March 2018

Outer membrane vesicles from Neisseria gonorrhoeae target PorB to mitochondria and induce apoptosis.

PLoS Pathog 2018 03 30;14(3):e1006945. Epub 2018 Mar 30.

Biomedicine Discovery Institute and Department of Biochemistry & Molecular Biology, Monash University, Clayton, Victoria, Australia.

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http://dx.doi.org/10.1371/journal.ppat.1006945DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5877877PMC
March 2018

Constraints on lateral gene transfer in promoting fimbrial usher protein diversity and function.

Open Biol 2017 11;7(11)

Infection Genomics Program, Wellcome Trust Sanger Institute, Hinxton CB10 1SA, UK

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http://dx.doi.org/10.1098/rsob.170144DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5717340PMC
November 2017

Preterm Infant-Associated Clostridium tertium, Clostridium cadaveris, and Clostridium paraputrificum Strains: Genomic and Evolutionary Insights.

Genome Biol Evol 2017 10;9(10):2707-2714

The Gut Health and Food Safety Programme, Quadram Institute Bioscience, Norwich Research Park, Norwich, United Kingdom.

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http://dx.doi.org/10.1093/gbe/evx210DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5647805PMC
October 2017

Complete Genome Sequence of Serotype III Sequence Type 17 Strain 874391.

Genome Announc 2017 Oct 19;5(42). Epub 2017 Oct 19.

School of Medical Science, and Menzies Health Institute Queensland, Griffith University, Gold Coast, Australia

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http://dx.doi.org/10.1128/genomeA.01107-17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5646402PMC
October 2017

Induction of Cell Cycle and NK Cell Responses by Live-Attenuated Oral Vaccines against Typhoid Fever.

Front Immunol 2017 12;8:1276. Epub 2017 Oct 12.

Oxford Vaccine Group, Department of Paediatrics, University of Oxford, NIHR Oxford Biomedical Research Centre, Oxford, United Kingdom.

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http://dx.doi.org/10.3389/fimmu.2017.01276DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5643418PMC
October 2017

An evaluation of purified Salmonella Typhi protein antigens for the serological diagnosis of acute typhoid fever.

J Infect 2017 08 25;75(2):104-114. Epub 2017 May 25.

The Hospital for Tropical Diseases, Wellcome Trust Major Overseas Programme, Oxford University Clinical Research Unit, Ho Chi Minh City, Viet Nam; Centre for Tropical Medicine and Global Health, Oxford University, Oxford, United Kingdom; The Department of Medicine, University of Cambridge, Cambridge, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/j.jinf.2017.05.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5522525PMC
August 2017

Hyperactivation of HUSH complex function by Charcot-Marie-Tooth disease mutation in MORC2.

Nat Genet 2017 Jul 5;49(7):1035-1044. Epub 2017 Jun 5.

Department of Medicine, Cambridge Institute for Medical Research, Cambridge Biomedical Campus, Cambridge, CB2 0XY, UK.

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http://dx.doi.org/10.1038/ng.3878DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5493197PMC
July 2017

Typhoid in Africa and vaccine deployment.

Authors:
Gordon Dougan

Lancet Glob Health 2017 03;5(3):e236-e237

The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SA, UK; Department of Medicine, University of Cambridge, Addenbrooke's Hospital, Cambridge, UK. Electronic address:

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http://dx.doi.org/10.1016/S2214-109X(17)30045-1DOI Listing
March 2017

The Type III Secretion System Effector SptP of Salmonella enterica Serovar Typhi.

J Bacteriol 2017 02 30;199(4). Epub 2017 Jan 30.

MRC Centre for Molecular Bacteriology and Infection, Department of Life Sciences, Imperial College London, London, United Kingdom

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http://dx.doi.org/10.1128/JB.00647-16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5287405PMC
February 2017

Mitochondrial Protein Lipoylation and the 2-Oxoglutarate Dehydrogenase Complex Controls HIF1α Stability in Aerobic Conditions.

Cell Metab 2016 11 27;24(5):740-752. Epub 2016 Oct 27.

Department of Medicine, Cambridge Institute for Medical Research, University of Cambridge, Cambridge, CB2 0XY, UK. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2016.09.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5106373PMC
November 2016

Retrospective Analysis of Serotype Switching of Vibrio cholerae O1 in a Cholera Endemic Region Shows It Is a Non-random Process.

PLoS Negl Trop Dis 2016 Oct 5;10(10):e0005044. Epub 2016 Oct 5.

Department of Microbiology and Immunology, Institute of Biomedicine, University of Gothenburg, Gothenburg, Sweden.

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http://dx.doi.org/10.1371/journal.pntd.0005044DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5051702PMC
October 2016

ATF7IP-Mediated Stabilization of the Histone Methyltransferase SETDB1 Is Essential for Heterochromatin Formation by the HUSH Complex.

Cell Rep 2016 10;17(3):653-659

Department of Medicine, Cambridge Institute for Medical Research, Cambridge Biomedical Campus, Cambridge CB2 0XY, UK. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2016.09.050DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5081395PMC
October 2016

Five decades of genome evolution in the globally distributed, extensively antibiotic-resistant global clone 1.

Microb Genom 2016 02 23;2(2):e000052. Epub 2016 Feb 23.

3​ School of Molecular Bioscience, The University of Sydney, Sydney, New South Wales, Australia.

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http://dx.doi.org/10.1099/mgen.0.000052DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5320584PMC
February 2016